azomycin has been researched along with Hypoxia in 289 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 67 (23.18) | 18.7374 |
| 1990's | 27 (9.34) | 18.2507 |
| 2000's | 81 (28.03) | 29.6817 |
| 2010's | 96 (33.22) | 24.3611 |
| 2020's | 18 (6.23) | 2.80 |
| Authors | Studies |
|---|---|
| Abuteen, A; Dietz, C; Mohammad, I; Smith, MB; Zanganeh, S; Zhou, F; Zhu, Q | 1 |
| Kumar, P; Mannan, RH; McEwan, AJ; Wiebe, LI; Xia, H; Zhang, Z | 1 |
| Angermeier, A; Della Manna, D; Larimer, BM; Li, Y; Reeves, KM; Song, PN; Sorace, AG; Wang, J; Yang, ES | 1 |
| Deep, G; Kim, S; Kumar, D; Rios-Colon, L; Su, Y | 1 |
| Diaz-Dussan, D; El-Saidi, H; Ismail, IH; Kumar, P; Macdonald, D; Mashayekhi, F; Narain, R; Nation, PN; Rashed, FB; Ricardo, C; Sokhi, S; Stoica, AC; Weinfeld, M; Wiebe, LI; Yang, XH | 1 |
| de Bree, R; H A M Kaanders, J; Philippens, MEP; Smits, HJG; Swartz, JE; Willems, SM | 1 |
| Bresser, PL; Sathekge, MM; Vorster, M | 1 |
| Hu, F; Li, Y; Ma, M; Meng, T; Shang, X; Shi, K; Tian, Y; Yuan, H | 1 |
| Luo, J; Mu, X; Wang, Z; Yang, Q; Zhao, Y | 1 |
| Bruce, J; Cairns, R; Chaudary, N; Croke, J; D'Souza, D; Dhani, N; Fyles, A; Han, K; Jaffray, D; Koritzinsky, M; Lee, TY; Metser, U; Milosevic, M; Pakbaz, S; Pintilie, M; Rouzbahman, M; Shek, T; Vines, D | 1 |
| Labiano, S; Rodriguez-Ruiz, ME; Serrano-Mendioroz, I | 1 |
| Li, Y; Liu, M; Wang, Z; Zhao, Y; Zheng, Y | 1 |
| Hay, MP; Hicks, KO; Hong, CR; Jamieson, SMF; Liew, LP; Shome, A; Wong, WW | 1 |
| Cheng, W; Jia, T; Miao, R; Shao, J; Zeng, L; Zhang, C; Zhang, J; Zhao, Y; Zhu, H | 1 |
| Mallia, MB; Mittal, S | 1 |
| Fukatsu, A; Inada, A | 1 |
| Arias, SCA; Ávila, VF; Câmara, NOS; Fanelli, C; Faustino, VD; Foresto-Neto, O; Fujihara, CK; Malheiros, DMAC; Moreira, GCDS; Nascimento, TF; Rempel, LCT; Zatz, R | 1 |
| Fan, B; Hu, M; Ma, L; Mu, D; Yang, G; Yu, J; Zhao, S; Zheng, J; Zhu, Y | 1 |
| Hansen, CR; Johansen, J; Kallehauge, J; Mortensen, LS; Overgaard, J; Primdahl, H; Saksø, M | 1 |
| Abdalah, MA; Budzevich, MM; Bui, MM; Dominguez-Viqueira, W; Gillies, RJ; Huang, S; Jardim-Perassi, BV; Johnson, JO; Martinez, GV; Mu, W; Poleszczuk, J; Reed, DR; Tomaszewski, MR | 1 |
| Dimitrakopoulou, A; Giannouli, S; Kambas, K; Katsila, T; Kloukina, I; Mouchtouris, V; Pagakis, SN; Patrinos, GP; Poulaki, A; Probert, L; Ritis, K; Stergiou, IE; Tzioufas, AG; Vidali, V; Voulgarelis, M; Xingi, E | 1 |
| Elias, AA; Maki, Y; Matushewski, B; Nygard, K; Regnault, TRH; Richardson, BS | 1 |
| Asada, Y; Iwakiri, T; Kawai, K; Kitamura, K; Koshimoto, C; Kuge, Y; Matsuura, Y; Sugita, C; Tamaki, N; Yamasaki, K; Yamashita, A; Zhao, S; Zhao, Y | 1 |
| Endo, Y; Goto-Koshino, Y; Lai, YC; Miura, N; Nakaichi, M; Setoguchi, A; Tateno, M; Tsujimoto, H; Yamazaki, H | 1 |
| Andersen, LMK; Galappathi, K; Gaustad, JV; Hauge, A; Rofstad, EK; Simonsen, TG; Wegner, CS | 1 |
| Hart, CP; Kishimoto, S; Krishna, MC; Matsumoto, S; Mitchell, JB; Naz, S; Saito, K; Takakusagi, Y | 1 |
| Jayagopal, A; McCollum, GW; Penn, JS; Uddin, MI; Yang, R | 1 |
| Heffern, MC; Stevenson, MJ | 1 |
| Cai, K; Chen, Y; He, H; Sun, W; Yin, L; Zhu, R | 1 |
| Bayin, NS; Placantonakis, DG | 1 |
| Brenner, A; Caflisch, L; Cavazos, D; Fichtel, L; Floyd, J; Gruslova, A; Hart, CP; Huang, S; Kroll, S; Liu, Y; Lodi, A; Sun, JD; Tiziani, S; Zuniga, R | 1 |
| Gendoo, DMA; Haibe-Kains, B; Haller, A; Haynes, J; Jaffray, DA; Kreso, A; Leung, C; Lima-Fernandes, E; McKee, TD; Metser, U; O'Brien, CA; Smith, M; Szentgyorgyi, E; Vines, DC; Wang, Y; Wolman, R; Wouters, BG | 1 |
| He, X; Huang, Y; Liu, L; Tian, Y; Xue, C; Zhan, J; Zhang, L; Zhao, Y | 1 |
| Kuge, Y; Matsumoto, H; Nishijima, KI; Ogawa, M; Shiga, T; Shimizu, Y; Tamaki, N; Yasui, H; Zhao, S | 1 |
| Guo, X; Huang, X; Wang, B; Wang, L; Wang, Z; Zhao, J; Zhao, Y | 1 |
| Ding, JS; Yang, YJ | 1 |
| Adam, ASA; Boulghourjian, A; Caldon, CE; Cazet, AS; Conway, JRW; Croucher, DR; Da Silva, AM; Del Monte-Nieto, G; Haigh, JJ; Harvey, RP; Herrmann, D; Killen, MJ; Magenau, A; Mélénec, P; Morton, JP; Murphy, KJ; Nobis, M; Pajic, M; Pinese, M; Sansom, OJ; Shearer, RF; Timpson, P; Vennin, C; Wang, Y; Warren, SC; Zaratzian, A | 1 |
| Shimizu, Y | 1 |
| Hicks, KO; Hong, CR; Wilson, WR | 1 |
| Cheng, GJ; Hay, MP; Jamieson, SMF; Liew, LP; Singleton, DC; Wong, WW | 1 |
| Cao, J; Hong, H; Kung, HF; Liu, Y; Qiao, J; Yao, X; Zha, Z; Zhang, A; Zhang, L; Zhang, Y; Zhao, R; Zhu, L | 1 |
| Fattorini, L; Giannoni, F; Iacobino, A; Pardini, M; Piccaro, G | 1 |
| Aminuddin, A; Fujisaka, S; Goda, N; Ikutani, M; Mahmood, A; Nagai, Y; Takatsu, K; Takikawa, A; Tobe, K; Tsuneyama, K; Usui, I | 1 |
| Ababneh, DH; Oakes, DJ; Power, CA; Ritchie, HE; Webster, WS | 1 |
| Azzouz, R; Bischoff, L; Bohn, P; Bol, A; Bol, V; Grégoire, V; Joyard, Y; Labar, D; Levacher, V; Papamicaël, C; Vera, P | 1 |
| Aguirre, A; Kuhn, L; Mohammad, I; Smith, MB; Wang, T; Xu, Y; Yang, Y; Zanganeh, S; Zhu, Q | 1 |
| Busk, M; Horsman, MR; Iversen, AB; Jakobsen, S; Ji, X; Lee, DY; Mortensen, LS; Nordsmark, M; Overgaard, J; Raleigh, JR | 1 |
| Alterio, V; De Simone, G; Dubois, L; Lambin, P; Monti, SM; Parvathaneni, NK; Rami, M; Supuran, CT; van Kuijk, SJ; Winum, JY | 1 |
| Gupta, AK; Kumar, P; Ortlieb, R; Wiebe, LI | 1 |
| Capozzi, ME; Craft, JR; Evans, SM; Jayagopal, A; Kim, K; Moore, CE; Sulikowski, GA; Uddin, MI | 1 |
| Beppu, T; Ehara, S; Iwata, R; Mtsuura, H; Ogasawara, K; Sasaki, M; Sasaki, T; Saura, H; Takai, Y; Terasaki, K | 1 |
| Andreeff, M; Benito, J; Borthakur, G; Bueso-Ramos, C; Cortes, J; Coveler, A; Daver, N; Estey, EH; Faderl, S; Feliu, J; Gu, Y; Gutheil, JC; Jabbour, E; Kadia, T; Kantarjian, H; Konoplev, S; Konopleva, M; Kornblau, S; Lu, H; Melink, TJ; Nguyen, HQ; Pemmaraju, N; Ravandi, F; Thall, PF; Thomas, D; Wei, C; Wilson, WR; Yi, CA | 1 |
| Duan, X; Li, J; Li, XF; Ma, Y; Postel, GC; Wang, F; Wang, X; Yin, X; Zhang, G; Zheng, H | 1 |
| Betts, HM; Dutton, D; Perkins, AC; Turton, DR | 1 |
| Beppu, T; Kobayashi, M; Ogasawara, K; Ogawa, A; Saura, H; Takai, Y; Terasaki, K; Yoshida, K | 1 |
| Chae, JR; Cho, A; Cho, YL; Chung, KY; Kang, WJ; Kim, JY; Lee, JW; Park, SY | 1 |
| Mönnich, D; Thorwarth, D; Troost, EG; van Elmpt, W; Wack, LJ; Zegers, CM; Zips, D | 1 |
| Bollineni, VR; Bruine de Bruin, L; de Bock, GH; Halmos, GB; Langendijk, JA; Pruim, J; Schuuring, E; Slagter-Menkema, L; Steenbakkers, RJ; van der Laan, BF; van der Wal, JE; van Hemel, BM; Wachters, JE | 1 |
| Ahmad, Z; Chen, X; Lv, S; Shah, A; Tang, Z | 1 |
| Andreeff, M; Bankson, JA; Benito, J; Bhattacharya, PK; Cortes, JE; Davis, RE; Hart, CP; Harutyunyan, KG; Jacamo, R; Konoplev, S; Konopleva, M; Lee, J; Lu, H; Ma, H; Marszalek, JR; Matre, P; McQueen, T; Millward, NZ; Mu, H; Protopopova, M; Ramirez, MS; Shi, YX; Velez, J; Volgin, A | 1 |
| Banka, VK; Chung, JK; Hong, MK; Jeong, JM; Kim, YJ; Lee, DS; Lee, JY; Lee, YS; Seelam, SR | 1 |
| Bahce, I; Boellaard, R; de Langen, AJ; Hoekstra, OS; Huisman, MC; Iqbal, R; Kramer, GM; Lammertsma, AA; van Velden, FH; Verwer, EE; Windhorst, AD | 1 |
| Chu, T; Huang, H; Zhang, Q | 1 |
| Yoshimoto, M | 1 |
| Dhani, NC; Green, D; Hedley, DW; Jaffray, D; Metran-Nascente, C; Metser, U; Milosevic, M; Vines, DC; Yeung, I | 1 |
| Bar-Sagi, D; Grabocka, E; Mishra, B; Sundstrom, A | 1 |
| Andreeff, M; Badar, T; Benito, JM; Borthakur, G; Cortes, JE; Faderl, S; Handisides, DR; Harutyunyan, K; Jabbour, E; Kantarjian, HM; Konoplev, S; Konopleva, M; Kroll, S; Pearce, T; Richie, MA; Thomas, DA | 1 |
| Baker, AF; Cornnell, HH; Gillies, R; Hart, CP; Martinez, GV; Wojtkowiak, JW; Zhang, X | 1 |
| Fourcade, O; Geeraerts, T; Gonzalez, L; Kerhuel, L; Luzi, A; Mrozek, S | 1 |
| Hu, X; Huang, Y; Wang, S; Wei, Y; Yu, J; Yu, Q; Yuan, S; Zhao, S; Zhao, W; Zhu, S | 1 |
| Baumann, M; Mönnich, D; Thorwarth, D; Wack, LJ; Yaromina, A; Zips, D | 1 |
| Ham, SL; Joshi, R; Luker, GD; Tavana, H | 1 |
| He, T; Xing, Y; Yang, N; Zhang, W | 1 |
| Crukley, C; Desjardins, L; Hadway, J; Lee, TY; Morrison, L; Stewart, E; Wang, Y | 1 |
| Brader, P; Carlin, S; Chun, YS; Fong, Y; Hricak, H; Ling, CC; Riedl, CC; Singh, P; Wen, B; Woo, Y; Zanzonico, PB | 1 |
| Cheguillaume, A; De Bast, M; de Groot, T; Gillart, J; Grégoire, V; Haustermans, K; Labar, D; Mahy, P | 1 |
| Busk, M; Bussink, J; Horsman, MR; Jakobsen, S; Overgaard, J; van der Kogel, A | 1 |
| Bol, A; Bormans, G; Cloetens, L; Dubois, L; Grégoire, V; Haustermans, K; Labar, D; Landuyt, W; Mortelmans, L; Nuyts, J | 1 |
| Banerjee, S; Mallia, MB; Mathur, A; Sarma, HD; Subramanian, S; Venkatesh, M | 2 |
| Boerman, OC; Bussink, J; Kaanders, JH; Laverman, P; Oyen, WJ; Troost, EG | 1 |
| Gilbert, RE; Kelly, DJ; Langham, RG; Tiauw, V; Wiggins, KJ; Zhang, Y | 1 |
| Cui, P; Dai, M; Han, J; Li, H; Liu, Q; Xiu, R; Yu, M; Zhang, J | 1 |
| Cui, P; Dai, M; Han, J; Li, H; Liu, Q; Xiu, R; Yu, M | 1 |
| Chu, T; Li, Z; Wang, X | 1 |
| Heyman, SN; Paliege, A; Rosen, S; Rosenberger, C | 1 |
| Batmunkh, E; Hori, H; Miyake, K; Nagasawa, H; Nishioka, M; Shimada, M; Sugimoto, K; Uto, Y | 1 |
| Fujibayashi, Y; Fujieda, S; Furukawa, T; Kobayashi, M; Kudo, T; Mori, T; Oh, M; Tanaka, T | 1 |
| Abrams, DN; Kumar, P; McEwan, AJ; Postema, EJ; Riauka, TA; Richmond, DA; Wiebe, LI | 1 |
| Boutrid, H; Cebulla, CM; Feuer, WJ; Jockovich, ME; Lampidis, TJ; Murray, TG; Piña, Y | 1 |
| Baumann, M; Eckardt, A; Eicheler, W; Schuetze, C; Thames, H; Yaromina, A; Zips, D | 1 |
| Cho, H; Koutcher, JA; Li, XF; Ling, CC; Lupu, ME; Russell, J; Yang, KM | 1 |
| Busk, M; Bussink, J; Hansen, KV; Horsman, MR; Jakobsen, S; Overgaard, J; van der Kogel, A | 1 |
| Baumann, M; Meyer, S; Mueller-Klieser, W; Quennet, V; Shakirin, G; Walenta, S; Yaromina, A; Zips, D | 1 |
| Bayly, SR; Betts, HM; Bonnitcha, PD; Dilworth, JR; Lewis, JS; Theobald, MB | 1 |
| Möller, A; Young, RJ | 1 |
| McPhail, LD; Robinson, SP | 1 |
| Anderson, RF; Denny, WA; Franzblau, SG; Ma, Z; Maroz, A; Palmer, BD; Shinde, SS | 1 |
| Bengtsson, E; Blomgren, B; Danielsson, BR; Danielsson, C; Johansson, A; Khan, KM; Kultima, K; Nilsson, MF; Sköld, AC; Webster, WS; Wilson, J | 1 |
| Kumar, P; McEwan, AJ; Naimi, E; Wiebe, LI | 1 |
| Bol, A; Christian, N; De Bast, M; Deheneffe, S; Grégoire, V; Labar, D; Lee, JA | 1 |
| Humm, JL; Li, XF; Ling, CC; Ma, Y; O'Donoghue, JA; Sun, X | 1 |
| De Raeve, H; Handisides, DR; Hart, CP; Hu, J; Liu, Q; Menu, E; Sun, JD; Van Camp, B; Van Valckenborgh, E; Vande Broek, I; Vanderkerken, K | 1 |
| Boerman, OC; Bussink, J; Franssen, GM; Hoeben, BA; Kaanders, JH; Oosterwijk, E; Oyen, WJ; Rijken, PF; Troost, EG; van Dongen, GA | 1 |
| Baumann, M; Beuthien-Baumann, B; Bussink, J; Eicheler, W; Krause, M; Rijken, P; Santiago, A; van der Kogel, AJ; Yaromina, A | 1 |
| Boutrid, H; Celdran, M; Feuer, W; Hernandez, E; Houston, SK; Lampidis, TJ; Murray, TG; Piña, Y; Shi, W | 1 |
| Babaev, AA; Golubiatnikov, GY; Ivanova, IP; Kamensky, VA; Maslennikova, AV; Orlova, AG; Plekhanov, VI; Prianikova, TI; Shakhova, NM; Snopova, LB; Turchin, IV | 1 |
| Gorodkin, R; Herrick, AL; Jeziorska, M; Stratford, IJ | 1 |
| Batlle, D; Cabray, J; Halter, S; Li, LP; Prasad, P; Ye, M | 1 |
| Busk, M; Horsman, MR; Jakobsen, S; Munk, OL; Overgaard, J; Skals, M; Steiniche, T; Wang, T | 1 |
| Alpaugh, K; Bélanger, MJ; Doss, M; Hostetler, ED; Kolb, HC; Stubbs, JB; Yu, JQ; Zhang, JJ | 1 |
| Jung, HJ; Kim, KH; Kwon, HJ; Park, JY | 1 |
| Chitneni, SK; Dewhirst, MW; Palmer, GM; Zalutsky, MR | 1 |
| Carreau, A; El Hafny-Rahbi, B; Grillon, C; Kieda, C; Matejuk, A | 1 |
| Alsner, J; Busk, M; Horsman, MR; Jakobsen, S; Overgaard, J; Sørensen, BS; Toustrup, K | 1 |
| Chaudhuri, S; Hennings, L; Hinson, JA; James, LP; Letzig, L; McCullough, SS; Simpson, PM | 1 |
| Forsback, S; Heinonen, SE; Knuuti, J; Laine, VJ; Roivainen, A; Saraste, A; Saukko, P; Silvola, JM; Ylä-Herttuala, S | 1 |
| Liu, K; Zhu, HL | 1 |
| Cabrera, AR; Fu, Z; Ma, L; Sun, X; Xie, P; Yang, Y; Yu, J; Yue, J; Zhao, S; Zheng, J | 1 |
| Bifani, P; Dartois, V; Heng, Y; Hervé, M; Kiass, M; Mathys, V; Seah, PG; Siew, JY; Singhal, A; Tay, HC | 1 |
| Combes, V; Grau, GE; Hempel, C; Hunt, NH; Kurtzhals, JA | 1 |
| Hammerschmidt, F; Schweifer, A | 1 |
| Cai, X; Duan, JX; Jiao, H; Jung, D; Lin, L; Matteucci, M | 1 |
| Hagtvet, E; Olsen, DR; Røe, K | 1 |
| Bukala, D; Cay, F; Judenhofer, MS; Kneilling, M; Machulla, HJ; Maier, FC; Pichler, BJ; Reischl, G; Röcken, M; Schmid, A | 1 |
| Chu, T; Huang, H; Li, Z; Wang, X; Zhou, H | 1 |
| Bishai, WR; Davis, SL; Harper, J; Jain, SK; Kramnik, I; Nuermberger, EL; Pomper, MG; Skerry, C; Tasneen, R; Weir, M | 1 |
| Griffin, RJ; Koonce, NA; Przybyla, BD; Shafirstein, G; Webber, JS | 1 |
