bromhexine and Cough
bromhexine has been researched along with Cough in 19 studies
Bromhexine: A mucolytic agent used in the treatment of respiratory disorders associated with viscid or excessive mucus. (From Martindale, The Extra Pharmacopoeia, 30th ed, p744)
bromhexine : A substituted aniline that is 2,4-dibromoaniline which is substituted at position 6 by a [cyclohexyl(methyl)amino]methyl group. It is used (as the monohydrochloride salt) as a mucolytic for the treatment of respiratory disorders associated with productive cough (i.e. a cough characterised by the production of sputum).
Cough: A sudden, audible expulsion of air from the lungs through a partially closed glottis, preceded by inhalation. It is a protective response that serves to clear the trachea, bronchi, and/or lungs of irritants and secretions, or to prevent aspiration of foreign materials into the lungs.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate the efficacy and safety of a combination drug containing ambroxol, guaifenesin, and levosalbutamol, oral solution, versus Ascoril Expectorant, syrup (combination of bromhexine, guaifenesin, and salbutamol) in the treatment of productive cough in adult patients with acute bronchitis." | 9.69 | [Evaluation of the efficacy and safety of a combination drug containing ambroxol, guaifenesin, and levosalbutamol versus a fixed-dose combination of bromhexine/guaifenesin/salbutamol in the treatment of productive cough in adult patients with acute bronch ( Esaulova, NA; Leshchenko, IV; Viktorova, IA; Zaitsev, AA, 2023) |
| "Twenty-three patients with exacerbations of chronic bronchitis were divided in two groups in a randomized fashion receiving either amoxicillin 1500 mg/d (n = 13) or amoxicillin 1500 mg/d associated with the mucolytic drug ambroxol 90 mg/d (n = 10)." | 9.06 | Ambroxol plus amoxicillin in the treatment of exacerbations of chronic bronchitis. ( Corazza, C; Fernández, M; Guerreiro, RB; Peralta, J; Poderoso, JJ; Wiemeyer, JC, 1987) |
| "Controlled clinical research has been carried out on the activity and tolerance of a new active principle, guacetisal (Broncaspin) obtained from the esterification of acetylsalicylic acid with guaiacol, in the treatment of chronic bronchitis." | 9.05 | [Controlled clinical study of the treatment of chronic bronchitis with guacetisal]. ( Caltagirone, S; Crimi, N; Cusmano, F; Di Maria, GU; Palermo, F; Vagliasindi, M, 1981) |
| "To evaluate the efficacy and safety of a combination drug containing ambroxol, guaifenesin, and levosalbutamol, oral solution, versus Ascoril Expectorant, syrup (combination of bromhexine, guaifenesin, and salbutamol) in the treatment of productive cough in adult patients with acute bronchitis." | 5.69 | [Evaluation of the efficacy and safety of a combination drug containing ambroxol, guaifenesin, and levosalbutamol versus a fixed-dose combination of bromhexine/guaifenesin/salbutamol in the treatment of productive cough in adult patients with acute bronch ( Esaulova, NA; Leshchenko, IV; Viktorova, IA; Zaitsev, AA, 2023) |
| "03 mg/ml eleutherosides B and E), bromhexine hydrochloride (24 mg/30 ml/day) and PL on cough and blood markers." | 5.20 | Antitussive effect of a fixed combination of Justicia adhatoda, Echinacea purpurea and Eleutherococcus senticosus extracts in patients with acute upper respiratory tract infection: A comparative, randomized, double-blind, placebo-controlled study. ( Barth, A; Hovhannisyan, A; Jamalyan, K; Narimanyan, M, 2015) |
| "Twenty-three patients with exacerbations of chronic bronchitis were divided in two groups in a randomized fashion receiving either amoxicillin 1500 mg/d (n = 13) or amoxicillin 1500 mg/d associated with the mucolytic drug ambroxol 90 mg/d (n = 10)." | 5.06 | Ambroxol plus amoxicillin in the treatment of exacerbations of chronic bronchitis. ( Corazza, C; Fernández, M; Guerreiro, RB; Peralta, J; Poderoso, JJ; Wiemeyer, JC, 1987) |
