baclofen has been researched along with Cough in 29 studies
Cough: A sudden, audible expulsion of air from the lungs through a partially closed glottis, preceded by inhalation. It is a protective response that serves to clear the trachea, bronchi, and/or lungs of irritants and secretions, or to prevent aspiration of foreign materials into the lungs.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To compare the efficacy of gabapentin and baclofen in patients with suspected refractory gastro-oesophageal reflux-induced chronic cough." | 9.30 | Randomised clinical trial: gabapentin vs baclofen in the treatment of suspected refractory gastro-oesophageal reflux-induced chronic cough. ( Chen, Q; Ding, H; Dong, R; Lv, H; Pan, J; Qiu, Z; Shi, C; Xu, X; Yu, L; Yu, Y; Zhang, M, 2019) |
| "To determine whether baclofen can suppress the cough induced by angiotensin-converting enzyme (ACE) inhibitors." | 9.08 | Use of baclofen to suppress cough induced by angiotensin-converting enzyme inhibitors. ( Dicpinigaitis, PV, 1996) |
| "Therapeutic efficacy of baclofen is suboptimal in the treatment of refractory gastroesophageal reflux-induced chronic cough (GERC)." | 8.02 | Pressure and length of the lower esophageal sphincter as predictive indicators of therapeutic efficacy of baclofen for refractory gastroesophageal reflux-induced chronic cough. ( Qiu, Z; Si, F; Sun, H; Xu, X; Yu, L; Zhang, M; Zhu, Y, 2021) |
| "To evaluate the efficacy and safety of baclofen for treatment of refractory gastroesophageal reflux-induced chronic cough (GERC) unresponsive to standard anti-reflux therapy." | 7.79 | Therapeutic efficacy of baclofen in refractory gastroesophageal reflux-induced chronic cough. ( Chen, Q; Liang, SW; Lv, HJ; Qiu, ZM; Xu, XH; Yang, ZM; Yu, L, 2013) |
| "In this study, the effects of atropine sulfate (atropine) on swallowing and cough reflex were evaluated in the two experimental models in conscious dogs." | 7.74 | Swallowing disorder and inhibition of cough reflex induced by atropine sulfate in conscious dogs. ( Katsura, Y; Mino, T; Seki, T; Sugimoto, S; Tsubouchi, T; Tsujimoto, S, 2008) |
| "To determine the effect of the GABA-agonist baclofen on cough reflex sensitivity in subjects with cervical spinal cord injury (C-SCI)." | 7.70 | Baclofen-induced cough suppression in cervical spinal cord injury. ( Dicpinigaitis, PV; Grimm, DR; Lesser, M, 2000) |
| " Cough responses to inhaled capsaicin were assessed at screening and 2h post-dose on each study day." | 5.41 | Effect of centrally and peripherally acting GABA ( Badri, H; Canning, BJ; Denton, D; Dockry, RJ; Escott, J; Holt, A; Holt, K; LGibbard, C; Satia, I; Smith, JA; Wilkinson, G, 2021) |
| "Cough was elicited by mechanical stimulation of the lumen of the intrathoracic trachea in spontaneously breathing cats." | 5.39 | Influence of baclofen on laryngeal and spinal motor drive during cough in the anesthetized cat. ( Castillo, D; Pitts, T, 2013) |
| "To compare the efficacy of gabapentin and baclofen in patients with suspected refractory gastro-oesophageal reflux-induced chronic cough." | 5.30 | Randomised clinical trial: gabapentin vs baclofen in the treatment of suspected refractory gastro-oesophageal reflux-induced chronic cough. ( Chen, Q; Ding, H; Dong, R; Lv, H; Pan, J; Qiu, Z; Shi, C; Xu, X; Yu, L; Yu, Y; Zhang, M, 2019) |
| " The GABA-agonist baclofen has been shown, in animal studies, to inhibit cough via a central mechanism, but has not been investigated in humans (to our knowledge)." | 5.08 | Antitussive effect of the GABA-agonist baclofen. ( Dicpinigaitis, PV; Dobkin, JB, 1997) |
