busulfan has been researched along with Aging in 27 studies
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
Excerpt | Relevance | Reference |
---|---|---|
" In adults, pharmacodynamic studies have shown a positive correlation between high-systemic exposure of the drug and venocclusive disease (VOD)." | 2.39 | Aspects concerning busulfan pharmacokinetics and bioavailability. ( Ehrsson, H; Hassan, M; Ljungman, P, 1996) |
"Cataracts affect a minority of long-term cancer survivors, but those who reported them were more likely to report that cancer had had a lasting effect on their overall health." | 1.33 | Cataracts among cancer survivors. ( Beck, M; Stava, C; Vassilopoulou-Sellin, R, 2005) |
" The elimination half-life for the last dose in young children was shorter (2." | 1.28 | Pharmacokinetics of high-dose busulphan in relation to age and chronopharmacology. ( Aschan, J; Bekassy, AN; Ehrsson, H; Hassan, M; Ljungman, P; Lönnerholm, G; Oberg, G; Smedmyr, B; Taube, A; Wallin, I, 1991) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 11 (40.74) | 18.7374 |
1990's | 5 (18.52) | 18.2507 |
2000's | 5 (18.52) | 29.6817 |
2010's | 5 (18.52) | 24.3611 |
2020's | 1 (3.70) | 2.80 |
Authors | Studies |
---|---|
Wei, R | 1 |
Zhang, X | 1 |
Cai, Y | 1 |
Liu, H | 1 |
Wang, B | 1 |
Zhao, X | 1 |
Zou, K | 1 |
Kang, Z | 1 |
Qiao, N | 1 |
Tan, Z | 1 |
Tang, Z | 1 |
Li, Y | 1 |
Jiang, Y | 1 |
Zhao, J | 1 |
Qi, HJ | 1 |
Li, XL | 1 |
Zhang, SR | 1 |
Song, DW | 1 |
Yu, CY | 1 |
Gao, JG | 1 |
Koreth, J | 1 |
Aldridge, J | 1 |
Kim, HT | 1 |
Alyea, EP | 1 |
Cutler, C | 1 |
Armand, P | 1 |
Ritz, J | 1 |
Antin, JH | 1 |
Soiffer, RJ | 1 |
Ho, VT | 1 |
Takahata, M | 1 |
Hashino, S | 1 |
Okada, K | 1 |
Onozawa, M | 1 |
Kahata, K | 1 |
Sugita, J | 1 |
Shigematsu, A | 1 |
Kondo, T | 1 |
Yamamoto, S | 1 |
Endo, T | 1 |
Nishio, M | 1 |
Ito, YM | 1 |
Tanaka, J | 1 |
Koike, T | 1 |
Asaka, M | 1 |
Imamura, M | 1 |
Lacerda, SM | 1 |
Batlouni, SR | 1 |
Costa, GM | 1 |
Segatelli, TM | 1 |
Quirino, BR | 1 |
Queiroz, BM | 1 |
Kalapothakis, E | 1 |
França, LR | 1 |
CONKLIN, JW | 1 |
UPTON, AC | 1 |
CHRISTENBERRY, KW | 1 |
Spradling, AC | 1 |
Johnson, J | 1 |
Canning, J | 1 |
Kaneko, T | 1 |
Pru, JK | 1 |
Tilly, JL | 1 |
Stava, C | 1 |
Beck, M | 1 |
Vassilopoulou-Sellin, R | 1 |
Ehmcke, J | 1 |
Joshi, B | 1 |
Hergenrother, SD | 1 |
Schlatt, S | 1 |
Seandel, M | 1 |
James, D | 1 |
Shmelkov, SV | 1 |
Falciatori, I | 1 |
Kim, J | 1 |
Chavala, S | 1 |
Scherr, DS | 1 |
Zhang, F | 1 |
Torres, R | 1 |
Gale, NW | 1 |
Yancopoulos, GD | 1 |
Murphy, A | 1 |
Valenzuela, DM | 1 |
Hobbs, RM | 1 |
Pandolfi, PP | 1 |
Rafii, S | 1 |
Light, AE | 1 |
Deeg, HJ | 1 |
Storb, R | 1 |
Prentice, R | 1 |
Fritz, TE | 1 |
Weiden, PL | 1 |
Sale, GE | 1 |
Graham, TC | 1 |
Thomas, ED | 1 |
Zenzes, MT | 1 |
Engel, W | 1 |
Hassan, M | 2 |
Ehrsson, H | 2 |
Ljungman, P | 2 |
Gibbs, JP | 1 |
Murray, G | 1 |
Risler, L | 1 |
Chien, JY | 1 |
Dev, R | 1 |
Slattery, JT | 1 |
Sekine, I | 1 |
Fukuda, H | 1 |
Kunitoh, H | 1 |
Saijo, N | 1 |
Jonsson, CK | 1 |
Zetterström, RH | 1 |
Holst, M | 1 |
Parvinen, M | 1 |
Söder, O | 1 |
Popp, DM | 1 |
Popp, RA | 1 |
Oberg, G | 1 |
Bekassy, AN | 1 |
Aschan, J | 1 |
Lönnerholm, G | 1 |
Smedmyr, B | 1 |
Taube, A | 1 |
Wallin, I | 1 |
Krawczyk, Z | 1 |
Szymik, N | 1 |
