Page last updated: 2024-10-16
carnitine and Sepsis
carnitine has been researched along with Sepsis in 23 studies
Sepsis: Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "Because of the anti-inflammatory and antioxidant properties of L-carnitine, it is possible that using a high dose of 3000 mg daily of this nutritional supplement may reduce inflammation and oxidative stress and improve subsequent mortality of critically ill patients with sepsis." | 9.51 | The effects of L-carnitine supplementation on inflammatory factors, oxidative stress, and clinical outcomes in patients with sepsis admitted to the intensive care unit (ICU): study protocol for a double blind, randomized, placebo-controlled clinical trial ( Alikiaii, B; Askari, G; Bagherniya, M; Ferns, GA; Keshani, M; Yahyapoor, F, 2022) |
| "The precise role of carnitine as the key regulator of lipid metabolism in sepsis is unclear." | 8.89 | Carnitine and sepsis: a review of an old clinical dilemma. ( Elyasi, S; Farsaie, S; Hatamkhani, S; Karimzadeh, I; Khalili, H, 2013) |
| "To clarify the early predictive value of presepsin and acylcarnitines as biomarkers of severity of acute cholangitis and the need for biliary drainage." | 8.31 | Predictive value of presepsin and acylcarnitines for severity and biliary drainage in acute cholangitis. ( Li, CS; Lu, ZQ; Wang, GX; Xiao, HL; Xie, MR; Zhang, HY, 2023) |
| "We confirm that plasma acetylcarnitine can reflect the severity of organ dysfunction, inflammation, and infection in sepsis and can serve as a prognostic biomarker for mortality prediction." | 7.91 | Increased Plasma Acetylcarnitine in Sepsis Is Associated With Multiple Organ Dysfunction and Mortality: A Multicenter Cohort Study. ( Chang, HT; Chen, GY; Chen, YF; Chen, YJ; Chuang, TY; Chung, KP; Hsu, CL; Huang, MT; Huang, YT; Kuo, CH; Liu, WL; Yu, CJ, 2019) |
| "This study aimed to investigate the effects of L-carnitine, with its known antioxidant properties and positive effects on wound healing, on the healing of colon anastomosis in a cecal ligation and puncture sepsis model in rats." | 7.81 | The Effect of Systemic Carnitine Administration on Colon Anastomosis Healing in an Experimental Sepsis Model. ( Çikman, Ö; Ercan, U; Karaayvaz, M; Kilinç, N; Kiraz, A; Kiraz, HA; Otkun, MT; Özkan, ÖF; Türkön, H, 2015) |
| "Increased plasma concentrations of the endogenous nitric oxide synthase inhibitor, asymmetric dimethylarginine, decreased arginine bioavailability, and mitochondrial dysfunction have been reported in adult sepsis." | 7.78 | Evaluation of asymmetric dimethylarginine, arginine, and carnitine metabolism in pediatric sepsis. ( Chace, DH; De Jesus, VR; Haymond, S; Ralay Ranaivo, H; Wainwright, MS; Wang, D; Weiss, SL, 2012) |
| "L-carnitine is a potent antioxidant." | 6.82 | L-carnitine: Searching for New Therapeutic Strategy for Sepsis Management. ( Avan, R; Habtemariam, S; Hashemi, J; Monajati, M; Negintaji, S; Saghafi, F; Sahebnasagh, A, 2022) |
| "Sepsis is defined as the dysregulated host response to an infection resulting in life-threatening organ dysfunction." | 6.58 | A review of micronutrients in sepsis: the role of thiamine, l-carnitine, vitamin C, selenium and vitamin D. ( Belsky, JB; Jacob, V; Lee, PJ; Sather, JE; Wira, CR, 2018) |
