azomycin has been researched along with EHS Tumor in 75 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 59 (78.67) | 18.7374 |
| 1990's | 14 (18.67) | 18.2507 |
| 2000's | 1 (1.33) | 29.6817 |
| 2010's | 1 (1.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Denekamp, J; Minchinton, AI; Stratford, MR; Williams, MV | 1 |
| Chu, T; Mei, L; Wang, Y | 1 |
| Fitzmaurice, RJ; Lunt, SJ; Stratford, IJ; Telfer, BA; Williams, KJ | 1 |
| Mulcahy, RT; Siemann, DW; Sutherland, RM | 2 |
| Twentyman, PR | 1 |
| McNally, NJ | 2 |
| Denekamp, J; Rojas, A; Stewart, FA | 1 |
| Denekamp, J; Rojas, A | 1 |
| Brown, DM; Brown, JM; Lee, WW; Yu, NY | 1 |
| Siemann, DW | 3 |
| Brown, JM; Evans, JW; Horsman, MR | 1 |
| Hill, SA; Keng, PC; Siemann, DW | 1 |
| Bauer, KD; Hill, SA; Keng, PC; Siemann, DW | 1 |
| Hill, SA; Siemann, DW | 1 |
| Maddison, K; Siemann, DW; Wolf, K | 1 |
| Grdina, DJ; Milas, L; Thames, HD | 1 |
| Lee, FY; Workman, P | 2 |
| Meyn, RE; Murray, D | 1 |
| Morrissey, S; Siemann, DW; Wolf, K | 1 |
| Baer, K; Chapman, JD; Lee, J | 1 |
| Twentyman, PR; Workman, P | 2 |
| de Ronde, J; Hinchliffe, M; McNally, NJ | 1 |
| Mulcahy, RT; Siemann, DW | 1 |
| Crabtree, KE; Curtis, SB; Flynn, MJ; Howard, J; Lyman, JT; Parr, SS; Tenforde, SD; Tenforde, TS | 1 |
| Twentyman, P; Workman, P | 1 |
| Brown, JM; Hirst, DG | 1 |
| Chin, JB; Rauth, AM | 1 |
| Kochanski, K; Siemann, DW | 1 |
| De Ronde, J; Martin, WM; McNally, NJ | 1 |
| Brown, JM; Hirst, DG; Law, MP | 1 |
| Grimmett, EV; Hofer, KG; Lehr, JE; MacKinnon, AR; Schubert, AL | 1 |
| Denekamp, J; Hirst, DG; Stewart, FA; Terry, NH | 1 |
| Grdina, DJ; Jovonovich, JA; Sigdestad, CP | 1 |
| Tannock, IF | 2 |
| Hodgkiss, RJ; Webster, L; Wilson, GD | 3 |
| Adams, GE; Butler, SA; Cole, SM; Sansom, JM; Stratford, IJ; Szabo, C; Thiemermann, C; Wood, PJ | 1 |
| Adams, GE; Bradley, JK; Bremner, JC; Naylor, MA; Sansom, JM; Stratford, IJ | 1 |
| Arnold, S; Chaplin, DJ; Collingridge, D; Hill, SA; Horsman, MR; Overgaard, J; Radacic, M; Wood, PJ | 1 |
| Scobie, M; Threadgill, MD; Wood, PJ | 1 |
| Aboagye, EO; Cannell, MB; Griffiths, JR; Judson, IR; Leach, MO; McSheehy, PM; Ojugo, AS; Robinson, SP | 1 |
| Feinedegen, LE; Gartzen, J; Geweher, K; Mühlensiepen, H; Porschen, W; Weber, HJ | 1 |
| Chin, J; Marchow, L; Paciga, J; Rauth, AM | 1 |
| Smink, T; van Putten, LM | 1 |
| Bush, RS; Hill, RP | 1 |
| Reddy, EK | 1 |
| Deys, BF; Stap, J | 1 |
| Milas, L; Stone, HB | 1 |
| George, KC; Hirst, DG; McNally, NJ | 1 |
| Gulyas, S; Mohindra, JK; Varghese, AJ | 1 |
| Kaufman, K; Rauth, AM | 1 |
| Adams, GE; Cole, S; Elliott, W; Fielden, EM; Leopold, W; Sebolt-Leopold, J; Stratford, IJ; Suto, M | 1 |
| Binger, M; Workman, P | 1 |
| Herman, TS; Holden, SA; Teicher, BA | 1 |
| Hodgkiss, RJ; Jones, G; Long, A; Parrick, J; Smith, KA; Stratford, MR; Wilson, GD | 1 |
| Adams, GE; Bowler, J; Cole, S; Lorimore, SA; Nolan, J; Stratford, IJ; Wright, EG | 1 |
| Workman, P | 2 |
| Herman, TS; Holden, SA; Jones, SM; Teicher, BA | 1 |
| Cornago, P; Lopez Zumel, MC; Pintado, M; Santos, L | 1 |
| Goodgame, DM; Joy, AM; Stratford, IJ | 1 |
| Griffiths, JR; Maxwell, RJ; Workman, P | 1 |
| Bleehen, NM; Walton, MI; Workman, P | 2 |
| Hofer, KG; Hofer, MG; Lakkis, M | 1 |
| Hill, SA; Keng, PC; Maddison, K; Siemann, DW; Wolf, K | 1 |
1 review(s) available for azomycin and EHS Tumor
| Article | Year |
|---|---|
Radiation sensitizers.
