alanine has been researched along with Glioma in 32 studies
Alanine: A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.
alanine : An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.
Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
| Excerpt | Relevance | Reference |
|---|---|---|
| "In gliomas a shift was found in the composition of enzymes, manifested by abnormal inhibition of pyruvate kinase by alanine." | 7.65 | Alanine inhibition of pyruvate kinase in gliomas and meningiomas. A diagnostic tool in surgery for gliomas? ( Staal, GE; van Veelen, CW; Verbiest, H; Vlug, AM, 1977) |
| "Gliotoxins are a group of amino acids that are toxic to astrocytes, and are substrates of high-affinity sodium-dependent glutamate transporters." | 5.32 | Gliotoxins disrupt alanine metabolism and glutathione production in C6 glioma cells: a 13C NMR spectroscopic study. ( Brennan, L; Hewage, C; Malthouse, JP; McBean, GJ, 2004) |
| "Serum alanine, alpha-aminobutyric acid (AABA), lysine (Lys) and cysteine concentrations were significantly higher in high-grade glioma patients despite low levels of alanine and Lys in the tumor tissue." | 4.31 | Tissue and plasma free amino acid detection by LC-MS/MS method in high grade glioma patients. ( Benli Aksungar, F; Gurses, MS; Kacira, T; Kemerdere, R; Tanriverdi, T; Toklu, S, 2023) |
| "In gliomas a shift was found in the composition of enzymes, manifested by abnormal inhibition of pyruvate kinase by alanine." | 3.65 | Alanine inhibition of pyruvate kinase in gliomas and meningiomas. A diagnostic tool in surgery for gliomas? ( Staal, GE; van Veelen, CW; Verbiest, H; Vlug, AM, 1977) |
| "Gliotoxins are a group of amino acids that are toxic to astrocytes, and are substrates of high-affinity sodium-dependent glutamate transporters." | 1.32 | Gliotoxins disrupt alanine metabolism and glutathione production in C6 glioma cells: a 13C NMR spectroscopic study. ( Brennan, L; Hewage, C; Malthouse, JP; McBean, GJ, 2004) |
| "High-grade brain tumors are known to have a high rate of glucose (Glc) consumption." | 1.31 | High glycolytic activity in rat glioma demonstrated in vivo by correlation peak 1H magnetic resonance imaging. ( Décorps, M; Rémy, C; von Kienlin , M; Ziegler, A, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (34.38) | 18.7374 |
| 1990's | 5 (15.63) | 18.2507 |
| 2000's | 11 (34.38) | 29.6817 |
| 2010's | 3 (9.38) | 24.3611 |
| 2020's | 2 (6.25) | 2.80 |
| Authors | Studies |
|---|---|
| Toklu, S | 1 |
| Kemerdere, R | 1 |
| Kacira, T | 1 |
| Gurses, MS | 1 |
| Benli Aksungar, F | 1 |
| Tanriverdi, T | 1 |
| Viswanath, P | 1 |
| Batsios, G | 1 |
| Mukherjee, J | 1 |
| Gillespie, AM | 1 |
| Larson, PEZ | 1 |
| Luchman, HA | 1 |
