adenosine has been researched along with Ache in 145 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 12 (8.28) | 18.7374 |
1990's | 48 (33.10) | 18.2507 |
2000's | 48 (33.10) | 29.6817 |
2010's | 29 (20.00) | 24.3611 |
2020's | 8 (5.52) | 2.80 |
Authors | Studies |
---|---|
Chen, L; Cheng, L; Hu, Z; Li, J; Shi, Z; Xu, G; Zhang, S; Zheng, L | 1 |
Ding, B; Gao, D; Hu, B; Xiao, L; Zhang, Y; Zhao, Q | 1 |
Hao, JW; Hu, WP; Li, Q; Li, XM; Liu, TT; Qiao, WL; Qiu, CY; Wei, S | 1 |
Jacobson, KA; Pradhan, B; Pramanik, A; Wen, Z | 1 |
Al-Saraireh, YM; Alsalem, M; Cherchi, F; Haddad, M; Madae'en, S | 1 |
Chen, S; Guo, Y; Song, Y; Wang, LK; Zhang, RY; Zhao, JG; Zhao, L; Zhu, BF | 1 |
Adakudugu, EA; Ameyaw, EO; Anokwah, D; Biney, RP; Henneh, IT; Obese, E; Woode, E | 1 |
Cao, JL; Hao, LY; Jin, T; Liu, X; Pan, Z; Shen, W; Sun, ML; Tao, Y; Xie, L; Xue, ZY; Yang, XX; Ye, XC; Zhang, M; Zhang, Q; Zhou, H | 1 |
Bellieni, CV; Petraglia, F; Vannuccini, S | 1 |
Hsieh, CL; Hsu, HC; Lin, YW; Yen, LT | 1 |
Fischer, L; Morais, RN; Sardi, NF; Tobaldini, G | 1 |
Hsieh, CL; Huang, CP; Liao, HY; Lin, YW | 2 |
Ceruti, S; Magni, G | 1 |
Arruda, BR; da Silva, AV; Lopes, SC; Morais, TC; Rao, VS; Rios, JB; Santos, FA; Trevisan, MT | 1 |
Herrero, JF; Ramos-Zepeda, G | 1 |
Herrero, JF; Herrero-Zorita, C; Ramos-Zepeda, GA | 1 |
André, E; Asth, L; Calo', G; de P Soares-Rachetti, V; Gavioli, EC; Guerrini, R; Holanda, AD; Santos, AR | 1 |
Huang, YG; Shen, L; Xu, L; Zhang, YG | 1 |
Adamah-Biassi, EB; Almonte, AG; Blagovechtchenski, E; Bonin, KD; Budygin, EA; Grinevich, VP; Weiner, JL | 1 |
Fedorova, OV; Shabano, PD; Zarubina, IV | 1 |
Jun, IG; Park, JY | 1 |
Benedek, G; Horvath, G; Kekesi, G; Nagy, E; Tuboly, G | 1 |
Herrala, A; Sowa, NA; Taylor-Blake, B; Twomey, MA; Vihko, P; Voikar, V; Zylka, MJ | 1 |
Connor, M | 1 |
Antunes, C; Böhmer, AE; Elisabetsky, E; Lara, DR; Porciúncula, LO; Schallenberger, C; Schmidt, AP; Souza, DO | 1 |
Baghdoyan, HA; Lydic, R; Wang, W | 1 |
Ribeiro, JA; Sebastião, AM | 1 |
Burnstock, G | 1 |
Kelz, MB; Moore, JT | 1 |
Baghdoyan, HA; Lydic, R; Watson, CJ; Watson, SL | 1 |
Sowa, NA; Taylor-Blake, B; Zylka, MJ | 1 |
Borghi, V; Kowalska, M; Nalepa, I; Pavone, F; Przewłocka, B; Roman, A; Vetulani, J | 1 |
Bekar, L; Chen, JF; Chen, M; Fujita, T; Goldman, N; Han, X; Jensen, TK; Liu, W; Nedergaard, M; Pei, Y; Peng, W; Schnermann, J; Takano, T; Tieu, K; Wang, F; Xu, Q | 1 |
Cressey, D | 1 |
Fredholm, BB; Hao, JX; Li, L; Schulte, G; Wiesenfeld-Hallin, Z; Xu, XJ | 1 |
Sereda, MJ | 1 |
Kim, WM; Lee, HG; Park, CH; Yoon, MH | 1 |
Street, SE; Zylka, MJ | 1 |
Boison, D | 2 |
Hahm, KD; Jeong, SM; Kim, YK; Lee, C; Leem, JG; Park, PH; Shin, JW; Song, JG | 1 |
Guillot, TS; Sowa, NA; Street, SE; Taylor-Blake, B; Vihko, P; Walsh, PL; Wightman, RM; Zylka, MJ | 1 |
Gao, ZG; Jacobson, KA | 1 |
Crea, F; Di Franco, A; Di Monaco, A; Lamendola, P; Lanza, GA; Nerla, R; Sestito, A; Tarzia, P; Valeriani, M; Virdis, D; Vollono, C | 1 |
Gmiro, VE; Serdiuk, SE | 1 |
Guan, L; Mu, Y; Quaglia, LA; Shih, MC; Tang, Q; Wang, C; Yang, L | 1 |
Bastia, E; Bertorelli, R; Monopoli, A; Varani, K | 1 |
Curry, R; Eisenach, JC; Hood, DD | 3 |
Borghi, V; Ilona, O; Labuz, D; Maj, M; Pavone, F; Przewlocka, B | 1 |
Arendt-Nielsen, L; Graven-Nielsen, T; Jansson, Y; Kristensen, JD; Mense, S; Segerdahl, M; Sollevi, A | 1 |
Clark, AJ; Lynch, ME; Sawynok, J | 1 |
Liu, XJ; Sawynok, J | 1 |
GOMAHR, H | 1 |
MOULTON, R; SPECTOR, WG; WILLOUGHBY, DA | 1 |
Abo-Salem, OM; Bilkei-Gorzo, A; Filipek, B; Hayallah, AM; Müller, CE; Zimmer, A | 1 |
DeLander, GE; Fredholm, BB; Molander, C; Robertson, B; Schulte, G; Shortland, P | 1 |
Berglund, M; Eriksson, BE; Sadigh-Lindell, B; Sylvén, C | 1 |
Inoue, K; Koizumi, S; Tsuda, M | 1 |
Fujita, T; Kawasaki, Y; Kumamoto, E; Lao, LJ; Yang, K | 1 |
Bantel, C; Childers, SR; Conklin, D; Eisenach, JC; Li, X | 1 |
Fujita, T; Kumamoto, E; Yang, K | 1 |
Allen, G; Aumeerally, N; Sawynok, J | 1 |
Andreotti, N; Carrega, L; Devaux, C; Guieu, R; Jouirou, B; Martin-Eauclaire, MF; Peragut, JC; Pham, T; Regaya, I; Rochat, H; Sabatier, JM; Sauze, N; Vacher, H | 1 |
Bae, HB; Choi, JI; Jeong, CY; Jeong, SW; Park, HC; Yoon, MH | 1 |
Bouman, EA; Dagnelie, PC; Skrabanja, AT | 1 |
Fukuda, K; Fukunaga, A; Hayashida, M | 1 |
An, TH; Bae, HB; Choi, JI; Chung, SS; Chung, ST; Jeong, CY; Jeong, SW; Kim, CM; Kim, SJ; Yoo, KY; Yoon, MH | 1 |
Fukuda, K; Fukunaga, A; Hanaoka, K; Hayashida, M; Ichinohe, T; Kaneko, Y; Mamiya, H; Sakurai, S | 1 |
Sawynok, J | 2 |
Buechler, NL; Eisenach, JC; Kim, SA; Martin, TJ; Porreca, F | 1 |
Irnich, D; Lang, PM | 1 |
Cappellacci, L; de Novellis, V; Franchetti, P; Grifantini, M; Luongo, L; Maione, S; Marabese, I; Palazzo, E; Rossi, F; Stella, L; Vita, D | 1 |
Benedek, G; Horvath, G; Kekesi, G; Tuboly, G | 1 |
Diamond, I; Ferré, S; Goldberg, SR; Hourani, SM; Huang, ZL; Kitchen, I; Urade, Y; Yao, L | 1 |
Azdad, K; d'Exaerde, Ade K; Dumont, H; Gall, D; Guntz, E; Pastijn, E; Schiffmann, SN; Sosnowski, M | 1 |
Post, C | 1 |
Chiariello, L; Crea, F; Crossman, DC; Gaspardone, A; Gioffrè, PA; Iamele, M; Pappagallo, M; Tomai, F; Versaci, F | 1 |
Charest, J; Li, J; Marchand, S | 1 |
Foster, AC; Miller, LP; Wiesner, JB | 1 |
Arai, Y; Kisara, K; Nagaoka, H; Nakagawa, Y; Sakurada, S; Sakurada, T; Takeda, S | 1 |
Chiariello, L; Crea, F; Gaspardone, A; Gioffrè, G; Gioffrè, PA; Iamele, M; Tomai, F; Versaci, F | 1 |
Ekblom, A; Segerdahl, M; Sollevi, A | 1 |
Chen, JY; Dafny, N; Qiao, JT; Xie, YF; Yang, SW; Zhang, ZH | 1 |