| "Controlled clinical research has been carried out on the activity and tolerance of a new active principle, guacetisal (Broncaspin) obtained from the esterification of acetylsalicylic acid with guaiacol, in the treatment of chronic bronchitis." | 5.05 | [Controlled clinical study of the treatment of chronic bronchitis with guacetisal]. ( Caltagirone, S; Crimi, N; Cusmano, F; Di Maria, GU; Palermo, F; Vagliasindi, M, 1981) |
| "Results." | 2.79 | [Therapeutic modalities for the management of cough associated with acute respiratory viral infection, effective in an otolaryngologist's practice]. ( Korostelev, SA; Mitiuk, AM; Ovchinnikov, AI; Paniakina, MA, 2014) |
| " Ascoril expectorant caused no adverse reactions and was well tolerated by the patients." | 2.78 | [Results of international multicentre non-interventional clinical study of the effectiveness and safety of ascoril expectorant for the treatment of cough in Kazakhstan and Uzbekistan]. ( Abuova, GT; An, ÉA; Ermekbaeva, BA; Guliaev, AE; Nurgozhin, TS; Zhaugasheva, SK, 2013) |
| " No serious adverse events were noted." | 1.31 | Efficacy and safety of Ascoril in the management of cough--National Study Group report. ( Ainapure, SS; Desai, A; Korde, K, 2001) |
Research
Studies (19)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (57.89) | 18.7374 |
| 1990's | 1 (5.26) | 18.2507 |
| 2000's | 2 (10.53) | 29.6817 |
| 2010's | 4 (21.05) | 24.3611 |
| 2020's | 1 (5.26) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Zaitsev, AA | 1 |
| Leshchenko, IV | 1 |
| Esaulova, NA | 1 |
| Viktorova, IA | 1 |
| Nurgozhin, TS | 1 |
| Guliaev, AE | 1 |
| Ermekbaeva, BA | 1 |
| Zhaugasheva, SK | 1 |
| Abuova, GT | 1 |
| An, ÉA | 1 |
| Ovchinnikov, AI | 1 |
| Paniakina, MA | 1 |
| Korostelev, SA | 1 |
| Mitiuk, AM | 1 |
| Barth, A | 1 |
| Hovhannisyan, A | 1 |
| Jamalyan, K | 1 |
| Narimanyan, M | 1 |
| Prabhu Shankar, S | 1 |
| Chandrashekharan, S | 1 |
| Bolmall, CS | 1 |
| Baliga, V | 1 |
| Nagy, G | 1 |
| Berni, M | 1 |
| Collina, A | 1 |
| Zavattini, G | 1 |
| Richardson, PS | 1 |
| Caltagirone, S | 1 |
| Vagliasindi, M | 1 |
| Palermo, F | 1 |
| Di Maria, GU | 1 |
| Crimi, N | 1 |
| Cusmano, F | 1 |
| Zanierato, G | 1 |
| Ranghino, E | 1 |
| Negri, L | 1 |
| Morandini, GC | 1 |
| Camner, P | 2 |
| Mossberg, B | 1 |
| Philipson, K | 1 |
| Strandberg, K | 1 |
| Jayaram, S | 1 |
| Desai, A | 2 |
| Ainapure, SS | 1 |
| Korde, K | 1 |
| Alesina, R | 1 |
| Caliandro, L | 1 |
| Cerveri, I | 1 |
| Scala, C | 1 |
| von Harnack, GA | 1 |
| Bury, T | 1 |
| Corhay, JL | 1 |
| Radermecker, MF | 1 |
| Germouty, J | 1 |
| Jirou-Najou, JL | 1 |
| Peralta, J | 1 |
| Poderoso, JJ | 1 |
| Corazza, C | 1 |
| Fernández, M | 1 |
| Guerreiro, RB | 1 |
| Wiemeyer, JC | 1 |
Reviews
1 review available for bromhexine and Cough
| Article | Year |
|---|---|
Theory and practice of the use of expectorants reviewed from clinical aspects.
Topics: Acetylcysteine; Bromhexine; Carbocysteine; Cilia; Cough; Expectorants; Guaiacol; Humans; Mucus; Poly | 1984 |
Trials
13 trials available for bromhexine and Cough
| Article | Year |
|---|---|
[Evaluation of the efficacy and safety of a combination drug containing ambroxol, guaifenesin, and levosalbutamol versus a fixed-dose combination of bromhexine/guaifenesin/salbutamol in the treatment of productive cough in adult patients with acute bronch
Topics: Acute Disease; Adult; Albuterol; Ambroxol; Bromhexine; Bronchitis; Cough; Drug Combinations; Expecto | 2023 |
[Results of international multicentre non-interventional clinical study of the effectiveness and safety of ascoril expectorant for the treatment of cough in Kazakhstan and Uzbekistan].
