Page last updated: 2024-11-08

alanine and Ache

alanine has been researched along with Ache in 24 studies

Alanine: A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.
alanine : An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.

Research Excerpts

ExcerptRelevanceReference
"The non-dopaminergic and dopaminergic actions of safinamide may alleviate pain in patients with Parkinson's disease (PD)."9.41Effects of safinamide adjunct therapy on pain in patients with Parkinson's disease: Post hoc analysis of a Japanese phase 2/3 study. ( Hattori, N; Ishida, T; Koebis, M; Kogo, Y; Nomoto, M; Suzuki, I; Tsuboi, Y, 2021)
"To investigate the effects of safinamide on pain management in PD patients with motor fluctuations using pooled data from studies 016 and SETTLE."9.24Effects of Safinamide on Pain in Fluctuating Parkinson's Disease Patients: A Post-Hoc Analysis. ( Barone, P; Bonizzoni, E; Cattaneo, C; Sardina, M, 2017)
"Safinamide seems to be an effective adjunctive treatment in PD patients treated with bilateral STN-DBS, leading to an improvement of motor complications, mood and pain."8.12Efficacy of safinamide as add-on therapy after subthalamic nucleus deep brain stimulation in Parkinson disease. ( Artusi, CA; Balestrino, R; Bonvegna, S; Fabbri, M; Imbalzano, G; Lopiano, L; Mancini, F; Montanaro, E; Rizzone, MG; Romagnolo, A; Zibetti, M, 2022)
"Our results suggest that safinamide may have a beneficial effect on pain, a key unmet need in fluctuating PD patients."8.02Effects of safinamide on pain in patients with fluctuating Parkinson's disease. ( Falkenburger, B; Grigoriou, S; Hausbrand, D; Leta, V; Martínez-Martín, P; Odin, P; Ray Chaudhuri, K; Reichmann, H; Rukavina, K, 2021)
"The effects of the specific 5-HT uptake inhibitors alaproclate and zimelidine, the 5-HT releasing compound p-chloroamphetamine (PCA) and the specific NA uptake inhibitor desipramine on pain sensitivity were examined in male rats using the hot-plate and tail-flick methods."7.66Test-specific effects of the 5-HT reuptake inhibitors alaproclate and zimelidine on pain sensitivity and morphine analgesia. ( Holm, AC; Ogren, SO, 1980)
"Pain is a common and disabling non-motor symptom (NMS) of Parkinson's disease (PD), which occurs through the course of the disease, often unrecognized and undertreated."5.56Effects of safinamide on pain in Parkinson's disease with motor fluctuations: an exploratory study. ( Bovi, T; Di Vico, IA; Geroin, C; Segatti, A; Squintani, G; Tinazzi, M, 2020)
"The non-dopaminergic and dopaminergic actions of safinamide may alleviate pain in patients with Parkinson's disease (PD)."5.41Effects of safinamide adjunct therapy on pain in patients with Parkinson's disease: Post hoc analysis of a Japanese phase 2/3 study. ( Hattori, N; Ishida, T; Koebis, M; Kogo, Y; Nomoto, M; Suzuki, I; Tsuboi, Y, 2021)
"To investigate the effects of safinamide on pain management in PD patients with motor fluctuations using pooled data from studies 016 and SETTLE."5.24Effects of Safinamide on Pain in Fluctuating Parkinson's Disease Patients: A Post-Hoc Analysis. ( Barone, P; Bonizzoni, E; Cattaneo, C; Sardina, M, 2017)
"Treatment with levodopa increases pain thresholds in patients with PD."5.05Current Status of Pain Management in Parkinson's Disease. ( Bruno, V; Farcy, N; Karnik, V; Zamorano, C, 2020)
