busulfan and Aging
busulfan has been researched along with Aging in 27 studies
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| " In adults, pharmacodynamic studies have shown a positive correlation between high-systemic exposure of the drug and venocclusive disease (VOD)." | 2.39 | Aspects concerning busulfan pharmacokinetics and bioavailability. ( Ehrsson, H; Hassan, M; Ljungman, P, 1996) |
| "Cataracts affect a minority of long-term cancer survivors, but those who reported them were more likely to report that cancer had had a lasting effect on their overall health." | 1.33 | Cataracts among cancer survivors. ( Beck, M; Stava, C; Vassilopoulou-Sellin, R, 2005) |
| " The elimination half-life for the last dose in young children was shorter (2." | 1.28 | Pharmacokinetics of high-dose busulphan in relation to age and chronopharmacology. ( Aschan, J; Bekassy, AN; Ehrsson, H; Hassan, M; Ljungman, P; Lönnerholm, G; Oberg, G; Smedmyr, B; Taube, A; Wallin, I, 1991) |
Research
Studies (27)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (40.74) | 18.7374 |
| 1990's | 5 (18.52) | 18.2507 |
| 2000's | 5 (18.52) | 29.6817 |
| 2010's | 5 (18.52) | 24.3611 |
| 2020's | 1 (3.70) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Wei, R | 1 |
| Zhang, X | 1 |
| Cai, Y | 1 |
| Liu, H | 1 |
| Wang, B | 1 |
| Zhao, X | 1 |
| Zou, K | 1 |
| Kang, Z | 1 |
| Qiao, N | 1 |
| Tan, Z | 1 |
| Tang, Z | 1 |
| Li, Y | 1 |
| Jiang, Y | 1 |
| Zhao, J | 1 |
| Qi, HJ | 1 |
| Li, XL | 1 |
| Zhang, SR | 1 |
| Song, DW | 1 |
| Yu, CY | 1 |
| Gao, JG | 1 |
| Koreth, J | 1 |
| Aldridge, J | 1 |
| Kim, HT | 1 |
| Alyea, EP | 1 |
| Cutler, C | 1 |
| Armand, P | 1 |
| Ritz, J | 1 |
| Antin, JH | 1 |
| Soiffer, RJ | 1 |
| Ho, VT | 1 |
| Takahata, M | 1 |
| Hashino, S | 1 |
| Okada, K | 1 |
| Onozawa, M | 1 |
| Kahata, K | 1 |
| Sugita, J | 1 |
| Shigematsu, A | 1 |
| Kondo, T | 1 |
| Yamamoto, S | 1 |
| Endo, T | 1 |
| Nishio, M | 1 |
| Ito, YM | 1 |
| Tanaka, J | 1 |
| Koike, T | 1 |
| Asaka, M | 1 |
| Imamura, M | 1 |
| Lacerda, SM | 1 |
| Batlouni, SR | 1 |
| Costa, GM | 1 |
| Segatelli, TM | 1 |
| Quirino, BR | 1 |
| Queiroz, BM | 1 |
| Kalapothakis, E | 1 |
| França, LR | 1 |
| CONKLIN, JW | 1 |
| UPTON, AC | 1 |
| CHRISTENBERRY, KW | 1 |
| Spradling, AC | 1 |
| Johnson, J | 1 |
| Canning, J | 1 |
| Kaneko, T | 1 |
| Pru, JK | 1 |
| Tilly, JL | 1 |
| Stava, C | 1 |
| Beck, M | 1 |
| Vassilopoulou-Sellin, R | 1 |
| Ehmcke, J | 1 |
| Joshi, B | 1 |
| Hergenrother, SD | 1 |
| Schlatt, S | 1 |
| Seandel, M | 1 |
| James, D | 1 |
| Shmelkov, SV | 1 |
| Falciatori, I | 1 |
| Kim, J | 1 |
| Chavala, S | 1 |
| Scherr, DS | 1 |
| Zhang, F | 1 |
| Torres, R | 1 |
| Gale, NW | 1 |
| Yancopoulos, GD | 1 |
| Murphy, A | 1 |
| Valenzuela, DM | 1 |
| Hobbs, RM | 1 |
| Pandolfi, PP | 1 |
| Rafii, S | 1 |
| Light, AE | 1 |
| Deeg, HJ | 1 |
| Storb, R | 1 |
| Prentice, R | 1 |
| Fritz, TE | 1 |
| Weiden, PL | 1 |
| Sale, GE | 1 |
| Graham, TC | 1 |
| Thomas, ED | 1 |
| Zenzes, MT | 1 |
| Engel, W | 1 |
| Hassan, M | 2 |
| Ehrsson, H | 2 |
| Ljungman, P | 2 |
| Gibbs, JP | 1 |
| Murray, G | 1 |
| Risler, L | 1 |
| Chien, JY | 1 |
| Dev, R | 1 |
| Slattery, JT | 1 |
| Sekine, I | 1 |
| Fukuda, H | 1 |
| Kunitoh, H | 1 |
| Saijo, N | 1 |
| Jonsson, CK | 1 |
| Zetterström, RH | 1 |
| Holst, M | 1 |
| Parvinen, M | 1 |
| Söder, O | 1 |
| Popp, DM | 1 |
| Popp, RA | 1 |
| Oberg, G | 1 |
| Bekassy, AN | 1 |
| Aschan, J | 1 |
| Lönnerholm, G | 1 |
