Page last updated: 2024-10-23

baclofen and Cough

baclofen has been researched along with Cough in 29 studies

Cough: A sudden, audible expulsion of air from the lungs through a partially closed glottis, preceded by inhalation. It is a protective response that serves to clear the trachea, bronchi, and/or lungs of irritants and secretions, or to prevent aspiration of foreign materials into the lungs.

Research Excerpts

ExcerptRelevanceReference
"To compare the efficacy of gabapentin and baclofen in patients with suspected refractory gastro-oesophageal reflux-induced chronic cough."9.30Randomised clinical trial: gabapentin vs baclofen in the treatment of suspected refractory gastro-oesophageal reflux-induced chronic cough. ( Chen, Q; Ding, H; Dong, R; Lv, H; Pan, J; Qiu, Z; Shi, C; Xu, X; Yu, L; Yu, Y; Zhang, M, 2019)
"To determine whether baclofen can suppress the cough induced by angiotensin-converting enzyme (ACE) inhibitors."9.08Use of baclofen to suppress cough induced by angiotensin-converting enzyme inhibitors. ( Dicpinigaitis, PV, 1996)
"Therapeutic efficacy of baclofen is suboptimal in the treatment of refractory gastroesophageal reflux-induced chronic cough (GERC)."8.02Pressure and length of the lower esophageal sphincter as predictive indicators of therapeutic efficacy of baclofen for refractory gastroesophageal reflux-induced chronic cough. ( Qiu, Z; Si, F; Sun, H; Xu, X; Yu, L; Zhang, M; Zhu, Y, 2021)
"To evaluate the efficacy and safety of baclofen for treatment of refractory gastroesophageal reflux-induced chronic cough (GERC) unresponsive to standard anti-reflux therapy."7.79Therapeutic efficacy of baclofen in refractory gastroesophageal reflux-induced chronic cough. ( Chen, Q; Liang, SW; Lv, HJ; Qiu, ZM; Xu, XH; Yang, ZM; Yu, L, 2013)
"In this study, the effects of atropine sulfate (atropine) on swallowing and cough reflex were evaluated in the two experimental models in conscious dogs."7.74Swallowing disorder and inhibition of cough reflex induced by atropine sulfate in conscious dogs. ( Katsura, Y; Mino, T; Seki, T; Sugimoto, S; Tsubouchi, T; Tsujimoto, S, 2008)
"To determine the effect of the GABA-agonist baclofen on cough reflex sensitivity in subjects with cervical spinal cord injury (C-SCI)."7.70Baclofen-induced cough suppression in cervical spinal cord injury. ( Dicpinigaitis, PV; Grimm, DR; Lesser, M, 2000)
" Cough responses to inhaled capsaicin were assessed at screening and 2h post-dose on each study day."5.41Effect of centrally and peripherally acting GABA ( Badri, H; Canning, BJ; Denton, D; Dockry, RJ; Escott, J; Holt, A; Holt, K; LGibbard, C; Satia, I; Smith, JA; Wilkinson, G, 2021)
"Cough was elicited by mechanical stimulation of the lumen of the intrathoracic trachea in spontaneously breathing cats."5.39Influence of baclofen on laryngeal and spinal motor drive during cough in the anesthetized cat. ( Castillo, D; Pitts, T, 2013)
"To compare the efficacy of gabapentin and baclofen in patients with suspected refractory gastro-oesophageal reflux-induced chronic cough."5.30Randomised clinical trial: gabapentin vs baclofen in the treatment of suspected refractory gastro-oesophageal reflux-induced chronic cough. ( Chen, Q; Ding, H; Dong, R; Lv, H; Pan, J; Qiu, Z; Shi, C; Xu, X; Yu, L; Yu, Y; Zhang, M, 2019)
" The GABA-agonist baclofen has been shown, in animal studies, to inhibit cough via a central mechanism, but has not been investigated in humans (to our knowledge)."5.08Antitussive effect of the GABA-agonist baclofen. ( Dicpinigaitis, PV; Dobkin, JB, 1997)
"The goal of this systematic review was to examine the evidence for the use of the neuromodulating agents, amitriptyline, gabapentin, pregabalin, and baclofen, in the management of chronic, idiopathic cough patients."4.89Use of specific neuromodulators in the treatment of chronic, idiopathic cough: a systematic review. ( Cohen, SM; Misono, S, 2013)
"Therapeutic efficacy of baclofen is suboptimal in the treatment of refractory gastroesophageal reflux-induced chronic cough (GERC)."4.02Pressure and length of the lower esophageal sphincter as predictive indicators of therapeutic efficacy of baclofen for refractory gastroesophageal reflux-induced chronic cough. ( Qiu, Z; Si, F; Sun, H; Xu, X; Yu, L; Zhang, M; Zhu, Y, 2021)
"Non-acid GERC had the similar cough character, cough symptom score, and capsaicin cough sensitivity to acid GERC."3.81Comparison of clinical characteristics of chronic cough due to non-acid and acid gastroesophageal reflux. ( Chen, Q; Liang, S; Lü, H; Qiu, Z; Xu, X; Yang, Z; Yu, L, 2015)
"To evaluate the efficacy and safety of baclofen for treatment of refractory gastroesophageal reflux-induced chronic cough (GERC) unresponsive to standard anti-reflux therapy."3.79Therapeutic efficacy of baclofen in refractory gastroesophageal reflux-induced chronic cough. ( Chen, Q; Liang, SW; Lv, HJ; Qiu, ZM; Xu, XH; Yang, ZM; Yu, L, 2013)
"We studied the influence of memantine on experimentally induced coughing in response to citric acid and bradykinin inhalation in guinea pigs."3.78Antitussive effects of memantine in guinea pigs. ( Canning, BJ; Hilton, ECY; Saulsberry, L; Smith, JA, 2012)
"In this study, the effects of atropine sulfate (atropine) on swallowing and cough reflex were evaluated in the two experimental models in conscious dogs."3.74Swallowing disorder and inhibition of cough reflex induced by atropine sulfate in conscious dogs. ( Katsura, Y; Mino, T; Seki, T; Sugimoto, S; Tsubouchi, T; Tsujimoto, S, 2008)
"To determine the effect of the GABA-agonist baclofen on cough reflex sensitivity in subjects with cervical spinal cord injury (C-SCI)."3.70Baclofen-induced cough suppression in cervical spinal cord injury. ( Dicpinigaitis, PV; Grimm, DR; Lesser, M, 2000)
"Chronic cough is a common symptom that can be difficult to treat."2.52NMDA and GABA receptors as potential targets in cough hypersensitivity syndrome. ( Chung, KF, 2015)
"Bicuculline and saclofen were microinjected into the rostral (rNTS) and caudal nucleus of the solitary tract (cNTS) in 17 anesthetized cats."1.91Differential inhibition of cough by GABA ( Cibulkova, L; Kotmanova, Z; Martvon, L; Poliacek, I; Simera, M; Veternik, M, 2023)
"Cough was elicited by mechanical stimulation of the lumen of the intrathoracic trachea in spontaneously breathing cats."1.39Influence of baclofen on laryngeal and spinal motor drive during cough in the anesthetized cat. ( Castillo, D; Pitts, T, 2013)
" Dose-response relationships for i."1.29Peripheral and central sites of action of GABA-B agonists to inhibit the cough reflex in the cat and guinea pig. ( Bolser, DC; Chapman, RW; DeGennaro, FC; Egan, RW; Hey, JA; Kreutner, W; O'Reilly, S, 1994)
"Cough is a prominent symptom of pulmonary disease, but the effects of GABAB agonists on this airway reflex are unknown."1.29Antitussive effects of GABAB agonists in the cat and guinea-pig. ( Aziz, SM; Bolser, DC; Chapman, RW; DeGennaro, FC; Egan, RW; Kreutner, W; Siegel, MI, 1993)

