Page last updated: 2024-10-23

aztreonam and Sepsis

aztreonam has been researched along with Sepsis in 40 studies

Aztreonam: A monocyclic beta-lactam antibiotic originally isolated from Chromobacterium violaceum. It is resistant to beta-lactamases and is used in gram-negative infections, especially of the meninges, bladder, and kidneys. It may cause a superinfection with gram-positive organisms.
aztreonam : A synthetic monocyclic beta-lactam antibiotic (monobactam), used primarily to treat infections caused by Gram-negative bacteria. It inhibits mucopeptide synthesis in the bacterial cell wall, thereby blocking peptidoglycan crosslinking.

Sepsis: Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.

Research Excerpts

ExcerptRelevanceReference
"Aztreonam was used in the initial treatment of infection of the urinary tract (23 cases), respiratory tract (17 cases), skin and soft tissue (12 cases), abdominal cavity (three cases), endocarditis (two cases), septicemia (eight cases), and osteomyelitis (two cases)."5.27Efficacy and safety of aztreonam in the treatment of serious gram-negative bacterial infections. ( Chandrasekar, P; Kannangara, W; LeFrock, JL; Molavi, A; Rolston, KV; Smith, BR, 1987)
"Two similar cohorts of low birth weight infants whose size was appropriate for gestational age randomly received either aztreonam-arginine plus ampicillin (n = 15) or gentamicin plus ampicillin (n = 15) for empiric treatment of neonatal sepsis."5.07Metabolic tolerance to arginine: implications for the safe use of arginine salt-aztreonam combination in the neonatal period. ( Argyle, C; McCracken, G; Mize, C; Uauy, R, 1991)
"Multicenter trials were conducted to determine the safety and efficacy of aztreonam in the treatment of patients with gram-negative bacterial infections."5.05Aztreonam: worldwide overview of the treatment of patients with gram-negative infections. ( Bendush, CB; Henry, SA, 1985)
" An adequate standard dosage of aztreonam could be established as 3-4 g/day in compromised patients, and it should be combined with gram-positive coverage when used empirically."2.66A multicenter comparative trial of aztreonam in the treatment of gram-negative infections in compromised intensive-care patients. ( Bosch-Perez, A; Rabinad, E, 1989)
"Aztreonam-treated patients are free of nephrotoxicity but are at risk of enterococcal superinfections."2.66Comparative clinical evaluation of aztreonam versus aminoglycosides in gram-negative septicaemia. ( Ariza, X; Fernández-Viladrich, P; Gudiol, F; Liñares, J; Pallarés, R; Rufi, G, 1986)
"Aztreonam has proven to be effective, safe therapy for serious and life-threatening infections caused by multiresistant aerobic gram negative bacteria."2.37Aztreonam: the first monobactam. ( Neu, HC, 1988)
"In addition, combined treatments of bacterial infections should allow for a reduction in dosages of antibiotics while at the same time, achieving increased efficacy."1.28Potentiation by nonspecific immunostimulation of the efficacy of antibiotics in the treatment of experimental bacterial infections. ( Bizzini, B; Fattal-German, M, 1989)
"Aztreonam was administered to 25 neonates (16 term, 9 premature) with clinically and bacteriologically proved gram-negative infections."1.28Successful response of severe neonatal gram-negative infection to treatment with aztreonam. ( Constantopoulos, A; Loupa, H; Papoulias, G; Thomaidou, L, 1989)
"Aztreonam was used for a year to treat 106 hospitalized patients with a total of 131 documented gram-negative infections."1.27Treatment of serious gram-negative infections with aztreonam. ( Bollinger, M; Darji, TB; Greenberg, RN; Luppen, KL; McMillian, R; Noorani, AA; Reilly, PM; Wolk, SM, 1984)
"Carumonam is a new N-sulfo-beta-lactam antibiotic active against aerobic Gram-negative bacteria."1.27Clinical efficacy of carumonam. ( Blakemore, PH; Drabu, YJ; Mehtar, S, 1988)
"Aztreonam was given i."1.27Aztreonam in the treatment of serious gram-negative infections in the elderly. ( Deger, F; Douchamps, J; Freschi, E; Herchuelz, A; Nève, P; Thys, JP, 1988)
"Aztreonam may prove to be an effective alternative for the treatment of gram-negative septicemia, but superinfections should be carefully monitored."1.27Aztreonam treatment of gram-negative septicemia. ( Boelaert, J; Huyghens, L; Lauwers, S; Naessens, A; Pierard, D; Van Landuyt, HW, 1986)
"Aztreonam was used in the initial treatment of infection of the urinary tract (23 cases), respiratory tract (17 cases), skin and soft tissue (12 cases), abdominal cavity (three cases), endocarditis (two cases), septicemia (eight cases), and osteomyelitis (two cases)."1.27Efficacy and safety of aztreonam in the treatment of serious gram-negative bacterial infections. ( Chandrasekar, P; Kannangara, W; LeFrock, JL; Molavi, A; Rolston, KV; Smith, BR, 1987)
"Carumonam was intermediate between ceftazidime and aztreonam as to the activity against Pseudomonas aeruginosa."1.27Antibacterial properties of carumonam (Ro 17-2301, AMA-1080), a new sulfonated monocyclic beta-lactam antibiotic. ( Angehrn, P, 1985)
"Aztreonam is a novel antimicrobial agent belonging to the monobactam class of antibiotics."1.27Use of aztreonam in the treatment of serious infections due to multiresistant gram-negative organisms, including Pseudomonas aeruginosa. ( Neu, HC; Scully, BE, 1985)
"Aztreonam is a monocyclic beta-lactam antibiotic that inhibits aerobic gram-negative bacilli, including beta-lactamase-producing species."1.27Current state of infectious diseases--potential areas of directed therapy with aztreonam. ( Neu, HC, 1985)

