Page last updated: 2024-08-23

zidovudine and uracil

zidovudine has been researched along with uracil in 26 studies

Research

Studies (26)

TimeframeStudies, this research(%)All Research%
pre-19901 (3.85)18.7374
1990's16 (61.54)18.2507
2000's7 (26.92)29.6817
2010's2 (7.69)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Anné, J; de Clercq, E; de Vreese, K; Debyser, Z; Desmyter, J; Pauwels, R; Vandamme, AM1
Baba, M; De Clercq, E; Debyser, Z; Desmyter, J; Pauwels, R1
Baba, M; De Clercq, E; Ito, M; Miyasaka, T; Shigeta, S; Tanaka, H; Ubasawa, M; Umezu, K; Walker, RT1
Calabresi, P; Chu, SH; Darnowski, JW; Falcone, A; St Clair, MH; Wiemann, MC1
Brunetti, I; Calabresi, P; Chu, SH; Darnowski, JW; Falcone, A; Ruprecht, RM1
Broder, S; Mitsuya, H; Webb, TR1
Allegra, CJ; Grogan, L; Sotos, GA1
Baba, M; De Clercq, E; Miyasaka, T; Sekiya, K; Shigeta, S; Takashima, H; Tanaka, H; Ubasawa, M; Walker, RT; Yuasa, S1
Henson, E; McClarty, G; Wang, LL1
Bader, JP; Boyer, PL; Buckheit, RW; Chu, SH; Fliakas-Boltz, V; Hughes, SH; Mayers, DL; Pan, BC; Weislow, O; Yeagy-Bargo, S1
Brennan, TM; Bridges, CG; Leyda, JP; Taylor, DL; Tyms, AS1
Baba, M; Inouye, N; Sadakata, Y; Sekiya, K; Takashima, H; Ubasawa, M; Yuasa, S1
Goudgaon, NM; McKenna, PM; Mellors, JW; Nguyen, MH; Schinazi, RF; Shi, C1
Baba, M; Makino, M; Nakade, K; Okamoto, M; Yamada, K; Yuasa, S1
Baba, M; Fujiwara, M; Ijichi, K; Konno, K; Machida, H; Mori, K; Morozumi, M; Shigeta, S; Yokota, T1
Baba, M; Fujiwara, M; Ijichi, K; Konno, K; Shigeta, S; Yokota, T1
Baba, M; Nakade, K; Piras, G; Yuasa, S1
Aubertin, AM; Bisagni, E; Dechaux, E; Dollé, V; Grierson, DS; Guillaumel, J; Legraverend, M; Monneret, C; Nguyen, CH; Note, R; Pontikis, R1
Andrzejewska, M; Górska, A; Kamiński, J; Kazimierezuk, Z1
Agelis, G; Botić, T; Cencic, A; Dolinsek, J; Komiotis, D; Tsoukala, E1
Danel, K; La Colla, P; Larsen, LM; Loddo, R; Pedersen, EB; Sanna, G1
Iams, TA; McKee, EE; Morris, GW; Slepchenko, KG1
Saada, A1
Hattori, T; Kodama, EN; Li, S1

Reviews

1 review(s) available for zidovudine and uracil

ArticleYear
Preclinical and clinical aspects of biomodulation of 5-fluorouracil.
    Cancer treatment reviews, 1994, Volume: 20, Issue:1

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Cisplatin; Colorectal Neoplasms; DNA, Neoplasm; Fluorouracil; Humans; Idoxuridine; Immunologic Factors; Interferons; Leucovorin; Methotrexate; Mice; Phosphonoacetic Acid; RNA, Neoplasm; Uracil; Uridine; Zidovudine

1994

Other Studies

25 other study(ies) available for zidovudine and uracil

ArticleYear
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.
    Bioorganic & medicinal chemistry, 2009, Oct-01, Volume: 17, Issue:19

    Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Resistance of human immunodeficiency virus type 1 reverse transcriptase to TIBO derivatives induced by site-directed mutagenesis.
    Virology, 1992, Volume: 188, Issue:2

    Topics: Antiviral Agents; Base Sequence; Benzodiazepines; Binding Sites; Deoxyguanine Nucleotides; Dideoxynucleotides; HIV Reverse Transcriptase; HIV-1; Imidazoles; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Structure-Activity Relationship; Uracil; Zidovudine

1992
Common features in the interaction of tetrahydroimidazo[4,5,1-jk][1,4]benzodiazepin-2(1H)-one and -thione and 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine derivatives with the human immunodeficiency virus type 1 reverse transcriptase.
    Molecular pharmacology, 1992, Volume: 41, Issue:5

    Topics: Antiviral Agents; Benzodiazepines; Dideoxynucleotides; HIV-1; Imidazoles; Kinetics; Molecular Structure; Recombinant Proteins; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Templates, Genetic; Thymidine; Thymine Nucleotides; Uracil; Zidovudine

1992
Synergistic inhibition of human immunodeficiency virus type 1 replication by 5-ethyl-1-ethoxymethyl-6-(phenylthio)uracil (E-EPU) and azidothymidine in vitro.
    Antimicrobial agents and chemotherapy, 1991, Volume: 35, Issue:7

    Topics: Antiviral Agents; Cells, Cultured; Cytopathogenic Effect, Viral; Drug Synergism; HIV-1; Humans; Uracil; Virus Replication; Zidovudine

1991
Benzylacyclouridine reverses azidothymidine-induced marrow suppression without impairment of anti-human immunodeficiency virus activity.
    Blood, 1990, Dec-01, Volume: 76, Issue:11

    Topics: Anemia; Animals; Cell Line; Cytopathogenic Effect, Viral; Female; HIV; Leukopenia; Mice; Mice, Inbred BALB C; Uracil; Uridine; Zidovudine

1990
Different effect of benzylacyclouridine on the toxic and therapeutic effects of azidothymidine in mice.
    Blood, 1990, Dec-01, Volume: 76, Issue:11

    Topics: Acquired Immunodeficiency Syndrome; Anemia; Animals; Dose-Response Relationship, Drug; Female; Kinetics; Leukemia, Experimental; Leukopenia; Mice; Mice, Inbred BALB C; Rauscher Virus; Uracil; Uridine; Zidovudine

1990
1-(2,3-Anhydro-beta-D-lyxofuranosyl)cytosine derivatives as potential inhibitors of the human immunodeficiency virus.
    Journal of medicinal chemistry, 1988, Volume: 31, Issue:7

    Topics: Ancitabine; Chemical Phenomena; Chemistry; Cytarabine; Cytidine; HIV; Magnetic Resonance Spectroscopy; Mass Spectrometry; Thymidine; Uracil; Zidovudine

1988
Preclinical evaluation of MKC-442, a highly potent and specific inhibitor of human immunodeficiency virus type 1 in vitro.
    Antimicrobial agents and chemotherapy, 1994, Volume: 38, Issue:4

    Topics: Antiviral Agents; Cells, Cultured; Drug Evaluation, Preclinical; Drug Resistance, Microbial; Drug Synergism; HIV Reverse Transcriptase; HIV-1; HIV-2; Humans; Reverse Transcriptase Inhibitors; Uracil; Virus Replication; Zidovudine

1994
Characterization of trimethoprim- and sulphisoxazole-resistant Chlamydia trachomatis.
    Molecular microbiology, 1994, Volume: 14, Issue:2

    Topics: Adenosine Triphosphate; Animals; Chlamydia trachomatis; DNA, Bacterial; Drug Resistance, Microbial; Fluorouracil; Guanosine Triphosphate; L Cells; Methotrexate; Mice; Microbial Sensitivity Tests; Mutation; Phenotype; RNA, Bacterial; Sulfisoxazole; Thymidine; Trimethoprim; Uracil; Zidovudine

