amphotericin-b and Tuberculosis

amphotericin-b has been researched along with Tuberculosis* in 31 studies

Reviews

5 review(s) available for amphotericin-b and Tuberculosis

ArticleYear
Coccidioidomycosis masquerading as skeletal tuberculosis: an imported case and review of coccidioidomycosis in India.
    Tropical doctor, 2014, Volume: 44, Issue:1

    We describe a possible imported case of osteo-articular coccidioidomycosis in India. Culture of the computed tomography-guided aspirate revealed the growth of Coccidioides spp., which was identified as Coccidioides posadasii by sequencing of the internal transcribed spacer (ITS) region of rDNA. He was successfully treated with amphotericin B followed by itraconazole. All the previous published reports of coccidioidomycosis cases diagnosed in India are also reviewed in order to increase the awareness of this disease in non-endemic areas.

    Topics: Adult; Amphotericin B; Antifungal Agents; Biopsy, Fine-Needle; Coccidioides; Coccidioidomycosis; Diagnosis, Differential; Humans; India; Itraconazole; Male; Tomography, X-Ray Computed; Treatment Outcome; Tuberculosis

2014
Liposomes as potential carrier system for targeted delivery of polyene antibiotics.
    Recent patents on inflammation & allergy drug discovery, 2013, Volume: 7, Issue:3

    The development of new therapeutic modalities involves the use of drug carrier, such as liposomes, which can modify pharmacokinetic and bio-distribution of drug profile. Polyene antibiotics incorporation into liposomes improves its availability at the site, bio-distribution and therapeutic index mainly through the engulfment of liposomes by circulating monocytes/macrophages and transportation to the site of infection. Polyene antibiotics (AmB, SJA-95, HA-1-92) and other antibiotics (streptomycin, tobramycin, quinolones, anti-tubercular and anti-cancer drugs), liposomal preparations are described with possible advantages from therapeutic efficacy and toxicity point of view. The polyene macrolide antibiotics liposomal preparations proved to be more effective in the treatment of systemic mycosis. The AmB-cyclodextrin derivatives inclusion complex is a major breakthrough in liposomal preparation which can be converted into aqueous phase of liposome. Liposomal drug incorporated preparation has been one of the important areas of research for developing the existing polyene antibiotics into useful chemotherapeutic agents in clinical medicine. In recent past other antibiotics have also been incorporated into liposomes using wide variety of materials, phosphatidylethanolamine derivatives (pegylated liposomes, enzyme sensitive conjugates, fluidosomes of anti-cancer drugs and poly lactic/glycolic acid microspheres for anti-tuberculosis drugs). In addition, attempts were also made to extend the receptor mediated drug targeting and to review some relevant patents.

    Topics: Amphotericin B; Anti-Bacterial Agents; Dextrans; Drug Delivery Systems; Humans; Liposomes; Macrolides; Neoplasms; Phosphatidylethanolamines; Polyenes; Tuberculosis

2013
Liposome-based drug delivery to alveolar macrophages.
    Expert opinion on drug delivery, 2007, Volume: 4, Issue:2

    The recent development of liposomal formulations compatible with aerosol delivery has expanded the potential to utilise chemotherapeutic agents directly targeted to the lungs more effectively. These are agents that would otherwise not be used because of their low solubility or toxicity. Various properties of liposomal carriers, including size, surface charge, composition and the presence of ligands, alter their efficacy and specificity towards alveolar macrophages to a great extent. This editorial summarises the advances in liposome-based drug delivery to alveolar macrophages.

    Topics: Administration, Inhalation; Aerosols; Amphotericin B; Animals; Antifungal Agents; Antitubercular Agents; Bacterial Infections; Drug Carriers; Drug Delivery Systems; Liposomes; Lung Diseases, Fungal; Macrophages, Alveolar; Mice; Rats; Tuberculosis

2007
Tuftsin-bearing liposomes in treatment of macrophage-based infections.
    Advanced drug delivery reviews, 2000, Mar-30, Volume: 41, Issue:2

    The use of liposomes as drug carriers in treatment of various diseases has been explored extensively for more than 20 years. 'Conventional' liposomes, when administered in vivo by a variety of routes, rapidly accumulate in the mononuclear phagocyte system (MPS). The inherent tendency of the liposomes to concentrate in MPS can be exploited in enhancing the non-specific host defence against infections by entrapping in them the macrophage modulators, and as carriers of antibiotics in treatment of intracellular infections that reside in MPS. This must further be enhanced by grafting on the liposome surface the ligands, e.g. tuftsin, that not only binds specifically to the MPS cells but also enhances their natural killer activity. Keeping this in view, we designed and developed tuftsin-bearing liposomes as drug carriers for the treatment of macrophage-based infections and outline these studies in this overview.

