Page last updated: 2024-10-24

busulfan and Aging

busulfan has been researched along with Aging in 27 studies

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
" In adults, pharmacodynamic studies have shown a positive correlation between high-systemic exposure of the drug and venocclusive disease (VOD)."2.39Aspects concerning busulfan pharmacokinetics and bioavailability. ( Ehrsson, H; Hassan, M; Ljungman, P, 1996)
"Cataracts affect a minority of long-term cancer survivors, but those who reported them were more likely to report that cancer had had a lasting effect on their overall health."1.33Cataracts among cancer survivors. ( Beck, M; Stava, C; Vassilopoulou-Sellin, R, 2005)
" The elimination half-life for the last dose in young children was shorter (2."1.28Pharmacokinetics of high-dose busulphan in relation to age and chronopharmacology. ( Aschan, J; Bekassy, AN; Ehrsson, H; Hassan, M; Ljungman, P; Lönnerholm, G; Oberg, G; Smedmyr, B; Taube, A; Wallin, I, 1991)

Research

Studies (27)

TimeframeStudies, this research(%)All Research%
pre-199011 (40.74)18.7374
1990's5 (18.52)18.2507
2000's5 (18.52)29.6817
2010's5 (18.52)24.3611
2020's1 (3.70)2.80

Authors

AuthorsStudies
Wei, R1
Zhang, X1
Cai, Y1
Liu, H1
Wang, B1
Zhao, X1
Zou, K1
Kang, Z1
Qiao, N1
Tan, Z1
Tang, Z1
Li, Y1
Jiang, Y1
Zhao, J1
Qi, HJ1
Li, XL1
Zhang, SR1
Song, DW1
Yu, CY1
Gao, JG1
Koreth, J1
Aldridge, J1
Kim, HT1
Alyea, EP1
Cutler, C1
Armand, P1
Ritz, J1
Antin, JH1
Soiffer, RJ1
Ho, VT1
Takahata, M1
Hashino, S1
Okada, K1
Onozawa, M1
Kahata, K1
Sugita, J1
Shigematsu, A1
Kondo, T1
Yamamoto, S1
Endo, T1
Nishio, M1
Ito, YM1
Tanaka, J1
Koike, T1
Asaka, M1
Imamura, M1
Lacerda, SM1
Batlouni, SR1
Costa, GM1
Segatelli, TM1
Quirino, BR1
Queiroz, BM1
Kalapothakis, E1
França, LR1
CONKLIN, JW1
UPTON, AC1
CHRISTENBERRY, KW1
Spradling, AC1
Johnson, J1
Canning, J1
Kaneko, T1
Pru, JK1
Tilly, JL1
Stava, C1
Beck, M1
Vassilopoulou-Sellin, R1
Ehmcke, J1
Joshi, B1
Hergenrother, SD1
Schlatt, S1
Seandel, M1
James, D1
Shmelkov, SV1
Falciatori, I1
Kim, J1
Chavala, S1
Scherr, DS1
Zhang, F1
Torres, R1
Gale, NW1
Yancopoulos, GD1
Murphy, A1
Valenzuela, DM1
Hobbs, RM1
Pandolfi, PP1
Rafii, S1
Light, AE1
Deeg, HJ1
Storb, R1
Prentice, R1
Fritz, TE1
Weiden, PL1
Sale, GE1
Graham, TC1
Thomas, ED1
Zenzes, MT1
Engel, W1
Hassan, M2
Ehrsson, H2
Ljungman, P2
Gibbs, JP1
Murray, G1
Risler, L1
Chien, JY1
Dev, R1
Slattery, JT1
Sekine, I1
Fukuda, H1
Kunitoh, H1
Saijo, N1
Jonsson, CK1
Zetterström, RH1
Holst, M1
Parvinen, M1
Söder, O1
Popp, DM1
Popp, RA1
Oberg, G1
Bekassy, AN1
Aschan, J1
Lönnerholm, G1
Smedmyr, B1
Taube, A1
Wallin, I1
Krawczyk, Z1
Szymik, N1
Reynolds, M1
McCann, SR1
Kasuga, F1
Takahashi, M1
Jansz, GF1
Pomerantz, DK1
Gresham, PA1
Pover, WF1
Reizenstein, P1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
CD133+ Autologue Transplantation to Promote Ovarian Follicles Development in Women With Poor Ovarian Reserve.[NCT01966536]0 participants (Actual)Interventional2013-11-30Withdrawn (stopped due to Due to fundamental changes in procedures design no patients have been enrolled)
Antioxidants vs.Ovarian Bio-stimulation Therapy to Rescue the Ovarian Reserve[NCT03621683]78 participants (Actual)Interventional2016-01-06Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