"Safinamide seems to be an effective adjunctive treatment in PD patients treated with bilateral STN-DBS, leading to an improvement of motor complications, mood and pain."4.12Efficacy of safinamide as add-on therapy after subthalamic nucleus deep brain stimulation in Parkinson disease. ( Artusi, CA; Balestrino, R; Bonvegna, S; Fabbri, M; Imbalzano, G; Lopiano, L; Mancini, F; Montanaro, E; Rizzone, MG; Romagnolo, A; Zibetti, M, 2022)
"Our results suggest that safinamide may have a beneficial effect on pain, a key unmet need in fluctuating PD patients."4.02Effects of safinamide on pain in patients with fluctuating Parkinson's disease. ( Falkenburger, B; Grigoriou, S; Hausbrand, D; Leta, V; Martínez-Martín, P; Odin, P; Ray Chaudhuri, K; Reichmann, H; Rukavina, K, 2021)
" In rats with hindpaw inflammation, inhibitors of aminopeptidase N (APN; bestatin) or neutral endopeptidase (NEP; thiorphan), and a dual inhibitor, NH(2)-CH-Ph-P(O)(OH)CH(2)-CH-CH(2)Ph(p-Ph)-CONH-CH-CH(3)-COOH (P8B), were applied to injured paws."3.78Pain inhibition by blocking leukocytic and neuronal opioid peptidases in peripheral inflamed tissue. ( Fournie-Zaluski, MC; Gore, C; Labuz, D; Machelska, H; Roques, BP; Schreiter, A; Stein, C, 2012)
" We show that the conjugate of arachidonic acid and glycine (N-arachidonylglycine (NAGly)) is present in bovine and rat brain as well as other tissues and that it suppresses tonic inflammatory pain."3.71Identification of a new class of molecules, the arachidonyl amino acids, and characterization of one member that inhibits pain. ( Bisogno, T; Burstein, S; Chang, SY; Coop, A; De Petrocellis, L; Di Marzo, V; Huang, SM; Maeda, DY; Petros, TJ; Sivakumar, R; Walker, JM; Zavitsanos, PA; Zipkin, RE, 2001)
"The NMDA receptor and the NK-1 receptor are important determinants of the MAC of isoflurane, exerting this influence by inhibition of pain transmission in the spinal cord, while mGlu and AMPA receptors have no effect on the MAC of isoflurane."3.70Intrathecal co-administration of NMDA antagonist and NK-1 antagonist reduces MAC of isoflurane in rats. ( Goto, F; Ishizaki, K; Karasawa, S; Nara, T; Obata, H; Sasaki, M, 1999)
"The effects of the specific 5-HT uptake inhibitors alaproclate and zimelidine, the 5-HT releasing compound p-chloroamphetamine (PCA) and the specific NA uptake inhibitor desipramine on pain sensitivity were examined in male rats using the hot-plate and tail-flick methods."3.66Test-specific effects of the 5-HT reuptake inhibitors alaproclate and zimelidine on pain sensitivity and morphine analgesia. ( Holm, AC; Ogren, SO, 1980)
"Safinamide is an important adjunct to standard parkinsonian medication for alleviating pain in PD."2.58Comprehensive Examination of Therapies for Pain in Parkinson's Disease: A Systematic Review and Meta-Analysis. ( Akhter, S; Malik, SH; Qureshi, AR; Rana, AQ; Rana, R; Rizvi, SFH; Sarfraz, Z; Vannabouathong, C, 2018)
"Neonatal pain is often undertreated."2.50[Maybe it hurts more than we think! Neonatal pain]. ( Mikos, B, 2014)
"Pain is a common and disabling non-motor symptom (NMS) of Parkinson's disease (PD), which occurs through the course of the disease, often unrecognized and undertreated."1.56Effects of safinamide on pain in Parkinson's disease with motor fluctuations: an exploratory study. ( Bovi, T; Di Vico, IA; Geroin, C; Segatti, A; Squintani, G; Tinazzi, M, 2020)
"Strychnine induced two types of motor seizures: (1) falling over with tail whipping and (2) convulsions."1.27Prevention of the convulsant and hyperalgesic action of strychnine by intrathecal glycine and related amino acids. ( Banas, C; Beyer, C; Gomora, P; Komisaruk, BR, 1988)