Topics: Animals; Antineoplastic Agents; Bromodeoxycytidine; Bromodeoxyuridine; Carcinoma; Deoxyuridine; Dogs; Dose-Response Relationship, Radiation; Floxuridine; Humans; Hypoxia; Idoxuridine; Lung Neoplasms; Methotrexate; Metronidazole; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Nitroimidazoles; Radiation-Sensitizing Agents; Research; Sarcoma, Experimental; Skin | 1976 |
74 other study(ies) available for azomycin and EHS Tumor
| Article | Year |
|---|---|
In vivo assessment of basic 2-nitroimidazole radiosensitizers.
Topics: Animals; Dose-Response Relationship, Drug; Female; Fibrosarcoma; Mice; Mice, Inbred Strains; Nitroimidazoles; Radiation-Sensitizing Agents; Sarcoma, Experimental | 1982 |
⁹⁹mTc/Re complexes bearing bisnitroimidazole or mononitroimidazole as potential bioreductive markers for tumor: synthesis, physicochemical characterization and biological evaluation.
Topics: Animals; Biomarkers, Tumor; Chemistry, Physical; Electrochemical Techniques; Mice; Mice, Inbred Strains; Molecular Structure; Nitroimidazoles; Organometallic Compounds; Oxidation-Reduction; Rats; Rhenium; Sarcoma, Experimental; Technetium; Tissue Distribution | 2012 |
Tirapazamine administered as a neoadjuvant to radiotherapy reduces metastatic dissemination.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Combined Modality Therapy; Female; Hypoxia; Mice; Mice, Inbred C3H; Neoadjuvant Therapy; Neoplasm Metastasis; Neoplasm Transplantation; Neovascularization, Pathologic; Nitroimidazoles; Radiation-Sensitizing Agents; Sarcoma, Experimental; Tirapazamine; Treatment Outcome; Triazines | 2005 |
Nitrosourea-misonidazole combination chemotherapy: effect on KHT sarcomas, marrow stem cells and gut.
Topics: Animals; Antineoplastic Agents; Carmustine; Cell Survival; Cells, Cultured; Colony-Forming Units Assay; Drug Therapy, Combination; Female; Gastrointestinal Diseases; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Sarcoma, Experimental; Streptozocin | 1982 |
Modification of tumour and host response to cyclophosphamide by misonidazole and by WR 2721.
Topics: Amifostine; Animals; Body Weight; Cyclophosphamide; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Leukocyte Count; Male; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Organothiophosphorus Compounds; Sarcoma, Experimental | 1981 |
The effect of misonidazole combined with WR2721 on tumour response and leucopenia due to cyclophosphamide or melphalan.
Topics: Amifostine; Animals; Cell Survival; Cyclophosphamide; Drug Therapy, Combination; Leukopenia; Melphalan; Mice; Mice, Inbred Strains; Misonidazole; Nitroimidazoles; Organothiophosphorus Compounds; Sarcoma, Experimental | 1982 |
Interaction of misonidazole and WR-2721--II. Modification of tumour radiosensitization.
