yohimbine and naloxone
yohimbine has been researched along with naloxone in 221 studies
Research
Studies (221)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 75 (33.94) | 18.7374 |
| 1990's | 74 (33.48) | 18.2507 |
| 2000's | 42 (19.00) | 29.6817 |
| 2010's | 28 (12.67) | 24.3611 |
| 2020's | 2 (0.90) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Billings, J; Chumpradit, S; Kung, HF; Kung, MP; Mach, R | 1 |
| Foulon, C; Kung, HF; Kung, MP | 1 |
| Bartoccini, F; Carminati, P; Castorina, M; Di Cesare, MA; Di Serio, S; Gallo, G; Ghirardi, O; Giorgi, F; Giorgi, L; Minetti, P; Piersanti, G; Tarzia, G; Tinti, MO | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Paalzow, G; Paalzow, L | 1 |
| Gomes, C; Svensson, TH; Trolin, G | 1 |
| Fu, TC; Guo, L; Liu, HJ; Peng, YI | 1 |
| Colado, MI; Martin, MI | 1 |
| Bapna, JS; Ramaswamy, S; Shewade, DG; Tyagi, MG | 1 |
| Ando, R; Kawamura, S; Kimura, Y; Kisara, K; Tadano, T; Yonezawa, A | 1 |
| Montastruc, JL; Montastruc, P; Rascol, O | 1 |
| Dahl, JB; Frigast, C; Jensen, FM | 1 |
| Bojö, L; Cassuto, J | 1 |
| Dawes, P; Rochford, J | 1 |
| Garzón, J; Sánchez-Blázquez, P | 1 |
| Alamo, C; Alguacil, LF; Cuenca, E; Iglesias, V | 1 |
| Gebhart, GF; Zhuo, M | 1 |
| De Sarro, G; Nisticó, G | 1 |
| Kaneto, H; Takahashi, M; Tokuyama, S | 1 |
| Bianchi, G | 1 |
| Burnett, A; Gebhart, GF | 1 |
| Connelly, CD; Hollingworth, RM; Orr, N; Raffa, RB | 1 |
| Morrone, LA; Pimpinella, G; Romanelli, L; Valeri, P | 1 |
| Martinelli, B; Morrone, LA; Severini, C; Valeri, P | 1 |
| Dai, S; Wang, Y | 1 |
| Azerad, J; Desmonts, JM; Limoge, A; Mantz, J | 1 |
| Foo, H; Westbrook, RF | 1 |
| Fitzpatrick, D; Graber, B; Hendricks, S; Koskinen, I; Yells, D | 1 |
| Borisova, EV; Kadar, T; Telegdi, G | 1 |
| Wong, CL | 2 |
| Miller, JF; Proudfit, HK | 1 |
| Collins, KA; Tseng, LF | 1 |
| Raffa, RB; Vaught, JL | 1 |
| Elsworth, JD; Lewis, VO; Pivirotto, P; Redmond, DE; Roth, RH; Taylor, JR | 1 |
| Englberger, W; Friderichs, E; Reimann, W; Schneider, J | 1 |
| Kreeger, TJ; Seal, US | 1 |
| Tang, R; Tseng, LF | 1 |
| Hong, M; Jhamandas, K; Loomis, C; Milne, B | 1 |
| Defaux, JP; Junien, JL; Pascaud, X; Rozé, C | 1 |
| Hopper, DL; Hsu, WH; Schaffer, DD | 1 |
| Collins, JG; Kitahata, LM; Murata, K; Nakagawa, I; Omote, K | 1 |
| Nance, PW; Sawynok, J | 1 |
| Goode, TL; Raffa, RB; Scott, RW | 1 |
| Ansuategui, M; Feria, M; Naharro, L | 1 |
| Fujimoto, JM; Suh, HH; Tseng, LL | 1 |
| Kanda, A; Kimura, T; Koyanagawa, H; Musha, T; Satoh, S | 1 |
| Tang, R; Tseng, LL | 1 |