3 reviews available for busulfan and Aging

ArticleYear
Aspects concerning busulfan pharmacokinetics and bioavailability.
    Leukemia & lymphoma, 1996, Volume: 22, Issue:5-6

    Topics: Adolescent; Adult; Aging; Animals; Biological Availability; Biotransformation; Bone Marrow Transplan

1996
Cancer chemotherapy in the elderly.
    Japanese journal of clinical oncology, 1998, Volume: 28, Issue:8

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anthraquinones; Antineoplastic Agents; Breast Neo

1998
Hemopoietic stem cell heterogeneity: use of cell cycle-specific drugs to look for age-associated alterations.
    Mechanisms of ageing and development, 1979, Volume: 9, Issue:5-6

    Topics: Aging; Animals; Antineoplastic Agents; Bone Marrow; Bone Marrow Transplantation; Busulfan; Cell Cycl

1979

Other Studies

24 other studies available for busulfan and Aging

ArticleYear
Busulfan Suppresses Autophagy in Mouse Spermatogonial Progenitor Cells via mTOR of AKT and p53 Signaling Pathways.
    Stem cell reviews and reports, 2020, Volume: 16, Issue:6

    Topics: Aging; Animals; Autophagy; Busulfan; Cell Survival; Cells, Cultured; Gene Expression Profiling; Male

2020
Expression patterns and changes of the LCN2 gene in the testes of induced cryptorchidism and busulfan-treated mice.
    Systems biology in reproductive medicine, 2017, Volume: 63, Issue:6

    Topics: Aging; Animals; Busulfan; Cryptorchidism; Gene Expression; In Situ Hybridization; Infertility, Male;

2017
Accelerated ovarian aging in mice by treatment of busulfan and cyclophosphamide.
    Journal of Zhejiang University. Science. B, 2013, Volume: 14, Issue:4

    Topics: Aging; Animals; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; B

2013
Reduced-intensity conditioning hematopoietic stem cell transplantation in patients over 60 years: hematologic malignancy outcomes are not impaired in advanced age.
    Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2010, Volume: 16, Issue:6

    Topics: Age Factors; Aged; Aging; Blood Donors; Busulfan; Disease-Free Survival; Female; Graft vs Host Disea

2010
Reduced intensity conditioning regimen with fludarabine, busulfan, and low-dose TBI (Flu-BU2-TBI): clinical efficacy in high-risk patients.
    American journal of hematology, 2010, Volume: 85, Issue:4

    Topics: Adult; Aged; Aging; Busulfan; Hematopoietic Stem Cell Transplantation; Humans; Middle Aged; Myeloabl

2010
A new and fast technique to generate offspring after germ cells transplantation in adult fish: the Nile tilapia (Oreochromis niloticus) model.
    PloS one, 2010, May-20, Volume: 5, Issue:5

    Topics: Aging; Animals; Animals, Genetically Modified; Breeding; Busulfan; Cichlids; Cryopreservation; Male;

2010
FURTHER OBSERVATIONS ON LATE SOMATIC EFFECTS OF RADIOMIMETIC CHEMICALS AND X-RAYS IN MICE.
    Cancer research, 1965, Volume: 25

    Topics: Aging; Busulfan; Cataract; Female; Humans; Leukemia; Leukemia, Myeloid; Longevity; Lung Neoplasms; L

1965
Stem cells: more like a man.
    Nature, 2004, Mar-11, Volume: 428, Issue:6979

    Topics: Aging; Animals; Biomarkers; Busulfan; Cell Count; Cell Differentiation; Cell Division; Female; Male;

2004
Germline stem cells and follicular renewal in the postnatal mammalian ovary.
    Nature, 2004, Mar-11, Volume: 428, Issue:6979

    Topics: Aging; Animals; Biomarkers; Busulfan; Cell Count; Cell Differentiation; Cell Division; Female; Gene

2004
Germline stem cells and follicular renewal in the postnatal mammalian ovary.
    Nature, 2004, Mar-11, Volume: 428, Issue:6979

    Topics: Aging; Animals; Biomarkers; Busulfan; Cell Count; Cell Differentiation; Cell Division; Female; Gene

2004
Germline stem cells and follicular renewal in the postnatal mammalian ovary.
    Nature, 2004, Mar-11, Volume: 428, Issue:6979

    Topics: Aging; Animals; Biomarkers; Busulfan; Cell Count; Cell Differentiation; Cell Division; Female; Gene

2004
Germline stem cells and follicular renewal in the postnatal mammalian ovary.
    Nature, 2004, Mar-11, Volume: 428, Issue:6979

    Topics: Aging; Animals; Biomarkers; Busulfan; Cell Count; Cell Differentiation; Cell Division; Female; Gene

