baclofen has been researched along with Dystonia in 115 studies
Dystonia: An attitude or posture due to the co-contraction of agonists and antagonist muscles in one region of the body. It most often affects the large axial muscles of the trunk and limb girdles. Conditions which feature persistent or recurrent episodes of dystonia as a primary manifestation of disease are referred to as DYSTONIC DISORDERS. (Adams et al., Principles of Neurology, 6th ed, p77)
| Excerpt | Relevance | Reference |
|---|---|---|
| "To assess attainment of individual treatment goals one year after intrathecal baclofen (ITB) pump implantation in individuals with dyskinetic cerebral palsy (CP)." | 9.69 | Attainment of personal goals in the first year of intrathecal baclofen treatment in dyskinetic cerebral palsy: a prospective cohort study. ( Becher, JG; Bonouvrié, LA; Buizer, AI; Haberfehlner, H; Vermeulen, RJ; Vles, JSH, 2023) |
| " Intrathecal baclofen treatment is a potential treatment option for dystonia and has become common practice." | 9.17 | Intrathecal baclofen treatment in dystonic cerebral palsy: a randomized clinical trial: the IDYS trial. ( Becher, JG; Boeschoten, K; Bonouvrié, LA; de Groot, V; Foncke, E; Geytenbeek, J; Soudant, D; Strijers, R; Teernstra, O; van de Ven, PM; van Ouwerkerk, WJ; Vermeulen, RJ; Vles, JS, 2013) |
| "The 10 pain qualities of the neuropathic pain scale, dystonia severity, and changes in use of antinociceptive drugs were evaluated every 3 months for a period of 1 year in 42 CRPS patients with dystonia receiving titrated doses of intrathecal baclofen (ITB) treatment in an open design." | 9.17 | Efficacy of intrathecal baclofen on different pain qualities in complex regional pain syndrome. ( Marinus, J; Putter, H; van der Plas, AA; van Hilten, JJ; van Rijn, MA, 2013) |
| "Intrathecal baclofen (ITB) is effective in the treatment of dystonia related to complex regional pain syndrome (CRPS)." | 9.15 | The lack of efficacy of different infusion rates of intrathecal baclofen in complex regional pain syndrome: a randomized, double-blind, crossover study. ( Buchser, E; Eldabe, S; Marinus, J; van der Plas, AA; van Hilten, JJ, 2011) |
| "In this study we address clinimetric issues that pertain to the screening of responsiveness to intrathecal baclofen (ITB) in dystonia." | 9.09 | Clinimetric issues of screening for responsiveness to intrathecal baclofen in dystonia. ( Delhaas, EM; Hoff, JI; Thang, MC; van de Meerakker, MM; van Hilten, JJ; Voormolen, JH, 1999) |
| "In six women, bolus injections of 50 and 75 microg of baclofen resulted in complete or partial resolution of focal dystonia of the hands but little improvement in dystonia of the legs." | 9.09 | Intrathecal baclofen for the treatment of dystonia in patients with reflex sympathetic dystrophy. ( Delhaas, EM; Hoff, JI; van de Beek, WJ; van Hilten, BJ; Voormolen, JH, 2000) |
| "To study retrospectively the effects of IT baclofen in treating 25 patients with severe segmental or generalized dystonia." | 9.08 | Use of intrathecal baclofen in the treatment of patients with dystonia. ( Bressman, SB; Brin, MF; Fahn, S; Ford, B; Goodman, R; Greene, P; Louis, ED; Petzinger, G; Sadiq, S, 1996) |
| "Studies on the use of intrathecal baclofen (ITB) for ambulant adults with spasticity and/or dystonia of cerebral origin are scarce, and are even more limited for children and adolescents." | 8.87 | Use of intrathecal baclofen therapy in ambulant children and adolescents with spasticity and dystonia of cerebral origin: a systematic review. ( Lewis, J; McCartney, L; Pin, TW; Waugh, MC, 2011) |
| "The aim of the study was to evaluate the use of a novel technique for baclofen delivery using an intrathecal catheter inserted through a lumbar laminotomy with the tip placed at the cisterna magna (supraspinal baclofen (SSB)) for the treatment of severe generalized secondary dystonia." | 8.12 | Supraspinal baclofen for the treatment of secondary generalized dystonia: A case series. ( BeDell, KK; Ceverha, B; Wu, J; Yeh, BY, 2022) |
| "To investigate the effect of intrathecal baclofen (ITB) on function and activity in dyskinetic cerebral palsy (CP)." | 7.88 | Intrathecal baclofen in dyskinetic cerebral palsy: effects on function and activity. ( Askljung, B; Corneliusson, O; Eek, MN; Himmelmann, K; Lindh, K; Olsson, K; Påhlman, M, 2018) |
| "Treatment of severe spasticity and dystonia with intrathecal baclofen (ITB) in children has been shown to be effective and has therefore been employed in the Region of Southern Denmark." | 7.81 | Positive experience with intrathecal baclofen treatment in children with severe cerebral palsy. ( Illum, NO; Kjærsgaard-Hansen, L; Overgård, TM; Søe, M, 2015) |
| "Intrathecal baclofen is an effective treatment for spasticity in patients with cerebral palsy." | 7.76 | Do baclofen pumps influence the development of scoliosis in children? ( Burn, SC; Drake, JM; Zeller, R, 2010) |
| "The aim of this study was to evaluate the use of intraventricular baclofen (IVB) for the treatment of severe generalized secondary and heredodegenerative dystonia." | 7.75 | Intraventricular baclofen for dystonia: techniques and outcomes. Clinical article. ( Albright, AL; Ferson, SS, 2009) |
| "To describe complications and outcomes of intrathecal baclofen (ITB) therapy in children with spasticity and/or dystonia." | 7.75 | Continuous intrathecal baclofen for children with spasticity and/or dystonia: Goal attainment and complications associated with treatment. ( Dexter, M; Hayden, S; Scheinberg, A; Ward, A, 2009) |
| "Intrathecal baclofen (ITB) is a well-established method of treating spasticity in children with cerebral palsy." | 7.74 | The role of intrathecal baclofen in the management of primary and secondary dystonia in children. ( Tsegaye, M; Vloeberghs, MH; Woon, K, 2007) |
| "The literature available shows that spasticity in patients with cerebral palsy (CP) is reduced by intrathecal baclofen (ITB) treatment, and various studies suggest that this treatment can also be used in dystonic patients." | 7.74 | Effect of intrathecal baclofen on dystonia in children with cerebral palsy and the use of functional scales. ( Antonello, CE; Motta, F; Stignani, C, 2008) |
| "Two children with generalized dystonia were given continuous intraventricular baclofen (IVB) infusions." | 7.73 | Intraventricular baclofen infusion for dystonia. Report of two cases. ( Albright, AL, 2006) |
| "Continuous intrathecal baclofen was effective in treating severe spasticity and dystonia of cerebral origin with major effect on muscles of the lower extremities, pelvis, and back and in particular opisthotonus was relieved." | 7.72 | [Intrathecal baclofen in the treatment of severe spastic tetraplegia and dystonia in children and adolescents]. ( Fischer, C; Hansen, FJ; Illum, NO; Nielsen, OA; Uldall, PV, 2003) |
| "Dystonia diminished in 10 of 12 patients whose average daily dose of intrathecal baclofen was 575 microg." | 7.70 | Infusion of intrathecal baclofen for generalized dystonia in cerebral palsy. ( Albright, AL; Barry, MJ; Painter, MJ; Shultz, B, 1998) |
| "We observed a marked prolongation of the transcranially evoked silent period during continuous intrathecal administration of high doses of the gamma-aminobutyric acid (GABA)B receptor agonist baclofen in a patient with generalized dystonia." | 7.70 | Continuous intrathecal baclofen infusions induced a marked increase of the transcranially evoked silent period in a patient with generalized dystonia. ( Auer, C; Conrad, B; Dressnandt, J; Siebner, HR, 1998) |
| "Fourteen patients with primary or secondary dystonia received intrathecal baclofen (ITB) through an implanted pump following a trial dose." | 7.70 | Intrathecal baclofen for dystonia: benefits and complications during six years of experience. ( Brin, MF; Danisi, FO; Germano, IM; Goodman, RR; Swope, DM; Walker, RH, 2000) |
| "Five patients with generalized dystonia who were refractory to oral medications were treated by continuous intrathecal baclofen infusion." | 7.69 | Continuous intrathecal baclofen infusion for symptomatic generalized dystonia. ( Albright, AL; Barron, W; Barry, MJ; Fasick, P; Shultz, B, 1996) |
| "Treatment of tardive dystonia with oral baclofen produces ambivalent and overall disappointing results." | 7.69 | Severe tardive dystonia: treatment with continuous intrathecal baclofen administration. ( Dressler, D; Oeljeschläger, RO; Rüther, E, 1997) |
| "Baclofen benefits some patients with adult onset dystonia, but few reports document the response to baclofen of children with idiopathic dystonia." | 7.68 | Baclofen in the treatment of idiopathic dystonia in children. ( Fahn, S; Greene, PE, 1992) |
| "The use of baclofen, a structural analog of gamma-aminobutyric acid (GABA), is described in the treatment of a patient with tardive dystonia." | 7.67 | Baclofen treatment in a patient with tardive dystonia. ( Allen, A; Lux, WE; Rosse, RB, 1986) |
