chloroquine and Coma
chloroquine has been researched along with Coma in 17 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
Coma: A profound state of unconsciousness associated with depressed cerebral activity from which the individual cannot be aroused. Coma generally occurs when there is dysfunction or injury involving both cerebral hemispheres or the brain stem RETICULAR FORMATION.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "A 19-year-old patient in deep anoxic coma after cardiopulmonary arrest due to suicidal acute overdosage of chloroquine was resuscitated at the intensive care unit." | 7.68 | Electroencephalographic findings in coma caused by fatal chloroquine poisoning. ( Martinović, Z; Sasić, M, 1990) |
| "A death from chloroquinoresistant falciparum malaria contracted by a traveller under chloroquine chemoprophylaxis during a stay in the Cameroon provides the authors with an opportunity to analyze the extension of chloroquinoresistance in Africa." | 7.67 | [A fatal case of chloroquine-resistant neuromalaria in a traveller to Cameroon]. ( Beylot, J; Combe, A; Le Bras, J; Le Bras, M; Raccurt, CP; Ripert, C, 1986) |
| "Chloroquine has been reported to antagonise the anti-parasitic action of quinine against Plasmodium falciparum in vitro." | 6.67 | Efficacy of quinine for falciparum malaria according to previous chloroquine exposure. ( Mansor, S; Molyneux, ME; Taylor, TE; Thomas, CG; Wirima, JJ, 1991) |
| "At least four doses of quinine followed by a single dose of mefloquine or by a single dose of sulfadoxine-pyrimethamine are two highly effective regimens for chloroquine-resistant falciparum malaria." | 4.75 | The treatment of malaria. ( Hall, AP, 1976) |
| "A death from chloroquinoresistant falciparum malaria contracted by a traveller under chloroquine chemoprophylaxis during a stay in the Cameroon provides the authors with an opportunity to analyze the extension of chloroquinoresistance in Africa." | 3.67 | [A fatal case of chloroquine-resistant neuromalaria in a traveller to Cameroon]. ( Beylot, J; Combe, A; Le Bras, J; Le Bras, M; Raccurt, CP; Ripert, C, 1986) |
| "Children with deep coma (scoring 0-2) had significantly longer duration of coma before presentation (P = 0." | 2.68 | Predictors of severity of illness on presentation in children with cerebral malaria. ( Biemba, G; Gordeuk, VR; Khumalo, H; Mabeza, GF; Moyo, VM; Nyarugwe, P; Parry, D; Thuma, PE; Zulu, S, 1995) |
| "Chloroquine has been reported to antagonise the anti-parasitic action of quinine against Plasmodium falciparum in vitro." | 2.67 | Efficacy of quinine for falciparum malaria according to previous chloroquine exposure. ( Mansor, S; Molyneux, ME; Taylor, TE; Thomas, CG; Wirima, JJ, 1991) |
| "Refractory seizures not responding to benzodiazepine may require an antiepileptic drug." | 1.31 | Chloroquine poisoning: report of two cases. ( Reddy, VG; Sinna, S, 2000) |
| "The utility of the Glasgow coma scale and quantitative assessment of parasitaemia levels as diagnostic and prognostic indices in cerebral malaria were determined in this study." | 1.28 | Pediatric cerebral malaria in Accra, Ghana. ( Bia, FJ; Commey, JO; Osei, L; Wolf-Gould, C, 1992) |
| "falciparum malaria and unrousable coma)." | 1.28 | Clinical features and prognostic indicators in paediatric cerebral malaria: a study of 131 comatose Malawian children. ( Borgstein, A; Molyneux, ME; Taylor, TE; Wirima, JJ, 1989) |
| "In a man who had been in a coma for 24 hours with cerebral malaria dexamethasone had a dramatic, and probably life-saving, effect." | 1.25 | Use of dexamethasone in cerebral malaria. ( Dickinson, CJ; Woodruff, AW, 1968) |
Research
Studies (17)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (58.82) | 18.7374 |
| 1990's | 6 (35.29) | 18.2507 |
| 2000's | 1 (5.88) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Mabeza, GF | 1 |
| Moyo, VM | 1 |
| Thuma, PE | 1 |
| Biemba, G | 1 |
| Parry, D | 1 |
| Khumalo, H | 1 |
| Nyarugwe, P | 1 |
| Zulu, S | 1 |
| Gordeuk, VR | 1 |
| Reddy, VG | 1 |
| Sinna, S | 1 |
| Hall, AP | 1 |
| Tempe, JD | 1 |
| Jaeger, A | 1 |
| Beissel, J | 1 |
| Burg, F | 1 |
| Mantz, JM | 1 |
| Molyneux, ME | 2 |
| Taylor, TE | 2 |
| Thomas, CG | 1 |
| Mansor, S | 1 |
| Wirima, JJ | 2 |
| Wolf-Gould, C | 1 |
| Osei, L | 1 |
| Commey, JO | 1 |
| Bia, FJ | 1 |
| Brewster, DR | 1 |
| Kwiatkowski, D | 1 |
| White, NJ | 1 |
| Bondi, FS | 1 |
| Martinović, Z | 1 |
| Sasić, M | 1 |
| Borgstein, A | 1 |
| Havens, PL | 1 |
| Splaingard, ML | 1 |
| Bousounis, D | 1 |
| Hoffman, GM | 1 |
| Raccurt, CP | 1 |
| Le Bras, M | 1 |
| Le Bras, J | 1 |
| Beylot, J | 1 |
| Combe, A | 1 |
| Ripert, C | 1 |
| Mitchell, AD | 1 |
| Eales, L | 1 |
| Pokrovskiĭ, VI | 1 |
| Kashin, AM | 1 |
| Woodruff, AW | 1 |
| Dickinson, CJ | 1 |
| Carayon, A | 1 |
| Reville, JJ | 1 |
| Blin, F | 1 |
| Vincent, M | 1 |
Clinical Trials (1)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| An MRI Ancillary Study of a Malaria Fever Randomized Controlled Trial (RCT)[NCT05746819] | 256 participants (Anticipated) | Observational | 2021-01-02 | Enrolling by invitation | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Reviews
2 reviews available for chloroquine and Coma
| Article | Year |
|---|---|
The treatment of malaria.