Research

Studies (40)

TimeframeStudies, this research(%)All Research%
pre-199024 (60.00)18.7374
1990's6 (15.00)18.2507
2000's4 (10.00)29.6817
2010's0 (0.00)24.3611
2020's6 (15.00)2.80

Authors

AuthorsStudies
Yu, W1
Xiong, L1
Luo, Q1
Chen, Y1
Ji, J1
Ying, C1
Liu, Z1
Xiao, Y1
Zhang, L1
Zhen, S1
Shen, Y1
Zhang, T1
Wang, J2
Li, J1
Lin, Q1
Xiao, Z1
Zheng, Y1
Jiang, E1
Han, M1
Feng, S1
Lu, B1
Wang, B1
Pan, X1
Liu, C1
Jin, C1
Shi, Y1
Zhou, Y1
Sieswerda, E1
van den Brand, M1
van den Berg, RB1
Sträter, J1
Schouls, L1
van Dijk, K1
Budding, AE1
Miller, J1
Hall, B1
Wilson, K1
Cobian, J1
Falcone, M1
Daikos, GL1
Tiseo, G1
Bassoulis, D1
Giordano, C1
Galfo, V1
Leonildi, A1
Tagliaferri, E1
Barnini, S1
Sani, S1
Farcomeni, A1
Ghiadoni, L1
Menichetti, F1
Araoka, H1
Baba, M1
Tatsushima, K1
Takagi, S1
Matsuno, N1
Wake, A1
Taniguchi, S1
Yoneyama, A1
Sklavunu-Tsurutsoglu, S2
Gatzola-Karaveli, M2
Hatziioannidis, K1
Tsurutsoglu, G2
Machado, DP1
Nunes, FB1
Simões Pires, MG1
D'Avila, LC1
Leite, CE1
Ruschel, RE1
da Cunha, AA1
Saciura, VC1
Poloni, JA1
Lunardelli, A1
de Oliveira, JR1
Alves Filho, JC1
Cunha, FQ1
Dias, FS1
Poli de Figueiredo, CE1
Jaber, A1
Nong, M1
Thiagarajan, P1
San Joaquin, VH1
Stutman, HR2
Marks, MI2
Greenberg, RN1
Reilly, PM1
Luppen, KL1
McMillian, R1
Bollinger, M1
Wolk, SM1
Darji, TB1
Noorani, AA1
Toyama, K1
Yaguchi, M1
Mizoguchi, H1
Masuda, M1
Urabe, A1
Ikeda, Y1
Aoki, I1
Shinbo, T1
Togawa, A1
Hirashima, K1
Miura, Y1
Hirose, S1
Tsuruoka, N1
Omine, M1
Kamakura, M1
Saito, T1
Arimori, S1
Aoki, N1
Kuraishi, Y1
Hirai, H1
Asano, S1
Mori, M1
Shirai, T1
Muto, Y1
Takaku, F1
Mercer-Jones, MA1
Hadjiminas, DJ1
Heinzelmann, M1
Peyton, J1
Cook, M1
Cheadle, WG1
Gilad, J1
Borer, A1
Peled, N1
Riesenberg, K1
Tager, S1
Appelbaum, A1
Schlaeffer, F1
Sakata, Y1
Sawada, Y1
Kuroe, K1
Nakaji, S1
Takami, H1
Tsushima, K1
Saito, S1
Ogasawara, H1
Shinagawa, H1
Soma, N1
Wu, SW1
Dornbusch, K1
Göransson, E1
Ransjö, U1
Kronvall, G1
Uauy, R1
Mize, C1
Argyle, C1
McCracken, G1
Spencer, RC1
Taylor, AK1
Winfield, DA1
Bizzini, B1
Fattal-German, M1