| "Dystonia in complex regional pain syndrome (CRPS) responds poorly to treatment." | 6.74 | Intrathecal baclofen for dystonia of complex regional pain syndrome. ( de Boer, KS; Delhaas, EM; Marinus, J; Munts, AG; Teepe-Twiss, IM; van Dasselaar, NT; van Hilten, JJ; van Rijn, MA; Voormolen, JH, 2009) |
| "Dystonia was associated with cerebral palsy in 71% of participants." | 6.70 | Intrathecal baclofen for generalized dystonia. ( Albright, AL; Barry, MJ; Ferson, SS; Shafton, DH, 2001) |
| "Baclofen is mainly an antispastic drug and the main indication of ITB is generalized lower limb spasticity in spinal cord injury and multiple sclerosis." | 6.44 | Intrathecal baclofen in the treatment of spasticity, dystonia and vegetative disorders. ( Menei, P; Richard, I, 2007) |
| "Sporadic cases of dramatic recovery from persistent vegetative state after intrathecal administration of baclofen have been reported." | 6.44 | Intrathecal baclofen in the treatment of post-stroke central pain, dystonia, and persistent vegetative state. ( Hori, T; Taira, T, 2007) |
| "Baclofen is also used for control of dystonia due to cerebral palsy or reflex sympathetic dystrophy." | 6.42 | Clinical application of drug pump for spasticity, pain, and restorative neurosurgery: other clinical applications of intrathecal baclofen. ( Hori, T; Taira, T, 2003) |
| "Baclofen has been used to treat several secondary dystonias: tardive dystonia has occasionally been reported to improve and there are isolated reports of improvement in dystonia occurring in Parkinson's disease and in glutaric aciduria." | 6.38 | Baclofen in the treatment of dystonia. ( Greene, P, 1992) |
| "To assess attainment of individual treatment goals one year after intrathecal baclofen (ITB) pump implantation in individuals with dyskinetic cerebral palsy (CP)." | 5.69 | Attainment of personal goals in the first year of intrathecal baclofen treatment in dyskinetic cerebral palsy: a prospective cohort study. ( Becher, JG; Bonouvrié, LA; Buizer, AI; Haberfehlner, H; Vermeulen, RJ; Vles, JSH, 2023) |
| "The treatment of spasticity and dystonia in these patients is difficult partly due to the relentless nature of this progressive disorder." | 5.48 | Intrathecal baclofen treatment an option in X-linked adrenoleukodystrophy. ( Ehrstedt, C; Hjartarson, HT; Tedroff, K, 2018) |
| "An infant with brachytelephalangic chondrodysplasia punctata developed flaccid tetraplegia due to cervical cord compression resulting from congenital atlantoaxial dislocation." | 5.43 | Effect of Intrathecal Baclofen on Delayed-Onset Paroxysmal Dystonia due to Compression Injury Resulting From Congenital and Progressive Spinal Bone Deformities in Chondrodysplasia Punctata. ( Honda, M; Horie, A; Maegaki, Y; Nagashima, H; Nishimura, Y; Ohno, K; Ohno, T; Okazaki, T; Saito, Y; Sugihara, S; Takenaka, A; Tamasaki, A; Togawa, M; Ueda, R, 2016) |
| "Treatment of children with movement disorders associated with CP increased slowly in the 1970s and 1980s but accelerated rapidly in the 1990s with the introduction of lumbar dorsal rhizotomies and intrathecal baclofen." | 5.41 | Spasticity and movement disorders in cerebral palsy. ( Albright, AL, 2023) |
| "Primary generalized dystonia usually evolves to a debilitating condition, often unresponsive to oral pharmacologic regimens or physical rehabilitation." | 5.31 | Intrathecal baclofen for generalized dystonia: a case report. ( Jaffe, MS; Nienstedt, LJ, 2001) |
| "We report a case of dystonia with a partial deletion of the short arm (p) of chromosome 18 and androgen insensitivity." | 5.30 | Progressive dystonia in a child with chromosome 18p deletion, treated with intrathecal baclofen. ( Awaad, Y; Munoz, S; Nigro, M, 1999) |
| " Intrathecal baclofen treatment is a potential treatment option for dystonia and has become common practice." | 5.17 | Intrathecal baclofen treatment in dystonic cerebral palsy: a randomized clinical trial: the IDYS trial. ( Becher, JG; Boeschoten, K; Bonouvrié, LA; de Groot, V; Foncke, E; Geytenbeek, J; Soudant, D; Strijers, R; Teernstra, O; van de Ven, PM; van Ouwerkerk, WJ; Vermeulen, RJ; Vles, JS, 2013) |
| "The 10 pain qualities of the neuropathic pain scale, dystonia severity, and changes in use of antinociceptive drugs were evaluated every 3 months for a period of 1 year in 42 CRPS patients with dystonia receiving titrated doses of intrathecal baclofen (ITB) treatment in an open design." | 5.17 | Efficacy of intrathecal baclofen on different pain qualities in complex regional pain syndrome. ( Marinus, J; Putter, H; van der Plas, AA; van Hilten, JJ; van Rijn, MA, 2013) |
| "Intrathecal baclofen (ITB) is effective in the treatment of dystonia related to complex regional pain syndrome (CRPS)." | 5.15 | The lack of efficacy of different infusion rates of intrathecal baclofen in complex regional pain syndrome: a randomized, double-blind, crossover study. ( Buchser, E; Eldabe, S; Marinus, J; van der Plas, AA; van Hilten, JJ, 2011) |
| "Seven children (aged 2-16 years) with dystonia of various aetiologies (dyskinetic cerebral palsy, pantothenate kinase-associated neurodegeneration and Aicardi-Goutières syndrome) underwent transcranial magnetic stimulation, H-reflex and flexor reflex studies before and after intrathecal injection of baclofen." | 5.11 | Electrophysiological assessment of the effect of intrathecal baclofen in dystonic children. ( Dachy, B; Dan, B, 2004) |
| "Continuous intrathecal infusion of baclofen is capable of maintaining a reduction in spasticity and dystonia in both the upper and lower extremities of TBI patients." | 5.09 | Long-term continuously infused intrathecal baclofen for spastic-dystonic hypertonia in traumatic brain injury: 1-year experience. ( Grabb, P; Guin-Renfroe, S; Hadley, MN; Meythaler, JM, 1999) |
| "In six women, bolus injections of 50 and 75 microg of baclofen resulted in complete or partial resolution of focal dystonia of the hands but little improvement in dystonia of the legs." | 5.09 | Intrathecal baclofen for the treatment of dystonia in patients with reflex sympathetic dystrophy. ( Delhaas, EM; Hoff, JI; van de Beek, WJ; van Hilten, BJ; Voormolen, JH, 2000) |
| "Searches included studies with a minimum of five participants with dystonia in CP receiving oral baclofen, benzodiazepines (clonazepam, diazepam, lorazepam), clonidine, gabapentin, levodopa, trihexyphenidyl, botulinum toxin, intrathecal baclofen (ITB), or deep brain stimulation (DBS)." | 4.98 | Pharmacological and neurosurgical interventions for managing dystonia in cerebral palsy: a systematic review. ( Brown, L; Fehlings, D; Harvey, A; Himmelmann, K; Lin, JP; Macintosh, A; Mink, JW; Monbaliu, E; Rice, J; Silver, J; Switzer, L; Walters, I, 2018) |
| "Intrathecal baclofen therapy, given via an implanted pump in the abdominal wall either as a continuous infusion or bolus dosing, has been used for more than 25 years to treat the spasticity and dystonia associated with various brain and spinal cord conditions." | 4.95 | Baclofen Pumps: Uses and Complications. ( Baum, CR; Woolf, SM, 2017) |
| "Medications such as anticholinergic drugs, dopamine modulators, baclofen, muscle relaxants, and other pharmacologic agents have been used for a long time to treat dystonia, but the introduction of botulinum toxin and deep brain stimulation clearly revolutionized the symptomatic treatment of this neurological movement disorder." | 4.89 | Medical treatment of dystonia. ( Jankovic, J, 2013) |
| "Studies on the use of intrathecal baclofen (ITB) for ambulant adults with spasticity and/or dystonia of cerebral origin are scarce, and are even more limited for children and adolescents." | 4.87 | Use of intrathecal baclofen therapy in ambulant children and adolescents with spasticity and dystonia of cerebral origin: a systematic review. ( Lewis, J; McCartney, L; Pin, TW; Waugh, MC, 2011) |
| "Для поиска статей по теме обзора использовали базу данных PubMed и ключевые слова «cerebral palsy», «spasticity», «dystonia», «selective dorsal rhizotomy», «selective neurotomy», «intrathecal baclofen therapy», «spinal cord stimulation», «deep brain stimulation»." | 4.31 | [Methods and results of neurosurgical treatment of cerebral palsy]. ( Dekopov, AV; Isagulyan, ED; Tomsky, AA, 2023) |
| "The aim of the study was to evaluate the use of a novel technique for baclofen delivery using an intrathecal catheter inserted through a lumbar laminotomy with the tip placed at the cisterna magna (supraspinal baclofen (SSB)) for the treatment of severe generalized secondary dystonia." | 4.12 | Supraspinal baclofen for the treatment of secondary generalized dystonia: A case series. ( BeDell, KK; Ceverha, B; Wu, J; Yeh, BY, 2022) |
| "This is a case of a 19-year-old male with a history of remote severe traumatic brain injury (TBI) with an intrathecal baclofen (ITB) pump for dystonia management." | 4.12 | Behavioral dysregulation exacerbated by intrathecal baclofen in an adolescent with severe traumatic brain injury. ( Lam, NY; Montagnino, J; Patel, H; Pham, K; Qin, ES, 2022) |