| "Because of the anti-inflammatory and antioxidant properties of L-carnitine, it is possible that using a high dose of 3000 mg daily of this nutritional supplement may reduce inflammation and oxidative stress and improve subsequent mortality of critically ill patients with sepsis." | 5.51 | The effects of L-carnitine supplementation on inflammatory factors, oxidative stress, and clinical outcomes in patients with sepsis admitted to the intensive care unit (ICU): study protocol for a double blind, randomized, placebo-controlled clinical trial ( Alikiaii, B; Askari, G; Bagherniya, M; Ferns, GA; Keshani, M; Yahyapoor, F, 2022) |
| "Recent clinical trial studies have reported that L-carnitine supplementation can reduce the mortality rate in patients with sepsis, but there are no definitive results in this context." | 5.12 | The Effect of L-Carnitine on Mortality Rate in Septic Patients: A Systematic Review and Meta-Analysis on Randomized Clinical Trials. ( Abdolahi, M; Abdollahi, H; Jafarieh, A; Sedighiyan, M, 2021) |
| "The aim of this study was to evaluate to what extent secondary carnitine deficiency may exist based on the prevalence of subnormal carnitine status in patients with critical illness and abnormal nutritional state." | 5.07 | Prevalence of carnitine depletion in critically ill patients with undernutrition. ( Arfvidsson, B; Hyltander, A; Lundholm, K; Sandström, R; Sjöberg, A; Wennberg, A; Wickström, I, 1992) |
| " This article reviews some of the pharmacologic roles that parenteral nutritional ingredients (selenium, lipid emulsion, insulin, and levocarnitine) can play in the setting of critical illness." | 4.90 | Nutrition as medical therapy. ( DiNapoli, M; Miller, MA; Ross, B; Yogaratnam, D, 2014) |
| "The precise role of carnitine as the key regulator of lipid metabolism in sepsis is unclear." | 4.89 | Carnitine and sepsis: a review of an old clinical dilemma. ( Elyasi, S; Farsaie, S; Hatamkhani, S; Karimzadeh, I; Khalili, H, 2013) |
| "To clarify the early predictive value of presepsin and acylcarnitines as biomarkers of severity of acute cholangitis and the need for biliary drainage." | 4.31 | Predictive value of presepsin and acylcarnitines for severity and biliary drainage in acute cholangitis. ( Li, CS; Lu, ZQ; Wang, GX; Xiao, HL; Xie, MR; Zhang, HY, 2023) |
| "We confirm that plasma acetylcarnitine can reflect the severity of organ dysfunction, inflammation, and infection in sepsis and can serve as a prognostic biomarker for mortality prediction." | 3.91 | Increased Plasma Acetylcarnitine in Sepsis Is Associated With Multiple Organ Dysfunction and Mortality: A Multicenter Cohort Study. ( Chang, HT; Chen, GY; Chen, YF; Chen, YJ; Chuang, TY; Chung, KP; Hsu, CL; Huang, MT; Huang, YT; Kuo, CH; Liu, WL; Yu, CJ, 2019) |
| "This study aimed to investigate the effects of L-carnitine, with its known antioxidant properties and positive effects on wound healing, on the healing of colon anastomosis in a cecal ligation and puncture sepsis model in rats." | 3.81 | The Effect of Systemic Carnitine Administration on Colon Anastomosis Healing in an Experimental Sepsis Model. ( Çikman, Ö; Ercan, U; Karaayvaz, M; Kilinç, N; Kiraz, A; Kiraz, HA; Otkun, MT; Özkan, ÖF; Türkön, H, 2015) |
| "Increased plasma concentrations of the endogenous nitric oxide synthase inhibitor, asymmetric dimethylarginine, decreased arginine bioavailability, and mitochondrial dysfunction have been reported in adult sepsis." | 3.78 | Evaluation of asymmetric dimethylarginine, arginine, and carnitine metabolism in pediatric sepsis. ( Chace, DH; De Jesus, VR; Haymond, S; Ralay Ranaivo, H; Wainwright, MS; Wang, D; Weiss, SL, 2012) |
