Page last updated: 2024-10-22

am 251 and Depression

am 251 has been researched along with Depression in 11 studies

AM 251: an analog of SR141716A; structure given in first source
AM-251 : A carbohydrazide obtained by formal condensation of the carboxy group of 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid with the amino group of 1-aminopiperidine. An antagonist at the CB1 cannabinoid receptor.

Depression: Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders.

Research Excerpts

ExcerptRelevanceReference
"Depression is a common mental disorder in adolescents, with a prevalence rate of 5."1.48Effects of rTMS on Hippocampal Endocannabinoids and Depressive-like Behaviors in Adolescent Rats. ( Fang, G; Wang, Y, 2018)
"05-10 μg/mouse) produced antidepressant-like effect dose-dependently, whereas influenced the MBB in a biphasic manner (produced a U-shaped dose-response curve)."1.37Involvement of endocannabinoids in antidepressant and anti-compulsive effect of fluoxetine in mice. ( Jain, NS; Manna, SS; Umathe, SN, 2011)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (9.09)29.6817
2010's8 (72.73)24.3611
2020's2 (18.18)2.80

Authors

AuthorsStudies
Rezaie, M1
Nasehi, M1
Vaseghi, S1
Alimohammadzadeh, K1
Islami Vaghar, M1
Mohammadi-Mahdiabadi-Hasani, MH1
Zarrindast, MR1
Malvestio, RB1
Medeiros, P1
Negrini-Ferrari, SE1
Oliveira-Silva, M1
Medeiros, AC1
Padovan, CM1
Luongo, L1
Maione, S1
Coimbra, NC1
de Freitas, RL1
Wośko, S1
Serefko, A1
Szopa, A1
Wlaź, P1
Wróbel, A1
Wlaź, A1
Górska, J1
Poleszak, E1
Fang, G1
Wang, Y1
Wang, HN1
Wang, L1
Zhang, RG1
Chen, YC1
Liu, L1
Gao, F1
Nie, H1
Hou, WG1
Peng, ZW1
Tan, Q1
Ostadhadi, S1
Haj-Mirzaian, A3
Nikoui, V1
Kordjazy, N1
Dehpour, AR2
de Morais, H1
de Souza, CP1
da Silva, LM1
Ferreira, DM1
Baggio, CH1
Vanvossen, AC1
Cristina de Carvalho, M1
da Silva-Santos, JE1
Bertoglio, LJ1
Cunha, JM1
Zanoveli, JM1
Amini-Khoei, H1
Amiri, S1
Ghesmati, M1
Zahir, M1
Shafaroodi, H1
Umathe, SN1
Manna, SS1
Jain, NS1
Hayase, T1
McLaughlin, RJ1
Hill, MN1
Morrish, AC1
Gorzalka, BB1

Other Studies

11 other studies available for am 251 and Depression

ArticleYear
The interaction effect of sleep deprivation and cannabinoid type 1 receptor in the CA1 hippocampal region on passive avoidance memory, depressive-like behavior and locomotor activity in rats.
    Behavioural brain research, 2021, 01-01, Volume: 396

    Topics: Animals; Arachidonic Acids; Avoidance Learning; Behavior, Animal; CA1 Region, Hippocampal; Cannabino

2021
Cannabidiol in the prelimbic cortex modulates the comorbid condition between the chronic neuropathic pain and depression-like behaviour in rats: The role of medial prefrontal cortex 5-HT
    Brain research bulletin, 2021, Volume: 174

    Topics: Animals; Cannabidiol; Chronic Disease; Cobalt; Depression; Limbic System; Microinjections; Neuralgia

2021
CB
    The Journal of pharmacy and pharmacology, 2018, Volume: 70, Issue:4

    Topics: Animals; Antidepressive Agents; Behavior Rating Scale; Depression; Drug Synergism; Hypnotics and Sed

2018
Effects of rTMS on Hippocampal Endocannabinoids and Depressive-like Behaviors in Adolescent Rats.
    Neurochemical research, 2018, Volume: 43, Issue:9

    Topics: Age Factors; Animals; Depression; Endocannabinoids; Hippocampus; Male; Microinjections; Piperidines;

2018
Anti-depressive mechanism of repetitive transcranial magnetic stimulation in rat: the role of the endocannabinoid system.
    Journal of psychiatric research, 2014, Volume: 51

    Topics: Analysis of Variance; Animals; bcl-2-Associated X Protein; Brain-Derived Neurotrophic Factor; Bromod

2014
Involvement of opioid system in antidepressant-like effect of the cannabinoid CB1 receptor inverse agonist AM-251 after physical stress in mice.
    Clinical and experimental pharmacology & physiology, 2016, Volume: 43, Issue:2

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Depression; Drug Inverse Agonism; Hindlimb Suspens

2016
Anandamide reverses depressive-like behavior, neurochemical abnormalities and oxidative-stress parameters in streptozotocin-diabetic rats: Role of CB1 receptors.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2016, Volume: 26, Issue:10

    Topics: Animals; Arachidonic Acids; Behavior, Animal; Brain Chemistry; Calcium Channel Blockers; Depression;

2016
Activation of cannabinoid receptors elicits antidepressant-like effects in a mouse model of social isolation stress.
    Brain research bulletin, 2017, Volume: 130

    Topics: Animals; Antidepressive Agents; Anxiety; Behavior, Animal; Benzoxazines; Cannabinoid Receptor Agonis

2017
Involvement of endocannabinoids in antidepressant and anti-compulsive effect of fluoxetine in mice.
    Behavioural brain research, 2011, Sep-30, Volume: 223, Issue:1

    Topics: Animals; Antidepressive Agents; Arachidonic Acids; Benzamides; Cannabinoid Receptor Modulators; Carb

2011
Differential effects of TRPV1 receptor ligands against nicotine-induced depression-like behaviors.
    BMC pharmacology, 2011, Jul-18, Volume: 11

    Topics: Animals; Antidepressive Agents; Arachidonic Acids; Capsaicin; Depression; Dopamine; Endocannabinoids

2011
Local enhancement of cannabinoid CB1 receptor signalling in the dorsal hippocampus elicits an antidepressant-like effect.
    Behavioural pharmacology, 2007, Volume: 18, Issue:5-6

    Topics: Analysis of Variance; Animals; Antidepressive Agents; Behavior, Animal; Benzamides; Cannabinoid Rece

2007