acetaldehyde and Esophageal Squamous Cell Carcinoma
acetaldehyde has been researched along with Esophageal Squamous Cell Carcinoma in 6 studies
Acetaldehyde: A colorless, flammable liquid used in the manufacture of acetic acid, perfumes, and flavors. It is also an intermediate in the metabolism of alcohol. It has a general narcotic action and also causes irritation of mucous membranes. Large doses may cause death from respiratory paralysis.
acetaldehyde : The aldehyde formed from acetic acid by reduction of the carboxy group. It is the most abundant carcinogen in tobacco smoke.
aldehyde : A compound RC(=O)H, in which a carbonyl group is bonded to one hydrogen atom and to one R group.
acetyl group : A group, formally derived from acetic acid by dehydroxylation, which is fundamental to the biochemistry of all forms of life. When bound to coenzyme A, it is central to the metabolism of carbohydrates and fats.
Esophageal Squamous Cell Carcinoma: A carcinoma that originates usually from cells on the surface of the middle and lower third of the ESOPHAGUS. Tumor cells exhibit typical squamous morphology and form large polypoid lesions. Mutations in RNF6, LZTS1, TGFBR2, DEC1, and WWOX1 genes are associated with this cancer.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "Patients with inactive acetaldehyde dehydrogenase 2 (ALDH2) are at high risk for esophageal squamous cell carcinoma (ESCC) and hypopharyngeal squamous cell carcinoma (HPSCC)." | 5.41 | Acetaldehyde breath test as a cancer risk marker in patients with esophageal and hypopharyngeal squamous cell carcinoma. ( Arima, S; Fujita, H; Hashimoto, S; Ido, A; Iwaya, H; Kabayama, M; Kanmura, S; Komaki, Y; Maeda, H; Oda, K; Sasaki, F; Tanoue, S, 2021) |
| "The acetaldehyde-to-ethanol ratio detected using the acetaldehyde breath test could be a novel biomarker of metachronous recurrence after endoscopic submucosal dissection in patients with esophageal squamous cell carcinoma and hypopharynx squamous cell carcinoma." | 4.31 | Usefulness of the aldehyde breath test for predicting metachronous recurrence in patients with esophageal squamous cell carcinoma and hypopharyngeal squamous cell carcinoma. ( Arima, S; Hashimoto, S; Ido, A; Kanmura, S; Kumagai, K; Maeda, H; Mawatari, S; Oda, K; Sasaki, F; Tanaka, A; Tanoue, S; Yano, H, 2023) |
| "Alcohol consumption is the key risk factor for the development of esophageal squamous cell carcinoma (ESCC), and acetaldehyde, a metabolite of alcohol, is an alcohol-derived major carcinogen that causes DNA damage." | 3.96 | Protective effects of Alda-1, an ALDH2 activator, on alcohol-derived DNA damage in the esophagus of human ALDH2*2 (Glu504Lys) knock-in mice. ( Amanuma, Y; Baba, K; Hirohashi, K; Ida, T; Kikuchi, O; Matsubara, J; Matsuda, T; Mitani, Y; Miyamoto, S; Mizumoto, A; Muto, M; Nakai, Y; Ohashi, S; Seno, H; Yamada, A; Yamamoto, Y, 2020) |
| "Esophageal squamous cell carcinoma (ESCC) accounts for the large majority of esophageal cancer cases worldwide." | 2.82 | Non-Acid Fluid Exposure and Esophageal Squamous Cell Carcinoma. ( Abrams, JA; Etemadi, A; Soroush, A, 2022) |
