Page last updated: 2024-08-24

zanamivir and gs 4071

zanamivir has been researched along with gs 4071 in 33 studies

Research

Studies (33)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	1 (3.03)	18.2507
2000's	7 (21.21)	29.6817
2010's	20 (60.61)	24.3611
2020's	5 (15.15)	2.80

Authors

Authors	Studies
Bethell, RC; Evans, DN; Howes, PD; Robinson, JE; Smith, PW; Sollis, SL; Trivedi, N	1
Ananth, SL; Babu, YS; Bantia, S; Chand, P; Dehghani, A; El-Kattan, Y; Elliott, AJ; Horn, LL; Hutchison, TL; Kotian, P; Laver, GW; Lin, TH; Montgomery, JA; Parker, CD	1
Colman, PM; Fernley, RT; McDonald, M; McKimm-Breshkin, JL; Smith, BJ; Varghese, JN	1
Kollman, PA; Kuntz, ID; Masukawa, KM	1
Chen, XG; Chen, YL; Hu, ZD; Liu, MC; Lü, WJ; Luan, F; Ma, WP; Zhang, XY	1
Lombardo, F; Obach, RS; Waters, NJ	1
Chou, KC; González-Díaz, H; Martinez de la Vega, O; Prado-Prado, FJ; Ubeira, FM; Uriarte, E	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Cheng, YS; Fang, JM; Lee, PS; Liu, KC; Wang, SY; Wong, CH	1
Chen, CA; Chen, CL; Cheng, TJ; Cheng, YS; Fang, JM; Hsieh, WC; Hu, OY; Huang, PW; Jan, JT; Lin, WH; Shie, JJ; Tarbet, EB; Wang, SY; Weinheimer, S; Wong, CH	1
Andrew, PW; Borgianni, L; Docquier, JD; Hayre, JK; Oggioni, MR; Taylor, GL; Xu, G	1
Clement, B; Koch, O; Kotthaus, J; Müller-Fielitz, H; Raasch, W; Riebling, L; Schade, D; Schmidtke, M; Seidel, N	1
Cheng, TJ; Cheng, YS; Fang, JM; Huang, WI; Tsai, KC; Tseng, YC; Wang, PC; Wang, SY; Wong, CH	1
Bi, Y; Fu, L; Gao, GF; Li, X; Li, Y; Lu, X; Lv, X; Qi, J; Wu, Y; Yan, J; Zhang, S; Zhang, Z	1
Cheng, TJ; Cheng, YE; Chiu, DC; Fang, JM; Hsu, PH; Jan, JT; Lee, PS; Tsai, KC; Wu, KL	1
Bertagnin, C; Desta, S; Ding, X; Fang, Z; Gao, P; Huang, B; Jia, H; Jia, R; Ju, H; Kang, D; Kong, X; Liang, X; Liu, X; Loregian, A; Lu, H; Lu, X; Ma, X; Murugan, NA; Poongavanam, V; Sun, L; Tian, Y; Xu, W; Zhan, P; Zhang, J	1
Bertagnin, C; Ding, X; Fang, Z; Gao, P; Huang, B; Jia, H; Jia, R; Kang, D; Kong, X; Liu, X; Loregian, A; Ma, X; Murugan, NA; Poongavanam, V; Sun, Z; Tian, Y; Xu, W; Zhan, P; Zhang, J	1
Ding, X; Huang, B; Jia, R; Ju, H; Liu, X; Shang, M; Xiu, S; Zhan, P	1
Ai, W; Cherukupalli, S; Ding, X; Huang, B; Jia, R; Jiang, X; Li, Z; Liu, X; Ma, X; Sun, L; Sun, Z; Wang, D; Zalloum, WA; Zhan, P; Zhang, J	1
Ai, W; Bertagnin, C; Cherukupalli, S; Ding, X; Huang, B; Jia, R; Ju, H; Li, Z; Liu, X; Loregian, A; Ma, X; Zhan, P; Zhang, J	1
Bertagnin, C; Du, R; Guizzo, L; Hou, L; Huang, B; Jia, R; Ju, H; Kang, D; Kong, X; Li, P; Liu, X; Loregian, A; Ma, X; Murugan, NA; Poongavanam, V; Zhan, P; Zhang, Y	1
Bi, Y; Cheng, S; Li, C; Li, X; Lv, X; Wang, P	1
Govorkova, EA; Ilyushina, NA; Rehg, JE; Seiler, JP; Webster, RG	1
Gut, H; Taylor, GL; Walsh, MA; Xu, G	1
Ohuchi, M; Ushirogawa, H	1
Azuma, T; Nakada, N; Tanaka, H; Yamashita, N	1
Chazono, K; Iwajima, Y; Maeda, Y; Nagano, Y; Ohsawa, M; Ono, H; Yamamoto, S	1
Bröjer, C; Gillman, A; Järhult, JD; Latorre-Margalef, N; Lindberg, RH; Muradrasoli, S; Nordh, J; Olsen, B; Söderström, H; Waldenström, J	1
Azuma, T; Inoyama, T; Ishiuchi, H; Mino, Y; Sato, T; Tanaka, H; Teranishi, Y; Yamaoka, M; Yamashita, N	1
Ahn, SJ; Baek, YH; Chae, HB; Choi, WS; Choi, YK; Govorkova, EA; Hwang, J; Jeong, JH; Kim, CJ; Kim, MH; Kwon, HI; Kwon, JJ; Lloren, KKS; Song, MS; Webby, RJ	1
Kolodziej, H; Quosdorf, S; Schuetz, A	1
Liu, GJ; Wang, B; Wang, S; Xing, GW; Yang, X; Zhang, Y	1

