am 251 has been researched along with Depression in 11 studies
AM 251: an analog of SR141716A; structure given in first source
AM-251 : A carbohydrazide obtained by formal condensation of the carboxy group of 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid with the amino group of 1-aminopiperidine. An antagonist at the CB1 cannabinoid receptor.
Depression: Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders.
Excerpt | Relevance | Reference |
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"Depression is a common mental disorder in adolescents, with a prevalence rate of 5." | 1.48 | Effects of rTMS on Hippocampal Endocannabinoids and Depressive-like Behaviors in Adolescent Rats. ( Fang, G; Wang, Y, 2018) |
"05-10 μg/mouse) produced antidepressant-like effect dose-dependently, whereas influenced the MBB in a biphasic manner (produced a U-shaped dose-response curve)." | 1.37 | Involvement of endocannabinoids in antidepressant and anti-compulsive effect of fluoxetine in mice. ( Jain, NS; Manna, SS; Umathe, SN, 2011) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 1 (9.09) | 29.6817 |
2010's | 8 (72.73) | 24.3611 |
2020's | 2 (18.18) | 2.80 |
Authors | Studies |
---|---|
Rezaie, M | 1 |
Nasehi, M | 1 |
Vaseghi, S | 1 |
Alimohammadzadeh, K | 1 |
Islami Vaghar, M | 1 |
Mohammadi-Mahdiabadi-Hasani, MH | 1 |
Zarrindast, MR | 1 |
Malvestio, RB | 1 |
Medeiros, P | 1 |
Negrini-Ferrari, SE | 1 |
Oliveira-Silva, M | 1 |
Medeiros, AC | 1 |
Padovan, CM | 1 |
Luongo, L | 1 |
Maione, S | 1 |
Coimbra, NC | 1 |
de Freitas, RL | 1 |
Wośko, S | 1 |
Serefko, A | 1 |
Szopa, A | 1 |
Wlaź, P | 1 |
Wróbel, A | 1 |
Wlaź, A | 1 |
Górska, J | 1 |
Poleszak, E | 1 |
Fang, G | 1 |
Wang, Y | 1 |
Wang, HN | 1 |
Wang, L | 1 |
Zhang, RG | 1 |
Chen, YC | 1 |
Liu, L | 1 |
Gao, F | 1 |
Nie, H | 1 |
Hou, WG | 1 |
Peng, ZW | 1 |
Tan, Q | 1 |
Ostadhadi, S | 1 |
Haj-Mirzaian, A | 3 |
Nikoui, V | 1 |
Kordjazy, N | 1 |
Dehpour, AR | 2 |
de Morais, H | 1 |
de Souza, CP | 1 |
da Silva, LM | 1 |
Ferreira, DM | 1 |
Baggio, CH | 1 |
Vanvossen, AC | 1 |
Cristina de Carvalho, M | 1 |
da Silva-Santos, JE | 1 |
Bertoglio, LJ | 1 |
Cunha, JM | 1 |
Zanoveli, JM | 1 |
Amini-Khoei, H | 1 |
Amiri, S | 1 |
Ghesmati, M | 1 |
Zahir, M | 1 |
Shafaroodi, H | 1 |
Umathe, SN | 1 |
Manna, SS | 1 |
Jain, NS | 1 |
Hayase, T | 1 |
McLaughlin, RJ | 1 |
Hill, MN | 1 |
Morrish, AC | 1 |
Gorzalka, BB | 1 |
11 other studies available for am 251 and Depression
Article | Year |
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The interaction effect of sleep deprivation and cannabinoid type 1 receptor in the CA1 hippocampal region on passive avoidance memory, depressive-like behavior and locomotor activity in rats.
Topics: Animals; Arachidonic Acids; Avoidance Learning; Behavior, Animal; CA1 Region, Hippocampal; Cannabino | 2021 |
Cannabidiol in the prelimbic cortex modulates the comorbid condition between the chronic neuropathic pain and depression-like behaviour in rats: The role of medial prefrontal cortex 5-HT
Topics: Animals; Cannabidiol; Chronic Disease; Cobalt; Depression; Limbic System; Microinjections; Neuralgia | 2021 |
CB
Topics: Animals; Antidepressive Agents; Behavior Rating Scale; Depression; Drug Synergism; Hypnotics and Sed | 2018 |
Effects of rTMS on Hippocampal Endocannabinoids and Depressive-like Behaviors in Adolescent Rats.
Topics: Age Factors; Animals; Depression; Endocannabinoids; Hippocampus; Male; Microinjections; Piperidines; | 2018 |
Anti-depressive mechanism of repetitive transcranial magnetic stimulation in rat: the role of the endocannabinoid system.
Topics: Analysis of Variance; Animals; bcl-2-Associated X Protein; Brain-Derived Neurotrophic Factor; Bromod | 2014 |
Involvement of opioid system in antidepressant-like effect of the cannabinoid CB1 receptor inverse agonist AM-251 after physical stress in mice.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Depression; Drug Inverse Agonism; Hindlimb Suspens | 2016 |
Anandamide reverses depressive-like behavior, neurochemical abnormalities and oxidative-stress parameters in streptozotocin-diabetic rats: Role of CB1 receptors.
Topics: Animals; Arachidonic Acids; Behavior, Animal; Brain Chemistry; Calcium Channel Blockers; Depression; | 2016 |
Activation of cannabinoid receptors elicits antidepressant-like effects in a mouse model of social isolation stress.
Topics: Animals; Antidepressive Agents; Anxiety; Behavior, Animal; Benzoxazines; Cannabinoid Receptor Agonis | 2017 |
Involvement of endocannabinoids in antidepressant and anti-compulsive effect of fluoxetine in mice.
Topics: Animals; Antidepressive Agents; Arachidonic Acids; Benzamides; Cannabinoid Receptor Modulators; Carb | 2011 |
Differential effects of TRPV1 receptor ligands against nicotine-induced depression-like behaviors.
Topics: Animals; Antidepressive Agents; Arachidonic Acids; Capsaicin; Depression; Dopamine; Endocannabinoids | 2011 |
Local enhancement of cannabinoid CB1 receptor signalling in the dorsal hippocampus elicits an antidepressant-like effect.
Topics: Analysis of Variance; Animals; Antidepressive Agents; Behavior, Animal; Benzamides; Cannabinoid Rece | 2007 |