| "The goal of this systematic review was to examine the evidence for the use of the neuromodulating agents, amitriptyline, gabapentin, pregabalin, and baclofen, in the management of chronic, idiopathic cough patients." | 4.89 | Use of specific neuromodulators in the treatment of chronic, idiopathic cough: a systematic review. ( Cohen, SM; Misono, S, 2013) |
| "Therapeutic efficacy of baclofen is suboptimal in the treatment of refractory gastroesophageal reflux-induced chronic cough (GERC)." | 4.02 | Pressure and length of the lower esophageal sphincter as predictive indicators of therapeutic efficacy of baclofen for refractory gastroesophageal reflux-induced chronic cough. ( Qiu, Z; Si, F; Sun, H; Xu, X; Yu, L; Zhang, M; Zhu, Y, 2021) |
| "Non-acid GERC had the similar cough character, cough symptom score, and capsaicin cough sensitivity to acid GERC." | 3.81 | Comparison of clinical characteristics of chronic cough due to non-acid and acid gastroesophageal reflux. ( Chen, Q; Liang, S; Lü, H; Qiu, Z; Xu, X; Yang, Z; Yu, L, 2015) |
| "To evaluate the efficacy and safety of baclofen for treatment of refractory gastroesophageal reflux-induced chronic cough (GERC) unresponsive to standard anti-reflux therapy." | 3.79 | Therapeutic efficacy of baclofen in refractory gastroesophageal reflux-induced chronic cough. ( Chen, Q; Liang, SW; Lv, HJ; Qiu, ZM; Xu, XH; Yang, ZM; Yu, L, 2013) |
| "We studied the influence of memantine on experimentally induced coughing in response to citric acid and bradykinin inhalation in guinea pigs." | 3.78 | Antitussive effects of memantine in guinea pigs. ( Canning, BJ; Hilton, ECY; Saulsberry, L; Smith, JA, 2012) |
| "In this study, the effects of atropine sulfate (atropine) on swallowing and cough reflex were evaluated in the two experimental models in conscious dogs." | 3.74 | Swallowing disorder and inhibition of cough reflex induced by atropine sulfate in conscious dogs. ( Katsura, Y; Mino, T; Seki, T; Sugimoto, S; Tsubouchi, T; Tsujimoto, S, 2008) |
| "To determine the effect of the GABA-agonist baclofen on cough reflex sensitivity in subjects with cervical spinal cord injury (C-SCI)." | 3.70 | Baclofen-induced cough suppression in cervical spinal cord injury. ( Dicpinigaitis, PV; Grimm, DR; Lesser, M, 2000) |
| "Chronic cough is a common symptom that can be difficult to treat." | 2.52 | NMDA and GABA receptors as potential targets in cough hypersensitivity syndrome. ( Chung, KF, 2015) |
| "Bicuculline and saclofen were microinjected into the rostral (rNTS) and caudal nucleus of the solitary tract (cNTS) in 17 anesthetized cats." | 1.91 | Differential inhibition of cough by GABA ( Cibulkova, L; Kotmanova, Z; Martvon, L; Poliacek, I; Simera, M; Veternik, M, 2023) |
| "Cough was elicited by mechanical stimulation of the lumen of the intrathoracic trachea in spontaneously breathing cats." | 1.39 | Influence of baclofen on laryngeal and spinal motor drive during cough in the anesthetized cat. ( Castillo, D; Pitts, T, 2013) |
| " Dose-response relationships for i." | 1.29 | Peripheral and central sites of action of GABA-B agonists to inhibit the cough reflex in the cat and guinea pig. ( Bolser, DC; Chapman, RW; DeGennaro, FC; Egan, RW; Hey, JA; Kreutner, W; O'Reilly, S, 1994) |
| "Cough is a prominent symptom of pulmonary disease, but the effects of GABAB agonists on this airway reflex are unknown." | 1.29 | Antitussive effects of GABAB agonists in the cat and guinea-pig. ( Aziz, SM; Bolser, DC; Chapman, RW; DeGennaro, FC; Egan, RW; Kreutner, W; Siegel, MI, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 9 (31.03) | 18.2507 |
| 2000's | 5 (17.24) | 29.6817 |
