Page last updated: 2024-10-23

aztreonam and Cough

aztreonam has been researched along with Cough in 2 studies

Aztreonam: A monocyclic beta-lactam antibiotic originally isolated from Chromobacterium violaceum. It is resistant to beta-lactamases and is used in gram-negative infections, especially of the meninges, bladder, and kidneys. It may cause a superinfection with gram-positive organisms.
aztreonam : A synthetic monocyclic beta-lactam antibiotic (monobactam), used primarily to treat infections caused by Gram-negative bacteria. It inhibits mucopeptide synthesis in the bacterial cell wall, thereby blocking peptidoglycan crosslinking.

Cough: A sudden, audible expulsion of air from the lungs through a partially closed glottis, preceded by inhalation. It is a protective response that serves to clear the trachea, bronchi, and/or lungs of irritants and secretions, or to prevent aspiration of foreign materials into the lungs.

Research Excerpts

ExcerptRelevanceReference
"Baseline bronchitic symptoms predict response to inhaled aztreonam in bronchiectasis."7.96Inhaled aztreonam improves symptoms of cough and sputum production in patients with bronchiectasis: a ( Barker, AF; Chalmers, JD; Crichton, ML; Goeminne, P; Lonergan, M; Shoemark, A; Sibila, O, 2020)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's1 (50.00)24.3611
2020's1 (50.00)2.80

Authors

AuthorsStudies
Crichton, ML1
Lonergan, M1
Barker, AF2
Sibila, O1
Goeminne, P1
Shoemark, A1
Chalmers, JD1
O'Donnell, AE1
Flume, P1
Thompson, PJ1
Ruzi, JD1
de Gracia, J1
Boersma, WG1
De Soyza, A1
Shao, L1
Zhang, J1
Haas, L1
Lewis, SA1
Leitzinger, S1
Montgomery, AB1
McKevitt, MT1
Gossage, D1
Quittner, AL1
O'Riordan, TG1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Phase 3, Double-Blind, Multicenter, Randomized, Placebo-Controlled Trial Evaluating Repeated Courses of Aztreonam for Inhalation Solution in Subjects With Non-CF Bronchiectasis and Gram-Negative Endobronchial Infection[NCT01313624]Phase 3266 participants (Actual)Interventional2011-04-30Completed
A Phase 3, Double-Blind, Multicenter, Randomized, Placebo-Controlled Trial Evaluating Repeated Courses of Aztreonam for Inhalation Solution/Aztreonam 75 mg Powder and Solvent for Nebuliser Solution in Subjects With Non-CF Bronchiectasis and Gram-Negative [NCT01314716]Phase 3274 participants (Actual)Interventional2011-04-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change in QOL-B Respiratory Symptoms Score at Day 28

The mean (SD) change in the Respiratory Symptoms score on the Quality of Life Questionnaire-Bronchiectasis (QOL-B) was measured from baseline to the end of Course 1 (Day 28). The QOL-B respiratory symptoms score was transformed onto a scale of 0-100, with higher scores representing a better quality of life. (NCT01313624)
Timeframe: Baseline to Day 28

Interventionunits on a scale (Mean)
AZLI-AZLI7.4
Placebo-AZLI5.7

Change in QOL-B Respiratory Symptoms Score at Day 84

The mean (SD) change in the Respiratory Symptoms score on the QOL-B was measured from baseline to the end of Course 2 (Day 84). The QOL-B respiratory symptoms score was transformed onto a scale of 0-100, with higher scores representing a better quality of life. (NCT01313624)
Timeframe: Baseline to Day 84

Interventionunits on a scale (Mean)
AZLI-AZLI7.4
Placebo-AZLI4.7

Time to Protocol-Defined Exacerbation (PDE)