Sylvén, C | 1 |
Crea, F; Gaspardone, A; Gioffré, PA; Iamele, M; Pappagallo, M; Tomai, F | 1 |
Ahlgren, SC; Levine, JD | 1 |
Guieu, R | 1 |
Belardinelli, L; Bertolet, BD; Franco, EA; Hill, JA; Kerensky, RA; Nichols, WW | 1 |
Lee, YW; Yaksh, TL | 1 |
Burnstock, G; Wood, JN | 1 |
DeLander, GE; Keil, GJ | 1 |
Acciavatti, A; Capecchi, PL; Cati, G; Ceccatelli, L; Colafati, M; de Lalla, A; Di Perri, T; Pasini, FL; Petri, S | 1 |
Sollevi, A | 1 |
Snyder, SH | 1 |
Costentin, J; El Yacoubi, M; Heath, JK; Ledent, C; Parmentier, M; Pedrazzini, T; Schiffmann, SN; Vanderhaeghen, JJ; Vassart, G; Vaugeois, JM | 1 |
Guieu, R; Guy, B; Pouget, J; Rochat, H; Sampiéri, F | 1 |
Kemmotsu, O; Nakamura, I; Ohta, Y | 1 |
Dickenson, AH; Kerr, NC; Reeve, AJ | 1 |
Akimoto, T; Mashimoto, S; Suetsugi, M; Ushijima, I; Watanabe, K; Yamada, M | 1 |
Hao, JX; Sjölund, KF; Sollevi, A; von Heijne, M; Wiesenfeld-Hallin, Z; Xu, XJ | 1 |
Cui, JG; Linderoth, B; Meyerson, BA; O'Connor, WT; Segerdahl, M; Sollevi, A; Stiller, CO; Yakhnitsa, V | 1 |
Khandwala, H; Loomis, CW; Zhang, Z | 1 |
Hao, JX; Sollevi, A; von Heijne, M; Wiesenfeld-Hallin, Z; Xu, XJ; Yu, W | 1 |
Arnér, S | 1 |
Bhagwat, SS; Jarvis, MF; Kowaluk, EA | 1 |
Eisenach, JC; Lavand'homme, PM | 1 |
Esser, MJ; Reid, AR; Sawynok, J | 1 |
Arnér, S; Belfrage, M; Segerdahl, M; Sollevi, A | 1 |
Dryden, C; Kinsella, J; Mansfield, MD; Rae, CP | 1 |
Dafny, N; Kang, YM; Qiao, JT; Zhang, C; Zhao, Y | 1 |
Eisenach, JC; Gomes, JA; Li, X; Pan, HL | 1 |
Hao, JX; Sollevi, A; von Heijne, M; Xu, XJ | 1 |
Gebhart, GF; Su, X; Wachtel, RE | 1 |
Aley, KO; Levine, JD; Messing, RO; Mochly-Rosen, D | 1 |
Hazato, T; Inoue, M; Matsunaga, S; Ueda, H; Yamamoto, Y | 1 |
Cook, SP; McCleskey, EW; Sutherland, SP | 1 |
Eisenach, JC; Leung, E; Pan, HL; Xu, Z | 1 |
Gyllenhammar, E; Nordfors, LO | 1 |
Rosen, SD | 1 |
Bantel, C; Chen, SR; Childers, SR; Eisenach, JC; Li, X; Tobin, JR | 1 |
Han, BF; Qi, JS; Qiao, JT; Zhang, C | 1 |
Bourgoin, S; Cesselin, F; Hamon, M; Mauborgne, A; Poliénor, H | 1 |
Canković-Darracott, S; Chayen, J; Jenkins, BS; Malcolm, AD; Webb-Peploe, MM | 1 |
Bleehen, T; Keele, CA | 1 |
Heller, PH; Levine, JD; Taiwo, YO | 1 |
Hayaishi, O; Horiguchi, S; Hyodo, M; Ito, S; Minami, T; Uda, R | 1 |
De Koninck, Y; Henry, JL | 1 |
Arndt, JO; Klement, W | 1 |
Beermann, B; Jonzon, B; Kaijser, L; Sylvén, C | 1 |
Belvedere, DA; Coyne, EP; Evans, RB; Spaccavento, LJ; Vande Streek, PR; Weiland, FL | 1 |
Isbrucker, R; Reid, A; Sawynok, J | 1 |
Aran, S; Proudfit, HK | 2 |
Boyce, TM; Hixson, JB; Mahmarian, JJ; Staudacher, RA; Verani, MS | 1 |
DeLander, GE; Wahl, JJ | 1 |
Sawynok, J; Sweeney, MI | 1 |
Sosnowski, M; Stevens, CW; Yaksh, TL | 1 |
Sawynok, J; Sweeney, MI; White, TD | 1 |
Horne, JJ; Lewis, DJ; Smith, PM; Watt, AH | 1 |
Fredholm, BB; Jonzon, B; Kaijser, L; Sylvén, C | 1 |
Juan, H; Lembeck, F | 1 |
23 review(s) available for adenosine and Ache
Article | Year |
---|---|
New paradigms in purinergic receptor ligand discovery.
Topics: Adenosine; Humans; Inflammation; Ligands; Pain; Purinergic P1 Receptor Antagonists; Receptors, Purinergic | 2023 |
Adenosine Receptors as Potential Therapeutic Analgesic Targets.
Topics: Adenosine; Analgesics; Humans; Ligands; Pain; Receptors, Purinergic P1 | 2023 |
Is fetal analgesia necessary during prenatal surgery?
Topics: Adenosine; Analgesia; Anesthesia; Arousal; Female; Fetal Blood; Fetus; Gestational Age; Humans; MEDLINE; Nervous System; Pain; Pain Management; Pregnancy; Pregnanolone; Prostaglandin D2 | 2018 |
The role of adenosine and P2Y receptors expressed by multiple cell types in pain transmission.
Topics: Adenosine; Adenosine Triphosphate; Analgesics; Animals; Central Nervous System; Humans; Neuroglia; Neurons; Pain; Receptors, Purinergic; Receptors, Purinergic P2Y; Signal Transduction | 2019 |
Regulatory effect of caffeine on the acute and the chronic pain and its possible mechanisms.
Topics: Adenosine; Caffeine; Central Nervous System Stimulants; Chronic Pain; Humans; Pain | 2014 |
Adenosine receptors and the central nervous system.
Topics: Adenosine; Aging; Animals; Brain; Brain-Derived Neurotrophic Factor; Humans; Neurotransmitter Agents; Pain; Receptors, Cannabinoid; Receptors, Metabotropic Glutamate; Receptors, Purinergic P1; Sleep; Synaptic Transmission | 2009 |
Purines and sensory nerves.
Topics: Adenosine; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Central Nervous System; Ganglia, Sensory; Humans; Mechanotransduction, Cellular; Neural Pathways; Pain; Purines; Receptors, Purinergic; Receptors, Purinergic P1; Receptors, Purinergic P2; Sensation Disorders; Sensory Receptor Cells; Viscera | 2009 |
Modulators of nucleoside metabolism in the therapy of brain diseases.
Topics: Adenosine; Adenosine Kinase; Analgesics; Animals; Anticonvulsants; Brain; Brain Diseases; Epilepsy; Gene Expression; Humans; Metabolic Networks and Pathways; Mice; Mice, Knockout; Neuroprotective Agents; Pain; Protein Kinase Inhibitors; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Receptor, Adenosine A1; Receptor, Adenosine A2A; Schizophrenia; Signal Transduction; Sleep Wake Disorders | 2011 |
Adenosine in the spinal cord and periphery: release and regulation of pain.
Topics: Adenosine; Afferent Pathways; Animals; Humans; Pain; Peripheral Nerves; Spinal Cord | 2003 |
ATP- and adenosine-mediated signaling in the central nervous system: chronic pain and microglia: involvement of the ATP receptor P2X4.