| Smedmyr, B | 1 |
| Taube, A | 1 |
| Wallin, I | 1 |
| Krawczyk, Z | 1 |
| Szymik, N | 1 |
| Reynolds, M | 1 |
| McCann, SR | 1 |
| Kasuga, F | 1 |
| Takahashi, M | 1 |
| Jansz, GF | 1 |
| Pomerantz, DK | 1 |
| Gresham, PA | 1 |
| Pover, WF | 1 |
| Reizenstein, P | 1 |
Clinical Trials (2)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| CD133+ Autologue Transplantation to Promote Ovarian Follicles Development in Women With Poor Ovarian Reserve.[NCT01966536] | 0 participants (Actual) | Interventional | 2013-11-30 | Withdrawn (stopped due to Due to fundamental changes in procedures design no patients have been enrolled) | |||
| Antioxidants vs.Ovarian Bio-stimulation Therapy to Rescue the Ovarian Reserve[NCT03621683] | 78 participants (Actual) | Interventional | 2016-01-06 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Reviews
3 reviews available for busulfan and Aging
| Article | Year |
|---|---|
Aspects concerning busulfan pharmacokinetics and bioavailability.
Topics: Adolescent; Adult; Aging; Animals; Biological Availability; Biotransformation; Bone Marrow Transplan | 1996 |
Cancer chemotherapy in the elderly.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anthraquinones; Antineoplastic Agents; Breast Neo | 1998 |
Hemopoietic stem cell heterogeneity: use of cell cycle-specific drugs to look for age-associated alterations.
Topics: Aging; Animals; Antineoplastic Agents; Bone Marrow; Bone Marrow Transplantation; Busulfan; Cell Cycl | 1979 |
Other Studies
24 other studies available for busulfan and Aging
| Article | Year |
|---|---|
Busulfan Suppresses Autophagy in Mouse Spermatogonial Progenitor Cells via mTOR of AKT and p53 Signaling Pathways.
Topics: Aging; Animals; Autophagy; Busulfan; Cell Survival; Cells, Cultured; Gene Expression Profiling; Male | 2020 |
Expression patterns and changes of the LCN2 gene in the testes of induced cryptorchidism and busulfan-treated mice.
Topics: Aging; Animals; Busulfan; Cryptorchidism; Gene Expression; In Situ Hybridization; Infertility, Male; | 2017 |
Accelerated ovarian aging in mice by treatment of busulfan and cyclophosphamide.
Topics: Aging; Animals; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; B | 2013 |
Reduced-intensity conditioning hematopoietic stem cell transplantation in patients over 60 years: hematologic malignancy outcomes are not impaired in advanced age.
Topics: Age Factors; Aged; Aging; Blood Donors; Busulfan; Disease-Free Survival; Female; Graft vs Host Disea | 2010 |
Reduced intensity conditioning regimen with fludarabine, busulfan, and low-dose TBI (Flu-BU2-TBI): clinical efficacy in high-risk patients.
Topics: Adult; Aged; Aging; Busulfan; Hematopoietic Stem Cell Transplantation; Humans; Middle Aged; Myeloabl | 2010 |
A new and fast technique to generate offspring after germ cells transplantation in adult fish: the Nile tilapia (Oreochromis niloticus) model.
Topics: Aging; Animals; Animals, Genetically Modified; Breeding; Busulfan; Cichlids; Cryopreservation; Male; | 2010 |
FURTHER OBSERVATIONS ON LATE SOMATIC EFFECTS OF RADIOMIMETIC CHEMICALS AND X-RAYS IN MICE.
Topics: Aging; Busulfan; Cataract; Female; Humans; Leukemia; Leukemia, Myeloid; Longevity; Lung Neoplasms; L | 1965 |
Stem cells: more like a man.
Topics: Aging; Animals; Biomarkers; Busulfan; Cell Count; Cell Differentiation; Cell Division; Female; Male; | 2004 |
Germline stem cells and follicular renewal in the postnatal mammalian ovary.