Other Studies

33 other study(ies) available for zanamivir and gs 4071

Article	Year
Sialidase inhibitors related to zanamivir: synthesis and biological evaluation of 4H-pyran 6-ether and ketone. Bioorganic & medicinal chemistry letters, 1999, Feb-22, Volume: 9, Issue:4 Topics: Enzyme Inhibitors; Guanidines; Ketones; Neuraminidase; Pyrans; Sialic Acids; Zanamivir	1999
BCX-1812 (RWJ-270201): discovery of a novel, highly potent, orally active, and selective influenza neuraminidase inhibitor through structure-based drug design. Journal of medicinal chemistry, 2000, Sep-21, Volume: 43, Issue:19 Topics: Acids, Carbocyclic; Administration, Oral; Animals; Antiviral Agents; Catalytic Domain; Crystallography, X-Ray; Cyclopentanes; Drug Design; Enzyme Inhibitors; Guanidines; Influenza A virus; Influenza B virus; Mice; Models, Molecular; Neuraminidase; Orthomyxoviridae Infections; Protein Binding; Stereoisomerism; Structure-Activity Relationship	2000
Structural studies of the resistance of influenza virus neuramindase to inhibitors. Journal of medicinal chemistry, 2002, May-23, Volume: 45, Issue:11 Topics: Acetamides; Acids, Carbocyclic; Alphainfluenzavirus; Antiviral Agents; Crystallography, X-Ray; Cyclopentanes; Drug Resistance, Viral; Enzyme Inhibitors; Guanidines; Models, Molecular; Mutation; Neuraminidase; Oseltamivir; Protein Binding; Pyrans; Sialic Acids; Zanamivir	2002
Investigation of neuraminidase-substrate recognition using molecular dynamics and free energy calculations. Journal of medicinal chemistry, 2003, Dec-18, Volume: 46, Issue:26 Topics: Alanine; Antiviral Agents; Binding Sites; Crystallography, X-Ray; Enzyme Inhibitors; Ligands; Models, Molecular; Molecular Conformation; Neuraminidase; Substrate Specificity; Thermodynamics; Viral Core Proteins; Water	2003
QSAR study of neuraminidase inhibitors based on heuristic method and radial basis function network. European journal of medicinal chemistry, 2008, Volume: 43, Issue:3 Topics: Enzyme Inhibitors; Linear Models; Models, Biological; Neuraminidase; Quantitative Structure-Activity Relationship	2008
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Unified QSAR approach to antimicrobials. 4. Multi-target QSAR modeling and comparative multi-distance study of the giant components of antiviral drug-drug complex networks. Bioorganic & medicinal chemistry, 2009, Jan-15, Volume: 17, Issue:2 Topics: Anti-Infective Agents; Antiviral Agents; Artificial Intelligence; Computer Simulation; Drug Evaluation, Preclinical; Molecular Structure; Quantitative Structure-Activity Relationship	2009
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Intramolecular ion-pair prodrugs of zanamivir and guanidino-oseltamivir. Bioorganic & medicinal chemistry, 2011, Aug-15, Volume: 19, Issue:16 Topics: Administration, Oral; Antiviral Agents; Carbon Dioxide; Cell Line; Drug Evaluation, Preclinical; Enzyme Inhibitors; Esters; Guanidine; Humans; Hydrophobic and Hydrophilic Interactions; Influenza A virus; Influenza, Human; Ions; Molecular Structure; Naphthols; Neuraminidase; Oseltamivir; Prodrugs; Zanamivir	2011
Development of oseltamivir phosphonate congeners as anti-influenza agents. Journal of medicinal chemistry, 2012, Oct-25, Volume: 55, Issue:20 Topics: Acetamides; Administration, Oral; Alphainfluenzavirus; Animals; Antiviral Agents; Betainfluenzavirus; Biological Availability; Blood Proteins; Cyclohexenes; Cytopathogenic Effect, Viral; Dogs; Drug Resistance, Viral; Drug Stability; Female; Humans; Influenza A Virus, H1N1 Subtype; Influenza A Virus, H5N1 Subtype; Madin Darby Canine Kidney Cells; Male; Mice; Mice, Inbred BALB C; Microsomes, Liver; Mutation; Neuraminidase; Orthomyxoviridae Infections; Oseltamivir; Phosphorous Acids; Protein Binding; Rats; Structure-Activity Relationship	2012