    Topics: Amphotericin B; Animals; Drug Carriers; Drug Delivery Systems; Humans; Leishmaniasis; Liposomes; Macrophages; Malaria; Mycoses; Tuberculosis; Tuftsin

2000
Transfer factor in diseases of the central nervous system.
    Advances in neurology, 1974, Volume: 6

    Topics: Amphotericin B; Brain Diseases; Candidiasis; Coccidioidomycosis; Cryptococcosis; Herpes Zoster; Humans; Immunity, Cellular; Immunity, Maternally-Acquired; Leprosy; Lymphocyte Activation; Lymphokines; Male; Meningitis; Middle Aged; Subacute Sclerosing Panencephalitis; T-Lymphocytes; Tuberculosis; Wiskott-Aldrich Syndrome

1974

Other Studies

26 other study(ies) available for amphotericin-b and Tuberculosis

ArticleYear
The threat of persistent bacteria and fungi contamination in tuberculosis sputum cultures.
    African health sciences, 2021, Volume: 21, Issue:2

    Tuberculosis (TB) sputum culture contaminants make it difficult to obtain pure TB isolates.We aimed to study and identify persistent TB sputum culture contaminants post the standard laboratory pre-culture sample decontamination techniques.. This was a longitudinal study of TB sputum culture contamination for a cohort of TB patients on standard treatment at: baseline, during TB treatment and post TB treatment. Sputum samples were decontaminated with 1.5%NaOH and neutralized using 6.8 Phosphate buffer solution.Sputum was then inoculated into MGIT (mycobactrial growth indicator tube) supplemented with 0.8ml PANTA. A drop of each positive MGIT culture was sub cultured onto blood agar and incubated for 48 hours at 35 -37OC.Any growth was identified using growth characteristics and colony morphology.. From October 2017 through May 2019;we collected 8645 sputum samples of which 8624(99.8%) were eligible and inoculated into MGIT where 2444(28.3%)samples were TB culture positive and 255(10.4%)were positive for contaminants: 237 none-tuberculosis bacteria, 12 fungi and 6 mixed(none-tuberculous bacteria+fungi). There was no statistically significant difference between none tuberculosis bacteria and fungi in the treatment (OR=1.4,95%CI:0.26-7.47,p=0.690) and the post treatment TB phases(OR=2.02,95%CI:0.38-10.79,p=0.411)Vs baseline.. None-tuberculous bacteria and fungi dominate the plethora of TB sputum culture contamination and persist beyond the standard laboratory pre-culture decontamination algorithm.

    Topics: Amphotericin B; Anti-Bacterial Agents; Azlocillin; Bacteria; Bacteriological Techniques; Fungi; Humans; Longitudinal Studies; Mycobacterium tuberculosis; Nalidixic Acid; Polymyxin B; Sputum; Trimethoprim; Tuberculosis

2021
Amphotericin B Inhibits Mycobacterium tuberculosis Infection of Human Alveolar Type II Epithelial A549 Cells.
    Antimicrobial agents and chemotherapy, 2020, 09-21, Volume: 64, Issue:10

    Topics: A549 Cells; Alveolar Epithelial Cells; Amphotericin B; Epithelial Cells; Humans; Mycobacterium tuberculosis; Tuberculosis

2020
Novel 4-methoxynaphthalene-
    Future microbiology, 2019, Volume: 14

    Topics: Amphotericin B; Anti-Bacterial Agents; Antifungal Agents; Coinfection; Drug Combinations; Drug Discovery; Drug Synergism; Ethambutol; Humans; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Paracoccidioides; Paracoccidioidomycosis; Tuberculosis

