Page last updated: 2024-10-16

carnitine and Sepsis

carnitine has been researched along with Sepsis in 23 studies

Sepsis: Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.

Research Excerpts

ExcerptRelevanceReference
"Because of the anti-inflammatory and antioxidant properties of L-carnitine, it is possible that using a high dose of 3000 mg daily of this nutritional supplement may reduce inflammation and oxidative stress and improve subsequent mortality of critically ill patients with sepsis."9.51The effects of L-carnitine supplementation on inflammatory factors, oxidative stress, and clinical outcomes in patients with sepsis admitted to the intensive care unit (ICU): study protocol for a double blind, randomized, placebo-controlled clinical trial ( Alikiaii, B; Askari, G; Bagherniya, M; Ferns, GA; Keshani, M; Yahyapoor, F, 2022)
"The precise role of carnitine as the key regulator of lipid metabolism in sepsis is unclear."8.89Carnitine and sepsis: a review of an old clinical dilemma. ( Elyasi, S; Farsaie, S; Hatamkhani, S; Karimzadeh, I; Khalili, H, 2013)
"To clarify the early predictive value of presepsin and acylcarnitines as biomarkers of severity of acute cholangitis and the need for biliary drainage."8.31Predictive value of presepsin and acylcarnitines for severity and biliary drainage in acute cholangitis. ( Li, CS; Lu, ZQ; Wang, GX; Xiao, HL; Xie, MR; Zhang, HY, 2023)
"We confirm that plasma acetylcarnitine can reflect the severity of organ dysfunction, inflammation, and infection in sepsis and can serve as a prognostic biomarker for mortality prediction."7.91Increased Plasma Acetylcarnitine in Sepsis Is Associated With Multiple Organ Dysfunction and Mortality: A Multicenter Cohort Study. ( Chang, HT; Chen, GY; Chen, YF; Chen, YJ; Chuang, TY; Chung, KP; Hsu, CL; Huang, MT; Huang, YT; Kuo, CH; Liu, WL; Yu, CJ, 2019)
"This study aimed to investigate the effects of L-carnitine, with its known antioxidant properties and positive effects on wound healing, on the healing of colon anastomosis in a cecal ligation and puncture sepsis model in rats."7.81The Effect of Systemic Carnitine Administration on Colon Anastomosis Healing in an Experimental Sepsis Model. ( Çikman, Ö; Ercan, U; Karaayvaz, M; Kilinç, N; Kiraz, A; Kiraz, HA; Otkun, MT; Özkan, ÖF; Türkön, H, 2015)
"Increased plasma concentrations of the endogenous nitric oxide synthase inhibitor, asymmetric dimethylarginine, decreased arginine bioavailability, and mitochondrial dysfunction have been reported in adult sepsis."7.78Evaluation of asymmetric dimethylarginine, arginine, and carnitine metabolism in pediatric sepsis. ( Chace, DH; De Jesus, VR; Haymond, S; Ralay Ranaivo, H; Wainwright, MS; Wang, D; Weiss, SL, 2012)
"L-carnitine is a potent antioxidant."6.82L-carnitine: Searching for New Therapeutic Strategy for Sepsis Management. ( Avan, R; Habtemariam, S; Hashemi, J; Monajati, M; Negintaji, S; Saghafi, F; Sahebnasagh, A, 2022)
"Sepsis is defined as the dysregulated host response to an infection resulting in life-threatening organ dysfunction."6.58A review of micronutrients in sepsis: the role of thiamine, l-carnitine, vitamin C, selenium and vitamin D. ( Belsky, JB; Jacob, V; Lee, PJ; Sather, JE; Wira, CR, 2018)
"Because of the anti-inflammatory and antioxidant properties of L-carnitine, it is possible that using a high dose of 3000 mg daily of this nutritional supplement may reduce inflammation and oxidative stress and improve subsequent mortality of critically ill patients with sepsis."5.51The effects of L-carnitine supplementation on inflammatory factors, oxidative stress, and clinical outcomes in patients with sepsis admitted to the intensive care unit (ICU): study protocol for a double blind, randomized, placebo-controlled clinical trial ( Alikiaii, B; Askari, G; Bagherniya, M; Ferns, GA; Keshani, M; Yahyapoor, F, 2022)
"Recent clinical trial studies have reported that L-carnitine supplementation can reduce the mortality rate in patients with sepsis, but there are no definitive results in this context."5.12The Effect of L-Carnitine on Mortality Rate in Septic Patients: A Systematic Review and Meta-Analysis on Randomized Clinical Trials. ( Abdolahi, M; Abdollahi, H; Jafarieh, A; Sedighiyan, M, 2021)