| Phillips, JJ | 1 |
| Costello, JF | 1 |
| Pieper, RO | 1 |
| Ronen, SM | 1 |
| Sai, KK | 1 |
| Huang, C | 2 |
| Yuan, L | 2 |
| Zhou, D | 1 |
| Piwnica-Worms, D | 1 |
| Garbow, JR | 1 |
| Engelbach, JA | 1 |
| Mach, RH | 1 |
| Rich, KM | 1 |
| McConathy, J | 2 |
| Bartels, JL | 1 |
| Li, A | 1 |
| Rich, K | 1 |
| Lapi, SE | 1 |
| Li, J | 1 |
| Shen, Y | 1 |
| Liu, A | 1 |
| Wang, X | 1 |
| Zhao, C | 1 |
| Younis, IR | 1 |
| Elliott, M | 1 |
| Peer, CJ | 1 |
| Cooper, AJ | 1 |
| Pinto, JT | 1 |
| Konat, GW | 1 |
| Kraszpulski, M | 1 |
| Petros, WP | 1 |
| Callery, PS | 1 |
| Berges, R | 1 |
| Balzeau, J | 1 |
| Takahashi, M | 1 |
| Prevost, C | 1 |
| Eyer, J | 1 |
| Madhankumar, AB | 1 |
| Mintz, A | 1 |
| Debinski, W | 1 |
| Bulakbasi, N | 1 |
| Kocaoglu, M | 1 |
| Ors, F | 1 |
| Tayfun, C | 1 |
| Uçöz, T | 1 |
| Deitmer, JW | 1 |
| Bröer, A | 1 |
| Bröer, S | 1 |
| Brennan, L | 1 |
| Hewage, C | 1 |
| Malthouse, JP | 1 |
| McBean, GJ | 1 |
| McKnight, TR | 1 |
| Schulz, I | 1 |
| Zeitschel, U | 1 |
| Rudolph, T | 1 |
| Ruiz-Carrillo, D | 1 |
| Rahfeld, JU | 1 |
| Gerhartz, B | 1 |
| Bigl, V | 1 |
| Demuth, HU | 1 |
| Rossner, S | 1 |
| Pfeuffer, J | 1 |
| Lin, JC | 1 |
| Delabarre, L | 1 |
| Ugurbil, K | 1 |
| Garwood, M | 1 |
| van Veelen, CW | 6 |
| Verbiest, H | 5 |
| Zülch, KJ | 3 |
| van Ketel, B | 2 |
| van der Vlist, MJ | 3 |
| Vlug, AM | 6 |
| Rijksen, G | 5 |
| Staal, GE | 6 |
| Lee, RK | 1 |
| Wurtman, RJ | 1 |
| Cox, AJ | 1 |
| Nitsch, RM | 1 |
| Portais, JC | 1 |
| Schuster, R | 1 |
| Merle, M | 2 |
| Canioni, P | 2 |
| Bouzier, AK | 1 |
| Quesson, B | 1 |
| Valeins, H | 1 |
| Ziegler, A | 1 |
| von Kienlin , M | 1 |
| Décorps, M | 1 |
| Rémy, C | 1 |
| Auer, DP | 1 |
| Gössl, C | 1 |
| Schirmer, T | 1 |
| Czisch, M | 1 |
| van Ketel, BA | 1 |
| Bauer, K | 1 |
| Salnikow, J | 1 |
| de Vitry, F | 1 |
| Tixier-Vidal, A | 1 |
| Kleinkauf, H | 1 |
| Martin, DL | 1 |
| Shain, W | 1 |
| Sieghart, W | 1 |
| Karobath, M | 1 |
| Cox, BA | 1 |
| Henningsen, RA | 1 |
| Spanoyannis, A | 1 |
| Neve, RL | 1 |
| Neve, KA | 1 |
| Lomneth, R | 1 |
| Medrano, S | 1 |
| Gruenstein, EI | 1 |
| Schrier, BK | 1 |
| Thompson, EJ | 1 |
| Brecher, AS | 1 |
| Pugatch, RD | 1 |
| König, M | 1 |
| Wasilauskas, VP | 1 |
| Suszkiw, JB | 1 |
| Sobel, RE | 1 |
1 review available for alanine and Glioma
| Article | Year |
|---|---|
Proton magnetic resonance spectroscopic evaluation of brain tumor metabolism.
Topics: Alanine; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Glioma; Glutamic Acid; Glutamine; Humans | 2004 |
31 other studies available for alanine and Glioma
| Article | Year |
|---|---|
Tissue and plasma free amino acid detection by LC-MS/MS method in high grade glioma patients.