2019
[Clinical comparative analysis for pulmonary histoplasmosis and progressive disseminated histoplasmosis].
    Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2016, Dec-28, Volume: 41, Issue:12

    To compare clinical features, diagnosis and therapeutic effect between pulmonary histoplasmosis and progressive disseminated histoplasmosis.
 Methods: A retrospective analysis for 12 cases of hospitalized patients with histoplasmosis, who was admitted in Xiangya Hospital, Central South University during the time from February 2009 to October 2015, was carried out. Four cases of pulmonary histoplasmosis and 8 cases of progressive disseminated histoplasmosis were included. The differences of clinical features, imaging tests, means for diagnosis and prognosis were analyzed between the two types of histoplasmosis.
 Results: The clinical manifestations of pulmonary histoplasmosis were mild, such as dry cough. However, the main clinical symptoms of progressive disseminated histoplasmosis were severe, including recurrence of high fever, superficial lymph node enlargement over the whole body, hepatosplenomegaly, accompanied by cough, abdominal pain, joint pain, skin changes, etc.Laboratory examination showed pancytopenia, abnormal liver function and abnormal coagulation function. One pulmonary case received the operation of left lower lung lobectomy, 3 cases of pulmonary histoplasmosis and 6 cases of progressive disseminated histoplasmosis patients were given deoxycholate amphotericin B, itraconazole, voriconazole or fluconazole for antifungal therapy. One disseminated case discharged from the hospital without treatment after diagnosis of histoplasmosis, and 1 disseminated case combined with severe pneumonia and active tuberculosis died ultimately.
 Conclusion: As a rare fungal infection, histoplasmosis is easily to be misdiagnosed. The diagnostic criteria depends on etiology through bone marrow smear and tissues biopsy. Liposomeal amphotericin B, deoxycholate amphotericin B and itraconazole are recommended to treat infection for histoplasma capsulatum.. 目的:比较肺型与进展播散型组织胞浆菌病的临床特点、诊断及预后差异。 方法:回顾性分析中南大学湘雅医院2009年2月至2015年10月期间收治的组织胞浆菌病住院患者12例,其中肺型4例,进展播散型8例。从临床表现、影像学、确诊途径及预后等方面分析两者之间的差异性。 结果:肺型组织胞浆菌病临床表现轻微,干咳多见。进展播散型患者全身症状明显,极易出现反复高热、全身浅表淋巴结肿大、肝脾肿大,可合并咳嗽、腹痛、关节痛、皮肤改变等。实验室检查示全血细胞减少、肝功能异常、凝血功能异常等。1例肺型患者给予了左下肺切除术,其余3例肺型及6例进展播散型患者分别给予两性霉素B脱氧胆酸盐、伊曲康唑、伏立康唑或氟康唑抗真菌感染治疗,好转出院,1例播散型确诊后暂未治疗即出院,1例播散型因合并重症肺炎及活动性肺结核治疗无效死亡。结论:组织胞浆菌病临床少见,极易漏诊或误诊,依靠骨髓涂片、病理组织切片特殊染色明确病原学是目前确诊的主要依据,推荐两性霉素B脂质体、两性霉素B脱氧胆酸盐及伊曲康唑抗感染治疗。.

    Topics: Abdominal Pain; Amphotericin B; Antifungal Agents; Biopsy; Cough; Death; Deoxycholic Acid; Diagnostic Errors; Drug Combinations; Fever; Hepatomegaly; Histoplasma; Histoplasmosis; Humans; Invasive Fungal Infections; Itraconazole; Lung; Lung Diseases, Fungal; Pneumonia; Recurrence; Retrospective Studies; Splenomegaly; Treatment Outcome; Tuberculosis

2016
Penicilliosis and AIDS in Haiphong, Vietnam: evolution and predictive factors of death.
    Medecine et maladies infectieuses, 2014, Volume: 44, Issue:11-12

