Page last updated: 2024-11-08

alanine and Glioma

alanine has been researched along with Glioma in 32 studies

Alanine: A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.
alanine : An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.

Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)

Research Excerpts

ExcerptRelevanceReference
"In gliomas a shift was found in the composition of enzymes, manifested by abnormal inhibition of pyruvate kinase by alanine."7.65Alanine inhibition of pyruvate kinase in gliomas and meningiomas. A diagnostic tool in surgery for gliomas? ( Staal, GE; van Veelen, CW; Verbiest, H; Vlug, AM, 1977)
"Gliotoxins are a group of amino acids that are toxic to astrocytes, and are substrates of high-affinity sodium-dependent glutamate transporters."5.32Gliotoxins disrupt alanine metabolism and glutathione production in C6 glioma cells: a 13C NMR spectroscopic study. ( Brennan, L; Hewage, C; Malthouse, JP; McBean, GJ, 2004)
"Serum alanine, alpha-aminobutyric acid (AABA), lysine (Lys) and cysteine concentrations were significantly higher in high-grade glioma patients despite low levels of alanine and Lys in the tumor tissue."4.31Tissue and plasma free amino acid detection by LC-MS/MS method in high grade glioma patients. ( Benli Aksungar, F; Gurses, MS; Kacira, T; Kemerdere, R; Tanriverdi, T; Toklu, S, 2023)
"In gliomas a shift was found in the composition of enzymes, manifested by abnormal inhibition of pyruvate kinase by alanine."3.65Alanine inhibition of pyruvate kinase in gliomas and meningiomas. A diagnostic tool in surgery for gliomas? ( Staal, GE; van Veelen, CW; Verbiest, H; Vlug, AM, 1977)
"Gliotoxins are a group of amino acids that are toxic to astrocytes, and are substrates of high-affinity sodium-dependent glutamate transporters."1.32Gliotoxins disrupt alanine metabolism and glutathione production in C6 glioma cells: a 13C NMR spectroscopic study. ( Brennan, L; Hewage, C; Malthouse, JP; McBean, GJ, 2004)
"High-grade brain tumors are known to have a high rate of glucose (Glc) consumption."1.31High glycolytic activity in rat glioma demonstrated in vivo by correlation peak 1H magnetic resonance imaging. ( Décorps, M; Rémy, C; von Kienlin , M; Ziegler, A, 2001)

Research

Studies (32)

TimeframeStudies, this research(%)All Research%
pre-199011 (34.38)18.7374
1990's5 (15.63)18.2507
2000's11 (34.38)29.6817
2010's3 (9.38)24.3611
2020's2 (6.25)2.80