Topics: Adenosine; Adenosine Triphosphate; Animals; Central Nervous System; Chronic Disease; Humans; Microglia; Pain; Receptors, Purinergic P2; Receptors, Purinergic P2X4; Signal Transduction | 2004 |
Potential value of adenosine 5'-triphosphate (ATP) and adenosine in anaesthesia and intensive care medicine.
Topics: Adenosine; Adenosine Triphosphate; Anesthesia; Critical Care; Hemodynamics; Humans; Pain; Shock, Septic | 2005 |
Clinical application of adenosine and ATP for pain control.
Topics: Acute Disease; Adenosine; Adenosine Triphosphate; Animals; Chronic Disease; Humans; Injections, Intravenous; Injections, Spinal; Pain; Pain, Postoperative | 2005 |
Adenosine and ATP receptors.
Topics: Adenosine; Analgesics; Animals; Humans; Pain; Receptors, Purinergic P1; Receptors, Purinergic P2 | 2007 |
Adenosine A2A receptors in ventral striatum, hypothalamus and nociceptive circuitry implications for drug addiction, sleep and pain.
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Animals; Basal Ganglia; Humans; Hypothalamus; Neural Pathways; Pain; Receptor, Adenosine A1; Receptor, Adenosine A2A; Sleep Wake Disorders; Substance-Related Disorders | 2007 |
Adenosine as a neuromodulator in neurological diseases.
Topics: Adenosine; Adenosine Kinase; Alzheimer Disease; Animals; Brain Diseases; Brain Ischemia; Epilepsy; Humans; Huntington Disease; Pain; Parkinson Disease; Schizophrenia; Synaptic Transmission | 2008 |
Regulation of endogenous adenosine levels in the CNS: potential for therapy in stroke, epilepsy and pain.
Topics: Adenosine; Animals; Central Nervous System; Central Nervous System Diseases; Cerebrovascular Disorders; Epilepsy; Homeostasis; Humans; Pain; Receptors, Purinergic P1 | 1994 |
Mechanisms of pain in angina pectoris--a critical review of the adenosine hypothesis.
Topics: Adenosine; Angina Pectoris; Humans; Pain | 1993 |
Purinergic receptors: their role in nociception and primary afferent neurotransmission.
Topics: Adenosine; Adenosine Triphosphate; Afferent Pathways; Animals; Humans; Neurons, Afferent; Nociceptors; Pain; Receptors, Purinergic; Synaptic Transmission | 1996 |
Adenosine for pain control.
Topics: Acute Disease; Adenosine; Analgesics; Analgesics, Opioid; Animals; Central Nervous System; Chronic Disease; Disease Models, Animal; Hot Temperature; Humans; Infusions, Intravenous; Injections, Intravenous; Injections, Spinal; Neurons, Afferent; Nociceptors; Pain; Peripheral Nerves; Pressure; Receptors, Cell Surface; Rodentia; Spinal Cord; Touch | 1997 |
Adenosine receptor activation and nociception.
Topics: Adenosine; Adenosine Triphosphate; Analgesics; Animals; Humans; Nociceptors; Pain; Receptors, Purinergic P1 | 1998 |
Adenosine kinase inhibitors.
Topics: Adenosine; Adenosine Kinase; Animals; Chemistry, Pharmaceutical; Enzyme Inhibitors; Humans; In Vitro Techniques; Inflammation; Pain; Wounds and Injuries | 1998 |
Chemical mediators of pain due to tissue damage and ischemia.
Topics: Acetylcholine; Acid Sensing Ion Channels; Adenosine; Adenosine Triphosphate; Afferent Pathways; Animals; Bradykinin; Glutamic Acid; Heart; Humans; Lactic Acid; Membrane Proteins; Myocardial Ischemia; Nerve Tissue Proteins; Neurons, Afferent; Nociceptors; Pain; Potassium; Proton Pumps; Receptors, Purinergic P2; Signal Transduction; Sodium Channels | 2000 |
The role of purines in nociception.
Topics: Adenosine; Adenosine Triphosphate; Animals; Central Nervous System; Pain; Second Messenger Systems | 1989 |
14 trial(s) available for adenosine and Ache
Article | Year |
---|---|
Dose response of intrathecal adenosine in experimental pain and allodynia.
Topics: Adenosine; Administration, Topical; Adult; Aminophylline; Analgesics, Non-Narcotic; Blood Pressure; Capsaicin; Dose-Response Relationship, Drug; Double-Blind Method; Female; Heart Rate; Hot Temperature; Humans; Hyperalgesia; Hypersensitivity; Infusions, Intravenous; Injections, Spinal; Male; Middle Aged; Pain; Pain Measurement; Phosphodiesterase Inhibitors; Purinergic P1 Receptor Antagonists | 2002 |
Intravenous adenosine alleviates neuropathic pain: a double blind placebo controlled crossover trial using an enriched enrolment design.
Topics: Adenosine; Adult; Analgesics; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Cross-Over Studies; Double-Blind Method; Humans; Hyperalgesia; Infusions, Intravenous; Middle Aged; Neuralgia; Pain; Pain Measurement; Pain Threshold; Placebos; Sensation; Sensory Thresholds; Time; Time Factors; Treatment Outcome | 2003 |
Role of adenosine and opioid-receptor mechanisms for pain in patients with silent myocardial ischemia or angina pectoris: a double-blind, placebo-controlled study.
Topics: Adenosine; Angina Pectoris; Blood Pressure; Double-Blind Method; Heart Rate; Humans; Male; Middle Aged; Myocardial Infarction; Naloxone; Narcotic Antagonists; Pain; Pain Measurement; Pain Threshold; Time Factors | 2003 |
Substance P potentiates the algogenic effects of intraarterial infusion of adenosine.
Topics: Adenosine; Adult; Aged; Chest Pain; Coronary Vessels; Drug Synergism; Female; Humans; Iliac Artery; Infusions, Intra-Arterial; Male; Middle Aged; Pain; Pain Threshold; Substance P | 1994 |
Effects of caffeine on analgesia from transcutaneous electrical nerve stimulation.
Topics: Adenosine; Adult; Caffeine; Double-Blind Method; Female; Humans; Male; Pain; Pain Measurement; Transcutaneous Electric Nerve Stimulation | 1995 |
Muscular and cardiac adenosine-induced pain is mediated by A1 receptors.
Topics: Adenosine; Adult; Aged; Analgesics; Angina Pectoris; Dose-Response Relationship, Drug; Female; Humans; Iliac Artery; Infusions, Intra-Arterial; Male; Middle Aged; Muscular Diseases; Pain; Pain Measurement; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Theophylline | 1995 |
The influence of adenosine, ketamine, and morphine on experimentally induced ischemic pain in healthy volunteers.
Topics: Adenosine; Adult; Drug Interactions; Drug Therapy, Combination; Female; Humans; Ischemia; Ketamine; Male; Morphine; Muscles; Pain; Single-Blind Method | 1994 |
Analgesic effect of bamiphylline on pain induced by intradermal injection of adenosine.
Topics: Adenosine; Adult; Analgesics; Female; Humans; Injections, Intradermal; Male; Pain; Receptors, Purinergic; Sodium Chloride; Theophylline | 1993 |
The safety and efficacy of intrathecal adenosine in patients with chronic neuropathic pain.
Topics: Adenosine; Adult; Chronic Disease; Female; Humans; Injections, Spinal; Male; Middle Aged; Pain | 1999 |
Analgesic effect of adenosine on ischaemic pain in human volunteers.
Topics: Adenosine; Analgesics; Arm; Cross-Over Studies; Double-Blind Method; Humans; Ischemia; Male; Pain; Tourniquets | 1999 |
Phase I safety assessment of intrathecal injection of an American formulation of adenosine in humans.
Topics: Adenosine; Adult; Analgesics; Back Pain; Double-Blind Method; Female; Humans; Injections, Spinal; Leg; Male; Pain | 2002 |
Preliminary efficacy assessment of intrathecal injection of an American formulation of adenosine in humans.
Topics: Adenosine; Adult; Analgesics; Capsaicin; Double-Blind Method; Female; Humans; Hyperalgesia; Injections, Spinal; Male; Middle Aged; Pain; Pain Threshold | 2002 |
Reproduction of epigastric pain of duodenal ulceration by adenosine.
Topics: Adenosine; Adult; Aminophylline; Duodenal Ulcer; Humans; Male; Middle Aged; Pain; Pain Measurement | 1987 |
Adenosine injection into the brachial artery produces ischaemia like pain or discomfort in the forearm.