1994
Resistance to 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine derivatives is generated by mutations at multiple sites in the HIV-1 reverse transcriptase.
    Virology, 1995, Jun-20, Volume: 210, Issue:1

    Topics: Antiviral Agents; Cell Line; Dose-Response Relationship, Drug; Drug Resistance, Microbial; HIV Reverse Transcriptase; HIV-1; HIV-2; Humans; Mutagenesis, Site-Directed; Nevirapine; Pyridines; Recombinant Proteins; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Structure-Activity Relationship; Thymine; Uracil; Zidovudine

1995
The inhibition of human immunodeficiency virus type 1 in vitro by a non-nucleoside reverse transcriptase inhibitor MKC-442, alone and in combination with other anti-HIV compounds.
    Antiviral research, 1995, Volume: 26, Issue:2

    Topics: Antiviral Agents; Cells, Cultured; Cytotoxicity Tests, Immunologic; Didanosine; Drug Interactions; HIV Reverse Transcriptase; HIV-1; Humans; Indolizines; Isoquinolines; Leukocytes, Mononuclear; Molecular Structure; Nevirapine; Pyridines; Quinolines; Reverse Transcriptase Inhibitors; Saquinavir; Uracil; Zalcitabine; Zidovudine

1995
Selective and synergistic inhibition of human immunodeficiency virus type 1 reverse transcriptase by a non-nucleoside inhibitor, MKC-442.
    Molecular pharmacology, 1993, Volume: 44, Issue:4

    Topics: Antiviral Agents; Dideoxynucleotides; Drug Synergism; HIV Reverse Transcriptase; HIV-1; Kinetics; Reverse Transcriptase Inhibitors; Thymine Nucleotides; Uracil; Virus Replication; Zidovudine

1993
Resistance of human immunodeficiency virus type 1 to acyclic 6-phenylselenenyl- and 6-phenylthiopyrimidines.
    Antimicrobial agents and chemotherapy, 1994, Volume: 38, Issue:10

    Topics: Antiviral Agents; Drug Resistance; HIV-1; Humans; Mutation; Organoselenium Compounds; Structure-Activity Relationship; Uracil; Zidovudine

1994
Complete inhibition of viral breakthrough by combination of MKC-442 with AZT during a long-term culture of HIV-1 infected cells.
    Antiviral research, 1996, Volume: 31, Issue:1-2

    Topics: Acetamides; Acetophenones; Cell Line, Transformed; HIV; HIV Core Protein p24; HIV-1; Humans; Nevirapine; Pyridines; Reverse Transcriptase Inhibitors; Uracil; Zidovudine

1996
Antiviral activities of nucleotide heterodimers against human immunodeficiency virus type 1 in vitro.
    Antiviral research, 1996, Volume: 31, Issue:1-2

    Topics: Anti-HIV Agents; Cell Line, Transformed; Cytopathogenic Effect, Viral; Didanosine; HIV-1; Humans; Ribavirin; Uracil; Zidovudine

1996
Different properties of wild type and drug-resistant mutants of human immunodeficiency virus type 1 reverse transcriptase in vitro.
    Microbiology and immunology, 1996, Volume: 40, Issue:5

    Topics: Antiviral Agents; Cells, Cultured; DNA, Viral; Drug Resistance, Microbial; HIV Infections; HIV-1; Humans; Mutation; Proviruses; RNA-Directed DNA Polymerase; Uracil; Virus Replication; Zidovudine

1996
Three-drug combination of MKC-442, lamivudine and zidovudine in vitro: potential approach towards effective chemotherapy against HIV-1.
    AIDS (London, England), 1997, Mar-15, Volume: 11, Issue:4

    Topics: Anti-HIV Agents; Cell Line, Transformed; Cells, Cultured; Drug Synergism; HIV Reverse Transcriptase; HIV-1; Humans; Lamivudine; Leukocytes, Mononuclear; Uracil; Zidovudine