    The study objective was to assess the lethality rates and the predictive factors for death in AIDS patients infected by Penicillium marneffei (Pm) in Hai Phong, Vietnam.. A retrospective cohort study was conducted by reviewing 103 medicals records of confirmed cases from June 2006 to August 2009.. Penicilliosis-related mortality was very high (33%). The majors risk factors of death were: (i) patient lacking complete treatment, a regimen with both of secondary prophylaxis by itraconazole and HAART (OR=52.2, P<0.001); (ii) patients having received only secondary prophylaxis (OR=21.2, P<0.001); (iii) patients coinfected by hepatitis C (OR=2.3, P=0.02) and tuberculosis (OR=1.97, P=0.04). Penicilliosis occurred in 28 cases after initiation of ART, probably caused by IRIS, with the same signs and symptoms as "common" penicilliosis. However, the diagnosis of IRIS was ruled out because the viral load could not be assessed.. Penicilliosis is very frequent in the North of Vietnam. A good compliance to a complete treatment with healing antifungal (Amphotericin B) then secondary prophylaxis (Itraconazole) associate with ART, prolongs survival, prevents relapse, and also allows discontinuing a secondary prophylaxis in a half of the cases.

    Topics: Adult; AIDS-Related Opportunistic Infections; Amphotericin B; Antifungal Agents; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Female; Follow-Up Studies; Hepatitis B; Hepatitis C; Humans; Immune Reconstitution Inflammatory Syndrome; Incidence; Itraconazole; Kaplan-Meier Estimate; Male; Mycoses; Penicillium; Recurrence; Retrospective Studies; Risk Factors; Tuberculosis; Vietnam

2014
Tuberculosis and histoplasmosis co-infection in AIDS patients.
    The American journal of tropical medicine and hygiene, 2012, Volume: 87, Issue:6

    Abstract. Coinfection with tuberculosis in some countries occurs in 8-15% of human immunodeficiency virus (HIV) -infected patients who have histoplasmosis. This coinfection interferes with prompt diagnosis, and treatment is difficult because of drug interactions. We retrospectively reviewed the cases of 14 HIV-infected patients who had concomitant tuberculosis and histoplasmosis. The most frequent clinical manifestations were weight loss (85.7%), asthenia (78.5%), and fever (64.2%). The diagnosis of histoplasmosis was made primarily by histopathology (71.4%), and the diagnosis of tuberculosis was made by means of direct microscopic examination (71.4%). Death occurred in two patients, and relapse of both infections occurred in one patient. Moxifloxacin was substituted for rifampicin in six patients, with good outcomes noted for both infections. The clinical presentation does not readily identify acquired immunodeficiency syndrome (AIDS) patients who have tuberculosis and histoplasmosis. The use of a fluoroquinolone as an alternative agent in place of rifampicin for tuberculosis allows effective therapy with itraconazole for histoplasmosis.

    Topics: Acquired Immunodeficiency Syndrome; Adult; Amphotericin B; Antifungal Agents; Coinfection; Deoxycholic Acid; Drug Combinations; Female; Histoplasmosis; Humans; Itraconazole; Male; Middle Aged; Retrospective Studies; Risk Factors; Tuberculosis

2012
Anti-tubercular agents. Part 5: synthesis and biological evaluation of benzothiadiazine 1,1-dioxide based congeners.
    European journal of medicinal chemistry, 2010, Volume: 45, Issue:10

    In an effort to discover new and effective chemotherapeutic agents from this laboratory for the treatment of tuberculosis, here in we describe the synthesis and biological evaluation of a series of novel benzothiadiazine 1,1-dioxide (BTD) based congeners by using rifampicin, streptomycin; ciprofloxacin and amphotericin as positive controls. Further, to understand structural requirements for exploring the structure activity relationship of BTDs, cytotoxicity and in vivo study of recently reported potent molecule 4 (MIC = 1 microg/mL) is also discussed.

    Topics: Animals; Antitubercular Agents; Bacteria; Benzothiadiazines; Cell Line; Cell Survival; Female; Fungi; Humans; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Tuberculosis

2010
Tuberculous and cryptococcal meningitis in a setting with high TB and low HIV prevalence.
    Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, 2009, Volume: 19, Issue:8