"The aim of this study was to evaluate to what extent secondary carnitine deficiency may exist based on the prevalence of subnormal carnitine status in patients with critical illness and abnormal nutritional state."5.07Prevalence of carnitine depletion in critically ill patients with undernutrition. ( Arfvidsson, B; Hyltander, A; Lundholm, K; Sandström, R; Sjöberg, A; Wennberg, A; Wickström, I, 1992)
" This article reviews some of the pharmacologic roles that parenteral nutritional ingredients (selenium, lipid emulsion, insulin, and levocarnitine) can play in the setting of critical illness."4.90Nutrition as medical therapy. ( DiNapoli, M; Miller, MA; Ross, B; Yogaratnam, D, 2014)
"The precise role of carnitine as the key regulator of lipid metabolism in sepsis is unclear."4.89Carnitine and sepsis: a review of an old clinical dilemma. ( Elyasi, S; Farsaie, S; Hatamkhani, S; Karimzadeh, I; Khalili, H, 2013)
"To clarify the early predictive value of presepsin and acylcarnitines as biomarkers of severity of acute cholangitis and the need for biliary drainage."4.31Predictive value of presepsin and acylcarnitines for severity and biliary drainage in acute cholangitis. ( Li, CS; Lu, ZQ; Wang, GX; Xiao, HL; Xie, MR; Zhang, HY, 2023)
"We confirm that plasma acetylcarnitine can reflect the severity of organ dysfunction, inflammation, and infection in sepsis and can serve as a prognostic biomarker for mortality prediction."3.91Increased Plasma Acetylcarnitine in Sepsis Is Associated With Multiple Organ Dysfunction and Mortality: A Multicenter Cohort Study. ( Chang, HT; Chen, GY; Chen, YF; Chen, YJ; Chuang, TY; Chung, KP; Hsu, CL; Huang, MT; Huang, YT; Kuo, CH; Liu, WL; Yu, CJ, 2019)
"This study aimed to investigate the effects of L-carnitine, with its known antioxidant properties and positive effects on wound healing, on the healing of colon anastomosis in a cecal ligation and puncture sepsis model in rats."3.81The Effect of Systemic Carnitine Administration on Colon Anastomosis Healing in an Experimental Sepsis Model. ( Çikman, Ö; Ercan, U; Karaayvaz, M; Kilinç, N; Kiraz, A; Kiraz, HA; Otkun, MT; Özkan, ÖF; Türkön, H, 2015)
"Increased plasma concentrations of the endogenous nitric oxide synthase inhibitor, asymmetric dimethylarginine, decreased arginine bioavailability, and mitochondrial dysfunction have been reported in adult sepsis."3.78Evaluation of asymmetric dimethylarginine, arginine, and carnitine metabolism in pediatric sepsis. ( Chace, DH; De Jesus, VR; Haymond, S; Ralay Ranaivo, H; Wainwright, MS; Wang, D; Weiss, SL, 2012)
"Blood concentrations of branched chain amino acids (BCAA; leucine, isoleucine, and valine) and glutamine (Gln) decrease markedly in sepsis."3.69Effect of carnitine on decrease of branched chain amino acids and glutamine in serum of septic rats. ( Handa, H; Hayashi, N; Kashiwabara, N; Takeshita, Y; Yamakawa, M; Yoshihara, D, 1996)
"L-carnitine is a potent antioxidant."2.82L-carnitine: Searching for New Therapeutic Strategy for Sepsis Management. ( Avan, R; Habtemariam, S; Hashemi, J; Monajati, M; Negintaji, S; Saghafi, F; Sahebnasagh, A, 2022)
"Sepsis and septic shock are severe and difficult-to-treat conditions with high lethality."2.82The supplementation of L-carnitine in septic shock patients: Systematic review and meta-analysis. ( Guedes, GV; Minicucci, MF; Tanni, SE, 2022)
"Sepsis is defined as the dysregulated host response to an infection resulting in life-threatening organ dysfunction."2.58A review of micronutrients in sepsis: the role of thiamine, l-carnitine, vitamin C, selenium and vitamin D. ( Belsky, JB; Jacob, V; Lee, PJ; Sather, JE; Wira, CR, 2018)
"The metabolic response to trauma and sepsis involves an increased loss of body proteins."2.40Metabolic response to injury and sepsis: changes in protein metabolism. ( Biolo, G; Ciocchi, B; Guarnieri, G; Gullo, A; Iscra, F; Situlin, R; Toigo, G, 1997)
"Sepsis is the response of the host to an infection that produces lesions in its own organs and tissues."1.42Metabolite analysis in sepsis through conditional independence maps. ( Artigas, A; Brunelli, L; Ferrer, R; Goma, G; Navas, A; Pastorelli, R; Ribas Ripoll, V; Romay, E, 2015)
" In heart fibers a dosage of 100 microg LPS."1.31Different sensitivity of rabbit heart and skeletal muscle to endotoxin-induced impairment of mitochondrial function. ( Gellerich, FN; Neuhof, C; Opalka, JR; Trumbeckaite, S; Zierz, S, 2001)