| Barber, PR; Bell, A; Burke, M; Daley, FM; Finch, J; Goh, V; Hoskin, PJ; Kozarski, R; Mandeville, HC; Ng, QS; Pierce, G; Townsend, ER; Vojnovic, B | 1 |
| Carlin, S; Humm, JL | 1 |
| Barranger, E; Barré, E; Baruch-Hennequin, V; Delord, M; Delpech, Y; Groheux, D; Hindié, E; Homyrda, L; Schlageter, MH; Thoury, A; Tylski, P; Vercellino, L; Walker, F | 1 |
| Bussink, J; Grénman, R; Iida, M; Kaanders, JH; Span, PN; Stegeman, H; van der Kogel, AJ; Verheijen, MM; Waaijer, SJ; Wheeler, DL | 1 |
| Busk, M; D'Andrea, FP; Hansen, KV; Horsman, MR; Jakobsen, S; Kallehauge, JF; Mortensen, LS; Nordsmark, M; Overgaard, J; Steiniche, T; Theil, J | 1 |
| Bachmann, S; Dietrich, A; Kaminski, H; Mathia, S; Mrowka, R; Mutig, K; Paliege, A; Rosenberger, C | 1 |
| Kertscho, H; Lauscher, P; Meier, J; Rosenberger, P; Schmidt, O; Zacharowski, K; Zimmermann, R | 1 |
| Grimshaw, R; Honess, DJ; Maxwell, RJ; Raynaud, F; Seddon, BM; Tozer, GM; Workman, P | 1 |
| Basile, DP; Donohoe, DL; Mattson, DL; Roethe, K | 1 |
| Asikoglu, M; Kumar, P; McEwan, AJ; Tandon, M; Wiebe, LI | 1 |
| Balm, AJ; Begg, AC; Blijweert, E; Blommestijn, G; Delaere, P; Haustermans, KM; Hoebers, FJ; Hofland, I; Janssen, HL; Raleigh, JA; Sciot, R; Semenza, GL; Sprong, D; van Velthuysen, ML; Varia, MA | 1 |
| Ashino, H; Hazato, T; Hori, H; Inayama, S; Nagasawa, H; Shimamura, M; Uto, Y; Yamamoto, Y | 1 |
| Bachmann, S; Eckardt, KU; Frei, U; Griethe, W; Gruber, G; Rosenberger, C; Wiesener, M | 1 |
| Azuma, Y; Chou, SC; Lininger, RA; Murphy, BJ; Raleigh, JA; Varia, MA | 1 |
| Grimshaw, R; Halbert, G; Judson, I; Leach, MO; Payne, GS; Raynaud, F; Ruddle, R; Seddon, BM; Simmons, L; Tan, S; Turner, A; Workman, P | 1 |
| Frischer, JS; Holash, J; Huang, J; Kadenhe-Chiwishe, A; Kandel, JJ; Kim, ES; Lee, A; New, T; Pollyea, DA; Serur, A; Yamashiro, DJ; Yancopoulos, GD; Yokoi, A | 1 |
| Balm, AJ; Begg, AC; Goethals, L; Haustermans, KM; Hoebers, FJ; Janssen, HL; Sprong, D; Stratford, IJ; Williams, KJ | 1 |
| Hatta, H; Kojima, R; Nishimoto, S; Tanabe, K | 1 |
| Griffiths, JR; Robinson, SP | 1 |
| Seddon, BM; Workman, P | 1 |
| Davidson, SE; Harris, AL; Hunter, RD; Hutchison, GJ; Loncaster, JA; Price, PM; Roberts, SA; Stratford, IJ; Valentine, HR; West, CM | 1 |
| Adomat, H; Bowden, M; Dragowska, W; Gleave, M; Koch, CJ; Skov, K; Woo, J; Yapp, DT | 1 |
| Amin, K; Arcasoy, MO; Chou, SC; Haroon, ZA; Raleigh, JA; Varia, M | 1 |
| Funaki, Y; Furumoto, S; Hakamatsuka, T; Ishikawa, Y; Iwata, R; Kaneta, T; Kudo, Y; Nakata, E; Takai, Y; Yamada, S | 1 |
| Fitzmaurice, RJ; Lunt, SJ; Stratford, IJ; Telfer, BA; Williams, KJ | 1 |
| Doege, K; Heine, S; Jelkmann, W; Jensen, I; Metzen, E | 1 |
| Asosingh, K; De Raeve, H; de Ridder, M; Storme, GA; Van Camp, B; Van Riet, I; Vanderkerken, K; Willems, A | 1 |
| Binns, D; Cullinane, C; Hicks, RJ; McArthur, GA; Roselt, P; Solomon, B; Weibe, LI | 1 |
| Céspedes, C; Villanueva, S; Vio, CP | 1 |
| Parker, CA; Stratford, IJ; Williams, KJ | 1 |
| Bernhardt, W; Eckardt, KU; Frei, U; Heyman, SN; Rosen, S; Rosenberger, C; Shina, A; Wiesener, MS | 1 |
| Banerjee, S; Mallia, MB; Sarma, HD; Subramanian, S; Venkatesh, M | 1 |
| Aly, S; Bange, FC; Brandau, S; Ehlers, S; Keller, C; Malm, S; Malzan, A; Wagner, K | 1 |
| Curtis, TM; de Gooyer, TE; Gardiner, TA; Humphries, P; Simpson, DA; Stevenson, KA; Stitt, AW | 1 |
| Donadieu, E; Lavieille, JP; Magnan, J; Riva, C | 1 |
| Bol, A; Christian, N; De Bast, M; Grégoire, V; Labar, D; Lee, J; Mahy, P | 1 |
| Deveze, A; Donadieu, E; Hamdi, W; Lavieille, JP; Lucciano, M; Magnan, J; Riva, C | 1 |
| Down, JD; Mauch, P; Parmar, K; Sackstein, R; Vergilio, JA | 1 |
| Aly, S; Andries, K; Basaraba, RJ; Cantarero, L; Ehlers, S; Hoff, D; Lenaerts, AJ; Orme, IM | 1 |
| Ito, M; Iwata, R; Kaneta, T; Nakayama, K; Sasaki, T; Takahashi, S; Takai, Y; Tsujitani, M; Yamada, S; Yamaya, M; Yanagihara, K; Yasuda, H | 1 |
| Echevarría, M; López-Barneo, J; Muñoz-Cabello, AM; Sánchez-Silva, R; Toledo-Aral, JJ | 1 |
| Ohno, N; Ohno, S; Saitoh, S; Terada, N | 1 |
| Cheluvappa, R; Cogger, VC; Hilmer, SN; Kwun, SY; LE Couteur, DG | 1 |
| Brader, P; Fong, Y; Hricak, H; Humm, JL; Ling, CC; Reid, V; Riedl, CC; Wen, B; Woo, Y; Zanzonico, P | 1 |
| Abassi, Z; Eckardt, KU; Goldfarb, M; Heyman, SN; Khamaisi, M; Rosen, S; Rosenberger, C; Shilo, V; Shina, A; Weksler-Zangen, S; Zibertrest, F | 1 |
| Chastagner, P; Fouyssac, F; Karcher, G; Pinel, S; Plenat, F; Poussier, S; Scigliano, S | 1 |
| Christian, N; De Bast, M; Geets, X; Gillart, J; Grégoire, V; Labar, D; Lee, J; Levêque, P; Lonneux, M; Mahy, P | 1 |
| Allen, SS; Barry, CE; Carrillo, J; Cho, SN; Eum, SY; Flynn, JL; Gonzales, J; Klein, E; Lee, EG; Lin, PL; Manjunatha, U; McMurray, DN; Park, SK; Raleigh, JA; Ray, SM; Taylor, K; Via, LE | 1 |
| Bijnens, AP; Cleutjens, JP; Corvol, P; Daemen, MJ; Gasc, JM; Groeneweg, M; Kisters, N; Sluimer, JC; Sollewijn Gelpke, MD; van den Akker, LH; van Wanroij, JL; Wouters, BG | 1 |
| Mayr, M; Sidibe, A; Zampetaki, A | 1 |
| Smith, BR | 1 |
| Biaglow, JE; Meltzer, HL; Roizin-Towle, L; Varnes, ME | 1 |
| Brustad, T; Pettersen, EO; Rofstad, EK | 1 |
| Petin, VG | 1 |
| Okajima, S; Okumura, Y | 1 |
| Adams, GE | 1 |
| Maezawa, H; Mori, T; Murayama, C; Ohizumi, Y | 1 |
| Kogelnik, HD | 1 |
| Lee, WW; Narayanan, VL | 1 |
| Brown, JM; Bump, EA; Taylor, YC | 1 |
| Born, JL; Garcia, DJ; Smith, BR | 1 |
| Josephy, PD; Palcic, B; Skarsgard, LD | 1 |
| Goldman, P; Koch, RL; Rich, TA; Rose, C | 1 |
| Salwińska, E; Suwiński, J; Watras, J; Wideł, M | 3 |
| Adams, GE; Horsman, MR; Kandaiya, S; Rajaratnam, S; Smith, E; Stratford, IJ; Williamson, C | 1 |
| Korbelik, M; Palcic, B; Skarsgard, LD | 1 |
| Epp, ER; Ling, CC; Michaels, HB; Peterson, EC | 1 |
| Fielden, EM; Jenkins, TC; Millar, BC | 1 |
| Denekamp, J | 1 |
| Allalunis, MJ; Meeker, BE; Pedersen, JE; Turner, AR; Urtasun, RC | 1 |
| Kuczynski, B; Patel, B; Rumsey, WL | 1 |
| Linder, K; Nunn, A; Strauss, HW | 1 |
| Chan, YW; Cyr, J; Kuczynski, B; Linder, KE; Narra, RK; Nunn, AD; Patel, B; Raju, N; Ramalingam, K; Rumsey, WL | 1 |
| Cline, JM; La Dine, JK; Raleigh, JA; Thrall, DE | 1 |
| Chan, YW; Cyr, JE; Linder, KE; Malley, MF; Nowotnik, DP; Nunn, AD | 1 |
| Cyr, JE; Narra, RK; Raju, N; Rumsey, WL | 1 |
| Johnson, G; Nguyen, KN; Okada, RD; Strauss, HW | 1 |
| Azuma, C; Raleigh, JA; Thrall, DE | 1 |
| Fujiwara, T; Fukuchi, K; Kusuoka, H; Nishimura, T; Watanabe, Y | 1 |
| Hodgkiss, RJ; Webster, L; Wilson, GD | 1 |
| Aboagye, EO; Cannell, MB; Griffiths, JR; Judson, IR; Leach, MO; McSheehy, PM; Ojugo, AS; Robinson, SP | 1 |
| Arteel, GE; Raleigh, JA; Thurman, RG | 1 |
| Arteel, GE; Connor, HD; Frankenberg, MV; Mason, RP; Raleigh, JA; Stachlewitz, RF; Thurman, RG; Yin, M; Zhong, Z | 1 |
| Björnheden, T; Evaldsson, M; Levin, M; Wiklund, O | 1 |
| Björnheden, T; Evaldsson, M; Levin, M; Walenta, S; Wiklund, O | 1 |
| Bunzendahl, H; Raleigh, JA; Schemmer, P; Thurman, RG | 1 |
| Bussink, J; Hodgkiss, RJ; Kaanders, JH; Marres, HA; Peters, JP; Rijken, PF; van der Kogel, AJ | 1 |
| Arteel, GE; Bunzendahl, H; Connor, HD; Mason, RP; Raleigh, JA; Schemmer, P; Thurman, RG | 1 |
| Antoku, S; Ichiya, Y; Maeda, M; Masuda, K; Oka, H; Yamamoto, F | 1 |
| McEwan, AJ; Mercer, JR; Schmidt, RP; Stypinski, D; Tam, YK; Wiebe, LI | 1 |
| Baird, IR; Dolbier, WR; Evans, SM; James, BR; Kachur, AV; Koch, CJ; Li, AR; Roche, A; Shiue, CY; Shiue, GG; Skov, KA | 1 |
| Bakker, JH; Bernsen, HJ; Boerman, RH; Peters, JP; Rijken, PF; van der Kogel, AJ; Wesseling, P | 1 |
| Lee, AE; Wilson, WR | 1 |
| Abu-Zeid, M; Hori, H; Inayama, S; Nagasawa, H; Uto, Y | 1 |
| Bussink, J; de Wilde, PC; Kaanders, JH; Marres, HA; Raleigh, JA; Rijken, PF; van den Hoogen, FJ; van der Kogel, AJ; Wijffels, KI | 1 |
| Bernsen, HJ; Jeuken, JW; Peters, H; Raleigh, JA; Rijken, PF; van der Kogel, AJ; Wesseling, P | 1 |
| d'Hardemare, AD; Fagret, D; Riché, F; Riou, L; Sèpe, S; Vidal, M | 1 |
| Beasley, NJ; Harris, AL; Maxwell, PH; Pastorek, J; Pugh, CW; Ratcliffe, PJ; Sibtain, A; Talks, KL; Turley, H; Turner, KJ; Watson, PH; Wilson, GD; Wykoff, CC | 1 |
| Bae, SK; Chung, HY; Jeong, CH; Kim, KW; Koo, SY; Lee, YM; Raleigh, JA; Son, MJ; Song, HS; Yoo, MA | 1 |
| Hori, H; Inayama, S; Inomata, T; Kasai, S; Kuwasaka, H; Masui, M; Nagasawa, H; Oka, S; Oshodani, T; Uto, Y; Yamashita, M | 1 |
| Georges, B; Grégoire, V; Josse, O; Labar, D; Marchand-Brynaert, J | 1 |
| Bergman, J; Eskola, O; Forsback, S; Grönroos, T; Haaparanta, M; Lehtiö, K; Marjamäki, P; Minn, H; Solin, O | 1 |
| McEwan, AJ; McQuarrie, SA; Mercer, JR; Stypinski, D; Tam, YK; Wiebe, LI | 1 |
| Bergman, J; Eskola, O; Grénman, R; Grönroos, T; Kalliokoski, K; Lehtiö, K; Minn, H; Nuutila, P; Oikonen, V; Solin, O | 1 |
| Aquino-Parsons, C; Banáth, JP; Olive, PL | 1 |
| Balm, A; Begg, AC; Blommestijn, G; Delaere, P; Hofland, I; Janssen, H; Raleigh, JA; Sciot, R; Sprong, D; Van Velthuyzen, L; Varia, M | 1 |
| Braun, RD; Dewhirst, MW; Greer, PK; Gwinn, WM; Hale, LP | 1 |
| Peters, JP; Rijken, PF; Van der Kogel, AJ | 1 |
| Airley, R; Cowen, RL; Honess, D; Jaffar, M; Patterson, AV; Saunders, M; Stratford, IJ; Telfer, BA; van der Kogel, AJ; Williams, KJ; Wolf, CR | 1 |
| Adams, GE; Dische, S; Fowler, JF; Thomlinson, RH | 1 |
| Hall, EJ; Roizin-Towle, L | 1 |
| Karim, AB | 1 |
| Deys, BF; Stap, J | 1 |
| Flockhart, IR; Sheldon, PW; Stratford, IJ; Watts, ME | 1 |
| Phillips, TL | 1 |
| Dische, S | 2 |
| Overgaard, J | 1 |
| de Langen-Omri, F; Guichard, M; Malaise, EP | 1 |
| Palcic, B; Skarsgard, LD; Skov, KA | 1 |
| Wardman, P | 1 |
| Bain, E; Frank, JP; Raju, MR; Trujillo, TT | 1 |
| Pettersen, EO | 1 |
| Milas, L; Stone, HB | 1 |
| Denekamp, J; Flockhart, IR; McNally, NJ; Sheldon, PW | 1 |
| Rauth, AM; Taylor, YC | 1 |
| Gulyas, S; Whitmore, GF; Wong, TW | 1 |
| Hofer, KG; Hofer, MG; Ieracitano, J; McLaughlin, WH | 1 |
| Fowler, JF; Hill, SA | 1 |
| Hill, SA; Sheldon, PW | 1 |
| Astor, M; Biaglow, J; Geard, C; Hall, EJ | 1 |
| Gulyas, S; Mohindra, JK; Varghese, AJ | 1 |
| Fielden, EM | 1 |
| Asquith, JC; Watts, M | 1 |
| Adams, GE; Fowler, JF | 1 |
| Kaufman, K; Rauth, AM | 1 |
| Keizer, HJ; Van Putten, LM | 1 |
| Dische, S; Gray, AJ; Zanelli, GD | 1 |
| Chapman, JD; Golberg, L; Mannan, RH; McEwan, AJ; Mercer, JR; Parliament, MB; Urtasun, RC; Wiebe, LI | 1 |
| Herman, TS; Holden, SA; Teicher, BA | 1 |
| Hodgkiss, RJ; Jones, GW; Long, A; Middleton, RW; Parrick, J; Stratford, MR; Wardman, P; Wilson, GD | 1 |
| Abe, M; Hori, H; Inayama, S; Nagasawa, H; Sasai, K; Shibamoto, Y; Shibata, T; Takahashi, M; Zhou, L | 1 |
| Hirst, DG | 1 |
| Cornago Ramirez, P; Lopez Zumel, C; Santos Peinado, L | 1 |
| Adams, GE; Stratford, IJ | 1 |
| Astor, MB; Biaglow, JE; Clark, EP; Epp, ER; Hall, EJ; Roizen-Towle, L; Varnes, ME | 1 |
| Bussanich, N; Gallie, B; Kumi, C; Palcic, B; Rogers, B; Rootman, J | 1 |
| Inch, WR; Jacobson, EA; Tustanoff, ER | 1 |
| Dischino, DD; Jerabek, PA; Kilbourn, MR; Patrick, TB; Welch, MJ | 1 |
| Heimbrook, DC; Sartorelli, AC; Shyam, K | 1 |
| Varghese, AJ; Whitmore, GF | 1 |
| Mulcahy, RT; Siemann, DW | 1 |
| Edwards, DI | 1 |
| Hall, EJ; Hei, TK | 1 |
| Agrawal, KC; Grodkowski, J; Gupta, RP; Larroquette, CA; Neta, P | 1 |
| Hattori, T; Hori, H; Igarashi, T; Inayama, S; Kitagawa, H; Noguchi, K; Satoh, T; Shibata, T; Ueno, K | 1 |
| Foster, JL; Fowler, JF; Sheldon, PW | 1 |
20 review(s) available for azomycin and Hypoxia
| Article | Year |
|---|---|
Molecular imaging of tumor hypoxia: Evolution of nitroimidazole radiopharmaceuticals and insights for future development.
Topics: Humans; Hypoxia; Molecular Imaging; Nitroimidazoles; Radiopharmaceuticals; Tumor Hypoxia | 2023 |
[Progress in study of nitroimidazole as hypoxia imaging agents in tumor].
Topics: Animals; Humans; Hypoxia; Neoplasms; Nitroimidazoles; Radionuclide Imaging | 2016 |
[Accumulation Mechanism of 2-Nitroimidazole-based Hypoxia Imaging Probes Revealed by Imaging Mass Spectrometry].
Topics: Animals; Glutathione; Glutathione Transferase; Humans; Hypoxia; Mass Spectrometry; Mice; Misonidazole; Molecular Imaging; Molecular Probes; Multidrug Resistance-Associated Proteins; Neoplasms; Nitroimidazoles; Positron-Emission Tomography | 2018 |
[Current Status and Prospects on PET Radiopharmaceuticals for Radiotherapy].
Topics: Animals; Boron Compounds; Boron Neutron Capture Therapy; Coordination Complexes; Fluorine Radioisotopes; Humans; Hypoxia; Misonidazole; Neoplasms; Nitroimidazoles; Organometallic Compounds; Phenylalanine; Positron-Emission Tomography; Radiopharmaceuticals; Thiosemicarbazones | 2015 |
Molecular imaging of hypoxia.
