Page last updated: 2024-10-22

ambroxol and Cough

ambroxol has been researched along with Cough in 19 studies

Ambroxol: A metabolite of BROMHEXINE that stimulates mucociliary action and clears the air passages in the respiratory tract. It is usually administered as the hydrochloride.

Cough: A sudden, audible expulsion of air from the lungs through a partially closed glottis, preceded by inhalation. It is a protective response that serves to clear the trachea, bronchi, and/or lungs of irritants and secretions, or to prevent aspiration of foreign materials into the lungs.

Research Excerpts

ExcerptRelevanceReference
"To evaluate the efficacy and safety of a combination drug containing ambroxol, guaifenesin, and levosalbutamol, oral solution, versus Ascoril Expectorant, syrup (combination of bromhexine, guaifenesin, and salbutamol) in the treatment of productive cough in adult patients with acute bronchitis."9.69[Evaluation of the efficacy and safety of a combination drug containing ambroxol, guaifenesin, and levosalbutamol versus a fixed-dose combination of bromhexine/guaifenesin/salbutamol in the treatment of productive cough in adult patients with acute bronch ( Esaulova, NA; Leshchenko, IV; Viktorova, IA; Zaitsev, AA, 2023)
"This study was designed to examine the efficacy and tolerability of ambroxol (Ambrosol) on the symptomatology of chronic bronchitis among in- and out-patients."9.08[Clinical evaluation of efficacy and tolerance of oral treatment with ambroxol in patients with chronic bronchitis]. ( Michnar, M; Milanowski, J, 1996)
"Twenty-three patients with exacerbations of chronic bronchitis were divided in two groups in a randomized fashion receiving either amoxicillin 1500 mg/d (n = 13) or amoxicillin 1500 mg/d associated with the mucolytic drug ambroxol 90 mg/d (n = 10)."9.06Ambroxol plus amoxicillin in the treatment of exacerbations of chronic bronchitis. ( Corazza, C; Fernández, M; Guerreiro, RB; Peralta, J; Poderoso, JJ; Wiemeyer, JC, 1987)
" Ambroxol hydrochloride (AH), a respiratory tract lubricant and expectorant, is often used to treat chronic respiratory diseases, such as bronchial asthma, emphysema, tuberculosis, and cough."8.31Baicalin/ambroxol hydrochloride combined dry powder inhalation formulation targeting lung delivery for treatment of idiopathic pulmonary fibrosis: Fabrication, characterization, pharmacokinetics, and pharmacodynamics. ( Deng, X; Guo, P; He, J; Jia, B; Li, J; Liu, Z; Peng, H; Pi, J; Qi, D; Zhang, Y, 2023)
"To evaluate the efficacy and safety of Bronchosol® herbal syrup in comparison to ambroxol preparations in the treatment of acute bronchitis in adult patients."7.81[Efficacy and safety of acute bronchitis treatment in adults--a comparison of Bronchosol® syrup and synthetic preparations with ambroxol. Results of observational study]. ( Fal, AM; Schönknecht, K, 2015)
"We examined the involvement of tetrodotoxin (TTX)-resistant sodium channels in the peripheral mechanisms of the cough reflex in mice."7.77Possible involvement of tetrodotoxin-resistant sodium channels in cough reflex. ( Asato, M; Hayashi, SS; Ishikawa, Y; Kamei, J; Nakanishi, Y; Ohsawa, M, 2011)
"This study was designed to evaluate the "real life" behavior of consumers with non-prescription access to an ambroxol cough syrup with special focus on tolerability and the pattern of product usage."7.73Safety and usage pattern of an over-the-counter ambroxol cough syrup: a community pharmacy-based cohort study. ( Gillissen, A; Hämmerlein, A; Hinkel, U; Schulz, M; Weis, G, 2006)
"To evaluate the efficacy and safety of a combination drug containing ambroxol, guaifenesin, and levosalbutamol, oral solution, versus Ascoril Expectorant, syrup (combination of bromhexine, guaifenesin, and salbutamol) in the treatment of productive cough in adult patients with acute bronchitis."5.69[Evaluation of the efficacy and safety of a combination drug containing ambroxol, guaifenesin, and levosalbutamol versus a fixed-dose combination of bromhexine/guaifenesin/salbutamol in the treatment of productive cough in adult patients with acute bronch ( Esaulova, NA; Leshchenko, IV; Viktorova, IA; Zaitsev, AA, 2023)