Rabinad, E2
Bosch-Perez, A1
Constantopoulos, A1
Thomaidou, L1
Loupa, H1
Papoulias, G1
Farid, Z1
Girgis, NI1
Abu el Ella, AH1
el-Messidi, M1
Dessouki, A1
Woody, J1
Drabu, YJ1
Mehtar, S1
Blakemore, PH1
Neu, HC3
Mozzillo, N1
Formato, A1
Ottaviano, A1
Romano, A1
Craus, W1
Dalet, F1
del Río, G1
Deger, F1
Douchamps, J1
Freschi, E1
Thys, JP1
Nève, P1
Herchuelz, A1
Wood, MJ1
Smith, G1
Farrell, ID1
Hitoglu-Makedu, A1
Paradelis, AG1
Lagast, H1
Klastersky, J1
Kains, JP1
van der Auwera, P1
Meunier, F1
Woussen, F1
Thijs, JP1
Pierard, D1
Boelaert, J1
Van Landuyt, HW1
Naessens, A1
Huyghens, L1
Lauwers, S1
Gudiol, F1
Pallarés, R1
Ariza, X1
Fernández-Viladrich, P1
Rufi, G1
Liñares, J1
Chartrand, SA1
Tolentino, T1
Friedhoff, L1
LeFrock, JL1
Smith, BR1
Chandrasekar, P1
Rolston, KV1
Molavi, A1
Kannangara, W1
Henry, SA1
Bendush, CB1
Starr, SE1
Angehrn, P1
Scully, BE1

Reviews

3 reviews available for aztreonam and Sepsis

ArticleYear
Hospital-acquired brevundimonas vesicularis septicaemia following open-heart surgery: case report and literature review.
    Scandinavian journal of infectious diseases, 2000, Volume: 32, Issue:1

    Topics: Adult; Anti-Infective Agents; Aztreonam; Ciprofloxacin; Cross Infection; Female; Humans; Microbial S

2000
Aztreonam: the first monobactam.
    The Medical clinics of North America, 1988, Volume: 72, Issue:3

    Topics: Aztreonam; Bacterial Infections; Gram-Negative Bacteria; Humans; Respiratory Tract Infections; Sepsi

1988
Antimicrobial therapy of bacterial sepsis in the newborn infant.
    The Journal of pediatrics, 1985, Volume: 106, Issue:6

    Topics: Aminoglycosides; Ampicillin; Anti-Bacterial Agents; Aztreonam; Bacteria; Cephalosporins; Cross Infec

1985

Trials

9 trials available for aztreonam and Sepsis

ArticleYear
Effect of recombinant human granulocyte colony-stimulating factor on combination therapy with aztreonam and clindamycin for infections in neutropenic patients with hematologic diseases.
    Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases, 1996, Volume: 70, Issue:12