Topics: Humans; Hypoxia; Misonidazole; Neoplasms; Neovascularization, Pathologic; Nitroimidazoles; Positron-Emission Tomography; Radiography; Radiopharmaceuticals | 2011 |
Why is the partial oxygen pressure of human tissues a crucial parameter? Small molecules and hypoxia.
Topics: Animals; Biomarkers; Cell Hypoxia; Erythrocytes; Humans; Hypoxia; Magnetic Resonance Spectroscopy; Mammals; Molecular Imaging; Neoplasms; Nitroimidazoles; Oxygen; Partial Pressure; Polarography; Positron-Emission Tomography; Small Molecule Libraries | 2011 |
Nitroimidazoles as anti-tumor agents.
Topics: Animals; Antineoplastic Agents; Biotransformation; Humans; Hypoxia; Neoplasms; Nitroimidazoles; Oxidation-Reduction; Oxygen; Prodrugs; Radiation-Sensitizing Agents; Tumor Cells, Cultured | 2011 |
PET of hypoxia: current and future perspectives.
Topics: Etanidazole; Humans; Hydrocarbons, Fluorinated; Hypoxia; Nitroimidazoles; Positron-Emission Tomography; Radioactive Tracers; Triazoles | 2012 |
A phase I study of SR-4554 via intravenous administration for noninvasive investigation of tumor hypoxia by magnetic resonance spectroscopy in patients with malignancy.
Topics: Adult; Aged; Biomarkers, Tumor; Chromatography, High Pressure Liquid; Female; Fluorine Radioisotopes; Half-Life; Humans; Hypoxia; Infusions, Intravenous; Magnetic Resonance Spectroscopy; Male; Maximum Tolerated Dose; Metabolic Clearance Rate; Middle Aged; Neoplasms; Nitroimidazoles | 2003 |
Current issues in the utility of 19F nuclear magnetic resonance methodologies for the assessment of tumour hypoxia.
Topics: Fluorine; Fluorocarbons; Humans; Hypoxia; Magnetic Resonance Spectroscopy; Neoplasms; Nitroimidazoles; Oximetry | 2004 |
The role of functional and molecular imaging in cancer drug discovery and development.
Topics: Antineoplastic Agents; Benzoquinones; Diagnostic Imaging; HSP90 Heat-Shock Proteins; Humans; Hypoxia; Lactams, Macrocyclic; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Neoplasms; Nitroimidazoles; Positron-Emission Tomography; Rifabutin; Technology, Pharmaceutical; Ultrasonography | 2003 |
Exogenous and endogenous markers of tumour oxygenation status: definitive markers of tumour hypoxia?
Topics: Antigens, Neoplasm; Biomarkers; Carbonic Anhydrase IX; Carbonic Anhydrases; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Neoplasms; Nitroimidazoles; Oxygen | 2005 |
Development of radiosensitizers: a medicinal chemistry perspective.
Topics: Animals; Electrons; Heterocyclic Compounds; Humans; Hypoxia; Nitrobenzenes; Nitroimidazoles; Radiation-Sensitizing Agents; Solubility; Structure-Activity Relationship | 1982 |
Nitroimidazoles and imaging hypoxia.
Topics: Animals; Humans; Hypoxia; Nitroimidazoles; Radioisotopes; Radionuclide Imaging | 1995 |
Radiation sensitizers.
Topics: Animals; Antineoplastic Agents; Bromodeoxycytidine; Bromodeoxyuridine; Carcinoma; Deoxyuridine; Dogs; Dose-Response Relationship, Radiation; Floxuridine; Humans; Hypoxia; Idoxuridine; Lung Neoplasms; Methotrexate; Metronidazole; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Nitroimidazoles; Radiation-Sensitizing Agents; Research; Sarcoma, Experimental; Skin | 1976 |
Chemical modification of radiation effects.
Topics: Animals; Antineoplastic Agents; Bromodeoxyuridine; Cell Survival; Cysteamine; DNA; Drug Evaluation; Drug Interactions; Humans; Hypoxia; Metronidazole; Neoplasms; Neoplasms, Experimental; Nitroimidazoles; Radiation Effects; Radiation-Protective Agents; Radiation-Sensitizing Agents | 1977 |
Radiosensitizers in the treatment of squamous cell carcinoma of the head and neck.
Topics: Animals; Carcinoma, Squamous Cell; Head and Neck Neoplasms; Humans; Hyperbaric Oxygenation; Hypoxia; Metronidazole; Mice; Nitroimidazoles; Radiation Tolerance; Radiation-Sensitizing Agents | 1977 |
Hypoxia-mediated nitro-heterocyclic drugs in the radio- and chemotherapy of cancer. An overview.
Topics: Alkylating Agents; Animals; Cell Survival; Drug Synergism; Etanidazole; Hypoxia; Misonidazole; Neoplasms, Experimental; Nitrofurans; Nitrofurazone; Nitroimidazoles; Oxidation-Reduction; Radiation-Sensitizing Agents; Structure-Activity Relationship | 1986 |
Biochemistry of reduction of nitro heterocycles.
Topics: Animals; Buthionine Sulfoximine; Catalase; Cell Division; Cell Survival; Etanidazole; Free Radicals; Glucose; Glutathione; Glycolysis; Hexosephosphates; Humans; Hypoxia; Methionine Sulfoximine; Microbodies; Microsomes; Misonidazole; Mitochondria; Nitroimidazoles; Oxidation-Reduction; Pentoses; Peroxidases; Sulfhydryl Compounds | 1986 |
The biological properties of reduced nitroheterocyclics and possible underlying biochemical mechanisms.
Topics: Animals; Dose-Response Relationship, Drug; Drug Synergism; Free Radicals; Glutathione; Humans; Hydroxylamines; Hypoxia; Nitrofurans; Nitroimidazoles; Nucleic Acids; Oxidation-Reduction; Proteins; Radiation-Sensitizing Agents; Sulfhydryl Compounds | 1986 |
12 trial(s) available for azomycin and Hypoxia
| Article | Year |
|---|---|
Correlation and colocalization of HIF-1α and pimonidazole staining for hypoxia in laryngeal squamous cell carcinomas: A digital, single-cell-based analysis.
Topics: Biomarkers; Biomarkers, Tumor; Cell Hypoxia; Head and Neck Neoplasms; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Laryngeal Neoplasms; Nitroimidazoles; Prognosis; Squamous Cell Carcinoma of Head and Neck; Staining and Labeling | 2022 |
A Phase II Randomized Trial of Chemoradiation with or without Metformin in Locally Advanced Cervical Cancer.
Topics: COVID-19; Female; Humans; Hypoxia; Metformin; Nitroimidazoles; Pandemics; Positron Emission Tomography Computed Tomography; Positron-Emission Tomography; Radiopharmaceuticals; Uterine Cervical Neoplasms | 2022 |
Hypoxia-activated evofosfamide for treatment of recurrent bevacizumab-refractory glioblastoma: a phase I surgical study.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Brain Neoplasms; Combined Modality Therapy; Drug Resistance, Neoplasm; Female; Follow-Up Studies; Glioblastoma; Humans; Hypoxia; Male; Middle Aged; Neoplasm Recurrence, Local; Nitroimidazoles; Phosphoramide Mustards; Prognosis; Salvage Therapy | 2018 |
Phase I/II study of the hypoxia-activated prodrug PR104 in refractory/relapsed acute myeloid leukemia and acute lymphoblastic leukemia.
Topics: Adult; Aged; Anemia; Antigens, Neoplasm; Antineoplastic Agents, Alkylating; Biomarkers; Bone Marrow; Carbonic Anhydrase IX; Carbonic Anhydrases; Enterocolitis; Female; Gene Expression; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Leukemia, Myeloid, Acute; Male; Middle Aged; Neutropenia; Nitrogen Mustard Compounds; Nitroimidazoles; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prodrugs; Recurrence; Remission Induction; Thrombocytopenia | 2015 |
Phase I study of evofosfamide, an investigational hypoxia-activated prodrug, in patients with advanced leukemia.
Topics: Adult; Aged; Bone Marrow; Esophagitis; Female; Humans; Hyperbilirubinemia; Hypoxia; Leukemia; Leukemia, Myeloid, Acute; Male; Maximum Tolerated Dose; Middle Aged; Nitroimidazoles; Phosphoramide Mustards; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prodrugs; Salvage Therapy; Stomatitis; Young Adult | 2016 |
A Comparative Study of Noninvasive Hypoxia Imaging with 18F-Fluoroerythronitroimidazole and 18F-Fluoromisonidazole PET/CT in Patients with Lung Cancer.
Topics: Adult; Aged; Demography; Female; Humans; Hypoxia; Lung Neoplasms; Male; Middle Aged; Misonidazole; Nitroimidazoles; Positron Emission Tomography Computed Tomography; Tissue Distribution | 2016 |
Initial results of hypoxia imaging using 1-alpha-D: -(5-deoxy-5-[18F]-fluoroarabinofuranosyl)-2-nitroimidazole ( 18F-FAZA).
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Carcinoma, Squamous Cell; Female; Fluorine Radioisotopes; Glioma; Head and Neck Neoplasms; Humans; Hypoxia; Lung Neoplasms; Lymphoma; Male; Middle Aged; Neoplasms; Nitroimidazoles; Positron-Emission Tomography; Radiopharmaceuticals; Young Adult | 2009 |
Biodistribution and radiation dosimetry of the hypoxia marker 18F-HX4 in monkeys and humans determined by using whole-body PET/CT.
Topics: Animals; Biomarkers; Female; Haplorhini; Humans; Hypoxia; Male; Middle Aged; Nitroimidazoles; Positron-Emission Tomography; Radiometry; Radiopharmaceuticals; Species Specificity; Tomography, X-Ray Computed; Triazoles; Whole Body Imaging | 2010 |
A phase I study of SR-4554 via intravenous administration for noninvasive investigation of tumor hypoxia by magnetic resonance spectroscopy in patients with malignancy.
Topics: Adult; Aged; Biomarkers, Tumor; Chromatography, High Pressure Liquid; Female; Fluorine Radioisotopes; Half-Life; Humans; Hypoxia; Infusions, Intravenous; Magnetic Resonance Spectroscopy; Male; Maximum Tolerated Dose; Metabolic Clearance Rate; Middle Aged; Neoplasms; Nitroimidazoles | 2003 |
Determination of tumour hypoxia with [18F]EF3 in patients with head and neck tumours: a phase I study to assess the tracer pharmacokinetics, biodistribution and metabolism.
Topics: Adult; Aged; Carcinoma, Squamous Cell; Female; Head and Neck Neoplasms; Humans; Hypoxia; Laryngeal Neoplasms; Male; Middle Aged; Nitroimidazoles; Pharyngeal Neoplasms; Positron-Emission Tomography; Radiopharmaceuticals; Tissue Distribution | 2008 |
Hypoxia and perfusion measurements in human tumors--initial experience with pimonidazole and IUdR.
Topics: Antibodies; Biopsy; Diffusion; Esophageal Neoplasms; Female; Head and Neck Neoplasms; Humans; Hypoxia; Idoxuridine; Kinetics; Male; Nitroimidazoles; Nucleic Acid Synthesis Inhibitors; Radiation-Sensitizing Agents; Rectal Neoplasms; Regional Blood Flow; Specimen Handling; Uterine Cervical Neoplasms | 2001 |
Hypoxic cell sensitisers in radiotherapy.
Topics: Animals; Clinical Trials as Topic; Drug Evaluation; Drug Evaluation, Preclinical; Humans; Hypoxia; In Vitro Techniques; Mice; Neoplasms; Neoplasms, Experimental; Nitroimidazoles; Oxygen Consumption; Radiation-Sensitizing Agents; Radiotherapy Dosage | 1976 |
258 other study(ies) available for azomycin and Hypoxia
| Article | Year |
|---|---|
Targeting tumor hypoxia: a third generation 2-nitroimidazole-indocyanine dye-conjugate with improved fluorescent yield.
Topics: Animals; Cell Hypoxia; Cell Line, Tumor; Fluorescent Dyes; Hypoxia; Indocyanine Green; Mice, Inbred BALB C; Neoplasms; Nitroimidazoles; Optical Imaging | 2015 |
[99mTc]Technetium labelled PnAo-azomycin glucuronides: a novel class of imaging markers of tissue hypoxia.
Topics: Animals; Glucuronides; HeLa Cells; Humans; Hypoxia; Mice; Mice, Inbred BALB C; Neoplasms, Experimental; Nitroimidazoles; Organotechnetium Compounds; Oximes; Radionuclide Imaging; Radiopharmaceuticals; Tumor Cells, Cultured | 2002 |
Topics: Cell Hypoxia; CTLA-4 Antigen; Humans; Hypoxia; Misonidazole; Neoplasms; Nitroimidazoles; Phosphoramide Mustards; Positron-Emission Tomography; Programmed Cell Death 1 Receptor; Tumor Microenvironment | 2022 |
Immunofluorescence-Based Method to Assess Cancer Biomarker in the Hypoxic Region of the Tumor.
Topics: Biomarkers, Tumor; Cell Hypoxia; Fluorescent Antibody Technique; Humans; Hypoxia; Neoplasms; Nitroimidazoles; Tumor Microenvironment | 2022 |
Cellular mechanism of action of 2-nitroimidazoles as hypoxia-selective therapeutic agents.
Topics: Animals; Cell Hypoxia; Cell Line, Tumor; Head and Neck Neoplasms; Hypoxia; Mice; Nitroimidazoles | 2022 |
PET/CT features of a novel gallium-68 labelled hypoxia seeking agent in patients diagnosed with tuberculosis: a proof-of-concept study.
Topics: Gallium Radioisotopes; Humans; Hypoxia; Lung Diseases; Nitroimidazoles; Positron Emission Tomography Computed Tomography; Positron-Emission Tomography; Radiopharmaceuticals; Tuberculosis | 2022 |
A Hypoxia-Sensitive Drug Delivery System Constructed by Nitroimidazole and its Application in the Treatment of Hepatocellular Carcinoma.
Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Line, Tumor; Drug Carriers; Drug Delivery Systems; Folic Acid; Humans; Hypoxia; Liver Neoplasms; Micelles; Nitroimidazoles; Polyethylene Glycols; Tumor Microenvironment | 2022 |
Hypoxia-responsive nanocarriers for chemotherapy sensitization via dual-mode inhibition of hypoxia-inducible factor-1 alpha.
Topics: Antineoplastic Agents; Aspartic Acid; Caspase 3; Cell Hypoxia; Cell Line, Tumor; Cytochromes c; Dicumarol; Female; Glutathione; Humans; Hypoxia; Micelles; NAD; NADP; Nitroimidazoles; Oxygen; Phosphates; Polyethylene Glycols; Polymers; Quinones; Sorafenib; Thioredoxins | 2022 |
Assessment of hypoxia by pimonidazole staining following radiotherapy.
Topics: Biomarkers; Cell Hypoxia; Humans; Hypoxia; Neoplasms; Nitroimidazoles; Oxygen; Staining and Labeling; Tumor Microenvironment | 2022 |
Coenzyme-depleting nanocarriers for enhanced redox cancer therapy under hypoxia.
Topics: Animals; Antioxidants; Cell Line, Tumor; Coenzymes; Glutathione; Humans; Hypoxia; Mice; NADP; Neoplasms; Nitroimidazoles; Oxidation-Reduction; Sorafenib | 2023 |
Design, Synthesis and Anticancer Evaluation of Nitroimidazole Radiosensitisers.
Topics: Cell Hypoxia; Humans; Hypoxia; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents | 2023 |
Discovery of novel hypoxia-activated, nitroimidazole constructed multi-target kinase inhibitors on the basis of AZD9291 for the treatment of human lung cancer.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; ErbB Receptors; Humans; Hypoxia; Lung Neoplasms; Nitroimidazoles; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Structure-Activity Relationship | 2023 |
Persistence and expansion of hypoxia detected by pimonidazole adduct immunostaining during progression of diabetic nephropathy in diabetic mice.
Topics: Animals; Child, Preschool; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Mice; Nitroimidazoles | 2023 |
Chronic exposure to hypoxia attenuates renal injury and innate immunity activation in the remnant kidney model.
Topics: Animals; Gene Expression Regulation; Hypoxia; Immunity, Innate; Kidney; Male; Nephrectomy; Nitroimidazoles; Organ Size; Oxygen; Radiation-Sensitizing Agents; Rats; Renal Insufficiency, Chronic | 2019 |
Correlation of hypoxia as measured by fluorine-18 fluoroerythronitroimidazole (
Topics: Fluorine Radioisotopes; Fluorodeoxyglucose F18; Glioma; Humans; Hypoxia; Nitroimidazoles; Positron Emission Tomography Computed Tomography; Positron-Emission Tomography; Radiopharmaceuticals; Vascular Endothelial Growth Factor A | 2020 |
Influence of FAZA PET hypoxia and HPV-status for the outcome of head and neck squamous cell carcinoma (HNSCC) treated with radiotherapy: Long-term results from the DAHANCA 24 trial (NCT01017224).
Topics: Carcinoma, Squamous Cell; Cell Hypoxia; Head and Neck Neoplasms; Humans; Hypoxia; Neoplasm Recurrence, Local; Nitroimidazoles; Papillomavirus Infections; Positron Emission Tomography Computed Tomography; Positron-Emission Tomography; Prospective Studies; Radiopharmaceuticals; Squamous Cell Carcinoma of Head and Neck | 2020 |
Deep-learning and MR images to target hypoxic habitats with evofosfamide in preclinical models of sarcoma.
Topics: Animals; Artificial Intelligence; Cell Line, Tumor; Deep Learning; Disease Models, Animal; Doxorubicin; Ecosystem; Female; Humans; Hypoxia; Magnetic Resonance Imaging; Mice; Mice, Inbred C3H; Mice, SCID; Nitroimidazoles; Phosphoramide Mustards; Prodrugs; Sarcoma; Soft Tissue Neoplasms; Xenograft Model Antitumor Assays | 2021 |
Exploiting the Role of Hypoxia-Inducible Factor 1 and Pseudohypoxia in the Myelodysplastic Syndrome Pathophysiology.
Topics: Aged; Aged, 80 and over; Antigens, CD34; Autophagy; Bone Marrow; Cell Differentiation; Cell Lineage; Cell Proliferation; Female; Humans; Hypoxia; Hypoxia-Inducible Factor 1; Male; Middle Aged; Mitophagy; Myelodysplastic Syndromes; Myeloid Cells; Nitroimidazoles; Transcription Factors; Up-Regulation | 2021 |
Maternal nutrient restriction in guinea pigs leads to fetal growth restriction with evidence for chronic hypoxia.
Topics: Animals; Cohort Studies; Erythropoietin; Female; Fetal Development; Fetal Growth Retardation; Guinea Pigs; Hypoxia; Immunohistochemistry; Male; Maternal Nutritional Physiological Phenomena; Maternal-Fetal Exchange; Nitroimidazoles; Placenta; Pregnancy; Signal Transduction; Vascular Endothelial Growth Factor A | 2017 |
Altered glucose metabolism and hypoxic response in alloxan-induced diabetic atherosclerosis in rabbits.
Topics: Alloxan; Animals; Apoptosis; Atherosclerosis; Autoradiography; Body Weight; Cluster Analysis; Diabetes Mellitus, Experimental; Diet, High-Fat; Electrophoresis, Capillary; Femoral Artery; Fluorodeoxyglucose F18; Glucose; Glycolysis; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Macrophages; Mass Spectrometry; Metabolomics; Microscopy, Fluorescence; Nitroimidazoles; Principal Component Analysis; Rabbits | 2017 |
Hypoxia-activated prodrug TH-302 decreased survival rate of canine lymphoma cells under hypoxic condition.
Topics: Animals; Antineoplastic Agents; ATP-Binding Cassette Transporters; Cell Hypoxia; Cell Line, Tumor; Cell Survival; Dogs; Gene Expression Regulation, Neoplastic; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Lymphoma; Nitroimidazoles; Phosphoramide Mustards; Platelet-Derived Growth Factor; Prodrugs; Up-Regulation; Vascular Endothelial Growth Factor A | 2017 |
Dynamic contrast-enhanced MRI of the microenvironment of pancreatic adenocarcinoma xenografts.
