Page last updated: 2024-08-23

zidovudine and etravirine

zidovudine has been researched along with etravirine in 58 studies

Research

Studies (58)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (1.72)29.6817
2010's46 (79.31)24.3611
2020's11 (18.97)2.80

Authors

AuthorsStudies
Barbault, F; Chen, CH; Huang, L; Huang, R; Jiang, S; Jiang, X; Lee, KH; Lu, H; Qian, K; Qin, B; Tian, X; Xie, L1
Corbau, R; Fishburn, L; Irving, S; Knöchel, T; Martin, A; Mori, J; Mowbray, C; Panton, W; Perros, M; Phillips, C; Ringrose, H; Smith-Burchnell, C; Thornberry, A; Westby, M; Wood, A1
Balzarini, J; Chen, FE; De Clercq, E; Gu, SX; He, QQ; Ma, XD; Pannecouque, C; Yang, SQ1
Chen, W; Chen, X; De Clercq, E; Li, D; Li, X; Liu, X; Pannecouque, C; Tian, Y; Zhan, P1
Balzarini, J; Chen, FE; Clercq, ED; Dai, HF; Gu, SX; He, QQ; Ma, XD; Pannecouque, C; Yang, SQ1
De Clercq, E; Li, D; Liu, X; Zhan, P1
Balzarini, J; Chen, X; De Clercq, E; Liu, X; Pannecouque, C; Zhan, P1
Balzarini, J; Chen, FE; De Clercq, E; Gu, SX; He, QQ; Li, ZM; Ma, XD; Pannecouque, C; Yang, SQ1
Chen, X; Cheng, Z; De Clercq, E; Liu, X; Meng, C; Pannecouque, C; Shao, S; Zhan, P1
Brancale, A; Clotet, B; Coluccia, A; Cosconati, S; Esté, JA; Famiglini, V; Gonzalez, E; La Regina, G; Maga, G; Novellino, E; Piscitelli, F; Samuele, A; Schols, D; Silvestri, R1
Briñón, MC; Daelemans, D; Dehaen, W; Leen, V; Madrid, M; Pannecouque, C; Ribone, SR1
Chen, FE; Daelemans, D; De Clercq, E; Liu, Y; Ma, XD; Pannecouque, C; Yang, S1
Balzarini, J; Chen, FE; Chen, WX; Daelemans, D; De Clercq, E; He, QQ; Pannecouque, C; Wu, HQ; Yan, ZH1
Balzarini, J; Chen, X; De Clercq, E; Li, Z; Liu, H; Liu, X; Pannecouque, C; Xie, Z; Zhan, P; Zhang, L; Zhao, T1
De Clercq, E; Li, Z; Liu, H; Liu, X; Pannecouque, C; Wang, J; Zhan, P1
Chen, FE; Chen, WX; De Clercq, E; He, QQ; Huang, XY; Pannecouque, C; Wu, HQ; Yan, ZH1
Badia, R; Brancale, A; Cirilli, R; Clotet, B; Coluccia, A; Crespan, E; Esté, JA; Famiglini, V; La Regina, G; Maga, G; Novellino, E; Pelliccia, S; Silvestri, R1
Chen, FE; Chen, WX; De Clercq, E; He, QQ; Pannecouque, C; Piao, HR; Wu, HQ; Wu, Y; Yan, ZH1
Collu, G; Giliberti, G; La Colla, P; Loddo, R; Loksha, YM; Pedersen, EB; Sanna, G1
Chen, W; De Clercq, E; Liu, X; Liu, Z; Pannecouque, C; Zhan, P1
Chen, FE; Chen, WX; Daelemans, D; De Clercq, E; He, QQ; Pannecouque, C; Wu, HQ; Yao, J1
Balzarini, J; Chen, W; De Clercq, E; Fu, L; Huang, B; Li, C; Liu, H; Liu, T; Liu, X; Pannecouque, C; Sun, Y; Yu, M; Zhan, P1
Chen, W; De Clercq, E; Fu, L; Huang, B; Li, C; Li, X; Liang, X; Liu, H; Liu, T; Liu, X; Pannecouque, C; Sun, Y; Zhan, P1
Chen, FE; Chen, WX; Daelemans, D; De Clercq, E; He, QQ; Mao, TQ; Pannecouque, C; Tang, GF; Wan, ZY1
Chen, W; Daelemans, D; De Clercq, E; Huang, B; Kang, D; Li, X; Liu, X; Liu, Z; Lu, X; Pannecouque, C; Yang, J; Zhan, P1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Chen, X; Daelemans, D; De Clercq, E; Huang, B; Kang, D; Li, W; Liu, X; Meng, Q; Pannecouque, C; Zhan, P1
Chizhov, AO; Geisman, AN; Khandazhinskaya, AL; Kochetkov, SN; Naesens, L; Novikov, MS; Ozerov, AA; Pannecouque, C; Seley-Radtke, KL; Valuev-Elliston, VT1
Buckheit, RW; Cushman, M; Hartman, TL; Hoshi, A; Okazaki, M; Pannecouque, C; Sakamoto, T; Takayama, J; Xuan, M1
Chen, W; Daelemans, D; De Clercq, E; Huang, B; Liu, X; Pannecouque, C; Yang, J; Zhan, P1
