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bromhexine and Cough

bromhexine has been researched along with Cough in 19 studies

Bromhexine: A mucolytic agent used in the treatment of respiratory disorders associated with viscid or excessive mucus. (From Martindale, The Extra Pharmacopoeia, 30th ed, p744)
bromhexine : A substituted aniline that is 2,4-dibromoaniline which is substituted at position 6 by a [cyclohexyl(methyl)amino]methyl group. It is used (as the monohydrochloride salt) as a mucolytic for the treatment of respiratory disorders associated with productive cough (i.e. a cough characterised by the production of sputum).

Cough: A sudden, audible expulsion of air from the lungs through a partially closed glottis, preceded by inhalation. It is a protective response that serves to clear the trachea, bronchi, and/or lungs of irritants and secretions, or to prevent aspiration of foreign materials into the lungs.

Research Excerpts

ExcerptRelevanceReference
"To evaluate the efficacy and safety of a combination drug containing ambroxol, guaifenesin, and levosalbutamol, oral solution, versus Ascoril Expectorant, syrup (combination of bromhexine, guaifenesin, and salbutamol) in the treatment of productive cough in adult patients with acute bronchitis."9.69[Evaluation of the efficacy and safety of a combination drug containing ambroxol, guaifenesin, and levosalbutamol versus a fixed-dose combination of bromhexine/guaifenesin/salbutamol in the treatment of productive cough in adult patients with acute bronch ( Esaulova, NA; Leshchenko, IV; Viktorova, IA; Zaitsev, AA, 2023)
"Twenty-three patients with exacerbations of chronic bronchitis were divided in two groups in a randomized fashion receiving either amoxicillin 1500 mg/d (n = 13) or amoxicillin 1500 mg/d associated with the mucolytic drug ambroxol 90 mg/d (n = 10)."9.06Ambroxol plus amoxicillin in the treatment of exacerbations of chronic bronchitis. ( Corazza, C; Fernández, M; Guerreiro, RB; Peralta, J; Poderoso, JJ; Wiemeyer, JC, 1987)
"Controlled clinical research has been carried out on the activity and tolerance of a new active principle, guacetisal (Broncaspin) obtained from the esterification of acetylsalicylic acid with guaiacol, in the treatment of chronic bronchitis."9.05[Controlled clinical study of the treatment of chronic bronchitis with guacetisal]. ( Caltagirone, S; Crimi, N; Cusmano, F; Di Maria, GU; Palermo, F; Vagliasindi, M, 1981)
"To evaluate the efficacy and safety of a combination drug containing ambroxol, guaifenesin, and levosalbutamol, oral solution, versus Ascoril Expectorant, syrup (combination of bromhexine, guaifenesin, and salbutamol) in the treatment of productive cough in adult patients with acute bronchitis."5.69[Evaluation of the efficacy and safety of a combination drug containing ambroxol, guaifenesin, and levosalbutamol versus a fixed-dose combination of bromhexine/guaifenesin/salbutamol in the treatment of productive cough in adult patients with acute bronch ( Esaulova, NA; Leshchenko, IV; Viktorova, IA; Zaitsev, AA, 2023)
"03 mg/ml eleutherosides B and E), bromhexine hydrochloride (24 mg/30 ml/day) and PL on cough and blood markers."5.20Antitussive effect of a fixed combination of Justicia adhatoda, Echinacea purpurea and Eleutherococcus senticosus extracts in patients with acute upper respiratory tract infection: A comparative, randomized, double-blind, placebo-controlled study. ( Barth, A; Hovhannisyan, A; Jamalyan, K; Narimanyan, M, 2015)
"Twenty-three patients with exacerbations of chronic bronchitis were divided in two groups in a randomized fashion receiving either amoxicillin 1500 mg/d (n = 13) or amoxicillin 1500 mg/d associated with the mucolytic drug ambroxol 90 mg/d (n = 10)."5.06Ambroxol plus amoxicillin in the treatment of exacerbations of chronic bronchitis. ( Corazza, C; Fernández, M; Guerreiro, RB; Peralta, J; Poderoso, JJ; Wiemeyer, JC, 1987)
"Controlled clinical research has been carried out on the activity and tolerance of a new active principle, guacetisal (Broncaspin) obtained from the esterification of acetylsalicylic acid with guaiacol, in the treatment of chronic bronchitis."5.05[Controlled clinical study of the treatment of chronic bronchitis with guacetisal]. ( Caltagirone, S; Crimi, N; Cusmano, F; Di Maria, GU; Palermo, F; Vagliasindi, M, 1981)
"Results."2.79[Therapeutic modalities for the management of cough associated with acute respiratory viral infection, effective in an otolaryngologist's practice]. ( Korostelev, SA; Mitiuk, AM; Ovchinnikov, AI; Paniakina, MA, 2014)
" Ascoril expectorant caused no adverse reactions and was well tolerated by the patients."2.78[Results of international multicentre non-interventional clinical study of the effectiveness and safety of ascoril expectorant for the treatment of cough in Kazakhstan and Uzbekistan]. ( Abuova, GT; An, ÉA; Ermekbaeva, BA; Guliaev, AE; Nurgozhin, TS; Zhaugasheva, SK, 2013)
" No serious adverse events were noted."1.31Efficacy and safety of Ascoril in the management of cough--National Study Group report. ( Ainapure, SS; Desai, A; Korde, K, 2001)

