arginine and Ache

arginine has been researched along with Ache in 126 studies

Research

Studies (126)

TimeframeStudies, this research(%)All Research%
pre-19902 (1.59)18.7374
1990's31 (24.60)18.2507
2000's50 (39.68)29.6817
2010's33 (26.19)24.3611
2020's10 (7.94)2.80

Authors

AuthorsStudies
Abbaszadeh, F; Fakhri, S; Farzaei, MH; Mohammadi, S; Mohammadi-Farani, A1
Bakshi, N; Dampier, C; Figueroa, J; Khemani, K; Kumari, P; Lane, PA; Leake, D; Morris, CR; Reyes, LZ1
Gladwin, MT; Hopper, RK1
Cunha, MP; Dafre, AL; de Almeida, GRL; Selhorst, I; Szczepanik, JC1
Arslan, G; Demirkazik, A; Ozdemir, E; Pelit, A; Taskiran, AS1
Brown, LAS; Dampier, CD; Figueroa, J; Harris, F; Kumari, P; Lane, PA; Manoranjithan, S; Mendis, RD; Morris, CR; Reynolds, M; Shiva, S; Watt, A1
Edwards, M; Matheson, JR; Newcombe, RG; Seong, J; Weddell, L; West, NX1
Ahmadi-Zeidabadi, M; Jeddi, S; Kohlmeier, KA; Mohammadi, F; Shabani, M1
Abbaszadeh, F; Ahmadpour, Y; Fakhri, S; Ghanbarveisi, F; Gravandi, MM; Iranpanah, A; Kooshki, L; Moradi, SZ; Rezaei, H1
Gladwin, MT; Kim-Shapiro, DB1
Ahmadimoghaddam, D; Izadidastenaei, Z; Mohammadi, S; Salehi, I; Zarei, M1
Fouladzadeh, A; Ghafghazi, S; Moghimi, M; Nemati, Y; Parvardeh, S; Safaripour, S1
Liu, WZ; Wang, CL; Wang, XF; Yang, DJ; Yuan, BY; Zhang, YZ1
Hamada, Y; Narita, M; Neyama, H; Tsukahara, R; Tsukamoto, K; Ueda, H1
Andrade Próspero, DF; de Castro Almeida, FR; de Sousa, DP; Lopes, EM; Piauilino, CA; Reis Filho, AC1
Claydon, NC; Davies, M; Macdonald, EL; Seong, J; West, NX1
Milovanović, A; Prostran, M; Srebro, DP; Vučetić, Č; Vučković, S; Vujović, KS1
Plotnikov, DV; Sever'yanova, LА1
Adesanya, ET; Adeyemi, OO; Alohan, DO; Ishola, IO1
Hara, T; Ide, S; Kaneda, K; Koseki, K; Maruyama, C; Minami, M; Naka, T; Ohno, A; Tamano, R; Yoshioka, M1
Santana, DG; Santos, CA; Santos, DS; Thomazzi, SM1
Ansari, M; Gildengorin, G; Kuypers, FA; Lavrisha, L; Morris, CR; Neumayr, L; Stewart, M; Sweeters, N; Vichinsky, EP1
Cortes, S; Costa, A; Duarte, I; Galdino, G; Romero, T; Santos, R; Silva, G1
Prostran, MS; Savic Vujovic, KR; Srebro, DP; Vucković, SM1
Chen, JQ; Dai, TJ; Tang, QF; Zeng, YM1
Acuña, MA; Benke, D; Ralvenius, WT; Rudolph, U; Zeilhofer, HU1
Dehpour, AR; Ejtemaei-Mehr, S; Hassanipour, M; Khan, MI; Moghaddaskho, F; Momeny, M; Mumtaz, F; Ostadhadi, S1
Kuphal, KE; Pedrazzini, T; Solway, B; Taylor, BK1
Jesse, CR; Nogueira, CW; Rocha, JB; Savegnago, L1
Dyuizen, IV; Lamash, NE1
Hernández, L; Páez, X; Quiñones, B; Silva, E1
Calixto, JB; Chaves, J; Ferreira, VM; Guginski, G; Luiz, AP; Martins, DF; Massaro, M; Mattos, RW; Santos, AR; Silva, MD; Silveira, D1
Miyazaki, R; Yamada, T; Yamamoto, T1
Chereshnev, I; Criesta, M; Kolesnikov, YA; Pan, YX; Pasternak, GW1
Amaral, JF; Araújo, FL; Barbosa-Filho, JM; de Sousa, FC; Gutierrez, SJ; Leite, CP; Melo, CT; Moura, BA; Rocha, NF; Vasconcelos, SM; Viana, GS1
Clemente-Napimoga, JT; Ferreira, VH; Napimoga, MH; Parada, CA; Pellegrini-da-Silva, A; Tambeli, CH1
Hashemi, M; Karami, M; Sahebgharani, M; Zarrindast, MR1
Li, K; Qi, WX1
Guo, C; Li, Q; Ni, JM; Wang, CL; Wang, R; Wang, YQ; Zhou, Y1
Akhtar, MN; Akira, A; Israf, DA; Khalid, MH; Khalivulla, SI; Lajis, N; Mohamad, AS; Ong, HM; Perimal, EK; Sulaiman, MR; Zareen, S1
Bernardo, A; Capsoni, S; Cattaneo, A; Ceci, M; Covaceuszach, S; Marinelli, S; Minghetti, L; Pavone, F; Ugolini, G1
Ellrich, J; Isaak, A1
Bose, SC; Corder, G; Donahue, RR; Solway, B; Taylor, BK1
Akhtar, MN; Akira, A; Israf, DA; Khalid, MH; Lajis, N; Mohamad, AS; Perimal, EK; Sulaiman, MR1
Baydemir, C; Dogan, AE; Erol, K; Kilic, FS1
Côrtes, SF; Duarte, ID; Galdino, GS; Perez, AC; Resende, LC; Romero, TR; Silva, GC1
Bode-Böger, SM; Jäger, K; Kielstein, JT; Martens-Lobenhoffer, J; Nave, H; Perthel, R; Rong, S; Suntharalingam, M1
Hosseini, M; Karami, R; Khatami, L; Khodabandehloo, F; Taiarani, Z1
Bustos, PS; Cabrera, JL; Chiabrando, GA; Ortega, MG; Pierosan, L; Santos, AR; Saragusti, AC1
Alves, DP; da Motta, PG; Duarte, ID; Klein, A; Romero, TR1
Cavalcante Melo, FH; Citó, Mdo C; de Sousa, DP; de Sousa, FC; de Vasconcelos, SM; Fernandes, ML; Rios, ER; Rocha, NF1
Franke, S; Hein, G1
Amarante, LH; Duarte, ID1
Chelly, JE; Doursout, MF; Liang, Y1
He, ZJ; Micci, MA; Pasricha, PJ; Shenoy, M; Toma, H; Winston, JH; Xiao, SY; Zou, L1
Sadan, G; Tasatargil, A1
Fang, L; Lin, Q; Ren, Y; Wang, J; Willis, WD; Zou, X1
Déciga-Campos, M; López-Muñoz, FJ1
Dmitrieva, N; Hernández, L; Pérez, J; Rodríguez-Malaver, AJ1
Bocheva, A1
Déciga-Campos, M; Díaz-Reval, MI; González-Trujano, ME; López-Muñoz, FJ; Ventura-Martínez, R1
Angers, P; Dalbó, S; Jürgensen, S; Ribeiro-do-Valle, RM; Santos, AR1
Aronov, S; Ben-Abraham, R; Givati-Divshi, D; Katz, Y2
Kamei, J; Saitoh, A; Tamura, N1
Calixto, JB; Kassuya, CA; Luiz, AP; Meotti, FC; Pizzolatti, MG; Santos, AR1
Bunnett, NW; Divino, LA; Grady, EF; Grahn, SW; Hoge, SG; Kim, E; Kirkwood, KS; Wick, EC1
Grady, EF; Kirkwood, KS; Pikios, S; Wick, EC1
Facundo, VA; Marques, MC; Pietrovski, EF; Rios, K; Rosa, KA; Santos, AR1
Miguel, TT; Nunes-de-Souza, RL1
Abdel-Hady, RH; Abdel-Rahman, S; Abdel-Zaher, AO; Aly, SA; Hamdy, MM1
Abdullah, FC; Balakhrisnan, G; Jais, AM; Jayaraman, KV; Somchit, MN; Sulaiman, MR; Zakaria, ZA1
Brito, GA; Cunha, FQ; Ferreira, SH; Lotufo, CM; Ribeiro, RA; Sachs, D; Vale, ML1
Belmonte, C; Carreño, C; Fernández-Carvajal, A; Ferrer-Montiel, A; Ferroni, S; García-Martínez, C; Gomis, A; Valenzuela, B; Van Den Nest, W1
Bramwell, S; Corradini, L; Cox, PJ; Dolphin, AC; England, S; Field, MJ; Hendrich, J; Kinloch, RA; Melrose, H; Offord, J; Stott, E; Su, TZ; Webb, T; Williams, D; Winks, J1
Hernández, L; Silva, E1
Joharchi, K; Jorjani, M1
Abacioglu, N; Altug, S; Tunctan, B; Uludag, O; Zengil, H1
Galloway, GP; Kielstein, A; Mendelson, JE; Tsikas, D1
Azevedo, AO; Braga, FC; Campos, JJ; Duarte, ID; Galdino, GS; Perez, AC1
Kienle, G1
Hao, JX; Wiesenfeld-Hallin, Z; Xu, XJ1
de Vente, J; Garthwaite, J; Gittins, SR; Morris, R; Southam, E1
Kawabata, A; Manabe, S; Manabe, Y; Takagi, H1
Coderre, TJ; Yashpal, K1
Rice, AS1
Hayaishi, O; Hyodo, M; Ito, S; Minami, T; Nishihara, I; Sakamoto, K1
Babbedge, RC; Gaffen, ZA; Hart, SL; Moore, PK; Wallace, P1
Mizuguchi, T; Shimoyama, N; Yamamoto, T1
Björkman, R1
Feria, M; Niedbala, B; Sánchez, A1
Gebhart, GF; Kolhekar, R; Meller, ST1
Asano, H; Mizuguchi, T; Shimoyama, N; Yamamoto, T1
Malmberg, AB; Yaksh, TL1
Calixto, JB; Filho, VC; Santos, AR; Yunes, RA1
Hayaishi, O; Ito, S; Minami, T; Mori, H; Okuda-Ashitaka, E; Onaka, M1
Ferreira, SH; Lorenzetti, BB1
Bhargava, HN; Bian, JT1
Basak, AK; Das, M; Koley, B; Koley, J; Sinha, S1
Kamenskiĭ, AA; Mikoian, VD; Savel'eva, KV; Sebentsova, EA; Vanin, AF1
Danilova, EI; Grafova, VN; Kukushkin, ML; Zinkevich, VA1
Goto, K; Ishige, A; Kamei, J; Komatsu, Y; Suzuki, Y1
Ahn, C; Alvarez, M; Buchman, AL; Dennis, K; O'Brien, W; Ou, CN; Rognerud, C1
Budziñski, M; Dorociak, A; Gumulka, W; Misterek, K1
Lawand, NB; McNearney, T; Westlund, KN1
Abacioğlu, N; Cakici, I; Demir, S; Kanzik, I; Tunçtan, B1
Alba, G; Contreras, Q; Guerrero, F; Hernandez, L; Silva, E1
Aracil, A; Belmonte, C; Ferrer-Montiel, AV; Gallar, J; González-Ros, JM; Merino, JM; Pérez-Payá, E; Planells-Cases, R1
Francés, B; Latapie, JP; Zajac, JM1
Bartholomew, J; Berkowitz, SD; Fareed, J; Hursting, MJ; Jang, IK; Kelton, JG; Lerner, RG; Lewis, BE; Matthai, WH; Moran, J; Rifkin, SD; Rustagi, PK; Sham, R; Walenga, JM; Wallis, DE; Zeigler, ZR1
Ichikawa, A; Ito, S; Kobayashi, T; Minami, T; Nakano, H; Narumiya, S; Sugimoto, Y; Ushikubi, F1
Fujii, K; Kanno, Y; Konishi, K; Ohgou, N1
Jain, NK; Kulkarni, SK; Patil, CS; Singh, A1
Cai, Y; Kovacs, KJ; Larson, AA1
Freund, N; Gonzalez, LE; Hernandez, L; Quiñones, B; Silva, E1
Chapman, V; Dickenson, A; Haley, J; Schachter, M1
Dykstra, C; Gebhart, GF; Meller, ST1
Pieper, GM; Tseng, LF; Xu, JY1
Babbedge, RC; Gaffen, Z; Hart, SL; Moore, PK; Morgan, CV; Wallace, P1
Gebhart, GF; Maves, TJ; Meller, ST; Pechman, PS1
Ceppi Monti, N; Gazzaniga, A; Gianesello, V; Lodola, E; Stroppolo, F1
Harima, A; Shimizu, H; Takagi, H1
Babbedge, RC; Hart, SL; Moore, PK; Oluyomi, AO; Wallace, P1
Takagi, H1
Cook, A; Goldberg, A; Herrick, AL; McColl, KE; Moore, MR1
Sun, J; Yan, J; Zeng, Z1