Optimization of a direct spectrophotometric method to investigate the kinetics and inhibition of sialidases. BMC biochemistry, 2012, Oct-02, Volume: 13 Topics: Biocatalysis; Buffers; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; N-Acetylneuraminic Acid; Neuraminidase; Recombinant Proteins; Spectrophotometry, Ultraviolet; Streptococcus pneumoniae; Substrate Specificity	2012
Development of novel potent orally bioavailable oseltamivir derivatives active against resistant influenza A. Journal of medicinal chemistry, 2014, Feb-13, Volume: 57, Issue:3 Topics: Administration, Oral; Amidines; Animals; Antiviral Agents; Biological Availability; Dogs; Drug Resistance, Viral; Guanidines; Humans; Influenza A Virus, H1N1 Subtype; Influenza A Virus, H3N2 Subtype; Madin Darby Canine Kidney Cells; Male; Molecular Docking Simulation; Mutation; Neuraminidase; Oseltamivir; Prodrugs; Protein Binding; Rats; Rats, Sprague-Dawley; Stereoisomerism; Structure-Activity Relationship; Swine	2014
Peramivir Phosphonate Derivatives as Influenza Neuraminidase Inhibitors. Journal of medicinal chemistry, 2016, 06-09, Volume: 59, Issue:11 Topics: Acids, Carbocyclic; Animals; Antiviral Agents; Cyclopentanes; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanidines; Humans; Influenza, Human; Microbial Sensitivity Tests; Models, Molecular; Molecular Structure; Neuraminidase; Rabbits; Structure-Activity Relationship	2016
Structure-Based Tetravalent Zanamivir with Potent Inhibitory Activity against Drug-Resistant Influenza Viruses. Journal of medicinal chemistry, 2016, 07-14, Volume: 59, Issue:13 Topics: Animals; Antiviral Agents; Crystallography, X-Ray; Dogs; Dose-Response Relationship, Drug; Drug Resistance, Viral; Humans; Influenza A Virus, H3N2 Subtype; Influenza A Virus, H7N9 Subtype; Madin Darby Canine Kidney Cells; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests; Models, Molecular; Molecular Structure; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Zanamivir	2016
Acylguanidine derivatives of zanamivir and oseltamivir: Potential orally available prodrugs against influenza viruses. European journal of medicinal chemistry, 2018, Jun-25, Volume: 154 Topics: Administration, Oral; Antiviral Agents; Dose-Response Relationship, Drug; Hydrophobic and Hydrophilic Interactions; Microbial Sensitivity Tests; Molecular Docking Simulation; Molecular Structure; Orthomyxoviridae; Oseltamivir; Prodrugs; Structure-Activity Relationship; Zanamivir	2018
Optimization of N-Substituted Oseltamivir Derivatives as Potent Inhibitors of Group-1 and -2 Influenza A Neuraminidases, Including a Drug-Resistant Variant. Journal of medicinal chemistry, 2018, Jul-26, Volume: 61, Issue:14 Topics: Cell Line; Drug Design; Drug Resistance, Viral; Enzyme Inhibitors; Female; Humans; Male; Models, Molecular; Mutation; Neuraminidase; Oseltamivir; Protein Conformation; Safety; Viral Proteins	2018
Structure-Based Optimization of N-Substituted Oseltamivir Derivatives as Potent Anti-Influenza A Virus Agents with Significantly Improved Potency against Oseltamivir-Resistant N1-H274Y Variant. Journal of medicinal chemistry, 2018, 11-21, Volume: 61, Issue:22 Topics: Animals; Antiviral Agents; Catalytic Domain; Dogs; Drug Design; Drug Resistance, Viral; Drug Stability; Humans; Influenza A virus; Madin Darby Canine Kidney Cells; Male; Molecular Docking Simulation; Mutation; Neuraminidase; Nitrogen; Oseltamivir; Rats; Tissue Distribution	2018