Research

Studies (29)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's9 (31.03)18.2507
2000's5 (17.24)29.6817
2010's11 (37.93)24.3611
2020's4 (13.79)2.80

Authors

AuthorsStudies
Badri, H1
LGibbard, C1
Denton, D1
Satia, I1
Dockry, RJ1
Holt, K1
Escott, J1
Wilkinson, G1
Holt, A1
Canning, BJ2
Smith, JA2
Simera, M3
Veternik, M3
Martvon, L3
Kotmanova, Z3
Cibulkova, L1
Poliacek, I3
Dobrolubov, B1
Babalova, L1
Pitts, T3
Jakus, J2
Zhu, Y1
Xu, X4
Zhang, M2
Si, F1
Sun, H1
Yu, L5
Qiu, Z4
Misek, J1
Shen, TY1
Musselwhite, MN1
Bolser, DC4
Dong, R2
Ding, H1
Pan, J1
Yu, Y1
Shi, C1
Chen, Q3
Lv, H1
Naik, RD1
Vaezi, MF1
Castillo, D1
Xu, XH1
Yang, ZM1
Liang, SW1
Lv, HJ1
Qiu, ZM1
Yang, Z1
Liang, S1
Lü, H1
Chung, KF1
Mutolo, D2
Bongianni, F2
Cinelli, E2
Pantaleo, T2
Hilton, ECY1
Saulsberry, L1
Cohen, SM1
Misono, S1
Dykewicz, MS1
Tsubouchi, T1
Tsujimoto, S1
Sugimoto, S1
Katsura, Y1
Mino, T1
Seki, T1
Fontana, GA1
DeGennaro, FC2
O'Reilly, S1
Chapman, RW3
Kreutner, W2
Egan, RW2
Hey, JA2
Aziz, SM1
Siegel, MI1
Rizzo, CA1
Dicpinigaitis, PV5
Dobkin, JB2
Rauf, K2
Aldrich, TK1
Beraldo, PS1
Mateus, SR1
Fernandes, MC1
Grimm, DR1
Lesser, M1
Callaway, JK1
King, RG1
Bhalotra, R1