Research

Studies (23)

TimeframeStudies, this research(%)All Research%
pre-19901 (4.35)18.7374
1990's5 (21.74)18.2507
2000's3 (13.04)29.6817
2010's8 (34.78)24.3611
2020's6 (26.09)2.80

Authors

AuthorsStudies
Sahebnasagh, A1
Avan, R1
Monajati, M1
Hashemi, J1
Habtemariam, S1
Negintaji, S1
Saghafi, F1
Keshani, M1
Alikiaii, B1
Askari, G1
Yahyapoor, F1
Ferns, GA1
Bagherniya, M1
Guedes, GV1
Minicucci, MF1
Tanni, SE1
Zhang, HY1
Xiao, HL1
Wang, GX1
Lu, ZQ1
Xie, MR1
Li, CS1
Abdollahi, H1
Abdolahi, M1
Sedighiyan, M1
Jafarieh, A1
Pagano, G1
Manfredi, C1
Pallardó, FV1
Lyakhovich, A1
Tiano, L1
Trifuoggi, M1
Belsky, JB1
Wira, CR1
Jacob, V1
Sather, JE1
Lee, PJ1
Chung, KP1
Chen, GY1
Chuang, TY1
Huang, YT1
Chang, HT1
Chen, YF1
Liu, WL1
Chen, YJ1
Hsu, CL1
Huang, MT1
Kuo, CH1
Yu, CJ1
Ventz, S1
Alexander, BM1
Trippa, L1
Hatamkhani, S1
Karimzadeh, I1
Elyasi, S1
Farsaie, S1
Khalili, H1
Yogaratnam, D1
Miller, MA1
Ross, B1
DiNapoli, M1
Ercan, U1
Kiraz, A1
Çikman, Ö1
Türkön, H1
Kilinç, N1
Otkun, MT1
Özkan, ÖF1
Kiraz, HA1
Karaayvaz, M1
Ribas Ripoll, V1
Romay, E1
Brunelli, L1
Pastorelli, R1
Goma, G1
Navas, A1
Artigas, A1
Ferrer, R1
Weiss, SL1
Haymond, S1
Ralay Ranaivo, H1
Wang, D1
De Jesus, VR1
Chace, DH1
Wainwright, MS1
Sjakste, N1
Baumane, L1
Boucher, JL1
Dzintare, M1
Meirena, D1
Sjakste, J1
Lauberte, L1
Kalvinsh, I1
Hayashi, N1
Yoshihara, D1
Kashiwabara, N1
Takeshita, Y1
Handa, H1
Yamakawa, M1
Biolo, G1
Toigo, G1
Ciocchi, B1
Situlin, R1
Iscra, F1
Gullo, A1
Guarnieri, G1
Penn, D2
Zhang, L2
Bobrowski, PJ2
Quinn, M2
Liu, X1
McDonough, KH2
Border, JR1
Burns, GP1
Rumph, C1
Schenk, WG1
Trumbeckaite, S1
Opalka, JR1
Neuhof, C1
Zierz, S1
Gellerich, FN1
Btaiche, IF1
Khalidi, N1
Wennberg, A1
Hyltander, A1
Sjöberg, A1
Arfvidsson, B1
Sandström, R1
Wickström, I1
Lundholm, K1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Calciuric Effect and Cyclic Parenteral Nutrition in Preterm Infants[NCT00711763]1 participants (Actual)Observational2008-07-31Terminated (stopped due to failure to recruit more patients and lack of supporting personnel.)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