1997
Synthesis and evaluation of "AZT-HEPT", "AZT-pyridinone", and "ddC-HEPT" conjugates as inhibitors of HIV reverse transcriptase.
    Journal of medicinal chemistry, 2000, May-18, Volume: 43, Issue:10

    Topics: Anti-HIV Agents; Cytidine; Enzyme Inhibitors; HIV Reverse Transcriptase; HIV-1; HIV-2; Molecular Structure; Pyridones; Structure-Activity Relationship; Uracil; Zalcitabine; Zidovudine

2000
Microwave-assisted synthesis of O'-adamantylated uracil-derived nucleosides.
    Nucleosides, nucleotides & nucleic acids, 2003, Volume: 22, Issue:1

    Topics: Adamantane; Deoxyuridine; Hot Temperature; HSP70 Heat-Shock Proteins; Microwaves; Molecular Chaperones; Nucleosides; Saccharomyces cerevisiae Proteins; Thymidine; Uracil; Zidovudine

2003
An efficient synthesis of 3-fluoro-5-thio-xylofuranosyl nucleosides of thymine, uracil, and 5-fluorouracil as potential antitumor or/and antiviral agents.
    Bioorganic & medicinal chemistry, 2007, May-01, Volume: 15, Issue:9

    Topics: Antineoplastic Agents; Antiviral Agents; Caco-2 Cells; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Fluorouracil; Humans; Intestines; Microbial Sensitivity Tests; Molecular Structure; Nucleosides; Rotavirus; Stereoisomerism; Structure-Activity Relationship; Thymine; Uracil; Xylose; Zidovudine

2007
Synthesis and antiviral activity of new dimeric inhibitors against HIV-1.
    Bioorganic & medicinal chemistry, 2008, Jan-01, Volume: 16, Issue:1

    Topics: Anti-HIV Agents; Dimerization; HIV-1; Humans; Mutation; Pyrimidines; Uracil; Zidovudine

2008
Origin of pyrimidine deoxyribonucleotide pools in perfused rat heart: implications for 3'-azido-3'-deoxythymidine-dependent cardiotoxicity.
    The Biochemical journal, 2009, Aug-27, Volume: 422, Issue:3

    Topics: Animals; Chromatography, High Pressure Liquid; Cytidine; Cytidine Triphosphate; Deoxyadenine Nucleotides; Deoxycytidine; Deoxycytosine Nucleotides; Deoxyguanine Nucleotides; Deoxyuridine; Heart; In Vitro Techniques; Male; Perfusion; Phosphorylation; Pyrimidine Nucleotides; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Inhibitors; Thymine Nucleotides; Uracil; Uridine; Uridine Monophosphate; Uridine Triphosphate; Zidovudine

2009
Fishing in the (deoxyribonucleotide) pool.
    The Biochemical journal, 2009, Aug-27, Volume: 422, Issue:3

    Topics: Animals; Antimetabolites; Cytidine; Cytidine Triphosphate; Deoxyadenine Nucleotides; Deoxycytidine; Deoxycytosine Nucleotides; Deoxyguanine Nucleotides; Deoxyuridine; Heart; Humans; Mitochondria; Mitochondrial Diseases; Models, Biological; Phosphorylation; Pyrimidine Nucleotides; Rats; Thymine Nucleotides; Uracil; Uridine; Uridine Monophosphate; Uridine Triphosphate; Zidovudine

2009
Epigallocatechin gallate inhibits the HIV reverse transcription step.
    Antiviral chemistry & chemotherapy, 2011, Jul-04, Volume: 21, Issue:6

    Topics: Anti-HIV Agents; Catechin; Drug Evaluation, Preclinical; Drug Synergism; HeLa Cells; HIV Infections; HIV Reverse Transcriptase; HIV-1; HIV-2; Humans; Reverse Transcriptase Inhibitors; Reverse Transcription; Uracil; Zidovudine

2011