Discovery of novel 1,2,3-triazole oseltamivir derivatives as potent influenza neuraminidase inhibitors targeting the 430-cavity. European journal of medicinal chemistry, 2020, Feb-01, Volume: 187 Topics: Animals; Antiviral Agents; Chickens; Dose-Response Relationship, Drug; Drug Discovery; Enzyme Inhibitors; Fibroblasts; Influenza A virus; Microbial Sensitivity Tests; Models, Molecular; Molecular Structure; Neuraminidase; Structure-Activity Relationship; Triazoles	2020
Discovery of novel "Dual-site" binding oseltamivir derivatives as potent influenza virus neuraminidase inhibitors. European journal of medicinal chemistry, 2020, Apr-01, Volume: 191 Topics: Animals; Antiviral Agents; Chickens; Dose-Response Relationship, Drug; Drug Discovery; Enzyme Inhibitors; Female; Influenza A virus; Male; Mice; Mice, Inbred Strains; Microbial Sensitivity Tests; Molecular Docking Simulation; Molecular Structure; Neuraminidase; Oseltamivir; Structure-Activity Relationship	2020
Discovery of highly potent and selective influenza virus neuraminidase inhibitors targeting 150-cavity. European journal of medicinal chemistry, 2021, Feb-15, Volume: 212 Topics: Animals; Antiviral Agents; Dose-Response Relationship, Drug; Drug Discovery; Enzyme Inhibitors; Female; Male; Mice; Mice, Inbred Strains; Microbial Sensitivity Tests; Molecular Structure; Neuraminidase; Orthomyxoviridae; Oseltamivir; Structure-Activity Relationship	2021
Identification of C5-NH Journal of medicinal chemistry, 2021, 12-23, Volume: 64, Issue:24 Topics: Animals; Antiviral Agents; Biological Availability; Chick Embryo; Computer Simulation; Half-Life; Influenza A Virus, H5N1 Subtype; Mice; Molecular Docking Simulation; Molecular Dynamics Simulation; Neuraminidase; Oseltamivir; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship	2021
Zanamivir-Cholesterol Conjugate: A Long-Acting Neuraminidase Inhibitor with Potent Efficacy against Drug-Resistant Influenza Viruses. Journal of medicinal chemistry, 2021, 12-09, Volume: 64, Issue:23 Topics: Animals; Antiviral Agents; Cholesterol; Drug Resistance, Viral; Enzyme Inhibitors; Half-Life; Humans; Influenza A Virus, H1N1 Subtype; Mice; Mice, Inbred BALB C; Mutation; Neuraminidase; Rats; Rats, Sprague-Dawley; Virus Replication; Zanamivir	2021
Effect of neuraminidase inhibitor-resistant mutations on pathogenicity of clade 2.2 A/Turkey/15/06 (H5N1) influenza virus in ferrets. PLoS pathogens, 2010, May-27, Volume: 6, Issue:5 Topics: Animals; Antiviral Agents; Cell Line; Crystallography; Disease Models, Animal; Dogs; Drug Resistance, Viral; Enzyme Inhibitors; Ferrets; Humans; Influenza A Virus, H5N1 Subtype; Kidney; Male; Neuraminidase; Orthomyxoviridae Infections; Oseltamivir; Protein Structure, Tertiary; Recombinant Proteins; Zanamivir	2010
Structural basis for Streptococcus pneumoniae NanA inhibition by influenza antivirals zanamivir and oseltamivir carboxylate. Journal of molecular biology, 2011, Jun-17, Volume: 409, Issue:4 Topics: Animals; Antiviral Agents; Carboxylic Acids; Humans; Isoenzymes; Mice; Molecular Sequence Data; Molecular Structure; Neuraminidase; Oseltamivir; Protein Conformation; Streptococcus pneumoniae; Zanamivir	2011
Novel antiviral activity of neuraminidase inhibitors against an avian influenza a virus. Virology journal, 2011, Aug-19, Volume: 8 Topics: Animals; Antiviral Agents; Cell Line; Chickens; Dogs; Humans; Influenza A virus; Influenza in Birds; Influenza, Human; Microscopy, Electron, Scanning; Neuraminidase; Oseltamivir; Virion; Virus Assembly; Zanamivir	2011