Reviews

5 review(s) available for arginine and Ache

ArticleYear
The expanding impact of methylglyoxal on behavior-related disorders.
    Progress in neuro-psychopharmacology & biological psychiatry, 2023, 01-10, Volume: 120

    Topics: Arginine; Cysteine; Dopamine; Glycation End Products, Advanced; Humans; Lysine; Magnesium Oxide; Mental Disorders; Nucleotides; Pain; Pyruvaldehyde

2023
Asymmetric dimethylarginine (ADMA)--a modulator of nociception in opiate tolerance and addiction?
    Nitric oxide : biology and chemistry, 2007, Volume: 17, Issue:2

    Topics: Analgesics, Opioid; Arginine; Drug Tolerance; Humans; Nitric Oxide Synthase Type I; Opioid-Related Disorders; Pain

2007
Central antinociceptive effects of non-steroidal anti-inflammatory drugs and paracetamol. Experimental studies in the rat.
    Acta anaesthesiologica Scandinavica. Supplementum, 1995, Volume: 103

    Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arginine; Behavior, Animal; Brain; Chemoreceptor Cells; Diclofenac; Ibuprofen; Male; Mechanoreceptors; Naloxone; Nociceptors; Pain; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-1; Receptors, Serotonin; Spinal Cord; Thermoreceptors

1995
Electrophysiological approaches to the study of bradykinin and nitric oxide in inflammatory pain.
    Agents and actions. Supplements, 1992, Volume: 38 ( Pt 2)

    Topics: Animals; Arginine; Bradykinin; Formaldehyde; Inflammation; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroarginine; Pain; Rats; Receptors, Bradykinin; Receptors, Neurotransmitter; Spinal Cord

1992
[Physiological and pharmacological actions of a neuroactive dipeptide, kyotorphin, and its precursor, L-arginine, and clinical application].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1990, Volume: 96, Issue:3

    Topics: Analgesics; Animals; Arginine; Brain; Chronic Disease; Endorphins; Humans; Pain

1990

Trials

10 trial(s) available for arginine and Ache

ArticleYear
Safety of intravenous arginine therapy in children with sickle cell disease hospitalized for vaso-occlusive pain: A randomized placebo-controlled trial in progress.
    American journal of hematology, 2022, 01-01, Volume: 97, Issue:1

    Topics: Administration, Intravenous; Adolescent; Adult; Anemia, Sickle Cell; Arginine; Child; Child, Preschool; Hospitalization; Humans; Pain; Placebo Effect; Prospective Studies; Young Adult

2022
Impact of arginine therapy on mitochondrial function in children with sickle cell disease during vaso-occlusive pain.
    Blood, 2020, 09-17, Volume: 136, Issue:12

    Topics: Adolescent; Analgesics, Opioid; Anemia, Sickle Cell; Arginine; Child; Female; Humans; Male; Mitochondria; Oxidative Stress; Pain; Prospective Studies

2020
A randomised controlled trial investigating efficacy of a novel toothpaste containing calcium silicate and sodium phosphate in dentine hypersensitivity pain reduction compared to a fluoride control toothpaste.
    Journal of dentistry, 2020, Volume: 98

    Topics: Adult; Arginine; Calcium Carbonate; Calcium Compounds; Dentin Desensitizing Agents; Dentin Sensitivity; Double-Blind Method; Fluorides; Humans; Pain; Phosphates; Quality of Life; Silicates; Sodium Fluoride; Toothpastes; Treatment Outcome

2020
Randomized clinical trial to determine if changes in dentin tubule occlusion visualized by SEM of replica impressions correlate with pain scores.
    American journal of dentistry, 2018, Volume: 31, Issue:4

    Topics: Arginine; Calcium Carbonate; Dentin; Dentin Desensitizing Agents; Dentin Sensitivity; Fluorides; Humans; Pain; Pain Management; Phosphates; Toothbrushing; Toothpastes; Treatment Outcome

2018
A randomized, placebo-controlled trial of arginine therapy for the treatment of children with sickle cell disease hospitalized with vaso-occlusive pain episodes.
    Haematologica, 2013, Volume: 98, Issue:9

    Topics: Adolescent; Analgesics, Opioid; Anemia, Sickle Cell; Arginine; Child; Double-Blind Method; Female; Hospitalization; Humans; Infusions, Intravenous; Male; Pain; Pain Measurement; Prospective Studies; Treatment Outcome

2013
The effect of arginine or glycine supplementation on gastrointestinal function, muscle injury, serum amino acid concentrations and performance during a marathon run.
    International journal of sports medicine, 1999, Volume: 20, Issue:5

    Topics: Adult; Amino Acids; Arginine; Dietary Supplements; Female; Gastrointestinal Hemorrhage; Glycine; Humans; Intestinal Diseases; Ischemia; Male; Middle Aged; Muscle, Skeletal; Pain; Physical Endurance; Running

1999
Argatroban anticoagulant therapy in patients with heparin-induced thrombocytopenia.
    Circulation, 2001, Apr-10, Volume: 103, Issue:14

    Topics: Aged; Anticoagulants; Arginine; Blood Coagulation; Blood Coagulation Tests; Diarrhea; Exanthema; Female; Hemorrhage; Heparin; Humans; Male; Middle Aged; Pain; Pipecolic Acids; Purpura; Sulfonamides; Thrombocytopenia; Treatment Outcome

2001
A specific thrombin inhibitor, argatroban, alleviates herpes zoster-associated pain.
    The Journal of dermatology, 2001, Volume: 28, Issue:4

    Topics: Aged; Antithrombin III; Antithrombins; Arginine; Female; Herpes Zoster; Humans; Immunohistochemistry; Male; Middle Aged; Pain; Pain Measurement; Peptide Hydrolases; Pipecolic Acids; Prospective Studies; Prothrombin; Statistics, Nonparametric; Sulfonamides; Treatment Outcome; Up-Regulation

