Page last updated: 2024-11-07

aldosterone and Pulmonary Hypertension

aldosterone has been researched along with Pulmonary Hypertension in 29 studies

Research Excerpts

ExcerptRelevanceReference
"Since the renin-angiotensin-aldosterone system and atrial natriuretic factor are directly involved in the regulation of hemodynamics and structural alterations in the circulatory system, the interest of investigators in the observed changes in this system during exogenous hypoxia and the resultant development of high-altitude pulmonary hypertension is quite understandable."7.69Atrial natriuretic factor in high-altitude pulmonary hypertension: the influence of acute hypoxia on plasma atrial natriuretic factor, renin, and aldosterone concentrations in highlanders with initially normal or elevated pulmonary artery pressure and wit ( Batyraliev, TA; Birand, A; Kudaiberdieva, GZ; Niyazova, ZA; Soodanbekova, GK, 1995)
"To investigate the physiological role of atrial natriuretic factor (ANF) in patients with hypoxic pulmonary hypertension secondary to chronic obstructive lung disease (COLD), we infused synthetic alpha-human ANF in seven such patients, and investigated the physiological correlates to circulating peptide levels in 24 patients with COLD."7.67Atrial natriuretic factor in chronic obstructive lung disease with pulmonary hypertension. Physiological correlates and response to peptide infusion. ( Adnot, S; Andrivet, P; Braquet, P; Brun-Buisson, C; Chabrier, PE; Piquet, J; Plas, P; Roudot-Thoraval, F, 1989)
"MRAs are a recognized treatment for heart failure and hypertension."6.66Aldosterone and Mineralocorticoid Receptor Antagonists on Pulmonary Hypertension and Right Ventricular Failure: A Review. ( Mohammadpour, AH; Omidkhoda, N; Sahebkar, A; Sathyapalan, T; Vakilian, F, 2020)
" We evaluated the efficacy of MR antagonism by spironolactone in two experimental PH models; mouse chronic hypoxia-induced PH (prevention model) and rat monocrotaline-induced PH (prevention and treatment models)."3.79Mineralocorticoid receptor antagonism attenuates experimental pulmonary hypertension. ( Fanburg, BL; Hill, NS; Jaffe, IZ; Preston, IR; Sagliani, KD; Warburton, RR, 2013)
"Since the renin-angiotensin-aldosterone system and atrial natriuretic factor are directly involved in the regulation of hemodynamics and structural alterations in the circulatory system, the interest of investigators in the observed changes in this system during exogenous hypoxia and the resultant development of high-altitude pulmonary hypertension is quite understandable."3.69Atrial natriuretic factor in high-altitude pulmonary hypertension: the influence of acute hypoxia on plasma atrial natriuretic factor, renin, and aldosterone concentrations in highlanders with initially normal or elevated pulmonary artery pressure and wit ( Batyraliev, TA; Birand, A; Kudaiberdieva, GZ; Niyazova, ZA; Soodanbekova, GK, 1995)