| "Intrathecal baclofen (ITB) is an effective treatment for managing primary and secondary dystonia." | 3.91 | Early intraventricular baclofen therapy (IVB) for children with dystonic and dysautonomic storm. ( Cinalli, G; Gilone, M; Graziano, S; Meccariello, G; Mirone, G; Ruggiero, C; Spennato, P, 2019) |
| "To investigate the effect of intrathecal baclofen (ITB) on function and activity in dyskinetic cerebral palsy (CP)." | 3.88 | Intrathecal baclofen in dyskinetic cerebral palsy: effects on function and activity. ( Askljung, B; Corneliusson, O; Eek, MN; Himmelmann, K; Lindh, K; Olsson, K; Påhlman, M, 2018) |
| "A 69-year-old woman with a history of hemodialysis-dependent end-stage renal disease presented to the Emergency Department with encephalopathy, ataxia, and dystonia after the addition of a recent baclofen prescription for back pain (10 mg twice daily)." | 3.85 | Baclofen Toxicity in a Patient with Hemodialysis-Dependent End-Stage Renal Disease. ( Katz, KD; Merrick, SS; Porter, LM, 2017) |
| "OBJECTIVE Medically refractory spasticity and dystonia are often alleviated with intrathecal baclofen (ITB) administration through an indwelling catheter inserted in the lumbar spine." | 3.85 | Image-guided intrathecal baclofen pump catheter implantation: a technical note and case series. ( Berde, C; Dasenbrock, HH; O'Brien, CP; Padua, H; Robertson, FC; Robinson, S, 2017) |
| ") in pediatric patients treated with intrathecal baclofen therapy (ITB) for spasticity and/or dystonia." | 3.83 | Comparison between an Ascenda and a silicone catheter in intrathecal baclofen therapy in pediatric patients: analysis of complications. ( Antonello, CE; Motta, F, 2016) |
| "Treatment of severe spasticity and dystonia with intrathecal baclofen (ITB) in children has been shown to be effective and has therefore been employed in the Region of Southern Denmark." | 3.81 | Positive experience with intrathecal baclofen treatment in children with severe cerebral palsy. ( Illum, NO; Kjærsgaard-Hansen, L; Overgård, TM; Søe, M, 2015) |
| " These patients often have spasticity and dystonia, both of which can be treated with intrathecal baclofen therapy." | 3.80 | Intrathecal baclofen therapy after liver transplant in a patient with Crigler-Najjar syndrome. ( Neufeld, JA; Pratini, NR, 2014) |
| "This single-center study investigated adverse events that occurred in children and adolescent patients treated with intrathecal baclofen (ITB) therapy for spasticity and/or dystonia." | 3.80 | Analysis of complications in 430 consecutive pediatric patients treated with intrathecal baclofen therapy: 14-year experience. ( Antonello, CE; Motta, F, 2014) |
| "Intrathecal baclofen (ITB) is a reversible treatment that reduces muscle tone to ameliorate spasticity and dystonia in patients with cerebral palsy (CP)." | 3.80 | Indwelling intrathecal catheter with subcutaneous abdominal reservoir: a viable baclofen delivery system in severely cachectic patients. ( Ellenbogen, JR; Kumar, R; Pettorini, BL; Sneade, C; Waqar, M; Williams, D; Zebian, B, 2014) |
| " All our patients underwent continuous infusion of midazolam, in association with pimozide and trihexyphenidyl, which led to complete resolution of muscular spasms in two patients." | 3.78 | Management of status dystonicus in children. Cases report and review. ( Balestri, P; Grosso, S; Messina, M; Sacchini, M; Verrotti, A, 2012) |
| "Intrathecal baclofen is an effective treatment for spasticity in patients with cerebral palsy." | 3.76 | Do baclofen pumps influence the development of scoliosis in children? ( Burn, SC; Drake, JM; Zeller, R, 2010) |
| "The GABA(B) receptor (GABA(B)R) agonist baclofen is known to have a beneficial potency in patients who suffer from dystonia, a neurological syndrome characterized by involuntary co-contractions of opposing muscles." | 3.75 | Pharmacological and autoradiographic studies on the pathophysiological role of GABA(B) receptors in the dystonic hamster: pronounced antidystonic effects of baclofen after striatal injections. ( Diwan, M; Lange, N; Nobrega, JN; Raymond, R; Richter, A; Richter, F; Sander, SE, 2009) |
| "To describe complications and outcomes of intrathecal baclofen (ITB) therapy in children with spasticity and/or dystonia." | 3.75 | Continuous intrathecal baclofen for children with spasticity and/or dystonia: Goal attainment and complications associated with treatment. ( Dexter, M; Hayden, S; Scheinberg, A; Ward, A, 2009) |
| "To describe the unusual course of postdural puncture headache (PDPH) after pump implantation for intrathecal baclofen (ITB) administration in patients with complex regional pain syndrome (CRPS)-related dystonia." | 3.75 | Postdural puncture headache in complex regional pain syndrome: a retrospective observational study. ( Delhaas, EM; Marinus, J; Munts, AG; van Hilten, JJ; Voormolen, JH, 2009) |
| "A 40-year-old man had an intrathecal morphine-baclofen pump inserted for the treatment of severe dystonia affecting all limbs and severe low back pain." | 3.74 | The complications of scar formation associated with intrathecal pump placement. ( Bundock, E; Graham, WA; Nero, C; Nesathurai, S; Protopapas, MG; Westmoreland, S, 2007) |
| "Intrathecal baclofen (ITB) is a well-established method of treating spasticity in children with cerebral palsy." | 3.74 | The role of intrathecal baclofen in the management of primary and secondary dystonia in children. ( Tsegaye, M; Vloeberghs, MH; Woon, K, 2007) |
| "The literature available shows that spasticity in patients with cerebral palsy (CP) is reduced by intrathecal baclofen (ITB) treatment, and various studies suggest that this treatment can also be used in dystonic patients." | 3.74 | Effect of intrathecal baclofen on dystonia in children with cerebral palsy and the use of functional scales. ( Antonello, CE; Motta, F; Stignani, C, 2008) |
| "Intrathecal baclofen therapy is an effective means of treating intractable spasticity and dystonia in the pediatric and adult population." | 3.73 | Identification and management of intrathecal baclofen pump complications: a comparison of pediatric and adult patients. ( Hester, S; Lee, MR; Rekito, A; Vender, JR; Waller, JL, 2006) |
| "Intrathecal baclofen (ITB) therapy is widely used in the management of spastic hypertonia and dystonia resulting from a multitude of conditions that present with upper motor neuron syndrome signs, such as cerebral palsy, stroke, brain and spinal injuries, and multiple sclerosis." | 3.73 | Successful treatment of posttraumatic hemiballismus with intrathecal baclofen therapy. ( Francisco, GE, 2006) |
| "Continuous intrathecal baclofen was effective in treating severe spasticity and dystonia of cerebral origin with major effect on muscles of the lower extremities, pelvis, and back and in particular opisthotonus was relieved." | 3.72 | [Intrathecal baclofen in the treatment of severe spastic tetraplegia and dystonia in children and adolescents]. ( Fischer, C; Hansen, FJ; Illum, NO; Nielsen, OA; Uldall, PV, 2003) |
| "We present the case of a 19-yr-old woman with a history of generalized dystonia who developed sudden onset of adductor spasms of the vocal cords and increased dystonia after the interruption or intrathecal baclofen therapy." | 3.72 | Respiratory distress after intrathecal baclofen withdrawal. ( Ahmed, SU; Hord, ED; Santiago-Palma, J; Trella, J; Vallejo, R, 2004) |
| "Intrathecal baclofen (ITB) can reduce spasticity in adults and children with cerebral palsy." | 3.71 | Improvement of sleep apnea in a patient with cerebral palsy. ( Gaebler-Spira, D; Harvey, RL; McCarty, SF, 2001) |
| " In particular, intrathecal baclofen therapy has shown efficacy and safety in the management of spasticity and dystonia in children." | 3.71 | Subfascial implantation of intrathecal baclofen pumps in children: technical note. ( Doyle, WK; Feldman, DS; Kopell, BH; Sala, D; Weiner, HL; Wisoff, JH, 2001) |
| "Dystonia diminished in 10 of 12 patients whose average daily dose of intrathecal baclofen was 575 microg." | 3.70 | Infusion of intrathecal baclofen for generalized dystonia in cerebral palsy. ( Albright, AL; Barry, MJ; Painter, MJ; Shultz, B, 1998) |
| "To test the efficacy of intrathecal baclofen in various movement disorders, 18 patients with dystonia, head trauma, cerebral palsy, rigidity, or painful spasms underwent a trial of intrathecal baclofen." | 3.69 | Intrathecal baclofen for motor disorders. ( Gianino, JM; Penn, RD; York, MM, 1995) |
| "Five patients with generalized dystonia who were refractory to oral medications were treated by continuous intrathecal baclofen infusion." | 3.69 | Continuous intrathecal baclofen infusion for symptomatic generalized dystonia. ( Albright, AL; Barron, W; Barry, MJ; Fasick, P; Shultz, B, 1996) |