9 reviews available for carnitine and Sepsis

ArticleYear
L-carnitine: Searching for New Therapeutic Strategy for Sepsis Management.
    Current medicinal chemistry, 2022, Volume: 29, Issue:18

    Topics: Carnitine; Fatty Acids; Humans; Sepsis; Shock, Septic

2022
The supplementation of L-carnitine in septic shock patients: Systematic review and meta-analysis.
    Clinics (Sao Paulo, Brazil), 2022, Volume: 77

    Topics: Adolescent; Adult; Carnitine; Dietary Supplements; Humans; Sepsis; Shock, Septic

2022
The Effect of L-Carnitine on Mortality Rate in Septic Patients: A Systematic Review and Meta-Analysis on Randomized Clinical Trials.
    Endocrine, metabolic & immune disorders drug targets, 2021, Volume: 21, Issue:4

    Topics: Carnitine; Dietary Supplements; Humans; Mortality; Randomized Controlled Trials as Topic; Sepsis; Tr

2021
Potential roles of mitochondrial cofactors in the adjuvant mitigation of proinflammatory acute infections, as in the case of sepsis and COVID-19 pneumonia.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2021, Volume: 70, Issue:2

    Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Carnitine; Chemotherapy, Adjuvant; COVID-19 Drug T

2021
A review of micronutrients in sepsis: the role of thiamine, l-carnitine, vitamin C, selenium and vitamin D.
    Nutrition research reviews, 2018, Volume: 31, Issue:2

    Topics: Ascorbic Acid; Carnitine; Deficiency Diseases; Dietary Supplements; Humans; Micronutrients; Nutritio

2018
Carnitine and sepsis: a review of an old clinical dilemma.
    Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques, 2013, Volume: 16, Issue:3

    Topics: Animals; Carnitine; Dietary Supplements; Humans; Sepsis

2013
Nutrition as medical therapy.
    Critical care nursing clinics of North America, 2014, Volume: 26, Issue:2

    Topics: Carnitine; Critical Care Nursing; Critical Illness; Humans; Insulin; Lipids; Nutrition Therapy; Pare

2014
Metabolic response to injury and sepsis: changes in protein metabolism.
    Nutrition (Burbank, Los Angeles County, Calif.), 1997, Volume: 13, Issue:9 Suppl

    Topics: Carnitine; Dipeptides; Humans; Nutritional Support; Proteins; Sepsis; Wounds and Injuries

1997
Parenteral nutrition-associated liver complications in children.
    Pharmacotherapy, 2002, Volume: 22, Issue:2

    Topics: Alkaline Phosphatase; Anti-Bacterial Agents; Bilirubin; Carnitine; Child; Cholestasis; gamma-Glutamy

2002

Trials

2 trials available for carnitine and Sepsis

ArticleYear
The effects of L-carnitine supplementation on inflammatory factors, oxidative stress, and clinical outcomes in patients with sepsis admitted to the intensive care unit (ICU): study protocol for a double blind, randomized, placebo-controlled clinical trial
    Trials, 2022, Feb-22, Volume: 23, Issue:1

    Topics: Adult; Aged; Carnitine; Dietary Supplements; Humans; Intensive Care Units; Iran; Middle Aged; Oxidat

2022
Prevalence of carnitine depletion in critically ill patients with undernutrition.
    Metabolism: clinical and experimental, 1992, Volume: 41, Issue:2