Topics: Amifostine; Animals; Cell Division; Cell Survival; Dose-Response Relationship, Drug; Drug Interactions; Fibrosarcoma; Mice; Misonidazole; Neoplasms, Experimental; Nitroimidazoles; Organothiophosphorus Compounds; Radiation Tolerance; Sarcoma, Experimental | 1983 |
Time dependence of interaction of misonidazole and WR-2721.
Topics: Amifostine; Animals; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Interactions; Fibrosarcoma; Mice; Misonidazole; Neoplasm Transplantation; Nitroimidazoles; Organothiophosphorus Compounds; Sarcoma, Experimental; Time Factors | 1983 |
SR-2508: a 2-nitroimidazole amide which should be superior to misonidazole as a radiosensitizer for clinical use.
Topics: Animals; Carcinoma; Cell Line; Central Nervous System; Cricetinae; Dogs; Etanidazole; Female; In Vitro Techniques; Lipid Metabolism; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Misonidazole; Neoplasms, Experimental; Nitroimidazoles; Radiation-Sensitizing Agents; Sarcoma, Experimental; X-Rays | 1981 |
Response of murine tumours to combinations of CCNU with misonidazole and other radiation sensitizers.
Topics: Animals; Dose-Response Relationship, Drug; Drug Therapy, Combination; Etanidazole; Female; Leukocyte Count; Lomustine; Metronidazole; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Nitrosourea Compounds; Radiation-Sensitizing Agents; Sarcoma, Experimental | 1982 |
Enhancement of melphalan-induced tumour cell killing by misonidazole: an interaction of competing mechanisms.
Topics: Animals; Body Temperature; Cell Survival; Drug Synergism; Female; Kinetics; Melphalan; Metabolic Clearance Rate; Mice; Mice, Inbred C3H; Misonidazole; Neoplasm Transplantation; Nitroimidazoles; Sarcoma, Experimental; Time Factors | 1984 |
Survival in subpopulations of cells derived from solid KHT sarcomas by centrifugal elutriation following treatment with CCNU and MISO.
Topics: Animals; Cell Cycle; Cell Separation; Cell Survival; Drug Synergism; Drug Therapy, Combination; Flow Cytometry; Lomustine; Mice; Mice, Inbred C3H; Misonidazole; Neoplasm Transplantation; Nitroimidazoles; Radiation-Sensitizing Agents; Sarcoma, Experimental | 1984 |
The effect in the KHT sarcoma of CCNU and MISO on cell cycle progression evaluated by flow-cytometry.
Topics: Animals; Cell Cycle; DNA, Neoplasm; Drug Synergism; Drug Therapy, Combination; Flow Cytometry; Lomustine; Mice; Mice, Inbred C3H; Misonidazole; Neoplasm Transplantation; Nitroimidazoles; Radiation-Sensitizing Agents; RNA, Neoplasm; Sarcoma, Experimental | 1984 |
Enhanced tumor responses through therapies combining CCNU, MISO and radiation.
Topics: Animals; Combined Modality Therapy; Drug Synergism; Drug Therapy, Combination; Female; Lomustine; Mice; Mice, Inbred C3H; Misonidazole; Neoplasm Transplantation; Nitroimidazoles; Radiation-Sensitizing Agents; Sarcoma, Experimental; Time Factors | 1984 |
Potentiation of melphalan activity in the KHT sarcoma by the radiosensitizer RSU 1069.
Topics: Animals; Aziridines; Azirines; Cell Survival; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Female; Melphalan; Mice; Misonidazole; Neoplasm Transplantation; Nitroimidazoles; Radiation-Sensitizing Agents; Sarcoma, Experimental; Time Factors | 1984 |
Tumor sensitizing effect by misonidazole in a clinically relevant radiation dose range.
Topics: Animals; Cell Survival; Cells, Cultured; Dose-Response Relationship, Radiation; Female; Fibrosarcoma; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Radiation Tolerance; Sarcoma, Experimental; Tumor Stem Cell Assay | 1984 |
Misonidazole and CCNU: further evidence for a pharmacokinetic mechanism of chemosensitization and therapeutic gain.
Topics: Animals; Bone Marrow; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Intestine, Small; Kinetics; Lomustine; Male; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Sarcoma, Experimental | 1984 |
Enhancement of the DNA cross-linking activity of melphalan by misonidazole in vivo.