"Administration of iopromide for pulmonary angiography in patients with pulmonary hypertension resulted in no appreciable hemodynamic alterations associated with the observed changes in atrial natriuretic peptide, antidiuretic hormone, and renin."3.69Pulmonary hypertension. Response of vasoactive peptides to a nonionic contrast medium in patients undergoing pulmonary angiography. ( Flueckiger, F; Horina, J; Preidler, K; Riepl, T; Saeed, M; Stiskal, MA; Szolar, DH; Watzinger, N, 1995)
"Angiotensin II (AT II), plasma renin activity (PRA) and aldosterone (Ald) were determined at 8:00 AM in sitting position for 30 minutes in 12 heathy nonsmokers, 50-60 years old, with normal functions of small airway, normal FEV1 and lung volumes, and in 23 patients with chronic bronchitis with or without emphysema."3.69[RAAS changes due to dysfunction of pulmonary ventilation]. ( Lin, Y; Ma, Y; Sun, M, 1996)
"To investigate the physiological role of atrial natriuretic factor (ANF) in patients with hypoxic pulmonary hypertension secondary to chronic obstructive lung disease (COLD), we infused synthetic alpha-human ANF in seven such patients, and investigated the physiological correlates to circulating peptide levels in 24 patients with COLD."3.67Atrial natriuretic factor in chronic obstructive lung disease with pulmonary hypertension. Physiological correlates and response to peptide infusion. ( Adnot, S; Andrivet, P; Braquet, P; Brun-Buisson, C; Chabrier, PE; Piquet, J; Plas, P; Roudot-Thoraval, F, 1989)
"The hemodynamic changes and plasma renin activity (PRA), angiotensin II (ATII), aldosterone (Ald) levels in 38 COPD patients with or without pulmonary hypertension were studied."3.67[Hemodynamic changes and their relationship with the renin-angiotensin-aldosterone system in chronic obstructive pulmonary disease]. ( Zen, GB, 1989)
"MRAs are a recognized treatment for heart failure and hypertension."2.66Aldosterone and Mineralocorticoid Receptor Antagonists on Pulmonary Hypertension and Right Ventricular Failure: A Review. ( Mohammadpour, AH; Omidkhoda, N; Sahebkar, A; Sathyapalan, T; Vakilian, F, 2020)
"Hyperaldosteronism has emerged as a promoter of pulmonary vascular disease in experimental animal models of PAH; however, the extent to which hyperaldosteronism is associated with PAH in patients is unknown."1.39Plasma aldosterone levels are elevated in patients with pulmonary arterial hypertension in the absence of left ventricular heart failure: a pilot study. ( Landzberg, MJ; Leopold, JA; Loscalzo, J; Maron, BA; Opotowsky, AR; Waxman, AB, 2013)
"Poor survival in pulmonary hypertension is known to be associated with unfavorable hemodynamic variables, including elevated right atrial pressure, elevated mean pulmonary artery pressure, and low cardiac index."1.32Plasma volume and outcome in pulmonary hypertension. ( Armstrong, R; Fouad-Tarazi, F; James, KB; Stelmach, K; Young, JB, 2003)
"Aldosterone excretion was in HL with EH substantially lower, and sodium excretion higher, than in a comparable group of lowland inhabitants."1.27Prevalence and clinical peculiarities of essential hypertension in a population living at high altitude. ( Dzhumagulova, AS; Meimanaliev, TS; Mirrakhimov, MM; Murataliev, TM; Rafibekova, ZhS; Shatemirova, KK, 1985)