Reviews

4 reviews available for baclofen and Cough

ArticleYear
NMDA and GABA receptors as potential targets in cough hypersensitivity syndrome.
    Current opinion in pharmacology, 2015, Volume: 22

    Topics: Animals; Antitussive Agents; Baclofen; Chronic Disease; Cough; GABA-B Receptor Agonists; Humans; Hyp

2015
Use of specific neuromodulators in the treatment of chronic, idiopathic cough: a systematic review.
    Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2013, Volume: 148, Issue:3

    Topics: Amines; Amitriptyline; Baclofen; Chronic Disease; Cough; Cyclohexanecarboxylic Acids; Gabapentin; ga

2013
Cough and angioedema from angiotensin-converting enzyme inhibitors: new insights into mechanisms and management.
    Current opinion in allergy and clinical immunology, 2004, Volume: 4, Issue:4

    Topics: Angioedema; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Anti-Asthmat

2004
GABAB receptors in the lung.
    Trends in pharmacological sciences, 1993, Volume: 14, Issue:1

    Topics: Anaphylaxis; Animals; Baclofen; Cough; gamma-Aminobutyric Acid; Humans; Lung; Neurons, Afferent; Par

1993

Trials

6 trials available for baclofen and Cough

ArticleYear
Effect of centrally and peripherally acting GABA
    Pulmonary pharmacology & therapeutics, 2021, Volume: 71

    Topics: Adult; Animals; Baclofen; Capsaicin; Cough; Double-Blind Method; Female; Humans; Reflex

2021
Randomised clinical trial: gabapentin vs baclofen in the treatment of suspected refractory gastro-oesophageal reflux-induced chronic cough.
    Alimentary pharmacology & therapeutics, 2019, Volume: 49, Issue:6

    Topics: Adult; Analgesics; Baclofen; Chronic Disease; Cough; Dose-Response Relationship, Drug; Female; Follo

2019
Use of baclofen to suppress cough induced by angiotensin-converting enzyme inhibitors.
    The Annals of pharmacotherapy, 1996, Volume: 30, Issue:11

    Topics: Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Baclofen; Cough; Female; GABA Agonists; Human

1996
Antitussive effect of the GABA-agonist baclofen.
    Chest, 1997, Volume: 111, Issue:4

    Topics: Adult; Antitussive Agents; Baclofen; Capsaicin; Cough; Double-Blind Method; Female; GABA Agonists; H

1997
Treatment of chronic, refractory cough with baclofen.
    Respiration; international review of thoracic diseases, 1998, Volume: 65, Issue:1

    Topics: Administration, Oral; Adult; Aged; Baclofen; Bronchial Provocation Tests; Capsaicin; Chronic Disease

1998
Inhibition of capsaicin-induced cough by the gamma-aminobutyric acid agonist baclofen.
    Journal of clinical pharmacology, 1998, Volume: 38, Issue:4

    Topics: Administration, Oral; Adult; Antitussive Agents; Baclofen; Capsaicin; Cough; Double-Blind Method; GA

1998

Other Studies

19 other studies available for baclofen and Cough

ArticleYear
Differential inhibition of cough by GABA
    Respiratory physiology & neurobiology, 2023, Volume: 315

    Topics: Animals; Baclofen; Bicuculline; Cats; Cough; GABA-B Receptor Antagonists; Microinjections; Solitary

2023
Modulation of Cough Reflex by Gaba-Ergic Inhibition in Medullary Raphé of the Cat.
    Physiological research, 2020, 03-27, Volume: 69, Issue:Suppl 1

    Topics: Animals; Baclofen; Cats; Cough; GABA-A Receptor Agonists; GABA-B Receptor Agonists; Medulla Oblongat

2020
Pressure and length of the lower esophageal sphincter as predictive indicators of therapeutic efficacy of baclofen for refractory gastroesophageal reflux-induced chronic cough.
    Respiratory medicine, 2021, Volume: 183

    Topics: Baclofen; Chronic Disease; Cough; Esophageal Sphincter, Lower; Female; Gastroesophageal Reflux; Huma

2021
GABA-ergic neurotransmission in the nucleus of the solitary tract modulates cough in the cat.
    Respiratory physiology & neurobiology, 2018, Volume: 257