Topics: Animals; Cross-Linking Reagents; DNA; DNA Repair; DNA, Neoplasm; Fibrosarcoma; Glutathione; Jejunum; Maleates; Melphalan; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Sarcoma, Experimental; Spleen | 1983 |
In vivo potentiation of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea by the radiation sensitizer benznidazole.
Topics: Animals; Dose-Response Relationship, Drug; Drug Synergism; Lomustine; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Nitrosourea Compounds; Radiation-Sensitizing Agents; Sarcoma, Experimental; Time Factors | 1983 |
Characteristics of the metabolism-induced binding of misonidazole to hypoxic mammalian cells.
Topics: Anaerobiosis; Animals; Binding, Competitive; Cell Line; Cricetinae; Cricetulus; Fibrosarcoma; Kidney; Kinetics; Mice; Misonidazole; Nitroimidazoles; Sarcoma, Experimental; Temperature | 1983 |
Chemosensitization by lipophilic nitroimidazoles.
Topics: Animals; Cyclophosphamide; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Leukocyte Count; Lomustine; Male; Melphalan; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Sarcoma, Experimental; Time Factors | 1983 |
Enhancement of the action of alkylating agents by single high, or chronic low doses of misonidazole.
Topics: Animals; Cell Survival; Cyclophosphamide; Drug Administration Schedule; Drug Synergism; Drug Therapy, Combination; Leukopenia; Melphalan; Mice; Mice, Inbred Strains; Misonidazole; Nitroimidazoles; Sarcoma, Experimental; Time Factors | 1983 |
In vivo chemosensitization by misonidazole in sensitive and resistant tumor lines.
Topics: Animals; Carmustine; Cell Line; Drug Resistance; Drug Synergism; Humans; Leukemia L1210; Lomustine; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Nitrosourea Compounds; Sarcoma, Experimental | 1983 |
Misonidazole enhancement of radiation-induced growth delay in rat rhabdomyosarcoma tumours exposed to accelerated carbon and neon ions.
Topics: Animals; Carbon; Cell Survival; Dose-Response Relationship, Radiation; Energy Transfer; Misonidazole; Neon; Nitroimidazoles; Particle Accelerators; Radiation-Sensitizing Agents; Rats; Rhabdomyosarcoma; Sarcoma, Experimental | 1981 |
Effect of misonidazole or metronidazole pretreatment on the response of the RIF-1 mouse sarcoma to melphalan, cyclophosphamide, chlorambucil and CCNU.
Topics: Animals; Antineoplastic Agents; Cell Survival; Chlorambucil; Cyclophosphamide; Drug Synergism; Drug Therapy, Combination; Female; Lethal Dose 50; Leukocyte Count; Lomustine; Male; Melphalan; Metronidazole; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Sarcoma, Experimental | 1982 |
Effect of clinical levels of misonidazole on the response of tumour and normal tissues in the mouse to alkylating agents.
Topics: Animals; Bone Marrow; Cyclophosphamide; Dose-Response Relationship, Drug; Drug Synergism; Female; Lethal Dose 50; Leukocyte Count; Melphalan; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Sarcoma, Experimental | 1982 |
Structure/activity relationships for the enhancement by electron-affinic drugs of the anti-tumour effect of CCNU.
Topics: Animals; Cell Division; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Lomustine; Mice; Mice, Inbred C3H; Nitroimidazoles; Nitrosourea Compounds; Oxidation-Reduction; Sarcoma, Experimental; Solubility; Structure-Activity Relationship | 1982 |
In vivo combination of misonidazole and the chemotherapeutic agent CCNU.
Topics: Animals; Cell Survival; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Lomustine; Mice; Misonidazole; Nitroimidazoles; Nitrosourea Compounds; Sarcoma, Experimental; Time Factors | 1981 |
The metabolism and pharmacokinetics of the hypoxic cell radiosensitizer and cytotoxic agent, misonidazole, in C3H mice.
Topics: Animals; Autoradiography; Chromatography, Paper; Kinetics; Male; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Oxygen; Polarography; Sarcoma, Experimental; Time Factors; Tissue Distribution | 1981 |
Combinations of radiation and misonidazole in a murine lung tumor model.
Topics: Animals; Cell Survival; Dose-Response Relationship, Radiation; Female; Lung; Lung Neoplasms; Mice; Misonidazole; Neoplasm Transplantation; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents; Radiotherapy; Sarcoma, Experimental; Time Factors | 1981 |
Enhancement of the effect of cytotoxic drugs by radiosensitizers.