    Topics: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Aztreonam; Clindamycin; Drug Therapy, Com

1996
[A randomized controlled study on imipenem/cilastatin sodium in comparison to aztreonam + lincomycin in treating severe infections in patients with malignant tumors or hematological diseases].
    The Japanese journal of antibiotics, 1992, Volume: 45, Issue:8

    Topics: Adolescent; Adult; Aged; Aztreonam; Cilastatin; Drug Therapy, Combination; Female; Hematologic Disea

1992
Metabolic tolerance to arginine: implications for the safe use of arginine salt-aztreonam combination in the neonatal period.
    The Journal of pediatrics, 1991, Volume: 118, Issue:6

    Topics: Ammonia; Ampicillin; Analysis of Variance; Arginine; Aztreonam; Bilirubin; Blood Glucose; Cohort Stu

1991
A comparative efficacy and safety study of teicoplanin plus aztreonam versus gentamicin plus piperacillin in haematology oncology patients with clinically diagnosed septicaemia.
    British journal of haematology, 1990, Volume: 76 Suppl 2

    Topics: Adult; Anti-Bacterial Agents; Aztreonam; Bacteria; Drug Therapy, Combination; Female; Gentamicins; G

1990
A multicenter comparative trial of aztreonam in the treatment of gram-negative infections in compromised intensive-care patients.
    Chemotherapy, 1989, Volume: 35 Suppl 1

    Topics: Adult; Aged; Aged, 80 and over; Aminoglycosides; Anti-Bacterial Agents; Aztreonam; Bacterial Infecti

1989
Antibiotic prophylaxis in surgery ranked by patients' risk rates.
    Chemioterapia : international journal of the Mediterranean Society of Chemotherapy, 1987, Volume: 6, Issue:2 Suppl

    Topics: Aztreonam; Clindamycin; Clinical Trials as Topic; Drug Therapy, Combination; Female; Gentamicins; Hu

1987
Empiric antimicrobial therapy with aztreonam or ceftazidime in gram-negative septicemia.
    The American journal of medicine, 1986, May-30, Volume: 80, Issue:5C

    Topics: Adult; Aged; Aztreonam; Blood Bactericidal Activity; Ceftazidime; Enterobacteriaceae Infections; Fem

1986
Comparative clinical evaluation of aztreonam versus aminoglycosides in gram-negative septicaemia.
    The Journal of antimicrobial chemotherapy, 1986, Volume: 17, Issue:5

    Topics: Adult; Aged; Aminoglycosides; Anti-Bacterial Agents; Aztreonam; Female; Gram-Negative Bacteria; Huma

1986
Aztreonam: worldwide overview of the treatment of patients with gram-negative infections.
    The American journal of medicine, 1985, Feb-08, Volume: 78, Issue:2A

    Topics: Abdomen; Adult; Anti-Bacterial Agents; Arthritis, Infectious; Aztreonam; Bacterial Infections; Clini

1985

Other Studies

28 other studies available for aztreonam and Sepsis

ArticleYear
    Frontiers in cellular and infection microbiology, 2021, Volume: 11

    Topics: Anti-Bacterial Agents; Azabicyclo Compounds; Aztreonam; beta-Lactamases; Carbapenems; Ceftazidime; D

2021
Bloodstream infections due to Carbapenem-Resistant Enterobacteriaceae in hematological patients: assessment of risk factors for mortality and treatment options.
    Annals of clinical microbiology and antimicrobials, 2023, May-18, Volume: 22, Issue:1

    Topics: Anti-Bacterial Agents; Aztreonam; Carbapenem-Resistant Enterobacteriaceae; Ceftazidime; Drug Combina

2023
First case of bloodstream infection caused by NDM-positive Escherichia hermannii.
    BMC infectious diseases, 2023, May-25, Volume: 23, Issue:1

    Topics: Aged; Anti-Bacterial Agents; Aztreonam; beta-Lactamases; Humans; Male; Microbial Sensitivity Tests;

