amphotericin-b and Stomatitis--Denture

amphotericin-b has been researched along with Stomatitis--Denture* in 17 studies

Reviews

1 review(s) available for amphotericin-b and Stomatitis--Denture

ArticleYear
[Denture stomatitis].
    Schweizer Monatsschrift fur Zahnmedizin = Revue mensuelle suisse d'odonto-stomatologie = Rivista mensile svizzera di odontologia e stomatologia, 1991, Volume: 101, Issue:2

    Topics: Amphotericin B; Candidiasis, Oral; Denture, Complete; Denture, Partial; Disease Susceptibility; Humans; Miconazole; Nystatin; Stomatitis, Denture

1991

Trials

6 trial(s) available for amphotericin-b and Stomatitis--Denture

ArticleYear
Comparative trial of fluconazole and amphotericin in the treatment of denture stomatitis.
    Oral surgery, oral medicine, and oral pathology, 1993, Volume: 76, Issue:1

    The efficacy of fluconazole and amphotericin in the management of denture stomatitis was investigated in a comparative trial. Patients were assessed clinically, hematologically, and mycologically at the time of entry into the study and at 1, 4, and 12 weeks thereafter. A total of 29 patients were selected at random to receive 50 mg of fluconazole daily for 14 days; 30 patients were selected to receive amphotericin lozenges and cream for 28 days. Clinical response rates were similar in both treatment groups throughout the study. The best mycologic response was noted after 1 week whereas the best clinical response was observed after 4 weeks. Clinical evidence of relapse and recurrence at 12 weeks was a common finding irrespective of treatment. Side effects were uncommon in both groups.

    Topics: Adult; Aged; Aged, 80 and over; Amphotericin B; Candidiasis, Oral; Erythema; Female; Fluconazole; Humans; Male; Middle Aged; Random Allocation; Stomatitis, Denture

1993
The treatment of denture-induced stomatitis. Evaluation of two agents.
    British dental journal, 1981, Dec-15, Volume: 151, Issue:12

    Topics: Amphotericin B; Antifungal Agents; Candidiasis, Oral; Clinical Trials as Topic; Dental Plaque; Denture Cleansers; Humans; Placebos; Stomatitis; Stomatitis, Denture

1981
Antimycotic denture adhesive in treatment of denture stomatitis.
    The Journal of prosthetic dentistry, 1978, Volume: 40, Issue:6

    The mycologic findings of Candida albicans or culturally similar yeasts in 70% of the subject sample is consistent with those of other researchers. It is, however, only one of several etiologic factors requiring concomitant study to obtain meaningful results. Use of an antimycotic denture adhesive did not prove to be effective in the treatment of denture stomatitis. Although in the trial it appeared that marginally better results were obtained with the amphotericin medicated adhesive, this could not be substantiated statistically. On retrospective testing in the laboratory, both medicated and placebo materials were found to have an inhibiting effect on the growth of C. albicans. However, it was considered that the beneficial effects noted were probably due to the adhesive and lubricant effects of the test materials in reducing denture trauma in function.

    Topics: Adhesives; Amphotericin B; Candida albicans; Clinical Trials as Topic; Denture Retention; Denture, Complete; Double-Blind Method; Female; Humans; Male; Mouth Mucosa; Photography; Placebos; Powders; Stomatitis; Stomatitis, Denture

1978
Denture stomatitis. Effects of chlorhexidine and amphotericin B on the mycotic flora.
    Acta odontologica Scandinavica, 1975, Volume: 33, Issue:1

    In 100 patients with denture stomatitis cultures and direct smears were used to evaluate 5 treatments, including sucking of chlorhexidine, amphotericin B or placebo tablets combined with denture soaking in 0.2% chlorhexidine or water. After 14 days of treatment the amphotericin B lozenges had brought about a significant reduction in the quantity of fungus on the oral mucosa, whereas they barely affected the large amount present on the fitting surface of the upper denture. Denture immersion in chlorhexidine significantly reduced the number of organisms both on the mucous membrane and on the denture. It therefore seems at least as important to treat the denture as the patient in denture stomatitis. Fourteen days after withdrawal of the drugs the mycotic flora was largely re-established.