| "We report a case of spinal myoclonus induced by the tip of an intrathecal catheter in a 35-year-old patient with severe, adult-onset, generalized dystonia of unknown cause, treated for 2 years using intrathecal baclofen." | 3.69 | Spinal myoclonus induced by an intrathecal catheter. ( Ford, B; Goodman, R; Khandji, A; Pullman, SL, 1997) |
| "The use of baclofen, a structural analog of gamma-aminobutyric acid (GABA), is described in the treatment of a patient with tardive dystonia." | 3.67 | Baclofen treatment in a patient with tardive dystonia. ( Allen, A; Lux, WE; Rosse, RB, 1986) |
| "For other causes of dystonia, and in particular dystonia due to acquired brain injury, improvements following surgery are more modest and variable." | 3.01 | Neurosurgical management of elevated tone in childhood: interventions, indications and uncertainties. ( Lumsden, DE, 2023) |
| "The average percent reduction in dystonia was 29." | 3.01 | Deep brain stimulation and intrathecal/intraventricular baclofen for glutaric aciduria type 1: A scoping review, individual patient data analysis, and clinical trials review. ( Hofmann, K; Keating, RF; Oluigbo, CO; Shlobin, NA, 2023) |
| "Dystonia in complex regional pain syndrome (CRPS) responds poorly to treatment." | 2.74 | Intrathecal baclofen for dystonia of complex regional pain syndrome. ( de Boer, KS; Delhaas, EM; Marinus, J; Munts, AG; Teepe-Twiss, IM; van Dasselaar, NT; van Hilten, JJ; van Rijn, MA; Voormolen, JH, 2009) |
| "Current guidelines in the treatments of dystonia, including oral therapy, are prescribed to improve symptoms and to restore functional capacity." | 2.72 | Dystonia and leveraging oral pharmacotherapy. ( Fernandez, HH; Sy, MAC, 2021) |
| "Dystonia was associated with cerebral palsy in 71% of participants." | 2.70 | Intrathecal baclofen for generalized dystonia. ( Albright, AL; Barry, MJ; Ferson, SS; Shafton, DH, 2001) |
| "In some of the most common genetic dystonias, such as those caused by TOR1A, THAP1, GCH1 and KMT2B mutations, and idiopathic dystonia, these mechanisms include abnormalities in transcriptional regulation, striatal dopaminergic signalling and synaptic plasticity and a loss of inhibition at neuronal circuits." | 2.58 | Dystonia. ( Balint, B; Bhatia, KP; Jankovic, J; Mencacci, NE; Pisani, A; Rothwell, J; Valente, EM; Vidailhet, M, 2018) |
| "A new less invasive treatment of tremor using MR guided focused ultrasound has started and is promising." | 2.49 | [Role of neurosurgical management in movement disorders other than Parkinson disease]. ( Taira, T, 2013) |
| "These include the management of dystonia and chronic neuropathic pain." | 2.44 | Intrathecal baclofen therapy for neurological disorders: a sound knowledge base but many challenges remain. ( Brennan, PM; Whittle, IR, 2008) |
| "Baclofen is mainly an antispastic drug and the main indication of ITB is generalized lower limb spasticity in spinal cord injury and multiple sclerosis." | 2.44 | Intrathecal baclofen in the treatment of spasticity, dystonia and vegetative disorders. ( Menei, P; Richard, I, 2007) |
| "Sporadic cases of dramatic recovery from persistent vegetative state after intrathecal administration of baclofen have been reported." | 2.44 | Intrathecal baclofen in the treatment of post-stroke central pain, dystonia, and persistent vegetative state. ( Hori, T; Taira, T, 2007) |
| "The treatment of dystonia has continued to evolve to include newer medications, different forms of botulinum toxin, and various surgical procedures." | 2.43 | Dystonia: genetics and treatment update. ( Bhidayasiri, R, 2006) |
| "Paroxysmal exercise-induced dystonia responds variably to anticonvulsant therapy, but the literature does not report response to baclofen, especially in low doses." | 2.42 | Post-traumatic paroxysmal exercise-induced dystonia: case report and review of the literature. ( Lim, EC; Wong, YS, 2003) |
| "Children with primary dystonia and those with tremor can be treated with deep brain stimulation of the internal globus pallidus and thalamus, respectively." | 2.42 | Neurosurgical treatment of spasticity and other pediatric movement disorders. ( Albright, AL, 2003) |
| "Baclofen is also used for control of dystonia due to cerebral palsy or reflex sympathetic dystrophy." | 2.42 | Clinical application of drug pump for spasticity, pain, and restorative neurosurgery: other clinical applications of intrathecal baclofen. ( Hori, T; Taira, T, 2003) |
| "Among the more common symptoms is spasticity." | 2.41 | Management of spasticity, pain, and paroxysmal phenomena in multiple sclerosis. ( Schapiro, RT, 2001) |
| " Central adverse effects, such as forgetfulness, can be reduced only by a reduction in dosage of the anticholinergic." | 2.37 | Systemic therapy of dystonia. ( Fahn, S, 1987) |
| "aspiration; children; dystonia; epilepsy; pneumonia." | 1.72 | Status Dystonicus with Atypical Presentation in Developmentally Delay Child: A Case Report. ( Dahal, S; Khati, N; Maharjan, G; Yadav, P; Yadav, SK, 2022) |
| "Isolated dystonia or spasticity was infrequently seen, with a mixed picture of dystonia and spasticity ± choreoathetosis identified in 194/275 (70." | 1.51 | Pharmacological management of abnormal tone and movement in cerebral palsy. ( Amin, S; Basu, A; Cadwgan, J; Crowe, B; DeAlwis, Y; Devlin, A; Kumar, R; Lodh, R; Lumsden, DE; Lundy, CT; Mordekar, SR; Smith, M, 2019) |
| "The treatment of spasticity and dystonia in these patients is difficult partly due to the relentless nature of this progressive disorder." | 1.48 | Intrathecal baclofen treatment an option in X-linked adrenoleukodystrophy. ( Ehrstedt, C; Hjartarson, HT; Tedroff, K, 2018) |
| "Oral baclofen was used by all doctors and was the first choice of 10 of 11." | 1.48 | Oral medication prescription practices of tertiary-based specialists for dystonia in children with cerebral palsy. ( Harvey, A; Reddihough, D; Scheinberg, A; Williams, K, 2018) |
| "Significant spasticity would usually be considered a contraindication for deep brain stimulation (DBS) and more suitably treated with intrathecal baclofen (ITB)." | 1.43 | Fractional anisotropy in children with dystonia or spasticity correlates with the selection for DBS or ITB movement disorder surgery. ( Ashkan, K; Ashmore, J; Ball, G; Charles-Edwards, G; Lin, JP; Lumsden, DE; Selway, R, 2016) |
| "An infant with brachytelephalangic chondrodysplasia punctata developed flaccid tetraplegia due to cervical cord compression resulting from congenital atlantoaxial dislocation." | 1.43 | Effect of Intrathecal Baclofen on Delayed-Onset Paroxysmal Dystonia due to Compression Injury Resulting From Congenital and Progressive Spinal Bone Deformities in Chondrodysplasia Punctata. ( Honda, M; Horie, A; Maegaki, Y; Nagashima, H; Nishimura, Y; Ohno, K; Ohno, T; Okazaki, T; Saito, Y; Sugihara, S; Takenaka, A; Tamasaki, A; Togawa, M; Ueda, R, 2016) |
| "Case note review of 278 children with dystonia referred to our service." | 1.43 | Medication use in childhood dystonia. ( Kaminska, M; Lin, JP; Lumsden, DE; Tomlin, S, 2016) |
| "All children are known to have severe dyskinetic cerebral palsy and presented with an acute or sub-acute deterioration in their symptoms." | 1.43 | Status dystonicus in children: Early recognition and treatment prevent serious complications. ( Abu-Arafeh, I; Combe, L, 2016) |
| "DYT16 is an autosomal recessive dystonia-parkinsonism due to putative mutations at PRKRA gene." | 1.38 | DYT16: the original cases. ( Camargos, S; Cardoso, F; Lees, AJ; Singleton, A, 2012) |
| "Baclofen concentration was quantified by high-pressure liquid chromatography and confirmed by injection onto a gas chromatograph." | 1.34 | Cerebrospinal fluid baclofen concentrations in patients undergoing continuous intrathecal baclofen therapy. ( Albright, AL; Carlos, S; Minnigh, MB; Thompson, K, 2007) |
| "We report a case of dystonia with a partial deletion of the short arm (p) of chromosome 18 and androgen insensitivity." | 1.30 | Progressive dystonia in a child with chromosome 18p deletion, treated with intrathecal baclofen. ( Awaad, Y; Munoz, S; Nigro, M, 1999) |
| "Three patients who had adult-onset dystonia and who were exhibiting respiratory problems were examined clinically and electrophysiologically." | 1.29 | Involvement of respiratory muscles in adult-onset dystonia: a clinical and electrophysiological study. ( Bergouignan, FX; Burbaud, P; Ferrer, X; Julien, J; Lagueny, A; Le Masson, G, 1995) |
| "Tardive dystonia is an uncommon, disabling side effect of antipsychotic medication that is generally believed to be resistant to treatment." | 1.28 | Tardive dystonia: four case histories. ( Korn, ML; Simpson, GM; Yadalam, KG, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (4.35) | 18.7374 |
| 1990's | 23 (20.00) | 18.2507 |
| 2000's | 38 (33.04) | 29.6817 |
| 2010's | 37 (32.17) | 24.3611 |
| 2020's | 12 (10.43) | 2.80 |
| Authors | Studies |
|---|---|
| Wu, J | 1 |
| Ceverha, B | 1 |
| Yeh, BY | 1 |