Topics: Adenosine; Adult; Brachial Artery; Forearm; Humans; Injections, Intra-Arterial; Ischemia; Male; Nitroglycerin; Pain; Regional Blood Flow; Vasodilation | 1988 |
108 other study(ies) available for adenosine and Ache
Article | Year |
---|---|
In silico identification of A1 agonists and A2a inhibitors in pain based on molecular docking strategies and dynamics simulations.
Topics: Adenosine; Humans; Molecular Docking Simulation; Pain; Receptor, Adenosine A1; Receptor, Adenosine A2A | 2023 |
N6-Methyladenosine-induced miR-143-3p promotes intervertebral disc degeneration by regulating SOX5.
Topics: Adenosine; Apoptosis; Humans; Intervertebral Disc; Intervertebral Disc Degeneration; Methyltransferases; MicroRNAs; Pain; SOXD Transcription Factors; Tumor Necrosis Factor-alpha | 2022 |
A1 Adenosine Receptor Activation Inhibits P2X3 Receptor-Mediated ATP Currents in Rat Dorsal Root Ganglion Neurons.
Topics: Adenosine; Adenosine Triphosphate; Adenylyl Cyclases; Analgesics; Animals; Colforsin; Ganglia, Spinal; Neurons; Pain; Pertussis Toxin; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Receptors, Purinergic P1; Receptors, Purinergic P2X3 | 2022 |
Electroacupuncture alleviates inflammatory pain via adenosine suppression and its mediated substance P expression.
Topics: Adenosine; Animals; Electroacupuncture; Pain; Rats; Rats, Sprague-Dawley; Substance P | 2020 |
Antinociceptive effect of the hydroethanolic leaf extract of Calotropis procera (Ait) R. Br. (Apocynaceae): Possible involvement of glutamatergic, cytokines, opioidergic and adenosinergic pathways.
Topics: Adenosine; Analgesics; Analgesics, Opioid; Animals; Calotropis; Dose-Response Relationship, Drug; Ghana; Glutamic Acid; Male; Mice; Mice, Inbred ICR; Pain; Pain Measurement; Pain Threshold; Plant Extracts; Plant Leaves | 2021 |
Methyltransferase-like 3 contributes to inflammatory pain by targeting TET1 in YTHDF2-dependent manner.
Topics: Adenosine; Animals; Methyltransferases; Pain; RNA; RNA, Messenger | 2021 |
Targeting ASIC3 for Relieving Mice Fibromyalgia Pain: Roles of Electroacupuncture, Opioid, and Adenosine.
Topics: Acid Sensing Ion Channels; Adenosine; Analgesics, Opioid; Animals; Electroacupuncture; Fibromyalgia; Ganglia, Spinal; Hyperalgesia; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Pain; Pain Management; Signal Transduction | 2017 |
Nucleus accumbens mediates the pronociceptive effect of sleep deprivation: the role of adenosine A2A and dopamine D2 receptors.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Animals; Male; Motor Activity; Nociception; Nucleus Accumbens; Pain; Phenethylamines; Piribedil; Purinergic P1 Receptor Antagonists; Pyrimidines; Rats; Rats, Wistar; Receptor, Adenosine A2A; Receptors, Dopamine D2; Sleep Deprivation; Sleep, REM; Triazoles | 2018 |
Electroacupuncture Attenuates Induction of Inflammatory Pain by Regulating Opioid and Adenosine Pathways in Mice.
Topics: Adenosine; Analgesics, Opioid; Animals; Astrocytes; Cyclooxygenase 2; Disease Models, Animal; Electroacupuncture; Ganglia, Spinal; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Hyperalgesia; Inflammation; Mice; NF-kappa B; Pain; Pain Management; Protein Kinase C-epsilon; Rats; Receptor for Advanced Glycation End Products; S100 Calcium Binding Protein beta Subunit; Signal Transduction; Spinal Cord Dorsal Horn | 2017 |
Peripheral antinociceptive action of mangiferin in mouse models of experimental pain: role of endogenous opioids, K(ATP)-channels and adenosine.
Topics: Adenosine; Adenosine Triphosphate; Analgesics; Animals; Disease Models, Animal; Mice; Opioid Peptides; Pain; Potassium Channels; Xanthones | 2013 |
Interaction of the adenosine A1 receptor agonist N6-cyclopentyladenosine (CPA) and opioid receptors in spinal cord nociceptive reflexes.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Animals; Inflammation; Male; Pain; Pain Measurement; Rats; Rats, Wistar; Receptor, Adenosine A1; Receptors, Opioid; Reflex; Spinal Cord | 2013 |
Interaction of the adenosine A1 receptor agonist N6-cyclopentyladenosine and κ-opioid receptors in rat spinal cord nociceptive reflexes.
Topics: Adenosine; Animals; Carrageenan; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Fentanyl; Inflammation; Male; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Rats; Rats, Wistar; Receptors, Opioid, kappa; Reflex; Spinal Cord | 2014 |
Central adenosine A1 and A2A receptors mediate the antinociceptive effects of neuropeptide S in the mouse formalin test.
Topics: Adenosine; Animals; Formaldehyde; Male; Mice; Neuropeptides; Nociception; Pain; Pain Measurement; Receptor, Adenosine A1; Receptor, Adenosine A2A | 2015 |
Real time adenosine fluctuations detected with fast-scan cyclic voltammetry in the rat striatum and motor cortex.
Topics: Adenosine; Animals; Carbon; Carbon Fiber; Corpus Striatum; Electrochemical Techniques; Electrodes, Implanted; Male; Motor Cortex; Pain; Physical Stimulation; Rats, Long-Evans; Tail; Time | 2015 |
[ANALGESIC EFFECT OF TROPALGIN ON THERMAL PAIN IN RATS WITH DIFFERENT PAIN THRESHOLDS].
Topics: Adenosine; Analgesics; Animals; Burns; Dipyrone; Male; Pain; Rats; Rats, Wistar | 2015 |
Electroacupuncture Attenuates CFA-induced Inflammatory Pain by suppressing Nav1.8 through S100B, TRPV1, Opioid, and Adenosine Pathways in Mice.
Topics: Acupuncture Analgesia; Adenosine; Analgesics, Opioid; Animals; Behavior, Animal; Biomarkers; Chromones; Disease Models, Animal; Electroacupuncture; Freund's Adjuvant; Gene Deletion; Gene Expression; Gene Knockout Techniques; Glial Fibrillary Acidic Protein; Male; Mice; Morpholines; NAV1.8 Voltage-Gated Sodium Channel; Neurons; Pain; Pain Management; Proto-Oncogene Proteins c-akt; S100 Calcium Binding Protein beta Subunit; Signal Transduction; Spinal Cord Dorsal Horn; TOR Serine-Threonine Kinases; TRPV Cation Channels; Xanthines | 2017 |
The interaction of gabapentin and N6-(2-phenylisopropyl)-adenosine R-(-)isomer (R-PIA) on mechanical allodynia in rats with a spinal nerve ligation.
Topics: Adenosine; Amines; Animals; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Gabapentin; gamma-Aminobutyric Acid; Injections, Spinal; Ligation; Male; Pain; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Spinal Nerves; Xanthines | 2008 |
The antinociceptive interaction of anandamide and adenosine at the spinal level.
Topics: Adenosine; Analgesics; Animals; Arachidonic Acids; Caffeine; Dose-Response Relationship, Drug; Drug Interactions; Endocannabinoids; Hot Temperature; Inflammation; Injections, Spinal; Male; Pain; Pain Measurement; Polyunsaturated Alkamides; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Reaction Time | 2009 |
Prostatic acid phosphatase is an ectonucleotidase and suppresses pain by generating adenosine.
Topics: 5'-Nucleotidase; Acid Phosphatase; Adenosine; Animals; Ganglia, Spinal; Humans; Isoenzymes; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Pain; Pain Measurement; Protein Tyrosine Phosphatases; Receptor, Adenosine A1 | 2008 |
Allopurinol for pain relief: more than just crystal clearance?
Topics: Adenosine; Adenosine A1 Receptor Agonists; Allopurinol; Analgesics; Animals; Gout; Mice; Pain; Reactive Oxygen Species; Xanthine Oxidase | 2009 |
Anti-nociceptive properties of the xanthine oxidase inhibitor allopurinol in mice: role of A1 adenosine receptors.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Allopurinol; Analgesics; Animals; Capsaicin; Dose-Response Relationship, Drug; Glutamic Acid; Hot Temperature; Injections, Intraperitoneal; Male; Mice; Naloxone; Narcotic Antagonists; Pain; Pain Measurement; Pyrimidines; Triazoles; Uric Acid; Xanthine Oxidase; Xanthines | 2009 |
Leptin replacement restores supraspinal cholinergic antinociception in leptin-deficient obese mice.