| "Patients with esophageal squamous cell carcinoma (ESCC) might have a specific mechanism for the carcinogenesis by alcohol consumption in the background esophageal mucosa, and nuclear factor erythroid 2-related factor 2 (NRF2), which plays a protective role against esophageal carcinogenesis, and barrier dysfunction might be associated with this phenomenon." | 1.72 | Decreased Expression of NRF2 Target Genes after Alcohol Exposure in the Background Esophageal Mucosa of Patients with Esophageal Squamous Cell Carcinoma. ( Abe, H; Asano, N; Asanuma, K; Hamada, S; Hatta, W; Imatani, A; Jin, X; Kanno, T; Koike, T; Masamune, A; Nakamura, T; Nakaya, N; Ogata, Y; Ono, Y; Saito, M; Toda, S; Uno, K, 2022) |
Research
Studies (6)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 5 (83.33) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Toda, S | 1 |
| Hatta, W | 1 |
| Asanuma, K | 1 |
| Asano, N | 1 |
| Ono, Y | 1 |
| Abe, H | 1 |
| Ogata, Y | 1 |
| Saito, M | 1 |
| Kanno, T | 1 |
| Jin, X | 1 |
| Uno, K | 1 |
| Koike, T | 1 |
| Imatani, A | 1 |
| Hamada, S | 1 |
| Nakamura, T | 1 |
| Nakaya, N | 1 |
| Masamune, A | 1 |
| Sasaki, F | 2 |
| Mawatari, S | 1 |
| Oda, K | 2 |
| Yano, H | 1 |
| Maeda, H | 2 |
| Tanaka, A | 1 |
| Arima, S | 2 |
| Kumagai, K | 1 |
| Tanoue, S | 2 |
| Hashimoto, S | 2 |
| Kanmura, S | 2 |
| Ido, A | 2 |
| Kabayama, M | 1 |
| Iwaya, H | 1 |
| Komaki, Y | 1 |
| Fujita, H | 1 |
| Soroush, A | 1 |
| Etemadi, A | 1 |
| Abrams, JA | 1 |
| Matejcic, M | 1 |
| Gunter, MJ | 1 |
| Ferrari, P | 1 |
| Hirohashi, K | 1 |
| Ohashi, S | 1 |
| Amanuma, Y | 1 |
| Nakai, Y | 1 |
| Ida, T | 1 |
| Baba, K | 1 |
| Mitani, Y | 1 |
| Mizumoto, A | 1 |
| Yamamoto, Y | 1 |
| Kikuchi, O | 1 |
| Matsubara, J | 1 |
| Yamada, A | 1 |
| Miyamoto, S | 1 |
| Seno, H | 1 |
| Matsuda, T | 1 |
| Muto, M | 1 |
Reviews
2 reviews available for acetaldehyde and Esophageal Squamous Cell Carcinoma
| Article | Year |
|---|---|
Non-Acid Fluid Exposure and Esophageal Squamous Cell Carcinoma.
Topics: Acetaldehyde; Animals; Carcinoma, Squamous Cell; Esophageal Neoplasms; Esophageal Squamous Cell Carc | 2022 |
Alcohol metabolism and oesophageal cancer: a systematic review of the evidence.
Topics: Acetaldehyde; Alcohol Dehydrogenase; Alcohol Drinking; Biomarkers, Tumor; Carcinoma, Squamous Cell; | 2017 |
Trials
1 trial available for acetaldehyde and Esophageal Squamous Cell Carcinoma
| Article | Year |
|---|---|
Acetaldehyde breath test as a cancer risk marker in patients with esophageal and hypopharyngeal squamous cell carcinoma.
Topics: Acetaldehyde; Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Breath Tests; Carcinoma, Squamous C | 2021 |
Other Studies
3 other studies available for acetaldehyde and Esophageal Squamous Cell Carcinoma
| Article | Year |
|---|---|
Decreased Expression of NRF2 Target Genes after Alcohol Exposure in the Background Esophageal Mucosa of Patients with Esophageal Squamous Cell Carcinoma.
Topics: Acetaldehyde; Aldehyde Dehydrogenase, Mitochondrial; Carcinogenesis; Carcinoma, Squamous Cell; Claud | 2022 |
Usefulness of the aldehyde breath test for predicting metachronous recurrence in patients with esophageal squamous cell carcinoma and hypopharyngeal squamous cell carcinoma.
Topics: Acetaldehyde; Aldehydes; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Ethanol; Head and | 2023 |
Protective effects of Alda-1, an ALDH2 activator, on alcohol-derived DNA damage in the esophagus of human ALDH2*2 (Glu504Lys) knock-in mice.
Topics: Acetaldehyde; Alcohol Drinking; Aldehyde Dehydrogenase, Mitochondrial; Animals; Benzamides; Benzodio | 2020 |