| BeDell, KK | 1 |
| Bonouvrié, LA | 2 |
| Haberfehlner, H | 1 |
| Becher, JG | 2 |
| Vles, JSH | 1 |
| Vermeulen, RJ | 2 |
| Buizer, AI | 1 |
| Qin, ES | 1 |
| Patel, H | 1 |
| Montagnino, J | 1 |
| Pham, K | 1 |
| Lam, NY | 1 |
| Lumsden, DE | 4 |
| Yadav, SK | 1 |
| Yadav, P | 1 |
| Maharjan, G | 1 |
| Dahal, S | 1 |
| Khati, N | 1 |
| Shlobin, NA | 1 |
| Hofmann, K | 1 |
| Keating, RF | 1 |
| Oluigbo, CO | 1 |
| Dekopov, AV | 1 |
| Tomsky, AA | 1 |
| Isagulyan, ED | 1 |
| Albright, AL | 9 |
| Grana, E | 1 |
| Peschi, L | 1 |
| Carda, S | 1 |
| Thomas, SP | 1 |
| Addison, AP | 1 |
| Curry, DJ | 1 |
| Bohn, E | 1 |
| Goren, K | 1 |
| Switzer, L | 2 |
| Falck-Ytter, Y | 1 |
| Fehlings, D | 2 |
| Sy, MAC | 1 |
| Fernandez, HH | 1 |
| Woolf, SM | 1 |
| Baum, CR | 1 |
| Evans, SH | 1 |
| Cameron, MW | 1 |
| Burton, JM | 1 |
| Hjartarson, HT | 1 |
| Ehrstedt, C | 1 |
| Tedroff, K | 1 |
| Harvey, A | 2 |
| Reddihough, D | 1 |
| Scheinberg, A | 2 |
| Williams, K | 1 |
| Eek, MN | 1 |
| Olsson, K | 1 |
| Lindh, K | 1 |
| Askljung, B | 1 |
| Påhlman, M | 1 |
| Corneliusson, O | 1 |
| Himmelmann, K | 2 |
| Brown, L | 1 |
| Lin, JP | 3 |
| Macintosh, A | 1 |
| Mink, JW | 1 |
| Monbaliu, E | 1 |
| Rice, J | 1 |
| Silver, J | 1 |
| Walters, I | 1 |
| Balint, B | 1 |
| Mencacci, NE | 1 |
| Valente, EM | 1 |
| Pisani, A | 1 |
| Rothwell, J | 1 |
| Jankovic, J | 4 |
| Vidailhet, M | 1 |
| Bhatia, KP | 1 |
| Ruggiero, C | 1 |
| Meccariello, G | 1 |
| Spennato, P | 1 |
| Mirone, G | 1 |
| Graziano, S | 1 |
| Gilone, M | 1 |
| Cinalli, G | 1 |
| Crowe, B | 1 |
| Basu, A | 1 |
| Amin, S | 1 |
| Devlin, A | 1 |
| DeAlwis, Y | 1 |
| Kumar, R | 2 |
| Lodh, R | 1 |
| Lundy, CT | 1 |
| Mordekar, SR | 1 |
| Smith, M | 1 |
| Cadwgan, J | 1 |
| Vles, JS | 2 |
| Boeschoten, K | 1 |
| Soudant, D | 1 |
| de Groot, V | 1 |
| van Ouwerkerk, WJ | 1 |
| Strijers, R | 1 |
| Foncke, E | 1 |
| Geytenbeek, J | 1 |
| van de Ven, PM | 1 |
| Teernstra, O | 1 |
| Taira, T | 3 |
| Pratini, NR | 1 |
| Neufeld, JA | 1 |
| Motta, F | 3 |
| Antonello, CE | 3 |
| Méndez-Lucena, C | 1 |
| Chacón Peña, J | 1 |
| García-Moreno, JM | 1 |
| Waqar, M | 1 |
| Ellenbogen, JR | 1 |
| Sneade, C | 1 |
| Zebian, B | 1 |
| Williams, D | 1 |
| Pettorini, BL | 1 |
| Overgård, TM | 1 |
| Kjærsgaard-Hansen, L | 1 |
| Søe, M | 1 |
| Illum, NO | 2 |
| Ashmore, J | 1 |
| Ball, G | 1 |
| Charles-Edwards, G | 1 |
| Selway, R | 1 |
| Ashkan, K | 1 |
| Okazaki, T | 1 |
| Saito, Y | 1 |
| Ueda, R | 1 |
| Sugihara, S | 1 |
| Tamasaki, A | 1 |
| Nishimura, Y | 1 |
| Ohno, K | 1 |
| Togawa, M | 1 |
| Ohno, T | 1 |
| Horie, A | 1 |
| Honda, M | 1 |
| Takenaka, A | 1 |
| Nagashima, H | 1 |
| Maegaki, Y | 1 |
| Kaminska, M | 1 |
| Tomlin, S | 1 |
| Ruan, X | 1 |
| Kaye, AD | 1 |
| Combe, L | 1 |
| Abu-Arafeh, I | 1 |
| Porter, LM | 1 |
| Merrick, SS | 1 |
| Katz, KD | 1 |
| Robinson, S | 1 |
| Robertson, FC | 1 |
| Dasenbrock, HH | 1 |
| O'Brien, CP | 1 |
| Berde, C | 1 |
| Padua, H | 1 |
| Brennan, PM | 1 |
| Whittle, IR | 1 |
| Chen, L | 1 |
| Wang, HT | 1 |
| Han, XH | 1 |
| Li, YL | 1 |
| Cui, QL | 1 |
| Xie, JX | 1 |
| Ferson, SS | 2 |
| van Rijn, MA | 3 |
| Munts, AG | 2 |
| Marinus, J | 4 |
| Voormolen, JH | 4 |
| de Boer, KS | 1 |
| Teepe-Twiss, IM | 1 |
| van Dasselaar, NT | 1 |
| Delhaas, EM | 4 |
| van Hilten, JJ | 6 |
| Raja, SN | 1 |
| Sander, SE | 1 |
| Richter, F | 1 |
| Raymond, R | 1 |
| Diwan, M | 1 |
| Lange, N | 1 |
| Nobrega, JN | 1 |
| Richter, A | 1 |
| Ward, A | 1 |
| Hayden, S | 1 |
| Dexter, M | 1 |
| Burn, SC | 1 |
| Zeller, R | 1 |
| Drake, JM | 1 |
| van der Plas, AA | 3 |
| Kumar, G | 1 |
| Sahaya, K | 1 |
| Goyal, MK | 1 |
| Sivaraman, M | 1 |
| Sahota, PK | 1 |
| Eldabe, S | 1 |
| Buchser, E | 1 |
| Specchio, N | 1 |
| Carotenuto, A | 1 |
| Trivisano, M | 1 |
| Cappelletti, S | 1 |
| Vigevano, F | 1 |
| Fusco, L | 1 |
| Pin, TW | 1 |
| McCartney, L | 1 |
| Lewis, J | 1 |
| Waugh, MC | 1 |
| Bassani, L | 1 |
| Harter, DH | 1 |
| Grosso, S | 1 |
| Verrotti, A | 1 |
| Messina, M | 1 |
| Sacchini, M | 1 |
| Balestri, P | 1 |
| Camargos, S | 1 |
| Lees, AJ | 1 |
| Singleton, A | 1 |
| Cardoso, F | 1 |
| Uchiyama, T | 1 |
| Nakanishi, K | 1 |
| Fukawa, N | 1 |
| Yoshioka, H | 1 |
| Murakami, S | 1 |
| Nakano, N | 1 |
| Kato, A | 1 |
| Putter, H | 1 |
| Hansen, FJ | 1 |
| Fischer, C | 1 |
| Uldall, PV | 1 |
| Nielsen, OA | 1 |
| Lim, EC | 1 |
| Wong, YS | 1 |
| Hori, T | 2 |
| Serrano-Dueñas, M | 1 |
| Dachy, B | 1 |
| Dan, B | 1 |
| Abbott, R | 1 |
| Santiago-Palma, J | 1 |
| Hord, ED | 1 |
| Vallejo, R | 1 |
| Trella, J | 1 |
| Ahmed, SU | 1 |
| Vender, JR | 1 |
| Hester, S | 1 |
| Waller, JL | 1 |
| Rekito, A | 1 |
| Lee, MR | 1 |
| Bhidayasiri, R | 1 |
| Turner, M | 1 |
| Pattisapu, JV | 1 |
| Francisco, GE | 1 |
| Protopapas, MG | 1 |
| Bundock, E | 1 |
| Westmoreland, S | 1 |
| Nero, C | 1 |
| Graham, WA | 1 |
| Nesathurai, S | 1 |
| Thompson, K | 1 |
| Carlos, S | 1 |
| Minnigh, MB | 1 |
| Woon, K | 1 |
| Tsegaye, M | 1 |
| Vloeberghs, MH | 1 |
| Richard, I | 1 |
| Menei, P | 1 |
| Ceulemans, B | 1 |
| van Rhijn, J | 1 |
| Kenis, S | 1 |
| Krols, R | 1 |
| Laridon, A | 1 |
| Van Havenbergh, T | 1 |
| Stignani, C | 1 |
| Gollomp, SM | 1 |
| Fahn, S | 5 |
| Burke, RE | 1 |
| Reches, A | 1 |
| Ilson, J | 1 |
| Ortiz, A | 1 |
| Brennan, MJ | 1 |
| Ruff, P | 1 |
| Sandyk, R | 1 |
| Penn, RD | 1 |
| Gianino, JM | 1 |
| York, MM | 1 |
| Kiziltan, G | 1 |
| Akalin, MA | 1 |
| Barry, MJ | 3 |
| Fasick, P | 1 |
| Barron, W | 1 |
| Shultz, B | 2 |
| Lagueny, A | 1 |
| Burbaud, P | 1 |
| Le Masson, G | 1 |
| Bergouignan, FX | 1 |
| Ferrer, X | 1 |
| Julien, J | 1 |
| Awaad, Y | 2 |
| Shamato, H | 1 |
| Chugani, H | 1 |
| Ford, B | 3 |
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| Petzinger, G | 1 |
| Bressman, SB | 2 |
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| Yadalam, KG | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Movement Impairment Characterization and Rehabilitation for Spastic/Dystonic Cerebral Palsy Using Robotic Haptic Feedback in Virtual Reality[NCT03744884] | 68 participants (Anticipated) | Interventional | 2018-12-01 | Recruiting | |||
| Intrathecal (IT) Baclofen Drug Distribution Pilot Study[NCT02903823] | Phase 4 | 27 participants (Actual) | Interventional | 2016-04-22 | Completed | ||
| Multi Center Project: Comparison of Functional Outcomes of Tendon Transfer Surgery, Botulinum Toxin Injections and Regular Ongoing Treatment in Hemiplegic Upper Extremity Cerebral Palsy[NCT00250081] | 38 participants (Actual) | Interventional | 2005-02-28 | Terminated (stopped due to Accrual is complete.) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"The Modified Ashworth Scale (MAS) is a 6-point scale (Standard MAS scale values: 0, 1, 1.5, 2, 3, or 4) used to evaluate spasticity based on grading muscle tone by moving joints. The MAS scores in this cohort are measured in biceps, triceps and forearm flexor muscles in upper extremities; and quadriceps, hamstrings and gastrocnemius muscles in lower extremities. The score ranges from 0 (no increase in muscle tone) to 4 (affected part(s) rigid in flexion or extension). Improvement in spasticity was a reduction in MAS score by 1 point across a joint tested. Maximal MAS change is the sum of MAS score reduction in all four limbs tested.~This outcome looks at subjects with spasticity of cerebral origin." (NCT02903823)
Timeframe: Baseline to 6 hours post-injection
| Intervention | Participants (Count of Participants) | |||
|---|---|---|---|---|
| Cervical level 4 injection site | Thoracic level 3 injection site | Thoracic level 10 injection site | Lumbar lever 2 injection site | |
| Subjects With Max MAS Change | 8 | 7 | 3 | 3 |
"The Modified Ashworth Scale (MAS) is a 6-point scale (Standard MAS scale values: 0, 1, 1.5, 2, 3, or 4) used to evaluate spasticity based on grading muscle tone by moving joints. The MAS scores in this cohort are measured in biceps, triceps and forearm flexor muscles in upper extremities; and quadriceps, hamstrings and gastrocnemius muscles in lower extremities. The score ranges from 0 (no increase in muscle tone) to 4 (affected part(s) rigid in flexion or extension). Improvement in spasticity was a reduction in MAS score by 1 point across a joint tested. Maximal MAS change is the sum of MAS score reduction in all four limbs tested.~This outcome looks at subjects with spasticity of spinal origin." (NCT02903823)
Timeframe: Baseline to 6 hours post-injection
| Intervention | Participants (Count of Participants) | |||
|---|---|---|---|---|
| Cervical spine level 4 injection site | Thoracic level 3 injection site | Thoracic level 10 injection site | Lumbar level 2 injection site | |
| Subjects With MAS Change - Based on Site of Injection | 4 | 2 | 5 | 3 |
25 reviews available for baclofen and Dystonia
| Article | Year |
|---|---|
Neurosurgical management of elevated tone in childhood: interventions, indications and uncertainties.