Topics: Acetylcholine; Adenosine; Animals; Carbachol; Cholinergic Agonists; Cholinesterase Inhibitors; Hot Temperature; Leptin; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Morphine; Neostigmine; Nicotine; Obesity; Pain; Pain Measurement; Pons; Time Factors | 2009 |
Opiates, sleep, and pain: the adenosinergic link.
Topics: Adenosine; Analgesics, Opioid; Animals; Arousal; Brain Chemistry; Humans; Pain; Sleep | 2009 |
Thermal nociception is decreased by hypocretin-1 and an adenosine A1 receptor agonist microinjected into the pontine reticular formation of Sprague Dawley rat.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Aging; Animals; Benzoxazoles; Hot Temperature; Intracellular Signaling Peptides and Proteins; Male; Microinjections; Naphthyridines; Neuropeptides; Orexin Receptors; Orexins; Pain; Pain Measurement; Pons; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Reticular Formation; Time Factors; Urea | 2010 |
Ecto-5'-nucleotidase (CD73) inhibits nociception by hydrolyzing AMP to adenosine in nociceptive circuits.
Topics: 5'-Nucleotidase; Adenosine; Adenosine Monophosphate; Animals; Cell Membrane; Ganglia, Spinal; Hydrolysis; Hyperalgesia; Inflammation; Male; Mice; Mice, Knockout; Nerve Endings; Nociceptors; Pain; Presynaptic Terminals; Receptor, Adenosine A1; Sciatic Nerve; Skin | 2010 |
Changes induced by formalin pain in central alpha1-adrenoceptor density are modulated by adenosine receptor agonists.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Analgesics; Animals; Autoradiography; Central Nervous System; Disease Models, Animal; Inflammation; Male; Mice; Nociceptors; Pain; Pain Measurement; Phenethylamines; Prazosin; Receptor, Adenosine A2A; Receptors, Adrenergic, alpha-1 | 2010 |
Adenosine A1 receptors mediate local anti-nociceptive effects of acupuncture.
Topics: Acupuncture Analgesia; Adenosine; Afferent Pathways; Analysis of Variance; Animals; Disease Models, Animal; Mice; Nucleotidases; Pain; Pain Management; Peripheral Nervous System Diseases; Receptors, Purinergic P1; Sciatica; Statistics, Nonparametric | 2010 |
Acupuncture for mice.
Topics: Acupuncture Therapy; Adenosine; Animals; Caffeine; Humans; Mice; Models, Animal; Pain; Pain Management; Pentostatin; Placebo Effect; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1 | 2010 |
Peripheral adenosine A2A receptors are involved in carrageenan-induced mechanical hyperalgesia in mice.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Carrageenan; Female; Ganglia, Spinal; Hyperalgesia; Inflammation; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Mice; Mice, Knockout; Pain; Pain Threshold; Phenethylamines; Receptor, Adenosine A2A; Sex Characteristics; Triazines; Triazoles | 2010 |
Purines 2010: Adenine Nucleosides and Nucleotides in Biomedicine.
Topics: Adenine Nucleotides; Adenosine; Anemia, Sickle Cell; Bone and Bones; Cystic Fibrosis; Drug Design; Drugs, Investigational; Humans; Neoplasms; Neurodegenerative Diseases; Pain; Pulmonary Fibrosis; Receptors, Purinergic; Signal Transduction | 2010 |
Roles of adenosine and serotonin receptors on the antinociception of sildenafil in the spinal cord of rats.
Topics: Adenosine; Analgesics; Animals; Cyclic GMP; Dihydroergocristine; Injections, Spinal; Male; Pain; Piperazines; Purines; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Receptors, Serotonin; Sildenafil Citrate; Spinal Cord; Sulfones; Vasodilator Agents | 2010 |
Emerging roles for ectonucleotidases in pain-sensing neurons.
Topics: 5'-Nucleotidase; Acid Phosphatase; Adenosine; Adenosine A1 Receptor Agonists; Animals; Ganglia, Spinal; GPI-Linked Proteins; Humans; Nociceptors; Nucleotidases; Pain; Protein Tyrosine Phosphatases; Receptor, Adenosine A1 | 2011 |
Adenosine triphosphate-sensitive potassium channel blockers attenuate the antiallodynic effect of R-PIA in neuropathic rats.
Topics: 4-Aminopyridine; Adenosine; Adenosine Triphosphate; Animals; Glyburide; Humans; Hyperalgesia; Injections, Spinal; Male; Neurons; Pain; Potassium Channel Blockers; Rats; Rats, Sprague-Dawley; Spinal Nerves | 2011 |
PAP and NT5E inhibit nociceptive neurotransmission by rapidly hydrolyzing nucleotides to adenosine.
Topics: 5'-Nucleotidase; Acid Phosphatase; Adenosine; Adenosine Monophosphate; Animals; Dipyridamole; Ganglia, Spinal; Male; Mice; Mice, Knockout; Nociception; Nucleotides; Pain; Protein Tyrosine Phosphatases; Receptor, Adenosine A1; Synaptic Transmission; Tubercidin | 2011 |
Emerging adenosine receptor agonists: an update.
Topics: Adenosine; Arrhythmias, Cardiac; Clinical Trials as Topic; Diabetes Mellitus; Drugs, Investigational; Humans; Inflammation; Molecular Structure; Pain; Purinergic P1 Receptor Agonists; Treatment Outcome | 2011 |
Coronary microvascular function and cortical pain processing in patients with silent positive exercise testing and normal coronary arteries.
Topics: Adenosine; Aged; Blood Flow Velocity; Case-Control Studies; Cold Temperature; Coronary Angiography; Coronary Circulation; Coronary Vessels; Echocardiography; Echocardiography, Doppler; Evoked Potentials, Somatosensory; Exercise Test; False Positive Reactions; Female; Humans; Male; Microcirculation; Microvascular Angina; Middle Aged; Pain; Vasodilator Agents | 2012 |
[Peripheral acting mediators pain and analgesia potentiate the central analgesic action of fentanyl and dipyrone].
Topics: Adenosine; Adenosine Triphosphate; Analgesia; Analgesics; Animals; Dipyrone; Dose-Response Relationship, Drug; Drug Synergism; Fentanyl; Glutamic Acid; Male; Pain; Phenylephrine; Rats; Rats, Wistar | 2012 |
Effectiveness of myocardial contrast echocardiography quantitative analysis during adenosine stress versus visual analysis before percutaneous therapy in acute coronary pain: a coronary artery TIMI grading comparing study.
Topics: Acute Coronary Syndrome; Adenosine; Adult; Aged; Analysis of Variance; Coronary Angiography; Echocardiography; Female; Hemodynamics; Humans; Male; Middle Aged; Myocardial Infarction; Pain; Reproducibility of Results; Sensitivity and Specificity; Severity of Illness Index | 2012 |
Effects of A(1) and A(2A) adenosine receptor ligands in mouse acute models of pain.
Topics: Acute Disease; Adenosine; Animals; Behavior, Animal; Ligands; Mice; Nociceptors; Pain; Pain Measurement; Pyrimidines; Receptor, Adenosine A2A; Receptors, Purinergic P1; Triazoles | 2002 |
Formalin-induced pain and mu-opioid receptor density in brain and spinal cord are modulated by A1 and A2a adenosine agonists in mice.
Topics: Adenosine; Animals; Autoradiography; Central Nervous System; Fixatives; Formaldehyde; Male; Mice; Motor Activity; Naltrexone; Narcotic Antagonists; Pain; Periaqueductal Gray; Phenethylamines; Purinergic P1 Receptor Agonists; Receptor, Adenosine A2A; Receptors, Opioid, mu; Receptors, Purinergic P1; Spinal Cord; Thalamus | 2002 |
Experimental pain by ischaemic contractions compared with pain by intramuscular infusions of adenosine and hypertonic saline.
Topics: Adenosine; Adult; Exercise; Female; Humans; Injections, Intramuscular; Ischemia; Male; Muscle Contraction; Muscle, Skeletal; Nociceptors; Pain; Pain Measurement; Pain Threshold; Pressure; Saline Solution, Hypertonic; Vasodilator Agents | 2003 |
[Influence of adenosine on the action of dimethylaminophenyldimethylpyrazolon].
Topics: Adenosine; Aminopyrine; Analgesia; Anesthesia; Anesthesia and Analgesia; Pain | 1956 |
Histamine release and pain production by xanthosine and related compounds.