| Couture, R; Laneuville, O; Reader, TA | 1 |
| Baba, S; Takeda, T; Tanaka, C; Taniyama, K | 1 |
| Martínez, JA; Milanés, MV; Vargas, ML | 1 |
| Eaker, EY; Sninsky, CA | 1 |
| Jones, LF; Tackett, RL | 1 |
| Jones, LF; Laskey, RE; Tackett, RL | 1 |
| Butkhuzi, SM; Kolchin, VV; Moroz, BT; Sakvarelidze, ZA; Zaĭtsev, AA | 1 |
| Bansinath, M; Puig, MM; Ramabadran, K; Turndorf, H | 1 |
| Hatch, RC; Jernigan, AD | 1 |
| Blythe, BL; Koch, PC; Peters, RH | 1 |
| Bicknell, RJ; Brown, D; Chapman, C; Zhao, BG | 1 |
| Kulkarni, SK; Parale, MP | 1 |
| Dollery, CT; Struthers, AD | 1 |
| Gebhart, GF; Ossipov, MH | 1 |
| Ben-Zvi, Z; Hurwitz, A | 1 |
| Gebhart, GF; Janss, AJ | 1 |
| Emi, S; Hikasa, Y; Ogasawara, S; Takase, K | 1 |
| Harris, JC; Newman, JD | 1 |
| Beckel, M; Callahan, M; Kreeger, TJ; Mandsager, RE; Seal, US | 1 |
| Martinelli, B; Pimpinella, G; Severini, C; Valeri, P | 1 |
| Knudtzon, J | 1 |
| Garcia, MC; Kenney, RM; McDonnell, SM | 1 |
| Dashwood, MR; Gilbey, MP; Spyer, KM | 1 |
| Reny-Palasse, V; Rips, R | 1 |
| Rae, GA; Souza, RL; Takahashi, RN | 1 |
| Booth, NH; Brown, J; Clark, JD; Hatch, RC; Jernigan, AD; Lipham, IB; Wilson, RC | 1 |
| Charney, DS; Heninger, GR | 1 |
| Hölting, T; Limberger, N; Späth, L; Starke, K | 1 |
| Ingenito, AJ; Mastrianni, JA | 1 |
| Dashwood, MR; Dickenson, AH; Sullivan, AF | 1 |
| Ferreira, SH; Nakamura, M | 1 |
| Gebhart, GF; Solomon, RE | 1 |
| Gall, M; McCall, JM; Mohrland, JS; TenBrink, RE; Von Voigtlander, PF | 1 |
| Adithan, C; Bapna, JS; Shashindran, CH; Sivagnanam, G; Swain, R | 1 |
| Bapna, JS; Ramaswamy, S | 1 |
| Brown, OM; DiStefano, PS | 1 |
| Adithan, C; Bapna, JS; Raveendran, R; Sivagnanam, G; Thakur, LC | 1 |
| Clark, R; Clark, WE; Jessup, DA; Jones, KR; Lance, WR | 1 |
| Mohrland, JS; Von Voigtlander, PF | 1 |
| Collier, HO; Tucker, JF | 1 |
| Hamilton, TC; Longman, SD | 1 |
| Wright, M | 1 |
| Booth, NH; Crawford, LM; Hatch, RC | 1 |
| Rhodes, KF | 1 |
| Coderre, TJ; Rollman, GB | 1 |
| Clark, JD; Hatch, RC; Kitzman, JV; Zahner, JM | 1 |
| Farsang, C; Kunos, G; Mucci, L; Ramirez-Gonzalez, MD | 1 |
| Fielding, S; Lal, H; Spaulding, TC | 1 |
| Chariot, J; Rozé, C; Vaille, C | 1 |
| Chan, HK; Chen, CF; Lin, MT; Teh, GW | 1 |
| Aceto, MD; May, EL | 1 |
| Blank, MS; Diez, JA; Roberts, DL | 1 |
| Atlas, D; Hynes, MD; Ruffolo, RR | 1 |
| Bardo, MT; Bhatnagar, RK; Gebhart, GF | 1 |
| Harden, TK; Smith, MM | 1 |
| Chen, CF; Chuang, KS; Lin, MT | 1 |
| Fregly, MJ; Rowland, N; Wilson, KM | 1 |
| Aleixandre, MA; García de Jalón, PD; Martin, MI | 1 |
