aspirin and Psoriasis studies

Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.

Psoriasis: A common genetically determined, chronic, inflammatory skin disease characterized by rounded erythematous, dry, scaling patches. The lesions have a predilection for nails, scalp, genitalia, extensor surfaces, and the lumbosacral region. Accelerated epidermopoiesis is considered to be the fundamental pathologic feature in psoriasis.

Research Excerpts

Excerpt	Relevance	Reference
"Hydroxyurea has been rarely implicated as a cause of drug fever."	7.66	Fever caused by hydroxyurea. ( Bauernfeind, RA; Bauman, JL; Hartsough, N; Hasegawa, GR; Roden, R; Shulruff, S, 1981)
"The aim of the reported series of experiments was to examine the possible role played by arachidonic acid (Aa) derivatives in monocyte aggregation in psoriasis."	3.67	Arachidonic acid and LTB4 enhance aggregation of psoriatic peripheral blood mononuclear leukocytes in vitro. ( Altomare, GF; Pigatto, PD; Polenghi, MM; Tadini, GL; Villa, S, 1987)
"Hydroxyurea has been rarely implicated as a cause of drug fever."	3.66	Fever caused by hydroxyurea. ( Bauernfeind, RA; Bauman, JL; Hartsough, N; Hasegawa, GR; Roden, R; Shulruff, S, 1981)
"Psoriasis is highly prevalent and is associated with skin-associated complaints as well as arthritis, depression and a lower quality of life."	2.45	Psoriasis: an opportunity to identify cardiovascular risk. ( Federman, DG; Gunderson, CG; Kirsner, RS; Prodanovich, S; Shelling, M, 2009)
"Associations between Kawasaki disease and psoriasis, between Kawasaki disease and varicella and between varicella and psoriasis have all been reported in the literature."	1.48	Plaque psoriasis following Kawasaki disease and varicella. ( Boiy, T; Maes, M; Sillen, H; Wojciechowski, M, 2018)
"A 3 year-old boy was seen for a febrile exanthema suggestive of Kawasaki disease (bilateral conjunctivitis, red and fissured lips, palmoplantar erythema, scarlet fever-like rash and perineal desquamation) associated with pustular lesions."	1.32	[Kawasaki's disease with eruptive pustular and guttate psoriasis]. ( Barat, P; Boralevi, F; Léauté-Labrèze, C; Lepreux, S; Stockman, AL; Taïeb, A, 2003)

Research

Studies (36)

Authors

Clinical Trials (1)

Trial Overview

Trial Outcomes

Change in Levels of Circulating Thromboxane B2

Timeframe	Studies, this research(%)	All Research%
pre-1990	24 (66.67)	18.7374
1990's	4 (11.11)	18.2507
2000's	3 (8.33)	29.6817
2010's	4 (11.11)	24.3611
2020's	1 (2.78)	2.80