Topics: Animals; Cell Survival; Cyclophosphamide; Dose-Response Relationship, Drug; Drug Synergism; Fibrosarcoma; In Vitro Techniques; Melphalan; Mice; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents; Sarcoma, Experimental; Urination | 1981 |
Enhancing effect of misonidazole on the response of the RIF-1 tumour to cyclophosphamide.
Topics: Animals; Cell Line; Cell Survival; Cyclophosphamide; Dose-Response Relationship, Drug; Drug Synergism; Hematopoietic Stem Cells; Leukocytes; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Sarcoma, Experimental | 1981 |
Radiosensitization of tumors and normal tissues by combined treatment with misonidazole and heat.
Topics: Animals; Bone Marrow; Cell Survival; Cells, Cultured; Dose-Response Relationship, Radiation; Female; Hot Temperature; Intestinal Mucosa; Mice; Mice, Inbred C3H; Mice, Inbred DBA; Mice, Inbred ICR; Misonidazole; Nitroimidazoles; Oxygen; Radiation Tolerance; Sarcoma, Experimental; Skin | 1981 |
Is tumour radiosensitization by misonidazole a general phenomenon?
Topics: Animals; Carcinoma; Cell Line; Dose-Response Relationship, Radiation; Male; Mice; Misonidazole; Neoplasms, Experimental; Nitroimidazoles; Oxygen; Radiation Tolerance; Sarcoma, Experimental; Time Factors | 1980 |
The effect of misonidazole in situ on the radiation response of selected tumor subpopoulations.
Topics: Animals; Cell Survival; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Female; Fibrosarcoma; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents; Sarcoma, Experimental | 1980 |
In vivo interaction of anti-cancer drugs with misonidazole or metronidazole: methotrexate, 5-fluorouracil and adriamycin.
Topics: Animals; Body Weight; Doxorubicin; Drug Therapy, Combination; Fibrosarcoma; Fluorouracil; Leukocyte Count; Male; Mammary Neoplasms, Experimental; Methotrexate; Metronidazole; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Sarcoma, Experimental | 1980 |
In vivo interaction of anti-cancer drugs with misonidazole or metronidazole: cyclophosphamide and BCNU.
Topics: Animals; Body Weight; Carmustine; Cyclophosphamide; Drug Therapy, Combination; Fibrosarcoma; Leukocyte Count; Male; Mammary Neoplasms, Experimental; Metronidazole; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Sarcoma, Experimental | 1980 |
In vivo response of KHT sarcomas to combination chemotherapy with radiosensitizers and BCNU.
Topics: Animals; Carmustine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Sarcoma, Experimental; Time Factors | 1981 |
Development of bioreductive markers for tumour hypoxia.
Topics: Animals; Antibodies; Antibodies, Monoclonal; Caffeine; Carcinoma; Cell Division; Cell Hypoxia; Cell Line; DNA, Neoplasm; Mice; Mice, Inbred CBA; Nitroimidazoles; Radiation-Sensitizing Agents; Sarcoma, Experimental; Theophylline; Tumor Cells, Cultured | 1995 |
Chemosensitization of CCNU in KHT murine tumor cells in vivo and in vitro by the agent RB 6145 and its isomer PD 144872.
Topics: Animals; Cell Survival; Dose-Response Relationship, Drug; Drug Synergism; Lomustine; Mice; Nitroimidazoles; Prodrugs; Sarcoma, Experimental; Stereoisomerism; Tumor Cells, Cultured | 1995 |
Induction of hypoxia in experimental murine tumors by the nitric oxide synthase inhibitor, NG-nitro-L-arginine.
Topics: Animals; Arginine; Carcinoma; Cell Hypoxia; Cell Survival; Drug Screening Assays, Antitumor; Drug Synergism; Energy Metabolism; Female; Magnetic Resonance Spectroscopy; Male; Mice; Mice, Inbred C3H; Nitroarginine; Nitroimidazoles; Phosphates; Prodrugs; Sarcoma, Experimental | 1994 |
Comparing the anti-tumor effect of several bioreductive drugs when used in combination with photodynamic therapy (PDT).