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-199011 (57.89)18.7374
1990's1 (5.26)18.2507
2000's2 (10.53)29.6817
2010's4 (21.05)24.3611
2020's1 (5.26)2.80

Authors

AuthorsStudies
Zaitsev, AA1
Leshchenko, IV1
Esaulova, NA1
Viktorova, IA1
Nurgozhin, TS1
Guliaev, AE1
Ermekbaeva, BA1
Zhaugasheva, SK1
Abuova, GT1
An, ÉA1
Ovchinnikov, AI1
Paniakina, MA1
Korostelev, SA1
Mitiuk, AM1
Barth, A1
Hovhannisyan, A1
Jamalyan, K1
Narimanyan, M1
Prabhu Shankar, S1
Chandrashekharan, S1
Bolmall, CS1
Baliga, V1
Nagy, G1
Berni, M1
Collina, A1
Zavattini, G1
Richardson, PS1
Caltagirone, S1
Vagliasindi, M1
Palermo, F1
Di Maria, GU1
Crimi, N1
Cusmano, F1
Zanierato, G1
Ranghino, E1
Negri, L1
Morandini, GC1
Camner, P2
Mossberg, B1
Philipson, K1
Strandberg, K1
Jayaram, S1
Desai, A2
Ainapure, SS1
Korde, K1
Alesina, R1
Caliandro, L1
Cerveri, I1
Scala, C1
von Harnack, GA1
Bury, T1
Corhay, JL1
Radermecker, MF1
Germouty, J1
Jirou-Najou, JL1
Peralta, J1
Poderoso, JJ1
Corazza, C1
Fernández, M1
Guerreiro, RB1
Wiemeyer, JC1

Reviews

1 review available for bromhexine and Cough

ArticleYear
Theory and practice of the use of expectorants reviewed from clinical aspects.
    Therapia Hungarica (English edition), 1984, Volume: 32, Issue:1

    Topics: Acetylcysteine; Bromhexine; Carbocysteine; Cilia; Cough; Expectorants; Guaiacol; Humans; Mucus; Poly

1984

Trials

13 trials available for bromhexine and Cough

ArticleYear
[Evaluation of the efficacy and safety of a combination drug containing ambroxol, guaifenesin, and levosalbutamol versus a fixed-dose combination of bromhexine/guaifenesin/salbutamol in the treatment of productive cough in adult patients with acute bronch
    Terapevticheskii arkhiv, 2023, Apr-26, Volume: 95, Issue:3

    Topics: Acute Disease; Adult; Albuterol; Ambroxol; Bromhexine; Bronchitis; Cough; Drug Combinations; Expecto

2023
[Results of international multicentre non-interventional clinical study of the effectiveness and safety of ascoril expectorant for the treatment of cough in Kazakhstan and Uzbekistan].
    Klinicheskaia meditsina, 2013, Volume: 91, Issue:6

    Topics: Adolescent; Adrenergic beta-2 Receptor Agonists; Adult; Aged; Albuterol; Bromhexine; Child, Preschoo

2013
[Therapeutic modalities for the management of cough associated with acute respiratory viral infection, effective in an otolaryngologist's practice].
    Vestnik otorinolaringologii, 2014, Issue:2

    Topics: Acute Disease; Adult; Albuterol; Ambroxol; Bromhexine; Bronchodilator Agents; Cough; Drug Combinatio

2014
Antitussive effect of a fixed combination of Justicia adhatoda, Echinacea purpurea and Eleutherococcus senticosus extracts in patients with acute upper respiratory tract infection: A comparative, randomized, double-blind, placebo-controlled study.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2015, Dec-01, Volume: 22, Issue:13

    Topics: Adult; Antitussive Agents; Bromhexine; Common Cold; Cough; Double-Blind Method; Echinacea; Eleuthero