Topics: Animals; Carcinoma, Pancreatic Ductal; Contrast Media; Extracellular Fluid; Female; Heterocyclic Compounds; Heterografts; Humans; Hypoxia; Magnetic Resonance Imaging; Mice; Mice, Inbred BALB C; Mice, Nude; Microvessels; Neoplasm Transplantation; Nitroimidazoles; Organometallic Compounds; Pancreatic Neoplasms; Platelet Endothelial Cell Adhesion Molecule-1; Pressure; Tumor Microenvironment | 2017 |
Radiotherapy Synergizes with the Hypoxia-Activated Prodrug Evofosfamide: In Vitro and In Vivo Studies.
Topics: Animals; Cell Hypoxia; Cell Line, Tumor; Cell Survival; Disease Models, Animal; DNA Damage; Humans; Hypoxia; Mice; Nitroimidazoles; Oxidation-Reduction; Phosphoramide Mustards; Prodrugs; Radiotherapy; Tumor Burden; Xenograft Model Antitumor Assays | 2018 |
In Vivo Imaging of Retinal Hypoxia Using HYPOX-4-Dependent Fluorescence in a Mouse Model of Laser-Induced Retinal Vein Occlusion (RVO).
Topics: Animals; Disease Models, Animal; Fluorescein Angiography; Fluoresceins; Fluorescent Dyes; Hypoxia; Image Processing, Computer-Assisted; Macular Edema; Male; Mice; Mice, Inbred C57BL; Nitroimidazoles; Radiation-Sensitizing Agents; Retinal Neovascularization; Retinal Vein; Retinal Vein Occlusion; Tomography, Optical Coherence | 2017 |
Sounding Out Dysfunctional Oxygen Metabolism: A Small-Molecule Probe for Photoacoustic Imaging of Hypoxia.
Topics: Animals; Cyclic N-Oxides; Humans; Hypoxia; Molecular Imaging; Nitroimidazoles; Oxygen; Photoacoustic Techniques | 2018 |
Selective cancer treatment via photodynamic sensitization of hypoxia-responsive drug delivery.
Topics: Animals; Cell Line, Tumor; Doxorubicin; Drug Delivery Systems; Female; Hyaluronic Acid; Hypoxia; Mice, Inbred C57BL; Micelles; Nanoparticles; Neoplasms, Experimental; Nitroimidazoles; Photoacoustic Techniques; Photochemotherapy; Polyethyleneimine; Tissue Distribution | 2018 |
Evaluation of Vascularity, Blood Perfusion, and Oxygen Tension in Tumor Xenografts with Fluorescent Microscopy.
Topics: Animals; Disease Models, Animal; Fluorescent Antibody Technique; Heterografts; Humans; Hypoxia; Mice; Microscopy, Fluorescence; Neoplasm Staging; Neoplasms; Neovascularization, Pathologic; Nitroimidazoles; Oxygen | 2018 |
Administration of Hypoxia-Activated Prodrug Evofosfamide after Conventional Adjuvant Therapy Enhances Therapeutic Outcome and Targets Cancer-Initiating Cells in Preclinical Models of Colorectal Cancer.
Topics: Animals; Biomarkers; Caspases; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Chemoradiotherapy; Colorectal Neoplasms; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Synergism; Female; Humans; Hypoxia; Male; Mice; Neoplastic Stem Cells; Nitroimidazoles; Phenotype; Phosphoramide Mustards; Positron-Emission Tomography; Prodrugs; Standard of Care; Wnt Signaling Pathway; Xenograft Model Antitumor Assays | 2018 |
Efficacy of the hypoxia-activated prodrug evofosfamide (TH-302) in nasopharyngeal carcinoma in vitro and in vivo.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Hypoxia; Cell Line, Tumor; Cell Survival; Cisplatin; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Mice, Inbred BALB C; Mice, Nude; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms; Nitroimidazoles; Phosphoramide Mustards; Prodrugs; Treatment Outcome; Xenograft Model Antitumor Assays | 2018 |
A Novel PET Probe "[
Topics: Animals; Fluorine Radioisotopes; Glutathione; Head and Neck Neoplasms; Heterografts; Humans; Hypoxia; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Nitroimidazoles; Oxidation-Reduction; Oxidative Stress; Positron-Emission Tomography; Tissue Distribution; Tumor Cells, Cultured; Tumor Hypoxia | 2019 |
Mechanistic insight into the singlet oxygen-triggered expansion of hypoxia-responsive polymeric micelles.
Topics: Animals; Cell Line, Tumor; Cell Survival; Chlorophyllides; Drug Carriers; Drug Compounding; Epithelial Cells; Hypoxia; Light; Mice; Micelles; Nanomedicine; Nitroimidazoles; Peptides; Photosensitizing Agents; Polyethylene Glycols; Polymerization; Porphyrins; Singlet Oxygen | 2018 |
Intravital Imaging to Monitor Therapeutic Response in Moving Hypoxic Regions Resistant to PI3K Pathway Targeting in Pancreatic Cancer.
Topics: Animals; Benzamides; Cell Line, Tumor; Drug Resistance, Neoplasm; Drug Therapy, Combination; Female; Fluorescence Resonance Energy Transfer; Humans; Hypoxia; Intravital Microscopy; Mice; Mice, Inbred BALB C; Morpholines; Nanoparticles; Nitroimidazoles; Pancreatic Neoplasms; Phosphatidylinositol 3-Kinases; Phosphoramide Mustards; Proto-Oncogene Proteins c-akt; Pyrimidines; Signal Transduction; Transplantation, Heterologous; Tumor Microenvironment | 2018 |
An Intratumor Pharmacokinetic/Pharmacodynamic Model for the Hypoxia-Activated Prodrug Evofosfamide (TH-302): Monotherapy Activity is Not Dependent on a Bystander Effect.
Topics: Algorithms; Animals; Antineoplastic Agents; Biological Transport; Bystander Effect; Cell Culture Techniques; Cell Line, Tumor; Chromatography, Liquid; Humans; Hydroxylamine; Hypoxia; Models, Biological; Nitroimidazoles; Phosphoramide Mustards; Prodrugs; Tandem Mass Spectrometry | 2019 |
Hypoxia-Activated Prodrugs of PERK Inhibitors.
Topics: Dose-Response Relationship, Drug; Drug Design; eIF-2 Kinase; HCT116 Cells; Humans; Hypoxia; Molecular Structure; Nitroimidazoles; Prodrugs; Protein Kinase Inhibitors; Structure-Activity Relationship; Tumor Cells, Cultured | 2019 |
In Vivo Ester Hydrolysis as a New Approach in Development of Positron Emission Tomography Tracers for Imaging Hypoxia.
Topics: Animals; Cell Hypoxia; Cell Line, Tumor; Disease Models, Animal; Esters; Female; Fluorine Radioisotopes; Hydrolysis; Hypoxia; Male; Mice; Mice, Inbred BALB C; Neoplasms; Nitroimidazoles; Positron-Emission Tomography; Radioactive Tracers; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Tissue Distribution | 2019 |
The Combination Rifampin-Nitazoxanide, but Not Rifampin-Isoniazid-Pyrazinamide-Ethambutol, Kills Dormant Mycobacterium tuberculosis in Hypoxia at Neutral pH.
Topics: Antitubercular Agents; Drug Combinations; Drug Therapy, Combination; Ethambutol; Humans; Hydrogen-Ion Concentration; Hypoxia; Isoniazid; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Nitroimidazoles; Oxazolidinones; Pyrazinamide; Rifampin; Tuberculosis | 2019 |
Adipose tissue hypoxia induces inflammatory M1 polarity of macrophages in an HIF-1α-dependent and HIF-1α-independent manner in obese mice.
Topics: Adipose Tissue; Alleles; Animals; Bone Marrow Cells; Cell Polarity; Flow Cytometry; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Inflammation; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Obese; Nitroimidazoles; Phenotype | 2013 |
The teratogenic effect of dofetilide during rat limb development and association with drug-induced bradycardia and hypoxia in the embryo.
Topics: Abnormalities, Drug-Induced; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bradycardia; Heart; Hypoxia; Limb Deformities, Congenital; Nitroimidazoles; Phenethylamines; Rats; Rats, Sprague-Dawley; Sulfonamides; Teratogens | 2013 |
Synthesis of new 18F-radiolabeled silicon-based nitroimidazole compounds.
Topics: Animals; Fluorine Radioisotopes; Humans; Hypoxia; Nitroimidazoles; Positron-Emission Tomography; Rats; Rats, Wistar; Silicon; Tissue Distribution | 2013 |
Targeting tumor hypoxia with 2-nitroimidazole-indocyanine green dye conjugates.
Topics: Animals; Cell Line, Tumor; Coloring Agents; Equipment Design; Ethanolamine; Female; Hypoxia; Immunohistochemistry; Indocyanine Green; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Neoplasms; Nitroimidazoles; Spectrometry, Fluorescence; Time Factors | 2013 |
PET imaging of tumor hypoxia using 18F-labeled pimonidazole.
Topics: Animals; Carcinoma, Squamous Cell; Female; Fluorodeoxyglucose F18; Head and Neck Neoplasms; Humans; Hypoxia; Mammary Neoplasms, Animal; Mice; Mice, Inbred C3H; Mice, Nude; Nitroimidazoles; Positron-Emission Tomography; Radiation-Sensitizing Agents; Radiopharmaceuticals; Tumor Cells, Cultured | 2013 |
Hypoxia-targeting carbonic anhydrase IX inhibitors by a new series of nitroimidazole-sulfonamides/sulfamides/sulfamates.
Topics: Amides; Antigens, Neoplasm; Carbonic Anhydrase IX; Carbonic Anhydrases; Dose-Response Relationship, Drug; Enzyme Inhibitors; HeLa Cells; HT29 Cells; Humans; Hypoxia; Models, Molecular; Molecular Structure; Nitroimidazoles; Structure-Activity Relationship; Sulfonamides; Sulfonic Acids | 2013 |
Microwave-assisted radiosynthesis of the hypoxia marker 1-α-D-(5- deoxy-5-[18F]fluoroarabinofuranosyl)-2-nitroimidazole ([18F]FAZA).
Topics: Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Fluorine Radioisotopes; Hot Temperature; Humans; Hypoxia; Kinetics; Microwaves; Nitroimidazoles; Radiochemistry; Radiopharmaceuticals | 2014 |
Molecular probes for imaging of hypoxia in the retina.
Topics: Animals; Cell Line; Cell Survival; Fluorescein-5-isothiocyanate; Humans; Hypoxia; Mice; Molecular Imaging; Molecular Probes; Nitroimidazoles; Retina; Retinal Neurons | 2014 |
High-uptake areas on positron emission tomography with the hypoxic radiotracer (18)F-FRP170 in glioblastomas include regions retaining proliferative activity under hypoxia.
Topics: Adult; Aged; Brain; Brain Neoplasms; Female; Glioblastoma; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Ki-67 Antigen; Male; Middle Aged; Nitroimidazoles; Positron-Emission Tomography; Radiopharmaceuticals | 2015 |
The reverse Warburg effect and 18F-FDG uptake in non-small cell lung cancer A549 in mice: a pilot study.
Topics: Animals; Blood Glucose; Body Weight; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Diet; Female; Fluorodeoxyglucose F18; Glucose; Humans; Hypoxia; Lung Neoplasms; Mice; Mice, Nude; Neoplasm Transplantation; Nitroimidazoles; Pilot Projects; Positron-Emission Tomography; Radiopharmaceuticals; Tumor Microenvironment | 2015 |
Automated radiosynthesis of GMP quality [18F]HX4 for PET imaging of hypoxia.
Topics: Automation; Hypoxia; Nitroimidazoles; Positron-Emission Tomography; Quality Control; Radiochemistry; Triazoles | 2015 |
Hypoxic viable tissue in human chronic cerebral ischemia because of unilateral major cerebral artery steno-occlusive disease.
Topics: Adult; Aged; Aged, 80 and over; Arterial Occlusive Diseases; Brain Chemistry; Brain Ischemia; Cerebral Arterial Diseases; Cerebrovascular Circulation; Chronic Disease; Female; Humans; Hypoxia; Infarction, Middle Cerebral Artery; Male; Middle Aged; Nitroimidazoles; Oxygen Consumption; Oxygen Radioisotopes; Positron-Emission Tomography; Predictive Value of Tests; Radiopharmaceuticals | 2015 |
64Cu-ATSM Hypoxia Positron Emission Tomography for Detection of Conduit Ischemia in an Experimental Rat Esophagectomy Model.
Topics: Anastomotic Leak; Animals; Autoradiography; Coordination Complexes; Copper Radioisotopes; Esophagectomy; Esophagogastric Junction; Gastric Fundus; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Ischemia; Male; Nitroimidazoles; Organometallic Compounds; Positron-Emission Tomography; Rats; Rats, Sprague-Dawley; Thiosemicarbazones | 2015 |
Comparison of [18F]-FMISO, [18F]-FAZA and [18F]-HX4 for PET imaging of hypoxia--a simulation study.
Topics: Humans; Hypoxia; Imidazoles; Misonidazole; Models, Theoretical; Nitroimidazoles; Positron-Emission Tomography; Radiopharmaceuticals; Triazoles | 2015 |
Assessment of hypoxic subvolumes in laryngeal cancer with (18)F-fluoroazomycinarabinoside ((18)F-FAZA)-PET/CT scanning and immunohistochemistry.
Topics: Aged; Aged, 80 and over; Biomarkers; Carcinoma, Squamous Cell; Female; Head and Neck Neoplasms; Humans; Hypoxia; Laryngeal Neoplasms; Laryngectomy; Male; Middle Aged; Multimodal Imaging; Neoplasm Recurrence, Local; Nitroimidazoles; Pilot Projects; Positron-Emission Tomography; Prospective Studies; Radiopharmaceuticals; Squamous Cell Carcinoma of Head and Neck; Tomography, X-Ray Computed | 2015 |
Methoxy poly (ethylene glycol)-block-poly (glutamic acid)-graft-6-(2-nitroimidazole) hexyl amine nanoparticles for potential hypoxia-responsive delivery of doxorubicin.
Topics: Adenocarcinoma; Antibiotics, Antineoplastic; Breast Neoplasms; Cell Survival; Doxorubicin; Drug Carriers; Humans; Hydrophobic and Hydrophilic Interactions; Hypoxia; MCF-7 Cells; Micelles; Nanoparticles; Nitroimidazoles; Polyglutamic Acid; Proton Magnetic Resonance Spectroscopy; Spectroscopy, Fourier Transform Infrared; Tumor Microenvironment | 2016 |
Hypoxia-Activated Prodrug TH-302 Targets Hypoxic Bone Marrow Niches in Preclinical Leukemia Models.
Topics: Animals; Antineoplastic Agents; Bone Marrow; Cell Line, Tumor; Disease Models, Animal; Gene Expression Profiling; Gene Expression Regulation, Leukemic; Humans; Hypoxia; Leukemia; Magnetic Resonance Imaging; Mice; Nitroimidazoles; Phosphoramide Mustards; Prodrugs; Treatment Outcome; Tumor Microenvironment; Xenograft Model Antitumor Assays | 2016 |
Development of (68)Ga-labeled multivalent nitroimidazole derivatives for hypoxia imaging.
Topics: Animals; Cell Line, Tumor; Colon; Colonic Neoplasms; Gallium Radioisotopes; Humans; Hypoxia; Mice; Mice, Inbred BALB C; Nitroimidazoles; Positron-Emission Tomography; Tissue Distribution | 2015 |
Multiparametric Analysis of the Relationship Between Tumor Hypoxia and Perfusion with ¹⁸F-Fluoroazomycin Arabinoside and ¹⁵O-H₂O PET.
Topics: Aged; Carcinoma, Non-Small-Cell Lung; Cluster Analysis; Female; Humans; Hypoxia; Lung Neoplasms; Male; Middle Aged; Neoplasms; Nitroimidazoles; Oxygen Radioisotopes; Positron-Emission Tomography; Radiopharmaceuticals; Regional Blood Flow; Water | 2016 |
In vitro and in vivo evaluation of technetium-99m-labeled propylene amine oxime complexes containing nitroimidazole and nitrotriazole groups as hypoxia markers.
Topics: Animals; Cell Line, Tumor; Hypoxia; Male; Mice; Nitroimidazoles; Organotechnetium Compounds; Oximes; Radionuclide Imaging; Radiopharmaceuticals; Tissue Distribution; Triazoles | 2016 |
Measurement of Tumor Hypoxia in Patients with Advanced Pancreatic Cancer Based on 18F-Fluoroazomyin Arabinoside Uptake.
Topics: Aged; Aged, 80 and over; Algorithms; Female; Humans; Hypoxia; Male; Middle Aged; Models, Biological; Neoplasm Metastasis; Nitroimidazoles; Pancreatic Neoplasms; Positron-Emission Tomography; Radiopharmaceuticals; Regional Blood Flow | 2016 |
Histological Image Processing Features Induce a Quantitative Characterization of Chronic Tumor Hypoxia.
Topics: Algorithms; Animals; Cell Line, Tumor; Colonic Neoplasms; Humans; Hypoxia; Image Processing, Computer-Assisted; Mice; Mice, Nude; Nitroimidazoles | 2016 |
MR Imaging Biomarkers to Monitor Early Response to Hypoxia-Activated Prodrug TH-302 in Pancreatic Cancer Xenografts.
Topics: Animals; Biomarkers, Tumor; Cell Line, Tumor; Female; Humans; Hypoxia; Magnetic Resonance Imaging; Mice; Mice, SCID; Nitroimidazoles; Pancreatic Neoplasms; Phosphoramide Mustards; Prodrugs; Time Factors; Xenograft Model Antitumor Assays | 2016 |
Cerebral and extracerebral vulnerability to hypoxic insults after diffuse traumatic brain injury in rats.
Topics: Animals; Arterial Pressure; Brain; Brain Injuries, Traumatic; Disease Models, Animal; Hypotension; Hypoxia; Hypoxia, Brain; Kidney; Liver; Male; Myocardium; Nitroimidazoles; Rats; Rats, Sprague-Dawley | 2016 |
Correlation of FMISO simulations with pimonidazole-stained tumor xenografts: A question of O2 consumption?
Topics: Animals; Benzimidazoles; Carcinoma, Squamous Cell; Cell Line, Tumor; Computer Simulation; Feasibility Studies; Fluorescent Antibody Technique; Head and Neck Neoplasms; Humans; Hypoxia; Mice, Nude; Misonidazole; Models, Biological; Neoplasm Transplantation; Nitroimidazoles; Oxygen Consumption; Platelet Endothelial Cell Adhesion Molecule-1; Tumor Microenvironment | 2016 |
Engineered Breast Cancer Cell Spheroids Reproduce Biologic Properties of Solid Tumors.
Topics: Antineoplastic Agents; Biomarkers, Tumor; Cell Engineering; Cell Line, Tumor; Doxorubicin; Drug Resistance, Neoplasm; Extracellular Matrix Proteins; Female; Humans; Hypoxia; Neoplastic Stem Cells; Nitroimidazoles; Phosphoramide Mustards; Polymers; Prodrugs; Spheroids, Cellular; Triple Negative Breast Neoplasms | 2016 |
Silencing of galectin-1 inhibits retinal neovascularization and ameliorates retinal hypoxia in a murine model of oxygen-induced ischemic retinopathy.
Topics: Animals; Animals, Newborn; Blotting, Western; Disease Models, Animal; Galectin 1; Gene Silencing; Hypoxia; Intravitreal Injections; Ischemia; Mice; Mice, Inbred C57BL; Nitroimidazoles; Oxygen; Real-Time Polymerase Chain Reaction; Retinal Neovascularization; RNA; RNA, Messenger | 2017 |
Assessment of intratumor hypoxia by integrated 18F-FDG PET / perfusion CT in a liver tumor model.
Topics: Animals; Disease Models, Animal; Fluorodeoxyglucose F18; Glucose; Humans; Hypoxia; Liver Neoplasms; Male; Neovascularization, Pathologic; Nitroimidazoles; Oxygen Consumption; Perfusion; Positron Emission Tomography Computed Tomography; Positron-Emission Tomography; Rabbits | 2017 |
Imaging hypoxia in orthotopic rat liver tumors with iodine 124-labeled iodoazomycin galactopyranoside PET.