Topics: Baclofen; Cerebral Palsy; Child; Dystonia; Humans; Muscle Relaxants, Central; Muscle Spasticity; Rhi | 2023 |
Deep brain stimulation and intrathecal/intraventricular baclofen for glutaric aciduria type 1: A scoping review, individual patient data analysis, and clinical trials review.
Topics: Baclofen; Deep Brain Stimulation; Dystonia; Dystonic Disorders; Humans; Muscle Relaxants, Central; M | 2023 |
Spasticity and movement disorders in cerebral palsy.
Topics: Baclofen; Cerebral Palsy; Child; Dystonia; Humans; Movement Disorders; Muscle Relaxants, Central; Mu | 2023 |
Surgical Tone Reduction in Cerebral Palsy.
Topics: Baclofen; Cerebral Palsy; Deep Brain Stimulation; Dystonia; Humans; Injections, Spinal; Muscle Relax | 2020 |
Pharmacological and neurosurgical interventions for individuals with cerebral palsy and dystonia: a systematic review update and meta-analysis.
Topics: Baclofen; Botulinum Toxins; Cerebral Palsy; Clonidine; Deep Brain Stimulation; Dystonia; Humans; Inj | 2021 |
Dystonia and leveraging oral pharmacotherapy.
Topics: Baclofen; Dystonia; Dystonic Disorders; Humans; Muscle Contraction | 2021 |
Baclofen Pumps: Uses and Complications.
Topics: Baclofen; Brain Injuries; Dystonia; Humans; Infusion Pumps, Implantable; Reoperation; Spinal Cord In | 2017 |
Hypertonia.
Topics: Baclofen; Dystonia; Humans; Muscle Hypertonia; Muscle Relaxants, Central; Muscle Spasticity | 2017 |
Pharmacological and neurosurgical interventions for managing dystonia in cerebral palsy: a systematic review.
Topics: Baclofen; Cerebral Palsy; Deep Brain Stimulation; Dystonia; Humans; Muscle Relaxants, Central; Neuro | 2018 |
Dystonia.
Topics: Baclofen; Basal Ganglia; Botulinum Toxins, Type A; Dopamine Agents; Dystonia; Dystonic Disorders; GA | 2018 |
Medical treatment of dystonia.
Topics: Anti-Dyskinesia Agents; Baclofen; Botulinum Toxins; Cholinergic Antagonists; Disease Management; Dop | 2013 |
[Role of neurosurgical management in movement disorders other than Parkinson disease].
Topics: Baclofen; Deep Brain Stimulation; Dystonia; Humans; Injections, Spinal; Movement Disorders; Muscle S | 2013 |
Intrathecal baclofen therapy for neurological disorders: a sound knowledge base but many challenges remain.
Topics: Adult; Baclofen; Catheterization; Cerebral Palsy; Child; Child, Preschool; Dose-Response Relationshi | 2008 |
Use of intrathecal baclofen therapy in ambulant children and adolescents with spasticity and dystonia of cerebral origin: a systematic review.
Topics: Adolescent; Baclofen; Cerebral Cortex; Child; Databases, Factual; Dystonia; Electronic Health Record | 2011 |
Post-traumatic paroxysmal exercise-induced dystonia: case report and review of the literature.
Topics: Adult; Back Injuries; Baclofen; Dystonia; Exercise; Humans; Lumbosacral Region; Male; Muscle Relaxan | 2003 |
Neurosurgical treatment of spasticity and other pediatric movement disorders.
Topics: Athetosis; Baclofen; Child; Chorea; Dystonia; Electric Stimulation Therapy; GABA Agonists; Humans; I | 2003 |
Clinical application of drug pump for spasticity, pain, and restorative neurosurgery: other clinical applications of intrathecal baclofen.
Topics: Baclofen; Cerebrovascular Circulation; Dystonia; Electric Stimulation Therapy; Humans; Infusion Pump | 2003 |
Neurosurgical management of abnormal muscle tone in childhood.
Topics: Baclofen; Child; Dystonia; Electrodes, Implanted; Humans; Infusion Pumps, Implantable; Muscle Hypert | 2004 |
Dystonia: genetics and treatment update.
Topics: Baclofen; Botulinum Toxins; Cholinergic Antagonists; Dystonia; Dystonia Musculorum Deformans; GABA A | 2006 |
Intrathecal baclofen in the treatment of spasticity, dystonia and vegetative disorders.
Topics: Baclofen; Dystonia; Humans; Injections, Spinal; Muscle Relaxants, Central; Muscle Spasticity; Persis | 2007 |
Intrathecal baclofen in the treatment of post-stroke central pain, dystonia, and persistent vegetative state.
Topics: Baclofen; Dystonia; Humans; Muscle Relaxants, Central; Pain; Persistent Vegetative State; Stroke | 2007 |
Intrathecal baclofen in the treatment of dystonia.
Topics: Baclofen; Dystonia; Humans; Injections, Spinal; Muscle Relaxants, Central | 1998 |
Management of spasticity, pain, and paroxysmal phenomena in multiple sclerosis.
Topics: Acetates; Amines; Autoimmune Diseases; Baclofen; Benzodiazepines; Botulinum Toxins, Type A; Cannabin | 2001 |
Baclofen in the treatment of dystonia.
Topics: Baclofen; Dystonia; Humans | 1992 |
Systemic therapy of dystonia.
Topics: Adolescent; Adult; Baclofen; Benzodiazepines; Blepharospasm; Child; Dopamine; Dopamine Antagonists; | 1987 |
12 trials available for baclofen and Dystonia
| Article | Year |
|---|---|
Attainment of personal goals in the first year of intrathecal baclofen treatment in dyskinetic cerebral palsy: a prospective cohort study.
Topics: Baclofen; Cerebral Palsy; Child; Cohort Studies; Dystonia; Goals; Humans; Injections, Spinal; Muscle | 2023 |
Intrathecal baclofen treatment in dystonic cerebral palsy: a randomized clinical trial: the IDYS trial.
Topics: Activities of Daily Living; Adolescent; Adult; Baclofen; Brain; Cerebral Palsy; Child; Child, Presch | 2013 |
Intrathecal baclofen for dystonia of complex regional pain syndrome.
Topics: Adult; Baclofen; Complex Regional Pain Syndromes; Dose-Response Relationship, Drug; Dystonia; Female | 2009 |
The lack of efficacy of different infusion rates of intrathecal baclofen in complex regional pain syndrome: a randomized, double-blind, crossover study.
Topics: Adult; Baclofen; Complex Regional Pain Syndromes; Cross-Over Studies; Double-Blind Method; Drug Tole | 2011 |
Efficacy of intrathecal baclofen on different pain qualities in complex regional pain syndrome.
Topics: Adult; Baclofen; Complex Regional Pain Syndromes; Dose-Response Relationship, Drug; Dystonia; Female | 2013 |
Electrophysiological assessment of the effect of intrathecal baclofen in dystonic children.
Topics: Adult; Baclofen; Cerebral Palsy; Child; Child, Preschool; Dystonia; Evoked Potentials, Motor; Female | 2004 |
Therapeutic trials in Meige syndrome.
Topics: Adult; Aged; Baclofen; Benzodiazepines; Blepharospasm; Clinical Trials as Topic; Dopamine Antagonist | 1983 |
Use of intrathecal baclofen in the treatment of patients with dystonia.