Authors

AuthorsStudies
Toklu, S1
Kemerdere, R1
Kacira, T1
Gurses, MS1
Benli Aksungar, F1
Tanriverdi, T1
Viswanath, P1
Batsios, G1
Mukherjee, J1
Gillespie, AM1
Larson, PEZ1
Luchman, HA1
Phillips, JJ1
Costello, JF1
Pieper, RO1
Ronen, SM1
Sai, KK1
Huang, C2
Yuan, L2
Zhou, D1
Piwnica-Worms, D1
Garbow, JR1
Engelbach, JA1
Mach, RH1
Rich, KM1
McConathy, J2
Bartels, JL1
Li, A1
Rich, K1
Lapi, SE1
Li, J1
Shen, Y1
Liu, A1
Wang, X1
Zhao, C1
Younis, IR1
Elliott, M1
Peer, CJ1
Cooper, AJ1
Pinto, JT1
Konat, GW1
Kraszpulski, M1
Petros, WP1
Callery, PS1
Berges, R1
Balzeau, J1
Takahashi, M1
Prevost, C1
Eyer, J1
Madhankumar, AB1
Mintz, A1
Debinski, W1
Bulakbasi, N1
Kocaoglu, M1
Ors, F1
Tayfun, C1
Uçöz, T1
Deitmer, JW1
Bröer, A1
Bröer, S1
Brennan, L1
Hewage, C1
Malthouse, JP1
McBean, GJ1
McKnight, TR1
Schulz, I1
Zeitschel, U1
Rudolph, T1
Ruiz-Carrillo, D1
Rahfeld, JU1
Gerhartz, B1
Bigl, V1
Demuth, HU1
Rossner, S1
Pfeuffer, J1
Lin, JC1
Delabarre, L1
Ugurbil, K1
Garwood, M1
van Veelen, CW6
Verbiest, H5
Zülch, KJ3
van Ketel, B2
van der Vlist, MJ3
Vlug, AM6
Rijksen, G5
Staal, GE6
Lee, RK1
Wurtman, RJ1
Cox, AJ1
Nitsch, RM1
Portais, JC1
Schuster, R1
Merle, M2
Canioni, P2
Bouzier, AK1
Quesson, B1
Valeins, H1
Ziegler, A1
von Kienlin , M1
Décorps, M1
Rémy, C1
Auer, DP1
Gössl, C1
Schirmer, T1
Czisch, M1
van Ketel, BA1
Bauer, K1
Salnikow, J1
de Vitry, F1
Tixier-Vidal, A1
Kleinkauf, H1
Martin, DL1
Shain, W1
Sieghart, W1
Karobath, M1
Cox, BA1
Henningsen, RA1
Spanoyannis, A1
Neve, RL1
Neve, KA1
Lomneth, R1
Medrano, S1
Gruenstein, EI1
Schrier, BK1
Thompson, EJ1
Brecher, AS1
Pugatch, RD1
König, M1
Wasilauskas, VP1
Suszkiw, JB1
Sobel, RE1

Reviews

1 review available for alanine and Glioma

ArticleYear
Proton magnetic resonance spectroscopic evaluation of brain tumor metabolism.
    Seminars in oncology, 2004, Volume: 31, Issue:5

    Topics: Alanine; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Glioma; Glutamic Acid; Glutamine; Humans

2004

Other Studies

31 other studies available for alanine and Glioma

ArticleYear
Tissue and plasma free amino acid detection by LC-MS/MS method in high grade glioma patients.
    Journal of neuro-oncology, 2023, Volume: 163, Issue:2

    Topics: Alanine; Amines; Amino Acids; Chromatography, Liquid; Glioma; Humans; Prospective Studies; Tandem Ma

2023
Non-invasive assessment of telomere maintenance mechanisms in brain tumors.
    Nature communications, 2021, 01-04, Volume: 12, Issue:1

    Topics: Alanine; Animals; Biomarkers, Tumor; Brain Neoplasms; Carbon Isotopes; Cell Line, Tumor; Genetic Eng

2021
18F-AFETP, 18F-FET, and 18F-FDG imaging of mouse DBT gliomas.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2013, Volume: 54, Issue:7

    Topics: Alanine; Animals; Brain Neoplasms; Cell Line, Tumor; Fluorodeoxyglucose F18; Glioma; Male; Metabolic

2013
Synthesis and Biological Evaluation of (S)-Amino-2-methyl-4-[(76)Br]bromo-3-(E)-butenoic Acid (BrVAIB) for Brain Tumor Imaging.
    Journal of medicinal chemistry, 2015, 11-12, Volume: 58, Issue:21

    Topics: Alanine; Amination; Animals; Biological Transport; Brain; Brain Neoplasms; Bromine Radioisotopes; Cr

2015
Transfection of the DAAO gene and subsequent induction of cytotoxic oxidative stress by D-alanine in 9L cells.
    Oncology reports, 2008, Volume: 20, Issue:2

    Topics: Alanine; Animals; Apoptosis; Blotting, Western; Brain Neoplasms; Breast Neoplasms; Carcinoma, Squamo

2008
Dehydroalanine analog of glutathione: an electrophilic busulfan metabolite that binds to human glutathione S-transferase A1-1.
    The Journal of pharmacology and experimental therapeutics, 2008, Volume: 327, Issue:3

    Topics: Alanine; Animals; Antineoplastic Agents, Alkylating; Busulfan; Cell Line, Tumor; Glioma; Glutathione