| Booth, NH; Clark, JD; Hatch, RC; Kitzman, JV | 1 |
| Dwoskin, LP; Neal, BS; Sparber, SB | 1 |
| Livingston, A; Low, J; Morris, B | 1 |
| Chipkin, RE; Latranyi, MB | 1 |
| Barry, H; Krimmer, EC; McGuire, MS | 1 |
| Sanger, DJ | 1 |
| Blumberg, H; Slovak, DM | 1 |
| Gupta, VN; Pickworth, WB; Sharpe, LG | 1 |
| Boucher, F; Dennis, SG; Gutman, S; Melzack, R | 1 |
| Bastide, P; Coudert, P; Rubat, C; Tronche, P | 1 |
| Beleslin, DB; Jovanović-Mićić, D; Samardzić, R | 1 |
| Capasso, A; Di Giannuario, A; Loizzo, A; Pieretti, S; Sorrentino, L | 1 |
| Chakrabarti, MK; Knowles, MG; Wang, C; Whitwam, JG | 1 |
| Lasova, LS; Mutafova-Yambolieva, VN; Venkova, KM | 1 |
| Agnati, LF; Frasoldati, A; Grimaldi, R; Marrama, P; Pich, EM; Zini, I | 1 |
| Driessen, B; Illes, P; Nieber, K; Sevcik, J | 1 |
| Onoda, Y; Yamada, K | 1 |
| Dhawan, BN; Kumar, A; Raghubir, R | 1 |
| Dawes, P; Rochford, J; Stewart, J | 1 |
| Driessen, B; Giertz, H; Reimann, W | 1 |
| Fernández-Guasti, A; Rodríguez-Manzo, G | 1 |
| Choi, YS; Do, JC; Kim, YH; Lee, KH; Son, KH; Song, DK; Suh, HW; Woo, MH | 1 |
| Brill, T; Erhardt, W; Henke, J; Lendl, C; Matis, U; Otto, K; Roberts, U | 1 |
| Fang, F; Proudfit, HK | 1 |
| Collart, L; Dayer, P; Desmeules, JA; Piguet, V | 1 |
| Gergen, KA; Kastin, AJ; Paul, D; Zadina, JE | 1 |
| Fujinaga, M; Golden, W; Guo, TZ; Maze, M; Poree, L; Stein, J | 1 |
| Miranda, HF; Naquira, D; Pinardi, G; Sierralta, F | 1 |
| Aley, KO; Levine, JD | 1 |
| Dziki, AJ; Ferguson, JL; Krahmer, R; Law, WR; Lynch, WH; Mourelatos, MG | 1 |
| Bombelli, R; Cosentino, M; Ferrari, M; Frigo, G; Giaroni, C; Lecchini, S; Marino, F; Rasini, E | 1 |
| Asai, T; Mapleson, WW; Power, I | 1 |
| Hameedi, FA; Kosten, TR; Pearsall, HR; Rosen, MI; Woods, SW | 1 |
| Asai, T; Power, I; Vickers, MD | 1 |
| Bugajski, J; Gadek-Michalska, A | 1 |
| Inagaki, Y; Mashimo, T; Ohara, A; Shibuta, S; Yoshiya, I; Zhang, P | 1 |
| Davies, MF; Fang, F; Guo, TZ; Maze, M | 1 |
| Alloui, A; Berger, V; Dubray, C; Eschalier, A; Kemeny, JL; Lavarenne, J | 1 |
| Hiruma, Y; Matsui, Y; Matsutani, K; Tsuruoka, M | 1 |
| Getslev, V; Pick, CG; Schreiber, S; Weizman, A | 1 |
| Virag, L; Vulliemoz, Y; Whittington, RA | 1 |
| Bois, F; Coudert, P; Couquelet, J; Moreau, S; Rubat, C | 1 |
| Rao, VS; Santos, FA | 1 |
| Bugajski, J; Cetera, B; Gadek-Michalska, A | 1 |
| de Wolff, MH; Leather, HA; Wouters, PF | 1 |
| Fuertes, G; González-Cuello, A; Laorden, ML; Milanés, MV | 1 |
| Bebot, M; Coudert, P; Couquelet, J; Courteix, C; Fialip, J; Rubat, C | 1 |
| Chen, JY; Dafny, N; Kang, YM; Ouyang, W; Qiao, JT | 1 |