Topics: Adenosine; Animals; Cats; Female; Guanosine; Guinea Pigs; Histamine; Histamine Release; Humans; Ileum; Injections, Intradermal; Inosine; Male; Nucleosides; Nucleotides; Pain; Ribonucleosides; Xanthine; Xanthines | 1957 |
Antinociceptive effects of novel A2B adenosine receptor antagonists.
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Analgesia; Animals; Caffeine; Drug Synergism; Male; Mice; Morphine; Pain | 2004 |
Distribution of antinociceptive adenosine A1 receptors in the spinal cord dorsal horn, and relationship to primary afferents and neuronal subpopulations.
Topics: Adenosine; Afferent Pathways; Biomarkers; Glycoproteins; Lectins; Ligation; Nerve Fibers, Unmyelinated; Nerve Tissue Proteins; Nociceptors; Pain; Posterior Horn Cells; Receptor, Adenosine A1; Receptors, AMPA; Rhizotomy; Spinal Nerve Roots; Synaptic Transmission | 2003 |
Modulation by adenosine of Adelta and C primary-afferent glutamatergic transmission in adult rat substantia gelatinosa neurons.
Topics: Adenosine; Animals; Dose-Response Relationship, Drug; Excitatory Postsynaptic Potentials; Glutamine; Male; Neurons, Afferent; Organ Culture Techniques; Pain; Patch-Clamp Techniques; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Substantia Gelatinosa; Synaptic Transmission | 2004 |
Repeated dosing with oral allosteric modulator of adenosine A1 receptor produces tolerance in rats with neuropathic pain.
Topics: Adenosine; Administration, Oral; Allosteric Regulation; Animals; Drug Tolerance; Male; Pain; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Spinal Nerves; Thiophenes; Xanthines | 2004 |
Adenosine inhibits GABAergic and glycinergic transmission in adult rat substantia gelatinosa neurons.
Topics: 4-Aminopyridine; 8-Bromo Cyclic Adenosine Monophosphate; Adenosine; Animals; Colforsin; GABA Antagonists; gamma-Aminobutyric Acid; Glycine; Neurons; Pain; Phorbol 12,13-Dibutyrate; Potassium Channel Blockers; Potassium Channels; Rats; Substantia Gelatinosa; Synaptic Transmission | 2004 |
Glutamate-evoked release of adenosine and regulation of peripheral nociception.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Citrates; Conditioning, Psychological; Drug Synergism; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Formaldehyde; Gliosis; Glutamic Acid; Male; Microglia; Neural Inhibition; Nociceptors; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Spinal Cord; Theophylline | 2004 |
Small conductance calcium-activated K+ channels, SkCa, but not voltage-gated K+ (Kv) channels, are implicated in the antinociception induced by CGS21680, a A2A adenosine receptor agonist.
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Analgesics; Animals; Apamin; Dose-Response Relationship, Drug; Drug Antagonism; Drug Therapy, Combination; Injections, Intraventricular; Male; Mice; Mice, Inbred C57BL; Pain; Pain Measurement; Pain Threshold; Phenethylamines; Potassium Channels, Calcium-Activated; Potassium Channels, Voltage-Gated; Scorpion Venoms | 2004 |
Analysis of interactions between serotonin and gabapentin or adenosine in the spinal cord of rats.
Topics: Adenosine; Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Drug Synergism; Gabapentin; gamma-Aminobutyric Acid; Injections, Spinal; Male; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Serotonin; Spinal Cord | 2005 |
Evaluation of interaction between intrathecal adenosine and MK801 or NBQX in a rat formalin pain model.
Topics: Adenosine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Disease Models, Animal; Dizocilpine Maleate; Drug Synergism; Excitatory Amino Acid Antagonists; Formaldehyde; Injections, Spinal; Male; N-Methylaspartate; Pain; Quinoxalines; Rats; Rats, Sprague-Dawley | 2005 |
The characteristics of intravenous adenosine-induced antinociception in a rabbit model of acute nociceptive pain: a comparative study with remifentanil.
Topics: Adenosine; Analgesics; Analgesics, Opioid; Anesthetics, Inhalation; Animals; Blood Pressure; Carbon Dioxide; Disease Models, Animal; Heart Rate; Infusions, Intravenous; Isoflurane; Male; Nociceptors; Pain; Pain Measurement; Piperidines; Rabbits; Remifentanil; Respiration | 2006 |
Opioid self-administration in the nerve-injured rat: relevance of antiallodynic effects to drug consumption and effects of intrathecal analgesics.
Topics: Adenosine; Analgesics, Opioid; Animals; Clonidine; Dose-Response Relationship, Drug; Fentanyl; Heroin; Hydromorphone; Infusions, Intravenous; Injections, Spinal; Male; Methadone; Morphine; Neuralgia; Pain; Rats; Rats, Inbred F344; Self Administration | 2007 |
[Adenosine for treatment of ischemic pain in thromboangiitis obliterans. A case report].
Topics: Adenosine; Adult; Analgesics; Female; Humans; Ischemia; Pain; Pain Measurement; Thromboangiitis Obliterans; Treatment Outcome | 2007 |
The antinociceptive effect of 2-chloro-2'-C-methyl-N6-cyclopentyladenosine (2'-Me-CCPA), a highly selective adenosine A1 receptor agonist, in the rat.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Analgesics; Animals; Dose-Response Relationship, Drug; Hyperalgesia; Male; Pain; Pain Threshold; Rats; Rats, Wistar | 2007 |
Antinociceptive interactions of triple and quadruple combinations of endogenous ligands at the spinal level.
Topics: Adenosine; Agmatine; Analgesics; Animals; Area Under Curve; Disease Models, Animal; Drug Combinations; Injections, Spinal; Kynurenic Acid; Ligands; Male; Motor Activity; Oligopeptides; Pain; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; Receptors, Opioid, mu; Spinal Cord | 2007 |
Expression of adenosine A 2A receptors in the rat lumbar spinal cord and implications in the modulation of N-methyl-d-aspartate receptor currents.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Animals; Blotting, Western; Glycine; Lumbosacral Region; Membrane Potentials; N-Methylaspartate; Pain; Patch-Clamp Techniques; Phenethylamines; Posterior Horn Cells; Rats; Rats, Wistar; Receptor, Adenosine A2A; Receptors, N-Methyl-D-Aspartate; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Spinal Cord; Substantia Gelatinosa | 2008 |
Antinociceptive effects in mice after intrathecal injection of 5'-N-ethylcarboxamide adenosine.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Analgesics; Animals; Injections, Spinal; Male; Mice; Pain; Reaction Time; Receptors, Cell Surface; Receptors, Purinergic; Spinal Cord | 1984 |
Theophylline-induced nociceptive behavioral response in mice: possible indirect interaction with spinal N-methyl-D-aspartate receptors.
Topics: 2-Amino-5-phosphonovalerate; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Behavior, Animal; Male; Mice; Pain; Receptors, N-Methyl-D-Aspartate; Receptors, Purinergic; Spinal Cord; Substance P; Theophylline | 1993 |
Morphine and norepinephrine-induced antinociception at the spinal level is mediated by adenosine.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Aminophylline; Animals; Female; Male; Morphine; Naloxone; Norepinephrine; Pain; Purinergic P1 Receptor Agonists; Rats; Rats, Wistar; Serotonin; Spinal Cord; Time Factors | 1994 |
Mechanical hyperalgesia in streptozotocin-diabetic rats.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenosine; Adenylate Cyclase Toxin; Animals; Diabetes Mellitus, Experimental; Dideoxyadenosine; Dinoprostone; GTP-Binding Proteins; Guanosine Diphosphate; Hyperalgesia; Indomethacin; Male; Mechanoreceptors; Pain; Pertussis Toxin; Rats; Rats, Sprague-Dawley; Sensory Thresholds; Thionucleotides; Virulence Factors, Bordetella | 1993 |
[Painful legs and involuntary movements of the toes. Indirect therapeutic role of adenosine].
Topics: Adenosine; Aged; Electric Stimulation Therapy; Female; Humans; Leg; Movement Disorders; Pain; Pain Management; Toes | 1993 |
Selective attenuation by N-0861 (N6-endonorboran-2-yl-9-methyladenine) of cardiac A1 adenosine receptor-mediated effects in humans.
Topics: Adenine; Adenosine; Aged; Coronary Circulation; Dose-Response Relationship, Drug; Female; Heart; Humans; Male; Middle Aged; Norbornanes; Pain; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1 | 1996 |
Pharmacology of the spinal adenosine receptor which mediates the antiallodynic action of intrathecal adenosine agonists.