Topics: Animals; Carcinoma, Hepatocellular; Hypoxia; Image Processing, Computer-Assisted; Iodine Radioisotopes; Liver Neoplasms; Monosaccharides; Nitroimidazoles; Positron-Emission Tomography; Rats; Rats, Nude | 2008 |
Comparative pharmacokinetics, biodistribution, metabolism and hypoxia-dependent uptake of [18F]-EF3 and [18F]-MISO in rodent tumor models.
Topics: Animals; Fluorine Radioisotopes; Hypoxia; Male; Mice; Mice, Inbred C3H; Misonidazole; Neoplasms, Experimental; Nitroimidazoles; Radiopharmaceuticals; Tissue Distribution | 2008 |
Cellular uptake of PET tracers of glucose metabolism and hypoxia and their linkage.
Topics: Animals; Binding, Competitive; Biological Transport; Cell Count; Cell Line, Tumor; Female; Fluorodeoxyglucose F18; Glucose; Humans; Hypoxia; Mice; Neoplasms; Nitroimidazoles; Oxygen; Positron-Emission Tomography; Time Factors | 2008 |
[18F]EF3 is not superior to [18F]FMISO for PET-based hypoxia evaluation as measured in a rat rhabdomyosarcoma tumour model.
Topics: Animals; Autoradiography; Biomarkers; Heart; Hypoxia; Male; Misonidazole; Myocardium; Nitroimidazoles; Positron-Emission Tomography; Rats; Reference Values; Rhabdomyosarcoma; Tissue Distribution | 2009 |
On the isolation and evaluation of a novel unsubstituted 5-nitroimidazole derivative as an agent to target tumor hypoxia.
Topics: Animals; Antineoplastic Agents; Disease Models, Animal; Hypoxia; Mice; Molecular Structure; Neoplasms; Nitroimidazoles; Organotechnetium Compounds | 2008 |
Intratumoral spatial distribution of hypoxia and angiogenesis assessed by 18F-FAZA and 125I-gluco-RGD autoradiography.
Topics: Animals; Diagnostic Imaging; Glucosides; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Iodine Radioisotopes; Mice; Neoplasm Transplantation; Neovascularization, Pathologic; Nitroimidazoles; Oligopeptides; Radiopharmaceuticals; Research Design | 2008 |
Perindopril attenuates tubular hypoxia and inflammation in an experimental model of diabetic nephropathy in transgenic Ren-2 rats.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Female; Fibrosis; Hypoxia; Immunohistochemistry; Inflammation; Kidney Tubules; Macrophages; Nitroimidazoles; Osteopontin; Perindopril; Rats; Rats, Sprague-Dawley; Rats, Transgenic; Renin; Renin-Angiotensin System; Time Factors | 2008 |
Effect of artificial oxygen carrier with chemotherapy on tumor hypoxia and neovascularization.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Cisplatin; Cricetinae; HeLa Cells; Hemoglobins; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Mesocricetus; Microvessels; Neoplasms, Experimental; Neovascularization, Pathologic; Nitroimidazoles; Oxygen; Oxygen Inhalation Therapy; Polyethylene Glycols; Tumor Burden | 2008 |
Influence of PEG-conjugated hemoglobin on tumor oxygenation and response to chemotherapy.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Blood Substitutes; Cisplatin; Drug Synergism; Female; Hemoglobins; Hypoxia; Mice; Mice, Inbred BALB C; Nitroimidazoles; Oxygen Consumption; Polyethylene Glycols; Treatment Outcome; Uterine Cervical Neoplasms; Xenograft Model Antitumor Assays | 2008 |
Synthesis and biological evaluation of radioiodinated 2NUBTA as a cerebral ischemia marker.
Topics: Animals; Benzothiazoles; Biomarkers; Blood-Brain Barrier; Brain Ischemia; Cell Line, Tumor; Humans; Hypoxia; Iodine Radioisotopes; Mice; Models, Chemical; Nitroimidazoles; Radionuclide Imaging; Temperature; Thiazoles | 2009 |
Pimonidazole adduct immunohistochemistry in the rat kidney: detection of tissue hypoxia.
Topics: Animals; Hypoxia; Immunohistochemistry; Kidney; Molecular Structure; Nitroimidazoles; Rats; Tissue Fixation | 2009 |
Downregulation of matrix metalloprotease-9 and urokinase plasminogen activator by TX-1877 results in decreased tumor growth and metastasis on xenograft model of rectal cancer.
Topics: Animals; Cell Line, Tumor; Cell Proliferation; Down-Regulation; Female; Humans; Hypoxia; Lymphatic Metastasis; Matrix Metalloproteinase 2; Matrix Metalloproteinase 7; Matrix Metalloproteinase 9; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Nitroimidazoles; Radiation-Sensitizing Agents; Rats; Rectal Neoplasms; Reverse Transcriptase Polymerase Chain Reaction; Urokinase-Type Plasminogen Activator; X-Rays; Xenograft Model Antitumor Assays | 2009 |
Radio-copper-labeled Cu-ATSM: an indicator of quiescent but clonogenic cells under mild hypoxia in a Lewis lung carcinoma model.
Topics: Animals; Autoradiography; Bromodeoxyuridine; Carcinoma, Lewis Lung; Cell Proliferation; Colony-Forming Units Assay; Coordination Complexes; Copper Radioisotopes; Disease Models, Animal; Fluorodeoxyglucose F18; Hypoxia; Image Processing, Computer-Assisted; Immunohistochemistry; Ki-67 Antigen; Male; Mice; Nitroimidazoles; Organometallic Compounds; Positron-Emission Tomography; Staining and Labeling; Thiosemicarbazones | 2009 |
Increased hypoxia following vessel targeting in a murine model of retinoblastoma.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Carboplatin; Disease Models, Animal; Hypoxia; Mice; Mice, Transgenic; Microscopy, Confocal; Neovascularization, Pathologic; Nitroimidazoles; Pregnadienediols; Retinal Neoplasms; Retinoblastoma | 2009 |
Core needle biopsies for determination of the microenvironment in individual tumours for longitudinal radiobiological studies.
Topics: Animals; Biopsy, Needle; Carcinoma, Squamous Cell; Confidence Intervals; Disease Models, Animal; Dose Fractionation, Radiation; Dose-Response Relationship, Radiation; Environment; Female; Humans; Hypoxia; Immunohistochemistry; Longitudinal Studies; Male; Mice; Mice, Nude; Neoplasm Transplantation; Nitroimidazoles; Probability; Radiobiology; Random Allocation; Reference Values | 2009 |
Atrasentan (ABT-627) enhances perfusion and reduces hypoxia in a human tumor xenograft model.
Topics: Adenocarcinoma; Animals; Atrasentan; Colonic Neoplasms; Combined Modality Therapy; Etanidazole; Gadolinium DTPA; HT29 Cells; Humans; Hydrocarbons, Fluorinated; Hypoxia; Magnetic Resonance Imaging; Male; Mice; Mice, Nude; Nitroimidazoles; Perfusion; Pyrrolidines; Radiation-Sensitizing Agents; Radiotherapy; Treatment Outcome; Xenograft Model Antitumor Assays | 2009 |
Can hypoxia-PET map hypoxic cell density heterogeneity accurately in an animal tumor model at a clinically obtainable image contrast?
Topics: Animals; Carcinoma, Squamous Cell; Cell Count; Cell Hypoxia; Disease Models, Animal; Female; Hypoxia; Mice; Mice, Inbred C3H; Nitroimidazoles; Oxygen; Positron-Emission Tomography; Radiopharmaceuticals; Random Allocation; Sensitivity and Specificity; Tissue Distribution | 2009 |
Co-localisation of hypoxia and perfusion markers with parameters of glucose metabolism in human squamous cell carcinoma (hSCC) xenografts.
Topics: Animals; Benzimidazoles; Biomarkers, Tumor; Carcinoma, Squamous Cell; Cell Line, Tumor; Female; Fluorescent Dyes; Glucose; Humans; Hypoxia; Lactic Acid; Male; Mice; Mice, Nude; Microscopy, Fluorescence; Neoplasm Transplantation; Nitroimidazoles; Radiation-Sensitizing Agents; Transplantation, Heterologous | 2009 |
Nitroimidazole conjugates of bis(thiosemicarbazonato)64Cu(II) - Potential combination agents for the PET imaging of hypoxia.
Topics: Animals; Biological Transport; Cell Hypoxia; Cell Line, Tumor; Coordination Complexes; Copper Radioisotopes; Female; Hypoxia; Mammary Neoplasms, Animal; Mice; Mice, Inbred BALB C; Models, Chemical; Molecular Structure; Nitroimidazoles; Organometallic Compounds; Oxygen; Positron-Emission Tomography; Radiopharmaceuticals; Thiosemicarbazones; Tissue Distribution | 2010 |
Immunohistochemical detection of tumour hypoxia.
Topics: Animals; Glucose Transporter Type 1; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Mice; Neoplasms; Nitroimidazoles | 2010 |
Intrinsic susceptibility MR imaging of chemically induced rat mammary tumors: relationship to histologic assessment of hypoxia and fibrosis.
Topics: Animals; Biomarkers, Tumor; Carbon Dioxide; Female; Fibrosis; Hypoxia; Keratin-14; Linear Models; Magnetic Resonance Imaging; Mammary Neoplasms, Experimental; Methylnitrosourea; Necrosis; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents; Rats; Rats, Wistar | 2010 |
Release of nitrite from the antitubercular nitroimidazole drug PA-824 and analogues upon one-electron reduction in protic, non-aqueous solvent.
Topics: Aerobiosis; Antitubercular Agents; Electron Transport; Hypoxia; Mass Spectrometry; Mycobacterium tuberculosis; Nitriles; Nitrites; Nitrobenzenes; Nitroimidazoles; Pulse Radiolysis; Reactive Nitrogen Species; Solvents; Spectrophotometry, Ultraviolet; Water | 2010 |
Improved methodology for identifying the teratogenic potential in early drug development of hERG channel blocking drugs.
Topics: Abnormalities, Drug-Induced; Animals; Astemizole; Cetirizine; Drug Evaluation, Preclinical; Embryo Culture Techniques; Embryo, Mammalian; Embryonic Development; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Female; Heart Rate; Histamine H1 Antagonists, Non-Sedating; Hypoxia; Image Processing, Computer-Assisted; Maternal Exposure; Nitroimidazoles; Potassium Channels, Inwardly Rectifying; Pregnancy; Rats; Rats, Sprague-Dawley; Teratogens | 2010 |
Synthesis, radiofluorination, and hypoxia-selective studies of FRAZ: A configurational and positional analogue of the clinical hypoxia marker, [18F]-FAZA.
Topics: Antineoplastic Agents; Binding Sites; Biomarkers, Tumor; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Drug Screening Assays, Antitumor; Fluorine Radioisotopes; Humans; Hypoxia; Isotope Labeling; Nitroimidazoles; Positron-Emission Tomography; Ribose | 2010 |
Is (18)F-FDG a surrogate tracer to measure tumor hypoxia? Comparison with the hypoxic tracer (14)C-EF3 in animal tumor models.
Topics: Animals; Carbon Radioisotopes; Disease Models, Animal; Fiducial Markers; Fluorodeoxyglucose F18; Hypoxia; Male; Mice; Neoplasms; Nitroimidazoles; Radionuclide Imaging | 2010 |
High 18F-FDG uptake in microscopic peritoneal tumors requires physiologic hypoxia.
Topics: Air; Animals; Autoradiography; Biological Transport; Carbon Dioxide; Cell Proliferation; Female; Fluorescent Antibody Technique; Fluorodeoxyglucose F18; Gene Expression Regulation, Neoplastic; Glucose Transporter Type 1; HT29 Cells; Humans; Hypoxia; Mice; Nitroimidazoles; Oxygen; Peritoneal Neoplasms; Respiration | 2010 |
Targeting the multiple myeloma hypoxic niche with TH-302, a hypoxia-activated prodrug.
Topics: Animals; Apoptosis; Blotting, Western; Bone Marrow; Caspases; Cell Cycle; Cell Cycle Proteins; Cell Proliferation; Humans; Hypoxia; Male; Mice; Mice, Inbred C57BL; Multiple Myeloma; Neovascularization, Pathologic; Nitroimidazoles; Oxygen; Phosphoramide Mustards; Prodrugs; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A | 2010 |
PET of hypoxia with 89Zr-labeled cG250-F(ab')2 in head and neck tumors.
Topics: Animals; Antibodies, Monoclonal; Autoradiography; Carbonic Anhydrase Inhibitors; Head and Neck Neoplasms; Hypoxia; Image Processing, Computer-Assisted; Immunoglobulin Fab Fragments; Immunoglobulin G; Immunohistochemistry; Isotope Labeling; Mice; Mice, Inbred BALB C; Nitroimidazoles; Organometallic Compounds; Positron-Emission Tomography; Quality Control; Radiation-Sensitizing Agents; Radiopharmaceuticals; Tissue Distribution; Xenograft Model Antitumor Assays; Zirconium | 2010 |
Effect of cetuximab and fractionated irradiation on tumour micro-environment.
Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Carcinoma, Squamous Cell; Cell Line, Tumor; Cetuximab; Combined Modality Therapy; Dose Fractionation, Radiation; ErbB Receptors; Female; Gene Expression Regulation, Neoplastic; Humans; Hypoxia; Male; Mice; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents; Signal Transduction; Transplantation, Heterologous; Xenograft Model Antitumor Assays | 2010 |
Focal, periocular delivery of 2-deoxy-D-glucose as adjuvant to chemotherapy for treatment of advanced retinoblastoma.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Deoxyglucose; Disease Models, Animal; Drug Delivery Systems; Hypoxia; Mice; Mice, Transgenic; Microscopy, Fluorescence; Nitroimidazoles; Retinal Neoplasms; Retinoblastoma; Tumor Burden | 2010 |
Comparative study of tumor hypoxia by diffuse optical spectroscopy and immunohistochemistry in two tumor models.
Topics: Animals; Biomarkers, Tumor; Brain Neoplasms; Diffusion; Disease Models, Animal; Female; Hemoglobins; Hypoxia; Immunohistochemistry; Lymph Nodes; Male; Medical Oncology; Nitroimidazoles; Optical Devices; Oxygen; Radiation-Sensitizing Agents; Rats; Spectrum Analysis | 2010 |
Testing for hypoxia in forearm skin of patients with systemic sclerosis, assessed by pimonidazole.
Topics: Adult; Aged; Female; Forearm; Humans; Hypoxia; Male; Middle Aged; Nitroimidazoles; Radiation-Sensitizing Agents; Scleroderma, Systemic; Skin | 2010 |
Evaluation of renal hypoxia in diabetic mice by BOLD MRI.
Topics: Age Factors; Animals; Diabetic Nephropathies; Hypoxia; Magnetic Resonance Imaging; Male; Mice; Mice, Inbred C57BL; Nitroimidazoles; Oxygen; Staining and Labeling | 2010 |
Assessing hypoxia in animal tumor models based on pharmocokinetic analysis of dynamic FAZA PET.
Topics: Animals; Carcinoma, Squamous Cell; Female; Gingival Neoplasms; Humans; Hypoxia; Mice; Mice, Inbred C3H; Neoplasm Transplantation; Neoplasms; Nitroimidazoles; Positron-Emission Tomography; Transplantation, Heterologous; Tumor Cells, Cultured; Uterine Cervical Neoplasms | 2010 |
Identification and biological activities of a new antiangiogenic small molecule that suppresses mitochondrial reactive oxygen species.
Topics: Angiogenesis Inhibitors; Cell Hypoxia; Cell Line, Tumor; Cells, Cultured; Chorioallantoic Membrane; Humans; Hydrazones; Hypoxia; Mitochondria; Neovascularization, Physiologic; Nitroimidazoles; Reactive Oxygen Species; Small Molecule Libraries | 2011 |
In vivo identification and specificity assessment of mRNA markers of hypoxia in human and mouse tumors.
Topics: Animals; Biomarkers, Tumor; Carbonic Anhydrases; Cell Line, Tumor; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Glucose Transporter Type 1; Humans; Hypoxia; Mice; Mice, Inbred C3H; Mice, Inbred Strains; Mice, Nude; Neoplasms, Experimental; Nitroimidazoles; Positron-Emission Tomography; Protein-Lysine 6-Oxidase; Reproducibility of Results; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transplantation, Heterologous | 2011 |
Acetaminophen hepatotoxicity and HIF-1α induction in acetaminophen toxicity in mice occurs without hypoxia.
Topics: Acetaminophen; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Cyclosporine; Dose-Response Relationship, Drug; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Immunosuppressive Agents; Male; Mice; Mice, Inbred C57BL; Mitochondria, Liver; Nitroimidazoles; Oxidative Stress; Statistics, Nonparametric | 2011 |
Detection of hypoxia by [18F]EF5 in atherosclerotic plaques in mice.
Topics: Analysis of Variance; Animals; Aorta; Apolipoprotein B-100; Atherosclerosis; Autoradiography; Disease Models, Animal; Etanidazole; Female; Fluorine Radioisotopes; Genotype; Hydrocarbons, Fluorinated; Hypoxia; Immunohistochemistry; Insulin-Like Growth Factor II; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitroimidazoles; Phenotype; Positron-Emission Tomography; Radiopharmaceuticals; Receptors, LDL; Tissue Distribution | 2011 |
Measuring tumor hypoxia with ¹⁸F-FETNIM PET in esophageal squamous cell carcinoma: a pilot clinical study.
Topics: Carcinoma, Squamous Cell; Chemoradiotherapy; Esophageal Neoplasms; Female; Fluorine Radioisotopes; Humans; Hypoxia; Logistic Models; Male; Middle Aged; Multimodal Imaging; Nitroimidazoles; Oxygen; Pilot Projects; Positron-Emission Tomography; Predictive Value of Tests; Radiopharmaceuticals; ROC Curve; Tomography, X-Ray Computed; Treatment Outcome | 2012 |
Mycobacterium tuberculosis infection induces hypoxic lung lesions in the rat.
Topics: Animals; Disease Models, Animal; Female; Granuloma; Hypoxia; Immunohistochemistry; Lung; Mycobacterium tuberculosis; Nitroimidazoles; Rats; Tuberculosis, Pulmonary | 2011 |
CNS hypoxia is more pronounced in murine cerebral than noncerebral malaria and is reversed by erythropoietin.
Topics: Animals; Brain; Disease Models, Animal; Erythropoietin; Female; Fluorescent Dyes; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Malaria, Cerebral; Mice; Nitroimidazoles; Parasitemia; Plasmodium berghei; Poly(ADP-ribose) Polymerases; Survival Analysis; Treatment Outcome | 2011 |
Preparation of nucleosides derived from 2-nitroimidazole and D-arabinose, D-ribose, and D-galactose by the Vorbrüggen method and their conversion to potential precursors for tracers to image hypoxia.
Topics: Acetonitriles; Animals; Arabinose; Galactose; Humans; Hypoxia; Isomerism; Magnetic Resonance Spectroscopy; Molecular Imaging; Neoplasms; Nitroimidazoles; Nucleosides; Radioactive Tracers; Ribose; Silanes | 2011 |
Pharmacokinetics of TH-302: a hypoxically activated prodrug of bromo-isophosphoramide mustard in mice, rats, dogs and monkeys.
Topics: Administration, Oral; Animals; Dogs; Drug Evaluation, Preclinical; Female; Half-Life; Humans; Hypoxia; Infusions, Intravenous; Injections, Intraperitoneal; Injections, Intravenous; Macaca fascicularis; Male; Mice; Mice, Inbred Strains; Mice, Nude; Molecular Structure; Nitroimidazoles; Phosphoramide Mustards; Predictive Value of Tests; Prodrugs; Rats; Rats, Sprague-Dawley; Species Specificity; Tissue Distribution | 2012 |
Liposomal doxorubicin improves radiotherapy response in hypoxic prostate cancer xenografts.
Topics: Animals; Antibiotics, Antineoplastic; Cell Line, Tumor; Combined Modality Therapy; Contrast Media; Doxorubicin; Humans; Hypoxia; Immunohistochemistry; Magnetic Resonance Imaging; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Models, Theoretical; Neoplasm Transplantation; Nitroimidazoles; Prostatic Neoplasms; Treatment Outcome | 2011 |
Significant impact of different oxygen breathing conditions on noninvasive in vivo tumor-hypoxia imaging using [¹⁸F]-fluoro-azomycinarabino-furanoside ([¹⁸F]FAZA).