    To compare the differences in presentation and outcome of patients with tuberculous meningitis (TBM) and cryptococcal meningitis (CCM).. Case series.. The Aga Khan University Hospital, Karachi, from December 1995 to December 2005.. Patients with a confirmed diagnosis of TBM or CCM were included in this study. The signs and symptoms, laboratory findings and other variables of patients were entered and analyzed by Statistical Package for Social Sciences (SPSS) Software version 14.. We compared 16 patients of TBM with 11 of CCM. None of the patients with TBM were Human Immunodeficiency Virus (HIV) positive while 4 patients with CCM had HIV. The common initial signs and symptoms in patients with TBM were fever, altered mental status and headache; and in patients with CCM were fever, headache and cough. The mean CSF glucose level decreased according to the Medical Research Council (MRC) stage in TBM. The mean CSF RBCs, WBCs, glucose and protein in TBM were 2010/mm3, 228/mm3, 52.32 mg/dL and 289.48 mg/dl respectively and in CCM were 178.54/mm3, 529.54/mm3, 32.63 mg/dL and 432.18 mg/dL respectively.. TBM and CCM should be suspected in all cases that present with symptoms of chronic meningitis. Patients with TBM are more likely to have altered mental status and higher CSF RBCs; those with CCM are more likely to have headache, cough and higher CSF WBCs.

    Topics: Amphotericin B; Anti-Bacterial Agents; Biomarkers; Cerebrospinal Fluid; Diuretics, Osmotic; Female; HIV Infections; Humans; Male; Mannitol; Meningitis, Cryptococcal; Middle Aged; Pakistan; Prevalence; Treatment Outcome; Tuberculosis; Tuberculosis, Meningeal

2009
Unresponsiveness to AmBisome in some Sudanese patients with kala-azar.
    Transactions of the Royal Society of Tropical Medicine and Hygiene, 2007, Volume: 101, Issue:1

    In Sudan, two treatments are currently registered for visceral leishmaniasis: sodium stibogluconate (SSG) as first line and liposomal amphotericin B (AmBisome) as second line. We present 64 patients (52 relapse cases to SSG, 12 new but complicated cases) treated with AmBisome in eastern Sudan. AmBisome was administered at 2.5-8.2mg/kg (15-49mg/kg in total) per dose six times (days 1, 2, 3, 5, 10, 15) as an intravenous infusion. We measured outcome according to clinical response and parasitological clearance (lymph node aspiration). Patient outcomes fell into three groups: group 1, clinical responders (cured) with a negative test of cure (n=35); group 2, clinical responders with a positive test of cure (n=19); group 3, clinical non-responders (failures) with a positive test of cure (n=10). Of the 10 failures, six were already relapse cases. All of group 3, and 15 from group 2, were also treated with additional SSG (20mg/kg intramuscularly daily for 30-50 d) with resulting clinical and parasitological improvement. Parasite persistence and clinical failure were associated with a higher parasite density on admission (P<0.002) and underlying immunosuppressive disease: tuberculosis (three cases) or HIV (two cases). Because AmBisome monotherapy may fail in Sudan, a combination of AmBisome and SSG is recommended for relapse cases.

    Topics: Adolescent; Adult; Amphotericin B; Antiprotozoal Agents; Child; Child, Preschool; Dose-Response Relationship, Drug; Female; HIV Infections; Humans; Infant; Infusions, Intravenous; Leishmaniasis, Visceral; Male; Risk Factors; Treatment Failure; Tuberculosis

2007
Disseminated osteoarticular sporotrichosis: treatment in a patient with acquired immunodeficiency syndrome.
    Southern medical journal, 2000, Volume: 93, Issue:8

    We report a case of multiple skin lesions, lymphadenopathy, and osteoarticular sporotrichosis in a man infected with human immunodeficiency virus (HIV). He subsequently died of tuberculosis after successful treatment for osteoarticular sporotrichosis with amphotericin B. We describe the unusual histopathology in disseminated sporotrichosis with acquired immunodeficiency syndrome (AIDS) and compare it with that seen in patients without AIDS. Although the optimal treatment of osteoarticular sporotrichosis in patients with AIDS is unknown, use of amphotericin B in our patient appeared successful. Culture and histologic stains of all tissues taken at autopsy were negative for sporotrichosis. Recent studies of similar cases have shown initial treatment with amphotericin B followed by long-term maintenance with itraconazole to be beneficial.