Topics: Animals; Antineoplastic Agents; Mice; Mice, Inbred C3H; Misonidazole; Mitomycin; Nitroimidazoles; Photochemotherapy; Sarcoma, Experimental | 1994 |
Effect of nitro-L-arginine on blood flow, oxygenation and the activity of hypoxic cell cytotoxins in murine tumours.
Topics: Animals; Antineoplastic Agents; Cell Hypoxia; Female; Hyperthermia, Induced; Mammary Neoplasms, Experimental; Mice; Mice, Inbred C3H; Mice, Inbred CBA; Nitroarginine; Nitroimidazoles; Regional Blood Flow; Sarcoma, Experimental | 1996 |
Uptake and retention of nitroimidazole-carboranes designed for boron neutron capture therapy in experimental murine tumours: detection by 11B magnetic resonance spectroscopy.
Topics: Animals; Boron Compounds; Boron Neutron Capture Therapy; Carcinoma, Squamous Cell; Magnetic Resonance Spectroscopy; Mice; Molecular Structure; Nitroimidazoles; Sarcoma, Experimental | 1996 |
Cell cycle distribution of hypoxia and progression of hypoxic tumour cells in vivo.
Topics: Adenocarcinoma; Animals; Bromodeoxyuridine; Cell Cycle; Cell Division; DNA, Neoplasm; Flow Cytometry; Hypoxia; Mice; Neoplasms, Experimental; Nitroimidazoles; Sarcoma, Experimental; Theophylline | 1998 |
Measurement of hypoxia in vivo using a 2-nitroimidazole (NITP).
Topics: Adenocarcinoma; Animals; Cell Hypoxia; Female; Flow Cytometry; Fluorescent Antibody Technique, Indirect; Mammary Neoplasms, Experimental; Mice; Nitroimidazoles; Oxygen; Respiration; Sarcoma, Experimental; Theophylline | 1997 |
Carbogen breathing increases 5-fluorouracil uptake and cytotoxicity in hypoxic murine RIF-1 tumors: a magnetic resonance study in vivo.
Topics: Animals; Biological Transport; Carbon Dioxide; Fibrosarcoma; Fluorouracil; Hydrogen-Ion Concentration; Hypoxia; Mice; Mice, Inbred C3H; Nitroimidazoles; Nuclear Magnetic Resonance, Biomolecular; Oxygen; Sarcoma, Experimental | 1998 |
In vivo assay of the radiation sensitivity of hypoxic tumour cells; influence of gamma-rays cyclotron neutrons, misonidazole, hyperthermia and mixed modalities.
Topics: Animals; Cell Survival; Fast Neutrons; Gamma Rays; Hot Temperature; Mice; Nitroimidazoles; Oxygen; Radiation Tolerance; Sarcoma, Experimental; Time Factors | 1978 |
Testing of hypoxic cell radiosensitizers in vivo.
Topics: Animals; Cell Survival; Metronidazole; Mice; Mice, Inbred C3H; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents; Sarcoma, Experimental | 1978 |
Misonidazole with small dose fractions in an experimental osteosarcoma.
Topics: Animals; Mice; Nitroimidazoles; Osteosarcoma; Radiation-Sensitizing Agents; Radiotherapy Dosage; Sarcoma, Experimental | 1978 |
The effect of misonidazole in combination with radiation dose fractionation.
Topics: Animals; Cell Survival; Male; Mice; Mice, Inbred C3H; Nitroimidazoles; Radiation-Sensitizing Agents; Radiotherapy Dosage; Sarcoma, Experimental | 1978 |
A comparison of the effects of tumour growth delay of fractionated and single dose irradiation when administered with misonidazole (Ro-07-0582).
Topics: Animals; Fibrosarcoma; Male; Nitroimidazoles; Radiation-Sensitizing Agents; Radiotherapy Dosage; Rats; Sarcoma, Experimental; Time Factors | 1978 |
Influence of the hypoxic cell sensitizer misonidazole on the proliferation of well-oxygenated cells in vitro during prolonged exposure.
Topics: Animals; Cell Cycle; Cell Division; Cell Line; Hypoxia; Mice; Misonidazole; Mitosis; Nitroimidazoles; Osteosarcoma; Oxygen; Sarcoma, Experimental; Time Factors | 1979 |
Modification of radiation responses of murine tumors by misonidazole (Ro 07-0582), host immune capability, and Corynebacterium parvum.