Research

Studies (29)

TimeframeStudies, this research(%)All Research%
pre-19907 (24.14)18.7374
1990's7 (24.14)18.2507
2000's3 (10.34)29.6817
2010's10 (34.48)24.3611
2020's2 (6.90)2.80

Authors

AuthorsStudies
Mamazhakypov, A1
Hein, L1
Lother, A1
Omidkhoda, N1
Vakilian, F1
Mohammadpour, AH1
Sathyapalan, T1
Sahebkar, A1
Preston, IR1
Sagliani, KD1
Warburton, RR1
Hill, NS1
Fanburg, BL1
Jaffe, IZ1
Maron, BA5
Leopold, JA4
Calvier, L1
Legchenko, E1
Grimm, L1
Sallmon, H1
Hatch, A1
Plouffe, BD1
Schroeder, C1
Bauersachs, J1
Murthy, SK1
Hansmann, G1
Aghamohammadzadeh, R1
Zhang, YY2
Stephens, TE1
Arons, E1
Zaman, P1
Polach, KJ1
Matar, M1
Yung, LM1
Yu, PB1
Bowman, FP1
Opotowsky, AR2
Waxman, AB2
Loscalzo, J3
Bansal, S1
Badesch, D1
Bull, T1
Schrier, RW1
Farber, HW1
Walkey, AJ1
Alikhan, MM1
Yamanaka, R1
Otsuka, F1
Nakamura, K1
Yamashita, M1
Otani, H1
Takeda, M1
Matsumoto, Y1
Kusano, KF1
Ito, H1
Makino, H1
Chabot, A1
Jiang, BH1
Shi, Y1
Tardif, JC1
Dupuis, J1
White, K1
Chan, SY1
Handy, DE1
Mahoney, CE1
Landzberg, MJ1
HAYSLETT, JP1
FLINN, RB1
MULROW, PJ1
James, KB1
Stelmach, K1
Armstrong, R1
Young, JB1
Fouad-Tarazi, F1
Ciarka, A1
Vachièry, JL1
Houssière, A1
Gujic, M1
Stoupel, E1
Velez-Roa, S1
Naeije, R1
van de Borne, P1
Ikram, H1
Maslowski, AH1
Nicholls, MG1
Espiner, EA1
Hull, FT1
Alekseev, VG1
Tikhomirov, ES1
Gerasimov, GM1
Soodanbekova, GK1
Batyraliev, TA1
Niyazova, ZA1
Kudaiberdieva, GZ1
Birand, A1
Szolar, DH1
Saeed, M1
Flueckiger, F1
Preidler, K1
Stiskal, MA1
Watzinger, N1
Riepl, T1
Horina, J1
Kiely, DG1
Cargill, RI1
Wheeldon, NM1
Coutie, WJ1
Lipworth, BJ1
Lin, Y1
Sun, M1
Ma, Y1
Martyniuk, TV1
Chazova, IE1
Masenko, VP1
Volkov, VN1
Belenkov, IuN1
Oelz, O1
Maggiorini, M1
Ritter, M1
Noti, C1
Waber, U1
Vock, P1
Bärtsch, P1
Cardoso, PF1
Hsieh, CM1
Daniel, L1
Yokomise, H1
Kato, H1
Strangemore, BL1
Miller, JD1
Logan, AG1
Rakowski, H1
Patterson, GA1
Adnot, S1
Andrivet, P1
Chabrier, PE1
Piquet, J1
Plas, P1
Braquet, P1
Roudot-Thoraval, F1
Brun-Buisson, C1
Liu, LS1
Cheng, HY1
Chin, WJ1
Jin, HK1
Oparil, S1
Zen, GB1
Mirrakhimov, MM1
Rafibekova, ZhS1
Dzhumagulova, AS1
Meimanaliev, TS1
Murataliev, TM1
Shatemirova, KK1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Biomarkers in Congenital Heart Diseases and Pulmonary Arterial Hypertension[NCT04130243]380 participants (Anticipated)Observational [Patient Registry]2017-12-05Active, not recruiting
Addressing HyperteNsion and Diabetes Through Community-Engaged Systems in Puno, Peru (ANDES Study)[NCT05524987]1,068 participants (Anticipated)Interventional2022-11-30Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

4 reviews available for aldosterone and Pulmonary Hypertension

ArticleYear
Mineralocorticoid receptors in pulmonary hypertension and right heart failure: From molecular biology to therapeutic targeting.
    Pharmacology & therapeutics, 2022, Volume: 231

    Topics: Aldosterone; Animals; Endothelial Cells; Heart Failure; Humans; Hypertension, Pulmonary; Mice; Miner

2022
Aldosterone and Mineralocorticoid Receptor Antagonists on Pulmonary Hypertension and Right Ventricular Failure: A Review.
    Current pharmaceutical design, 2020, Volume: 26, Issue:31

    Topics: Aldosterone; Heart Failure; Humans; Hypertension, Pulmonary; Mineralocorticoid Receptor Antagonists;

2020
Emerging Concepts in the Molecular Basis of Pulmonary Arterial Hypertension: Part II: Neurohormonal Signaling Contributes to the Pulmonary Vascular and Right Ventricular Pathophenotype of Pulmonary Arterial Hypertension.
    Circulation, 2015, Jun-09, Volume: 131, Issue:23

    Topics: Aldosterone; Fibrosis; Heart Ventricles; Humans; Hypertension, Pulmonary; Neurotransmitter Agents; P

2015
[Pathophysiology, prevention and therapy of altitude pulmonary edema].
    Schweizerische medizinische Wochenschrift, 1992, Aug-04, Volume: 122, Issue:31-32

    Topics: Aldosterone; Altitude Sickness; Cell Membrane Permeability; Epinephrine; Humans; Hypertension, Pulmo

1992

Trials

3 trials available for aldosterone and Pulmonary Hypertension

ArticleYear
Role of vasopressin and aldosterone in pulmonary arterial hypertension: A pilot study.
    Contemporary clinical trials, 2009, Volume: 30, Issue:5