    Topics: Amphotericin B; Biguanides; Chlorhexidine; Clinical Trials as Topic; Denture, Complete, Upper; Drug Therapy, Combination; Female; Humans; Male; Mycoses; Stomatitis; Stomatitis, Denture

1975
Denture stomatitis. The clinical effects of chlorhexidine and amphotericin B.
    Acta odontologica Scandinavica, 1975, Volume: 33, Issue:1

    The clinical effects of an antibacterial substance with antifungal activity (chlorhexidine) and specific antimycotic (amphotericin B) in denture stomatitis were studied in 100 patients. Five 14-day regimens of chlorhexidine, amphotericin B or placebo lozenges combined with denture immersion in 0.2% chlorhexidine or water were tested. The efficiency of amphotericin B and chlorhexidine was comparable. This indicates that chlorhexidine has a considerable antifungal effect in the oral cavity and, further, that fungi are the responsible micro-organism in denture stomatitis rather than bacteria. Chlorhexidine frequently discloured the dentures. A high incidence of local and general predisposing factors to denture stomatitis, as well as of relapse 14 days after treatment, was observed.

    Topics: Amphotericin B; Biguanides; Chlorhexidine; Clinical Trials as Topic; Drug Therapy, Combination; Erythema; Humans; Maxillary Diseases; Mycoses; Stomatitis; Stomatitis, Denture

1975
Nystatin and amphotericin B in the treatment of denture-related candidiasis.
    Oral surgery, oral medicine, and oral pathology, 1975, Volume: 40, Issue:1

    A double-blind trial of nystatin, amphotericin B, and a placebo was carried out in fifty-two cases of denture-related candidiasis and/or angular cheilitis. The drugs effected a significant clinical cure, but recurrence of the signs was common after withdrawal of the drugs. Concurrent bacteriologic examination showed few cures and continued presence of Candida albicans during the trial. A specimen from a red palate was examined histologically.

    Topics: Amphotericin B; Blood Vessels; Candida albicans; Candidiasis, Oral; Cheilitis; Denture, Complete, Upper; Epithelium; Humans; Nystatin; Palate; Placebos; Stomatitis; Stomatitis, Denture

1975

Other Studies

10 other study(ies) available for amphotericin-b and Stomatitis--Denture

ArticleYear
Susceptibility profile of a Brazilian yeast stock collection of Candida species isolated from subjects with Candida-associated denture stomatitis with or without diabetes.
    Oral surgery, oral medicine, oral pathology and oral radiology, 2013, Volume: 116, Issue:5

    This study investigated the susceptibility of 198 clinical isolates of Candida species against caspofungin, amphotericin B, itraconazole, and fluconazole.. Suspensions of the microorganisms were spread on Roswell Park Memorial Institute (RPMI) agar plates. Etest strips were placed on the plates, and the minimal inhibitory concentration (MIC) was read after incubation (48 h at 37 °C). Data were analyzed by a factorial analysis of variance and a 2 × 2 post hoc test (α = .05).. C glabrata showed the highest MIC values (P < .001) against caspofungin, itraconazole, and fluconazole. For amphotericin B, the MIC values of C tropicalis and C glabrata (P = .0521) were higher than those of C albicans (P < .001). Itraconazole was the least effective antifungal; 93.3% of the C glabrata isolates, 3.3% of the C albicans, and 1.3% of the C tropicalis were resistant. All microorganisms were susceptible to caspofungin and amphotericin B.. Caspofungin and amphotericin B should be recommended as an effective alternative for the management of oral Candida infections when treatment with topical or other systemic drugs has definitely failed.

    Topics: Amphotericin B; Antifungal Agents; Brazil; Candida; Candidiasis, Oral; Caspofungin; Diabetes Mellitus; Drug Resistance, Fungal; Echinocandins; Fluconazole; Humans; Itraconazole; Lipopeptides; Microbial Sensitivity Tests; Stomatitis, Denture

2013
Denture stomatitis: a role for Candida biofilms.
    Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics, 2004, Volume: 98, Issue:1

    To assess the contribution of Candida biofilms to the etiology of denture stomatitis.. Samples of denture acrylic were retrieved from patients with denture stomatitis and subjected to scanning electron microscopy (SEM) analysis. Oral swab and swish samples were taken from the same group of patients and representative C albicans isolates recovered were used to investigate the kinetics of biofilm development in vitro.. Candida biofilms could be visualized by SEM directly from denture samples from patients with denture stomatitis. These biofilms showed a propensity to adhere along cracks and imperfections of the denture acrylic. C albicans clinical isolates were able to form biofilms in vitro, although differences in the extent of biofilm formation were observed for different isolates recovered from the same patient. Susceptibility testing indicated that the resulting biofilms showed increased resistance to antifungal treatment. Presence of serum and saliva conditioning films increased the initial adherence of selected isolates but had little effect in overall biofilm formation.. Candida biofilms play a role in denture stomatitis.