Topics: Adenosine; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Injections, Spinal; Male; Pain; Phenethylamines; Purinergic P1 Receptor Agonists; Rats; Rats, Sprague-Dawley; Spinal Cord | 1996 |
Altered sensory behaviors in mice following manipulation of endogenous spinal adenosine neurotransmission.
Topics: Adenosine; Animals; Deoxyadenosines; Grooming; Male; Mice; Neurotransmitter Agents; Pain; Spinal Cord; Substance P; Theophylline | 1996 |
Experimental model of short-time exercise-induced preconditioning in POAD patients.
Topics: Adenosine; Adenosine Triphosphate; Aged; Blood Viscosity; Calcium; Exercise Therapy; Exercise Tolerance; Female; Hemorheology; Humans; Intermittent Claudication; Ischemic Preconditioning, Myocardial; Leg; Male; Middle Aged; Neutrophil Activation; Neutrophils; Pain; Peripheral Vascular Diseases; Physical Fitness; Walking | 1997 |
Adenosine receptors. Knockouts anxious for new therapy.
Topics: Adenosine; Animals; Caffeine; Drug Therapy; Mice; Mice, Knockout; Pain; Receptors, Purinergic P1 | 1997 |
Aggressiveness, hypoalgesia and high blood pressure in mice lacking the adenosine A2a receptor.
Topics: Adenosine; Aggression; Animals; Blood Pressure; Brain; Caffeine; Cloning, Molecular; Heart Rate; Humans; Hypertension; Male; Mice; Mice, Knockout; Molecular Sequence Data; Pain; Phenethylamines; Platelet Aggregation; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Restriction Mapping; Sequence Homology, Amino Acid | 1997 |
Adenosine in painful legs and moving toes syndrome.
Topics: Adenosine; Adult; Aged; Female; Humans; Leg; Male; Middle Aged; Neuromuscular Diseases; Nociceptors; Pain; Pain Management; Pain Threshold; Peripheral Nervous System Diseases; Reflex; Restless Legs Syndrome; Syndrome; Toes | 1994 |
Characterization of adenosine receptors mediating spinal sensory transmission related to nociceptive information in the rat.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Analgesics; Animals; Dose-Response Relationship, Drug; Female; Male; Pain; Rats; Rats, Wistar; Receptors, Purinergic P1; Reflex, Monosynaptic; Spinal Cord; Theophylline | 1997 |
Spinal effects of bicuculline: modulation of an allodynia-like state by an A1-receptor agonist, morphine, and an NMDA-receptor antagonist.
Topics: Adenosine; Animals; Bicuculline; Dose-Response Relationship, Drug; GABA Antagonists; Kynurenic Acid; Male; Morphine; Naloxone; Nerve Fibers; Neurons; Pain; Physical Stimulation; Purinergic P1 Receptor Agonists; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Touch | 1998 |
Stress-dependent antinociceptive effects of carbamazepine: a study in stressed and nonstressed rats.
Topics: Adenosine; Analgesics, Non-Narcotic; Analysis of Variance; Animals; Caffeine; Carbamazepine; Cerebral Ventricles; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Injections, Intraventricular; Male; Naloxone; Pain; Physical Stimulation; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Restraint, Physical; Stress, Psychological; Time Factors | 1998 |
Intrathecal administration of the adenosine A1 receptor agonist R-phenylisopropyl adenosine reduces presumed pain behaviour in a rat model of central pain.
Topics: Adenosine; Animals; Behavior, Animal; Cold Temperature; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Injections, Spinal; Nociceptors; Pain; Physical Stimulation; Purinergic P1 Receptor Agonists; Rats; Rats, Sprague-Dawley; Spinal Cord; Spinal Cord Injuries; Vasodilator Agents | 1998 |
Modulation of spinal pain mechanisms by spinal cord stimulation and the potential role of adjuvant pharmacotherapy.
Topics: Adenosine; Animals; Baclofen; Behavior, Animal; Chemotherapy, Adjuvant; Combined Modality Therapy; Disease Models, Animal; Electric Stimulation Therapy; GABA Antagonists; gamma-Aminobutyric Acid; Humans; Injections, Spinal; Male; Pain; Pain Management; Pain Threshold; Peripheral Nervous System Diseases; Rats; Rats, Sprague-Dawley; Receptors, GABA; Receptors, Purinergic P1; Spinal Cord; Touch; Treatment Outcome | 1997 |
Inhibition of strychnine-allodynia is mediated by spinal adenosine A1- but not A2-receptors in the rat.
Topics: Adenosine; Animals; Blood Pressure; Caffeine; Heart Rate; Injections, Spinal; Male; Pain; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Spinal Cord; Strychnine; Xanthines | 1998 |
Reduced anti-allodynic effect of the adenosine A1-receptor agonist R-phenylisopropyladenosine on repeated intrathecal administration and lack of cross-tolerance with morphine in a rat model of central pain.
Topics: Adenosine; Analgesics; Analgesics, Opioid; Animals; Chronic Disease; Drug Tolerance; Female; Injections, Spinal; Morphine; Pain; Purinergic P1 Receptor Agonists; Rats; Rats, Sprague-Dawley; Spinal Cord Injuries | 1998 |
Pain analysis in prediction of treatment outcome.
Topics: Adenosine; Analgesics; Analgesics, Opioid; Anesthetics, Local; Dose-Response Relationship, Drug; Drug Administration Schedule; Forecasting; Humans; Infusions, Intravenous; Injections, Intravenous; Lidocaine; Naloxone; Narcotic Antagonists; Nociceptors; Pain; Pain Measurement; Phentolamine; Receptors, N-Methyl-D-Aspartate; Reflex Sympathetic Dystrophy; Sympatholytics; Treatment Outcome | 1998 |
Exogenous and endogenous adenosine enhance the spinal antiallodynic effects of morphine in a rat model of neuropathic pain.
Topics: Adenosine; Analgesics, Opioid; Animals; Deoxyadenosines; Dipyridamole; Drug Synergism; Injections, Spinal; Ligation; Male; Morphine; Neuritis; Pain; Pain Measurement; Physical Stimulation; Purinergic P1 Receptor Agonists; Rats; Rats, Sprague-Dawley; Spinal Nerves | 1999 |
Peripheral antinociceptive action of amitriptyline in the rat formalin test: involvement of adenosine.
Topics: Adenosine; Amitriptyline; Analgesics; Animals; Antidepressive Agents, Tricyclic; Caffeine; Dose-Response Relationship, Drug; Male; Pain; Pain Measurement; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha; Receptors, Glutamate; Receptors, Histamine; Receptors, Opioid | 1999 |
Endogenous adenosine involved in the mediation of spinal antinociception produced by stimulating locus coeruleus.
Topics: Adenosine; Aminophylline; Animals; Electric Stimulation; Female; Locus Coeruleus; Male; Pain; Phentolamine; Purinergic P1 Receptor Agonists; Rats; Rats, Wistar; Receptors, Purinergic P1; Spinal Cord; Sympatholytics | 1999 |
Intrathecal adenosine interacts with a spinal noradrenergic system to produce antinociception in nerve-injured rats.
Topics: Adenosine; Analgesics; Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Injections, Spinal; Ligation; Male; Nociceptors; Norepinephrine; Pain; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Spinal Cord; Spinal Nerve Roots | 1999 |
Intrathecal adenosine does not relieve allodynia-like behavior in spinally injured rats.
Topics: Adenosine; Animals; Behavior, Animal; Female; Injections, Spinal; Motor Activity; Neuroprotective Agents; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Spinal Cord; Spinal Cord Injuries | 1999 |
Capsaicin sensitivity and voltage-gated sodium currents in colon sensory neurons from rat dorsal root ganglia.
Topics: Action Potentials; Adenosine; Analgesics; Animals; Bradykinin; Capsaicin; Carbocyanines; Colon; Dinoprostone; Dose-Response Relationship, Drug; Electrophysiology; Fluorescent Dyes; Ganglia, Spinal; Histamine; Ion Channel Gating; Male; Neurons, Afferent; Pain; Rats; Rats, Sprague-Dawley; Serotonin; Sodium; Sodium Channels; Tetrodotoxin | 1999 |
Chronic hypersensitivity for inflammatory nociceptor sensitization mediated by the epsilon isozyme of protein kinase C.