| "Blood concentrations of branched chain amino acids (BCAA; leucine, isoleucine, and valine) and glutamine (Gln) decrease markedly in sepsis." | 3.69 | Effect of carnitine on decrease of branched chain amino acids and glutamine in serum of septic rats. ( Handa, H; Hayashi, N; Kashiwabara, N; Takeshita, Y; Yamakawa, M; Yoshihara, D, 1996) |
| "L-carnitine is a potent antioxidant." | 2.82 | L-carnitine: Searching for New Therapeutic Strategy for Sepsis Management. ( Avan, R; Habtemariam, S; Hashemi, J; Monajati, M; Negintaji, S; Saghafi, F; Sahebnasagh, A, 2022) |
| "Sepsis and septic shock are severe and difficult-to-treat conditions with high lethality." | 2.82 | The supplementation of L-carnitine in septic shock patients: Systematic review and meta-analysis. ( Guedes, GV; Minicucci, MF; Tanni, SE, 2022) |
| "Sepsis is defined as the dysregulated host response to an infection resulting in life-threatening organ dysfunction." | 2.58 | A review of micronutrients in sepsis: the role of thiamine, l-carnitine, vitamin C, selenium and vitamin D. ( Belsky, JB; Jacob, V; Lee, PJ; Sather, JE; Wira, CR, 2018) |
| "The metabolic response to trauma and sepsis involves an increased loss of body proteins." | 2.40 | Metabolic response to injury and sepsis: changes in protein metabolism. ( Biolo, G; Ciocchi, B; Guarnieri, G; Gullo, A; Iscra, F; Situlin, R; Toigo, G, 1997) |
| "Sepsis is the response of the host to an infection that produces lesions in its own organs and tissues." | 1.42 | Metabolite analysis in sepsis through conditional independence maps. ( Artigas, A; Brunelli, L; Ferrer, R; Goma, G; Navas, A; Pastorelli, R; Ribas Ripoll, V; Romay, E, 2015) |
| " In heart fibers a dosage of 100 microg LPS." | 1.31 | Different sensitivity of rabbit heart and skeletal muscle to endotoxin-induced impairment of mitochondrial function. ( Gellerich, FN; Neuhof, C; Opalka, JR; Trumbeckaite, S; Zierz, S, 2001) |
Research
Studies (23)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.35) | 18.7374 |
| 1990's | 5 (21.74) | 18.2507 |
| 2000's | 3 (13.04) | 29.6817 |
| 2010's | 8 (34.78) | 24.3611 |
| 2020's | 6 (26.09) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Sahebnasagh, A | 1 |
| Avan, R | 1 |
| Monajati, M | 1 |
| Hashemi, J | 1 |
| Habtemariam, S | 1 |
| Negintaji, S | 1 |
| Saghafi, F | 1 |
| Keshani, M | 1 |
| Alikiaii, B | 1 |
| Askari, G | 1 |
| Yahyapoor, F | 1 |
| Ferns, GA | 1 |
| Bagherniya, M | 1 |
| Guedes, GV | 1 |
| Minicucci, MF | 1 |
| Tanni, SE | 1 |
| Zhang, HY | 1 |
| Xiao, HL | 1 |
| Wang, GX | 1 |
| Lu, ZQ | 1 |
| Xie, MR | 1 |
| Li, CS | 1 |
| Abdollahi, H | 1 |
| Abdolahi, M | 1 |
| Sedighiyan, M | 1 |
| Jafarieh, A | 1 |
| Pagano, G | 1 |
| Manfredi, C | 1 |
| Pallardó, FV | 1 |
| Lyakhovich, A | 1 |
| Tiano, L | 1 |
| Trifuoggi, M | 1 |
| Belsky, JB | 1 |
| Wira, CR | 1 |
| Jacob, V | 1 |
| Sather, JE | 1 |
| Lee, PJ | 1 |
| Chung, KP | 1 |
| Chen, GY | 1 |
| Chuang, TY | 1 |
| Huang, YT | 1 |
| Chang, HT | 1 |
| Chen, YF | 1 |
| Liu, WL | 1 |
| Chen, YJ | 1 |
| Hsu, CL | 1 |
| Huang, MT | 1 |
| Kuo, CH | 1 |
| Yu, CJ | 1 |
| Ventz, S | 1 |
| Alexander, BM | 1 |
| Trippa, L | 1 |
| Hatamkhani, S | 1 |