2001
Activity and pharmacokinetics of a new oral dosage form of soluble ibuprofen.
    Arzneimittel-Forschung, 1992, Volume: 42, Issue:4

    Topics: Adult; Aged; Arginine; Biological Availability; Double-Blind Method; Female; Humans; Ibuprofen; Male; Middle Aged; Pain; Powders

1992
Controlled trial of haem arginate in acute hepatic porphyria.
    Lancet (London, England), 1989, Jun-10, Volume: 1, Issue:8650

    Topics: Acute Disease; Adolescent; Arginine; Clinical Trials as Topic; Double-Blind Method; Female; Heme; Heroin; Humans; Infusions, Intravenous; Injections, Intravenous; Liver Diseases; Male; Meperidine; Pain; Phlebitis; Porphyrias; Random Allocation; Recurrence; Severity of Illness Index

1989

Other Studies

111 other study(ies) available for arginine and Ache

ArticleYear
Astaxanthin engages the l-arginine/NO/cGMP/KATP channel signaling pathway toward antinociceptive effects.
    Behavioural pharmacology, 2021, 12-01, Volume: 32, Issue:8

    Topics: Analgesics; Animals; Arginine; Cyclic GMP; Disease Models, Animal; Dose-Response Relationship, Drug; Glyburide; KATP Channels; Male; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pain; Signal Transduction; Sildenafil Citrate; Xanthophylls

2021
Revisiting Arginine Therapy for Sickle Cell Acute Vasoocclusive Painful Crisis.
    American journal of respiratory and critical care medicine, 2022, 07-01, Volume: 206, Issue:1

    Topics: Anemia, Sickle Cell; Arginine; Child; Child, Hospitalized; Hemodynamics; Humans; Pain; Prospective Studies

2022
The effects of extremely low-frequency pulsed electromagnetic fields on analgesia in the nitric oxide pathway.
    Nitric oxide : biology and chemistry, 2019, 11-01, Volume: 92

    Topics: Analgesia; Animals; Arginine; Electromagnetic Fields; Injections, Intraperitoneal; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pain; Pain Management; Pyrazoles; Pyridines; Rats; Rats, Wistar; Signal Transduction; Temperature

2019
Affective dimensions of pain and region -specific involvement of nitric oxide in the development of empathic hyperalgesia.
    Scientific reports, 2020, 06-23, Volume: 10, Issue:1

    Topics: Animals; Arginine; Brain; Disease Models, Animal; Empathy; Female; Hyperalgesia; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nociception; Pain; Rats, Wistar

2020
The antinociceptive mechanisms of melatonin: role of L-arginine/nitric oxide/cyclic GMP/KATP channel signaling pathway.
    Behavioural pharmacology, 2020, Volume: 31, Issue:8

    Topics: Analgesics; Animals; Animals, Outbred Strains; Arginine; Cyclic GMP; KATP Channels; Male; Melatonin; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Pain; Signal Transduction

2020
Arginine for mitochondrial oxidative enzymopathy.
    Blood, 2020, 09-17, Volume: 136, Issue:12

    Topics: Anemia, Sickle Cell; Arginine; Child; Humans; Mitochondria; Oxidative Stress; Pain

2020
Bupleurum falcatum L. alleviates nociceptive and neuropathic pain: Potential mechanisms of action.
    Journal of ethnopharmacology, 2021, Jun-12, Volume: 273

    Topics: Animals; Arginine; Bupleurum; Cyclic GMP; Formaldehyde; Hyperalgesia; Iran; Male; Medicine, Traditional; Mice; Nitric Oxide; Oils, Volatile; Pain; Phytotherapy; Plant Oils; Plant Roots; Potassium Channels; Spinal Cord Injuries

2021
Role of l-arginine/SNAP/NO/cGMP/K
    The Journal of pharmacy and pharmacology, 2018, Volume: 70, Issue:4

    Topics: Analgesics; Animals; Arginine; Cyclic GMP; Cyclohexane Monoterpenes; Cyclohexenes; Dose-Response Relationship, Drug; KATP Channels; Male; Mice; Monoterpenes; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pain; Pain Measurement; S-Nitroso-N-Acetylpenicillamine; Signal Transduction; Treatment Outcome

2018
Endomorphin-1 analogs with oligoarginine-conjugation at C-terminus produce potent antinociception with reduced opioid tolerance in paw withdrawal test.
    Peptides, 2018, Volume: 106

    Topics: Analgesics; Analgesics, Opioid; Animals; Arginine; Drug Tolerance; Hindlimb; Hot Temperature; Male; Mice; Models, Animal; Oligopeptides; Pain; Receptors, Opioid, mu

2018
Blockade of analgesic effects following systemic administration of N-methyl-kyotorphin, NMYR and arginine in mice deficient of preproenkephalin or proopiomelanocortin gene.
    Peptides, 2018, Volume: 107

    Topics: Analgesics; Animals; Arginine; CHO Cells; Cricetulus; Enkephalins; Gene Knockout Techniques; Mice; Mice, Inbred C57BL; Neuropeptides; Pain; Pain Management; Pro-Opiomelanocortin; Protein Precursors

2018
Effects of isopulegol in acute nociception in mice: Possible involvement of muscarinic receptors, opioid system and l-arginine/NO/cGMP pathway.
    Chemico-biological interactions, 2018, Sep-25, Volume: 293

    Topics: Acute Disease; Administration, Oral; Analgesics; Animals; Arginine; Behavior, Animal; Capsaicin; Cyclic GMP; Cyclohexane Monoterpenes; Female; Formaldehyde; Glutamic Acid; Male; Mice; Nitric Oxide; Pain; Receptors, Muscarinic; Receptors, Opioid; Signal Transduction; Terpenes

2018
Preventive treatment with dizocilpine attenuates oedema in a carrageenan model of inflammation: the interaction of glutamatergic and nitrergic signaling.
    Inflammopharmacology, 2019, Volume: 27, Issue:1

    Topics: Animals; Anti-Inflammatory Agents; Arginine; Carrageenan; Dizocilpine Maleate; Edema; Inflammation; Isothiuronium; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Pain; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate

2019
Binding of Glyprolines to L-Arginine Inverts Its Analgesic and Antiagressogenic Effects.
    Bulletin of experimental biology and medicine, 2018, Volume: 165, Issue:5

    Topics: Aggression; Analgesics; Animals; Arginine; Dose-Response Relationship, Drug; Electroshock; Injections, Intraperitoneal; Male; Oligopeptides; Pain; Proline; Protein Binding; Rats; Rats, Wistar; Structure-Activity Relationship; Tranquilizing Agents

2018
Antinociceptive and anti-inflammatory properties of Tetracera alnifolia Willd. (Dilleniaceae) hydroethanolic leaf extract.
    Journal of basic and clinical physiology and pharmacology, 2018, Oct-17, Volume: 30, Issue:2

    Topics: Analgesics; Animals; Anti-Inflammatory Agents; Arginine; Arthritis; Carrageenan; Dilleniaceae; Edema; Glyburide; Male; Medicine, African Traditional; Mice; Naloxone; Pain; Pain Measurement; Phytotherapy; Plant Extracts; Plant Leaves; Rats

2018
Opposing roles of corticotropin-releasing factor and neuropeptide Y within the dorsolateral bed nucleus of the stria terminalis in the negative affective component of pain in rats.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013, Apr-03, Volume: 33, Issue:14

    Topics: Action Potentials; Affective Symptoms; Analysis of Variance; Aniline Compounds; Animals; Arginine; Corticotropin-Releasing Hormone; Cyclohexanes; Disease Models, Animal; Excitatory Amino Acid Antagonists; Formaldehyde; GABA Antagonists; Hormone Antagonists; Hormones; In Vitro Techniques; Kynurenic Acid; Male; Membrane Potentials; Microdialysis; Neurons; Neuropeptide Y; Pain; Pain Measurement; Peptide Fragments; Pyridazines; Pyrimidines; Rats; Rats, Sprague-Dawley; Septal Nuclei; Xanthenes

2013
Evaluation of mechanisms involved in the antinociception of the ethanol extract from the inner bark of Caesalpinia pyramidalis in mice.
    Journal of ethnopharmacology, 2013, Jun-21, Volume: 148, Issue:1

    Topics: Acetic Acid; Analgesics; Animals; Arginine; Behavior, Animal; Caesalpinia; Capsaicin; Ethanol; Female; Glutamic Acid; Male; Mice; Nitric Oxide; Pain; Phytotherapy; Plant Bark; Plant Extracts; Solvents

2013
Ang-(1-7) activates the NO/cGMP and ATP-sensitive K+ channels pathway to induce peripheral antinociception in rats.
    Nitric oxide : biology and chemistry, 2014, Feb-15, Volume: 37

    Topics: Adenosine Triphosphate; Analgesics; Angiotensin I; Animals; Arginine; Cyclic GMP; Dinoprostone; Dose-Response Relationship, Drug; Hyperalgesia; KATP Channels; Male; Nitric Oxide; Pain; Pain Measurement; Peptide Fragments; Rats; Rats, Wistar

2014
Nitric oxide synthase modulates the antihyperalgesic effect of the NMDA receptor antagonist MK-801 on Carrageenan-induced inflammatory pain in rats.
    The Tohoku journal of experimental medicine, 2014, Volume: 234, Issue:4