Synchronous dynamics of observed and predicted values of anti-influenza drugs in environmental waters during a seasonal influenza outbreak. Environmental science & technology, 2012, Dec-04, Volume: 46, Issue:23 Topics: Amantadine; Antiviral Agents; Disease Outbreaks; Environmental Monitoring; Humans; Influenza, Human; Japan; Oseltamivir; Rivers; Sewage; Water Pollutants, Chemical; Zanamivir	2012
Reduction in sympathetic nerve activity as a possible mechanism for the hypothermic effect of oseltamivir, an anti-influenza virus drug, in normal mice. Basic & clinical pharmacology & toxicology, 2013, Volume: 113, Issue:1 Topics: Animals; Antiviral Agents; Body Temperature; Hexamethonium; Hypothermia; Injections, Intraperitoneal; Injections, Intraventricular; Male; Mecamylamine; Mice; Neuraminidase; Nicotine; Oseltamivir; Zanamivir	2013
Resistance mutation R292K is induced in influenza A(H6N2) virus by exposure of infected mallards to low levels of oseltamivir. PloS one, 2013, Volume: 8, Issue:8 Topics: Animals; Anseriformes; Antiviral Agents; Chick Embryo; Computational Biology; Drug Resistance, Viral; Hemagglutinin Glycoproteins, Influenza Virus; Influenza A virus; Influenza in Birds; Male; Microbial Sensitivity Tests; Mutation; Neuraminidase; Oseltamivir; Water; Zanamivir	2013
Detection of peramivir and laninamivir, new anti-influenza drugs, in sewage effluent and river waters in Japan. PloS one, 2015, Volume: 10, Issue:6 Topics: Acids, Carbocyclic; Antiviral Agents; Cities; Cyclopentanes; Drug Residues; Environmental Monitoring; Guanidines; Japan; Limit of Detection; Oseltamivir; Ozone; Pyrans; Risk Assessment; Rivers; Sewage; Sialic Acids; Water Pollutants, Chemical; Water Purification; Zanamivir	2015
Screening for Neuraminidase Inhibitor Resistance Markers among Avian Influenza Viruses of the N4, N5, N6, and N8 Neuraminidase Subtypes. Journal of virology, 2018, 01-01, Volume: 92, Issue:1 Topics: Acids, Carbocyclic; Amino Acid Substitution; Animals; Antiviral Agents; Birds; Cyclopentanes; Dogs; Drug Resistance, Viral; Enzyme Inhibitors; Guanidines; Humans; Influenza in Birds; Influenza, Human; Madin Darby Canine Kidney Cells; Mutagenesis; Neuraminidase; Orthomyxoviridae; Oseltamivir; Reverse Genetics; Zanamivir	2018
Different Inhibitory Potencies of Oseltamivir Carboxylate, Zanamivir, and Several Tannins on Bacterial and Viral Neuraminidases as Assessed in a Cell-Free Fluorescence-Based Enzyme Inhibition Assay. Molecules (Basel, Switzerland), 2017, Nov-17, Volume: 22, Issue:11 Topics: Anti-Bacterial Agents; Antiviral Agents; Drug Synergism; Enzyme Assays; Hydrolyzable Tannins; Inhibitory Concentration 50; Neuraminidase; Oseltamivir; Tannins; Vibrio cholerae; Viral Proteins; Zanamivir	2017
A tetravalent sialic acid-coated tetraphenylethene luminogen with aggregation-induced emission characteristics: design, synthesis and application for sialidase activity assay, high-throughput screening of sialidase inhibitors and diagnosis of bacterial va Chemical communications (Cambridge, England), 2018, Sep-20, Volume: 54, Issue:76 Topics: Adult; Clostridium perfringens; Enzyme Inhibitors; Female; Fluorescence; Fluorescent Dyes; Fluorometry; High-Throughput Screening Assays; Humans; Hydrophobic and Hydrophilic Interactions; Kinetics; Limit of Detection; Middle Aged; N-Acetylneuraminic Acid; Neuraminidase; Oseltamivir; Sialic Acids; Stilbenes; Vaginosis, Bacterial; Vibrio cholerae; Young Adult; Zanamivir	2018