2023
Successful rescue treatment of sepsis due to a pandrug-resistant, NDM-producing Klebsiella pneumoniae using aztreonam powder for nebulizer solution as intravenous therapy in combination with ceftazidime/avibactam.
    The Journal of antimicrobial chemotherapy, 2020, 03-01, Volume: 75, Issue:3

    Topics: Anti-Bacterial Agents; Azabicyclo Compounds; Aztreonam; beta-Lactamases; Ceftazidime; Drug Combinati

2020
Impact of SEP-1 on broad-spectrum combination antibiotic therapy in the emergency department.
    The American journal of emergency medicine, 2020, Volume: 38, Issue:12

    Topics: Adult; Aged; Anti-Bacterial Agents; Aztreonam; beta-Lactams; Cefepime; Centers for Medicare and Medi

2020
Efficacy of Ceftazidime-avibactam Plus Aztreonam in Patients With Bloodstream Infections Caused by Metallo-β-lactamase-Producing Enterobacterales.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2021, 06-01, Volume: 72, Issue:11

    Topics: Anti-Bacterial Agents; Azabicyclo Compounds; Aztreonam; beta-Lactamases; Ceftazidime; Drug Combinati

2021
[Case of sepsis caused by multidrug-resistant neutropenic-phase Pseudomonas aeruginosa treated successfully with antibiotic combination therapy].
    Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases, 2008, Volume: 82, Issue:5

    Topics: Amikacin; Anti-Bacterial Agents; Aztreonam; Drug Resistance, Multiple; Drug Therapy, Combination; Hu

2008
Aztreonam treatment of neonatal sepsis.
    Journal of chemotherapy (Florence, Italy), 1989, Volume: 1, Issue:4 Suppl

    Topics: Anti-Bacterial Agents; Aztreonam; Birth Weight; Gram-Negative Bacterial Infections; Humans; Infant;

1989
Effects of beta-lactam antibiotics and L-arginine in the treatment of experimental sepsis in rats.
    International journal of antimicrobial agents, 2006, Volume: 28, Issue:5

    Topics: Animals; Arginine; Ascitic Fluid; Aztreonam; beta-Lactams; Ceftriaxone; Drug Therapy, Combination; I

2006
Transient neutrophilic thrombophagocytosis associated with Citrobacter freundii septicemia.
    Archives of pathology & laboratory medicine, 2006, Volume: 130, Issue:12

    Topics: Aged; Anti-Bacterial Agents; Aztreonam; Citrobacter freundii; Enterobacteriaceae Infections; Humans;

2006
Hemophilus influenzae type b meningitis in infant rabbits. Pathogenesis and therapy.
    American journal of diseases of children (1960), 1984, Volume: 138, Issue:5

    Topics: Animals; Anti-Bacterial Agents; Aztreonam; Disease Models, Animal; Haemophilus Infections; Half-Life

1984
Treatment of serious gram-negative infections with aztreonam.
    The Journal of infectious diseases, 1984, Volume: 150, Issue:5

    Topics: Adolescent; Adult; Aged; Anti-Bacterial Agents; Aztreonam; Bacterial Infections; Drug Evaluation; En

1984
Continuous antibiotic treatment for experimental abdominal sepsis: effects on organ inflammatory cytokine expression and neutrophil sequestration.
    The British journal of surgery, 1998, Volume: 85, Issue:3

    Topics: Animals; Anti-Bacterial Agents; Aztreonam; Cefoxitin; Cephamycins; Cytokines; Endotoxins; Interleuki

1998
Characterization of Klebsiella oxytoca septicaemia isolates resistant to aztreonam and cefuroxime.
    The Journal of antimicrobial chemotherapy, 1991, Volume: 28, Issue:3

    Topics: Aztreonam; beta-Lactamases; Cefuroxime; DNA, Bacterial; Drug Resistance, Microbial; Humans; Klebsiel

1991
Potentiation by nonspecific immunostimulation of the efficacy of antibiotics in the treatment of experimental bacterial infections.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 1989, Volume: 43, Issue:10

    Topics: Adjuvants, Immunologic; Ampicillin; Animals; Anti-Bacterial Agents; Aztreonam; Bacterial Infections;