Reynolds, M | 1 |
McCann, SR | 1 |
Kasuga, F | 1 |
Takahashi, M | 1 |
Jansz, GF | 1 |
Pomerantz, DK | 1 |
Gresham, PA | 1 |
Pover, WF | 1 |
Reizenstein, P | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
CD133+ Autologue Transplantation to Promote Ovarian Follicles Development in Women With Poor Ovarian Reserve.[NCT01966536] | 0 participants (Actual) | Interventional | 2013-11-30 | Withdrawn (stopped due to Due to fundamental changes in procedures design no patients have been enrolled) | |||
Antioxidants vs.Ovarian Bio-stimulation Therapy to Rescue the Ovarian Reserve[NCT03621683] | 78 participants (Actual) | Interventional | 2016-01-06 | Completed | |||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
3 reviews available for busulfan and Aging
Article | Year |
---|---|
Aspects concerning busulfan pharmacokinetics and bioavailability.
Topics: Adolescent; Adult; Aging; Animals; Biological Availability; Biotransformation; Bone Marrow Transplan | 1996 |
Cancer chemotherapy in the elderly.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anthraquinones; Antineoplastic Agents; Breast Neo | 1998 |
Hemopoietic stem cell heterogeneity: use of cell cycle-specific drugs to look for age-associated alterations.
Topics: Aging; Animals; Antineoplastic Agents; Bone Marrow; Bone Marrow Transplantation; Busulfan; Cell Cycl | 1979 |
24 other studies available for busulfan and Aging
Article | Year |
---|---|
Busulfan Suppresses Autophagy in Mouse Spermatogonial Progenitor Cells via mTOR of AKT and p53 Signaling Pathways.
Topics: Aging; Animals; Autophagy; Busulfan; Cell Survival; Cells, Cultured; Gene Expression Profiling; Male | 2020 |
Expression patterns and changes of the LCN2 gene in the testes of induced cryptorchidism and busulfan-treated mice.
Topics: Aging; Animals; Busulfan; Cryptorchidism; Gene Expression; In Situ Hybridization; Infertility, Male; | 2017 |
Accelerated ovarian aging in mice by treatment of busulfan and cyclophosphamide.
Topics: Aging; Animals; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; B | 2013 |
Reduced-intensity conditioning hematopoietic stem cell transplantation in patients over 60 years: hematologic malignancy outcomes are not impaired in advanced age.
Topics: Age Factors; Aged; Aging; Blood Donors; Busulfan; Disease-Free Survival; Female; Graft vs Host Disea | 2010 |
Reduced intensity conditioning regimen with fludarabine, busulfan, and low-dose TBI (Flu-BU2-TBI): clinical efficacy in high-risk patients.
Topics: Adult; Aged; Aging; Busulfan; Hematopoietic Stem Cell Transplantation; Humans; Middle Aged; Myeloabl | 2010 |
A new and fast technique to generate offspring after germ cells transplantation in adult fish: the Nile tilapia (Oreochromis niloticus) model.
Topics: Aging; Animals; Animals, Genetically Modified; Breeding; Busulfan; Cichlids; Cryopreservation; Male; | 2010 |
FURTHER OBSERVATIONS ON LATE SOMATIC EFFECTS OF RADIOMIMETIC CHEMICALS AND X-RAYS IN MICE.
Topics: Aging; Busulfan; Cataract; Female; Humans; Leukemia; Leukemia, Myeloid; Longevity; Lung Neoplasms; L | 1965 |
Stem cells: more like a man.
Topics: Aging; Animals; Biomarkers; Busulfan; Cell Count; Cell Differentiation; Cell Division; Female; Male; | 2004 |
Germline stem cells and follicular renewal in the postnatal mammalian ovary.