    Topics: Aldosterone; Health Status Indicators; Humans; Hypertension, Pulmonary; Mineralocorticoid Receptor A

2009
Atrial septostomy decreases sympathetic overactivity in pulmonary arterial hypertension.
    Chest, 2007, Volume: 131, Issue:6

    Topics: Adult; Aldosterone; Blood Pressure; Cardiac Output; Female; Heart Atria; Heart Rate; Heart Septum; H

2007
Haemodynamic and endocrine effects of type 1 angiotensin II receptor blockade in patients with hypoxaemic cor pulmonale.
    Cardiovascular research, 1997, Volume: 33, Issue:1

    Topics: Aged; Aldosterone; Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Biphen

1997

Other Studies

22 other studies available for aldosterone and Pulmonary Hypertension

ArticleYear
Mineralocorticoid receptor antagonism attenuates experimental pulmonary hypertension.
    American journal of physiology. Lung cellular and molecular physiology, 2013, May-15, Volume: 304, Issue:10

    Topics: Aldosterone; Animals; Arterial Pressure; Body Weight; Cardiac Output; Cell Proliferation; Fibrosis;

2013
The quest for biomarker discovery in pulmonary arterial hypertension: the right takes lessons from the left.
    Heart (British Cardiac Society), 2016, Volume: 102, Issue:5

    Topics: Aldosterone; Female; Galectin 3; Humans; Hypertension, Pulmonary; Male

2016
Galectin-3 and aldosterone as potential tandem biomarkers in pulmonary arterial hypertension.
    Heart (British Cardiac Society), 2016, Volume: 102, Issue:5

    Topics: Adult; Aged; Aldosterone; Biomarkers; Blood Proteins; Case-Control Studies; Enzyme-Linked Immunosorb

2016
Up-regulation of the mammalian target of rapamycin complex 1 subunit Raptor by aldosterone induces abnormal pulmonary artery smooth muscle cell survival patterns to promote pulmonary arterial hypertension.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2016, Volume: 30, Issue:7

    Topics: Adaptor Proteins, Signal Transducing; Aldosterone; Animals; Apoptosis; Cell Proliferation; Cell Surv

2016
The role of aldosterone in pulmonary venous hypertension.
    Chest, 2010, Volume: 137, Issue:2

    Topics: Aldosterone; Humans; Hypertension, Pulmonary; Renin-Angiotensin System; Risk Factors; Venous Pressur

2010
Involvement of the bone morphogenetic protein system in endothelin- and aldosterone-induced cell proliferation of pulmonary arterial smooth muscle cells isolated from human patients with pulmonary arterial hypertension.
    Hypertension research : official journal of the Japanese Society of Hypertension, 2010, Volume: 33, Issue:5

    Topics: Aldosterone; Analysis of Variance; Blotting, Western; Bone Morphogenetic Protein Receptors, Type II;

2010
Role of aldosterone on lung structural remodelling and right ventricular function in congestive heart failure.
    BMC cardiovascular disorders, 2011, Dec-02, Volume: 11

    Topics: Aldosterone; Animals; Cell Proliferation; Echocardiography; Heart Failure; Hypertension, Pulmonary;

2011
Aldosterone inactivates the endothelin-B receptor via a cysteinyl thiol redox switch to decrease pulmonary endothelial nitric oxide levels and modulate pulmonary arterial hypertension.
    Circulation, 2012, Aug-21, Volume: 126, Issue:8

    Topics: Aldosterone; Animals; Cells, Cultured; Cysteine; Disease Models, Animal; Endothelial Cells; Endothel

2012
Plasma aldosterone levels are elevated in patients with pulmonary arterial hypertension in the absence of left ventricular heart failure: a pilot study.
    European journal of heart failure, 2013, Volume: 15, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Aldosterone; Cardiac Catheterization; Cardiac Output, Low; Case-Cont

2013
Hypertension and increased aldosterone excretion associated with unilateral renal artery stenosis.
    Connecticut medicine, 1963, Volume: 27