1989
Successful response of severe neonatal gram-negative infection to treatment with aztreonam.
    Chemotherapy, 1989, Volume: 35 Suppl 1

    Topics: Aztreonam; Bacterial Infections; Gram-Negative Bacteria; Humans; Infant, Newborn; Infant, Premature,

1989
Aztreonam in the treatment of enteric fevers.
    Annals of tropical medicine and parasitology, 1987, Volume: 81, Issue:6

    Topics: Adolescent; Adult; Aztreonam; Child; Female; Humans; Male; Paratyphoid Fever; Salmonella paratyphi A

1987
Clinical efficacy of carumonam.
    Drugs under experimental and clinical research, 1988, Volume: 14, Issue:10

    Topics: Aged; Aged, 80 and over; Aztreonam; Bacterial Infections; Female; Gram-Negative Aerobic Bacteria; Hu

1988
[Aztreonam: prevention of bacteremia in urologic surgery in patients with urinary infection].
    Medicina clinica, 1988, Jan-23, Volume: 90, Issue:3

    Topics: Adult; Aged; Aztreonam; Female; Gram-Negative Bacteria; Humans; Male; Middle Aged; Postoperative Com

1988
Aztreonam in the treatment of serious gram-negative infections in the elderly.
    International journal of clinical pharmacology, therapy, and toxicology, 1988, Volume: 26, Issue:1

    Topics: Aged; Aged, 80 and over; Aztreonam; Bacterial Infections; Female; Gram-Negative Aerobic Bacteria; Hu

1988
Aztreonam for severe infections.
    Chemioterapia : international journal of the Mediterranean Society of Chemotherapy, 1987, Volume: 6, Issue:2 Suppl

    Topics: Aztreonam; Bacterial Infections; Female; Humans; Male; Middle Aged; Sepsis; Urinary Tract Infections

1987
Aztreonam in gram-negative infections in children.
    Chemioterapia : international journal of the Mediterranean Society of Chemotherapy, 1987, Volume: 6, Issue:2 Suppl

    Topics: Aztreonam; Bacterial Infections; Child; Child, Preschool; Female; Gram-Negative Bacteria; Humans; In

1987
Aztreonam treatment of gram-negative septicemia.
    Antimicrobial agents and chemotherapy, 1986, Volume: 29, Issue:2

    Topics: Adolescent; Adult; Aged; Aztreonam; Female; Gram-Negative Bacteria; Humans; Male; Middle Aged; Sepsi

1986
Aztreonam therapy for serious gram-negative infections in children.
    American journal of diseases of children (1960), 1986, Volume: 140, Issue:11

    Topics: Aztreonam; Bacteria, Aerobic; Bacterial Infections; Child, Preschool; Humans; Infant; Infant, Newbor

1986
Efficacy and safety of aztreonam in the treatment of serious gram-negative bacterial infections.
    Archives of internal medicine, 1987, Volume: 147, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Aztreonam; Bacterial Infections; Female; Gram-Negative Bacteria; Hum

1987
Antibacterial properties of carumonam (Ro 17-2301, AMA-1080), a new sulfonated monocyclic beta-lactam antibiotic.
    Chemotherapy, 1985, Volume: 31, Issue:6

    Topics: Animals; Anti-Bacterial Agents; Aztreonam; Bacteria; Enterobacteriaceae; Escherichia coli Infections

1985
Use of aztreonam in the treatment of serious infections due to multiresistant gram-negative organisms, including Pseudomonas aeruginosa.
    The American journal of medicine, 1985, Volume: 78, Issue:2

    Topics: Adolescent; Adult; Aged; Anti-Bacterial Agents; Arthritis, Infectious; Aztreonam; Bacterial Infectio

1985
Current state of infectious diseases--potential areas of directed therapy with aztreonam.
    The American journal of medicine, 1985, Feb-08, Volume: 78, Issue:2A

    Topics: Abdomen; Anti-Bacterial Agents; Arthritis, Infectious; Aztreonam; Bacterial Infections; Biliary Trac

1985