Daelemans, D; De Clercq, E; Ding, X; Fang, Z; Huang, B; Kang, D; Li, Z; Liu, X; Lu, X; Pannecouque, C; Xu, H; Zhan, P; Zhang, H; Zhou, Z1
De Clercq, E; Huo, Z; Kang, D; Liu, H; Liu, X; Pannecouque, C; Tian, Y; Zhan, P; Zhang, H; Zhou, Z1
Gu, SX; Ju, XL; Li, TT; Lu, HH; Pannecouque, C; Xiao, T; Xue, P; Zhang, X; Zheng, XJ; Zhu, YY1
Gu, SX; Ju, XL; Liu, GY; Lu, HH; Pannecouque, C; Xue, P; Zhang, XL; Zheng, XJ; Zhu, YY1
Daelemans, D; De Clercq, E; Ding, X; Fang, Z; Huang, B; Huo, Z; Kang, D; Liu, X; Lu, X; Meng, Q; Pannecouque, C; Tian, Y; Wu, G; Xu, H; Yu, Z; Zhan, P; Zhang, H; Zhou, Z1
Badia, R; Brambilla, A; Brancale, A; Catalano, M; Cirilli, R; Coluccia, A; Crespan, E; Esté, JA; Famiglini, V; Formica, FR; La Regina, G; Limatola, C; Maga, G; Masci, D; Novellino, E; Riveira-Muñoz, E; Silvestri, R1
Daelemans, D; De Clercq, E; Huang, B; Kang, D; Liu, J; Liu, X; Liu, Z; Pannecouque, C; Tian, Y; Zhan, P1
Daelemans, D; De Clercq, E; Ding, X; Feng, D; Huo, Z; Kang, D; Liu, X; Pannecouque, C; Tian, Y; Wang, Z; Wu, G; Zhan, P; Zhao, T; Zhou, Z1
Chen, F; De Clercq, E; Jin, K; Meng, G; Pannecouque, C; Yin, H1
Daelemans, D; De Clercq, E; Gao, P; Kang, D; Liu, X; Lu, X; Pannecouque, C; Yang, J; Zhan, P1
Chen, CH; Daelemans, D; De Clercq, E; Huang, B; Kang, D; Lee, KH; Liu, J; Liu, X; Liu, Z; Pannecouque, C; Tian, Y; Zhan, P; Zhang, H1
Daelemans, D; De Clercq, E; Desta, S; Ding, X; Huo, Z; Jing, L; Kang, D; Liu, X; Pannecouque, C; Wang, Z; Wu, G; Zhan, P; Zhang, H; Zhou, Z; Zuo, X1
Clercq, E; Daelemans, D; Ding, X; Feng, D; Guma, S; Huang, B; Huo, Z; Jing, L; Kang, D; Liu, X; Luo, W; Pannecouque, C; Wang, Z; Wu, G; Zhan, P; Zhang, H; Zhang, J; Zhao, T; Zhou, Z; Zuo, X1
Byrareddy, SN; Kongsted, J; Kramer, VG; Kurup, S; Liu, X; Namasivayam, V; Vanangamudi, M; Zhan, P1
Chen, FE; Gu, SX; Liu, GY; Meng, G; Pannecouque, C; Tang, JF; Wu, FS; Xiao, T; Xu, ZQ; Zhu, YY1
Armijos Rivera, JI; Badia, R; Brambilla, A; Catalano, M; Cinquina, E; Coluccia, A; Crespan, E; Esté, JA; Falasca, F; La Regina, G; Limatola, C; Maga, G; Masci, D; Nalli, M; Riveira-Muñoz, E; Silvestri, R; Turriziani, O1
Cherukupalli, S; De Clercq, E; Feng, D; Fu, Z; Jiang, X; Kang, D; Liu, X; Pannecouque, C; Wang, Z; Zhan, P1
De Clercq, E; Huang, B; Jiang, X; Kang, D; Li, J; Liu, X; Olotu, FA; Pannecouque, C; Soliman, MES; Wang, Z; Zhan, P1
Chen, CH; De Clercq, E; Feng, D; Jing, L; Kang, D; Lee, KH; Lin, H; Liu, X; Olotu, FA; Pannecouque, C; Soliman, M; Zhan, P; Zuo, X1
De Clercq, E; Gao, P; Liu, X; Pannecouque, C; Song, S; Sun, L; Wang, Z; Zhan, P; Zhang, J1
Cherukupalli, S; De Clercq, E; Fu, Z; Gao, S; Kang, D; Liu, X; Pannecouque, C; Sun, L; Zhan, P; Zhang, T; Zhou, Z1
Chen, FE; De Clercq, E; Jin, X; Pannecouque, C; Piao, HR; Zhuang, C1
Cheng, Y; De Clercq, E; Gao, P; Gao, S; Kang, D; Liu, X; Pannecouque, C; Song, L; Song, S; Sun, L; Xu, S; Zhan, P; Zhao, F1
Chen, FE; Clercq, E; Hao, QQ; Ling, X; Pannecouque, C1
Dranchak, PK; Huang, R; Inglese, J; Lamy, L; Oliphant, E; Queme, B; Tao, D; Wang, Y; Xia, M1
Danner, SA; Gruzdev, B; Jurriaans, S; Lange, JM; Peeters, M; Prins, JM; Rakhmanova, A; Sankatsing, SU; van't Klooster, G; Weverling, GJ1
Claassen, M; Preiser, W; van der Merwe, L; van Zyl, GU; Zeier, M1
Delviks-Frankenberry, KA; Kearney, MF; Lengruber, RB; Maldarelli, F; Pathak, VK; Santos, AF; Silveira, JM; Soares, MA1

