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chloroquine and Coma

chloroquine has been researched along with Coma in 17 studies

Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.

Coma: A profound state of unconsciousness associated with depressed cerebral activity from which the individual cannot be aroused. Coma generally occurs when there is dysfunction or injury involving both cerebral hemispheres or the brain stem RETICULAR FORMATION.

Research Excerpts

ExcerptRelevanceReference
"A 19-year-old patient in deep anoxic coma after cardiopulmonary arrest due to suicidal acute overdosage of chloroquine was resuscitated at the intensive care unit."7.68Electroencephalographic findings in coma caused by fatal chloroquine poisoning. ( Martinović, Z; Sasić, M, 1990)
"A death from chloroquinoresistant falciparum malaria contracted by a traveller under chloroquine chemoprophylaxis during a stay in the Cameroon provides the authors with an opportunity to analyze the extension of chloroquinoresistance in Africa."7.67[A fatal case of chloroquine-resistant neuromalaria in a traveller to Cameroon]. ( Beylot, J; Combe, A; Le Bras, J; Le Bras, M; Raccurt, CP; Ripert, C, 1986)
"Chloroquine has been reported to antagonise the anti-parasitic action of quinine against Plasmodium falciparum in vitro."6.67Efficacy of quinine for falciparum malaria according to previous chloroquine exposure. ( Mansor, S; Molyneux, ME; Taylor, TE; Thomas, CG; Wirima, JJ, 1991)
"At least four doses of quinine followed by a single dose of mefloquine or by a single dose of sulfadoxine-pyrimethamine are two highly effective regimens for chloroquine-resistant falciparum malaria."4.75The treatment of malaria. ( Hall, AP, 1976)
"A death from chloroquinoresistant falciparum malaria contracted by a traveller under chloroquine chemoprophylaxis during a stay in the Cameroon provides the authors with an opportunity to analyze the extension of chloroquinoresistance in Africa."3.67[A fatal case of chloroquine-resistant neuromalaria in a traveller to Cameroon]. ( Beylot, J; Combe, A; Le Bras, J; Le Bras, M; Raccurt, CP; Ripert, C, 1986)
"Children with deep coma (scoring 0-2) had significantly longer duration of coma before presentation (P = 0."2.68Predictors of severity of illness on presentation in children with cerebral malaria. ( Biemba, G; Gordeuk, VR; Khumalo, H; Mabeza, GF; Moyo, VM; Nyarugwe, P; Parry, D; Thuma, PE; Zulu, S, 1995)
"Chloroquine has been reported to antagonise the anti-parasitic action of quinine against Plasmodium falciparum in vitro."2.67Efficacy of quinine for falciparum malaria according to previous chloroquine exposure. ( Mansor, S; Molyneux, ME; Taylor, TE; Thomas, CG; Wirima, JJ, 1991)
"Refractory seizures not responding to benzodiazepine may require an antiepileptic drug."1.31Chloroquine poisoning: report of two cases. ( Reddy, VG; Sinna, S, 2000)
"The utility of the Glasgow coma scale and quantitative assessment of parasitaemia levels as diagnostic and prognostic indices in cerebral malaria were determined in this study."1.28Pediatric cerebral malaria in Accra, Ghana. ( Bia, FJ; Commey, JO; Osei, L; Wolf-Gould, C, 1992)
"falciparum malaria and unrousable coma)."1.28Clinical features and prognostic indicators in paediatric cerebral malaria: a study of 131 comatose Malawian children. ( Borgstein, A; Molyneux, ME; Taylor, TE; Wirima, JJ, 1989)
"In a man who had been in a coma for 24 hours with cerebral malaria dexamethasone had a dramatic, and probably life-saving, effect."1.25Use of dexamethasone in cerebral malaria. ( Dickinson, CJ; Woodruff, AW, 1968)

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-199010 (58.82)18.7374
1990's6 (35.29)18.2507
2000's1 (5.88)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Mabeza, GF1
Moyo, VM1
Thuma, PE1
Biemba, G1
Parry, D1
Khumalo, H1
Nyarugwe, P1
Zulu, S1
Gordeuk, VR1
Reddy, VG1
Sinna, S1
Hall, AP1
Tempe, JD1
Jaeger, A1
Beissel, J1
Burg, F1
Mantz, JM1
Molyneux, ME2
Taylor, TE2
Thomas, CG1
Mansor, S1
Wirima, JJ2
Wolf-Gould, C1
Osei, L1
Commey, JO1
Bia, FJ1
Brewster, DR1
Kwiatkowski, D1
White, NJ1
Bondi, FS1
Martinović, Z1
Sasić, M1
Borgstein, A1
Havens, PL1
Splaingard, ML1
Bousounis, D1
Hoffman, GM1
Raccurt, CP1
Le Bras, M1
Le Bras, J1
Beylot, J1
Combe, A1
Ripert, C1
Mitchell, AD1
Eales, L1
Pokrovskiĭ, VI1
Kashin, AM1
Woodruff, AW1
Dickinson, CJ1
Carayon, A1
Reville, JJ1
Blin, F1
Vincent, M1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
An MRI Ancillary Study of a Malaria Fever Randomized Controlled Trial (RCT)[NCT05746819]256 participants (Anticipated)Observational2021-01-02Enrolling by invitation
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for chloroquine and Coma

