Page last updated: 2024-08-24

zileuton and mk 0591

zileuton has been researched along with mk 0591 in 8 studies

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's5 (62.50)18.2507
2000's0 (0.00)29.6817
2010's3 (37.50)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Brideau, C; Chan, CC; Dubé, D; Ducharme, Y; Falgueyret, JP; Gillard, JW; Guay, J; Hutchinson, JH; McFarlane, CS; Riendeau, D1
Brideau, C; Chan, C; Falgueyret, JP; Guay, J; Hutchinson, JH; Jones, TR; Lépine, C; Macdonald, D; McFarlane, CS; Riendeau, D1
Brideau, C; Chan, CC; Chauret, N; Delorme, D; Desmarais, S; Dubé, D; Ducharme, Y; Falgueyret, JP; Fortin, R; Girard, Y; Guay, J; Hamel, P; Jones, TR; Lépine, C; Li, C; McAuliffe, M; McFarlane, CS; Nicoll-Griffith, DA; Riendeau, D; Yergey, JA1
Brideau, C; Chan, CC; Delorme, D; Desmarais, S; Dubé, D; Ducharme, Y; Ethier, D; Falgueyret, JP; Girard, Y; Grimm, E; Guay, J; Hamel, P; Jones, TR; Kwong, E; McAuliffe, M; McFarlane, CS; Piechuta, H; Riendeau, D; Roumi, M; Tagari, P; Young, RN1
Singh, P1
Prasher, P; Singh, P1
Bhatti, R; Dhillon, P; Prasher, P; Singh, P1
Black, C; Brideau, C; Chan, C; Ford-Hutchinson, A; Frenette, R; Tagari, P1

Other Studies

8 other study(ies) available for zileuton and mk 0591

ArticleYear
Naphthalenic lignan lactones as selective, nonredox 5-lipoxygenase inhibitors. Synthesis and biological activity of (methoxyalkyl)thiazole and methoxytetrahydropyran hybrids.
    Journal of medicinal chemistry, 1994, Feb-18, Volume: 37, Issue:4

    Topics: Animals; Benzofurans; Humans; Lactones; Lipoxygenase; Lipoxygenase Inhibitors; Male; Naphthalenes; Neutrophils; Pyrans; Rats; Rats, Sprague-Dawley; Saimiri; Structure-Activity Relationship; Thiazoles

1994
Thiopyrano[2,3,4-cd]indoles as 5-lipoxygenase inhibitors: synthesis, biological profile, and resolution of 2-[2-[1-(4-chlorobenzyl)-4-methyl-6-[(5-phenylpyridin-2-yl)methoxy]-4,5 -dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]ethoxy]butanoic acid.
    Journal of medicinal chemistry, 1994, Apr-15, Volume: 37, Issue:8

    Topics: Animals; Bronchoconstriction; Calcimycin; Chromatography, High Pressure Liquid; Humans; Indoles; Leukotriene B4; Leukotrienes; Lipoxygenase Inhibitors; Male; Molecular Structure; Pyridines; Rats; Rats, Sprague-Dawley; Saimiri; Sheep; Stereoisomerism; Structure-Activity Relationship; Swine

1994
Dioxabicyclooctanyl naphthalenenitriles as nonredox 5-lipoxygenase inhibitors: structure-activity relationship study directed toward the improvement of metabolic stability.
    Journal of medicinal chemistry, 1996, Sep-27, Volume: 39, Issue:20

    Topics: Animals; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Benzofurans; Bronchoconstriction; Drug Stability; Humans; Leukotriene B4; Leukotrienes; Lipoxygenase Inhibitors; Male; Microsomes, Liver; Molecular Structure; Naphthalenes; Neutrophils; Nitriles; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Saimiri; Structure-Activity Relationship

1996
Substituted (pyridylmethoxy)naphthalenes as potent and orally active 5-lipoxygenase inhibitors; synthesis, biological profile, and pharmacokinetics of L-739,010.
    Journal of medicinal chemistry, 1997, Aug-29, Volume: 40, Issue:18

    Topics: Animals; Ascaris; Biological Availability; Bronchodilator Agents; Dogs; Dyspnea; Humans; Inflammation; Lipoxygenase Inhibitors; Magnetic Resonance Spectroscopy; Male; Molecular Conformation; Molecular Structure; Naphthalenes; Nematode Infections; Pyridines; Rats; Recombinant Proteins; Saimiri; Sheep; Spodoptera; Transfection

1997
N-1, C-3 substituted indoles as 5-LOX inhibitors--in vitro enzyme immunoaasay, mass spectral and molecular docking investigations.
    Bioorganic & medicinal chemistry letters, 2013, Mar-01, Volume: 23, Issue:5

    Topics: Immunoenzyme Techniques; Indoles; Lipoxygenase Inhibitors; Mass Spectrometry; Models, Molecular; Molecular Docking Simulation; Structure-Activity Relationship

2013
Lead modification: amino acid appended indoles as highly effective 5-LOX inhibitors.
    Bioorganic & medicinal chemistry, 2014, Mar-01, Volume: 22, Issue:5

    Topics: Amino Acids; Indoles; Lipoxygenase Inhibitors; Models, Molecular; Molecular Docking Simulation; Structure-Activity Relationship

2014
Indole based peptidomimetics as anti-inflammatory and anti-hyperalgesic agents: Dual inhibition of 5-LOX and COX-2 enzymes.
    European journal of medicinal chemistry, 2015, Jun-05, Volume: 97

    Topics: Animals; Anti-Inflammatory Agents; Catalytic Domain; Crystallography, X-Ray; Cyclooxygenase 2 Inhibitors; Hyperalgesia; Indoles; Inhibitory Concentration 50; Lipoxygenase Inhibitors; Mice; Molecular Docking Simulation; Molecular Structure; Peptidomimetics

2015
Assessment of the in vivo biochemical efficacy of orally active leukotriene biosynthesis inhibitors.
    Agents and actions, 1993, Volume: 40, Issue:1-2

    Topics: Animals; Calcimycin; Chromatography, High Pressure Liquid; Depression, Chemical; Dogs; Dose-Response Relationship, Drug; Hydroxyurea; Indoles; Leukotriene Antagonists; Leukotriene E4; Leukotrienes; Lipoxygenase Inhibitors; Male; Quinolines

1993