buspirone and Autism
buspirone has been researched along with Autism in 10 studies
Buspirone: An anxiolytic agent and serotonin receptor agonist belonging to the azaspirodecanedione class of compounds. Its structure is unrelated to those of the BENZODIAZAPINES, but it has an efficacy comparable to DIAZEPAM.
buspirone : An azaspiro compound that is 8-azaspiro[4.5]decane-7,9-dione substituted at the nitrogen atom by a 4-(piperazin-1-yl)butyl group which in turn is substituted by a pyrimidin-2-yl group at the N(4) position.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "This clinical trial supports that low dose buspirone plus risperidone is more effective than risperidone plus placebo for treating irritability in individuals with autism." | 9.20 | A randomized double-blind placebo-controlled clinical trial of adjuvant buspirone for irritability in autism. ( Ayoobzadehshirazi, A; Ghanizadeh, A, 2015) |
| "To describe a case of an intellectually disabled patient who was diagnosed with autistic disorder (AD) and responded positively to buspirone, demonstrated by a reduction in target behaviors of self-injury, property destruction, and physical aggression." | 7.74 | Buspirone for autistic disorder in a woman with an intellectual disability. ( Brahm, NC; Brown, RC; Fast, GA, 2008) |
| "This clinical trial supports that low dose buspirone plus risperidone is more effective than risperidone plus placebo for treating irritability in individuals with autism." | 5.20 | A randomized double-blind placebo-controlled clinical trial of adjuvant buspirone for irritability in autism. ( Ayoobzadehshirazi, A; Ghanizadeh, A, 2015) |
| " To pursue an antiserotonergic treatment rationale for autistic disorder, an open-blind 4-week trial comparing buspirone to fenfluramine or methylphenidate was conducted." | 5.06 | Clinical effect of buspirone in autistic children. ( August, GJ; Garfinkel, BD; Realmuto, GM, 1989) |
| "To describe a case of an intellectually disabled patient who was diagnosed with autistic disorder (AD) and responded positively to buspirone, demonstrated by a reduction in target behaviors of self-injury, property destruction, and physical aggression." | 3.74 | Buspirone for autistic disorder in a woman with an intellectual disability. ( Brahm, NC; Brown, RC; Fast, GA, 2008) |
| " The peak concentration of buspirone averaged 1141 +/- 748 pg/mL with a time to maximum concentration of 0." | 2.72 | Pharmacokinetics of buspirone in autistic children. ( Aranda, JV; Chehab, J; Chugani, DC; Chugani, HT; Edwards, DJ; Malian, M, 2006) |
Research
Studies (10)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (10.00) | 18.7374 |
| 1990's | 2 (20.00) | 18.2507 |
| 2000's | 4 (40.00) | 29.6817 |
| 2010's | 1 (10.00) | 24.3611 |
| 2020's | 2 (20.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Gupta, M | 1 |
| Gupta, N | 1 |
| Moll, J | 1 |
| Ramar, D | 1 |
| Higuchi, Y | 1 |
| Tada, T | 1 |
| Nakachi, T | 1 |
| Arakawa, H | 1 |
| Ghanizadeh, A | 1 |
| Ayoobzadehshirazi, A | 1 |
| Edwards, DJ | 1 |
| Chugani, DC | 1 |
| Chugani, HT | 1 |
| Chehab, J | 1 |
| Malian, M | 1 |
| Aranda, JV | 1 |
| Brahm, NC | 1 |
| Fast, GA | 1 |
| Brown, RC | 1 |
| Hillbrand, M | 1 |
| Scott, K | 1 |
| Frischauf, E | 1 |
| Hunsinger, DM | 1 |
| Nguyen, T | 1 |
| Zebraski, SE | 1 |
| Raffa, RB | 1 |
| Hollander, E | 1 |
| Dolgoff-Kaspar, R | 1 |
| Cartwright, C | 1 |
| Rawitt, R | 1 |
| Novotny, S | 1 |
| Realmuto, GM | 1 |
| August, GJ | 1 |
| Garfinkel, BD | 1 |
Reviews
1 review available for buspirone and Autism
| Article | Year |
|---|---|
Is there a basis for novel pharmacotherapy of autism?
Topics: Amino Acid Sequence; Animals; Antipsychotic Agents; Autistic Disorder; Buspirone; Dietary Supplement | 2000 |
Trials
4 trials available for buspirone and Autism
| Article | Year |
|---|---|
A randomized double-blind placebo-controlled clinical trial of adjuvant buspirone for irritability in autism.
Topics: Ambulatory Care; Autistic Disorder; Buspirone; Child; Double-Blind Method; Drug Therapy, Combination | 2015 |
Pharmacokinetics of buspirone in autistic children.
Topics: Anti-Anxiety Agents; Autistic Disorder; Buspirone; Child; Child, Preschool; Female; Humans; Male; Se | 2006 |
An open trial of divalproex sodium in autism spectrum disorders.
Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Antipsychotic Agents; Asperger Syndrome; Autistic D | 2001 |
Clinical effect of buspirone in autistic children.
Topics: Autistic Disorder; Buspirone; Child; Female; Fenfluramine; Humans; Male; Methylphenidate | 1989 |
Other Studies
5 other studies available for buspirone and Autism
| Article | Year |
|---|---|
Buspirone for Comorbid Anxiety in Autism.
Topics: Anti-Anxiety Agents; Anxiety; Anxiety Disorders; Autistic Disorder; Buspirone; Comorbidity; Double-B | 2023 |
Serotonergic circuit dysregulation underlying autism-related phenotypes in BTBR mouse model of autism.
Topics: Animals; Autism Spectrum Disorder; Autistic Disorder; Buspirone; Disease Models, Animal; Female; Hum | 2023 |
Buspirone for autistic disorder in a woman with an intellectual disability.
Topics: Adult; Aggression; Anti-Anxiety Agents; Antipsychotic Agents; Autistic Disorder; Buspirone; Epilepsy | 2008 |
The use of buspirone with aggressive behavior.
Topics: Adult; Aggression; Anti-Anxiety Agents; Autistic Disorder; Buspirone; Hospitalization; Hospitals, Ps | 1995 |
Drug therapy in autism.
Topics: Anti-Anxiety Agents; Antipsychotic Agents; Autistic Disorder; Buspirone; Child; Depression; Drug The | 1997 |