Topics: Adenosine; Animals; Carrageenan; Dinoprostone; Enzyme Inhibitors; Hindlimb; Hyperalgesia; Inflammation; Isoenzymes; Male; Nociceptors; Pain; Phenethylamines; Protein Kinase C; Protein Kinase C-epsilon; Protein Kinase Inhibitors; Purinergic P1 Receptor Agonists; Rats; Rats, Sprague-Dawley; Serotonin; Time Factors | 2000 |
Complete inhibition of purinoceptor agonist-induced nociception by spinorphin, but not by morphine.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Adenosine; Analgesics, Opioid; Animals; Animals, Newborn; Bradykinin; Capsaicin; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Male; Mice; Morphine; Neurons, Afferent; Neuroprotective Agents; Oligopeptides; Pain; Pertussis Toxin; Piperidines; Protease Inhibitors; Purinergic Agonists; Thionucleosides; Time Factors; Virulence Factors, Bordetella | 2000 |
Allosteric adenosine modulation to reduce allodynia.
Topics: Adenosine; Animals; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Injections, Spinal; Male; Pain; Pain Measurement; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Spinal Nerves; Xanthines | 2001 |
Systemic adenosine infusions alleviated neuropathic pain.
Topics: Adenosine; Adolescent; Analgesics; Humans; Infusions, Intravenous; Male; Metabolic Diseases; Pain | 2001 |
The pathophysiology of cardiac syndrome X--a tale of paradigm shifts.
Topics: 3-Iodobenzylguanidine; Adenosine; Coronary Disease; Dipyridamole; Heart Rate; Humans; Microvascular Angina; Pain; Pain Threshold; Sympathetic Nervous System | 2001 |
Intrathecal adenosine following spinal nerve ligation in rat: short residence time in cerebrospinal fluid and no change in A(1) receptor binding.
Topics: Adenosine; Analgesics; Animals; Injections, Spinal; Ligation; Male; Microdialysis; Pain; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Spinal Nerves; Xanthines | 2002 |
ATP-sensitive potassium channels and endogenous adenosine are involved in spinal antinociception produced by locus coeruleus stimulation.
Topics: Adenosine; Adenosine Triphosphate; Animals; Electric Stimulation; Female; Injections, Spinal; Locus Coeruleus; Male; Pain; Potassium Channels; Rats; Rats, Wistar | 2002 |
Adenosine receptor-mediated control of in vitro release of pain-related neuropeptides from the rat spinal cord.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Calcitonin Gene-Related Peptide; Cholecystokinin; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Neuropeptides; Pain; Phenethylamines; Potassium; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Spinal Cord; Substance P; Xanthines | 2002 |
Biopsy evidence of left ventricular myocardial abnormality in patients with mitral-leaflet prolapse and chest pain.
Topics: Adenosine; Adenosine Triphosphatases; Adult; Female; Heart Ventricles; Histocytochemistry; Humans; Male; Middle Aged; Mitral Valve Prolapse; Monoamine Oxidase; Myocardium; Pain; Succinate Dehydrogenase; Succinates; Thorax | 1979 |
Observations on the algogenic actions of adenosine compounds on the human blister base preparation.
Topics: Adenine Nucleotides; Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Blister; Calcium; Cyclic AMP; Humans; Jejunum; Muscle Tonus; Nerve Endings; Pain; Potassium; Rabbits; Skin | 1977 |
Mediation of serotonin hyperalgesia by the cAMP second messenger system.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenosine; Analgesics; Animals; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guanosine 5'-O-(3-Thiotriphosphate); Hyperalgesia; Isomerism; Male; Nociceptors; Pain; Protein Kinase Inhibitors; Pyrrolidines; Pyrrolidinones; Rats; Rats, Inbred Strains; Receptors, Serotonin; Rolipram; Second Messenger Systems; Serotonin; Tetrahydronaphthalenes | 1992 |
Allodynia evoked by intrathecal administration of prostaglandin F2 alpha to conscious mice.
Topics: Adenosine; Animals; Behavior, Animal; Dinoprost; Dose-Response Relationship, Drug; Injections, Spinal; Male; Mice; Mice, Inbred Strains; Pain; Reaction Time; Sympathomimetics | 1992 |
Peripheral vibration causes an adenosine-mediated postsynaptic inhibitory potential in dorsal horn neurons of the cat spinal cord.
Topics: Adenosine; Adenosine Monophosphate; Animals; Bicuculline; Cats; Evoked Potentials; Iontophoresis; Membrane Potentials; Naloxone; Neurons; Pain; Physical Stimulation; Purinergic Antagonists; Spinal Cord; Strychnine; Synapses; Theophylline; Vibration | 1992 |
Adenosine does not evoke pain from venous and paravascular nociceptors in the human.
Topics: Adenosine; Blood Vessels; Electric Stimulation; Hand; Humans; Injections; Male; Nociceptors; Pain; Perfusion | 1992 |
Nicotine enhances angina pectoris-like chest pain and atrioventricular blockade provoked by intravenous bolus of adenosine in healthy volunteers.
Topics: Adenosine; Adult; Angina Pectoris; Drug Synergism; Electrocardiography; Female; Heart Block; Heart Rate; Humans; Male; Middle Aged; Nicotine; Pain | 1990 |
Thallium-201 scintigraphy after intravenous infusion of adenosine compared with exercise thallium testing in the diagnosis of coronary artery disease.
Topics: Adenosine; Adult; Coronary Disease; Electrocardiography; Exercise Test; Female; Heart Conduction System; Hemodynamics; Humans; Infusions, Intravenous; Male; Middle Aged; Pain; Thallium Radioisotopes; Thorax; Tomography, Emission-Computed, Single-Photon | 1991 |
Adenosine mediates calcium-induced antinociception and potentiation of noradrenergic antinociception in the spinal cord.
Topics: 5,7-Dihydroxytryptamine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Calcium; Drug Synergism; Hot Temperature; Hydroxydopamines; Male; Methysergide; Norepinephrine; Oxidopamine; Pain; Phentolamine; Rats; Rats, Inbred Strains; Receptors, Purinergic; Serotonin; Spinal Cord; Theophylline | 1990 |
Antinociception produced by interactions between intrathecally administered adenosine agonists and norepinephrine.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Analgesics; Animals; Blood Pressure; Dose-Response Relationship, Drug; Drug Interactions; Male; Norepinephrine; Pain; Rats; Rats, Inbred Strains; Receptors, Purinergic; Spinal Cord | 1990 |
Diagnosis of coronary artery disease by controlled coronary vasodilation with adenosine and thallium-201 scintigraphy in patients unable to exercise.
Topics: Adenosine; Adult; Aged; Aged, 80 and over; Angiography; Coronary Angiography; Coronary Disease; Coronary Vessels; Electrocardiography; Exercise; Female; Hemodynamics; Humans; Jaw; Male; Middle Aged; Pain; Pharynx; Radionuclide Imaging; Thallium Radioisotopes; Thorax; Vasodilation | 1990 |
Antinociceptive interactions between intrathecally administered alpha noradrenergic agonists and 5'-N-ethylcarboxamide adenosine.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Analgesia; Animals; Blood Pressure; Clonidine; Dose-Response Relationship, Drug; Drug Interactions; Hot Temperature; Injections, Spinal; Male; Norepinephrine; Pain; Phenylephrine; Rats; Rats, Inbred Strains; Spinal Cord; Vasodilator Agents | 1990 |
Behavior induced by putative nociceptive neurotransmitters is inhibited by adenosine or adenosine analogs coadministered intrathecally.
Topics: Adenosine; Animals; Aspartic Acid; Behavior, Animal; Excitatory Amino Acid Antagonists; Glutamic Acid; Injections, Spinal; Male; Mice; N-Methylaspartate; Neurotransmitter Agents; Pain; Substance P | 1988 |
Assessment of the role of A1/A2 adenosine receptors mediating the purine antinociception, motor and autonomic function in the rat spinal cord.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Autonomic Nervous System; Blood Pressure; Caffeine; Male; Movement; Pain; Phenylisopropyladenosine; Rats; Rats, Inbred Strains; Receptors, Purinergic; Spinal Cord; Urinary Bladder | 1989 |
Classification of adenosine receptors mediating antinociception in the rat spinal cord.
Topics: 2-Chloroadenosine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Dose-Response Relationship, Drug; Male; Pain; Phenylisopropyladenosine; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Purinergic; Spinal Cord; Theophylline | 1986 |
Action of peptides and other algesic agents on paravascular pain receptors of the isolated perfused rabbit ear.
Topics: Acetylcholine; Action Potentials; Adenosine; Adenosine Triphosphate; Angiotensin II; Animals; Blood Pressure; Drug Synergism; Ear; Eledoisin; Epinephrine; Female; Histamine; In Vitro Techniques; Male; Oxytocin; Pain; Peptides; Potassium Chloride; Prostaglandins; Rabbits; Respiration; Sensory Receptor Cells; Serotonin; Substance P; Time Factors; Vasoconstrictor Agents; Vasodilator Agents; Vasopressins; Venous Pressure | 1974 |