Reviews

1 review(s) available for zidovudine and etravirine

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Trials

1 trial(s) available for zidovudine and etravirine

ArticleYear
TMC125 exerts similar initial antiviral potency as a five-drug, triple class antiretroviral regimen.
    AIDS (London, England), 2003, Dec-05, Volume: 17, Issue:18

    Topics: Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Dideoxynucleosides; Double-Blind Method; Drug Therapy, Combination; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Indinavir; Lamivudine; Male; Nevirapine; Nitriles; Pyridazines; Pyrimidines; Reverse Transcriptase Inhibitors; RNA, Viral; Treatment Outcome; Zidovudine

2003

Other Studies

56 other study(ies) available for zidovudine and etravirine

ArticleYear
Diarylaniline derivatives as a distinct class of HIV-1 non-nucleoside reverse transcriptase inhibitors.
    Journal of medicinal chemistry, 2010, Jul-08, Volume: 53, Issue:13

    Topics: Aniline Compounds; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Hydrogen Bonding; Magnetic Resonance Spectroscopy; Models, Molecular; Reverse Transcriptase Inhibitors; Spectrometry, Mass, Electrospray Ionization; Structure-Activity Relationship

2010
Lersivirine, a nonnucleoside reverse transcriptase inhibitor with activity against drug-resistant human immunodeficiency virus type 1.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:10

    Topics: Cell Line; Cell Line, Tumor; Crystallography, X-Ray; Drug Resistance, Viral; HIV Reverse Transcriptase; HIV-1; Humans; Molecular Sequence Data; Mutagenesis, Site-Directed; Nitriles; Pyrazoles; Reverse Transcriptase Inhibitors

2010
Synthesis and structure-activity relationship of novel diarylpyrimidines with hydromethyl linker (CH(OH)-DAPYs) as HIV-1 NNRTIs.
    Bioorganic & medicinal chemistry, 2011, Sep-01, Volume: 19, Issue:17

    Topics: Aniline Compounds; Cell Line; Chlorine; HIV Reverse Transcriptase; HIV-1; Humans; Mutation; Pyrimidines; Reverse Transcriptase Inhibitors; Structure-Activity Relationship

2011
Arylazolylthioacetanilide. Part 8: Design, synthesis and biological evaluation of novel 2-(2-(2,4-dichlorophenyl)-2H-1,2,4-triazol-3-ylthio)-N-arylacetamides as potent HIV-1 inhibitors.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:10

    Topics: Acetamides; Anti-HIV Agents; Cell Line; HIV Infections; HIV Reverse Transcriptase; HIV-1; HIV-2; Humans; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Triazoles; Virus Replication

2011
Design, synthesis and biological evaluation of cycloalkyl arylpyrimidines (CAPYs) as HIV-1 NNRTIs.
    Bioorganic & medicinal chemistry, 2011, Dec-01, Volume: 19, Issue:23

    Topics: Anti-HIV Agents; HIV Reverse Transcriptase; HIV-1; Humans; Models, Molecular; Pyrimidines; Reverse Transcriptase Inhibitors; Structure-Activity Relationship

2011
Strategies for the design of HIV-1 non-nucleoside reverse transcriptase inhibitors: lessons from the development of seven representative paradigms.
    Journal of medicinal chemistry, 2012, Apr-26, Volume: 55, Issue:8

    Topics: Anti-HIV Agents; Benzodiazepines; Binding Sites; Crystallography, X-Ray; Drug Design; HIV Reverse Transcriptase; HIV-1; Hydrogen Bonding; Imidazoles; Indoles; Nitriles; Reverse Transcriptase Inhibitors; Structure-Activity Relationship

2012
Synthesis and biological evaluation of piperidine-substituted triazine derivatives as HIV-1 non-nucleoside reverse transcriptase inhibitors.
    European journal of medicinal chemistry, 2012, Volume: 51