Topics: Animals; Dose-Response Relationship, Radiation; Female; Hypoxia; Immunity; Immunotherapy; Mammary Neoplasms, Experimental; Mice; Mice, Inbred C3H; Nitroimidazoles; Oxygen; Propionibacterium acnes; Sarcoma, Experimental | 1978 |
Effect of hyperthermia on cytotoxicity of the radiosensitizer Ro-07-0582 in a solid mouse tumour.
Topics: Animals; Cell Survival; Fibrosarcoma; Hot Temperature; Mice; Nitroimidazoles; Radiation-Sensitizing Agents; Sarcoma, Experimental; Time Factors | 1977 |
Hypoxia-dependent reduction of 1-(2-nitro-1-imidazolyl)-3-methoxy-2-propanol by Chinese hamster ovary cells and KHT tumor cells in vitro and in vivo.
Topics: Animals; Cells, Cultured; Fibrosarcoma; Hypoxia; Nitrogen; Nitroimidazoles; Oxidation-Reduction; Radiation-Sensitizing Agents; Sarcoma, Experimental | 1976 |
In vivo testing of hypoxic radiosensitizers using the KHT murine tumour assayed by the lung-colony technique.
Topics: Animals; Cell Division; Cell Survival; Dose-Response Relationship, Radiation; Hypoxia; Kinetics; Lethal Dose 50; Lung; Male; Metronidazole; Mice; Mice, Inbred C3H; Nitrobenzenes; Nitrofurans; Nitroimidazoles; Radiation Effects; Radiation-Sensitizing Agents; Sarcoma, Experimental | 1975 |
The effect of an hypoxic cell sensitizer on tumour growth delay and cell survival. Implications for cell survival in situ and in vitro.
Topics: Animals; Cell Survival; Male; Mice; Neoplasm Metastasis; Nitroimidazoles; Radiation-Sensitizing Agents; Sarcoma, Experimental | 1975 |
Dual function nitroimidazoles less toxic than RSU 1069: selection of candidate drugs for clinical trial (RB 6145 and/or PD 130908.
Topics: Animals; Cell Hypoxia; Combined Modality Therapy; Drug Evaluation; Mice; Mice, Inbred C3H; Misonidazole; Neoplasm Transplantation; Nitroimidazoles; Radiation-Sensitizing Agents; Sarcoma, Experimental | 1992 |
Pharmacokinetic contribution to the improved therapeutic selectivity of a novel bromoethylamino prodrug (RB 6145) of the mixed-function hypoxic cell sensitizer/cytotoxin alpha-(1-aziridinomethyl)-2-nitro-1H-imidazole-1-ethanol (RSU 1069).
Topics: Animals; Antineoplastic Agents; Chromatography, High Pressure Liquid; Female; Half-Life; Mice; Mice, Inbred C3H; Misonidazole; Neoplasm Transplantation; Nitroimidazoles; Prodrugs; Sarcoma, Experimental | 1991 |
Effect of pH, oxygenation, and temperature on the cytotoxicity and radiosensitization by etanidazole.
Topics: Animals; Benzimidazoles; Cell Division; Cell Line; Cell Survival; Etanidazole; Fibrosarcoma; Flow Cytometry; Fluorescent Dyes; Hydrogen-Ion Concentration; Hyperthermia, Induced; Hypoxia; Nitroimidazoles; Radiation-Sensitizing Agents; Sarcoma, Experimental; Temperature | 1991 |
Flow cytometric evaluation of hypoxic cells in solid experimental tumours using fluorescence immunodetection.
Topics: Animals; Cell Hypoxia; Cricetinae; Cricetulus; Flow Cytometry; Fluorescent Antibody Technique; Neoplasms, Experimental; Nitroimidazoles; Sarcoma, Experimental; Theophylline | 1991 |
Oral (po) dosing with RSU 1069 or RB 6145 maintains their potency as hypoxic cell radiosensitizers and cytotoxins but reduces systemic toxicity compared with parenteral (ip) administration in mice.
Topics: Administration, Oral; Animals; Combined Modality Therapy; Injections, Intraperitoneal; Mice; Mice, Inbred C3H; Misonidazole; Neoplasm Transplantation; Nitroimidazoles; Radiation-Sensitizing Agents; Sarcoma, Experimental | 1991 |
Accelerated elimination of pimonidazole following microsomal enzyme induction in mice: a possible approach to reduced neurotoxicity of the pimonidazole-etanidazole combination.