"Rengalin liquid formulation on the basis of antibodies to bradikinin histamine and morphine was specially designed for the treatment of cough in children."5.19[Rengalin, a novel drug for treatment of cough in children. Intermediate data on multicentre, comparative randomized clinical trial]. ( Baltserovich, NB; Galustyan, AN; Geppe, NA; Kamaev, AV; Kondyurina, EG; Laleko, SL; Lazareva, SG; Melnikova, IM; Mikhalkova, EV; Pak, TE; Perminova, OA; Sabitov, AU; Spivakovsky, YM; Zhiglinskaya, OV, 2014)
"This study was designed to examine the efficacy and tolerability of ambroxol (Ambrosol) on the symptomatology of chronic bronchitis among in- and out-patients."5.08[Clinical evaluation of efficacy and tolerance of oral treatment with ambroxol in patients with chronic bronchitis]. ( Michnar, M; Milanowski, J, 1996)
"Twenty-three patients with exacerbations of chronic bronchitis were divided in two groups in a randomized fashion receiving either amoxicillin 1500 mg/d (n = 13) or amoxicillin 1500 mg/d associated with the mucolytic drug ambroxol 90 mg/d (n = 10)."5.06Ambroxol plus amoxicillin in the treatment of exacerbations of chronic bronchitis. ( Corazza, C; Fernández, M; Guerreiro, RB; Peralta, J; Poderoso, JJ; Wiemeyer, JC, 1987)
" Ambroxol hydrochloride (AH), a respiratory tract lubricant and expectorant, is often used to treat chronic respiratory diseases, such as bronchial asthma, emphysema, tuberculosis, and cough."4.31Baicalin/ambroxol hydrochloride combined dry powder inhalation formulation targeting lung delivery for treatment of idiopathic pulmonary fibrosis: Fabrication, characterization, pharmacokinetics, and pharmacodynamics. ( Deng, X; Guo, P; He, J; Jia, B; Li, J; Liu, Z; Peng, H; Pi, J; Qi, D; Zhang, Y, 2023)
"Nine hundred sixty-five pharmacy customers purchasing one of four branded ambroxol formulations (extended release capsules, adult syrup, pediatric syrup and soft pastilles) filled a questionnaire including a patient-adapted version of the Bronchitis Severity Scale, several questions on degree of impairment by acute cough, time to onset of symptom relief and duration of treatment."3.88Characterization of differential patient profiles and therapeutic responses of pharmacy customers for four ambroxol formulations. ( Beeh, KM; Gräter, H; Kardos, P; Michel, MC; Mueck, T; Sent, U, 2018)
"To evaluate the efficacy and safety of Bronchosol® herbal syrup in comparison to ambroxol preparations in the treatment of acute bronchitis in adult patients."3.81[Efficacy and safety of acute bronchitis treatment in adults--a comparison of Bronchosol® syrup and synthetic preparations with ambroxol. Results of observational study]. ( Fal, AM; Schönknecht, K, 2015)
"We examined the involvement of tetrodotoxin (TTX)-resistant sodium channels in the peripheral mechanisms of the cough reflex in mice."3.77Possible involvement of tetrodotoxin-resistant sodium channels in cough reflex. ( Asato, M; Hayashi, SS; Ishikawa, Y; Kamei, J; Nakanishi, Y; Ohsawa, M, 2011)
"The aim of this study was to follow the changes in the cough reflex after administration of ambroxol in the dose of 10 mg/kg body weight."3.70[Ambroxol and protective reflexes of the respiratory tract]. ( Franová, S; Nemceková, E; Nosálóvá, G, 1998)
"Results."2.79[Therapeutic modalities for the management of cough associated with acute respiratory viral infection, effective in an otolaryngologist's practice]. ( Korostelev, SA; Mitiuk, AM; Ovchinnikov, AI; Paniakina, MA, 2014)

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-19905 (26.32)18.7374
1990's2 (10.53)18.2507
2000's2 (10.53)29.6817
2010's7 (36.84)24.3611
2020's3 (15.79)2.80