Topics: Aging; Animals; Biomarkers; Busulfan; Cell Count; Cell Differentiation; Cell Division; Female; Gene | 2004 |
Germline stem cells and follicular renewal in the postnatal mammalian ovary.
Topics: Aging; Animals; Biomarkers; Busulfan; Cell Count; Cell Differentiation; Cell Division; Female; Gene | 2004 |
Germline stem cells and follicular renewal in the postnatal mammalian ovary.
Topics: Aging; Animals; Biomarkers; Busulfan; Cell Count; Cell Differentiation; Cell Division; Female; Gene | 2004 |
Germline stem cells and follicular renewal in the postnatal mammalian ovary.
Topics: Aging; Animals; Biomarkers; Busulfan; Cell Count; Cell Differentiation; Cell Division; Female; Gene | 2004 |
Cataracts among cancer survivors.
Topics: Adrenal Cortex Hormones; Adult; Aging; Bone Marrow Transplantation; Breast Neoplasms; Busulfan; Cata | 2005 |
Aging does not affect spermatogenic recovery after experimentally induced injury in mice.
Topics: Aging; Alkylating Agents; Animals; Busulfan; Cell Nucleus; Cold Temperature; Male; Mice; Mice, Inbre | 2007 |
Generation of functional multipotent adult stem cells from GPR125+ germline progenitors.
Topics: Adult Stem Cells; Aging; Animals; Blood Vessels; Busulfan; Cell Differentiation; Cell Line; Gene Exp | 2007 |
Additional observations on the effects of busulfan on cataract formation, duration of anesthesia, and reproduction in rats.
Topics: Aging; Anesthesia; Animals; Animals, Newborn; Busulfan; Cataract; Diet; Female; Male; Pregnancy; Rat | 1967 |
Increased cancer risk in canine radiation chimeras.
Topics: Aging; Animals; Bone Marrow Transplantation; Busulfan; Central Nervous System Diseases; Cyclophospha | 1980 |
The capacity of testicular cells of the postnatal rat to reorganize into histotypic structures.
Topics: Aging; Animals; Busulfan; Cells, Cultured; Female; Male; Morphogenesis; Ovary; Rats; Testis | 1981 |
Age-dependent tetrahydrothiophenium ion formation in young children and adults receiving high-dose busulfan.
Topics: Absorption; Administration, Oral; Adolescent; Adult; Aging; Antineoplastic Agents, Alkylating; Area | 1997 |
Constitutive expression of interleukin-1alpha messenger ribonucleic acid in rat Sertoli cells is dependent upon interaction with germ cells.
Topics: Aging; Animals; Busulfan; Cells, Cultured; Gene Expression Regulation, Developmental; Interleukin-1; | 1999 |
Pharmacokinetics of high-dose busulphan in relation to age and chronopharmacology.
Topics: Adolescent; Adult; Aging; Busulfan; Child; Child, Preschool; Chronobiology Phenomena; Circadian Rhyt | 1991 |
Effect of age and busulphan treatment on the hsp70 gene-related transcript level in rat testes.
Topics: Aging; Animals; Blotting, Northern; Busulfan; Heat-Shock Proteins; Male; Rats; Rats, Inbred Strains; | 1989 |
Sequential studies of bone marrow haemopoietic progenitors (CFU-GEM, BFU-E, CFU-E, CFU-GM) following busulfan treatment in Balb/c mice.
Topics: Aging; Animals; Bone Marrow; Bone Marrow Cells; Busulfan; Cells, Cultured; Hematocrit; Hematopoietic | 1986 |
The endocrine function of rat gonads with reduced number of germ cells following busulphan treatment.
Topics: Aging; Animals; Body Weight; Busulfan; Chorionic Gonadotropin; Estradiol; Female; Fetus; Male; Organ | 1986 |
The effect of prenatal treatment with busulfan on in vitro androgen production by testes from rats of various ages.
Topics: Aging; Androgens; Animals; Body Weight; Busulfan; Female; Luteinizing Hormone; Male; Maternal-Fetal | 1985 |
Neuroendocrine reactions and the radiation-induced variations in rat intestinal alkaline ribonuclease levels.
Topics: Adrenocorticotropic Hormone; Aging; Alkalies; Animals; Busulfan; Chlorambucil; Endocrine Glands; Fem | 1968 |
Errors and artefacts in serum folic-acid assays. Effects of age, food, drugs and radiation.
Topics: Aging; Anti-Bacterial Agents; Biological Assay; Blood Chemical Analysis; Busulfan; Chloroquine; Diet | 1965 |