ArticleYear
The treatment of malaria.
    British medical journal, 1976, Feb-07, Volume: 1, Issue:6005

    Topics: Anemia; Antimalarials; Blackwater Fever; Child; Child, Preschool; Chloroquine; Coma; Drug Combinatio

1976
Neurological sequelae of cerebral malaria in children.
    Lancet (London, England), 1990, Oct-27, Volume: 336, Issue:8722

    Topics: Adolescent; Animals; Antimalarials; Brain Diseases; Child; Chloroquine; Coma; Follow-Up Studies; Gam

1990

Trials

2 trials available for chloroquine and Coma

ArticleYear
Predictors of severity of illness on presentation in children with cerebral malaria.
    Annals of tropical medicine and parasitology, 1995, Volume: 89, Issue:3

    Topics: Age of Onset; Anemia; Child, Preschool; Chloroquine; Coma; Double-Blind Method; Drug Resistance; Fem

1995
Efficacy of quinine for falciparum malaria according to previous chloroquine exposure.
    Lancet (London, England), 1991, Jun-08, Volume: 337, Issue:8754

    Topics: Animals; Child; Child, Preschool; Chloroquine; Coma; Drug Evaluation; Drug Resistance; Female; Human

1991

Other Studies

13 other studies available for chloroquine and Coma

ArticleYear
Chloroquine poisoning: report of two cases.
    Acta anaesthesiologica Scandinavica, 2000, Volume: 44, Issue:8

    Topics: Adult; Anticonvulsants; Antidotes; Antimalarials; Charcoal; Chloroquine; Coma; Diazepam; Drug Overdo

2000
[Acute intoxications due to cardiotropic drugs : ajmaline, chloroquine and digitalin].
    Minerva medica, 1976, Dec-15, Volume: 67, Issue:61

    Topics: Acute Disease; Adolescent; Adult; Ajmaline; Chloroquine; Coma; Digitalis Glycosides; Female; Humans;

1976
Pediatric cerebral malaria in Accra, Ghana.
    Journal of tropical pediatrics, 1992, Volume: 38, Issue:6

    Topics: Child; Child, Preschool; Chloroquine; Coma; Consciousness; Female; Ghana; Glasgow Coma Scale; Humans

1992
Childhood cerebral malaria in Ibadan.
    Journal of tropical pediatrics, 1991, Volume: 37, Issue:2

    Topics: Acute Disease; Child; Child, Preschool; Chloroquine; Coma; Female; Humans; Infant; Malaria; Male; Ni

1991
Electroencephalographic findings in coma caused by fatal chloroquine poisoning.
    Neurologija, 1990, Volume: 39, Issue:4

    Topics: Adult; Chloroquine; Coma; Electroencephalography; Female; Humans; Poisoning

1990
Clinical features and prognostic indicators in paediatric cerebral malaria: a study of 131 comatose Malawian children.
    The Quarterly journal of medicine, 1989, Volume: 71, Issue:265

    Topics: Anemia; Animals; Blinking; Brain Diseases; Child; Child, Preschool; Chloroquine; Coma; Female; Human

1989
Survival after chloroquine ingestion in a child.
    Journal of toxicology. Clinical toxicology, 1988, Volume: 26, Issue:5-6

    Topics: Brain Edema; Chloroquine; Coma; Electroencephalography; Evoked Potentials; Humans; Infant; Male; Ner

1988
[A fatal case of chloroquine-resistant neuromalaria in a traveller to Cameroon].
    Bulletin de la Societe de pathologie exotique et de ses filiales, 1986, Volume: 79, Issue:1

    Topics: Africa; Amodiaquine; Cameroon; Cerebral Hemorrhage; Chloroquine; Coma; Drug Resistance; Humans; Mala

1986
Recent experiences with severe and cerebral malaria.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1974, Jun-09, Volume: 48, Issue:31

    Topics: Adolescent; Adrenal Cortex Hormones; Adult; Brain Diseases; Child; Child, Preschool; Chloroquine; Co

1974
Acute falciparum malaria. Complications and treatment.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1974, Jul-06, Volume: 48, Issue:32

    Topics: Acute Kidney Injury; Brain Diseases; Chloroquine; Coma; Disseminated Intravascular Coagulation; Hepa

1974
[Delagil treatment of malarial coma].
    Sovetskaia meditsina, 1971, Volume: 34, Issue:10

    Topics: Adult; Chloroquine; Coma; Female; Humans; Malaria

1971
Use of dexamethasone in cerebral malaria.
    British medical journal, 1968, Jul-06, Volume: 3, Issue:5609

    Topics: Adult; Brain Edema; Chloroquine; Coma; Dexamethasone; Humans; Malaria; Male

1968
[3 cases of coma due to ingestion of nivaquine (chloroquine). Favorable prognosis after surgical irrigation of the small intestine].
    Bulletin de la Societe medicale d'Afrique noire de langue francaise, 1968, Volume: 13, Issue:2

    Topics: Adult; Chloroquine; Coma; Female; Humans; Intestine, Small; Male; Suicide; Therapeutic Irrigation

1968