    Topics: Animals; Arginine; Carrageenan; Dizocilpine Maleate; Hyperalgesia; Inflammation; Isothiuronium; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Pain; Pain Threshold; Rats, Wistar; Receptors, N-Methyl-D-Aspartate

2014
Intrathecal L-arginine reduces the antinociception of sevoflurane in formalin-induced pain in rats.
    Neuroscience letters, 2015, Mar-17, Volume: 590

    Topics: Anesthetics, Inhalation; Animals; Arginine; Injections, Spinal; Methyl Ethers; Neurons; Nitric Oxide; Nociception; Pain; Pain Measurement; Proto-Oncogene Proteins c-fos; Rats, Sprague-Dawley; Sevoflurane; Spinal Cord

2015
Analgesia and unwanted benzodiazepine effects in point-mutated mice expressing only one benzodiazepine-sensitive GABAA receptor subtype.
    Nature communications, 2015, Apr-13, Volume: 6

    Topics: Analgesia; Animals; Arginine; Benzodiazepines; Diazepam; GABA Modulators; Gene Expression; Histidine; Hyperalgesia; Hypnotics and Sedatives; Male; Mice; Midazolam; Pain; Pain Management; Point Mutation; Receptors, GABA-A; Spinal Cord

2015
Thalidomide attenuates the development and expression of antinociceptive tolerance to μ-opioid agonist morphine through l-arginine-iNOS and nitric oxide pathway.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2017, Volume: 85

    Topics: Animals; Arginine; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Tolerance; Gene Expression Regulation; Hot Temperature; Humans; Immunosuppressive Agents; Male; Mice; Morphine; Nitric Oxide; Nitric Oxide Synthase Type II; Pain; Pain Measurement; Thalidomide

2017
Y1 receptor knockout increases nociception and prevents the anti-allodynic actions of NPY.
    Nutrition (Burbank, Los Angeles County, Calif.), 2008, Volume: 24, Issue:9

    Topics: Analgesics; Animals; Anti-Inflammatory Agents; Arginine; Behavior, Animal; Disease Models, Animal; Hot Temperature; Hyperalgesia; Inflammation; Male; Mice; Mice, Knockout; Neuropeptide Y; Pain; Pain Measurement; Receptors, Neuropeptide Y; Sciatic Neuropathy

2008
Further analysis of the antinociceptive action caused by p-methoxyl-diphenyl diselenide in mice.
    Pharmacology, biochemistry, and behavior, 2009, Volume: 91, Issue:4

    Topics: Analgesics; Animals; Arginine; Benzazepines; Benzene Derivatives; Bradykinin; Dopamine Antagonists; Enzyme Inhibitors; Glutamic Acid; Magnetic Resonance Spectroscopy; Male; Mice; Neurotransmitter Agents; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Organoselenium Compounds; Pain; Receptors, Neurotransmitter; Tetradecanoylphorbol Acetate

2009
Effects of NO-modulating agents on the development of acute painful reaction in rats.
    Bulletin of experimental biology and medicine, 2008, Volume: 146, Issue:2

    Topics: Agmatine; Animals; Arginine; Behavior, Animal; Formaldehyde; Inflammation; Injections, Intraperitoneal; Male; Nitric Oxide; Nitroarginine; Pain; Pain Measurement; Rats; Rats, Wistar; Spectrophotometry

2008
[Effect of a simple morphine system injection in some aminoacids in the anterior cingulate cortex during acute pain].
    Investigacion clinica, 2008, Volume: 49, Issue:4

    Topics: Acute Disease; Amino Acids; Analgesics, Opioid; Animals; Arginine; Aspartic Acid; Cerebral Cortex; Disinfectants; Formaldehyde; gamma-Aminobutyric Acid; Glutamic Acid; Gyrus Cinguli; Male; Microdialysis; Morphine; Pain; Rats; Rats, Wistar

2008
Mechanisms involved in the antinociception caused by ethanolic extract obtained from the leaves of Melissa officinalis (lemon balm) in mice.
    Pharmacology, biochemistry, and behavior, 2009, Volume: 93, Issue:1

    Topics: Acetic Acid; Analgesics; Animals; Arginine; Atropine; Cinnamates; Depsides; Dose-Response Relationship, Drug; Female; Formaldehyde; Glutamic Acid; Male; Mecamylamine; Melissa; Mice; Motor Activity; Naloxone; Nitric Oxide; Pain; Pain Threshold; Phytotherapy; Plant Extracts; Plant Leaves; Receptors, Muscarinic; Receptors, Nicotinic; Rosmarinic Acid

2009
Intracerebroventricular administration of 26RFa produces an analgesic effect in the rat formalin test.
    Peptides, 2009, Volume: 30, Issue:9

    Topics: Analgesics, Non-Narcotic; Animals; Anti-Anxiety Agents; Arginine; Formaldehyde; Hot Temperature; Injections, Intraventricular; Male; Narcotic Antagonists; Neuropeptide Y; Neuropeptides; Oligopeptides; Pain; Pain Measurement; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, G-Protein-Coupled; Spinal Cord

2009
Opposing actions of neuronal nitric oxide synthase isoforms in formalin-induced pain in mice.
    Brain research, 2009, Sep-15, Volume: 1289

    Topics: Analysis of Variance; Animals; Arginine; Drug Tolerance; Formaldehyde; Hyperalgesia; Injections, Spinal; Isoenzymes; Male; Mice; Morphine; Nitric Oxide Synthase Type I; Nitroarginine; Oligodeoxyribonucleotides, Antisense; Pain; Pain Measurement; Pain Threshold

2009
Antinociceptive effects of (O-methyl)-N-benzoyl tyramine (riparin I) from Aniba riparia (Nees) Mez (Lauraceae) in mice.
    Naunyn-Schmiedeberg's archives of pharmacology, 2009, Volume: 380, Issue:4

    Topics: Acetic Acid; Administration, Oral; Analgesics; Analgesics, Opioid; Animals; Arginine; Behavior, Animal; Benzamides; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Formaldehyde; Hot Temperature; Injections, Intraperitoneal; Lauraceae; Male; Mice; Morphine; Naloxone; Narcotic Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Pain; Pain Measurement; Reaction Time; Time Factors; Tyramine

2009
Gonadal hormones decrease temporomandibular joint kappa-mediated antinociception through a down-regulation in the expression of kappa opioid receptors in the trigeminal ganglia.
    European journal of pharmacology, 2009, Sep-01, Volume: 617, Issue:1-3

    Topics: Analgesics; Animals; Arginine; Cyclic GMP; Down-Regulation; Female; Gonadal Hormones; Humans; Male; Nitric Oxide; omega-N-Methylarginine; Oxadiazoles; Pain; Quinoxalines; Rats; Rats, Wistar; Receptors, Opioid, kappa; Sex Characteristics; Signal Transduction; Temporomandibular Joint; Trigeminal Ganglion

2009
Role of nitric oxide in the rat hippocampal CA1 in morphine antinociception.
    Brain research, 2010, Feb-08, Volume: 1313

    Topics: Analgesics, Opioid; Animals; Arginine; CA1 Region, Hippocampal; Central Nervous System Agents; Dose-Response Relationship, Drug; Enzyme Inhibitors; Formaldehyde; Inflammation; Male; Morphine; NADPH Dehydrogenase; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Pain; Pain Measurement; Rats; Rats, Wistar; Time Factors

2010
Effects of multiple intrathecal administration of L-arginine with different doses on formalin-induced nociceptive behavioral responses in rats.
    Neuroscience bulletin, 2010, Volume: 26, Issue:3

    Topics: Animals; Arginine; Behavior, Animal; Cell Count; Central Nervous System Agents; Dose-Response Relationship, Drug; Formaldehyde; Hindlimb; Immunohistochemistry; Injections, Spinal; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Pain; Photomicrography; Posterior Horn Cells; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Time Factors

2010
Synthesis and antinociceptive effects of endomorphin-1 analogs with C-terminal linked by oligoarginine.
    Peptides, 2011, Volume: 32, Issue:2

    Topics: Analgesics, Opioid; Animals; Arginine; Brain; Chromatography, High Pressure Liquid; Female; Guinea Pigs; Ileum; Male; Mice; Mice, Inbred Strains; Muscle Contraction; Naloxone; Oligopeptides; Pain; Pain Measurement; Radioligand Assay; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu; Spectrometry, Mass, Electrospray Ionization; Vas Deferens

2011
Possible participation of nitric oxide/cyclic guanosine monophosphate/protein kinase C/ATP-sensitive K(+) channels pathway in the systemic antinociception of flavokawin B.
    Basic & clinical pharmacology & toxicology, 2011, Volume: 108, Issue:6

    Topics: Analgesics; Animals; Arginine; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Glyburide; Hypoglycemic Agents; Male; Methylene Blue; Mice; Mice, Inbred ICR; Nitric Oxide; Nitric Oxide Synthase; Pain; Potassium Channels; Protein Kinase C; Signal Transduction

2011
Taking pain out of NGF: a "painless" NGF mutant, linked to hereditary sensory autonomic neuropathy type V, with full neurotrophic activity.
    PloS one, 2011, Feb-28, Volume: 6, Issue:2

    Topics: Amino Acid Substitution; Animals; Arginine; BALB 3T3 Cells; Cells, Cultured; Chick Embryo; Genetic Predisposition to Disease; Hereditary Sensory and Autonomic Neuropathies; Humans; Male; Mice; Mutant Proteins; Nerve Growth Factors; Pain; Pain Perception; PC12 Cells; Rats; Receptor, Nerve Growth Factor; Sensory Receptor Cells; Tryptophan