Authors	Studies
Garshick, MS	1
Tawil, M	1
Barrett, TJ	1
Salud-Gnilo, CM	1
Eppler, M	1
Lee, A	1
Scher, JU	1
Neimann, AL	1
Jelic, S	1
Mehta, NN	1
Fisher, EA	1
Krueger, JG	1
Berger, JS	1
Sillen, H	1
Maes, M	1
Boiy, T	1
Wojciechowski, M	1
Wu, S	1
Han, J	1
Qureshi, AA	1
Rowe, E	1
Federman, DG	1
Shelling, M	1
Prodanovich, S	1
Gunderson, CG	1
Kirsner, RS	1
Savoia, F	1
Gaddoni, G	1
Casadio, C	1
Patrizi, A	1
Spadola, G	1
Bassi, P	1
Albertini, F	1
Ballardini, G	1
Briganti, E	1
Casolari, S	1
De Donà, D	1
Menni, B	1
Zanotti, M	1
De Angelis, P	1
Boralevi, F	1
Barat, P	1
Lepreux, S	1
Stockman, AL	1
Taïeb, A	1
Léauté-Labrèze, C	1
SHELLEY, WB	2
Tsai, HJ	1
Wu, WM	1
Chang, YC	1
Wang, CM	1
Hong, HS	1
Sills, EM	1
Wüthrich, B	1
Misch, K	1
Davies, M	1
Greaves, M	1
Coutts, A	1
Bauman, JL	1
Shulruff, S	1
Hasegawa, GR	1
Roden, R	1
Hartsough, N	1
Bauernfeind, RA	1
Ballmer-Weber, BK	1
Widmer, M	1
Burg, G	1
Zivony, D	1
Nocton, J	1
Wortmann, D	1
Esterly, N	1
Burgers, SA	1
van Vloten, WA	1
O'Duffy, JD	1
Vila, L	1
Cullaré, C	1
Solá, J	1
Puig, L	1
de Castellarnau, C	1
de Moragas, JM	1
Pigatto, PD	1
Polenghi, MM	1
Altomare, GF	1
Tadini, GL	1
Villa, S	1
Françon, MF	1
Cosh, JA	1
Steinberg, AD	1
Soren, A	1
Diem, E	1
Fritsch, P	1
Lacourciére, Y	1
Baker, H	2
Moore-Robinson, M	1
Dick, WC	1
Collins, KE	1
Buchanan, WW	1
Moleres Ferrandis, R	1
Muñoz Guillén, L	1
Solente, G	1
Najbrt, V	1
Brázdová, O	1
Rothermich, NO	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Subclinical Cardiovascular Disease in Psoriatic Disease[NCT03228017]	Phase 4	63 participants (Actual)	Interventional	2017-08-01	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Platelet activation is measured by levels of circulating thromboxane b2, which will be measured after 2- weeks of aspirin 81mg therapy (NCT03228017)
Timeframe: Baseline (pre-Aspirin), 2 weeks (post-Aspirin)

Fold Change Change in Composite Endothelial Inflammation

Intervention	ng/ml (Median)
Psoriatic Disease Patients	1
Healthy Control	4.05

Endothelial inflammation will be monitored after 2 weeks of aspirin 81mg therapy (NCT03228017)
Timeframe: Baseline (pre-Aspirin), 2 weeks (post-Aspirin)

Fold Change in Composite Endothelial Inflammation

Intervention	Fold Change (Mean)
Psoriatic Disease Patients	-0.28
Healthy Control	-0.04

Endothelial inflammation will be monitored after 2- weeks of 40mg of atorvastatin therapy. (NCT03228017)
Timeframe: Baseline (pre-Atorvastatin), 2 weeks (post-Atorvastatin)

Mean Fold Change in Brachial Vein Endothelial Inflammatory Transcript

Intervention	Fold Change (Mean)
Psoriatic Disease Patients	-0.1
Healthy Control	0.1

Endothelial sampling coupled to real-time PCR analysis will be used to monitor brachial vein endothelial inflammation (NCT03228017)
Timeframe: Baseline, 5 Months

Article	Year
Psoriasis: an opportunity to identify cardiovascular risk. The British journal of dermatology, 2009, Volume: 160, Issue:1 Topics: Aspirin; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Dyslipidemias; F	2009
[Allergic and pseudoallergic skin reactions to drugs and food additives]. Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 1983, May-17, Volume: 72, Issue:20 Topics: Aspirin; Chronic Disease; Dermatitis, Contact; Drug Hypersensitivity; Drug Tolerance; Female; Food A	1983
An approach to the use of immunosuppressive drugs in nonmalignant diseases. The Journal of allergy and clinical immunology, 1973, Volume: 52, Issue:4 Topics: Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Chlorambucil; Cyclophosphamide; G	1973
Cutaneous responses to aspirin and its derivatives. The British journal of dermatology, 1970, Volume: 82, Issue:3 Topics: Aspirin; Erythema; Erythema Multiforme; Humans; Psoriasis; Purpura; Salicylates; Skin Diseases; Urti	1970