    Topics: Acrylic Resins; Amphotericin B; Antifungal Agents; Biofilms; Candida albicans; Cell Adhesion; Denture, Complete, Upper; Fluconazole; Humans; Microbial Sensitivity Tests; Stomatitis, Denture

2004
Oral candidosis in patients with removable dentures.
    Mycoses, 2003, Volume: 46, Issue:5-6

    The prevalence of Candida species with and without denture-related stomatitis were evaluated in 167 Jordanian patients. The study revealed that 47 (28%) of the patients with denture-related stomatitis were colonized with Candida species (clinical group). Candida albicans was responsible for most cases of denture-related stomatitis (72%), and it was the only species capable of secreting aspartic proteinases. The study also indicated that candidal colonization was not influenced by predisposing haematological deficiencies, as both the clinical and control patient groups showed comparable haematological parameters and the differences were not significant (P > 0.05). All Candida species isolates were 100% susceptible to amphotericin B, while these isolates were less susceptible (25-75%) to fluconazole.

    Topics: Aged; Amphotericin B; Antifungal Agents; Aspartic Acid Endopeptidases; Candida; Candidiasis, Oral; Female; Fluconazole; Humans; Jordan; Male; Middle Aged; Prevalence; Stomatitis, Denture

2003
Antifungal resistance of candidal biofilms formed on denture acrylic in vitro.
    Journal of dental research, 2001, Volume: 80, Issue:3

    Denture biofilms represent a protective reservoir for oral microbes. The study of the biology of Candida in these biofilms requires a reliable model. A reproducible model of C. albicans denture biofilm was developed and used to determine the susceptibility of two clinically relevant C. albicans isolates against 4 antifungals. C. albicans, growing as a biofilm, exhibited resistance to amphotericin B, nystatin, chlorhexidine, and fluconazole, with 50% reduction in metabolic activity (50% RMA) at concentrations of 8, 16, 128, and > 64 microg/mL, respectively. In contrast, planktonically cultured C. albicans were susceptible (50% RMA for the same antifungals was obtained at 0.25, 1.0, 4.0, and 0.5 microg/mL, respectively). In conclusion, results obtained by means of our biofilm model show that biofilm-associated C. albicans cells, compared with cells grown in planktonic form, are resistant to antifungals used to treat denture stomatitis.

    Topics: Acrylic Resins; Amphotericin B; Anti-Infective Agents, Local; Antifungal Agents; Biofilms; Candida albicans; Candidiasis, Oral; Chlorhexidine; Colony Count, Microbial; Denture Bases; Dose-Response Relationship, Drug; Drug Resistance, Microbial; Fluconazole; Galactose; Glucose; Humans; Indicators and Reagents; Nystatin; Polymethyl Methacrylate; Saliva; Statistics as Topic; Stomatitis, Denture; Sucrose; Tetrazolium Salts; Time Factors

2001
Candida albicans strain differentiation in complete denture wearers.
    The new microbiologica, 2000, Volume: 23, Issue:3

    Strain differentiation of 66 clinical isolates of Candida albicans obtained from healthy dentate and complete denture wearers was performed. Resistogram method based on differences in the resistance of C. albicans isolates to sodium selenite, boric acid, cetrimide, sodium periodate and silver nitrate was used for strain differentiation. Of the 32 potential strains that can be distinguished, 14 different resistogram strains of C. albicans were found among the 66 isolates tested. Strain-C--was the most predominant (24.3% of total isolates), while strain A-CDE was the least predominant (1.5%). The results showed no particular association of certain strains with Candida infections in complete denture wearers. Sensitivity to antifungal agents showed that isolates from different strains were most sensitive to amphotericin B and nystatin and least sensitive to miconazole.

    Topics: Amphotericin B; Antifungal Agents; Boric Acids; Candida albicans; Candidiasis, Oral; Cetrimonium; Cetrimonium Compounds; Denture, Complete; Drug Resistance, Microbial; Humans; Miconazole; Microbial Sensitivity Tests; Nystatin; Periodic Acid; Silver Nitrate; Sodium Selenite; Stomatitis, Denture

2000
Adhesion of oral Candida albicans isolates to denture acrylic following limited exposure to antifungal agents.
    Archives of oral biology, 1998, Volume: 43, Issue:12