| 2010's | 11 (37.93) | 24.3611 |
| 2020's | 4 (13.79) | 2.80 |
| Authors | Studies |
|---|---|
| Badri, H | 1 |
| LGibbard, C | 1 |
| Denton, D | 1 |
| Satia, I | 1 |
| Dockry, RJ | 1 |
| Holt, K | 1 |
| Escott, J | 1 |
| Wilkinson, G | 1 |
| Holt, A | 1 |
| Canning, BJ | 2 |
| Smith, JA | 2 |
| Simera, M | 3 |
| Veternik, M | 3 |
| Martvon, L | 3 |
| Kotmanova, Z | 3 |
| Cibulkova, L | 1 |
| Poliacek, I | 3 |
| Dobrolubov, B | 1 |
| Babalova, L | 1 |
| Pitts, T | 3 |
| Jakus, J | 2 |
| Zhu, Y | 1 |
| Xu, X | 4 |
| Zhang, M | 2 |
| Si, F | 1 |
| Sun, H | 1 |
| Yu, L | 5 |
| Qiu, Z | 4 |
| Misek, J | 1 |
| Shen, TY | 1 |
| Musselwhite, MN | 1 |
| Bolser, DC | 4 |
| Dong, R | 2 |
| Ding, H | 1 |
| Pan, J | 1 |
| Yu, Y | 1 |
| Shi, C | 1 |
| Chen, Q | 3 |
| Lv, H | 1 |
| Naik, RD | 1 |
| Vaezi, MF | 1 |
| Castillo, D | 1 |
| Xu, XH | 1 |
| Yang, ZM | 1 |
| Liang, SW | 1 |
| Lv, HJ | 1 |
| Qiu, ZM | 1 |
| Yang, Z | 1 |
| Liang, S | 1 |
| Lü, H | 1 |
| Chung, KF | 1 |
| Mutolo, D | 2 |
| Bongianni, F | 2 |
| Cinelli, E | 2 |
| Pantaleo, T | 2 |
| Hilton, ECY | 1 |
| Saulsberry, L | 1 |
| Cohen, SM | 1 |
| Misono, S | 1 |
| Dykewicz, MS | 1 |
| Tsubouchi, T | 1 |
| Tsujimoto, S | 1 |
| Sugimoto, S | 1 |
| Katsura, Y | 1 |
| Mino, T | 1 |
| Seki, T | 1 |
| Fontana, GA | 1 |
| DeGennaro, FC | 2 |
| O'Reilly, S | 1 |
| Chapman, RW | 3 |
| Kreutner, W | 2 |
| Egan, RW | 2 |
| Hey, JA | 2 |
| Aziz, SM | 1 |
| Siegel, MI | 1 |
| Rizzo, CA | 1 |
| Dicpinigaitis, PV | 5 |
| Dobkin, JB | 2 |
| Rauf, K | 2 |
| Aldrich, TK | 1 |
| Beraldo, PS | 1 |
| Mateus, SR | 1 |
| Fernandes, MC | 1 |
| Grimm, DR | 1 |
| Lesser, M | 1 |
| Callaway, JK | 1 |
| King, RG | 1 |
| Bhalotra, R | 1 |
4 reviews available for baclofen and Cough
| Article | Year |
|---|---|
NMDA and GABA receptors as potential targets in cough hypersensitivity syndrome.
Topics: Animals; Antitussive Agents; Baclofen; Chronic Disease; Cough; GABA-B Receptor Agonists; Humans; Hyp | 2015 |
Use of specific neuromodulators in the treatment of chronic, idiopathic cough: a systematic review.
Topics: Amines; Amitriptyline; Baclofen; Chronic Disease; Cough; Cyclohexanecarboxylic Acids; Gabapentin; ga | 2013 |
Cough and angioedema from angiotensin-converting enzyme inhibitors: new insights into mechanisms and management.
Topics: Angioedema; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Anti-Asthmat | 2004 |
GABAB receptors in the lung.
Topics: Anaphylaxis; Animals; Baclofen; Cough; gamma-Aminobutyric Acid; Humans; Lung; Neurons, Afferent; Par | 1993 |
6 trials available for baclofen and Cough
| Article | Year |
|---|---|
Effect of centrally and peripherally acting GABA
Topics: Adult; Animals; Baclofen; Capsaicin; Cough; Double-Blind Method; Female; Humans; Reflex | 2021 |
Randomised clinical trial: gabapentin vs baclofen in the treatment of suspected refractory gastro-oesophageal reflux-induced chronic cough.
Topics: Adult; Analgesics; Baclofen; Chronic Disease; Cough; Dose-Response Relationship, Drug; Female; Follo | 2019 |
Use of baclofen to suppress cough induced by angiotensin-converting enzyme inhibitors.
Topics: Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Baclofen; Cough; Female; GABA Agonists; Human | 1996 |
Antitussive effect of the GABA-agonist baclofen.
Topics: Adult; Antitussive Agents; Baclofen; Capsaicin; Cough; Double-Blind Method; Female; GABA Agonists; H | 1997 |
Treatment of chronic, refractory cough with baclofen.
Topics: Administration, Oral; Adult; Aged; Baclofen; Bronchial Provocation Tests; Capsaicin; Chronic Disease | 1998 |
Inhibition of capsaicin-induced cough by the gamma-aminobutyric acid agonist baclofen.