Article	Year
Plaque psoriasis following Kawasaki disease and varicella. BMJ case reports, 2018, Aug-03, Volume: 2018 Topics: Aspirin; Chickenpox; Humans; Immunoglobulins, Intravenous; Infant; Male; Mometasone Furoate; Mucocut	2018
Use of aspirin, non-steroidal anti-inflammatory drugs, and acetaminophen (paracetamol), and risk of psoriasis and psoriatic arthritis: a cohort study. Acta dermato-venereologica, 2015, Volume: 95, Issue:2 Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Arthritis,	2015
[Psoriasis therapy. Dose regulation or aspirin to control flush]. MMW Fortschritte der Medizin, 2014, Nov-06, Volume: 156, Issue:19 Topics: Aspirin; Flushing; Fumarates; Germany; Guideline Adherence; Humans; Psoriasis	2014
A case of aseptic pleuropericarditis in a patient with chronic plaque psoriasis under methotrexate therapy. Dermatology online journal, 2010, Feb-15, Volume: 16, Issue:2 Topics: Anti-Inflammatory Agents; Aspirin; Chronic Disease; Colchicine; Dermatologic Agents; Drug Therapy, C	2010
[Kawasaki's disease with eruptive pustular and guttate psoriasis]. Annales de dermatologie et de venereologie, 2003, Volume: 130, Issue:5 Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Buttocks; Child, Preschool; Exanthema; Humans; Imm	2003
BIRCH POLLEN AND ASPIRIN PSORIASIS. A STUDY IN SALICYLATE HYPERSENSITIVITY. JAMA, 1964, Sep-28, Volume: 189 Topics: Aspirin; Betula; Chemical Phenomena; Chemistry; Child; Drug Hypersensitivity; Drug Tolerance; Pollen	1964
Annular pustules in Kawasaki disease: a further case indicating the association with psoriasis? Cutis, 2003, Volume: 72, Issue:5 Topics: Aspirin; Child, Preschool; Diagnosis, Differential; Female; Humans; Immunoglobulin G; Mucocutaneous	2003
[Psoriasis inveterata treated by aspirin and cortisone]. Archives belges de dermatologie et de syphiligraphie, 1951, Volume: 7, Issue:3 Topics: Aspirin; Cortisone; Exanthema; Psoriasis	1951
[Psoriasis treated by aspirin]. Archives belges de dermatologie et de syphiligraphie, 1951, Volume: 7, Issue:3 Topics: Aspirin; Humans; Psoriasis	1951
Generalized pustular psoriasis induced by potassium iodide. A postulated role for dihydrofolic reductase. JAMA, 1967, Sep-25, Volume: 201, Issue:13 Topics: Adolescent; Adrenal Cortex Hormones; Aspirin; Female; Folic Acid; Humans; Iodides; Iron; Male; Middl	1967
Psoriatic arthritis in childhood. The Johns Hopkins medical journal, 1980, Volume: 146, Issue:2 Topics: Adolescent; Adult; Arthritis, Juvenile; Aspirin; Child; Child, Preschool; Female; Humans; Infant; Ma	1980
Pharmacological studies of anthralin erythema. The British journal of dermatology, 1981, Volume: 105 Suppl 20 Topics: Anthracenes; Anthralin; Aspirin; Betamethasone Valerate; Chlorpheniramine; Erythema; Female; Humans;	1981
Fever caused by hydroxyurea. Archives of internal medicine, 1981, Volume: 141, Issue:2 Topics: Aspirin; Female; Fever; Humans; Hydroxyurea; Middle Aged; Psoriasis; Recurrence	1981
[Acetylsalicylic acid-induced generalized pustulosis]. Schweizerische medizinische Wochenschrift, 1993, Mar-27, Volume: 123, Issue:12 Topics: Acute Disease; Aspirin; Diagnosis, Differential; Drug Eruptions; Female; Humans; Middle Aged; Psoria	1993
Juvenile Reiter's syndrome: a report of four cases. Journal of the American Academy of Dermatology, 1998, Volume: 38, Issue:1 Topics: Adolescent; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Arthritis,	1998
[Findings in children with psoriasis]. Nederlands tijdschrift voor geneeskunde, 1999, Jan-16, Volume: 143, Issue:3 Topics: Adolescent; Adrenal Cortex Hormones; Anthralin; Anti-Inflammatory Agents; Aspirin; Calcitriol; Child	1999