Topics: Adolescent; Adrenergic beta-2 Receptor Agonists; Adult; Aged; Albuterol; Bromhexine; Child, Preschoo | 2013 |
[Therapeutic modalities for the management of cough associated with acute respiratory viral infection, effective in an otolaryngologist's practice].
Topics: Acute Disease; Adult; Albuterol; Ambroxol; Bromhexine; Bronchodilator Agents; Cough; Drug Combinatio | 2014 |
Antitussive effect of a fixed combination of Justicia adhatoda, Echinacea purpurea and Eleutherococcus senticosus extracts in patients with acute upper respiratory tract infection: A comparative, randomized, double-blind, placebo-controlled study.
Topics: Adult; Antitussive Agents; Bromhexine; Common Cold; Cough; Double-Blind Method; Echinacea; Eleuthero | 2015 |
Efficacy, safety and tolerability of salbutamol + guaiphenesin + bromhexine (Ascoril) expectorant versus expectorants containing salbutamol and either guaiphenesin or bromhexine in productive cough: a randomised controlled comparative study.
Topics: Adolescent; Adult; Aged; Albuterol; Bromhexine; Cough; Double-Blind Method; Drug Combinations; Expec | 2010 |
[Controlled clinical study of the treatment of chronic bronchitis with guacetisal].
Topics: Adult; Aged; Aspirin; Bromhexine; Bronchitis; Chronic Disease; Clinical Trials as Topic; Cough; Fema | 1981 |
[Treatment of bronchial inflammatory disorders with guacetisal].
Topics: Acute Disease; Aspirin; Bromhexine; Bronchitis; Carbonates; Chronic Disease; Clinical Trials as Topi | 1981 |
Studies on the removal of inhaled particles from the lungs by voluntary coughing.
Topics: Aerosols; Bromhexine; Cilia; Clinical Trials as Topic; Cough; Double-Blind Method; Humans; Lung; Lun | 1981 |
Clearance by voluntary coughing and its relationship to subjective assessment and effect of intravenous bromhexine.
Topics: Adult; Aged; Airway Obstruction; Bromhexine; Chronic Disease; Cough; Female; Humans; Male; Microsphe | 1981 |
Efficacy and safety of Ascoril expectorant and other cough formula in the treatment of cough management in paediatric and adult patients--a randomised double-blind comparative trial.
Topics: Adolescent; Adult; Albuterol; Ammonium Chloride; Bromhexine; Child; Child, Preschool; Citrates; Coug | 2000 |
[Clinical use of the combination prenoxidiazine-S-carboxy-methyl-cysteine].
Topics: Adult; Aged; Antitussive Agents; Bromhexine; Bronchial Diseases; Bronchial Spasm; Carbocysteine; Cli | 1979 |
Clinical efficacy of ambroxol in the treatment of bronchial stasis. Clinical trial in 120 patients at two different doses.
Topics: Adult; Aged; Ambroxol; Bromhexine; Bronchial Diseases; Clinical Trials as Topic; Cough; Dose-Respons | 1987 |
Ambroxol plus amoxicillin in the treatment of exacerbations of chronic bronchitis.
Topics: Adult; Aged; Aged, 80 and over; Ambroxol; Amoxicillin; Blood Gas Analysis; Bromhexine; Bronchitis; C | 1987 |
Other Studies
5 other studies available for bromhexine and Cough
| Article | Year |
|---|---|
[Ambroxol in bronchopulmonary pathology in children].
Topics: Ambroxol; Bromhexine; Bronchial Diseases; Bronchitis; Carbocysteine; Child; Child, Preschool; Cough; | 1983 |
The principles of drug action on cough and on sputum characteristics.
Topics: Aerosols; Antitussive Agents; Bromhexine; Cough; Disulfides; Glucocorticoids; Humans; Iodides; Mucus | 1980 |
Efficacy and safety of Ascoril in the management of cough--National Study Group report.
Topics: Adolescent; Adult; Aged; Bromhexine; Child; Child, Preschool; Cough; Drug Combinations; Expectorants | 2001 |
[Indication for drug therapy].
Topics: Adolescent; Age Factors; Analgesics; Antitussive Agents; Asthma; Bromhexine; Child; Child, Preschool | 1977 |
[Kinetics of mucus].
Topics: Acetylcysteine; Antitussive Agents; Bromhexine; Cough; Expectorants; Humans; Lung Diseases, Obstruct | 1990 |