2004
Cataracts among cancer survivors.
    American journal of clinical oncology, 2005, Volume: 28, Issue:6

    Topics: Adrenal Cortex Hormones; Adult; Aging; Bone Marrow Transplantation; Breast Neoplasms; Busulfan; Cata

2005
Aging does not affect spermatogenic recovery after experimentally induced injury in mice.
    Reproduction (Cambridge, England), 2007, Volume: 133, Issue:1

    Topics: Aging; Alkylating Agents; Animals; Busulfan; Cell Nucleus; Cold Temperature; Male; Mice; Mice, Inbre

2007
Generation of functional multipotent adult stem cells from GPR125+ germline progenitors.
    Nature, 2007, Sep-20, Volume: 449, Issue:7160

    Topics: Adult Stem Cells; Aging; Animals; Blood Vessels; Busulfan; Cell Differentiation; Cell Line; Gene Exp

2007
Additional observations on the effects of busulfan on cataract formation, duration of anesthesia, and reproduction in rats.
    Toxicology and applied pharmacology, 1967, Volume: 10, Issue:3

    Topics: Aging; Anesthesia; Animals; Animals, Newborn; Busulfan; Cataract; Diet; Female; Male; Pregnancy; Rat

1967
Increased cancer risk in canine radiation chimeras.
    Blood, 1980, Volume: 55, Issue:2

    Topics: Aging; Animals; Bone Marrow Transplantation; Busulfan; Central Nervous System Diseases; Cyclophospha

1980
The capacity of testicular cells of the postnatal rat to reorganize into histotypic structures.
    Differentiation; research in biological diversity, 1981, Volume: 20, Issue:2

    Topics: Aging; Animals; Busulfan; Cells, Cultured; Female; Male; Morphogenesis; Ovary; Rats; Testis

1981
Age-dependent tetrahydrothiophenium ion formation in young children and adults receiving high-dose busulfan.
    Cancer research, 1997, Dec-15, Volume: 57, Issue:24

    Topics: Absorption; Administration, Oral; Adolescent; Adult; Aging; Antineoplastic Agents, Alkylating; Area

1997
Constitutive expression of interleukin-1alpha messenger ribonucleic acid in rat Sertoli cells is dependent upon interaction with germ cells.
    Endocrinology, 1999, Volume: 140, Issue:8

    Topics: Aging; Animals; Busulfan; Cells, Cultured; Gene Expression Regulation, Developmental; Interleukin-1;

1999
Pharmacokinetics of high-dose busulphan in relation to age and chronopharmacology.
    Cancer chemotherapy and pharmacology, 1991, Volume: 28, Issue:2

    Topics: Adolescent; Adult; Aging; Busulfan; Child; Child, Preschool; Chronobiology Phenomena; Circadian Rhyt

1991
Effect of age and busulphan treatment on the hsp70 gene-related transcript level in rat testes.
    International journal of andrology, 1989, Volume: 12, Issue:1

    Topics: Aging; Animals; Blotting, Northern; Busulfan; Heat-Shock Proteins; Male; Rats; Rats, Inbred Strains;

1989
Sequential studies of bone marrow haemopoietic progenitors (CFU-GEM, BFU-E, CFU-E, CFU-GM) following busulfan treatment in Balb/c mice.
    Journal of immunopharmacology, 1986, Volume: 8, Issue:1

    Topics: Aging; Animals; Bone Marrow; Bone Marrow Cells; Busulfan; Cells, Cultured; Hematocrit; Hematopoietic

1986
The endocrine function of rat gonads with reduced number of germ cells following busulphan treatment.
    Endocrinologia japonica, 1986, Volume: 33, Issue:1

    Topics: Aging; Animals; Body Weight; Busulfan; Chorionic Gonadotropin; Estradiol; Female; Fetus; Male; Organ

1986
The effect of prenatal treatment with busulfan on in vitro androgen production by testes from rats of various ages.
    Canadian journal of physiology and pharmacology, 1985, Volume: 63, Issue:9

    Topics: Aging; Androgens; Animals; Body Weight; Busulfan; Female; Luteinizing Hormone; Male; Maternal-Fetal

1985
Neuroendocrine reactions and the radiation-induced variations in rat intestinal alkaline ribonuclease levels.
    Radiation research, 1968, Volume: 34, Issue:2

    Topics: Adrenocorticotropic Hormone; Aging; Alkalies; Animals; Busulfan; Chlorambucil; Endocrine Glands; Fem

1968
Errors and artefacts in serum folic-acid assays. Effects of age, food, drugs and radiation.
    Acta medica Scandinavica, 1965, Volume: 178, Issue:2

    Topics: Aging; Anti-Bacterial Agents; Biological Assay; Blood Chemical Analysis; Busulfan; Chloroquine; Diet

1965