    Topics: Anti-HIV Agents; Cell Line; Chemistry Techniques, Synthetic; HIV Reverse Transcriptase; HIV-1; Inhibitory Concentration 50; Piperidines; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Triazines

2012
Chiral resolution, absolute configuration assignment and biological activity of racemic diarylpyrimidine CH(OH)-DAPY as potent nonnucleoside HIV-1 reverse transcriptase inhibitors.
    European journal of medicinal chemistry, 2012, Volume: 53

    Topics: HIV Reverse Transcriptase; HIV-1; HIV-2; Models, Molecular; Protein Conformation; Pyrimidines; Reverse Transcriptase Inhibitors; Stereoisomerism

2012
Design, synthesis, anti-HIV evaluation and molecular modeling of piperidine-linked amino-triazine derivatives as potent non-nucleoside reverse transcriptase inhibitors.
    Bioorganic & medicinal chemistry, 2012, Jun-15, Volume: 20, Issue:12

    Topics: Amines; Anti-HIV Agents; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Design; HIV Reverse Transcriptase; HIV-1; HIV-2; Humans; Microbial Sensitivity Tests; Models, Molecular; Molecular Structure; Piperidines; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Triazines

2012
New nitrogen containing substituents at the indole-2-carboxamide yield high potent and broad spectrum indolylarylsulfone HIV-1 non-nucleoside reverse transcriptase inhibitors.
    Journal of medicinal chemistry, 2012, Jul-26, Volume: 55, Issue:14

    Topics: Cell Line; HIV Reverse Transcriptase; HIV-1; Indoles; Mutation; Nitrogen; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Sulfones

2012
Synthesis, biological evaluation and molecular modeling of 4,6-diarylpyrimidines and diarylbenzenes as novel non-nucleosides HIV-1 reverse transcriptase inhibitors.
    European journal of medicinal chemistry, 2012, Volume: 58

    Topics: Anti-HIV Agents; Antineoplastic Agents; Benzene Derivatives; Cell Survival; Crystallography, X-Ray; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; HIV Reverse Transcriptase; HIV-1; HIV-2; Humans; Models, Molecular; Molecular Structure; Pyrimidines; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Tumor Cells, Cultured

2012
Molecular design, synthesis and biological evaluation of BP-O-DAPY and O-DAPY derivatives as non-nucleoside HIV-1 reverse transcriptase inhibitors.
    European journal of medicinal chemistry, 2013, Volume: 65

    Topics: Anti-HIV Agents; Benzophenones; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Design; HIV Reverse Transcriptase; HIV-1; HIV-2; Humans; Microbial Sensitivity Tests; Models, Molecular; Molecular Structure; Pyrimidines; Reverse Transcriptase Inhibitors; Structure-Activity Relationship

2013
Towards new C6-rigid S-DABO HIV-1 reverse transcriptase inhibitors: synthesis, biological investigation and molecular modeling studies.
    Bioorganic & medicinal chemistry, 2013, Nov-01, Volume: 21, Issue:21

    Topics: Binding Sites; HIV Reverse Transcriptase; HIV-1; Humans; Molecular Docking Simulation; Protein Binding; Protein Structure, Tertiary; Pyrimidines; Pyrimidinones; Reverse Transcriptase Inhibitors; Structure-Activity Relationship

2013
Design, synthesis and preliminary SAR studies of novel N-arylmethyl substituted piperidine-linked aniline derivatives as potent HIV-1 NNRTIs.
    Bioorganic & medicinal chemistry, 2014, Jan-01, Volume: 22, Issue:1

    Topics: Aniline Compounds; Anti-HIV Agents; Drug Design; HIV-1; Humans; Models, Molecular; Piperidines; Structure-Activity Relationship

2014
Discovery of nitropyridine derivatives as potent HIV-1 non-nucleoside reverse transcriptase inhibitors via a structure-based core refining approach.
    European journal of medicinal chemistry, 2014, Apr-09, Volume: 76

    Topics: Cell Line; Drug Discovery; HIV Reverse Transcriptase; HIV-1; Humans; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Molecular Docking Simulation; Molecular Structure; Pyridines; Reverse Transcriptase Inhibitors; Spectrometry, Mass, Electrospray Ionization; Structure-Activity Relationship; Virus Replication

2014
Structural modifications of CH(OH)-DAPYs as new HIV-1 non-nucleoside reverse transcriptase inhibitors.
    Bioorganic & medicinal chemistry, 2014, Apr-15, Volume: 22, Issue:8

    Topics: Binding Sites; Cell Line; HIV Reverse Transcriptase; HIV-1; Humans; Molecular Docking Simulation; Protein Structure, Tertiary; Pyrimidines; Reverse Transcriptase Inhibitors; Structure-Activity Relationship

2014
New indolylarylsulfones as highly potent and broad spectrum HIV-1 non-nucleoside reverse transcriptase inhibitors.
    European journal of medicinal chemistry, 2014, Jun-10, Volume: 80