Topics: Animals; Brain; Drug Combinations; Enzyme Induction; Etanidazole; Mice; Mice, Inbred C3H; Microsomes, Liver; Neoplasm Transplantation; Nitroimidazoles; Phenobarbital; Radiation-Sensitizing Agents; Sarcoma, Experimental | 1989 |
Addition of misonidazole, etanidazole, or hyperthermia to treatment with fluosol-DA/carbogen/radiation.
Topics: Animals; Carbon Dioxide; Combined Modality Therapy; Drug Combinations; Etanidazole; Fibrosarcoma; Fluorocarbons; Hydroxyethyl Starch Derivatives; Hyperthermia, Induced; Male; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents; Sarcoma, Experimental | 1989 |
Inhibition of the semiconservative DNA synthesis and potentiation of the unscheduled DNA synthesis by 5-nitroimidazole derivatives with an imidazolium or pyridinium ring.
Topics: Animals; Cell Line; Cell Transformation, Viral; Cricetinae; DNA Replication; Hydroxyurea; Kinetics; Mesocricetus; Molecular Structure; Nitroimidazoles; Pyridinium Compounds; Sarcoma, Experimental; Simian virus 40; Structure-Activity Relationship; Time Factors; X-Rays | 1989 |
High efficiency of ferricenium salts as radiosensitizers of V79 cells in vitro and the KHT tumor in vivo.
Topics: Animals; Cell Line; Cell Survival; Combined Modality Therapy; Female; Ferrous Compounds; In Vitro Techniques; Mice; Mice, Inbred C3H; Nitroimidazoles; Radiation-Sensitizing Agents; Sarcoma, Experimental | 1989 |
Demonstration of tumor-selective retention of fluorinated nitroimidazole probes by 19F magnetic resonance spectroscopy in vivo.
Topics: Animals; Magnetic Resonance Spectroscopy; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Misonidazole; Neoplasm Transplantation; Neoplasms, Experimental; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents; Sarcoma, Experimental | 1989 |
Effects of localised tumour hyperthermia on pimonidazole (Ro 03-8799) pharmacokinetics in mice.
Topics: Animals; Body Temperature; Hyperthermia, Induced; Lethal Dose 50; Male; Mice; Mice, Inbred C3H; Nitroimidazoles; Radiation-Sensitizing Agents; Sarcoma, Experimental | 1989 |
Cytocidal effects of misonidazole, Ro 03-8799, and RSU-1164 on euoxic and hypoxic BP-8 murine sarcoma cells at normal and elevated temperatures.
Topics: Animals; Combined Modality Therapy; Female; Hyperthermia, Induced; Iodine Radioisotopes; Mice; Misonidazole; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents; Sarcoma, Experimental; Tumor Cells, Cultured | 1989 |
The effects of whole body hyperthermia on the pharmacokinetics and toxicity of the basic 2-nitroimidazole radiosensitizer Ro 03-8799 in mice.
Topics: Animals; Body Temperature; Brain; Chromatography, High Pressure Liquid; Female; Glomerular Filtration Rate; Hyperthermia, Induced; Kinetics; Male; Mice; Mice, Inbred C3H; Nitroimidazoles; Radiation-Sensitizing Agents; Sarcoma, Experimental | 1987 |
Altered pharmacokinetics in the mechanism of chemosensitization: effects of nitroimidazoles and other chemical modifiers on the pharmacokinetics, antitumour activity and acute toxicity of selected nitrogen mustards.
Topics: Animals; Blood Proteins; Chromatography, High Pressure Liquid; Drug Interactions; Hydrolysis; Kinetics; Male; Mice; Mice, Inbred C3H; Misonidazole; Nitrogen Mustard Compounds; Nitroimidazoles; Protein Binding; Sarcoma, Experimental | 1986 |
Chemosensitization of lomustine by misonidazole, benznidazole, and RSU 1069.
Topics: Animals; Lomustine; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Sarcoma, Experimental | 1986 |
In vivo interaction between radiation and 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea in the absence or presence of misonidazole in mice.
Topics: Animals; Combined Modality Therapy; Female; Lomustine; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Sarcoma, Experimental; Tumor Stem Cell Assay | 1985 |