Topics: Baclofen; Dystonia; Humans; Infusion Pumps, Implantable; Retrospective Studies; Spinal Cord | 1996 |
Long-term continuously infused intrathecal baclofen for spastic-dystonic hypertonia in traumatic brain injury: 1-year experience.
Topics: Adolescent; Adult; Analysis of Variance; Baclofen; Brain Injuries; Child; Dose-Response Relationship | 1999 |
Clinimetric issues of screening for responsiveness to intrathecal baclofen in dystonia.
Topics: Adolescent; Adult; Baclofen; Double-Blind Method; Dystonia; Female; Humans; Infusion Pumps; Injectio | 1999 |
Intrathecal baclofen for the treatment of dystonia in patients with reflex sympathetic dystrophy.
Topics: Adult; Baclofen; Cross-Over Studies; Double-Blind Method; Dystonia; Female; Follow-Up Studies; GABA | 2000 |
Intrathecal baclofen for generalized dystonia.
Topics: Adolescent; Adult; Baclofen; Cerebral Palsy; Child; Child, Preschool; Dystonia; Female; Follow-Up St | 2001 |
78 other studies available for baclofen and Dystonia
| Article | Year |
|---|---|
Supraspinal baclofen for the treatment of secondary generalized dystonia: A case series.
Topics: Baclofen; Cohort Studies; Dystonia; Dystonic Disorders; Humans; Infusion Pumps, Implantable; Muscle | 2022 |
Behavioral dysregulation exacerbated by intrathecal baclofen in an adolescent with severe traumatic brain injury.
Topics: Adolescent; Adult; Baclofen; Brain Injuries, Traumatic; Dystonia; Dystonic Disorders; Humans; Infusi | 2022 |
Status Dystonicus with Atypical Presentation in Developmentally Delay Child: A Case Report.
Topics: Baclofen; Child; Child, Preschool; Dystonia; Dystonic Disorders; Female; Gabapentin; Humans; Seizure | 2022 |
[Methods and results of neurosurgical treatment of cerebral palsy].
Topics: Baclofen; Cerebral Palsy; Dystonia; Humans; Muscle Spasticity; Neurosurgical Procedures; Paralysis; | 2023 |
Intrathecal baclofen as an effective treatment for generalized dystonia in Wilson's disease.
Topics: Baclofen; Dystonia; Hepatolenticular Degeneration; Humans; Treatment Outcome | 2023 |
Intrathecal baclofen treatment an option in X-linked adrenoleukodystrophy.
Topics: Adrenoleukodystrophy; Baclofen; Child; Dystonia; Dystonic Disorders; Humans; Infusion Pumps, Implant | 2018 |
Oral medication prescription practices of tertiary-based specialists for dystonia in children with cerebral palsy.
Topics: Administration, Oral; Adolescent; Australia; Baclofen; Central Nervous System Agents; Cerebral Palsy | 2018 |
Intrathecal baclofen in dyskinetic cerebral palsy: effects on function and activity.
Topics: Baclofen; Cerebral Palsy; Child; Dystonia; Female; Humans; Injections, Spinal; Male; Motor Activity; | 2018 |
Early intraventricular baclofen therapy (IVB) for children with dystonic and dysautonomic storm.
Topics: Adolescent; Autonomic Nervous System Diseases; Baclofen; Child; Dystonia; Female; Humans; Hypoxia, B | 2019 |
Pharmacological management of abnormal tone and movement in cerebral palsy.
Topics: Adolescent; Baclofen; Botulinum Toxins; Cerebral Palsy; Child; Child Health Services; Child, Prescho | 2019 |
Intrathecal baclofen therapy after liver transplant in a patient with Crigler-Najjar syndrome.
Topics: Baclofen; Crigler-Najjar Syndrome; Dystonia; Humans; Liver Transplantation; Male; Muscle Relaxants, | 2014 |
Analysis of complications in 430 consecutive pediatric patients treated with intrathecal baclofen therapy: 14-year experience.
Topics: Adolescent; Baclofen; Catheters, Indwelling; Cerebral Palsy; Child; Child, Preschool; Dystonia; Dyst | 2014 |
Intrathecal baclofen for dystonia treatment during pregnancy: A case report.
Topics: Adult; Baclofen; Cesarean Section; Dystonia; Female; Humans; Molecular Chaperones; Muscle Relaxants, | 2016 |
Indwelling intrathecal catheter with subcutaneous abdominal reservoir: a viable baclofen delivery system in severely cachectic patients.
Topics: Baclofen; Cachexia; Catheters, Indwelling; Cerebral Palsy; Child; Dystonia; Humans; Infusion Pumps, | 2014 |
Positive experience with intrathecal baclofen treatment in children with severe cerebral palsy.
Topics: Adolescent; Baclofen; Cerebral Palsy; Child; Child, Preschool; Denmark; Dystonia; Female; Humans; In | 2015 |
Fractional anisotropy in children with dystonia or spasticity correlates with the selection for DBS or ITB movement disorder surgery.
Topics: Adolescent; Anisotropy; Baclofen; Child; Child, Preschool; Deep Brain Stimulation; Diffusion Tensor | 2016 |
Effect of Intrathecal Baclofen on Delayed-Onset Paroxysmal Dystonia due to Compression Injury Resulting From Congenital and Progressive Spinal Bone Deformities in Chondrodysplasia Punctata.
Topics: Arthrogryposis; Baclofen; Child, Preschool; Chondrodysplasia Punctata; Dystonia; Hereditary Sensory | 2016 |
Medication use in childhood dystonia.
Topics: Adolescent; Antiparkinson Agents; Baclofen; Child; Chloral Hydrate; Cohort Studies; Diazepam; Drug-R | 2016 |
Letter to the Editor: Intrathecal baclofen trials: complications and positive yield in a pediatric cohort.
Topics: Baclofen; Child; Clinical Trials as Topic; Cohort Studies; Dystonia; Humans; Injections, Spinal; Mus | 2016 |
Comparison between an Ascenda and a silicone catheter in intrathecal baclofen therapy in pediatric patients: analysis of complications.
Topics: Adolescent; Baclofen; Catheters, Indwelling; Cerebrospinal Fluid Leak; Child; Child, Preschool; Dyst | 2016 |
Status dystonicus in children: Early recognition and treatment prevent serious complications.
Topics: Adolescent; Anti-Dyskinesia Agents; Athetosis; Baclofen; Cerebral Palsy; Child; Disease Progression; | 2016 |
Baclofen Toxicity in a Patient with Hemodialysis-Dependent End-Stage Renal Disease.
Topics: Aged; Ataxia; Back Pain; Baclofen; Brain Diseases; Confusion; Dystonia; Emergency Service, Hospital; | 2017 |
Image-guided intrathecal baclofen pump catheter implantation: a technical note and case series.
Topics: Adolescent; Adult; Anesthesia, General; Baclofen; Catheters, Indwelling; Cerebral Palsy; Cone-Beam C | 2017 |
Behavioral and electrophysiological effects of pallidal GABAB receptor activation and blockade on haloperidol-induced akinesia in rats.
Topics: Animals; Baclofen; Behavior, Animal; Dopamine Antagonists; Dystonia; Electrophysiology; Excitatory P | 2008 |
Intraventricular baclofen for dystonia: techniques and outcomes. Clinical article.
Topics: Baclofen; Cerebral Ventricles; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Admin | 2009 |
Motor dysfunction in CRPS and its treatment.
Topics: Baclofen; Complex Regional Pain Syndromes; Dystonia; Humans; Injections, Spinal; Muscle Relaxants, C | 2009 |
Pharmacological and autoradiographic studies on the pathophysiological role of GABA(B) receptors in the dystonic hamster: pronounced antidystonic effects of baclofen after striatal injections.
Topics: Animals; Animals, Genetically Modified; Autoradiography; Baclofen; Corpus Striatum; Cricetinae; Dyst | 2009 |
Continuous intrathecal baclofen for children with spasticity and/or dystonia: Goal attainment and complications associated with treatment.
Topics: Adolescent; Baclofen; Child; Child, Preschool; Dystonia; Female; Humans; Injections, Spinal; Male; M | 2009 |
Postdural puncture headache in complex regional pain syndrome: a retrospective observational study.
Topics: Adolescent; Adult; Anesthetics, Dissociative; Baclofen; Blood Patch, Epidural; Causality; Cerebrospi | 2009 |
Do baclofen pumps influence the development of scoliosis in children?
Topics: Adolescent; Aging; Baclofen; Cerebral Palsy; Child; Child, Preschool; Disease Progression; Dystonia; | 2010 |
Baclofen-induced chorea in complex regional pain syndrome-related dystonia.
Topics: Baclofen; Chorea; Dystonia; Female; Humans; Male; Middle Aged; Muscle Relaxants, Central; Pain | 2010 |
Electroencephalographic abnormalities in baclofen-induced encephalopathy.
Topics: Adult; Baclofen; Dystonia; Electroencephalography; Female; Humans; Muscle Relaxants, Central; Neurot | 2010 |
Prolonged episode of dystonia and dyskinesia resembling status epilepticus following acute intrathecal baclofen withdrawal.
Topics: Baclofen; Child; Dyskinesias; Dystonia; Electroencephalography; Female; Humans; Magnetic Resonance I | 2011 |
Intrathecal baclofen therapy in non-ambulant and ambulant children and adolescents with spasticity of cerebral origin.
Topics: Baclofen; Cerebral Cortex; Dystonia; Humans; Muscle Relaxants, Central; Muscle Spasticity | 2011 |
Paraspinal subfascial placement of lumbar intrathecal baclofen catheters: short-term outcomes of a novel technique.