Topics: Administration, Oral; Adult; Antitussive Agents; Baclofen; Capsaicin; Cough; Double-Blind Method; GA | 1998 |
19 other studies available for baclofen and Cough
| Article | Year |
|---|---|
Differential inhibition of cough by GABA
Topics: Animals; Baclofen; Bicuculline; Cats; Cough; GABA-B Receptor Antagonists; Microinjections; Solitary | 2023 |
Modulation of Cough Reflex by Gaba-Ergic Inhibition in Medullary Raphé of the Cat.
Topics: Animals; Baclofen; Cats; Cough; GABA-A Receptor Agonists; GABA-B Receptor Agonists; Medulla Oblongat | 2020 |
Pressure and length of the lower esophageal sphincter as predictive indicators of therapeutic efficacy of baclofen for refractory gastroesophageal reflux-induced chronic cough.
Topics: Baclofen; Chronic Disease; Cough; Esophageal Sphincter, Lower; Female; Gastroesophageal Reflux; Huma | 2021 |
GABA-ergic neurotransmission in the nucleus of the solitary tract modulates cough in the cat.
Topics: Animals; Baclofen; Blood Pressure; Cats; Cough; Esophagus; gamma-Aminobutyric Acid; Heart Rate; Inha | 2018 |
Editorial: breaking the cycle of cough in GERD-neuromodulators to the rescue? Authors' reply.
Topics: Baclofen; Cough; Gabapentin; Gastroesophageal Reflux; Humans; Neurotransmitter Agents | 2019 |
Editorial: breaking the cycle of cough in GERD-neuromodulators to the rescue?
Topics: Baclofen; Cough; Gabapentin; Gastroesophageal Reflux; Humans; Neurotransmitter Agents | 2019 |
Influence of baclofen on laryngeal and spinal motor drive during cough in the anesthetized cat.
Topics: Animals; Baclofen; Cats; Cough; Disease Models, Animal; Dose-Response Relationship, Drug; Electromyo | 2013 |
Therapeutic efficacy of baclofen in refractory gastroesophageal reflux-induced chronic cough.
Topics: Adult; Baclofen; Capsaicin; Cohort Studies; Cough; Domperidone; Esophageal pH Monitoring; Female; Ga | 2013 |
Comparison of clinical characteristics of chronic cough due to non-acid and acid gastroesophageal reflux.
Topics: Adult; Anti-Ulcer Agents; Baclofen; Capsaicin; Chronic Disease; Cough; Domperidone; Esophageal pH Mo | 2015 |
Depression of cough reflex by microinjections of antitussive agents into caudal ventral respiratory group of the rabbit.
Topics: Abdominal Muscles; Animals; Antitussive Agents; Baclofen; Cough; Diaphragm; Electromyography; Enkeph | 2010 |
Antitussive effects of memantine in guinea pigs.
Topics: Animals; Antitussive Agents; Baclofen; Bradykinin; Citric Acid; Cough; Dextromethorphan; Guinea Pigs | 2012 |
Swallowing disorder and inhibition of cough reflex induced by atropine sulfate in conscious dogs.
Topics: Animals; Atropine; Baclofen; Cough; Deglutition Disorders; Dogs; Female; Male; Parasympatholytics; P | 2008 |
Modulation of the cough reflex by antitussive agents within the caudal aspect of the nucleus tractus solitarii in the rabbit.
Topics: Animals; Antitussive Agents; Baclofen; Cough; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-M | 2008 |
Peripheral and central sites of action of GABA-B agonists to inhibit the cough reflex in the cat and guinea pig.
Topics: Animals; Antitussive Agents; Baclofen; Capsaicin; Cats; Central Nervous System; Codeine; Cough; GABA | 1994 |
Antitussive effects of GABAB agonists in the cat and guinea-pig.
Topics: Animals; Antitussive Agents; Baclofen; Capsaicin; Cats; Codeine; Cough; Dextromethorphan; Electromyo | 1993 |
Cough in patients with SCI.
Topics: Baclofen; Cough; GABA Agonists; Humans; Neck Injuries; Sensory Thresholds; Smoking; Spinal Cord Inju | 2000 |
Baclofen-induced cough suppression in cervical spinal cord injury.
Topics: Adult; Baclofen; Cough; GABA Agonists; Humans; Male; Middle Aged; Prospective Studies; Reflex; Spina | 2000 |
Effects of inhaled alpha 2-adrenoceptor and GABAB receptor agonists on citric acid-induced cough and tidal volume changes in guinea pigs.
Topics: Acetylcholine; Administration, Inhalation; Adrenergic alpha-Agonists; Animals; Atropine; Azepines; B | 1992 |
Baclofen therapy for intractable hiccoughs.
Topics: Aged; Baclofen; Cough; Hiccup; Humans; Male | 1990 |