2011
Neuronal nitric oxide synthase is involved in the induction of nerve growth factor-induced neck muscle nociception.
    Headache, 2011, Volume: 51, Issue:5

    Topics: Animals; Arginine; Brain Stem; Disease Models, Animal; Electric Stimulation; Enzyme Inhibitors; Male; Mice; Mice, Inbred C57BL; Neck Muscles; Nerve Growth Factor; Nitric Oxide Synthase Type I; Pain; Reflex; Tension-Type Headache

2011
Tonic inhibition of chronic pain by neuropeptide Y.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Apr-26, Volume: 108, Issue:17

    Topics: Animals; Arginine; Behavior, Animal; Benzazepines; Chronic Disease; Gene Expression Regulation; Mice; Mice, Knockout; Neuropeptide Y; Nociceptors; Pain; Posterior Horn Cells; Proto-Oncogene Proteins c-fos; Receptors, Neuropeptide Y; Synaptic Transmission

2011
Antinociceptive effect of the essential oil of Zingiber zerumbet in mice: possible mechanisms.
    Journal of ethnopharmacology, 2011, Sep-01, Volume: 137, Issue:1

    Topics: Administration, Oral; Analgesics; Animals; Arginine; Behavior, Animal; Cyclic GMP; Disease Models, Animal; Dose-Response Relationship, Drug; Glutamic Acid; Injections, Intraperitoneal; KATP Channels; Male; Medicine, Traditional; Mice; Mice, Inbred ICR; Neural Pathways; Nitric Oxide; Oils, Volatile; Pain; Pain Measurement; Pain Threshold; Plant Oils; Plant Roots; Plants, Medicinal; Protein Kinase C; Signal Transduction; TRPV Cation Channels; Zingiber officinale

2011
The acute effects of mirtazapine on pain related behavior in healthy animals.
    Neurosciences (Riyadh, Saudi Arabia), 2011, Volume: 16, Issue:3

    Topics: Analysis of Variance; Animals; Antidepressive Agents, Tricyclic; Arginine; Behavior, Animal; Cyproheptadine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Female; Gene Expression Regulation, Enzymologic; Hippocampus; In Vitro Techniques; Male; Mianserin; Mice; Mirtazapine; Naloxone; Narcotic Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type I; Pain; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Serotonin Antagonists

2011
Ketamine activates the L-arginine/Nitric oxide/cyclic guanosine monophosphate pathway to induce peripheral antinociception in rats.
    Anesthesia and analgesia, 2011, Volume: 113, Issue:5

    Topics: Analgesia; Anesthetics, Dissociative; Animals; Arginine; Cyclic AMP; Dinoprostone; Drug Synergism; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Guanylate Cyclase; Hyperalgesia; Ketamine; Male; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Oxadiazoles; Pain; Peripheral Nervous System Diseases; Quinoxalines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Signal Transduction

2011
Asymmetric dimethylarginine may mediate increased heat pain threshold in experimental chronic kidney disease.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2012, Volume: 27, Issue:3

    Topics: Animals; Arginine; Enzyme Inhibitors; Hot Temperature; Kidney Failure, Chronic; Male; Nephrectomy; Nitric Oxide Synthase; Pain; Pain Threshold; Rats; Rats, Sprague-Dawley

2012
Different effects of L-arginine on morphine tolerance in sham and ovariectomized female mice.
    Journal of Zhejiang University. Science. B, 2011, Volume: 12, Issue:12

    Topics: Analgesics, Opioid; Animals; Arginine; Drug Interactions; Drug Tolerance; Female; Gonadal Hormones; Mice; Mice, Inbred BALB C; Morphine; Nitric Oxide; Ovariectomy; Pain

2011
Involvement of the L-arginine-nitric oxide pathway in the antinociception caused by fruits of Prosopis strombulifera (Lam.) Benth.
    Journal of ethnopharmacology, 2012, Mar-06, Volume: 140, Issue:1

    Topics: Analgesics; Animals; Anti-Inflammatory Agents; Argentina; Arginine; Aspirin; Cell Line; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Fruit; Macrophages; Male; Medicine, Traditional; Mice; Mice, Inbred Strains; Morphine; Nitric Oxide; Nitric Oxide Synthase Type II; Pain; Phytotherapy; Plant Extracts; Prosopis

2012
NO/cGMP production is important for the endogenous peripheral control of hyperalgesia during inflammation.
    Nitric oxide : biology and chemistry, 2013, Jan-15, Volume: 28

    Topics: Animals; Arginine; Carrageenan; Cyclic GMP; Dinoprostone; Hyperalgesia; Inflammation; Male; Nitric Oxide; Pain; Pain Measurement; Pressure; Rats; Rats, Wistar

2013
Antinociceptive activity of carvacrol (5-isopropyl-2-methylphenol) in mice.
    The Journal of pharmacy and pharmacology, 2012, Volume: 64, Issue:12

    Topics: Abdominal Pain; Acetic Acid; Analgesics; Animals; Arginine; Behavior, Animal; Cymenes; Disease Models, Animal; Formaldehyde; Hot Temperature; Male; Mice; Mice, Inbred Strains; Monoterpenes; Motor Activity; Naloxone; Narcotic Antagonists; Oils, Volatile; Origanum; Pain; Phytotherapy; Plant Extracts; Thymus Plant

2012
Are advanced glycation end-product-modified proteins of pathogenetic importance in fibromyalgia?
    Rheumatology (Oxford, England), 2002, Volume: 41, Issue:10

    Topics: Adult; Arginine; Collagen; Cross-Linking Reagents; Female; Fibromyalgia; Glycation End Products, Advanced; Humans; Lysine; Male; Middle Aged; Oxidative Stress; Pain

2002
The kappa-opioid agonist (+/-)-bremazocine elicits peripheral antinociception by activation of the L-arginine/nitric oxide/cyclic GMP pathway.
    European journal of pharmacology, 2002, Nov-01, Volume: 454, Issue:1

    Topics: Analgesics; Animals; Arginine; Benzomorphans; Cyclic GMP; Guanylate Cyclase; Hyperalgesia; Male; Methylene Blue; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Pain; Phosphodiesterase Inhibitors; Purinones; Rats; Rats, Wistar; Receptors, Opioid, kappa

2002
NOS inhibitors exhibit antinociceptive properties in the rat formalin test.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2003, Volume: 50, Issue:9

    Topics: Analgesics; Animals; Arginine; Blood Pressure; Enzyme Inhibitors; Formaldehyde; Guanidines; Heart Rate; Indazoles; Nitric Oxide Synthase; Nitroarginine; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Sodium Chloride; Time Factors

2003
Acute pancreatitis results in referred mechanical hypersensitivity and neuropeptide up-regulation that can be suppressed by the protein kinase inhibitor k252a.
    The journal of pain, 2003, Volume: 4, Issue:6

    Topics: Animals; Arginine; Calcitonin Gene-Related Peptide; Carbazoles; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Ganglia, Spinal; Indole Alkaloids; Male; Neurons, Afferent; Nociceptors; Pain; Pain Threshold; Pancreatitis, Acute Necrotizing; Phosphorylation; Physical Stimulation; Protein Kinase C; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptor, trkA; RNA, Messenger; Spinal Cord; Substance P; Tachykinins; Up-Regulation

2003
Reduction in [D-Ala2, NMePhe4, Gly-ol5]enkephalin-induced peripheral antinociception in diabetic rats: the role of the L-arginine/nitric oxide/cyclic guanosine monophosphate pathway.
    Anesthesia and analgesia, 2004, Volume: 98, Issue:1

    Topics: Analgesics, Opioid; Animals; Arginine; Blood Glucose; Cyclic GMP; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enzyme Inhibitors; Formaldehyde; Guanylate Cyclase; Male; Methylene Blue; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Pain; Pain Measurement; Rats; Rats, Wistar

2004
Involvement of peripheral neuropeptide Y receptors in sympathetic modulation of acute cutaneous flare induced by intradermal capsaicin.
    Neuroscience, 2004, Volume: 123, Issue:2

    Topics: Animals; Arginine; Benzazepines; Bicuculline; Capsaicin; Foot; GABA Antagonists; Inflammation; Injections, Spinal; Laser-Doppler Flowmetry; Male; Pain; Rats; Rats, Sprague-Dawley; Receptors, Neuropeptide Y; Skin; Spinal Cord; Sympathectomy; Sympathetic Nervous System

2004
Participation of the NO-cyclic GMP pathway in rofecoxib-induced antinociception.
    Proceedings of the Western Pharmacology Society, 2003, Volume: 46

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arginine; Cyclic GMP; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Guanylate Cyclase; Isoenzymes; Lactones; Molsidomine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Oxadiazoles; Pain; Prostaglandin-Endoperoxide Synthases; Quinoxalines; Rats; Rats, Wistar; Sulfones; Uric Acid

2003
Differential release of neurotransmitters from superficial and deep layers of the dorsal horn in response to acute noxious stimulation and inflammation of the rat paw.
    European journal of pain (London, England), 2004, Volume: 8, Issue:3

    Topics: Afferent Pathways; Animals; Arginine; Aspartic Acid; Chondrus; Extracellular Fluid; Foot; gamma-Aminobutyric Acid; Glutamic Acid; Inflammation; Male; Microdialysis; Neurotransmitter Agents; Pain; Posterior Horn Cells; Presynaptic Terminals; Rats; Rats, Wistar; Reaction Time; Synaptic Transmission; Up-Regulation