Topics: Adolescent; Adult; Baclofen; Catheters, Indwelling; Cerebral Palsy; Child; Child, Preschool; Dystoni | 2012 |
Management of status dystonicus in children. Cases report and review.
Topics: Adolescent; Anti-Dyskinesia Agents; Baclofen; Brain; Case Management; Child; Cysts; Dystonia; Electr | 2012 |
DYT16: the original cases.
Topics: Adolescent; Adult; Age of Onset; Anti-Dyskinesia Agents; Antiparkinson Agents; Baclofen; Biperiden; | 2012 |
Neuromodulation using intrathecal baclofen therapy for spasticity and dystonia.
Topics: Adult; Baclofen; Dystonia; Female; GABA-B Receptor Agonists; Humans; Infusion Pumps, Implantable; In | 2012 |
[Intrathecal baclofen in the treatment of severe spastic tetraplegia and dystonia in children and adolescents].
Topics: Adolescent; Baclofen; Child; Child, Preschool; Dystonia; GABA Agonists; Humans; Infusion Pumps; Inje | 2003 |
Reflex sympathetic syndrome and peripheral dystonia.
Topics: Baclofen; Diagnosis, Differential; Dystonia; Female; Humans; Muscle Relaxants, Central; Peripheral N | 2003 |
Respiratory distress after intrathecal baclofen withdrawal.
Topics: Adult; Baclofen; Critical Care; Dyspnea; Dystonia; Female; Humans; Infusions, Intravenous; Injection | 2004 |
Identification and management of intrathecal baclofen pump complications: a comparison of pediatric and adult patients.
Topics: Adult; Age Factors; Baclofen; Child; Dystonia; GABA Agonists; Humans; Infusion Pumps, Implantable; M | 2006 |
Best-practice surgical techniques for intrathecal baclofen therapy.
Topics: Baclofen; Catheters, Indwelling; Cerebral Palsy; Child; Dystonia; Equipment Design; GABA Agonists; H | 2006 |
Intraventricular baclofen infusion for dystonia. Report of two cases.
Topics: Baclofen; Child; Dystonia; Female; Humans; Infusion Pumps, Implantable; Infusions, Parenteral; Male; | 2006 |
Successful treatment of posttraumatic hemiballismus with intrathecal baclofen therapy.
Topics: Adult; Baclofen; Brain Injuries; Dyskinesias; Dystonia; Humans; Infusion Pumps, Implantable; Injecti | 2006 |
The complications of scar formation associated with intrathecal pump placement.
Topics: Adult; Analgesics, Opioid; Baclofen; Catheters, Indwelling; Cicatrix; Dystonia; Equipment Failure An | 2007 |
Cerebrospinal fluid baclofen concentrations in patients undergoing continuous intrathecal baclofen therapy.
Topics: Adolescent; Adult; Baclofen; Child; Child, Preschool; Chromatography, Gas; Chromatography, High Pres | 2007 |
The role of intrathecal baclofen in the management of primary and secondary dystonia in children.
Topics: Adolescent; Adult; Baclofen; Cerebral Palsy; Child; Child, Preschool; Dystonia; Female; Humans; Infu | 2007 |
Opisthotonus and intrathecal treatment with baclofen (ITB) in children.
Topics: Adolescent; Adult; Baclofen; Belgium; Child; Child, Preschool; Dystonia; Epilepsy; Female; Follow-Up | 2008 |
Effect of intrathecal baclofen on dystonia in children with cerebral palsy and the use of functional scales.
Topics: Adolescent; Baclofen; Caregivers; Cerebral Palsy; Child; Child, Preschool; Disability Evaluation; Dy | 2008 |
Neuropharmacological profile of Meige's disease: overview and a case report.
Topics: Aged; Baclofen; Benztropine; Clonazepam; Doxepin; Drug Therapy, Combination; Dystonia; Facial Muscle | 1983 |
Efficacy of a combination of sodium valproate and baclofen in Meige's disease (idiopathic orofacial dystonia).
Topics: Baclofen; Drug Therapy, Combination; Dystonia; Facial Muscles; Humans; Male; Middle Aged; Valproic A | 1982 |
Intrathecal baclofen for motor disorders.
Topics: Adolescent; Adult; Baclofen; Cerebral Palsy; Craniocerebral Trauma; Dystonia; Female; Humans; Inject | 1995 |
Stuttering may be a type of action dystonia.
Topics: Adolescent; Adult; Baclofen; Biperiden; Brain Damage, Chronic; Dystonia; Humans; Male; Neurologic Ex | 1996 |
Continuous intrathecal baclofen infusion for symptomatic generalized dystonia.
Topics: Adolescent; Adult; Baclofen; Cerebral Palsy; Child; Dose-Response Relationship, Drug; Dystonia; Fema | 1996 |
Involvement of respiratory muscles in adult-onset dystonia: a clinical and electrophysiological study.
Topics: Administration, Oral; Aged; Baclofen; Botulinum Toxins; Delayed-Action Preparations; Diaphragm; Dyst | 1995 |
Hemidystonia improved by baclofen and PET scan findings in a patient with glutaric aciduria type I.
Topics: Baclofen; Child, Preschool; Corpus Striatum; Diet Therapy; Dystonia; Electroencephalography; Humans; | 1996 |
Risks of electronic publishing.
Topics: Baclofen; Dyskinesia, Drug-Induced; Dystonia; Humans; Injections, Spinal; Publishing; Word Processin | 1997 |
Severe tardive dystonia: treatment with continuous intrathecal baclofen administration.
Topics: Antipsychotic Agents; Baclofen; Blood-Brain Barrier; Drug Resistance; Dystonia; Female; GABA Agonist | 1997 |
Spinal myoclonus induced by an intrathecal catheter.
Topics: Adult; Baclofen; Catheterization; Dystonia; Electromyography; Female; Humans; Injections, Spinal; Mu | 1997 |
Sustained effect of high-dose intrathecal baclofen in primary generalized dystonia: a 2-year follow-up study.
Topics: Adult; Baclofen; Botulinum Toxins, Type A; Catheters, Indwelling; Dose-Response Relationship, Drug; | 1997 |
Infusion of intrathecal baclofen for generalized dystonia in cerebral palsy.
Topics: Adolescent; Adult; Baclofen; Cerebral Palsy; Child; Child, Preschool; Dystonia; Female; Humans; Inje | 1998 |
Continuous intrathecal baclofen infusions induced a marked increase of the transcranially evoked silent period in a patient with generalized dystonia.
Topics: Adult; Baclofen; Dose-Response Relationship, Drug; Dystonia; Electromyography; Evoked Potentials, Mo | 1998 |
Progressive dystonia in a child with chromosome 18p deletion, treated with intrathecal baclofen.
Topics: Adolescent; Baclofen; Chromosome Aberrations; Chromosome Deletion; Chromosome Disorders; Chromosomes | 1999 |
Influence of intrathecal baclofen on silent periods in dystonia.
Topics: Baclofen; Dystonia; Electric Stimulation Therapy; Female; Humans; Injections, Spinal; Middle Aged; M | 2000 |
New treatments for reflex sympathetic dystrophy.
Topics: Baclofen; Dystonia; Electric Stimulation Therapy; GABA Agonists; Humans; Reflex Sympathetic Dystroph | 2000 |
Intrathecal baclofen for dystonia: benefits and complications during six years of experience.
Topics: Adult; Baclofen; Dystonia; Female; Humans; Infusion Pumps, Implantable; Injections, Spinal; Male; Mi | 2000 |
Intrathecal baclofen for generalized dystonia: a case report.
Topics: Aged; Baclofen; Dystonia; GABA Agonists; Humans; Infusion Pumps, Implantable; Injections, Spinal; Ma | 2001 |
Improvement of sleep apnea in a patient with cerebral palsy.
Topics: Adult; Baclofen; Cerebral Palsy; Dystonia; Female; Humans; Injections, Spinal; Muscle Spasticity; Po | 2001 |
Subfascial implantation of intrathecal baclofen pumps in children: technical note.
Topics: Adolescent; Baclofen; Child; Child, Preschool; Dystonia; Follow-Up Studies; Humans; Infusion Pumps, | 2001 |
Intrathecal baclofen for dystonia.
Topics: Adult; Aged; Baclofen; Dystonia; Female; Follow-Up Studies; Humans; Infusion Pumps, Implantable; Inj | 2001 |
Baclofen in the treatment of idiopathic dystonia in children.
Topics: Adolescent; Baclofen; Child; Dose-Response Relationship, Drug; Dystonia; Female; Gait; Humans; Male; | 1992 |
A case of baclofen-induced psychotic depression.
Topics: Adult; Baclofen; Delusions; Depressive Disorder; Dystonia; Humans; Male; Psychoses, Substance-Induce | 1992 |
Increased dystonia after intrathecal baclofen.
Topics: Adult; Baclofen; Dystonia; Female; Humans; Injections, Spinal | 1992 |
Effects of pharmacological manipulation of GABAergic neurotransmission in a new mutant hamster model of paroxysmal dystonia.
Topics: Animals; Baclofen; Carbamazepine; Cricetinae; Diazepam; Disease Models, Animal; Dystonia; gamma-Amin | 1991 |
Tardive dystonia: four case histories.
Topics: Adult; Antipsychotic Agents; Baclofen; Benzodiazepines; Bipolar Disorder; Dyskinesia, Drug-Induced; | 1990 |
Intrathecal baclofen for intractable axial dystonia.
Topics: Adolescent; Baclofen; Birth Injuries; Brain Damage, Chronic; Dystonia; Humans; Infusion Pumps; Injec | 1991 |
Baclofen treatment in a patient with tardive dystonia.
Topics: Aged; Alzheimer Disease; Baclofen; Dystonia; Female; Haloperidol; Humans | 1986 |