Topics: Aging; Animals; Biomarkers; Busulfan; Cell Count; Cell Differentiation; Cell Division; Female; Gene | 2004 |
Germline stem cells and follicular renewal in the postnatal mammalian ovary.
Topics: Aging; Animals; Biomarkers; Busulfan; Cell Count; Cell Differentiation; Cell Division; Female; Gene | 2004 |
Germline stem cells and follicular renewal in the postnatal mammalian ovary.
Topics: Aging; Animals; Biomarkers; Busulfan; Cell Count; Cell Differentiation; Cell Division; Female; Gene | 2004 |
Germline stem cells and follicular renewal in the postnatal mammalian ovary.
Topics: Aging; Animals; Biomarkers; Busulfan; Cell Count; Cell Differentiation; Cell Division; Female; Gene | 2004 |
Cataracts among cancer survivors.
Topics: Adrenal Cortex Hormones; Adult; Aging; Bone Marrow Transplantation; Breast Neoplasms; Busulfan; Cata | 2005 |
Aging does not affect spermatogenic recovery after experimentally induced injury in mice.
Topics: Aging; Alkylating Agents; Animals; Busulfan; Cell Nucleus; Cold Temperature; Male; Mice; Mice, Inbre | 2007 |
Generation of functional multipotent adult stem cells from GPR125+ germline progenitors.
Topics: Adult Stem Cells; Aging; Animals; Blood Vessels; Busulfan; Cell Differentiation; Cell Line; Gene Exp | 2007 |
Additional observations on the effects of busulfan on cataract formation, duration of anesthesia, and reproduction in rats.
Topics: Aging; Anesthesia; Animals; Animals, Newborn; Busulfan; Cataract; Diet; Female; Male; Pregnancy; Rat | 1967 |
Increased cancer risk in canine radiation chimeras.
Topics: Aging; Animals; Bone Marrow Transplantation; Busulfan; Central Nervous System Diseases; Cyclophospha | 1980 |
The capacity of testicular cells of the postnatal rat to reorganize into histotypic structures.
Topics: Aging; Animals; Busulfan; Cells, Cultured; Female; Male; Morphogenesis; Ovary; Rats; Testis | 1981 |
Age-dependent tetrahydrothiophenium ion formation in young children and adults receiving high-dose busulfan.
Topics: Absorption; Administration, Oral; Adolescent; Adult; Aging; Antineoplastic Agents, Alkylating; Area | 1997 |
Constitutive expression of interleukin-1alpha messenger ribonucleic acid in rat Sertoli cells is dependent upon interaction with germ cells.
Topics: Aging; Animals; Busulfan; Cells, Cultured; Gene Expression Regulation, Developmental; Interleukin-1; | 1999 |
Pharmacokinetics of high-dose busulphan in relation to age and chronopharmacology.
Topics: Adolescent; Adult; Aging; Busulfan; Child; Child, Preschool; Chronobiology Phenomena; Circadian Rhyt | 1991 |
Effect of age and busulphan treatment on the hsp70 gene-related transcript level in rat testes.
Topics: Aging; Animals; Blotting, Northern; Busulfan; Heat-Shock Proteins; Male; Rats; Rats, Inbred Strains; | 1989 |
Sequential studies of bone marrow haemopoietic progenitors (CFU-GEM, BFU-E, CFU-E, CFU-GM) following busulfan treatment in Balb/c mice.
Topics: Aging; Animals; Bone Marrow; Bone Marrow Cells; Busulfan; Cells, Cultured; Hematocrit; Hematopoietic | 1986 |
The endocrine function of rat gonads with reduced number of germ cells following busulphan treatment.
Topics: Aging; Animals; Body Weight; Busulfan; Chorionic Gonadotropin; Estradiol; Female; Fetus; Male; Organ | 1986 |
The effect of prenatal treatment with busulfan on in vitro androgen production by testes from rats of various ages.
Topics: Aging; Androgens; Animals; Body Weight; Busulfan; Female; Luteinizing Hormone; Male; Maternal-Fetal | 1985 |
Neuroendocrine reactions and the radiation-induced variations in rat intestinal alkaline ribonuclease levels.
Topics: Adrenocorticotropic Hormone; Aging; Alkalies; Animals; Busulfan; Chlorambucil; Endocrine Glands; Fem | 1968 |
Errors and artefacts in serum folic-acid assays. Effects of age, food, drugs and radiation.
Topics: Aging; Anti-Bacterial Agents; Biological Assay; Blood Chemical Analysis; Busulfan; Chloroquine; Diet | 1965 |