Topics: Animals; Cell Hypoxia; Diagnostic Imaging; Fluorine Radioisotopes; Hypoxia; Image Processing, Computer-Assisted; Immunohistochemistry; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Neoplasms, Experimental; Nitroimidazoles; Oxygen; Positron-Emission Tomography; Radiopharmaceuticals; Respiration; Ribose | 2011 |
Effect of a second nitroimidazole redox centre on the accumulation of a hypoxia marker: synthesis and in vitro evaluation of 99mTc-labeled bisnitroimidazole propylene amine oxime complexes.
Topics: Alkenes; Amines; Animals; Cell Line; Cell Line, Tumor; Chromatography, High Pressure Liquid; Hypoxia; Mice; Models, Chemical; Nitroimidazoles; Oxidation-Reduction; Oximes; Technetium; Time Factors | 2012 |
Mouse model of necrotic tuberculosis granulomas develops hypoxic lesions.
Topics: Animals; Antitubercular Agents; Aza Compounds; Disease Models, Animal; Fluoroquinolones; Gene Expression Profiling; Genes, Bacterial; Granuloma; Hypoxia; Immunohistochemistry; Male; Mice; Mice, Inbred C3H; Moxifloxacin; Mycobacterium tuberculosis; Nitroimidazoles; Positron-Emission Tomography; Pyrazinamide; Quinolines; Treatment Outcome; Tuberculosis | 2012 |
Conductive thermal ablation of 4T1 murine breast carcinoma reduces severe hypoxia in surviving tumour.
Topics: Animals; Combined Modality Therapy; Female; Hyperthermia, Induced; Hypoxia; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Nitroimidazoles; Radiation-Sensitizing Agents | 2012 |
Operable non-small cell lung cancer: correlation of volumetric helical dynamic contrast-enhanced CT parameters with immunohistochemical markers of tumor hypoxia.
Topics: Aged; Biomarkers, Tumor; Blood Volume; Carcinoma, Non-Small-Cell Lung; Contrast Media; Female; Humans; Hypoxia; Immunohistochemistry; Iohexol; Lung Neoplasms; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Grading; Neoplasm Staging; Nitroimidazoles; Prospective Studies; Radiation-Sensitizing Agents; Radiographic Image Interpretation, Computer-Assisted; Statistics, Nonparametric; Tomography, Spiral Computed | 2012 |
Hypoxia imaging of uterine cervix carcinoma with (18)F-FETNIM PET/CT.
Topics: Adult; Aged; Disease-Free Survival; Female; Fluorodeoxyglucose F18; Humans; Hypoxia; Imaging, Three-Dimensional; Middle Aged; Multimodal Imaging; Nitroimidazoles; Positron-Emission Tomography; Tomography, X-Ray Computed; Uterine Cervical Neoplasms | 2012 |
Activation of AKT by hypoxia: a potential target for hypoxic tumors of the head and neck.
Topics: Animals; Blotting, Western; Carcinoma, Squamous Cell; Cell Hypoxia; Cell Line, Tumor; Cell Survival; Combined Modality Therapy; ErbB Receptors; Fluorescent Antibody Technique; Head and Neck Neoplasms; Heterocyclic Compounds, 3-Ring; Humans; Hypoxia; Mice; Mice, Inbred BALB C; Mice, Nude; Nitroimidazoles; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Radiation-Sensitizing Agents; Radiotherapy; Receptor, ErbB-2; Signal Transduction; Tumor Microenvironment; Xenograft Model Antitumor Assays | 2012 |
PET hypoxia imaging with FAZA: reproducibility at baseline and during fractionated radiotherapy in tumour-bearing mice.
Topics: Animals; Body Weight; Cell Line, Tumor; Collagen; Dose Fractionation, Radiation; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Combinations; Female; Fluorine Radioisotopes; Humans; Hypoxia; Image Processing, Computer-Assisted; Laminin; Mice; Mice, Nude; Neoplasm Transplantation; Nitroimidazoles; Positron-Emission Tomography; Proteoglycans; Radiotherapy; Uterine Cervical Neoplasms | 2013 |
Chronic activation of vasopressin V2 receptor signalling lowers renal medullary oxygen levels in rats.
Topics: Animals; Deamino Arginine Vasopressin; Disease Models, Animal; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Kidney Medulla; Nitroimidazoles; Oxygen; Rats; Rats, Brattleboro; Rats, Sprague-Dawley; Receptors, Vasopressin; Signal Transduction; Vasopressins | 2013 |
Determination of organ-specific anemia tolerance.
Topics: Acute Disease; Anemia; Animals; Brain; Cell Hypoxia; Female; Hemodilution; Hemodynamics; Hypoxia; Hypoxia, Brain; Immune Tolerance; Intestine, Small; Kidney; Liver; Male; Muscle, Skeletal; Nitroimidazoles; Oxygen Consumption; Random Allocation; Swine; Vascular Endothelial Growth Factor A | 2013 |
Validation of the fluorinated 2-nitroimidazole SR-4554 as a noninvasive hypoxia marker detected by magnetic resonance spectroscopy.
Topics: Animals; Biomarkers, Tumor; Chromatography, High Pressure Liquid; Drug Evaluation, Preclinical; Female; Fluorine Radioisotopes; Hypoxia; Magnetic Resonance Spectroscopy; Mice; Mice, SCID; Neoplasm Transplantation; Neoplasms, Experimental; Nitroimidazoles; Oxygen; Polarography; Rats; Tissue Distribution | 2002 |
Chronic renal hypoxia after acute ischemic injury: effects of L-arginine on hypoxia and secondary damage.
Topics: Acute Kidney Injury; Animals; Arginine; Chronic Disease; Disease Progression; Hypoxia; Ischemia; Kidney; Kidney Diseases; Kidney Failure, Chronic; Male; Nephrectomy; Nitroimidazoles; Rats; Rats, Sprague-Dawley; Renal Circulation; Reperfusion Injury; Time Factors | 2003 |
Microwave-assisted (radio)halogenation of nitroimidazole-based hypoxia markers.
Topics: Biomarkers; Hot Temperature; Humans; Hypoxia; Iodine Radioisotopes; Isotope Labeling; Microwaves; Nitroimidazoles; Radiochemistry; Radionuclide Imaging; Radiopharmaceuticals | 2002 |
HIF-1A, pimonidazole, and iododeoxyuridine to estimate hypoxia and perfusion in human head-and-neck tumors.
Topics: Carcinoma, Squamous Cell; Dimerization; Dose-Response Relationship, Drug; Head and Neck Neoplasms; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Idoxuridine; Immunohistochemistry; Ki-67 Antigen; Neovascularization, Pathologic; Nitroimidazoles; Nucleic Acid Synthesis Inhibitors; Perfusion; Transcription Factors; Treatment Outcome | 2002 |
A novel hypoxia-dependent 2-nitroimidazole KIN-841 inhibits tumour-specific angiogenesis by blocking production of angiogenic factors.
Topics: Angiogenesis Inhibitors; Animals; Carcinoma, Lewis Lung; Cattle; Cell Division; Chick Embryo; Chorion; Endothelial Growth Factors; Endothelium, Vascular; Enzyme-Linked Immunosorbent Assay; Hydroxamic Acids; Hypoxia; Imidazoles; Injections, Intraperitoneal; Intercellular Signaling Peptides and Proteins; Lung Neoplasms; Lymphokines; Mice; Neovascularization, Pathologic; Nitro Compounds; Nitroimidazoles; Pulmonary Artery; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2003 |
Cellular responses to hypoxia after renal segmental infarction.
Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Cell Division; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Infarction; Kidney; Male; Nitroimidazoles; Rats; Rats, Sprague-Dawley; Renal Circulation; Trans-Activators; Transcription Factors; Vascular Endothelial Growth Factor A | 2003 |
Hypoxia and differentiation in squamous cell carcinomas of the uterine cervix: pimonidazole and involucrin.
Topics: Biopsy; Carcinoma, Squamous Cell; Cell Differentiation; Cell Line, Tumor; Female; Humans; Hypoxia; Immunohistochemistry; In Situ Hybridization; Metallothionein; Nitroimidazoles; Oxygen; Prognosis; Protein Precursors; Radiation-Sensitizing Agents; RNA, Messenger; Transcription, Genetic; Uterine Cervical Neoplasms | 2003 |
TNP-470 promotes initial vascular sprouting in xenograft tumors.
Topics: Angiogenesis Inhibitors; Angiography; Animals; Antibiotics, Antineoplastic; Apoptosis; Capillaries; Cell Line, Tumor; Cyclohexanes; Fluorescein; Humans; Hypoxia; Immunohistochemistry; In Situ Hybridization; In Situ Nick-End Labeling; Lectins; Mice; Mice, Nude; Microcirculation; Neoplasm Transplantation; Neoplasms; Neovascularization, Pathologic; Nitroimidazoles; O-(Chloroacetylcarbamoyl)fumagillol; Radiation-Sensitizing Agents; Sesquiterpenes; Vascular Endothelial Growth Factor A; Wilms Tumor | 2004 |
Differentiation-associated staining with anti-pimonidazole antibodies in head and neck tumors.
Topics: Antibodies, Anti-Idiotypic; Biomarkers; Carcinoma, Squamous Cell; Flow Cytometry; Frozen Sections; Head and Neck Neoplasms; Humans; Hypoxia; NAD(P)H Dehydrogenase (Quinone); NADPH-Ferrihemoprotein Reductase; Nitroimidazoles; Prognosis; Radiation-Sensitizing Agents; Staining and Labeling | 2004 |
Propargylic sulfones possessing a 2-nitroimidazole function: novel hypoxic-cell radiosensitizers with intracellular non-protein thiol depletion ability.
Topics: Alkynes; Cell Line, Tumor; Cell Survival; Glutathione; Humans; Hydrophobic and Hydrophilic Interactions; Hypoxia; Isatin; Kinetics; Nitroimidazoles; Radiation-Sensitizing Agents; Structure-Activity Relationship; Sulfhydryl Compounds | 2004 |
Hypoxia-inducible factor 1alpha expression as an intrinsic marker of hypoxia: correlation with tumor oxygen, pimonidazole measurements, and outcome in locally advanced carcinoma of the cervix.
Topics: Antigens, Neoplasm; Biomarkers, Tumor; Carbonic Anhydrase IX; Carbonic Anhydrases; Disease-Free Survival; Female; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Ion-Selective Electrodes; Middle Aged; Neoplasm Recurrence, Local; Nitroimidazoles; Oxygen; Prognosis; Radiation-Sensitizing Agents; Survival Rate; Transcription Factors; Treatment Outcome; Uterine Cervical Neoplasms | 2004 |
Hypoxia in the androgen-dependent Shionogi model for prostate cancer at three stages.
Topics: Androgens; Animals; Cell Line, Tumor; Disease Models, Animal; Disease Progression; Flow Cytometry; Hypoxia; Image Cytometry; Male; Mammary Neoplasms, Animal; Mice; Neoplasm Transplantation; Neoplasms, Experimental; Neoplasms, Hormone-Dependent; Nitroimidazoles; Prognosis; Prostatic Neoplasms; Protein Binding; Time Factors; Tumor Burden | 2004 |
Erythropoietin and erythropoietin receptor expression in head and neck cancer: relationship to tumor hypoxia.
Topics: Disease-Free Survival; Erythropoietin; Head and Neck Neoplasms; Humans; Hypoxia; Immunohistochemistry; Ligands; Nitroimidazoles; Prognosis; Radiation-Sensitizing Agents; Receptors, Erythropoietin; Recombinant Proteins; Time Factors | 2005 |
[Development of [18F]FRP-170 injection for imaging hypoxia by PET].
Topics: Animals; Dosage Forms; Drug Design; Fluorine Radioisotopes; Hypoxia; Injections, Intravenous; Mice; Mice, Inbred Strains; Mutagenicity Tests; Nitroimidazoles; Positron-Emission Tomography; Radiation Dosage; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Tissue Distribution | 2005 |
Tirapazamine administered as a neoadjuvant to radiotherapy reduces metastatic dissemination.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Combined Modality Therapy; Female; Hypoxia; Mice; Mice, Inbred C3H; Neoadjuvant Therapy; Neoplasm Metastasis; Neoplasm Transplantation; Neovascularization, Pathologic; Nitroimidazoles; Radiation-Sensitizing Agents; Sarcoma, Experimental; Tirapazamine; Treatment Outcome; Triazines | 2005 |
Inhibition of mitochondrial respiration elevates oxygen concentration but leaves regulation of hypoxia-inducible factor (HIF) intact.
Topics: Active Transport, Cell Nucleus; Cell Line, Tumor; Cell Nucleus; DNA, Mitochondrial; Electron Transport; Fluorescent Dyes; Gene Expression Regulation; Humans; Hypoxia; Microscopy, Fluorescence; Mitochondria; Models, Theoretical; Nitroimidazoles; Osteosarcoma; Oxygen; Oxygen Consumption; Vascular Endothelial Growth Factor A | 2005 |
Role of the hypoxic bone marrow microenvironment in 5T2MM murine myeloma tumor progression.
Topics: Animals; Apoptosis; Bone Marrow Cells; Caspase 3; Caspases; Cell Hypoxia; Disease Progression; Flow Cytometry; Hematopoiesis; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Leukocyte Common Antigens; Mice; Multiple Myeloma; Neovascularization, Pathologic; Nitroimidazoles | 2005 |
A novel [99mTc[triple bond]N]2+ complex of metronidazole xanthate as a potential agent for targeting hypoxia.
Topics: Animals; Hypoxia; Imidazoles; Ligands; Metronidazole; Mice; Molecular Structure; Neoplasm Transplantation; Neoplasms, Experimental; Nitroimidazoles; Organotechnetium Compounds; Radionuclide Imaging; Radiopharmaceuticals; Structure-Activity Relationship; Time Factors; Tissue Distribution | 2005 |
Modulation of intratumoral hypoxia by the epidermal growth factor receptor inhibitor gefitinib detected using small animal PET imaging.
Topics: Animals; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; ErbB Receptors; Fluorine Radioisotopes; Gefitinib; Humans; Hypoxia; Lung Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Nitroimidazoles; Oxidation-Reduction; Oxygen; Positron-Emission Tomography; Quinazolines; Tissue Distribution | 2005 |
Ischemic acute renal failure induces the expression of a wide range of nephrogenic proteins.
Topics: Acute Kidney Injury; Animals; Biomarkers; Bone Morphogenetic Protein 7; Bone Morphogenetic Proteins; Carrier Proteins; Caspase 3; Caspases; Cell Death; Hypoxia; Immunohistochemistry; Kidney; Kidney Tubules; Male; Nitroimidazoles; Phosphorylation; Rats; Rats, Sprague-Dawley; Regeneration; Reperfusion Injury; Smad Proteins | 2006 |
Hypoxia-inducible factors and tubular cell survival in isolated perfused kidneys.
Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Cell Survival; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; In Vitro Techniques; Kidney Cortex; Kidney Medulla; Kidney Tubules, Collecting; Nitroimidazoles; Oxygen; Perfusion; Rats; Up-Regulation | 2006 |
Evaluation of 99mTc(CO)3 complex of 2-methyl-5-nitroimidazole as an agent for targeting tumor hypoxia.
Topics: Animals; Drug Carriers; Drug Stability; Fibrosarcoma; Hypoxia; Ligands; Mice; Neoplasms; Nitroimidazoles; Organotechnetium Compounds; Tissue Distribution | 2006 |
Oxygen status of lung granulomas in Mycobacterium tuberculosis-infected mice.
Topics: Animals; Biomarkers; Disease Models, Animal; Electrodes; Female; Granuloma; Hypoxia; Immunohistochemistry; Lung; Mice; Mice, Inbred C57BL; Mutation; Mycobacterium tuberculosis; Necrosis; Nitrates; Nitroimidazoles; Oxygen; Time Factors; Tuberculosis, Pulmonary | 2006 |
Rod photoreceptor loss in Rho-/- mice reduces retinal hypoxia and hypoxia-regulated gene expression.
Topics: Animals; Apyrase; Cyclic Nucleotide Phosphodiesterases, Type 6; Dark Adaptation; Diltiazem; Enzyme-Linked Immunosorbent Assay; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Light; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitroimidazoles; Oxygen Consumption; Phosphoric Diester Hydrolases; Retinal Degeneration; Retinal Rod Photoreceptor Cells; Retinal Vessels; Reverse Transcriptase Polymerase Chain Reaction; Rhodopsin; RNA, Messenger; Transcriptional Activation; Vascular Endothelial Growth Factor A | 2006 |
Age-related hearing loss in CD/1 mice is associated to ROS formation and HIF target proteins up-regulation in the cochlea.
Topics: Action Potentials; Aging; Animals; Apoptosis; Caspase 3; Cochlea; Cochlear Nerve; Coloring Agents; Hearing Loss; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Injections, Intravenous; Insulin-Like Growth Factor I; Mice; Nitroimidazoles; Reactive Oxygen Species; Schwann Cells; Spiral Ganglion; Tumor Necrosis Factor-alpha; Tumor Suppressor Protein p53; Up-Regulation | 2007 |
Determination of tumour hypoxia with the PET tracer [18F]EF3: improvement of the tumour-to-background ratio in a mouse tumour model.
Topics: Animals; Area Under Curve; Hypoxia; Liver; Male; Mice; Mice, Inbred C3H; Neoplasms; Nitroimidazoles; Ornidazole; Positron-Emission Tomography; Radiopharmaceuticals; Spironolactone; Time Factors; Tissue Distribution; Treatment Outcome | 2007 |
Improved cryosections and specific immunohistochemical methods for detecting hypoxia in mouse and rat cochleae.
Topics: Animals; Animals, Outbred Strains; Biomarkers; Cochlear Diseases; Fluorescent Antibody Technique, Indirect; Frozen Sections; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Mice; Nitroimidazoles; Rats; Rats, Sprague-Dawley; Tissue Embedding | 2007 |
Distribution of hematopoietic stem cells in the bone marrow according to regional hypoxia.
Topics: Animals; Benzimidazoles; Bone Marrow Cells; Cell Differentiation; Hematopoietic Stem Cells; Hematopoietic System; Hypoxia; Mice; Mice, Inbred C57BL; Nitroimidazoles; Oxygen; Perfusion; Stem Cells; Tirapazamine; Triazines | 2007 |
Location of persisting mycobacteria in a Guinea pig model of tuberculosis revealed by r207910.
Topics: Animals; Antibiotics, Antitubercular; Antitubercular Agents; Colony Count, Microbial; Diarylquinolines; Female; Granuloma; Guinea Pigs; Hypoxia; Isoniazid; Lung; Mycobacterium tuberculosis; Nitroimidazoles; Pyrazinamide; Quinolines; Radiation-Sensitizing Agents; Rifampin; Spleen; Tuberculosis | 2007 |
Tumor hypoxia imaging with [F-18] fluoronitroimidazole in non-small-cell lung cancer.
Topics: Aged; Carcinoma, Non-Small-Cell Lung; Diagnosis, Differential; Female; Humans; Hypoxia; Lung Neoplasms; Male; Nitroimidazoles; Reproducibility of Results; Retrospective Studies; Tomography, Emission-Computed, Single-Photon; Tomography, X-Ray Computed | 2007 |
Development of cytosolic hypoxia and hypoxia-inducible factor stabilization are facilitated by aquaporin-1 expression.
Topics: Animals; Aquaporin 1; Carbon Dioxide; Cell Membrane; Cytosol; Gene Expression Regulation; Hypoxia; Hypoxia-Inducible Factor 1; Lung; Microscopy, Confocal; Models, Biological; Nitroimidazoles; Oxygen; PC12 Cells; Permeability; Rats; Up-Regulation | 2007 |
Immunohistochemical detection of hypoxia in mouse liver tissues treated with pimonidazole using "in vivo cryotechnique".
Topics: Animals; Cryopreservation; Freeze Substitution; Hypoxia; Immunohistochemistry; Injections, Intraperitoneal; Liver; Mice; Mice, Inbred C57BL; Nitroimidazoles; Tissue Fixation | 2007 |
Effects of old age on hepatocyte oxygenation.