Topics: Alanine; Amines; Amino Acids; Chromatography, Liquid; Glioma; Humans; Prospective Studies; Tandem Ma | 2023 |
Non-invasive assessment of telomere maintenance mechanisms in brain tumors.
Topics: Alanine; Animals; Biomarkers, Tumor; Brain Neoplasms; Carbon Isotopes; Cell Line, Tumor; Genetic Eng | 2021 |
18F-AFETP, 18F-FET, and 18F-FDG imaging of mouse DBT gliomas.
Topics: Alanine; Animals; Brain Neoplasms; Cell Line, Tumor; Fluorodeoxyglucose F18; Glioma; Male; Metabolic | 2013 |
Synthesis and Biological Evaluation of (S)-Amino-2-methyl-4-[(76)Br]bromo-3-(E)-butenoic Acid (BrVAIB) for Brain Tumor Imaging.
Topics: Alanine; Amination; Animals; Biological Transport; Brain; Brain Neoplasms; Bromine Radioisotopes; Cr | 2015 |
Transfection of the DAAO gene and subsequent induction of cytotoxic oxidative stress by D-alanine in 9L cells.
Topics: Alanine; Animals; Apoptosis; Blotting, Western; Brain Neoplasms; Breast Neoplasms; Carcinoma, Squamo | 2008 |
Dehydroalanine analog of glutathione: an electrophilic busulfan metabolite that binds to human glutathione S-transferase A1-1.
Topics: Alanine; Animals; Antineoplastic Agents, Alkylating; Busulfan; Cell Line, Tumor; Glioma; Glutathione | 2008 |
Structure-function analysis of the glioma targeting NFL-TBS.40-63 peptide corresponding to the tubulin-binding site on the light neurofilament subunit.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Binding Sites; Brain Neoplasms; Cell Line, Tu | 2012 |
Alanine-scanning mutagenesis of alpha-helix D segment of interleukin-13 reveals new functionally important residues of the cytokine.
Topics: Alanine; Amino Acid Sequence; Base Sequence; Binding Sites; Cell Survival; Circular Dichroism; Cloni | 2002 |
Combination of single-voxel proton MR spectroscopy and apparent diffusion coefficient calculation in the evaluation of common brain tumors.
Topics: Adolescent; Adult; Aged; Alanine; Aspartic Acid; Astrocytoma; Brain; Brain Neoplasms; Choline; Creat | 2003 |
Glutamine efflux from astrocytes is mediated by multiple pathways.
Topics: Alanine; Amino Acid Transport System ASC; Amino Acid Transport System y+; Amino Acid Transport Syste | 2003 |
Gliotoxins disrupt alanine metabolism and glutathione production in C6 glioma cells: a 13C NMR spectroscopic study.
Topics: Alanine; Alanine Transaminase; Brain Neoplasms; Cell Line, Tumor; Dicarboxylic Acids; Enzyme Inhibit | 2004 |
Subcellular localization suggests novel functions for prolyl endopeptidase in protein secretion.
Topics: Alanine; Cell Line, Tumor; Fluoresceins; Glioma; Green Fluorescent Proteins; Humans; Immunohistochem | 2005 |
Detection of intracellular lactate with localized diffusion {1H-13C}-spectroscopy in rat glioma in vivo.
Topics: Alanine; Animals; Brain; Brain Neoplasms; Glioma; Lactates; Magnetic Resonance Spectroscopy; Male; R | 2005 |
Pyruvate kinase in human brain tumours. Its significance in the treatment of gliomas.
Topics: Adolescent; Adult; Aged; Alanine; Brain; Brain Neoplasms; Cell Transformation, Neoplastic; Child; Ch | 1982 |
Correlation between alanine inhibition of pyruvate and composition of K-M hybrids.
Topics: Alanine; Brain; Brain Neoplasms; Glioma; Humans; Isoenzymes; Kidney; Kinetics; Macromolecular Substa | 1981 |
[Pyruvate kinase as a marker of human brain tumors].