Psoriatic arthritis. Postgraduate medicine, 1977, Volume: 61, Issue:1 Topics: Adolescent; Adult; Arthritis; Aspirin; Female; Humans; Male; Methotrexate; Middle Aged; Psoriasis; R	1977
Cyclooxygenase activity is increased in platelets from psoriatic patients. The Journal of investigative dermatology, 1991, Volume: 97, Issue:5 Topics: Adult; Arachidonic Acid; Aspirin; Blood Platelets; Carbon Radioisotopes; Collagen; Humans; Kinetics;	1991
Arachidonic acid and LTB4 enhance aggregation of psoriatic peripheral blood mononuclear leukocytes in vitro. Archives of dermatological research, 1987, Volume: 279, Issue:5 Topics: Adult; Aged; Arachidonic Acid; Arachidonic Acids; Aspirin; Cell Aggregation; Female; Humans; In Vitr	1987
[The therapeutic prognosis in chronic evolutive polyarthritis (C.E.P.)]. Lyon medical, 1967, Jan-08, Volume: 217, Issue:2 Topics: Adrenocorticotropic Hormone; Adult; Anti-Inflammatory Agents; Antimalarials; Arthritis, Juvenile; Ar	1967
Anti-inflammatory drugs in rheumatic diseases. The Practitioner, 1974, Volume: 213, Issue:1276 SPEC Topics: Adrenocorticotropic Hormone; Anti-Inflammatory Agents; Antimalarials; Arthritis, Rheumatoid; Aspirin	1974
Psoriatic arthritis. JAMA, 1973, Apr-30, Volume: 224, Issue:5 Suppl Topics: Arthritis; Aspirin; Glucocorticoids; Gold; Humans; Methotrexate; Psoriasis	1973
Transport of salicylates from blood to joint fluid. Archives of internal medicine, 1973, Volume: 132, Issue:5 Topics: Administration, Oral; Adult; Arthritis; Arthritis, Rheumatoid; Aspirin; Bursitis; Humans; Middle Age	1973
[Salicylate poisoning by percutaneous resorption]. Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 1973, Volume: 24, Issue:12 Topics: Administration, Topical; Aspirin; Deafness; Epistaxis; Female; Hallucinations; Headache; Humans; Poi	1973
[Scintigraphy with marked polyphosphates in the diagnosis of inflammatory joint diseases]. L'union medicale du Canada, 1974, Volume: 103, Issue:4 Topics: Arthritis; Arthritis, Rheumatoid; Aspirin; Automation; Female; Humans; Male; Phosphates; Psoriasis;	1974
Clinical studies on inflammation in small diarthrodial joints. Technetium ( 99m Tc) percentage uptakes in various arthritides and studies on the effect of aspirin in rheumatoid arthritis. Clinical science, 1972, Volume: 42, Issue:3 Topics: Administration, Oral; Adult; Aged; Arthritis; Arthritis, Rheumatoid; Aspirin; Female; Finger Joint;	1972
[Treatment of psoriatic arthropathy]. Revista espanola de reumatismo y enfermedades osteoarticulares, 1971, Volume: 14, Issue:4 Topics: Administration, Oral; Adult; Aged; Allopurinol; Antimalarials; Arthritis; Aspirin; Female; Humans; M	1971
[An unknowed keratolytic agent: urea]. Bulletin de la Societe francaise de dermatologie et de syphiligraphie, 1971, Volume: 78, Issue:4 Topics: Aspirin; Dermatologic Agents; Drug Combinations; Humans; Ichthyosis; Lanolin; Psoriasis; Urea	1971
Intermittent high dose oral methotrexate therapy in psoriasis. The British journal of dermatology, 1970, Volume: 82, Issue:1 Topics: Adult; Aged; Aspirin; Ataxia; Colitis; Female; Hematologic Diseases; Humans; Male; Methotrexate; Mid	1970
[Mercury levels in the urine during treatment of infantile psoriasis with mercuric sulfide ointment]. Ceskoslovenska pediatrie, 1968, Volume: 23, Issue:8 Topics: Adolescent; Aspirin; Child; Child, Preschool; Female; Humans; Liver Function Tests; Male; Mercury; O	1968
An extended study of indomethacin. II. Clinical therapy. JAMA, 1966, Mar-28, Volume: 195, Issue:13 Topics: Adolescent; Adult; Arthritis; Arthritis, Rheumatoid; Aspirin; Child; Female; Gout; Humans; Indometha	1966

aspirin and Psoriasis