    Topics: Cell Line; Drug Design; HIV Reverse Transcriptase; HIV-1; Humans; Indoles; Inhibitory Concentration 50; Models, Molecular; Protein Conformation; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Sulfones

2014
Synthesis and biological evaluation of CHX-DAPYs as HIV-1 non-nucleoside reverse transcriptase inhibitors.
    Bioorganic & medicinal chemistry, 2014, Jun-15, Volume: 22, Issue:12

    Topics: Anti-HIV Agents; Benzamides; Cell Survival; Cells, Cultured; Drug Design; HIV Reverse Transcriptase; HIV-1; Humans; Models, Molecular; Molecular Docking Simulation; Molecular Structure; Nitriles; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pyrimidines; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Tumor Cells, Cultured; Virus Replication

2014
Synthesis of novel fluoro analogues of MKC442 as microbicides.
    Journal of medicinal chemistry, 2014, Jun-26, Volume: 57, Issue:12

    Topics: Anti-HIV Agents; Cell Line; Drug Resistance, Viral; HIV Protease Inhibitors; HIV Reverse Transcriptase; HIV-1; Humans; Mutation; Pyrimidinones; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Uracil

2014
Design, synthesis and anti-HIV evaluation of novel diarylnicotinamide derivatives (DANAs) targeting the entrance channel of the NNRTI binding pocket through structure-guided molecular hybridization.
    European journal of medicinal chemistry, 2014, Nov-24, Volume: 87

    Topics: Anti-HIV Agents; Catalytic Domain; Dose-Response Relationship, Drug; Drug Design; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Models, Molecular; Molecular Structure; Niacinamide; Protein Conformation; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Tumor Cells, Cultured

2014
Synthesis and biological evaluation of DAPY-DPEs hybrids as non-nucleoside inhibitors of HIV-1 reverse transcriptase.
    Bioorganic & medicinal chemistry, 2015, Feb-01, Volume: 23, Issue:3

    Topics: Anti-HIV Agents; Binding Sites; Cell Line; Drug Design; HIV Reverse Transcriptase; HIV-1; Humans; Pyrimidines; Reverse Transcriptase Inhibitors; Structure-Activity Relationship

2015
Fused heterocycles bearing bridgehead nitrogen as potent HIV-1 NNRTIs. Part 3: optimization of [1,2,4]triazolo[1,5-a]pyrimidine core via structure-based and physicochemical property-driven approaches.
    European journal of medicinal chemistry, 2015, Mar-06, Volume: 92

    Topics: Anti-HIV Agents; Cell Line, Tumor; Dose-Response Relationship, Drug; Heterocyclic Compounds; Heterocyclic Compounds, 2-Ring; HIV Reverse Transcriptase; HIV-1; Humans; Microbial Sensitivity Tests; Models, Molecular; Molecular Structure; Nitrogen; Reverse Transcriptase Inhibitors; Solubility; Structure-Activity Relationship; Sulfones

2015
Fused heterocycles bearing bridgehead nitrogen as potent HIV-1 NNRTIs. Part 4: design, synthesis and biological evaluation of novel imidazo[1,2-a]pyrazines.
    European journal of medicinal chemistry, 2015, Mar-26, Volume: 93

    Topics: Anti-HIV Agents; Chemistry Techniques, Synthetic; Computational Biology; Drug Design; HIV Reverse Transcriptase; HIV-1; Imidazoles; Molecular Docking Simulation; Protein Conformation; Pyrazines; Reverse Transcriptase Inhibitors; Structure-Activity Relationship

2015
Anti-HIV diarylpyrimidine-quinolone hybrids and their mode of action.
    Bioorganic & medicinal chemistry, 2015, Jul-01, Volume: 23, Issue:13

    Topics: Anti-HIV Agents; Binding Sites; Cell Line; Drug Design; Granulocyte Precursor Cells; HIV Reverse Transcriptase; HIV-1; Humans; Models, Molecular; Molecular Docking Simulation; Pyrimidines; Quinolones; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Virus Latency

2015
Design, synthesis and anti-HIV evaluation of novel diarylpyridine derivatives targeting the entrance channel of NNRTI binding pocket.
    European journal of medicinal chemistry, 2016, Feb-15, Volume: 109

    Topics: Anti-HIV Agents; Binding Sites; Drug Design; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Molecular Docking Simulation; Point Mutation; Pyridines; Reverse Transcriptase Inhibitors; Structure-Activity Relationship

2016
Design, synthesis and evaluation of novel HIV-1 NNRTIs with dual structural conformations targeting the entrance channel of the NNRTI binding pocket.
    European journal of medicinal chemistry, 2016, Jun-10, Volume: 115

    Topics: Anti-HIV Agents; Binding Sites; Dose-Response Relationship, Drug; Drug Design; HIV Reverse Transcriptase; HIV-1; Humans; Microbial Sensitivity Tests; Molecular Structure; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Virus Replication