2008
Structure-function analysis of the glioma targeting NFL-TBS.40-63 peptide corresponding to the tubulin-binding site on the light neurofilament subunit.
    PloS one, 2012, Volume: 7, Issue:11

    Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Binding Sites; Brain Neoplasms; Cell Line, Tu

2012
Alanine-scanning mutagenesis of alpha-helix D segment of interleukin-13 reveals new functionally important residues of the cytokine.
    The Journal of biological chemistry, 2002, Nov-08, Volume: 277, Issue:45

    Topics: Alanine; Amino Acid Sequence; Base Sequence; Binding Sites; Cell Survival; Circular Dichroism; Cloni

2002
Combination of single-voxel proton MR spectroscopy and apparent diffusion coefficient calculation in the evaluation of common brain tumors.
    AJNR. American journal of neuroradiology, 2003, Volume: 24, Issue:2

    Topics: Adolescent; Adult; Aged; Alanine; Aspartic Acid; Astrocytoma; Brain; Brain Neoplasms; Choline; Creat

2003
Glutamine efflux from astrocytes is mediated by multiple pathways.
    Journal of neurochemistry, 2003, Volume: 87, Issue:1

    Topics: Alanine; Amino Acid Transport System ASC; Amino Acid Transport System y+; Amino Acid Transport Syste

2003
Gliotoxins disrupt alanine metabolism and glutathione production in C6 glioma cells: a 13C NMR spectroscopic study.
    Neurochemistry international, 2004, Volume: 45, Issue:8

    Topics: Alanine; Alanine Transaminase; Brain Neoplasms; Cell Line, Tumor; Dicarboxylic Acids; Enzyme Inhibit

2004
Subcellular localization suggests novel functions for prolyl endopeptidase in protein secretion.
    Journal of neurochemistry, 2005, Volume: 94, Issue:4

    Topics: Alanine; Cell Line, Tumor; Fluoresceins; Glioma; Green Fluorescent Proteins; Humans; Immunohistochem

2005
Detection of intracellular lactate with localized diffusion {1H-13C}-spectroscopy in rat glioma in vivo.
    Journal of magnetic resonance (San Diego, Calif. : 1997), 2005, Volume: 177, Issue:1

    Topics: Alanine; Animals; Brain; Brain Neoplasms; Glioma; Lactates; Magnetic Resonance Spectroscopy; Male; R

2005
Pyruvate kinase in human brain tumours. Its significance in the treatment of gliomas.
    Acta neurochirurgica, 1982, Volume: 61, Issue:1-3

    Topics: Adolescent; Adult; Aged; Alanine; Brain; Brain Neoplasms; Cell Transformation, Neoplastic; Child; Ch

1982
Correlation between alanine inhibition of pyruvate and composition of K-M hybrids.
    Clinica chimica acta; international journal of clinical chemistry, 1981, Feb-19, Volume: 110, Issue:1

    Topics: Alanine; Brain; Brain Neoplasms; Glioma; Humans; Isoenzymes; Kidney; Kinetics; Macromolecular Substa

1981
[Pyruvate kinase as a marker of human brain tumors].
    Nederlands tijdschrift voor geneeskunde, 1980, Oct-04, Volume: 124, Issue:40

    Topics: Adolescent; Adult; Aged; Alanine; Astrocytoma; Brain; Brain Neoplasms; Child; Child, Preschool; Fema

1980
Amyloid precursor protein processing is stimulated by metabotropic glutamate receptors.
    Proceedings of the National Academy of Sciences of the United States of America, 1995, Aug-15, Volume: 92, Issue:17

    Topics: Alanine; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Cell Line; Chelating Agents

1995
Metabolic flux determination in C6 glioma cells using carbon-13 distribution upon [1-13C]glucose incubation.
    European journal of biochemistry, 1993, Oct-01, Volume: 217, Issue:1

    Topics: Alanine; Aspartic Acid; Carbon Isotopes; Citric Acid Cycle; Glioma; Gluconeogenesis; Glucose; Glutam

1993
[1-(13)C]glucose metabolism in the tumoral and nontumoral cerebral tissue of a glioma-bearing rat.
    Journal of neurochemistry, 1999, Volume: 72, Issue:6