2015
Efficacy, safety and tolerability of salbutamol + guaiphenesin + bromhexine (Ascoril) expectorant versus expectorants containing salbutamol and either guaiphenesin or bromhexine in productive cough: a randomised controlled comparative study.
    Journal of the Indian Medical Association, 2010, Volume: 108, Issue:5

    Topics: Adolescent; Adult; Aged; Albuterol; Bromhexine; Cough; Double-Blind Method; Drug Combinations; Expec

2010
[Controlled clinical study of the treatment of chronic bronchitis with guacetisal].
    Minerva medica, 1981, Feb-28, Volume: 72, Issue:7

    Topics: Adult; Aged; Aspirin; Bromhexine; Bronchitis; Chronic Disease; Clinical Trials as Topic; Cough; Fema

1981
[Treatment of bronchial inflammatory disorders with guacetisal].
    Minerva medica, 1981, Feb-28, Volume: 72, Issue:7

    Topics: Acute Disease; Aspirin; Bromhexine; Bronchitis; Carbonates; Chronic Disease; Clinical Trials as Topi

1981
Studies on the removal of inhaled particles from the lungs by voluntary coughing.
    Chest, 1981, Volume: 80, Issue:6 Suppl

    Topics: Aerosols; Bromhexine; Cilia; Clinical Trials as Topic; Cough; Double-Blind Method; Humans; Lung; Lun

1981
Clearance by voluntary coughing and its relationship to subjective assessment and effect of intravenous bromhexine.
    European journal of respiratory diseases, 1981, Volume: 62, Issue:3

    Topics: Adult; Aged; Airway Obstruction; Bromhexine; Chronic Disease; Cough; Female; Humans; Male; Microsphe

1981
Efficacy and safety of Ascoril expectorant and other cough formula in the treatment of cough management in paediatric and adult patients--a randomised double-blind comparative trial.
    Journal of the Indian Medical Association, 2000, Volume: 98, Issue:2

    Topics: Adolescent; Adult; Albuterol; Ammonium Chloride; Bromhexine; Child; Child, Preschool; Citrates; Coug

2000
[Clinical use of the combination prenoxidiazine-S-carboxy-methyl-cysteine].
    Giornale di clinica medica, 1979, Volume: 60, Issue:2

    Topics: Adult; Aged; Antitussive Agents; Bromhexine; Bronchial Diseases; Bronchial Spasm; Carbocysteine; Cli

1979
Clinical efficacy of ambroxol in the treatment of bronchial stasis. Clinical trial in 120 patients at two different doses.
    Respiration; international review of thoracic diseases, 1987, Volume: 51 Suppl 1

    Topics: Adult; Aged; Ambroxol; Bromhexine; Bronchial Diseases; Clinical Trials as Topic; Cough; Dose-Respons

1987
Ambroxol plus amoxicillin in the treatment of exacerbations of chronic bronchitis.
    Arzneimittel-Forschung, 1987, Volume: 37, Issue:8

    Topics: Adult; Aged; Aged, 80 and over; Ambroxol; Amoxicillin; Blood Gas Analysis; Bromhexine; Bronchitis; C

1987

Other Studies

5 other studies available for bromhexine and Cough

ArticleYear
[Ambroxol in bronchopulmonary pathology in children].
    La Clinica terapeutica, 1983, Sep-15, Volume: 106, Issue:5

    Topics: Ambroxol; Bromhexine; Bronchial Diseases; Bronchitis; Carbocysteine; Child; Child, Preschool; Cough;

1983
The principles of drug action on cough and on sputum characteristics.
    European journal of respiratory diseases. Supplement, 1980, Volume: 110

    Topics: Aerosols; Antitussive Agents; Bromhexine; Cough; Disulfides; Glucocorticoids; Humans; Iodides; Mucus

1980
Efficacy and safety of Ascoril in the management of cough--National Study Group report.
    Journal of the Indian Medical Association, 2001, Volume: 99, Issue:2

    Topics: Adolescent; Adult; Aged; Bromhexine; Child; Child, Preschool; Cough; Drug Combinations; Expectorants

2001
[Indication for drug therapy].
    Monatsschrift fur Kinderheilkunde, 1977, Volume: 125, Issue:5

    Topics: Adolescent; Age Factors; Analgesics; Antitussive Agents; Asthma; Bromhexine; Child; Child, Preschool

1977
[Kinetics of mucus].
    Revue medicale de Liege, 1990, Jan-01, Volume: 45, Issue:1

    Topics: Acetylcysteine; Antitussive Agents; Bromhexine; Cough; Expectorants; Humans; Lung Diseases, Obstruct

1990