| Karimzadeh, I | 1 |
| Elyasi, S | 1 |
| Farsaie, S | 1 |
| Khalili, H | 1 |
| Yogaratnam, D | 1 |
| Miller, MA | 1 |
| Ross, B | 1 |
| DiNapoli, M | 1 |
| Ercan, U | 1 |
| Kiraz, A | 1 |
| Çikman, Ö | 1 |
| Türkön, H | 1 |
| Kilinç, N | 1 |
| Otkun, MT | 1 |
| Özkan, ÖF | 1 |
| Kiraz, HA | 1 |
| Karaayvaz, M | 1 |
| Ribas Ripoll, V | 1 |
| Romay, E | 1 |
| Brunelli, L | 1 |
| Pastorelli, R | 1 |
| Goma, G | 1 |
| Navas, A | 1 |
| Artigas, A | 1 |
| Ferrer, R | 1 |
| Weiss, SL | 1 |
| Haymond, S | 1 |
| Ralay Ranaivo, H | 1 |
| Wang, D | 1 |
| De Jesus, VR | 1 |
| Chace, DH | 1 |
| Wainwright, MS | 1 |
| Sjakste, N | 1 |
| Baumane, L | 1 |
| Boucher, JL | 1 |
| Dzintare, M | 1 |
| Meirena, D | 1 |
| Sjakste, J | 1 |
| Lauberte, L | 1 |
| Kalvinsh, I | 1 |
| Hayashi, N | 1 |
| Yoshihara, D | 1 |
| Kashiwabara, N | 1 |
| Takeshita, Y | 1 |
| Handa, H | 1 |
| Yamakawa, M | 1 |
| Biolo, G | 1 |
| Toigo, G | 1 |
| Ciocchi, B | 1 |
| Situlin, R | 1 |
| Iscra, F | 1 |
| Gullo, A | 1 |
| Guarnieri, G | 1 |
| Penn, D | 2 |
| Zhang, L | 2 |
| Bobrowski, PJ | 2 |
| Quinn, M | 2 |
| Liu, X | 1 |
| McDonough, KH | 2 |
| Border, JR | 1 |
| Burns, GP | 1 |
| Rumph, C | 1 |
| Schenk, WG | 1 |
| Trumbeckaite, S | 1 |
| Opalka, JR | 1 |
| Neuhof, C | 1 |
| Zierz, S | 1 |
| Gellerich, FN | 1 |
| Btaiche, IF | 1 |
| Khalidi, N | 1 |
| Wennberg, A | 1 |
| Hyltander, A | 1 |
| Sjöberg, A | 1 |
| Arfvidsson, B | 1 |
| Sandström, R | 1 |
| Wickström, I | 1 |
| Lundholm, K | 1 |
Clinical Trials (1)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Calciuric Effect and Cyclic Parenteral Nutrition in Preterm Infants[NCT00711763] | 1 participants (Actual) | Observational | 2008-07-31 | Terminated (stopped due to failure to recruit more patients and lack of supporting personnel.) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Reviews
9 reviews available for carnitine and Sepsis
| Article | Year |
|---|---|
L-carnitine: Searching for New Therapeutic Strategy for Sepsis Management.
Topics: Carnitine; Fatty Acids; Humans; Sepsis; Shock, Septic | 2022 |
The supplementation of L-carnitine in septic shock patients: Systematic review and meta-analysis.
Topics: Adolescent; Adult; Carnitine; Dietary Supplements; Humans; Sepsis; Shock, Septic | 2022 |
The Effect of L-Carnitine on Mortality Rate in Septic Patients: A Systematic Review and Meta-Analysis on Randomized Clinical Trials.
Topics: Carnitine; Dietary Supplements; Humans; Mortality; Randomized Controlled Trials as Topic; Sepsis; Tr | 2021 |
Potential roles of mitochondrial cofactors in the adjuvant mitigation of proinflammatory acute infections, as in the case of sepsis and COVID-19 pneumonia.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Carnitine; Chemotherapy, Adjuvant; COVID-19 Drug T | 2021 |
A review of micronutrients in sepsis: the role of thiamine, l-carnitine, vitamin C, selenium and vitamin D.
Topics: Ascorbic Acid; Carnitine; Deficiency Diseases; Dietary Supplements; Humans; Micronutrients; Nutritio | 2018 |
Carnitine and sepsis: a review of an old clinical dilemma.
Topics: Animals; Carnitine; Dietary Supplements; Humans; Sepsis | 2013 |
Nutrition as medical therapy.
Topics: Carnitine; Critical Care Nursing; Critical Illness; Humans; Insulin; Lipids; Nutrition Therapy; Pare | 2014 |
Metabolic response to injury and sepsis: changes in protein metabolism.