Topics: Aging; Animals; Biomarkers; Hepatocytes; Hypoxia; Male; Mitochondria; Nitroimidazoles; Oxygen; Oxygen Consumption; Rats; Rats, Inbred F344 | 2007 |
Tumor hypoxia imaging in orthotopic liver tumors and peritoneal metastasis: a comparative study featuring dynamic 18F-MISO and 124I-IAZG PET in the same study cohort.
Topics: Animals; Disease Models, Animal; Half-Life; Hypoxia; Liver Neoplasms, Experimental; Misonidazole; Monosaccharides; Nitroimidazoles; Peritoneal Neoplasms; Positron-Emission Tomography; Rats; Tissue Distribution | 2008 |
Adaptation to hypoxia in the diabetic rat kidney.
Topics: Adaptation, Physiological; Animals; Antioxidants; Basic Helix-Loop-Helix Transcription Factors; Cyclic N-Oxides; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Glomerular Filtration Rate; Heme Oxygenase-1; Hypoxia; Hypoxia-Inducible Factor 1; Insulin; Male; Nitroimidazoles; Rats; Rats, Inbred Strains; Spin Labels; Streptozocin | 2008 |
Measurement of hypoxia using invasive oxygen-sensitive electrode, pimonidazole binding and 18F-FDG uptake in anaemic or erythropoietin-treated mice bearing human glioma xenografts.
Topics: Anemia; Animals; Autoradiography; Electrodes; Erythropoietin; Fluorodeoxyglucose F18; Glioma; Hemoglobins; Humans; Hypoxia; Mice; Mice, Nude; Muscle, Skeletal; Neoplasm Transplantation; Nitroimidazoles; Recombinant Proteins; Transplantation, Heterologous | 2008 |
Tuberculous granulomas are hypoxic in guinea pigs, rabbits, and nonhuman primates.
Topics: Animals; Antitubercular Agents; Disease Models, Animal; Granuloma; Guinea Pigs; Humans; Hypoxia; Immunohistochemistry; Lung; Macaca fascicularis; Metronidazole; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mycobacterium tuberculosis; Nitroimidazoles; Oxygen; Rabbits; Radiation-Sensitizing Agents; Tuberculosis, Pulmonary | 2008 |
Hypoxia, hypoxia-inducible transcription factor, and macrophages in human atherosclerotic plaques are correlated with intraplaque angiogenesis.
Topics: Aged; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Biomarkers; Carotid Stenosis; Cross-Sectional Studies; Disease Progression; Endarterectomy, Carotid; Female; Humans; Hypoxia; Hypoxia-Inducible Factor 1; Immunohistochemistry; Macrophages; Male; Middle Aged; Neovascularization, Pathologic; Nitroimidazoles; Oxidative Stress; RNA, Messenger; Vascular Endothelial Growth Factor A | 2008 |
The paradox of hypoxic and oxidative stress in atherosclerosis.
Topics: Antigens, CD; Antigens, Differentiation, Myelomonocytic; Atherosclerosis; Biomarkers; Humans; Hypoxia; Hypoxia-Inducible Factor 1; Macrophages; Neovascularization, Pathologic; Nitroimidazoles; Oxidative Stress; Reactive Oxygen Species | 2008 |
Hypoxia-enhanced reduction and covalent binding of [2-3H]misonidazole in the perfused rat liver.
Topics: Animals; DNA; Glutathione; Hypoxia; Liver; Male; Misonidazole; Nitroimidazoles; Oxidation-Reduction; Oxygen; Perfusion; Protein Binding; Rats; Rats, Inbred Strains; RNA | 1984 |
Factors associated with the preincubation effect of hypoxic cell sensitizers in vitro and their possible implications in chemosensitization.
Topics: Animals; Cell Survival; Cells, Cultured; Cricetinae; Cysteamine; Dose-Response Relationship, Drug; Drug Resistance; Etanidazole; Hydrogen Peroxide; Hyperthermia, Induced; Hypoxia; Melphalan; Nitroimidazoles; Radiation Tolerance; Radiation-Sensitizing Agents; Time Factors | 1984 |
Sensitising effect of misonidazole on NHIK 1922 cells irradiated in vitro or as solid tumour in athymic nude mice.
Topics: Animals; Cell Line; Cell Survival; Colony-Forming Units Assay; Dose-Response Relationship, Drug; Hypoxia; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Misonidazole; Neoplasms, Experimental; Nitroimidazoles; Radiation-Protective Agents | 1981 |
Influence of misonidazole on survival of wild-type and radiosensitive mutants of yeast.
Topics: Dose-Response Relationship, Drug; Gamma Rays; Haploidy; Hypoxia; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents; Saccharomyces cerevisiae | 1983 |
The effect of a hypoxic cell sensitizer on cancer radiotherapy: an analysis by a model.
Topics: Humans; Hypoxia; Mathematics; Misonidazole; Models, Theoretical; Neoplasms; Nitroimidazoles | 1984 |
Radiosensitizing drugs in relation to individualized treatment.
Topics: Alkylating Agents; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Humans; Hypoxia; In Vitro Techniques; Misonidazole; Neoplasms; Nervous System; Nitroimidazoles; Radiation Tolerance; Radiation-Sensitizing Agents; Sulfhydryl Reagents | 1984 |
Polarographic measurement of misonidazole in mouse mammary tumors.
Topics: Animals; Half-Life; Hypoxia; In Vitro Techniques; Male; Mammary Neoplasms, Experimental; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Polarography; Tissue Distribution | 1984 |
[Radiosensitization of hypoxic tumor cells with special reference to head and neck cancers].
Topics: Half-Life; Head and Neck Neoplasms; Humans; Hypoxia; Misonidazole; Nitroimidazoles; Radiation Tolerance; Radiation-Sensitizing Agents | 1983 |
Role of glutathione in the hypoxic cell cytotoxicity of misonidazole.
Topics: Animals; Antineoplastic Agents; Cell Line; Cell Survival; Cricetinae; Cricetulus; Female; Glutathione; Glutathione Transferase; Hypoxia; Maleates; Misonidazole; Nitroimidazoles; Ovary | 1983 |
Influence of hypoxia on the metabolism and excretion of misonidazole by the isolated perfused rat liver--a model system.
Topics: Animals; Chromatography, High Pressure Liquid; Hypoxia; Kinetics; Liver; Male; Misonidazole; Nitroimidazoles; Rats | 1983 |
Reduction of misonidazole and its derivatives by xanthine oxidase.
Topics: Hypoxia; In Vitro Techniques; Misonidazole; Nitroimidazoles; Oxidation-Reduction; Xanthine Oxidase | 1981 |
Comparative misonidazole metabolism in anaerobic bacteria and hypoxic Chinese hamster lung fibroblast (V-79-473) cells.
Topics: Animals; Biotransformation; Cells, Cultured; Cricetinae; Enterobacteriaceae; Fibroblasts; Hypoxia; Lung; Mesocricetus; Misonidazole; Mutagens; Nitroimidazoles; Oxidation-Reduction | 1982 |
Radiosensitizing ability and cytotoxicity of some 5(4)-substituted 2-methyl-4(5)-nitroimidazoles.
Topics: Animals; Cell Survival; Cricetinae; Hypoxia; In Vitro Techniques; Nitroimidazoles; Radiation-Sensitizing Agents; Structure-Activity Relationship | 1982 |
The interaction of misonidazole with radiation, chemotherapeutic agents, or heat: a preliminary report.
Topics: Animals; Antineoplastic Agents; Cell Survival; Cells, Cultured; Cisplatin; Cricetinae; Hot Temperature; Hypoxia; Mechlorethamine; Melphalan; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents | 1980 |
Radiation-enhanced cytotoxicity of misonidazole.
Topics: Animals; Cell Line; Cell Survival; Cricetinae; Cricetulus; Female; Hypoxia; Misonidazole; Nitroimidazoles; Ovary; X-Rays | 1981 |
Combined effects of misonidazole radiosensitization and hypoxic cell toxicity in mammalian cells.
Topics: Animals; Cell Line; Cell Survival; Cricetinae; Cricetulus; Female; Hypoxia; Misonidazole; Nitroimidazoles; Ovary; X-Rays | 1981 |
The effect of combinations of nitroaromatic and nitroxyl radiosensitizers on the radiation survival response of Chinese hamster cells, V.79-753B, in vitro.
Topics: Acetophenones; Animals; Cell Line; Cell Survival; Cricetinae; Cricetulus; Cyclic N-Oxides; Female; Hypoxia; Misonidazole; Nitroimidazoles; Ovary; Radiation-Sensitizing Agents; Spin Labels | 1981 |
Testing of hypoxic cell radiosensitizers in vivo.
Topics: Animals; Cell Survival; Dose-Response Relationship, Drug; Humans; Hypoxia; Mice; Misonidazole; Neoplasms, Experimental; Nitroimidazoles; Radiation-Sensitizing Agents | 1980 |
Cytotoxic and radiosensitizing effects of misonidazole on hematopoiesis in normal and tumor-bearing mice.
Topics: Animals; Colony-Forming Units Assay; Dose-Response Relationship, Radiation; Hematopoiesis; Hematopoietic Stem Cells; Hypoxia; Lung Neoplasms; Male; Mice; Misonidazole; Neoplasms, Experimental; Nitroimidazoles | 1980 |
Detecting hypoxia in heart using phosphorescence quenching and 99mtechnetium-nitroimidazoles.
Topics: Animals; Cardiomyopathies; Disease Models, Animal; Dogs; Hypoxia; Luminescent Measurements; Myocardial Ischemia; Myocardium; Nitroimidazoles; Organotechnetium Compounds; Oxygen; Radionuclide Imaging | 1994 |
Potential of nitroimidazoles as markers of hypoxia in heart.
Topics: Animals; Biomarkers; Dogs; Hypoxia; In Vitro Techniques; Myocardium; Nitroimidazoles; Organotechnetium Compounds; Oxygen Consumption; Rats; Rats, Sprague-Dawley | 1994 |
An enzyme-linked immunosorbent assay for hypoxia marker binding in tumours.
Topics: Animals; Biomarkers, Tumor; Calibration; Dogs; Enzyme-Linked Immunosorbent Assay; Hypoxia; Neoplasms; Nitroimidazoles; Tissue Distribution; Tritium | 1994 |
TcO(PnA.O-1-(2-nitroimidazole)) [BMS-181321], a new technetium-containing nitroimidazole complex for imaging hypoxia: synthesis, characterization, and xanthine oxidase-catalyzed reduction.
Topics: Chromatography, High Pressure Liquid; Crystallization; Crystallography, X-Ray; Dimethylformamide; Electrochemistry; Hypoxia; Kinetics; Magnetic Resonance Spectroscopy; Molecular Structure; Nitroimidazoles; Organotechnetium Compounds; Radionuclide Imaging; Stereoisomerism; Xanthine Oxidase | 1994 |
A novel [99m]technetium-labeled nitroheterocycle capable of identification of hypoxia in heart.
Topics: Animals; Heart; Hypoxia; Male; Mitochondria, Heart; Molecular Structure; Myocardium; Nitroimidazoles; Organotechnetium Compounds; Radionuclide Imaging; Rats; Rats, Sprague-Dawley; Technetium | 1993 |
Effects of low flow and hypoxia on myocardial retention of technetium-99m BMS181321.
Topics: Animals; Hypoxia; Myocardial Ischemia; Myocardium; Nitroimidazoles; Organotechnetium Compounds; Rats; Technetium; Time Factors | 1996 |
Longevity of pimonidazole adducts in spontaneous canine tumors as an estimate of hypoxic cell lifetime.
Topics: Animals; Cell Survival; DNA Adducts; DNA, Neoplasm; Dog Diseases; Dogs; Hypoxia; Neoplasms; Nitroimidazoles | 1997 |
Contribution of hypoxia to the development of cardiomyopathy in hamsters.
Topics: Animals; Antipyrine; Autoradiography; Cardiomyopathy, Dilated; Cricetinae; Hypoxia; Iodine Radioisotopes; Mesocricetus; Myocardium; Nitroimidazoles; Organotechnetium Compounds | 1997 |
Cell cycle distribution of hypoxia and progression of hypoxic tumour cells in vivo.
Topics: Adenocarcinoma; Animals; Bromodeoxyuridine; Cell Cycle; Cell Division; DNA, Neoplasm; Flow Cytometry; Hypoxia; Mice; Neoplasms, Experimental; Nitroimidazoles; Sarcoma, Experimental; Theophylline | 1998 |
Carbogen breathing increases 5-fluorouracil uptake and cytotoxicity in hypoxic murine RIF-1 tumors: a magnetic resonance study in vivo.
Topics: Animals; Biological Transport; Carbon Dioxide; Fibrosarcoma; Fluorouracil; Hydrogen-Ion Concentration; Hypoxia; Mice; Mice, Inbred C3H; Nitroimidazoles; Nuclear Magnetic Resonance, Biomolecular; Oxygen; Sarcoma, Experimental | 1998 |
Reductive metabolism of the hypoxia marker pimonidazole is regulated by oxygen tension independent of the pyridine nucleotide redox state.
Topics: Animals; Biomarkers; Chromatography, High Pressure Liquid; Eating; Enzyme-Linked Immunosorbent Assay; Fasting; Glycolysis; Hypoxia; In Vitro Techniques; Kinetics; Liver; Microsomes, Liver; Nitroimidazoles; Oxidation-Reduction; Oxygen Consumption; Potassium Cyanide; Radiation-Sensitizing Agents; Rats | 1998 |
Cyclosporin A increases hypoxia and free radical production in rat kidneys: prevention by dietary glycine.
Topics: Animals; Creatinine; Cyclosporine; Food, Fortified; Free Radicals; Glomerular Filtration Rate; Glycine; Hypoxia; Kidney; Male; Models, Biological; Nitroimidazoles; Rats; Rats, Sprague-Dawley; Renal Circulation; Reperfusion Injury; Time Factors; Vasoconstriction | 1998 |
Evidence of hypoxic areas within the arterial wall in vivo.
Topics: Animals; Aorta, Thoracic; Arteriosclerosis; Fluorescent Antibody Technique, Direct; Hypoxia; Male; Nitroimidazoles; Rabbits; Theophylline | 1999 |
A bioluminescence method for the mapping of local ATP concentrations within the arterial wall, with potential to assess the in vivo situation.
Topics: Adenosine Triphosphate; Animals; Aorta; Arteriosclerosis; Culture Media; Dose-Response Relationship, Drug; Freezing; Glucose; Hypoxia; Image Processing, Computer-Assisted; Luminescent Measurements; Male; Nitroimidazoles; Oxygen; Rabbits; Swine; Theophylline; Time Factors | 1999 |
Graft survival is improved by hepatic denervation before organ harvesting.
Topics: Animals; Antihypertensive Agents; Denervation; Female; Graft Survival; Hepatic Artery; Hexamethonium; Hypoxia; Liver; Liver Transplantation; Microcirculation; Nitroimidazoles; Radiation-Sensitizing Agents; Rats; Rats, Inbred Lew; Reperfusion Injury; Tissue and Organ Procurement | 1999 |
Vascular architecture and microenvironmental parameters in human squamous cell carcinoma xenografts: effects of carbogen and nicotinamide.
Topics: Animals; Benzimidazoles; Blood Vessels; Carbon Dioxide; Carcinoma, Squamous Cell; Cell Division; Endothelium, Vascular; Humans; Hypoxia; Laryngeal Neoplasms; Mice; Mice, Nude; Neoplasm Transplantation; Niacinamide; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents; Theophylline; Transplantation, Heterologous; Tumor Cells, Cultured | 1999 |
Reperfusion injury in livers due to gentle in situ organ manipulation during harvest involves hypoxia and free radicals.
Topics: Animals; Cryopreservation; Enzyme-Linked Immunosorbent Assay; Female; Fluorescein-5-isothiocyanate; Fluorescent Dyes; Free Radicals; Hypoxia; Immunohistochemistry; In Vitro Techniques; Liver; Microcirculation; Nitroimidazoles; Organ Preservation; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Specimen Handling; Trypan Blue | 1999 |
Synthesis and characterization of lipophilic 1-[18F]fluoroalkyl-2-nitroimidazoles for imaging hypoxia.
Topics: Animals; Brain; Female; Fluorine Radioisotopes; Hypoxia; Imidazoles; Male; Mice; Mice, Inbred C3H; Neoplasms, Experimental; Nitro Compounds; Nitroimidazoles; Radionuclide Imaging; Rats; Rats, Wistar; Solubility; Tissue Distribution | 1999 |
Clinical pharmacokinetics of 123I-IAZA in healthy volunteers.
Topics: Adult; Female; Half-Life; Humans; Hypoxia; Iodine Radioisotopes; Male; Middle Aged; Models, Biological; Nitroimidazoles; Radionuclide Imaging; Radiopharmaceuticals; Tissue Distribution | 1999 |
Synthesis of new hypoxia markers EF1 and [18F]-EF1.
Topics: Biomarkers; Fluorine Radioisotopes; Hypoxia; Isotope Labeling; Nitroimidazoles; Radiopharmaceuticals; Tomography, Emission-Computed | 1999 |
Suramin treatment of human glioma xenografts; effects on tumor vasculature and oxygenation status.
Topics: Animals; Antineoplastic Agents; Blood Vessels; Brain Neoplasms; Glioma; Humans; Hypoxia; Mice; Mice, Nude; Neoplasm Transplantation; Nitroimidazoles; Oxygen Consumption; Staining and Labeling; Suramin; Transplantation, Heterologous | 1999 |
Hypoxia-dependent retinal toxicity of bioreductive anticancer prodrugs in mice.
Topics: Animals; Antineoplastic Agents; Dose-Response Relationship, Drug; Female; Hypoxia; Light; Mice; Mice, Inbred C57BL; Nitroimidazoles; Oxidation-Reduction; Prodrugs; Radiation-Sensitizing Agents; Retina; Tirapazamine; Triazines | 2000 |
Studies of methyl 2-nitroimidazole-1-acetohydroxamate (KIN-804) 2: effect on certain antioxidant enzyme systems in mice bearing Ehrlich ascites carcinoma.
Topics: Animals; Antioxidants; Carcinoma, Ehrlich Tumor; Catalase; Female; Hydroxamic Acids; Hypoxia; Lipid Peroxides; Liver; Lung; Mice; Nitroimidazoles; Radiation-Sensitizing Agents; Superoxide Dismutase | 2000 |
Vascular architecture and hypoxic profiles in human head and neck squamous cell carcinomas.
Topics: Aged; Biomarkers; Biopsy; Carcinoma, Squamous Cell; Female; Head and Neck Neoplasms; Humans; Hypopharyngeal Neoplasms; Hypoxia; Image Processing, Computer-Assisted; Immunohistochemistry; Laryngeal Neoplasms; Male; Microscopy, Fluorescence; Middle Aged; Nitroimidazoles; Oropharyngeal Neoplasms; Prognosis | 2000 |
Hypoxia in a human intracerebral glioma model.
Topics: Animals; Brain Neoplasms; Cell Division; Disease Models, Animal; Glioma; Hypoxia; Mice; Mice, Inbred BALB C; Microcirculation; Nitroimidazoles; Radiation-Sensitizing Agents | 2000 |
Nitroimidazoles and hypoxia imaging: synthesis of three technetium-99m complexes bearing a nitroimidazole group: biological results.
Topics: Animals; Heart; Hypoxia; In Vitro Techniques; Ligands; Molecular Structure; Nitroimidazoles; Perfusion; Radionuclide Imaging; Rats; Technetium; Technetium Compounds | 2001 |
Hypoxia-inducible expression of tumor-associated carbonic anhydrases.
Topics: Blotting, Western; Carbonic Anhydrases; Carcinoma; Carcinoma, Renal Cell; DNA-Binding Proteins; Endothelial Growth Factors; Genes, Reporter; Humans; Hypoxia; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Immunoblotting; Immunohistochemistry; In Situ Hybridization; Kidney Neoplasms; Lymphokines; Models, Genetic; Necrosis; Nitroimidazoles; Nuclear Proteins; Oxygen; Plasmids; Promoter Regions, Genetic; Radiation-Sensitizing Agents; RNA; RNA, Messenger; Skin Neoplasms; Transcription Factors; Tumor Cells, Cultured; Up-Regulation; Urinary Bladder Neoplasms; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2000 |
Determination of hypoxic region by hypoxia marker in developing mouse embryos in vivo: a possible signal for vessel development.