    Topics: Aged; Carnitine; Critical Illness; Female; Hemofiltration; Humans; Kidney Diseases; Liver Diseases;

1992

Other Studies

12 other studies available for carnitine and Sepsis

ArticleYear
Predictive value of presepsin and acylcarnitines for severity and biliary drainage in acute cholangitis.
    World journal of gastroenterology, 2023, Apr-28, Volume: 29, Issue:16

    Topics: Acetylcarnitine; Biomarkers; C-Reactive Protein; Carnitine; Cholangitis; Drainage; Humans; Lipopolys

2023
Increased Plasma Acetylcarnitine in Sepsis Is Associated With Multiple Organ Dysfunction and Mortality: A Multicenter Cohort Study.
    Critical care medicine, 2019, Volume: 47, Issue:2

    Topics: Acetylcarnitine; Aged; Biomarkers; Carnitine; Female; Humans; Male; Multiple Organ Failure; Proporti

2019
Bayesian Adaptive Randomization in Dose-Finding Trials.
    JAMA network open, 2018, 12-07, Volume: 1, Issue:8

    Topics: Bayes Theorem; Carnitine; Humans; Random Allocation; Sepsis; Shock, Septic

2018
The Effect of Systemic Carnitine Administration on Colon Anastomosis Healing in an Experimental Sepsis Model.
    Journal of investigative surgery : the official journal of the Academy of Surgical Research, 2015, Volume: 28, Issue:6

    Topics: Anastomosis, Surgical; Animals; Antioxidants; Carnitine; Colon; Disease Models, Animal; Hydroxyproli

2015
Metabolite analysis in sepsis through conditional independence maps.
    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference, 2015, Volume: 2015

    Topics: Adult; Aged; Algorithms; Bayes Theorem; Biomarkers; Carnitine; Computer Graphics; Critical Care; Fem

2015
Evaluation of asymmetric dimethylarginine, arginine, and carnitine metabolism in pediatric sepsis.
    Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2012, Volume: 13, Issue:4

    Topics: Adolescent; Arginine; Carnitine; Case-Control Studies; Child; Child, Preschool; Enzyme-Linked Immuno

2012
Effects of gamma-butyrobetaine and mildronate on nitric oxide production in lipopolysaccharide-treated rats.
    Basic & clinical pharmacology & toxicology, 2004, Volume: 94, Issue:1

    Topics: Adjuvants, Immunologic; Animals; Betaine; Carnitine; Lipopolysaccharides; Male; Methylhydrazines; Ni

2004
Effect of carnitine on decrease of branched chain amino acids and glutamine in serum of septic rats.
    Biological & pharmaceutical bulletin, 1996, Volume: 19, Issue:1

    Topics: Amino Acids, Branched-Chain; Animals; Carnitine; Endotoxins; Glutamine; Ketone Bodies; Male; Rats; R

1996
Carnitine deprivation adversely affects cardiovascular response to bacterial endotoxin (LPS) in the anesthetized neonatal pig.
    Shock (Augusta, Ga.), 1998, Volume: 10, Issue:5

    Topics: Anesthesia; Animals; Animals, Newborn; Blood Glucose; Blood Pressure; Cardiac Output; Cardiovascular

1998
Carnitine deprivation adversely affects cardiac performance in the lipopolysaccharide- and hypoxia/reoxygenation-stressed piglet heart.
    Shock (Augusta, Ga.), 1999, Volume: 11, Issue:2

    Topics: Animals; Animals, Newborn; Carnitine; Escherichia coli; Heart; Heart Rate; Hypoxia; In Vitro Techniq

1999
Carnitine levels in severe infection and starvation: a possible key to the prolonged catabolic state.
    Surgery, 1970, Volume: 68, Issue:1

    Topics: Animals; Carnitine; Dogs; Humans; Muscle, Skeletal; Sepsis; Starvation

1970
Different sensitivity of rabbit heart and skeletal muscle to endotoxin-induced impairment of mitochondrial function.
    European journal of biochemistry, 2001, Volume: 268, Issue:5

    Topics: Animals; Carnitine; Cell Respiration; Electron Transport; Female; Heart; In Vitro Techniques; Lipopo

2001