2004
Effect of D-arginine on antinociception induced by kyotorphin, Tyr-cav, L-cav and Tyr(Cl2)-cav in rats.
    Methods and findings in experimental and clinical pharmacology, 2004, Volume: 26, Issue:5

    Topics: Analgesics; Animals; Arginine; Canavanine; Endorphins; Male; Pain; Pain Measurement; Rats; Rats, Wistar; Stereoisomerism

2004
Peripheral involvement of the nitric oxide-cGMP pathway in the indomethacin-induced antinociception in rat.
    European journal of pharmacology, 2004, Oct-25, Volume: 503, Issue:1-3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arginine; Chronic Disease; Cyclic GMP; Disease Models, Animal; Enzyme Inhibitors; Female; Gout; Indomethacin; Nerve Tissue Proteins; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitroprusside; Pain; Pain Measurement; Peripheral Nervous System; Rats; Rats, Wistar; Signal Transduction; Uric Acid

2004
Involvement of 5-HT2 receptors in the antinociceptive effect of Uncaria tomentosa.
    Pharmacology, biochemistry, and behavior, 2005, Volume: 81, Issue:3

    Topics: Acetic Acid; Analgesics; Animals; Arginine; Atropine; Behavior, Animal; Capsaicin; Cat's Claw; Dose-Response Relationship, Drug; Formaldehyde; Ketanserin; Male; Mice; Motor Activity; Naltrexone; Pain; Pain Measurement; Phytotherapy; Plant Preparations; Prazosin; Receptors, Serotonin, 5-HT2; Reserpine; Serotonin 5-HT2 Receptor Antagonists; Serotonin Antagonists; Yohimbine

2005
Involvement of nitric oxide in clonidine-induced spinal analgesia.
    Drug metabolism and drug interactions, 2005, Volume: 21, Issue:1

    Topics: Acute Disease; Analgesia; Analgesics; Animals; Arginine; Clonidine; Injections, Spinal; Male; Methylene Blue; Mice; Mice, Inbred ICR; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroglycerin; Pain

2005
Cerebroventricular injection of clonidine causes analgesia mediated by a nitrogen pathway.
    Drug metabolism and drug interactions, 2005, Volume: 21, Issue:1

    Topics: Acute Disease; Analgesia; Analgesics; Animals; Arginine; Cerebral Ventricles; Clonidine; Injections; Male; Methylene Blue; Mice; Mice, Inbred ICR; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroglycerin; Pain; Random Allocation

2005
Possible involvement of the spinal nitric oxide/cGMP pathway in vincristine-induced painful neuropathy in mice.
    Pain, 2005, Volume: 117, Issue:1-2

    Topics: Analysis of Variance; Animals; Arginine; Blotting, Western; Cyclic GMP; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Injections, Spinal; Male; Mice; Mice, Inbred ICR; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxadiazoles; Pain; Pain Measurement; Quinoxalines; Reaction Time; Spinal Cord; Time Factors; Vincristine

2005
Analysis of the antinociceptive effect of the flavonoid myricitrin: evidence for a role of the L-arginine-nitric oxide and protein kinase C pathways.
    The Journal of pharmacology and experimental therapeutics, 2006, Volume: 316, Issue:2

    Topics: Administration, Oral; Analgesics, Non-Narcotic; Animals; Arginine; Blotting, Western; Female; Flavonoids; Hyperalgesia; Injections, Intraperitoneal; Male; Mice; Motor Activity; Nitric Oxide; Pain; Pain Measurement; Protein Kinase C; Rats; Rats, Wistar

2006
Transient receptor potential vanilloid 1, calcitonin gene-related peptide, and substance P mediate nociception in acute pancreatitis.
    American journal of physiology. Gastrointestinal and liver physiology, 2006, Volume: 290, Issue:5

    Topics: Animals; Arginine; Calcitonin Gene-Related Peptide; Capsaicin; Male; Neurons, Afferent; Pain; Pain Measurement; Pancreas; Pancreatitis; Rats; Rats, Sprague-Dawley; Receptors, Calcitonin Gene-Related Peptide; Spinal Cord; Spinal Nerves; Substance P; TRPV Cation Channels

2006
Calcitonin gene-related peptide partially mediates nociception in acute experimental pancreatitis.
    Surgery, 2006, Volume: 139, Issue:2

    Topics: Acute Disease; Animals; Arginine; Calcitonin Gene-Related Peptide; Disease Models, Animal; Male; Necrosis; Pain; Pancreatitis; Posterior Horn Cells; Rats; Rats, Sprague-Dawley

2006
Antinociceptive properties of the ethanolic extract and of the triterpene 3beta,6beta,16beta-trihidroxilup-20(29)-ene obtained from the flowers of Combretum leprosum in mice.
    Pharmacology, biochemistry, and behavior, 2006, Volume: 83, Issue:1

    Topics: Acetic Acid; Analgesics; Animals; Arginine; Capsaicin; Combretum; Endorphins; Flowers; Formaldehyde; Glutamic Acid; Male; Mice; Motor Activity; Nitric Oxide; Pain; Pain Measurement; Plant Extracts; Psychomotor Performance; Reaction Time; Serotonin; Triterpenes

2006
Defensive-like behaviors and antinociception induced by NMDA injection into the periaqueductal gray of mice depend on nitric oxide synthesis.
    Brain research, 2006, Mar-03, Volume: 1076, Issue:1

    Topics: Analysis of Variance; Animals; Arginine; Behavior, Animal; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Freezing Reaction, Cataleptic; Male; Mice; N-Methylaspartate; Nitric Oxide Synthase; Pain; Pain Measurement; Periaqueductal Gray; Reaction Time; Running

2006
Attenuation of morphine tolerance and dependence by aminoguanidine in mice.
    European journal of pharmacology, 2006, Jul-01, Volume: 540, Issue:1-3

    Topics: Analgesics; Analgesics, Opioid; Animals; Arginine; Behavior, Animal; Brain; Dizocilpine Maleate; Drug Tolerance; Enzyme Inhibitors; Glutamates; Guanidines; Male; Mice; Morphine; Morphine Dependence; Naloxone; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitrites; Pain; Pain Measurement; Time Factors

2006
The antinociceptive activity of Muntingia calabura aqueous extract and the involvement of L-arginine/nitric oxide/cyclic guanosine monophosphate pathway in its observed activity in mice.
    Fundamental & clinical pharmacology, 2006, Volume: 20, Issue:4

    Topics: Acetic Acid; Analgesics; Animals; Arginine; Cyclic GMP; Dose-Response Relationship, Drug; Elaeocarpaceae; Enzyme Inhibitors; Guanylate Cyclase; Male; Methylene Blue; Mice; Mice, Inbred BALB C; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Pain; Pain Measurement; Plant Extracts; Plant Leaves; Signal Transduction

2006
Peripheral antinociceptive effect of pertussis toxin: activation of the arginine/NO/cGMP/PKG/ ATP-sensitive K channel pathway.
    The European journal of neuroscience, 2006, Volume: 24, Issue:4

    Topics: Adenosine Triphosphate; Analgesia; Analgesics; Animals; Arginine; Bucladesine; Carbazoles; Cells, Cultured; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Dinoprostone; Enzyme Inhibitors; Ganglia, Spinal; Glyburide; Indoles; KATP Channels; Male; Neurons; Nitric Oxide; omega-N-Methylarginine; Oxadiazoles; Pain; Pain Measurement; Pertussis Toxin; Potassium Channels, Inwardly Rectifying; Quinoxalines; Rats; Rats, Wistar; Signal Transduction; Tolbutamide

2006
Design and characterization of a noncompetitive antagonist of the transient receptor potential vanilloid subunit 1 channel with in vivo analgesic and anti-inflammatory activity.
    The journal of pain, 2006, Volume: 7, Issue:10

    Topics: Analgesics; Animals; Anti-Inflammatory Agents; Arginine; Capsaicin; Chlorocebus aethiops; COS Cells; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Design; Female; Glycine; Inflammation; Ion Channels; Male; Mice; Mice, Inbred ICR; Nociceptors; Oocytes; Pain; Patch-Clamp Techniques; Rats; Rats, Wistar; Sensory Receptor Cells; TRPV Cation Channels; Xenopus

2006
Identification of the alpha2-delta-1 subunit of voltage-dependent calcium channels as a molecular target for pain mediating the analgesic actions of pregabalin.
    Proceedings of the National Academy of Sciences of the United States of America, 2006, Nov-14, Volume: 103, Issue:46

    Topics: Amino Acid Sequence; Analgesics; Animals; Arginine; Autoradiography; Base Sequence; Calcium Channels; Calcium Channels, N-Type; Cell Line; Chlorocebus aethiops; Constriction, Pathologic; Female; Formaldehyde; gamma-Aminobutyric Acid; Ion Channel Gating; Male; Mice; Mice, Transgenic; Mutation; Pain; Pregabalin; Protein Binding; Protein Subunits; Swine

2006
[Extracellular aminoacids in the amygdala and nucleus accumbens in the rat during acute pain].
    Investigacion clinica, 2007, Volume: 48, Issue:2

    Topics: Acute Disease; Amygdala; Animals; Arginine; Aspartic Acid; Glutamic Acid; Male; Nucleus Accumbens; Pain; Rats; Rats, Wistar

2007
The role of nitric oxide in diabetes-induced changes of morphine tolerance in rats.
    European journal of pharmacology, 2007, Sep-10, Volume: 570, Issue:1-3

    Topics: Analgesics, Opioid; Animals; Arginine; Diabetes Mellitus, Experimental; Drug Tolerance; Guanidines; Hot Temperature; Male; Morphine; Nitric Oxide; Nitric Oxide Synthase Type II; Nitrites; Pain; Rats; Rats, Sprague-Dawley