Authors

AuthorsStudies
Zaitsev, AA1
Leshchenko, IV1
Esaulova, NA1
Viktorova, IA1
Qi, D1
Jia, B1
Peng, H1
He, J1
Pi, J1
Guo, P1
Zhang, Y1
Deng, X1
Li, J1
Liu, Z1
Elgamasy, S1
Kamel, MG1
Ghozy, S1
Khalil, A1
Morra, ME1
Islam, SMS1
Kardos, P1
Beeh, KM1
Sent, U1
Mueck, T1
Gräter, H1
Michel, MC1
Dhar, R1
Ovchinnikov, AI1
Paniakina, MA1
Korostelev, SA1
Mitiuk, AM1
Geppe, NA1
Kondyurina, EG1
Galustyan, AN1
Pak, TE1
Baltserovich, NB1
Zhiglinskaya, OV1
Kamaev, AV1
Lazareva, SG1
Laleko, SL1
Melnikova, IM1
Mikhalkova, EV1
Perminova, OA1
Sabitov, AU1
Spivakovsky, YM1
Fal, AM1
Schönknecht, K1
Chang, CY1
Sachs, HC1
Lee, CE1
Yakoot, M1
Salem, A1
Omar, AM1
Kamei, J1
Nakanishi, Y1
Ishikawa, Y1
Hayashi, SS1
Asato, M1
Ohsawa, M1
Schulz, M1
Hämmerlein, A1
Hinkel, U1
Weis, G1
Gillissen, A1
Berni, M1
Collina, A1
Zavattini, G1
Michnar, M1
Milanowski, J1
Nemceková, E1
Nosálóvá, G1
Franová, S1
Renovanz, HD2
von Seefeld, H1
Papendick, U1
Heissler, K1
Schuster, D1
Germouty, J1
Jirou-Najou, JL1
Peralta, J1
Poderoso, JJ1
Corazza, C1
Fernández, M1
Guerreiro, RB1
Wiemeyer, JC1

Reviews

1 review available for ambroxol and Cough

ArticleYear
Role of mucolytics in wet cough.
    The Journal of the Association of Physicians of India, 2013, Volume: 61, Issue:5 Suppl

    Topics: Ambroxol; Asthma; Bronchodilator Agents; Cholinergic Antagonists; Cough; Cystic Fibrosis; Expectoran

2013

Trials

7 trials available for ambroxol and Cough

ArticleYear
[Evaluation of the efficacy and safety of a combination drug containing ambroxol, guaifenesin, and levosalbutamol versus a fixed-dose combination of bromhexine/guaifenesin/salbutamol in the treatment of productive cough in adult patients with acute bronch
    Terapevticheskii arkhiv, 2023, Apr-26, Volume: 95, Issue:3

    Topics: Acute Disease; Adult; Albuterol; Ambroxol; Bromhexine; Bronchitis; Cough; Drug Combinations; Expecto

2023
[Therapeutic modalities for the management of cough associated with acute respiratory viral infection, effective in an otolaryngologist's practice].
    Vestnik otorinolaringologii, 2014, Issue:2

    Topics: Acute Disease; Adult; Albuterol; Ambroxol; Bromhexine; Bronchodilator Agents; Cough; Drug Combinatio

2014
[Rengalin, a novel drug for treatment of cough in children. Intermediate data on multicentre, comparative randomized clinical trial].
    Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic], 2014, Volume: 59, Issue:7-8

    Topics: Administration, Oral; Adolescent; Ambroxol; Antibodies, Neutralizing; Antitussive Agents; Bradykinin

2014
Clinical efficacy of farcosolvin syrup (ambroxol-theophylline-guaiphenesin mixture) in the treatment of acute exacerbation of chronic bronchitis.
    International journal of chronic obstructive pulmonary disease, 2010, Aug-09, Volume: 5

    Topics: Aged; Ambroxol; Bronchitis, Chronic; Bronchodilator Agents; Cough; Drug Combinations; Egypt; Expecto

2010
[Clinical evaluation of efficacy and tolerance of oral treatment with ambroxol in patients with chronic bronchitis].
    Pneumonologia i alergologia polska, 1996, Volume: 64 Suppl 1

    Topics: Administration, Oral; Adult; Aged; Ambroxol; Anti-Bacterial Agents; Bronchitis; Chronic Disease; Cou