2016
1,6-Bis[(benzyloxy)methyl]uracil derivatives-Novel antivirals with activity against HIV-1 and influenza H1N1 virus.
    Bioorganic & medicinal chemistry, 2016, 06-01, Volume: 24, Issue:11

    Topics: Animals; Antiviral Agents; Cells, Cultured; Dogs; Dose-Response Relationship, Drug; HIV-1; Influenza A Virus, H1N1 Subtype; Madin Darby Canine Kidney Cells; Microbial Sensitivity Tests; Models, Molecular; Molecular Structure; Structure-Activity Relationship; Uracil

2016
Systematic evaluation of methyl ester bioisosteres in the context of developing alkenyldiarylmethanes (ADAMs) as non-nucleoside reverse transcriptase inhibitors (NNRTIs) for anti-HIV-1 chemotherapy.
    Bioorganic & medicinal chemistry, 2016, 07-01, Volume: 24, Issue:13

    Topics: Anti-HIV Agents; Drug Stability; Esters; HIV-1; Humans; Inhibitory Concentration 50; Methane; Models, Molecular; Reverse Transcriptase Inhibitors

2016
Structural optimization of pyridine-type DAPY derivatives to exploit the tolerant regions of the NNRTI binding pocket.
    European journal of medicinal chemistry, 2016, Oct-04, Volume: 121

    Topics: Binding Sites; Dose-Response Relationship, Drug; Drug Design; HIV Reverse Transcriptase; Molecular Docking Simulation; Protein Conformation; Pyridines; Pyrimidines; Reverse Transcriptase Inhibitors; Solubility; Structure-Activity Relationship; Water

2016
Design, Synthesis, and Evaluation of Thiophene[3,2-d]pyrimidine Derivatives as HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors with Significantly Improved Drug Resistance Profiles.
    Journal of medicinal chemistry, 2016, 09-08, Volume: 59, Issue:17

    Topics: Animals; Anti-HIV Agents; Cell Line, Tumor; Drug Resistance, Viral; Heterocyclic Compounds, 2-Ring; HIV Reverse Transcriptase; HIV-1; Humans; Male; Mice; Molecular Docking Simulation; Mutation; Pyrimidines; Rats, Sprague-Dawley; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Sulfonamides; Thiophenes

2016
Discovery of uracil-bearing DAPYs derivatives as novel HIV-1 NNRTIs via crystallographic overlay-based molecular hybridization.
    European journal of medicinal chemistry, 2017, Apr-21, Volume: 130

    Topics: Animals; Anti-HIV Agents; Cell Line; Drug Discovery; HIV Reverse Transcriptase; HIV-1; Mice; Models, Molecular; Reverse Transcriptase Inhibitors; Solubility; Structure-Activity Relationship; Uracil

2017
Structural modifications of diarylpyrimidines (DAPYs) as HIV-1 NNRTIs: Synthesis, anti-HIV activities and SAR.
    Bioorganic & medicinal chemistry, 2017, 04-15, Volume: 25, Issue:8

    Topics: Anti-HIV Agents; Carbon-13 Magnetic Resonance Spectroscopy; HIV-1; Molecular Docking Simulation; Proton Magnetic Resonance Spectroscopy; Pyrimidines; Reverse Transcriptase Inhibitors; Spectrometry, Mass, Electrospray Ionization

2017
Design and synthesis of hybrids of diarylpyrimidines and diketo acids as HIV-1 inhibitors.
    Bioorganic & medicinal chemistry letters, 2017, 04-15, Volume: 27, Issue:8

    Topics: Anti-HIV Agents; Cell Line; Drug Design; HIV Infections; HIV Integrase; HIV Integrase Inhibitors; HIV-1; Humans; Keto Acids; Molecular Docking Simulation; Pyrimidines; Reverse Transcriptase Inhibitors

2017
Structure-Based Optimization of Thiophene[3,2-d]pyrimidine Derivatives as Potent HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors with Improved Potency against Resistance-Associated Variants.
    Journal of medicinal chemistry, 2017, 05-25, Volume: 60, Issue:10

    Topics: Animals; Anti-HIV Agents; Drug Resistance, Viral; HEK293 Cells; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Models, Molecular; Pyrimidines; Rats, Sprague-Dawley; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Thiophenes

2017
Chiral Indolylarylsulfone Non-Nucleoside Reverse Transcriptase Inhibitors as New Potent and Broad Spectrum Anti-HIV-1 Agents.
    Journal of medicinal chemistry, 2017, 08-10, Volume: 60, Issue:15

    Topics: Animals; Anti-HIV Agents; Cells, Cultured; Glutamic Acid; HIV-1; Humans; Indoles; Lipopolysaccharides; Mice, Inbred C57BL; Microglia; Molecular Docking Simulation; Mutation; Neurons; Neuroprotective Agents; Reverse Transcriptase Inhibitors; Stereoisomerism; Structure-Activity Relationship; Sulfones