    Topics: Adult; AIDS-Related Opportunistic Infections; Amphotericin B; Antifungal Agents; Biopsy; Bone Diseases, Infectious; Diabetes Complications; Fatal Outcome; Humans; Joint Diseases; Lymphatic Diseases; Male; Sporotrichosis; Substance Abuse, Intravenous; Synovial Fluid; Treatment Outcome; Tuberculosis

2000
Cryptococcosis of thoracic vertebra simulating tuberculosis: diagnosis by fine-needle aspiration biopsy cytology--a case report.
    Diagnostic cytopathology, 1999, Volume: 20, Issue:6

    A rare case of cryptococcosis of sixth thoracic vertebra (T6) along with pulmonary involvement in an old diabetic patient is presented. The infection resulted in lytic lesion of T6 vertebra and girdle pain. A computerized tomographic (CT) guided fine-needle aspiration biopsy (FNAB) cytology was performed, which showed encapsulated fungal spores of Cryptococcus neoformans with granulomatous reaction, later confirmed by fungal culture.

    Topics: Aged; Amphotericin B; Antifungal Agents; Antitubercular Agents; Biopsy, Needle; Cryptococcosis; Diagnosis, Differential; Humans; Spinal Diseases; Thoracic Vertebrae; Tomography, X-Ray Computed; Tuberculosis

1999
Tuberculosis-like illness in a young man from Thailand.
    AIDS clinical care, 1996, Volume: 8, Issue:12

    A case study is presented of a mid-20's, HIV-infected male visitor from Thailand who became increasingly ill with tuberculosis-like symptoms. The question addressed is whether the patient should be treated for miliary tuberculosis or for disseminated Mycobacterium avium complex (MAC) infection pending further evaluation. It is argued that due to the frequency with which Penicillium marneffei infection occurs in Thai AIDS patients and the similarity of the symptoms to MAC infection, such treatment is not warranted. Following isolation of P. marneffei, the patient was treated with high dose amphotericin B and responded well, defervescing within a week.

    Topics: Adult; Amphotericin B; Antifungal Agents; Diagnosis, Differential; HIV Infections; Humans; Male; Mycoses; Penicillium; Thailand; Tuberculosis; United States

1996
Drugs for AIDS and associated infections.
    The Medical letter on drugs and therapeutics, 1995, Oct-13, Volume: 37, Issue:959

    Topics: Acquired Immunodeficiency Syndrome; AIDS-Related Opportunistic Infections; Amphotericin B; Antifungal Agents; Antiprotozoal Agents; Antiviral Agents; Atovaquone; Candidiasis, Oral; Clindamycin; Clotrimazole; Cryptosporidiosis; Cytomegalovirus Infections; Dapsone; Didanosine; Drug Combinations; Drug Therapy, Combination; Fluconazole; Flucytosine; Folic Acid Antagonists; Foscarnet; Glucuronates; Herpes Simplex; Herpes Zoster; Humans; Isoniazid; Itraconazole; Ketoconazole; Lamivudine; Mycobacterium avium-intracellulare Infection; Naphthoquinones; Nystatin; Pentamidine; Pneumocystis Infections; Pneumonia, Pneumocystis; Prednisone; Primaquine; Reverse Transcriptase Inhibitors; Stavudine; Syphilis; Toxoplasmosis; Trimetrexate; Tuberculosis; Zalcitabine; Zidovudine

1995
Opportunistic infections studies update.
    NIAID AIDS agenda, 1995,Spring

    Studies being conducted on opportunistic infections among people with HIV are presented in list form. The list includes new studies, those still in development, and those slated to begin in 1995. Areas of interest include candidiasis, cryptosporidiosis/microsporidiosis, cytomegalovirus (CMV), Mycobacterium avium complex (MAC) infection, Pneumocystis carinii pneumonia (PCP), toxoplasmosis, and tuberculosis (TB). Enrollment information can be obtained by calling 1-(800)-TRIALS-A (TDD 1- 800-448-0440).