Research

Studies (24)

TimeframeStudies, this research(%)All Research%
pre-19903 (12.50)18.7374
1990's4 (16.67)18.2507
2000's4 (16.67)29.6817
2010's7 (29.17)24.3611
2020's6 (25.00)2.80

Authors

AuthorsStudies
Grigoriou, S1
Martínez-Martín, P1
Ray Chaudhuri, K1
Rukavina, K1
Leta, V1
Hausbrand, D1
Falkenburger, B1
Odin, P1
Reichmann, H1
Tsuboi, Y1
Koebis, M1
Kogo, Y1
Ishida, T1
Suzuki, I1
Nomoto, M1
Hattori, N1
Rizzone, MG1
Mancini, F1
Artusi, CA1
Balestrino, R1
Bonvegna, S1
Fabbri, M1
Imbalzano, G1
Montanaro, E1
Romagnolo, A1
Zibetti, M1
Lopiano, L1
De Masi, C1
Liguori, C1
Spanetta, M1
Fernandes, M1
Cerroni, R1
Garasto, E1
Pierantozzi, M1
Mercuri, NB1
Stefani, A1
Karnik, V1
Farcy, N1
Zamorano, C1
Bruno, V1
Geroin, C1
Di Vico, IA1
Squintani, G1
Segatti, A1
Bovi, T1
Tinazzi, M1
Qureshi, AR1
Rana, AQ1
Malik, SH1
Rizvi, SFH1
Akhter, S1
Vannabouathong, C1
Sarfraz, Z1
Rana, R1
Mikos, B1
Cattaneo, C1
Barone, P1
Bonizzoni, E1
Sardina, M1
Salomé, C1
Salomé-Grosjean, E1
Stables, JP1
Kohn, H1
Moon, SJ2
Woo, YJ1
Jeong, JH2
Park, MK2
Oh, HJ1
Park, JS2
Kim, EK2
Cho, ML2
Park, SH2
Kim, HY2
Min, JK2
Schreiter, A1
Gore, C1
Labuz, D1
Fournie-Zaluski, MC2
Roques, BP2
Stein, C1
Machelska, H1
Yang, EJ1
Li, W1
Neugebauer, V2
Yoshimura, M1
Yonehara, N1
Liu, T1
Pang, XY1
Bai, ZT1
Chai, ZF1
Jiang, F1
Ji, YH1
Ogren, SO1
Holm, AC1
Cuthbertson, DP1
Lücke, T1
Schaible, HG1
Young, MR1
Fleetwood-Walker, SM1
Dickinson, T1
Blackburn-Munro, G1
Sparrow, H1
Birch, PJ1
Bountra, C1
Noble, F1
Smadja, C1
Valverde, O1
Maldonado, R1
Coric, P1
Turcaud, S1
Ishizaki, K1
Sasaki, M1
Karasawa, S1
Obata, H1
Nara, T1
Goto, F1
Huang, SM1
Bisogno, T1
Petros, TJ1
Chang, SY1
Zavitsanos, PA1
Zipkin, RE1
Sivakumar, R1
Coop, A1
Maeda, DY1
De Petrocellis, L1
Burstein, S1
Di Marzo, V1
Walker, JM1
Beyer, C1
Banas, C1
Gomora, P1
Komisaruk, BR1

Reviews

4 reviews available for alanine and Ache

ArticleYear
Current Status of Pain Management in Parkinson's Disease.
    The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 2020, Volume: 47, Issue:3

    Topics: Acetylcholine Release Inhibitors; Alanine; Analgesics; Antiparkinson Agents; Apomorphine; Benzylamin

2020
Comprehensive Examination of Therapies for Pain in Parkinson's Disease: A Systematic Review and Meta-Analysis.
    Neuroepidemiology, 2018, Volume: 51, Issue:3-4