1996
Clinical efficacy of ambroxol in the treatment of bronchial stasis. Clinical trial in 120 patients at two different doses.
    Respiration; international review of thoracic diseases, 1987, Volume: 51 Suppl 1

    Topics: Adult; Aged; Ambroxol; Bromhexine; Bronchial Diseases; Clinical Trials as Topic; Cough; Dose-Respons

1987
Ambroxol plus amoxicillin in the treatment of exacerbations of chronic bronchitis.
    Arzneimittel-Forschung, 1987, Volume: 37, Issue:8

    Topics: Adult; Aged; Aged, 80 and over; Ambroxol; Amoxicillin; Blood Gas Analysis; Bromhexine; Bronchitis; C

1987

Other Studies

11 other studies available for ambroxol and Cough

ArticleYear
Baicalin/ambroxol hydrochloride combined dry powder inhalation formulation targeting lung delivery for treatment of idiopathic pulmonary fibrosis: Fabrication, characterization, pharmacokinetics, and pharmacodynamics.
    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2023, Volume: 188

    Topics: Administration, Inhalation; Ambroxol; Cough; Dry Powder Inhalers; Humans; Idiopathic Pulmonary Fibro

2023
First case of focal epilepsy associated with SARS-coronavirus-2.
    Journal of medical virology, 2020, Volume: 92, Issue:10

    Topics: Acetaminophen; Acetylcysteine; Aged; Ambroxol; Anticonvulsants; Cough; COVID-19; COVID-19 Drug Treat

2020
Characterization of differential patient profiles and therapeutic responses of pharmacy customers for four ambroxol formulations.
    BMC pharmacology & toxicology, 2018, 07-04, Volume: 19, Issue:1

    Topics: Adolescent; Adult; Ambroxol; Bronchitis; Child; Child, Preschool; Cough; Dosage Forms; Drug Compound

2018
[Efficacy and safety of acute bronchitis treatment in adults--a comparison of Bronchosol® syrup and synthetic preparations with ambroxol. Results of observational study].
    Wiadomosci lekarskie (Warsaw, Poland : 1960), 2015, Volume: 68, Issue:2

    Topics: Acute Disease; Adult; Ambroxol; Antitussive Agents; Bronchitis; Cough; Expectorants; Female; Humans;

2015
Unexpected infant deaths associated with use of cough and cold medications.
    Pediatrics, 2009, Volume: 123, Issue:2

    Topics: Ambroxol; Cause of Death; Common Cold; Cough; Expectorants; Humans; Infant; Nonprescription Drugs

2009
Possible involvement of tetrodotoxin-resistant sodium channels in cough reflex.
    European journal of pharmacology, 2011, Feb-10, Volume: 652, Issue:1-3

    Topics: Ambroxol; Animals; Antitussive Agents; Cough; Dose-Response Relationship, Drug; Male; Mice; Mice, In

2011
Safety and usage pattern of an over-the-counter ambroxol cough syrup: a community pharmacy-based cohort study.
    International journal of clinical pharmacology and therapeutics, 2006, Volume: 44, Issue:9

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Ambroxol; Child; Cohort Studies; Cough; Expectorants; Fe

2006
[Ambroxol in bronchopulmonary pathology in children].
    La Clinica terapeutica, 1983, Sep-15, Volume: 106, Issue:5

    Topics: Ambroxol; Bromhexine; Bronchial Diseases; Bronchitis; Carbocysteine; Child; Child, Preschool; Cough;

1983
[Ambroxol and protective reflexes of the respiratory tract].
    Bratislavske lekarske listy, 1998, Volume: 99, Issue:2

    Topics: Ambroxol; Animals; Cats; Cough; Expectorants; Guinea Pigs; Muscle Contraction; Muscle, Smooth; Refle

1998
[Tussometry. II. Tussometry for the monitoring of drug effects].
    Wiener medizinische Wochenschrift. Supplement, 1979, Volume: 58

    Topics: Ambroxol; Antitussive Agents; Bronchodilator Agents; Clenbuterol; Cough; Humans; Methods; Morpholine

1979
[Drug evaluation in children with special reference to functional parameters in asthma therapy].
    Fortschritte der Medizin, 1977, Mar-10, Volume: 95, Issue:10

    Topics: Ambroxol; Asthma; Child; Child, Preschool; Cough; Drug Evaluation; Human Rights; Humans; Infant; Inf

1977