Topics: Anemia; Antimalarials; Blackwater Fever; Child; Child, Preschool; Chloroquine; Coma; Drug Combinatio | 1976 |
Neurological sequelae of cerebral malaria in children.
Topics: Adolescent; Animals; Antimalarials; Brain Diseases; Child; Chloroquine; Coma; Follow-Up Studies; Gam | 1990 |
Trials
2 trials available for chloroquine and Coma
| Article | Year |
|---|---|
Predictors of severity of illness on presentation in children with cerebral malaria.
Topics: Age of Onset; Anemia; Child, Preschool; Chloroquine; Coma; Double-Blind Method; Drug Resistance; Fem | 1995 |
Efficacy of quinine for falciparum malaria according to previous chloroquine exposure.
Topics: Animals; Child; Child, Preschool; Chloroquine; Coma; Drug Evaluation; Drug Resistance; Female; Human | 1991 |
Other Studies
13 other studies available for chloroquine and Coma
| Article | Year |
|---|---|
Chloroquine poisoning: report of two cases.
Topics: Adult; Anticonvulsants; Antidotes; Antimalarials; Charcoal; Chloroquine; Coma; Diazepam; Drug Overdo | 2000 |
[Acute intoxications due to cardiotropic drugs : ajmaline, chloroquine and digitalin].
Topics: Acute Disease; Adolescent; Adult; Ajmaline; Chloroquine; Coma; Digitalis Glycosides; Female; Humans; | 1976 |
Pediatric cerebral malaria in Accra, Ghana.
Topics: Child; Child, Preschool; Chloroquine; Coma; Consciousness; Female; Ghana; Glasgow Coma Scale; Humans | 1992 |
Childhood cerebral malaria in Ibadan.
Topics: Acute Disease; Child; Child, Preschool; Chloroquine; Coma; Female; Humans; Infant; Malaria; Male; Ni | 1991 |
Electroencephalographic findings in coma caused by fatal chloroquine poisoning.
Topics: Adult; Chloroquine; Coma; Electroencephalography; Female; Humans; Poisoning | 1990 |
Clinical features and prognostic indicators in paediatric cerebral malaria: a study of 131 comatose Malawian children.
Topics: Anemia; Animals; Blinking; Brain Diseases; Child; Child, Preschool; Chloroquine; Coma; Female; Human | 1989 |
Survival after chloroquine ingestion in a child.
Topics: Brain Edema; Chloroquine; Coma; Electroencephalography; Evoked Potentials; Humans; Infant; Male; Ner | 1988 |
[A fatal case of chloroquine-resistant neuromalaria in a traveller to Cameroon].
Topics: Africa; Amodiaquine; Cameroon; Cerebral Hemorrhage; Chloroquine; Coma; Drug Resistance; Humans; Mala | 1986 |
Recent experiences with severe and cerebral malaria.
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Brain Diseases; Child; Child, Preschool; Chloroquine; Co | 1974 |
Acute falciparum malaria. Complications and treatment.
Topics: Acute Kidney Injury; Brain Diseases; Chloroquine; Coma; Disseminated Intravascular Coagulation; Hepa | 1974 |
[Delagil treatment of malarial coma].
Topics: Adult; Chloroquine; Coma; Female; Humans; Malaria | 1971 |
Use of dexamethasone in cerebral malaria.
Topics: Adult; Brain Edema; Chloroquine; Coma; Dexamethasone; Humans; Malaria; Male | 1968 |
[3 cases of coma due to ingestion of nivaquine (chloroquine). Favorable prognosis after surgical irrigation of the small intestine].
Topics: Adult; Chloroquine; Coma; Female; Humans; Intestine, Small; Male; Suicide; Therapeutic Irrigation | 1968 |