    Topics: Alanine; Analgesics; Benzylamines; Electric Stimulation Therapy; Humans; Pain; Pain Management; Park

2018
[Maybe it hurts more than we think! Neonatal pain].
    Ideggyogyaszati szemle, 2014, Jul-30, Volume: 67, Issue:7-8

    Topics: Alanine; Animals; Blood Pressure; Fetus; Heart Rate; Humans; Infant, Newborn; Infant, Premature; Lac

2014
Alterations in metabolism following injury: part II.
    Injury, 1980, Volume: 11, Issue:4

    Topics: Alanine; Amino Acids; Amino Acids, Branched-Chain; Animals; Carbohydrate Metabolism; Endocrine Gland

1980

Trials

2 trials available for alanine and Ache

ArticleYear
Effects of safinamide adjunct therapy on pain in patients with Parkinson's disease: Post hoc analysis of a Japanese phase 2/3 study.
    Journal of the neurological sciences, 2021, 10-15, Volume: 429

    Topics: Alanine; Antiparkinson Agents; Benzylamines; Humans; Japan; Levodopa; Pain; Parkinson Disease

2021
Effects of Safinamide on Pain in Fluctuating Parkinson's Disease Patients: A Post-Hoc Analysis.
    Journal of Parkinson's disease, 2017, Volume: 7, Issue:1

    Topics: Adult; Aged; Alanine; Benzylamines; Double-Blind Method; Female; Humans; Male; Middle Aged; Outcome

2017

Other Studies

18 other studies available for alanine and Ache

ArticleYear
Effects of safinamide on pain in patients with fluctuating Parkinson's disease.
    Brain and behavior, 2021, Volume: 11, Issue:10

    Topics: Alanine; Antiparkinson Agents; Benzylamines; Humans; Pain; Parkinson Disease; Pilot Projects; Qualit

2021
Efficacy of safinamide as add-on therapy after subthalamic nucleus deep brain stimulation in Parkinson disease.
    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2022, Volume: 43, Issue:5

    Topics: Alanine; Benzylamines; Deep Brain Stimulation; Dyskinesias; Humans; Levodopa; Pain; Parkinson Diseas

2022
Non-motor symptoms burden in motor-fluctuating patients with Parkinson's disease may be alleviated by safinamide: the VALE-SAFI study.
    Journal of neural transmission (Vienna, Austria : 1996), 2022, Volume: 129, Issue:11

    Topics: Alanine; Benzylamines; Fatigue; Female; Humans; Male; Pain; Parkinson Disease; Quality of Life

2022
Effects of safinamide on pain in Parkinson's disease with motor fluctuations: an exploratory study.
    Journal of neural transmission (Vienna, Austria : 1996), 2020, Volume: 127, Issue:8

    Topics: Alanine; Antiparkinson Agents; Benzylamines; Humans; Pain; Parkinson Disease; Quality of Life

2020
Merging the structural motifs of functionalized amino acids and alpha-aminoamides: compounds with significant anticonvulsant activities.
    Journal of medicinal chemistry, 2010, May-13, Volume: 53, Issue:9

    Topics: Acetamides; Alanine; Amides; Amino Acids; Animals; Anticonvulsants; Benzylamines; Drug Evaluation, P

2010
Rebamipide attenuates pain severity and cartilage degeneration in a rat model of osteoarthritis by downregulating oxidative damage and catabolic activity in chondrocytes.
    Osteoarthritis and cartilage, 2012, Volume: 20, Issue:11

    Topics: Alanine; Analgesics; Animals; Arthritis, Experimental; Biomarkers; Cartilage, Articular; Cells, Cult

2012
Pain inhibition by blocking leukocytic and neuronal opioid peptidases in peripheral inflamed tissue.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2012, Volume: 26, Issue:12