Topics: Animals; Antibodies, Monoclonal; Biomarkers; Blood Vessels; Brain; Bucladesine; Cell Differentiation; Cell Hypoxia; DNA-Binding Proteins; Embryonic and Fetal Development; Endothelial Growth Factors; Endothelium, Vascular; Gene Expression Regulation, Developmental; Hypoxia; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Lymphokines; Mice; Mice, Inbred BALB C; Nitroimidazoles; Nuclear Proteins; Platelet Endothelial Cell Adhesion Molecule-1; Stem Cells; Teratoma; Transcription Factors; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2001 |
New antimetastatic hypoxic cell radiosensitizers: design, synthesis, and biological activities of 2-nitroimidazole-acetamide, TX-1877, and its analogues.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Movement; Drug Design; Electrochemistry; Female; Hypoxia; Leukocytes, Mononuclear; Lung Neoplasms; Macrophages; Mice; Mice, Inbred C3H; Models, Molecular; Neoplasm Metastasis; Neoplasm Transplantation; Nitroimidazoles; Radiation-Sensitizing Agents; Structure-Activity Relationship; Tumor Cells, Cultured | 2001 |
Synthesis of [18F]-labeled EF3 [2-(2-nitroimidazol-1-yl)-N-(3,3,3-trifluoropropyl)-acetamide], a marker for PET detection of hypoxia.
Topics: Fluorine Radioisotopes; Humans; Hypoxia; Nitroimidazoles; Radiation Dosage; Radiopharmaceuticals; Structure-Activity Relationship; Tomography, Emission-Computed | 2001 |
Pharmacokinetics of [18F]FETNIM: a potential marker for PET.
Topics: Animals; Dogs; Female; Fluorine Radioisotopes; Head and Neck Neoplasms; Humans; Hypoxia; Mammary Neoplasms, Experimental; Nitroimidazoles; Rats; Rats, Sprague-Dawley; Tissue Distribution; Tomography, Emission-Computed | 2001 |
Dosimetry estimations for 123I-IAZA in healthy volunteers.
Topics: Female; Gamma Cameras; Humans; Hypoxia; Iodine Radioisotopes; Male; Nitroimidazoles; Radiometry; Radionuclide Imaging; Radiopharmaceuticals; Tissue Distribution | 2001 |
Imaging of blood flow and hypoxia in head and neck cancer: initial evaluation with [(15)O]H(2)O and [(18)F]fluoroerythronitroimidazole PET.
Topics: Aged; Female; Glucose; Glycolysis; Head and Neck Neoplasms; Humans; Hypoxia; Image Processing, Computer-Assisted; Isotope Labeling; Male; Middle Aged; Muscle, Skeletal; Nitroimidazoles; Oxygen Radioisotopes; Radiopharmaceuticals; Regional Blood Flow; Tomography, Emission-Computed | 2001 |
Measuring hypoxia in solid tumours--is there a gold standard?
Topics: Biopsy, Needle; Comet Assay; Humans; Hypoxia; Microelectrodes; Neoplasms; Nitroimidazoles; Palliative Care; Predictive Value of Tests; Radiation-Sensitizing Agents; Radiotherapy; Reference Values | 2001 |
Hypoxia in the thymus: role of oxygen tension in thymocyte survival.
Topics: Animals; Cell Survival; Cyclooxygenase 2; DNA Primers; Exons; Gene Expression Regulation; Genetic Markers; Heme Oxygenase (Decyclizing); Hypoxia; In Vitro Techniques; Introns; Isoenzymes; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Nitroimidazoles; Oxygen; Oxygen Consumption; Partial Pressure; Polymerase Chain Reaction; Prostaglandin-Endoperoxide Synthases; Radiation-Sensitizing Agents; RNA, Messenger; Thymus Gland; Transcription, Genetic | 2002 |
Quantitative analysis of varying profiles of hypoxia in relation to functional vessels in different human glioma xenograft lines.
Topics: Animals; Glioma; Humans; Hypoxia; Immunohistochemistry; Mice; Mice, Nude; Neoplasm Transplantation; Nitroimidazoles; Perfusion; Transplantation, Heterologous; Tumor Cells, Cultured | 2002 |
Oxygen-sensitive enzyme-prodrug gene therapy for the eradication of radiation-resistant solid tumours.
Topics: Animals; Combined Modality Therapy; Female; Fibrosarcoma; Genetic Therapy; Genetic Vectors; Humans; Hypoxia; Mice; Mice, Nude; Misonidazole; NADPH-Ferrihemoprotein Reductase; Neoplasm Transplantation; Nitroimidazoles; Prodrugs; Radiation Tolerance; Radiation-Sensitizing Agents; Transplantation, Heterologous; Tumor Cells, Cultured | 2002 |
Studies with bleomycin and misonidazole on aerated and hypoxic cells.
Topics: Bleomycin; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Hypoxia; Nitroimidazoles; Oxygen; Temperature | 1978 |
Hypoxic-cell sensitisers.
Topics: Cell Survival; Humans; Hypoxia; Misonidazole; Neoplasms; Nitroimidazoles; Oxygen Consumption; Radiation Tolerance | 1978 |
Hypoxic-cell sensitisers.
Topics: Dose-Response Relationship, Drug; Drug Evaluation; Humans; Hypoxia; Metronidazole; Misonidazole; Neoplasms; Nitroimidazoles | 1978 |
Influence of the hypoxic cell sensitizer misonidazole on the proliferation of well-oxygenated cells in vitro during prolonged exposure.
Topics: Animals; Cell Cycle; Cell Division; Cell Line; Hypoxia; Mice; Misonidazole; Mitosis; Nitroimidazoles; Osteosarcoma; Oxygen; Sarcoma, Experimental; Time Factors | 1979 |
A metabolite of the 2-nitroimidazole misonidazole with radiosensitizing properties.
Topics: Animals; Cell Line; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Hypoxia; Lung; Mice; Misonidazole; Nitroimidazoles; Oxidation-Reduction; Radiation Tolerance | 1978 |
[New aspects of radiotherapy. I. Significance of hypoxia in irradiation of solid tumors].
Topics: Dose-Response Relationship, Radiation; Hot Temperature; Humans; Hyperbaric Oxygenation; Hypoxia; Misonidazole; Neoplasms; Nitroimidazoles | 1979 |
Influence of misonidazole on the radiosensitivity of a human melanoma in nude mice: time-dependent increase in surviving fraction.
Topics: Animals; Cell Survival; Female; Humans; Hypoxia; In Vitro Techniques; Melanoma; Mice; Mice, Nude; Misonidazole; Neoplasms, Experimental; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents; Time Factors | 1979 |
Radiosensitization of mammalian cells by misonidazole and oxygen: DNA damage exposed by Micrococcus luteus enzymes.
Topics: Animals; Cell Survival; Cells, Cultured; Cricetinae; Cricetulus; DNA; Gamma Rays; Hypoxia; Micrococcus; Misonidazole; Nitroimidazoles; Oxygen; Radiation Tolerance; Radiation-Sensitizing Agents; Ultraviolet Rays | 1979 |
Hypoxic cell radiosensitizers--chemical aspects and in vitro models.
Topics: Animals; Cell Line; Chemical Phenomena; Chemistry; Cricetinae; Cricetulus; Hypoxia; Lung; Neoplasms, Experimental; Nitroimidazoles; Radiation-Sensitizing Agents; Structure-Activity Relationship | 1978 |
The use of hypoxic cell radiosensitizers with mixed X and alpha radiations.
Topics: Alpha Particles; Animals; Cell Line; Cell Survival; Cricetinae; Dose-Response Relationship, Radiation; Humans; Hypoxia; Nitroimidazoles; Plutonium; Radiation-Sensitizing Agents; X-Rays | 1977 |
Radiosensitizing and toxic effects of the 2-nitroimidazole Ro-07-0582 in different phases of the cell cycle of extremely hypoxic human cells in vitro.
Topics: Cell Cycle; Cell Survival; Cells, Cultured; Drug Evaluation, Preclinical; Female; Humans; Hypoxia; In Vitro Techniques; Nitroimidazoles; Radiation-Sensitizing Agents | 1978 |
Modification of radiation responses of murine tumors by misonidazole (Ro 07-0582), host immune capability, and Corynebacterium parvum.
Topics: Animals; Dose-Response Relationship, Radiation; Female; Hypoxia; Immunity; Immunotherapy; Mammary Neoplasms, Experimental; Mice; Mice, Inbred C3H; Nitroimidazoles; Oxygen; Propionibacterium acnes; Sarcoma, Experimental | 1978 |
Hypoxic cell sensitization by misonidazole in vivo and in vitro.
Topics: Cell Line; Dose-Response Relationship, Drug; Hypoxia; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents | 1978 |
Differences in the toxicity and metabolism of the 2-nitroimidazole misonidazole (Ro-07-0582) in HeLa and Chinese hamster ovary cells.
Topics: Cell Survival; Cells, Cultured; HeLa Cells; Hypoxia; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents | 1978 |
Studies on the toxicity and radiosensitizing ability of misonidazole under conditions of prolonged incubation.
Topics: Cell Survival; Cells, Cultured; Cobalt Radioisotopes; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Hypoxia; Misonidazole; Nitroimidazoles; Radiation Tolerance; Temperature; Time Factors | 1978 |
Radiosensitization of hypoxic tumor cells by simultaneous administration of hyperthermia and nitroimidazoles.
Topics: Animals; Carcinoma, Ehrlich Tumor; Cell Survival; Deoxyuridine; Female; Hyperthermia, Induced; Hypoxia; Leukemia L1210; Metronidazole; Mice; Mice, Inbred Strains; Neoplasms; Neoplasms, Experimental; Nitroimidazoles; Radiation Tolerance; Radiation-Sensitizing Agents; Sarcoma | 1977 |
Radiosensitizing and cytocidal effects on hypoxic cells of RO-07-0582, and repair of x-ray injury, in an experimental mouse tumour.
Topics: Animals; Carcinoma, Squamous Cell; Hypoxia; Male; Mice; Neoplasm Transplantation; Neoplasms, Experimental; Nitroimidazoles; Radiation-Sensitizing Agents; Skin Neoplasms; Transplantation, Homologous | 1977 |
Hypoxic cell radiosensitizers and local control by X-ray of a transplanted tumour in mice.
Topics: Animals; Hypoxia; Metronidazole; Mice; Neoplasm Metastasis; Neoplasm Transplantation; Neoplasms, Experimental; Nitrofurans; Nitroimidazoles; Radiation-Sensitizing Agents; Radiotherapy Dosage; Razoxane; Regeneration; Transplantation, Homologous | 1977 |
Cytotoxicity of Ro-07-0582; enhancement by hyperthermia and protection by cysteamine.
Topics: Cell Survival; Cells, Cultured; Chromosome Aberrations; Cysteamine; Gamma Rays; Hot Temperature; Hypoxia; Nitroimidazoles; Time Factors | 1977 |
Hypoxia-dependent reduction of 1-(2-nitro-1-imidazolyl)-3-methoxy-2-propanol by Chinese hamster ovary cells and KHT tumor cells in vitro and in vivo.
Topics: Animals; Cells, Cultured; Fibrosarcoma; Hypoxia; Nitrogen; Nitroimidazoles; Oxidation-Reduction; Radiation-Sensitizing Agents; Sarcoma, Experimental | 1976 |
Proceedings: The development of hypoxic cell sensitizers.
Topics: Acetophenones; Acriflavine; DNA, Bacterial; Electrons; Escherichia coli; Ethylmaleimide; Hypoxia; Nitroimidazoles; Oxygen Consumption; Radiation-Sensitizing Agents | 1975 |
Proceedings: Sensitization of hypoxic mammalian cells in vitro by some nitroimidazoles and nitropyrazoles.
Topics: Animals; Cells, Cultured; Hypoxia; In Vitro Techniques; Mammals; Nitro Compounds; Nitroimidazoles; Oxygen Consumption; Pyrazoles; Radiation-Sensitizing Agents | 1975 |
Proceedings: Radiosensitization of hypoxic cells in solid tumours in mice.
Topics: Animals; Fast Neutrons; Guinea Pigs; Humans; Hypoxia; Metronidazole; Mice; Nausea; Neoplasms, Experimental; Nitroimidazoles; Oxygen Consumption; Rabbits; Radiation-Sensitizing Agents; Rats | 1975 |
In vivo testing of hypoxic radiosensitizers using the KHT murine tumour assayed by the lung-colony technique.
Topics: Animals; Cell Division; Cell Survival; Dose-Response Relationship, Radiation; Hypoxia; Kinetics; Lethal Dose 50; Lung; Male; Metronidazole; Mice; Mice, Inbred C3H; Nitrobenzenes; Nitrofurans; Nitroimidazoles; Radiation Effects; Radiation-Sensitizing Agents; Sarcoma, Experimental | 1975 |
Proceedings: Identification of hypoxic mouse bone marrow CFU in vivo.
Topics: Animals; Bone Marrow; Bone Marrow Cells; Hypoxia; Mice; Nitroimidazoles; Pentobarbital; Radiation Effects | 1975 |
Clinical testing of the radiosensitiser Ro-07-0582. II. Radiosensitisation of normal and hypoxic skin.
Topics: Constriction; Drug Evaluation; Humans; Hypoxia; Metronidazole; Nitroimidazoles; Oxygen; Radiation Dosage; Radiation Effects; Radiation-Sensitizing Agents; Regression Analysis; Skin; Skin Pigmentation; Strontium Radioisotopes | 1976 |
Non-invasive assessment of human tumour hypoxia with 123I-iodoazomycin arabinoside: preliminary report of a clinical study.
Topics: Adult; Aged; Carcinoma, Small Cell; Female; Half-Life; Humans; Hypoxia; Iodine Radioisotopes; Lung Neoplasms; Male; Middle Aged; Neoplasms; Nitroimidazoles; Tomography, Emission-Computed | 1992 |
Effect of pH, oxygenation, and temperature on the cytotoxicity and radiosensitization by etanidazole.
Topics: Animals; Benzimidazoles; Cell Division; Cell Line; Cell Survival; Etanidazole; Fibrosarcoma; Flow Cytometry; Fluorescent Dyes; Hydrogen-Ion Concentration; Hyperthermia, Induced; Hypoxia; Nitroimidazoles; Radiation-Sensitizing Agents; Sarcoma, Experimental; Temperature | 1991 |
Fluorescent markers for hypoxic cells: a study of nitroaromatic compounds, with fluorescent heterocyclic side chains, that undergo bioreductive binding.
Topics: Animals; Chemical Phenomena; Chemistry; Cricetinae; Cricetulus; Flow Cytometry; Fluorescent Dyes; Hypoxia; Nitroimidazoles; Structure-Activity Relationship | 1991 |
KIH-802, an acetohydroxamic acid derivative of 2-nitroimidazole, as a new potent hypoxic cell radiosensitizer: radiosensitizing activity, acute toxicity, and pharmacokinetics.
Topics: Animals; Cell Division; Cell Survival; Dose-Response Relationship, Drug; Etanidazole; Female; Hydroxamic Acids; Hypoxia; Injections, Intravenous; Lethal Dose 50; Mice; Mice, Inbred BALB C; Mice, Inbred ICR; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents; Time Factors | 1990 |
Tumour radiosensitization by clofibrate and its analogs: possible mechanisms.
Topics: Animals; Bezafibrate; Clofibrate; Combined Modality Therapy; Etanidazole; Female; Hypoxia; Mice; Mice, Inbred C3H; Neoplasms, Experimental; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents; Regional Blood Flow | 1990 |
Radiotherapy using the hypoxic cell sensitizer Ro 03-8799 in malignant melanoma.
Topics: Adult; Aged; Aged, 80 and over; Female; Humans; Hypoxia; Lymph Nodes; Male; Melanoma; Middle Aged; Neoplasm Recurrence, Local; Nitroimidazoles; Palliative Care; Radiation Tolerance; Radiation-Sensitizing Agents; Skin Neoplasms | 1987 |
The in vitro interaction with DNA of several hypoxic radiosensitizers.
Topics: DNA; Dose-Response Relationship, Radiation; Glyoxylates; Hypoxia; Nitroimidazoles; Radiation-Sensitizing Agents; Spectrophotometry; Structure-Activity Relationship; X-Rays | 1989 |
Ocular penetration, toxicity, and radiosensitization effects of two hypoxic cell radiosensitizers on retinoblastoma.
Topics: Absorption; Animals; Cell Line; Etanidazole; Eye; Eye Neoplasms; Female; Hypoxia; Nitroimidazoles; Rabbits; Radiation-Sensitizing Agents; Retinoblastoma | 1986 |
Changes in ultrastructure and function of hypoxic V79 fibroblast cells after treatment with misonidazole.
Topics: Animals; Cells, Cultured; Cricetinae; Cricetulus; Electron Transport Complex IV; Fibroblasts; Hypoxia; Microscopy, Electron; Misonidazole; Mitochondrial Swelling; Nitroimidazoles; Oxygen; Time Factors | 1985 |
Synthesis and biodistribution of 18F-labeled fluoronitroimidazoles: potential in vivo markers of hypoxic tissue.
Topics: Animals; Fluorine; Hypoxia; Metronidazole; Misonidazole; Nitroimidazoles; Radioisotopes; Radionuclide Imaging; Rats; Rats, Inbred Strains; Tissue Distribution | 1986 |
Novel 1-haloalkyl-2-nitroimidazole bioreductive alkylating agents.
Topics: Alkylating Agents; Antineoplastic Agents; Cell Survival; Hypoxia; Kinetics; NADPH-Ferrihemoprotein Reductase; Nitroimidazoles; Oxidation-Reduction; Structure-Activity Relationship | 1988 |
Chloronitroimidazoles as radiosensitizers of hypoxic cells in vitro.
Topics: Aerobiosis; Animals; Cell Survival; Chlorine; Glutathione; Hypoxia; Metronidazole; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents; Rats; Structure-Activity Relationship | 1987 |
2-Chloro-4-nitroimidazole radiosensitizers of hypoxic tumor cells in vivo.
Topics: Algorithms; Animals; Hypoxia; Lethal Dose 50; Male; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Nitroimidazoles; Radiation-Sensitizing Agents; Rats; Rats, Inbred Strains; Rhabdomyosarcoma | 1987 |
Sensitization of cancer chemotherapeutic agents by nitroheterocyclics.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Cell Survival; Drug Synergism; Heterocyclic Compounds; Hydroxamic Acids; Hypoxia; Lomustine; Misonidazole; Neoplasms, Experimental; Nitroimidazoles; Radiation-Sensitizing Agents | 1986 |
Reduction of nitroimidazoles in vitro and DNA damage.
Topics: Anaerobiosis; Biological Transport; DNA; DNA, Bacterial; DNA, Viral; Free Radicals; Hypoxia; Mutation; Nitroimidazoles; Oxidation-Reduction | 1986 |
The effect of bioreduction on the oncogenicity of nitroimidazoles.
Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; Hypoxia; Mice; Mutagenicity Tests; Nitroimidazoles; Radiation-Sensitizing Agents | 1986 |
Potential radiosensitizing agents. 7. 4(5)-Iodo-5(4)-nitroimidazole derivatives.
Topics: Animals; Cell Survival; Cells, Cultured; Cricetinae; Cricetulus; Hypoxia; Nitroimidazoles; Radiation-Sensitizing Agents; Structure-Activity Relationship | 1985 |
Effect of hypoxic cell radiosensitizers on glutathione level and related enzyme activities in isolated rat hepatocytes.
Topics: Animals; Dose-Response Relationship, Drug; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Glutathione Transferase; Hydrogen Peroxide; Hypoxia; Imidazoles; Liver; Male; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents; Rats; Rats, Inbred Strains; Time Factors | 1985 |
Radiosensitization of C3H mouse mammary tumours by a 2-nitroimidazole drug.
Topics: 1-Propanol; Animals; Female; Hypoxia; Mammary Neoplasms, Experimental; Mice; Mice, Inbred C3H; Neoplasm Transplantation; Nitroimidazoles; Oxygen Consumption; Preventive Medicine; Propanols; Radiation-Sensitizing Agents; Radiotherapy Dosage; Transplantation, Homologous | 1974 |