2017
Design, synthesis and anti-HIV evaluation of novel diarylpyridine derivatives as potent HIV-1 NNRTIs.
    European journal of medicinal chemistry, 2017, Nov-10, Volume: 140

    Topics: Anti-HIV Agents; Carbon-13 Magnetic Resonance Spectroscopy; Cell Line; Drug Design; HIV-1; Humans; Microbial Sensitivity Tests; Molecular Docking Simulation; Proton Magnetic Resonance Spectroscopy; Reverse Transcriptase Inhibitors; Spectrometry, Mass, Electrospray Ionization

2017
Discovery of Thiophene[3,2-
    ACS medicinal chemistry letters, 2017, Nov-09, Volume: 8, Issue:11

    Topics:

2017
Discovery of biphenyl-substituted diarylpyrimidines as non-nucleoside reverse transcriptase inhibitors with high potency against wild-type and mutant HIV-1.
    European journal of medicinal chemistry, 2018, Feb-10, Volume: 145

    Topics: Anti-HIV Agents; Biphenyl Compounds; Cell Survival; Dose-Response Relationship, Drug; Drug Discovery; HIV Reverse Transcriptase; HIV-1; Humans; Microbial Sensitivity Tests; Molecular Docking Simulation; Molecular Structure; Mutation; Pyrimidines; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Tumor Cells, Cultured

2018
The discovery of novel diarylpyri(mi)dine derivatives with high level activity against a wide variety of HIV-1 strains as well as against HIV-2.
    Bioorganic & medicinal chemistry, 2018, 05-01, Volume: 26, Issue:8

    Topics: Allosteric Regulation; Binding Sites; Drug Design; HIV Reverse Transcriptase; HIV-1; HIV-2; Humans; Molecular Docking Simulation; Protein Structure, Tertiary; Pyrimidines; Reverse Transcriptase Inhibitors; Structure-Activity Relationship

2018
Targeting the entrance channel of NNIBP: Discovery of diarylnicotinamide 1,4-disubstituted 1,2,3-triazoles as novel HIV-1 NNRTIs with high potency against wild-type and E138K mutant virus.
    European journal of medicinal chemistry, 2018, May-10, Volume: 151

    Topics: Anti-HIV Agents; Drug Design; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Molecular Docking Simulation; Niacinamide; Point Mutation; Structure-Activity Relationship; Triazoles

2018
Discovery of Novel Diarylpyrimidine Derivatives as Potent HIV-1 NNRTIs Targeting the "NNRTI Adjacent" Binding Site.
    ACS medicinal chemistry letters, 2018, Apr-12, Volume: 9, Issue:4

    Topics:

2018
Further Exploring Solvent-Exposed Tolerant Regions of Allosteric Binding Pocket for Novel HIV-1 NNRTIs Discovery.
    ACS medicinal chemistry letters, 2018, Apr-12, Volume: 9, Issue:4

    Topics:

2018
The Journey of HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs) from Lab to Clinic.
    Journal of medicinal chemistry, 2019, 05-23, Volume: 62, Issue:10

    Topics: Animals; Anti-HIV Agents; Clinical Trials as Topic; Drug Discovery; HIV Infections; HIV-1; Humans; Reverse Transcriptase Inhibitors

2019
Indazolyl-substituted piperidin-4-yl-aminopyrimidines as HIV-1 NNRTIs: Design, synthesis and biological activities.
    European journal of medicinal chemistry, 2020, Jan-15, Volume: 186

    Topics: Anti-HIV Agents; Dose-Response Relationship, Drug; Drug Design; HIV; HIV Reverse Transcriptase; Humans; Indazoles; Microbial Sensitivity Tests; Molecular Structure; Piperidines; Pyrimidines; Reverse Transcriptase Inhibitors; Structure-Activity Relationship

2020
New indolylarylsulfone non-nucleoside reverse transcriptase inhibitors show low nanomolar inhibition of single and double HIV-1 mutant strains.
    European journal of medicinal chemistry, 2020, Dec-15, Volume: 208

    Topics: Anti-HIV Agents; Cell Line, Tumor; Drug Design; Drug Synergism; HIV Reverse Transcriptase; HIV-1; Humans; Indoles; Microbial Sensitivity Tests; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Structure; Mutation; Protein Binding; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Sulfones; Zidovudine

2020
Targeting dual tolerant regions of binding pocket: Discovery of novel morpholine-substituted diarylpyrimidines as potent HIV-1 NNRTIs with significantly improved water solubility.
    European journal of medicinal chemistry, 2020, Nov-15, Volume: 206

    Topics: Binding Sites; HIV Reverse Transcriptase; HIV-1; Morpholines; Mutation; Pyrimidines; Reverse Transcriptase Inhibitors; Solubility; Structure-Activity Relationship; Water