2007
Twenty-four-hour variation of L-arginine/nitric oxide/cyclic guanosine monophosphate pathway demonstrated by the mouse visceral pain model.
    Chronobiology international, 2007, Volume: 24, Issue:3

    Topics: Abdominal Pain; Analgesics; Animals; Arginine; Benzoquinones; Circadian Rhythm; Cyclic GMP; Enzyme Inhibitors; Male; Methylene Blue; Mice; Mice, Inbred Strains; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitrites; Nitroprusside; Pain; Pain Measurement; Signal Transduction

2007
Antinociceptive effect from Davilla elliptica hydroalcoholic extract.
    Journal of ethnopharmacology, 2007, Sep-05, Volume: 113, Issue:2

    Topics: Administration, Oral; Analgesics; Animals; Arginine; Behavior, Animal; Brazil; Cyclooxygenase Inhibitors; Diclofenac; Dilleniaceae; Enzyme Inhibitors; Ethanol; Formaldehyde; Hindlimb; Male; Medicine, Traditional; Mice; NG-Nitroarginine Methyl Ester; Pain; Pain Measurement; Plant Components, Aerial; Plant Extracts; Water

2007
[Metabolic decrease of the motor neuron excitability].
    Der Nervenarzt, 1967, Volume: 38, Issue:8

    Topics: Acid-Base Equilibrium; Alkalosis; Arginine; Calcium Chloride; Electrolytes; Female; Humans; Lysine; Magnesium; Middle Aged; Motor Neurons; Neuromuscular Junction; Pain; Spasm

1967
Systemic N-nitro-L-arginine-ester (L-NAME), inhibitor of nitric oxide synthase, relieves chronic allodynia-like symptom in rats with spinal cord lesion.
    Acta physiologica Scandinavica, 1994, Volume: 150, Issue:4

    Topics: Amino Acid Oxidoreductases; Animals; Arginine; Female; Injections, Intraperitoneal; Ischemia; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Pain; Palliative Care; Pressure; Rats; Rats, Sprague-Dawley; Spinal Cord

1994
The NO-cGMP pathway in neonatal rat dorsal horn.
    The European journal of neuroscience, 1994, May-01, Volume: 6, Issue:5

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Oxidoreductases; Animals; Animals, Newborn; Arginine; Biomarkers; Cyclic GMP; Female; Glutathione; Male; N-Methylaspartate; NADPH Dehydrogenase; Nerve Tissue Proteins; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Nitroprusside; Nitroso Compounds; Pain; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; S-Nitrosoglutathione; Second Messenger Systems; Signal Transduction; Spinal Cord

1994
Effect of topical administration of L-arginine on formalin-induced nociception in the mouse: a dual role of peripherally formed NO in pain modulation.
    British journal of pharmacology, 1994, Volume: 112, Issue:2

    Topics: Administration, Topical; Amino Acid Oxidoreductases; Animals; Arginine; Behavior, Animal; Dose-Response Relationship, Drug; Formaldehyde; Male; Mice; Mice, Inbred Strains; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Pain; Pain Measurement; Stereoisomerism

1994
Intracellular messengers contributing to persistent nociception and hyperalgesia induced by L-glutamate and substance P in the rat formalin pain model.
    The European journal of neuroscience, 1994, Aug-01, Volume: 6, Issue:8

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arachidonic Acid; Arginine; Dexamethasone; Formaldehyde; Glutamic Acid; Hyperalgesia; Injections, Spinal; Isoquinolines; Male; Neurotransmitter Agents; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nociceptors; Pain; Pain Measurement; Pain Threshold; Piperazines; Protein Kinase C; Rats; Reflex; Substance P

1994
Topical spinal administration of a nitric oxide synthase inhibitor prevents the hyper-reflexia associated with a rat model of persistent visceral pain.
    Neuroscience letters, 1995, Mar-03, Volume: 187, Issue:2

    Topics: Amino Acid Oxidoreductases; Analgesics; Anilides; Animals; Arginine; Cystitis; Female; Injections, Spinal; Nitric Oxide Synthase; Pain; Rats; Rats, Wistar; Reflex; Reflex, Abnormal; Turpentine; Urinary Bladder; Viscera

1995
Nitric oxide mediates allodynia induced by intrathecal administration of prostaglandin E2 or prostaglandin F2 alpha in conscious mice.
    Pain, 1995, Volume: 61, Issue:2

    Topics: Analysis of Variance; Animals; Arginine; Dinoprost; Dinoprostone; Dose-Response Relationship, Drug; Injections, Spinal; Male; Methylene Blue; Mice; Mice, Inbred Strains; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pain; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission

1995
L-NG-nitro arginine p-nitroanilide (L-NAPNA) is anti-nociceptive in the mouse.
    Neuroreport, 1993, Volume: 4, Issue:3

    Topics: Amino Acid Oxidoreductases; Analgesics; Anilides; Animals; Aorta, Thoracic; Arginine; Blood Pressure; Brain; Formaldehyde; In Vitro Techniques; Male; Mice; Muscle Contraction; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; omega-N-Methylarginine; Pain; Rabbits; Rats; Rats, Sprague-Dawley

1993
Nitric oxide synthase inhibitor blocks spinal sensitization induced by formalin injection into the rat paw.
    Anesthesia and analgesia, 1993, Volume: 77, Issue:5

    Topics: Amino Acid Oxidoreductases; Animals; Arginine; Dose-Response Relationship, Drug; Formaldehyde; Inflammation; Injections, Spinal; Male; Nitric Oxide Synthase; Nitroarginine; Pain; Rats; Rats, Sprague-Dawley; Spinal Cord

1993
Nitric oxide mediates neuropathic pain behavior in peripherally denervated rats.
    Neuroscience letters, 1995, Mar-16, Volume: 188, Issue:1

    Topics: Animals; Arginine; Behavior, Animal; Cyclic AMP; Denervation; Disease Models, Animal; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pain; Peripheral Nerves; Phantom Limb; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Spinal Cord; Stereoisomerism; Synaptic Transmission; Time Factors

1995
Characterization of the role of spinal N-methyl-D-aspartate receptors in thermal nociception in the rat.
    Neuroscience, 1993, Volume: 57, Issue:2

    Topics: 2-Amino-5-phosphonovalerate; Animals; Arginine; Behavior, Animal; Cold Temperature; Hot Temperature; Male; Methysergide; N-Methylaspartate; Nitroarginine; Nociceptors; Pain; Phentolamine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reflex; Spinal Cord

1993
Analysis of the role of endothelin-A and endothelin-B receptors on nociceptive information transmission in the spinal cord with FR139317, an endothelin-A receptor antagonist, and sarafotoxin S6c, an endothelin-B receptor agonist.
    The Journal of pharmacology and experimental therapeutics, 1994, Volume: 271, Issue:1

    Topics: Animals; Arginine; Azepines; Behavior, Animal; Endothelin Receptor Antagonists; Endothelins; Formaldehyde; Indoles; Male; NG-Nitroarginine Methyl Ester; Pain; Rats; Rats, Sprague-Dawley; Receptors, Endothelin; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Viper Venoms

1994
Spinal nitric oxide synthesis inhibition blocks NMDA-induced thermal hyperalgesia and produces antinociception in the formalin test in rats.
    Pain, 1993, Volume: 54, Issue:3

    Topics: Analgesics; Animals; Arginine; Behavior, Animal; Formaldehyde; Hot Temperature; Injections, Spinal; Male; N-Methylaspartate; NG-Nitroarginine Methyl Ester; Nitric Oxide; omega-N-Methylarginine; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Spinal Cord

1993
Analysis of the mechanisms underlying the antinociceptive effect of the extracts of plants from the genus Phyllanthus.
    General pharmacology, 1995, Volume: 26, Issue:7

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analgesics; Animals; Arginine; Capsaicin; Clonidine; Male; Mice; Nitroarginine; Pain; Phenylephrine; Plant Extracts; Prazosin; Yohimbine

1995
L-NAME, an inhibitor of nitric oxide synthase, blocks the established allodynia induced by intrathecal administration of prostaglandin E2.
    Neuroscience letters, 1995, Dec-15, Volume: 201, Issue:3

    Topics: Animals; Arginine; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Injections, Spinal; Male; Mice; Mice, Inbred Strains; NG-Nitroarginine Methyl Ester; Pain; Spinal Cord

1995
Activation of the arginine-nitric oxide pathway in primary sensory neurons contributes to dipyrone-induced spinal and peripheral analgesia.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1996, Volume: 45, Issue:6

    Topics: Analysis of Variance; Anesthesia, Spinal; Animals; Anti-Infective Agents, Urinary; Anti-Inflammatory Agents, Non-Steroidal; Arginine; Dinoprostone; Dipyrone; Enzyme Inhibitors; Injections, Intraperitoneal; Injections, Intraventricular; Injections, Spinal; Male; Methylene Blue; Neurons, Afferent; Nitric Oxide; omega-N-Methylarginine; Pain; Rats; Rats, Wistar

1996
N(G)-nitro-L-arginine reverses L-arginine induced changes in morphine antinociception and distribution of morphine in brain regions and spinal cord of the mouse.
    Brain research, 1997, Feb-28, Volume: 749, Issue:2

    Topics: Analgesics, Opioid; Animals; Arginine; Brain; Male; Mice; Morphine; Nitroarginine; Pain; Spinal Cord; Tissue Distribution