Topics: Carnitine; Dipeptides; Humans; Nutritional Support; Proteins; Sepsis; Wounds and Injuries | 1997 |
Parenteral nutrition-associated liver complications in children.
Topics: Alkaline Phosphatase; Anti-Bacterial Agents; Bilirubin; Carnitine; Child; Cholestasis; gamma-Glutamy | 2002 |
Trials
2 trials available for carnitine and Sepsis
| Article | Year |
|---|---|
The effects of L-carnitine supplementation on inflammatory factors, oxidative stress, and clinical outcomes in patients with sepsis admitted to the intensive care unit (ICU): study protocol for a double blind, randomized, placebo-controlled clinical trial
Topics: Adult; Aged; Carnitine; Dietary Supplements; Humans; Intensive Care Units; Iran; Middle Aged; Oxidat | 2022 |
Prevalence of carnitine depletion in critically ill patients with undernutrition.
Topics: Aged; Carnitine; Critical Illness; Female; Hemofiltration; Humans; Kidney Diseases; Liver Diseases; | 1992 |
Other Studies
12 other studies available for carnitine and Sepsis
| Article | Year |
|---|---|
Predictive value of presepsin and acylcarnitines for severity and biliary drainage in acute cholangitis.
Topics: Acetylcarnitine; Biomarkers; C-Reactive Protein; Carnitine; Cholangitis; Drainage; Humans; Lipopolys | 2023 |
Increased Plasma Acetylcarnitine in Sepsis Is Associated With Multiple Organ Dysfunction and Mortality: A Multicenter Cohort Study.
Topics: Acetylcarnitine; Aged; Biomarkers; Carnitine; Female; Humans; Male; Multiple Organ Failure; Proporti | 2019 |
Bayesian Adaptive Randomization in Dose-Finding Trials.
Topics: Bayes Theorem; Carnitine; Humans; Random Allocation; Sepsis; Shock, Septic | 2018 |
The Effect of Systemic Carnitine Administration on Colon Anastomosis Healing in an Experimental Sepsis Model.
Topics: Anastomosis, Surgical; Animals; Antioxidants; Carnitine; Colon; Disease Models, Animal; Hydroxyproli | 2015 |
Metabolite analysis in sepsis through conditional independence maps.
Topics: Adult; Aged; Algorithms; Bayes Theorem; Biomarkers; Carnitine; Computer Graphics; Critical Care; Fem | 2015 |
Evaluation of asymmetric dimethylarginine, arginine, and carnitine metabolism in pediatric sepsis.
Topics: Adolescent; Arginine; Carnitine; Case-Control Studies; Child; Child, Preschool; Enzyme-Linked Immuno | 2012 |
Effects of gamma-butyrobetaine and mildronate on nitric oxide production in lipopolysaccharide-treated rats.
Topics: Adjuvants, Immunologic; Animals; Betaine; Carnitine; Lipopolysaccharides; Male; Methylhydrazines; Ni | 2004 |
Effect of carnitine on decrease of branched chain amino acids and glutamine in serum of septic rats.
Topics: Amino Acids, Branched-Chain; Animals; Carnitine; Endotoxins; Glutamine; Ketone Bodies; Male; Rats; R | 1996 |
Carnitine deprivation adversely affects cardiovascular response to bacterial endotoxin (LPS) in the anesthetized neonatal pig.
Topics: Anesthesia; Animals; Animals, Newborn; Blood Glucose; Blood Pressure; Cardiac Output; Cardiovascular | 1998 |
Carnitine deprivation adversely affects cardiac performance in the lipopolysaccharide- and hypoxia/reoxygenation-stressed piglet heart.
Topics: Animals; Animals, Newborn; Carnitine; Escherichia coli; Heart; Heart Rate; Hypoxia; In Vitro Techniq | 1999 |
Carnitine levels in severe infection and starvation: a possible key to the prolonged catabolic state.
Topics: Animals; Carnitine; Dogs; Humans; Muscle, Skeletal; Sepsis; Starvation | 1970 |
Different sensitivity of rabbit heart and skeletal muscle to endotoxin-induced impairment of mitochondrial function.
Topics: Animals; Carnitine; Cell Respiration; Electron Transport; Female; Heart; In Vitro Techniques; Lipopo | 2001 |