    Candidal adherence to denture acrylic surfaces is implicated as the first step in the pathogenesis of Candida-associated denture stomatitis, the most prevalent form of oral candidosis in the West. This condition is treated by topically administered antifungal agents, mainly belonging to the polyenes and azoles. As the intraoral concentrations of antifungals fluctuate considerably due to the dynamics of the oral environment, the effect of short exposure to sublethal concentrations of antifungals on the adhesion of Candida albicans to denture acrylic surfaces was investigated. Seven oral C. albicans isolates were exposed to four-eight times minimum inhibitory concentrations (MIC) of five antifungal drugs, nystatin, amphotericin B, 5-fluorocytosine, ketoconazole and fluconazole, for 1 h. After removing the drug (by repeated washing) the adhesion of these isolates to acrylic strips was assessed by an in vitro adhesion assay. Exposure to antifungal agents significantly reduced the adherence of all seven C. albicans isolates to denture acrylic. The mean percentage reductions of adhesion after limited exposure to nystatin, amphotericin B, 5-fluorocytosine, ketoconazole and fluconazole were 86.48, 90.85, 66.72, 65.88 and 47.42%, respectively. These findings indicate that subtherapeutic doses of antifungals may modulate oral candidal colonization. Further, these results may have an important bearing on dosage regimens currently employed in treating oral candidosis.

    Topics: Adhesiveness; Administration, Topical; Amphotericin B; Analysis of Variance; Antifungal Agents; Candida albicans; Candidiasis, Oral; Denture Bases; Drug Administration Schedule; Fluconazole; Flucytosine; Humans; Image Processing, Computer-Assisted; Ketoconazole; Mouth; Nystatin; Polymethyl Methacrylate; Stomatitis, Denture; Surface Properties; Time Factors

1998
Quantitative relationship between yeast and bacteria in denture-induced stomatitis.
    Scandinavian journal of dental research, 1983, Volume: 91, Issue:2

    Quantitative cultural studies of yeasts and bacteria were made from 7-day-old denture plaque accumulate on pieces of self-adhesive tape stuck on the fitting surface of the maxillary denture in 17 edentulous subjects with healthy oral mucosa and in 27 patients affected with denture-induced stomatitis. Significantly higher numbers of yeasts and bacteria were cultured in the stomatitis patients than in the controls. This indicates that the rate of plaque formation is increased in patients with denture-induced stomatitis. Yeasts usually constituted less than 1% of the anaerobic bacterial counts, but the percentage of yeasts was significantly higher in the stomatitis patients than in the controls. There was a significant correlation between initially higher yeast counts and improvement of the clinical condition of the palatal mucosa following antimycotic treatment. In some patients only bacteria were grown and antimycotic treatment had no effect. The study supported the contention that yeast antigens and toxins of denture plaque are significant factors in initiation and maintenance of denture-induced stomatitis. However, bacteria may also be involved as pathogens.

    Topics: Aged; Amphotericin B; Bacteria; Denture, Complete; Humans; Middle Aged; Stomatitis; Stomatitis, Denture; Yeasts

1983
Studies on oral yeast infection, with emphasis on denture stomatitis.
    Den Norske tannlaegeforenings tidende, 1976, Volume: 86, Issue:11

    Topics: Amphotericin B; Animals; Candidiasis, Oral; Chlorhexidine; Dental Plaque; Humans; Hydrogen-Ion Concentration; Saliva; Salivation; Stomatitis; Stomatitis, Denture

1976
Denture stomatitis. Relapse tendency and removal of acquired discolourations in long-term denture disinfection with chlorhexidine.
    Acta odontologica Scandinavica, 1975, Volume: 33, Issue:2

    Five patients with denture stomatitis were initially treated for 14 days with a combination of amphotericin B lozenges and denture soaking in 0.2% chlorhexidine. To prevent recurrence the dentures were then kept overnight in 0.2% chlorhexidine during five months. No relapse occurred, but the dentures (all-acrylic) became heavily discoloured by chlorhexidine. During this period fungi could not be grown either on palatal or on maxillar denture agar models, and clinical signs and symptoms were reduced further. At the end of treatment hypochlorite was used to remove chlorhexidine-induced denture stain. Brushing and soaking (0.16%) proved more efficient than brushing alone, and when a 0.60% solution was used, the stains were generally eliminated in two hours. Hypochlorites in the prevention and removal of chlorhexidine discolourations deserve further attention.

    Topics: Aged; Amphotericin B; Biguanides; Chlorhexidine; Denture, Complete; Disinfection; Female; Humans; Recurrence; Stomatitis; Stomatitis, Denture; Time Factors

1975
Oral infections with Candida albicans.
    Scottish medical journal, 1973, Volume: 18, Issue:6

    Topics: Amphotericin B; Biopsy; Candida albicans; Candidiasis, Oral; Cheilitis; Diabetes Complications; Endocrine System Diseases; Fluorescent Antibody Technique; Humans; Immunity, Cellular; Immunologic Deficiency Syndromes; Leukoplakia, Oral; Metabolic Diseases; Nutrition Disorders; Nystatin; Sjogren's Syndrome; Stomatitis, Denture

1973
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