1997
Rectal response of cardiac origin in the cat: involvement of nitric oxide and acetylcholine.
    European journal of pharmacology, 1997, May-01, Volume: 325, Issue:2-3

    Topics: Acetylcholine; Afferent Pathways; Animals; Arginine; Atropine; Blood Pressure; Cats; Coronary Vessels; Female; Ganglionic Blockers; Heart; Hexamethonium; Male; Muscle Contraction; Muscle Relaxation; Myocardial Ischemia; Neurotransmitter Agents; Nicotine; Nitric Oxide; Nitroarginine; Pain; Phentolamine; Propranolol; Rectum

1997
[Nitric oxide precursor--L-arginine--attenuates pain sensitivity during peroral administration in rats].
    Biulleten' eksperimental'noi biologii i meditsiny, 1997, Volume: 124, Issue:11

    Topics: Administration, Oral; Analgesics, Non-Narcotic; Animals; Arginine; Male; Nitric Oxide; Pain; Pain Measurement; Rats; Reaction Time

1997
[L-Arginine effects during central spinal pain syndrome].
    Biulleten' eksperimental'noi biologii i meditsiny, 1999, Volume: 127, Issue:2

    Topics: Animals; Arginine; Dose-Response Relationship, Drug; Endorphins; GABA Modulators; Nitric Oxide; Pain; Pain Measurement; Penicillin G; Rats; Spinal Cord; Syndrome

1999
Antinociceptive mechanism of Gosha-jinki-gan in streptozotocin-induced diabetic animals: role of nitric oxide in the periphery.
    Japanese journal of pharmacology, 1999, Volume: 79, Issue:3

    Topics: Analgesics; Animals; Arginine; Diabetes Mellitus, Experimental; Drugs, Chinese Herbal; Enzyme Inhibitors; Male; Methylene Blue; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nociceptors; Pain; Pain Threshold; Rats; Rats, Sprague-Dawley; Tail

1999
Inhibition of inducible nitric oxide synthase in persistent pain.
    Life sciences, 2000, Volume: 66, Issue:4

    Topics: Animals; Arginine; Carrageenan; Chronic Disease; Enzyme Inhibitors; Lysine; Male; Methylene Blue; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Pain; Rats; Rats, Wistar

2000
Amino acid release into the knee joint: key role in nociception and inflammation.
    Pain, 2000, Volume: 86, Issue:1-2

    Topics: Amino Acids; Anesthetics, Local; Animals; Arginine; Arthritis; Carrageenan; Chromatography, High Pressure Liquid; Citrulline; Glutamic Acid; Hindlimb; Injections, Intra-Articular; Joints; Kaolin; Lidocaine; Male; Pain; Rats; Rats, Sprague-Dawley; Synovial Fluid

2000
Role of guanylyl cyclase activation via thiamine in suppressing chemically-induced writhing in mouse.
    Arzneimittel-Forschung, 2000, Volume: 50, Issue:6

    Topics: Animals; Arginine; Benzoquinones; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Guanylate Cyclase; Male; Mice; Morphine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Pain; Pain Measurement; Thiamine

2000
Noxious stimulation increases glutamate and arginine in the periaqueductal gray matter in rats: a microdialysis study.
    Pain, 2000, Volume: 87, Issue:2

    Topics: Animals; Arginine; Fixatives; Formaldehyde; Glutamic Acid; Hindlimb; Male; Microdialysis; Pain; Pain Measurement; Periaqueductal Gray; Rats; Rats, Wistar; Stimulation, Chemical

2000
Arginine-rich peptides are blockers of VR-1 channels with analgesic activity.
    FEBS letters, 2000, Sep-15, Volume: 481, Issue:2

    Topics: Amino Acid Sequence; Analgesics; Animals; Arginine; Capsaicin; Dynorphins; Electric Conductivity; Eye; Inhibitory Concentration 50; Mice; Oocytes; Pain; Peptides; Receptors, Drug; TRPV Cation Channels; Xenopus laevis

2000
Opposing interplay between Neuropeptide FF and nitric oxide in antinociception and hypothermia.
    Peptides, 2000, Volume: 21, Issue:8

    Topics: Analgesics, Opioid; Animals; Area Under Curve; Arginine; Body Temperature; Dose-Response Relationship, Drug; Enzyme Inhibitors; Free Radical Scavengers; Hypothermia; Male; Mice; Morphine; Naloxone; Narcotic Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oligopeptides; Pain; Temperature

2000
Characterization of EP receptor subtypes responsible for prostaglandin E2-induced pain responses by use of EP1 and EP3 receptor knockout mice.
    British journal of pharmacology, 2001, Volume: 133, Issue:3

    Topics: Animals; Arginine; Behavior, Animal; Dinoprostone; Formaldehyde; Gene Deletion; Hyperalgesia; Mice; Mice, Knockout; Nitric Oxide; Nitroprusside; Nitroso Compounds; Pain; Pain Measurement; Reaction Time; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP3 Subtype

2001
Sildenafil-induced peripheral analgesia and activation of the nitric oxide-cyclic GMP pathway.
    Brain research, 2001, Aug-03, Volume: 909, Issue:1-2

    Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Acetic Acid; Analgesia; Animals; Arginine; Carrageenan; Central Nervous System; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Dose-Response Relationship, Drug; Female; Hyperalgesia; Male; Methylene Blue; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Nociceptors; Pain; Pain Measurement; Pain Threshold; Peripheral Nervous System; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Piperazines; Purines; Signal Transduction; Sildenafil Citrate; Sulfones

2001
Neuronal nitric oxide synthase (nNOS) mRNA is down-regulated, and constitutive NOS enzymatic activity decreased, in thoracic dorsal root ganglia and spinal cord of the rat by a substance P N-terminal metabolite.
    The European journal of neuroscience, 2001, Volume: 14, Issue:4

    Topics: Animals; Arginine; Capsaicin; Ganglia, Spinal; Lumbar Vertebrae; Male; Nerve Degeneration; Nerve Fibers; Neurons, Afferent; Nitric Oxide; Nitric Oxide Synthase; Nociceptors; Pain; Peptide Fragments; Rats; Rats, Sprague-Dawley; RNA, Messenger; Spinal Cord; Substance P; Thoracic Vertebrae

2001
Extracellular glutamate, aspartate and arginine increase in the ventral posterolateral thalamic nucleus during nociceptive stimulation.
    Brain research, 2001, Dec-27, Volume: 923, Issue:1-2

    Topics: Amino Acids; Animals; Arginine; Aspartic Acid; Electrophoresis, Capillary; Extracellular Space; Glutamic Acid; Male; Microdialysis; Nociceptors; Pain; Pain Measurement; Rats; Rats, Wistar; Synaptic Transmission; Ventral Thalamic Nuclei

2001
Production of endogenous nitric oxide and activation of soluble guanylate cyclase are required for N-methyl-D-aspartate-produced facilitation of the nociceptive tail-flick reflex.
    European journal of pharmacology, 1992, Apr-07, Volume: 214, Issue:1

    Topics: 2-Amino-5-phosphonovalerate; Animals; Arginine; Enzyme Activation; Guanylate Cyclase; Male; N-Methylaspartate; Nitric Oxide; Pain; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Reflex

1992
Increase of nitric oxide production by L-arginine potentiates i.c.v. administered beta-endorphin-induced antinociception in the mouse.
    European journal of pharmacology, 1992, Mar-03, Volume: 212, Issue:2-3

    Topics: Amino Acid Oxidoreductases; Animals; Arginine; beta-Endorphin; Drug Synergism; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Pain

1992
Synergistic anti-nociceptive effect of L-NG-nitro arginine methyl ester (L-NAME) and flurbiprofen in the mouse.
    British journal of pharmacology, 1992, Volume: 106, Issue:2

    Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arginine; Behavior, Animal; Blood Pressure; Drug Synergism; Flurbiprofen; Formaldehyde; Indomethacin; Male; Mice; Motor Activity; NG-Nitroarginine Methyl Ester; Pain

1992
Nitric oxide mediates the thermal hyperalgesia produced in a model of neuropathic pain in the rat.
    Neuroscience, 1992, Volume: 50, Issue:1

    Topics: Analysis of Variance; Animals; Arginine; Hot Temperature; Hyperalgesia; Male; Methylene Blue; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pain; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate

1992
Analgesic effect of L-arginine in patients with persistent pain.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 1991, Volume: 1, Issue:4

    Topics: Aged; Analgesics; Arginine; Chronic Disease; Cluster Headache; Dose-Response Relationship, Drug; Female; Humans; Infusions, Intravenous; Male; Middle Aged; Naloxone; Pain; Pain Measurement

1991
L-NG-nitro arginine methyl ester exhibits antinociceptive activity in the mouse.
    British journal of pharmacology, 1991, Volume: 102, Issue:1

    Topics: Administration, Oral; Analgesics; Animals; Arginine; Behavior, Animal; Blood Pressure; Brain Chemistry; Edema; Formaldehyde; Injections, Intraventricular; Male; Mice; Mice, Inbred Strains; Motor Activity; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pain

1991
Teniposide ameliorates bone cancer nociception in rats via the P2X7 receptor.
    Inflammopharmacology, 2018, Volume: 26, Issue:2

    Topics: Animals; Bone Neoplasms; Carcinoma; Cell Line, Tumor; Cytokines; Disease Models, Animal; Female; Hyperalgesia; Inflammation; Mammary Glands, Animal; Nociception; Pain; Pain Measurement; Pain Threshold; Rats; Rats, Wistar; Receptors, Purinergic P2X7; Teniposide

2018