    Topics: Animals; Baclofen; Blood Pressure; Cats; Cough; Esophagus; gamma-Aminobutyric Acid; Heart Rate; Inha

2018
Editorial: breaking the cycle of cough in GERD-neuromodulators to the rescue? Authors' reply.
    Alimentary pharmacology & therapeutics, 2019, Volume: 49, Issue:9

    Topics: Baclofen; Cough; Gabapentin; Gastroesophageal Reflux; Humans; Neurotransmitter Agents

2019
Editorial: breaking the cycle of cough in GERD-neuromodulators to the rescue?
    Alimentary pharmacology & therapeutics, 2019, Volume: 49, Issue:9

    Topics: Baclofen; Cough; Gabapentin; Gastroesophageal Reflux; Humans; Neurotransmitter Agents

2019
Influence of baclofen on laryngeal and spinal motor drive during cough in the anesthetized cat.
    The Laryngoscope, 2013, Volume: 123, Issue:12

    Topics: Animals; Baclofen; Cats; Cough; Disease Models, Animal; Dose-Response Relationship, Drug; Electromyo

2013
Therapeutic efficacy of baclofen in refractory gastroesophageal reflux-induced chronic cough.
    World journal of gastroenterology, 2013, Jul-21, Volume: 19, Issue:27

    Topics: Adult; Baclofen; Capsaicin; Cohort Studies; Cough; Domperidone; Esophageal pH Monitoring; Female; Ga

2013
Comparison of clinical characteristics of chronic cough due to non-acid and acid gastroesophageal reflux.
    The clinical respiratory journal, 2015, Volume: 9, Issue:2

    Topics: Adult; Anti-Ulcer Agents; Baclofen; Capsaicin; Chronic Disease; Cough; Domperidone; Esophageal pH Mo

2015
Depression of cough reflex by microinjections of antitussive agents into caudal ventral respiratory group of the rabbit.
    Journal of applied physiology (Bethesda, Md. : 1985), 2010, Volume: 109, Issue:4

    Topics: Abdominal Muscles; Animals; Antitussive Agents; Baclofen; Cough; Diaphragm; Electromyography; Enkeph

2010
Antitussive effects of memantine in guinea pigs.
    Chest, 2012, Volume: 141, Issue:4

    Topics: Animals; Antitussive Agents; Baclofen; Bradykinin; Citric Acid; Cough; Dextromethorphan; Guinea Pigs

2012
Swallowing disorder and inhibition of cough reflex induced by atropine sulfate in conscious dogs.
    Journal of pharmacological sciences, 2008, Volume: 106, Issue:3

    Topics: Animals; Atropine; Baclofen; Cough; Deglutition Disorders; Dogs; Female; Male; Parasympatholytics; P

2008
Modulation of the cough reflex by antitussive agents within the caudal aspect of the nucleus tractus solitarii in the rabbit.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2008, Volume: 295, Issue:1

    Topics: Animals; Antitussive Agents; Baclofen; Cough; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-M

2008
Peripheral and central sites of action of GABA-B agonists to inhibit the cough reflex in the cat and guinea pig.
    British journal of pharmacology, 1994, Volume: 113, Issue:4

    Topics: Animals; Antitussive Agents; Baclofen; Capsaicin; Cats; Central Nervous System; Codeine; Cough; GABA

1994
Antitussive effects of GABAB agonists in the cat and guinea-pig.
    British journal of pharmacology, 1993, Volume: 110, Issue:1

    Topics: Animals; Antitussive Agents; Baclofen; Capsaicin; Cats; Codeine; Cough; Dextromethorphan; Electromyo

1993
Cough in patients with SCI.
    Physical therapy, 2000, Volume: 80, Issue:4

    Topics: Baclofen; Cough; GABA Agonists; Humans; Neck Injuries; Sensory Thresholds; Smoking; Spinal Cord Inju

2000
Baclofen-induced cough suppression in cervical spinal cord injury.
    Archives of physical medicine and rehabilitation, 2000, Volume: 81, Issue:7

    Topics: Adult; Baclofen; Cough; GABA Agonists; Humans; Male; Middle Aged; Prospective Studies; Reflex; Spina

2000
Effects of inhaled alpha 2-adrenoceptor and GABAB receptor agonists on citric acid-induced cough and tidal volume changes in guinea pigs.
    European journal of pharmacology, 1992, Sep-22, Volume: 220, Issue:2-3

    Topics: Acetylcholine; Administration, Inhalation; Adrenergic alpha-Agonists; Animals; Atropine; Azepines; B

1992
Baclofen therapy for intractable hiccoughs.
    Journal of clinical gastroenterology, 1990, Volume: 12, Issue:1

    Topics: Aged; Baclofen; Cough; Hiccup; Humans; Male

1990