2020
Exploiting the tolerant region I of the non-nucleoside reverse transcriptase inhibitor (NNRTI) binding pocket. Part 2: Discovery of diarylpyrimidine derivatives as potent HIV-1 NNRTIs with high Fsp
    European journal of medicinal chemistry, 2021, Mar-05, Volume: 213

    Topics: Anti-HIV Agents; Binding Sites; Drug Design; HIV-1; Humans; Molecular Docking Simulation; Molecular Dynamics Simulation; Protein Binding; Pyrimidines; Reverse Transcriptase Inhibitors; Structure-Activity Relationship

2021
Design, synthesis, and evaluation of "dual-site"-binding diarylpyrimidines targeting both NNIBP and the NNRTI adjacent site of the HIV-1 reverse transcriptase.
    European journal of medicinal chemistry, 2021, Feb-05, Volume: 211

    Topics: Anti-HIV Agents; Drug Design; HIV Reverse Transcriptase; Humans; Molecular Dynamics Simulation; Molecular Structure; Pyrimidines; Structure-Activity Relationship

2021
Design, synthesis and anti-HIV evaluation of novel 5-substituted diarylpyrimidine derivatives as potent HIV-1 NNRTIs.
    Bioorganic & medicinal chemistry, 2021, 06-15, Volume: 40

    Topics: Anti-HIV Agents; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Design; HIV; HIV Reverse Transcriptase; Humans; Microbial Sensitivity Tests; Models, Molecular; Molecular Structure; Pyrimidines; Reverse Transcriptase Inhibitors; Structure-Activity Relationship

2021
Exploiting the hydrophobic channel of the NNIBP: Discovery of novel diarylpyrimidines as HIV-1 NNRTIs against wild-type and K103N mutant viruses.
    Bioorganic & medicinal chemistry, 2021, 07-15, Volume: 42

    Topics: Anti-HIV Agents; Dose-Response Relationship, Drug; Drug Discovery; HIV Reverse Transcriptase; HIV-1; Humans; Hydrophobic and Hydrophilic Interactions; Microbial Sensitivity Tests; Molecular Structure; Mutation; Reverse Transcriptase Inhibitors; Structure-Activity Relationship

2021
Design of the naphthyl-diarylpyrimidines as potent non-nucleoside reverse transcriptase inhibitors (NNRTIs) via structure-based extension into the entrance channel.
    European journal of medicinal chemistry, 2021, Dec-15, Volume: 226

    Topics: Anti-HIV Agents; Dose-Response Relationship, Drug; Drug Design; HIV Reverse Transcriptase; HIV-1; Humans; Microbial Sensitivity Tests; Molecular Structure; Naphthalenes; Pyrimidines; Reverse Transcriptase Inhibitors; Structure-Activity Relationship

2021
Chemical space exploration around indolylarylsulfone scaffold led to a novel class of highly active HIV-1 NNRTIs with spiro structural features.
    European journal of medicinal chemistry, 2022, Aug-05, Volume: 238

    Topics: Anti-HIV Agents; Drug Design; HIV Reverse Transcriptase; HIV-1; Molecular Structure; Reverse Transcriptase Inhibitors; Space Flight; Structure-Activity Relationship

2022
Expansion of the S-CN-DABO scaffold to exploit the impact on inhibitory activities against the non-nucleoside HIV-1 reverse transcriptase.
    European journal of medicinal chemistry, 2022, Aug-05, Volume: 238

    Topics: Animals; Anti-HIV Agents; HIV Reverse Transcriptase; HIV-1; Mice; Molecular Docking Simulation; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Inhibitors; Structure-Activity Relationship

2022
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
    Disease models & mechanisms, 2023, 03-01, Volume: 16, Issue:3

    Topics: Animals; Caenorhabditis elegans; Drug Discovery; High-Throughput Screening Assays; Humans; Proteomics; Small Molecule Libraries

2023
Antiretroviral resistance patterns and factors associated with resistance in adult patients failing NNRTI-based regimens in the Western Cape, South Africa.
    Journal of medical virology, 2011, Volume: 83, Issue:10

    Topics: Adult; Alkynes; Anti-HIV Agents; Benzoxazines; CD4 Lymphocyte Count; Cross-Sectional Studies; Cyclopropanes; Drug Resistance, Viral; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Male; Nevirapine; Nitriles; Pyridazines; Pyrimidines; Reverse Transcriptase Inhibitors; RNA, Viral; South Africa; Treatment Failure; Viral Load; Zidovudine

2011
Connection subdomain mutations in HIV-1 subtype-C treatment-experienced patients enhance NRTI and NNRTI drug resistance.
    Virology, 2013, Jan-20, Volume: 435, Issue:2

    Topics: Amino Acid Sequence; Anti-HIV Agents; Brazil; Cell Line; Drug Resistance, Viral; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Molecular Sequence Data; Mutation; Nitriles; Protein Structure, Tertiary; Pyridazines; Pyrimidines; Reverse Transcriptase Inhibitors; Zidovudine

2013
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