    Topics: Alanine; Amino Acids; Analysis of Variance; Animals; Aspartic Acid; Body Weight; Brain; Brain Neopla

1999
High glycolytic activity in rat glioma demonstrated in vivo by correlation peak 1H magnetic resonance imaging.
    Cancer research, 2001, Jul-15, Volume: 61, Issue:14

    Topics: Alanine; Animals; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Ethanolamines; Female; Glioma;

2001
Improved analysis of 1H-MR spectra in the presence of mobile lipids.
    Magnetic resonance in medicine, 2001, Volume: 46, Issue:3

    Topics: Alanine; Artifacts; Brain; Brain Diseases; Brain Neoplasms; Glioblastoma; Glioma; Humans; Image Enha

2001
Alanine inhibition of pyruvate kinase in gliomas and meningiomas. A diagnostic tool in surgery for gliomas?
    Lancet (London, England), 1977, Aug-20, Volume: 2, Issue:8034

    Topics: Alanine; Brain Neoplasms; Glioma; Humans; Isoenzymes; Meningioma; Pyruvate Kinase

1977
Isozymes of pyruvate kinase from human brain, meningiomas, and malignant gliomas.
    Cancer research, 1978, Volume: 38, Issue:12

    Topics: Alanine; Brain; Brain Neoplasms; Fetus; Glioblastoma; Glioma; Humans; Infant, Newborn; Isoenzymes; K

1978
L-alpha-alanine inhibition of pyruvate kinase from tumors of the human central nervous system.
    Cancer research, 1979, Volume: 39, Issue:10

    Topics: Adult; Alanine; Astrocytoma; Brain Neoplasms; Child; Child, Preschool; Glioblastoma; Glioma; Humans;

1979
Characterization and biosynthesis of omega-aminoacyl amino acids from rat brain and the C-6 glioma cell line.
    The Journal of biological chemistry, 1979, Jul-25, Volume: 254, Issue:14

    Topics: Alanine; Aminobutyrates; Animals; Brain; Carnosine; Cell Line; Dipeptides; Glioma; Ornithine; Peptid

1979
High affinity transport of taurine and beta-alanine and low affinity transport of gamma-aminobutyric acid by a single transport system in cultured glioma cells.
    The Journal of biological chemistry, 1979, Aug-10, Volume: 254, Issue:15

    Topics: Alanine; Animals; Biological Transport; Cell Line; gamma-Aminobutyric Acid; Glioma; Kinetics; Rats;

1979
Uptake of taurine into subcellular fractions of C-6 glioma cells.
    Journal of neurochemistry, 1976, Volume: 26, Issue:5

    Topics: Alanine; Animals; Biological Transport, Active; Cell Line; Cerebral Cortex; Cyanides; Dinitrophenols

1976
Contributions of conserved serine residues to the interactions of ligands with dopamine D2 receptors.
    Journal of neurochemistry, 1992, Volume: 59, Issue:2

    Topics: Adenylyl Cyclase Inhibitors; Alanine; Animals; Base Sequence; Benzamides; Cell Line; Glioma; Immunob

1992
The role of transmembrane pH gradients in the lactic acid induced swelling of astrocytes.
    Brain research, 1990, Jul-16, Volume: 523, Issue:1

    Topics: Alanine; Astrocytes; Brain Neoplasms; Cell Membrane; Dimethadione; Glioma; Humans; Hydrogen-Ion Conc

1990
On the role of glial cells in the mammalian nervous system. Uptake, excretion, and metabolism of putative neurotransmitters by cultured glial tumor cells.
    The Journal of biological chemistry, 1974, Mar-25, Volume: 249, Issue:6

    Topics: Alanine; Alkaloids; Alkanesulfonates; Amino Acids; Aminobutyrates; Animals; Brain; Carbon Dioxide; C

1974
The hydrolytic activity in normal human and malignant tissue.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1969, Volume: 131, Issue:3

    Topics: Acid Phosphatase; Adenocarcinoma, Papillary; Alanine; Alkaline Phosphatase; Amides; Amidohydrolases;

1969