    Topics: Alanine; Amino Acid Sequence; Animals; Antibodies; CD13 Antigens; Dose-Response Relationship, Drug;

2012
Augmented chondroprotective effect of coadministration of celecoxib and rebamipide in the monosodium iodoacetate rat model of osteoarthritis.
    Archives of pharmacal research, 2013, Volume: 36, Issue:1

    Topics: Administration, Oral; Alanine; Animals; Arthritis, Experimental; Behavior, Animal; Cartilage; Celeco

2013
Differential changes of group II and group III mGluR function in central amygdala neurons in a model of arthritic pain.
    Journal of neurophysiology, 2006, Volume: 96, Issue:4

    Topics: Alanine; Aminobutyrates; Amygdala; Animals; Arthritis; Bridged Bicyclo Compounds; Disease Models, An

2006
Alteration in sensitivity of ionotropic glutamate receptors and tachykinin receptors in spinal cord contribute to development and maintenance of nerve injury-evoked neuropathic pain.
    Neuroscience research, 2006, Volume: 56, Issue:1

    Topics: Alanine; Analgesics; Animals; Behavior, Animal; Benzamides; Dizocilpine Maleate; Excitatory Amino Ac

2006
Intrathecal injection of glutamate receptor antagonists/agonist selectively attenuated rat pain-related behaviors induced by the venom of scorpion Buthus martensi Karsch.
    Toxicon : official journal of the International Society on Toxinology, 2007, Dec-15, Volume: 50, Issue:8

    Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Alanine; Animals; Dizocilpine Maleate; Excitatory Amino Acid A

2007
Test-specific effects of the 5-HT reuptake inhibitors alaproclate and zimelidine on pain sensitivity and morphine analgesia.
    Journal of neural transmission, 1980, Volume: 47, Issue:4

    Topics: Alanine; Analgesia; Animals; Behavior, Animal; Brompheniramine; Desipramine; Dose-Response Relations

1980
Requirement of metabotropic glutamate receptors for the generation of inflammation-evoked hyperexcitability in rat spinal cord neurons.
    The European journal of neuroscience, 1994, Jul-01, Volume: 6, Issue:7

    Topics: Acute Disease; Afferent Pathways; Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid;

1994
Behavioural and electrophysiological evidence supporting a role for group I metabotropic glutamate receptors in the mediation of nociceptive inputs to the rat spinal cord.
    Brain research, 1997, Nov-28, Volume: 777, Issue:1-2

    Topics: Alanine; Animals; Antihypertensive Agents; Behavior, Animal; Benzothiadiazines; Cycloleucine; Electr

1997
Pain-suppressive effects on various nociceptive stimuli (thermal, chemical, electrical and inflammatory) of the first orally active enkephalin-metabolizing enzyme inhibitor RB 120.
    Pain, 1997, Volume: 73, Issue:3

    Topics: Administration, Oral; Alanine; Animals; Disulfides; Dose-Response Relationship, Drug; Electric Stimu

1997
Intrathecal co-administration of NMDA antagonist and NK-1 antagonist reduces MAC of isoflurane in rats.
    Acta anaesthesiologica Scandinavica, 1999, Volume: 43, Issue:7

    Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Alanine; Anesthetics, Inhalation; Animals; Biphenyl Compounds;

1999
Identification of a new class of molecules, the arachidonyl amino acids, and characterization of one member that inhibits pain.
    The Journal of biological chemistry, 2001, Nov-16, Volume: 276, Issue:46

    Topics: Alanine; Amidohydrolases; Amino Acids; Animals; Arachidonic Acid; Arachidonic Acids; Brain; Calcium;

2001
Prevention of the convulsant and hyperalgesic action of strychnine by intrathecal glycine and related amino acids.
    Pharmacology, biochemistry, and behavior, 1988, Volume: 29, Issue:1

    Topics: Alanine; Amino Acids; Animals; Betaine; Glycine; Injections, Spinal; Pain; Rats; Rats, Inbred Strain

1988