    Topics: AIDS-Related Opportunistic Infections; Amphotericin B; Antitubercular Agents; Atovaquone; Candidiasis; Clinical Trials as Topic; Cryptosporidiosis; Cytomegalovirus; Cytomegalovirus Infections; Ganciclovir; Humans; Immunotherapy; Mycobacterium avium-intracellulare Infection; Naphthoquinones; Paromomycin; Pneumonia, Pneumocystis; Pyrimethamine; Toxoplasmosis; Tuberculosis

1995
[Treatment and prevention of main infections associated with HIV].
    Medicina clinica, 1994, Dec-10, Volume: 103, Issue:20

    Topics: Adrenal Cortex Hormones; Amphotericin B; Controlled Clinical Trials as Topic; Cryptococcosis; Fluconazole; HIV Infections; Humans; Isoniazid; Pneumonia, Pneumocystis; Prospective Studies; Tuberculosis

1994
Histoplasmosis in the acquired immune deficiency syndrome.
    The American journal of medicine, 1985, Volume: 78, Issue:2

    This report describes the experience with disseminated histoplasmosis in seven of 15 patients with the acquired immune deficiency syndrome (AIDS) diagnosed in Indianapolis since 1981. Three were homosexual, two were intravenous drug addicts, one was the spouse of another patient with AIDS and disseminated histoplasmosis, and the seventh was a hemophiliac. Six had associated infections: candidiasis in three, Pneumocystis carinii pneumonia, recurrent mucocutaneous herpes simplex infection, and disseminated Mycobacterium avium infection in two each, and disseminated infection with an unidentified mycobacterium in one. Clinical diseases suggested sepsis in four. Histoplasma fungemia occurred in five, but the diagnosis was established first by visualization of organisms in blood or bone marrow in three. Results of Histoplasma serologic tests were positive in each. Three died before receiving 50 mg of amphotericin B, three had prompt improvement with amphotericin B, and one was treated with ketoconazole to prevent dissemination. However, two of the three patients treated with amphotericin B had relapses after a 35 mg/kg course, and the third died within a month following therapy. Disseminated histoplasmosis is a major opportunistic infection in patients with AIDS from endemic areas. AIDS should be strongly considered in otherwise healthy persons with disseminated histoplasmosis, especially if risk factors for AIDS are present. Amphotericin B is not curative in these patients.

    Topics: Acquired Immunodeficiency Syndrome; Adult; Amphotericin B; Candidiasis; Female; Herpes Simplex; Histoplasmosis; Homosexuality; Humans; Ketoconazole; Male; Mycobacterium avium; Mycobacterium Infections; Pneumonia, Pneumocystis; Tuberculosis

1985
Penicilliosis marneffei in Thailand: report of five human cases.
    The American journal of tropical medicine and hygiene, 1984, Volume: 33, Issue:4

    The first two cases of Penicillium marneffei infection in humans were reported in 1959 and 1973. There had been no additional clinical reports of penicilliosis marneffei, until the five new cases of human infection described in this paper, the first from Thailand. The patients, three of whom died, came from various parts of the country. Their common clinical manifestations were fever and generalized lymphadenopathy, with multiple soft tissue, bone, joint and pulmonary involvement. Pericarditis with effusion was also seen. The diagnosis was established by isolating and identifying a dimorphic Penicillium species that produced a soluble red pigment in its mycelial form. The histopathologic features of the lymph nodes and bone marrow were similar to those of histoplasmosis capsulati. However, the yeast-like tissue form of P. marneffei divides by fission; that of Histoplasma capsulatum by budding. Treatment with amphotericin B was effective when this antifungal antibiotic was administered early in the course of the disease.

    Topics: Adult; Amphotericin B; Child; Female; Humans; Lupus Erythematosus, Systemic; Lymphoproliferative Disorders; Male; Middle Aged; Mycoses; Penicillium; Pregnancy; Pregnancy Complications, Infectious; Thailand; Tuberculosis

1984
Unusual fungal infections following jejunoileal bypass surgery.
    Archives of internal medicine, 1980, Volume: 140, Issue:5

    Deep-seated fungal infections with unusual clinical courses developed in three previously healthy patients following jejunoleal bypass surgery. Pulmonary blastomycosis disseminated and then relapsed despite repeated courses of amphotericin B in a 40-year-old man; chronic progressive pulmonary histoplasmosis developed in a 38-year-old nonsmoking man; and histoplasmosis of mediastinal nodes became symptomatic in a 32-year-old man. Cell-mediated immunity was evaluated in two patients; no defects were found. However, male patients were found to be at a significantly higher risk of infection than female patients (3/32 vs 0/101; P less than .02). A significantly higher percentage of prebypass weight was lost by the infected men than the uninfected men (P less than .05). Accelerated weight loss clearly preceded the onset of the infection in two of the patients. Jejunoileal bypass surgery should be regarded as a risk factor for serious fungal infection, especially in men with accelerated weight loss.