    Topics: Aldosterone; Humans; Hyperparathyroidism; Hypertension; Hypertension, Pulmonary; Renal Artery Obstru

1963
Plasma volume and outcome in pulmonary hypertension.
    Texas Heart Institute journal, 2003, Volume: 30, Issue:4

    Topics: Adult; Aldosterone; Arginine Vasopressin; Atrial Natriuretic Factor; Catheterization, Swan-Ganz; Fea

2003
Haemodynamic and hormonal effects of captopril in primary pulmonary hypertension.
    British heart journal, 1982, Volume: 48, Issue:6

    Topics: Adult; Aged; Aldosterone; Angiotensin II; Blood Pressure; Captopril; Female; Hemodynamics; Humans; H

1982
[Role of the angiotensin-aldosterone mechanism in the formation of Pulmonogenic arterial hypertension].
    Klinicheskaia meditsina, 1982, Volume: 60, Issue:1

    Topics: Aldosterone; Angiotensin I; Angiotensins; Chronic Disease; Humans; Hypertension; Hypertension, Pulmo

1982
Atrial natriuretic factor in high-altitude pulmonary hypertension: the influence of acute hypoxia on plasma atrial natriuretic factor, renin, and aldosterone concentrations in highlanders with initially normal or elevated pulmonary artery pressure and wit
    Angiology, 1995, Volume: 46, Issue:9

    Topics: Acute Disease; Adolescent; Adult; Aldosterone; Altitude Sickness; Atrial Natriuretic Factor; Humans;

1995
Pulmonary hypertension. Response of vasoactive peptides to a nonionic contrast medium in patients undergoing pulmonary angiography.
    Investigative radiology, 1995, Volume: 30, Issue:9

    Topics: Adult; Aged; Aldosterone; Anaphylaxis; Angiography, Digital Subtraction; Angiotensin II; Atrial Natr

1995
[RAAS changes due to dysfunction of pulmonary ventilation].
    Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases, 1996, Volume: 19, Issue:2

    Topics: Aldosterone; Angiotensin II; Bronchitis; Female; Humans; Hypertension, Pulmonary; Lung Diseases, Obs

1996
[Activity of renin-angiotensin-aldosterone system (RAAS) and vasopressin level in patients with primary pulmonary hypertension].
    Terapevticheskii arkhiv, 1998, Volume: 70, Issue:4

    Topics: Adolescent; Adult; Aldosterone; Angiotensin II; Biomarkers; Female; Humans; Hypertension, Pulmonary;

1998
Plasma atrial natriuretic factor concentrations in a canine model of right heart pressure overload.
    Clinical and investigative medicine. Medecine clinique et experimentale, 1991, Volume: 14, Issue:4

    Topics: Aldosterone; Animals; Atrial Natriuretic Factor; Blood Pressure; Dogs; Edema; Heart Atria; Hypertens

1991
Atrial natriuretic factor in chronic obstructive lung disease with pulmonary hypertension. Physiological correlates and response to peptide infusion.
    The Journal of clinical investigation, 1989, Volume: 83, Issue:3

    Topics: Adult; Aged; Aldosterone; Atrial Natriuretic Factor; Blood Pressure; Cardiac Output; Female; Heart R

1989
Atrial natriuretic peptide lowers pulmonary arterial pressure in patients with high altitude disease.
    The American journal of the medical sciences, 1989, Volume: 298, Issue:6

    Topics: Aldosterone; Altitude Sickness; Atrial Natriuretic Factor; Hypertension, Pulmonary; Hypoxia; Renin

1989
[Hemodynamic changes and their relationship with the renin-angiotensin-aldosterone system in chronic obstructive pulmonary disease].
    Zhonghua yi xue za zhi, 1989, Volume: 69, Issue:6

    Topics: Aldosterone; Angiotensin II; Female; Hemodynamics; Humans; Hypertension, Pulmonary; Lung Diseases, O

1989
Prevalence and clinical peculiarities of essential hypertension in a population living at high altitude.
    Cor et vasa, 1985, Volume: 27, Issue:1

    Topics: Adult; Age Factors; Aldosterone; Alkalosis, Respiratory; Altitude; Altitude Sickness; Cardiomegaly;

1985
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