"Protocol-defined exacerbation was defined as an acute worsening of respiratory disease that triggered the initiation of a non-study antibiotic meeting at least 3 major criteria, or 2 major and at least 2 minor criteria.~Major Criteria: increased sputum production; increased discoloration of sputum; increased dyspnea; increased cough~Minor Criteria: fever (> 38º C) measured during clinic visit; increased malaise or fatigue; forced expiratory volume in 1 second (FEV1) (L) or forced vital capacity (FVC) decreased > 10% from baseline; new or increased hemoptysis" (NCT01313624)
Timeframe: Baseline to Day 112

Interventiondays (Median)
AZLI-AZLINA
Placebo-AZLI120

Change in QOL-B Respiratory Symptoms Score at Day 28

The mean (SD) change in the Respiratory Symptoms score on the Quality of Life Questionnaire-Bronchiectasis (QOL-B) was measured from baseline to the end of Course 1 (Day 28). The QOL-B respiratory symptoms score was transformed onto a scale of 0-100, with higher scores representing a better quality of life. (NCT01314716)
Timeframe: Baseline to Day 28

Interventionunits on a scale (Mean)
AZLI-AZLI8.2
Placebo-AZLI3.2

Change in QOL-B Respiratory Symptoms Score at Day 84

The mean (SD) change in the Respiratory Symptoms score on the QOL-B was measured from baseline to the end of Course 2 (Day 84). The QOL-B respiratory symptoms score was transformed onto a scale of 0-100, with higher scores representing a better quality of life. (NCT01314716)
Timeframe: Baseline to Day 84

Interventionunits on a scale (Mean)
AZLI-AZLI5.6
Placebo-AZLI3.9

Time to Protocol-Defined Exacerbation (PDE)

"Protocol-defined exacerbation was defined as an acute worsening of respiratory disease that triggered the initiation of a non-study antibiotic meeting at least 3 major criteria, or 2 major and at least 2 minor criteria.~Major Criteria: increased sputum production; increased discoloration of sputum; increased dyspnea; increased cough~Minor Criteria: fever (> 38º C) measured during clinic visit; increased malaise or fatigue; forced expiratory volume in 1 second (FEV1) (L) or forced vital capacity (FVC) decreased > 10% from baseline; new or increased hemoptysis" (NCT01314716)
Timeframe: Baseline to Day 112

Interventiondays (Median)
AZLI-AZLINA
Placebo-AZLINA

Trials

1 trial available for aztreonam and Cough

ArticleYear
Aztreonam for inhalation solution in patients with non-cystic fibrosis bronchiectasis (AIR-BX1 and AIR-BX2): two randomised double-blind, placebo-controlled phase 3 trials.
    The Lancet. Respiratory medicine, 2014, Volume: 2, Issue:9

    Topics: Administration, Inhalation; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Aztre

2014
Aztreonam for inhalation solution in patients with non-cystic fibrosis bronchiectasis (AIR-BX1 and AIR-BX2): two randomised double-blind, placebo-controlled phase 3 trials.
    The Lancet. Respiratory medicine, 2014, Volume: 2, Issue:9

    Topics: Administration, Inhalation; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Aztre

2014
Aztreonam for inhalation solution in patients with non-cystic fibrosis bronchiectasis (AIR-BX1 and AIR-BX2): two randomised double-blind, placebo-controlled phase 3 trials.
    The Lancet. Respiratory medicine, 2014, Volume: 2, Issue:9

    Topics: Administration, Inhalation; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Aztre

2014
Aztreonam for inhalation solution in patients with non-cystic fibrosis bronchiectasis (AIR-BX1 and AIR-BX2): two randomised double-blind, placebo-controlled phase 3 trials.
    The Lancet. Respiratory medicine, 2014, Volume: 2, Issue:9

    Topics: Administration, Inhalation; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Aztre

2014

Other Studies

1 other study available for aztreonam and Cough

ArticleYear
Inhaled aztreonam improves symptoms of cough and sputum production in patients with bronchiectasis: a
    The European respiratory journal, 2020, Volume: 56, Issue:1

    Topics: Administration, Inhalation; Anti-Bacterial Agents; Aztreonam; Bronchiectasis; Cough; Humans; Quality

2020