    Topics: Adult; Amphotericin B; Blastomycosis; Female; Histoplasmosis; Humans; Ileum; Immunity, Cellular; Jejunum; Lung Diseases, Fungal; Male; Mediastinal Diseases; Mycoses; Obesity; Postoperative Complications; Risk; Sex Factors; Tuberculosis

1980
PULMONARY HISTOPLASMOSIS.
    Journal of chronic diseases, 1964, Volume: 17

    Topics: Amphotericin B; Black People; Complement Fixation Tests; Diagnosis, Differential; Histoplasmosis; Humans; Infant; Lung Diseases; Lung Diseases, Fungal; Pathology; Radiography, Thoracic; Rest; Surgical Procedures, Operative; Tennessee; Tuberculosis; Tuberculosis, Pulmonary

1964
HISTOPLASMOSIS IN INFANTS AND CHILDREN.
    GP, 1964, Volume: 30

    Topics: Amphotericin B; Child; Drug Therapy; Histoplasmosis; Humans; Infant; Lung Diseases; Lung Diseases, Fungal; Radiography, Thoracic; Sulfonamides; Tuberculosis; Tuberculosis, Pulmonary

1964
COCCIDIOIDOMYCOSIS. LONG-TERM TREATMENT WITH AMPHOTERICIN B OF DISSEMINATED DISEASE IN A THREE-MONTH-OLD BABY.
    American journal of diseases of children (1960), 1964, Volume: 108

    Topics: Amphotericin B; Coccidioidomycosis; Diagnosis, Differential; Drug Therapy; Humans; Infant; Lung Diseases; Lung Diseases, Fungal; Pathology; Prognosis; Radiography, Thoracic; Serologic Tests; Skin Tests; Toxicology; Tuberculosis; Tuberculosis, Miliary

1964
Genitourinary blastomycosis.
    Canadian Medical Association journal, 1963, Jul-13, Volume: 89

    Topics: Amphotericin B; Blastomycosis; Humans; Tuberculosis; Tuberculosis, Urogenital; Urinary Tract Infections; Urogenital System

1963
CRYPTOCOCCAL MENINGO-ENCEPHALITIS.
    Journal of the Royal Army Medical Corps, 1963, Volume: 109

    Topics: Amphotericin B; Cryptococcosis; Encephalitis; Humans; Isoniazid; Meningoencephalitis; Streptomycin; Tetracycline; Tuberculosis; Tuberculosis, Pulmonary

1963
TREATMENT OF MENINGITIS.
    JAMA, 1963, Sep-28, Volume: 185

    Topics: Amphotericin B; Anti-Bacterial Agents; Cerebrospinal Fluid; Chloramphenicol; Humans; Influenza, Human; Leptospirosis; Meningitis; Meningitis, Pneumococcal; Meningitis, Viral; Mycoses; Neurosyphilis; Penicillins; Pseudomonas Infections; Staphylococcal Infections; Streptococcus pneumoniae; Streptomycin; Tuberculosis; Tuberculosis, Meningeal

1963
[LUNG ASPERGILLOSIS].
    Annales medicinae internae Fenniae, 1963, Volume: 52

    Topics: Amphotericin B; Aspergillosis; Iodides; Lung Diseases, Fungal; Pathology; Pulmonary Aspergillosis; Radiography, Thoracic; Surgical Procedures, Operative; Tuberculosis; Tuberculosis, Pulmonary

1963
[INTRACAVITARY MEGAMYCETOMA (ASPERGILLOMA). REPORT ON 2 CASES].
    La Semana medica, 1963, Aug-19, Volume: 123

    Topics: Amphotericin B; Aspergillosis; Diagnosis, Differential; Humans; Lung Diseases; Lung Diseases, Fungal; Microbiology; Nystatin; Radiography, Thoracic; Tuberculosis; Tuberculosis, Pulmonary

1963
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