Topics: Adolescent; Adult; Aged; Alanine; Astrocytoma; Brain; Brain Neoplasms; Child; Child, Preschool; Fema | 1980 |
Amyloid precursor protein processing is stimulated by metabotropic glutamate receptors.
Topics: Alanine; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Cell Line; Chelating Agents | 1995 |
Metabolic flux determination in C6 glioma cells using carbon-13 distribution upon [1-13C]glucose incubation.
Topics: Alanine; Aspartic Acid; Carbon Isotopes; Citric Acid Cycle; Glioma; Gluconeogenesis; Glucose; Glutam | 1993 |
[1-(13)C]glucose metabolism in the tumoral and nontumoral cerebral tissue of a glioma-bearing rat.
Topics: Alanine; Amino Acids; Analysis of Variance; Animals; Aspartic Acid; Body Weight; Brain; Brain Neopla | 1999 |
High glycolytic activity in rat glioma demonstrated in vivo by correlation peak 1H magnetic resonance imaging.
Topics: Alanine; Animals; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Ethanolamines; Female; Glioma; | 2001 |
Improved analysis of 1H-MR spectra in the presence of mobile lipids.
Topics: Alanine; Artifacts; Brain; Brain Diseases; Brain Neoplasms; Glioblastoma; Glioma; Humans; Image Enha | 2001 |
Alanine inhibition of pyruvate kinase in gliomas and meningiomas. A diagnostic tool in surgery for gliomas?
Topics: Alanine; Brain Neoplasms; Glioma; Humans; Isoenzymes; Meningioma; Pyruvate Kinase | 1977 |
Isozymes of pyruvate kinase from human brain, meningiomas, and malignant gliomas.
Topics: Alanine; Brain; Brain Neoplasms; Fetus; Glioblastoma; Glioma; Humans; Infant, Newborn; Isoenzymes; K | 1978 |
L-alpha-alanine inhibition of pyruvate kinase from tumors of the human central nervous system.
Topics: Adult; Alanine; Astrocytoma; Brain Neoplasms; Child; Child, Preschool; Glioblastoma; Glioma; Humans; | 1979 |
Characterization and biosynthesis of omega-aminoacyl amino acids from rat brain and the C-6 glioma cell line.
Topics: Alanine; Aminobutyrates; Animals; Brain; Carnosine; Cell Line; Dipeptides; Glioma; Ornithine; Peptid | 1979 |
High affinity transport of taurine and beta-alanine and low affinity transport of gamma-aminobutyric acid by a single transport system in cultured glioma cells.
Topics: Alanine; Animals; Biological Transport; Cell Line; gamma-Aminobutyric Acid; Glioma; Kinetics; Rats; | 1979 |
Uptake of taurine into subcellular fractions of C-6 glioma cells.
Topics: Alanine; Animals; Biological Transport, Active; Cell Line; Cerebral Cortex; Cyanides; Dinitrophenols | 1976 |
Contributions of conserved serine residues to the interactions of ligands with dopamine D2 receptors.
Topics: Adenylyl Cyclase Inhibitors; Alanine; Animals; Base Sequence; Benzamides; Cell Line; Glioma; Immunob | 1992 |
The role of transmembrane pH gradients in the lactic acid induced swelling of astrocytes.
Topics: Alanine; Astrocytes; Brain Neoplasms; Cell Membrane; Dimethadione; Glioma; Humans; Hydrogen-Ion Conc | 1990 |
On the role of glial cells in the mammalian nervous system. Uptake, excretion, and metabolism of putative neurotransmitters by cultured glial tumor cells.
Topics: Alanine; Alkaloids; Alkanesulfonates; Amino Acids; Aminobutyrates; Animals; Brain; Carbon Dioxide; C | 1974 |
The hydrolytic activity in normal human and malignant tissue.
Topics: Acid Phosphatase; Adenocarcinoma, Papillary; Alanine; Alkaline Phosphatase; Amides; Amidohydrolases; | 1969 |