| Bartolini, A; Galeotti, N; Ghelardini, C | 1 |
| Anderson, GM; Bremner, JD; Carpenter, LL; Charney, DS; Halaszynski, TM; Heninger, GR; Nemeroff, CB; Owens, MJ; Vythilingam, M | 1 |
| Gore, AC; Terasawa, E | 1 |
| Abouazra, HA; Sharif, SI | 1 |
| Schiller, PW; Shimoyama, M; Shimoyama, N; Szeto, HH; Zhao, GM | 1 |
| Capasso, F; Capasso, R; Di Carlo, G; Izzo, AA; Mascolo, N; Pinto, L | 1 |
| Beitz, AJ; Han, HJ; Kang, MS; Kwon, YB; Lee, JH | 1 |
| Arad, MA; Dehpour, AR; Namiranian, K; Samini, M | 1 |
| Capasso, F; Capasso, R; Di Marzo, V; Fezza, F; Izzo, AA; Mascolo, N; Pinto, A | 1 |
| Adeghate, E; Ponery, AS | 1 |
| Fayaz-Dastgerdi, M; Homayoun, H; Khavandgar, S; Zarrindast, MR | 1 |
| Azizi, MR; Dehpour, AR; Farahani, M; Javidan, AN; Namiranian, K; Sadr, SS | 1 |
| Hayashi, M; Hoshi, K; Ichihara, K; Nakai, T; Wakabayashi, H | 1 |
| Choi, SS; Han, EJ; Han, KJ; Lee, HK; Lee, JK; Lee, TH; Suh, HW | 1 |
| Benios, T; Feingold, A; McCance-Katz, E; Oliveto, A; Poling, J; Sevarino, K | 1 |
| Alguacil, LF; Herradón, G; Morales, L; Pérez-García, C | 1 |
| Choi, SS; Han, EJ; Han, KJ; Kim, DH; Lee, HK; Lee, JK; Suh, HW | 1 |
| Sahebgharani, M; Vousooghi, N; Zarrindast, MR | 1 |
| Assadi, E; Oryan, S; Sahebgharani, M; Torkaman-Boutorabi, A; Zarrindast, MR | 1 |
| Radhakrishnan, R; Rohlwing, JJ; Skyba, DA; Sluka, KA; Wright, A | 1 |
| Aricioglu, F; Dulger, G; Ercil, E | 1 |
| Aricioglu, F; Utkan, T | 1 |
| Aviles, M; González-Cuello, A; Laorden, ML; Milanés, MV | 1 |
| Fournier, NM; Galic, MA; Martin, LJ | 1 |
| Maor, Y; Mechoulam, R; Pertwee, RG; Stevenson, LA; Thomas, A | 1 |
| Fülöp, K; Gyires, K; Rónai, AZ; Zádori, Z | 1 |
| Baek, YH; Choi, DY; Huh, JE; Lee, JD; Park, DS | 1 |
| Campos, AR; David, JM; David, JP; Lima-Júnior, RC; Maia, JL; Melo, CM; Rao, VS; Santos, FA | 1 |
| Cardinaletti, C; Carrieri, A; Gentili, F; Ghelfi, F; Mattioli, L; Perfumi, M; Pigini, M; Vesprini, C | 1 |
| Hama, A; Sagen, J | 1 |
| Honda, M; Ono, H; Ono, K; Takasu, K; Tanabe, M; Tokuda, Y | 1 |
| Ardenghi, JV; De Souza, MM; Filho, VC; Kanegusuku, M; Monache, FD; Niero, R; Yunes, RA | 1 |
| Li, CL; Li, RT; Sun, Q; Ye, J; Yue, CQ | 1 |
| de Castro Perez, A; de Francischi, JN; Gama Duarte, ID; Romero, TR | 1 |
| Ding, Z; Raffa, RB | 1 |
| Bilge, SS; Bostanci, MO; Bozkurt, A; Ciftcioglu, E; Dilek, A; Güldogus, F; Ilkaya, F; Ulger, F | 1 |
| Doihara, H; Ito, H; Kawabata-Shoda, E; Kojima, R; Nozawa, K; Yokoyama, T | 1 |
| Pettersen, VL; Raimundo, JM; Sudo, RT; Trachez, MM; Zapata-Sudo, G | 1 |
| Hsu, SF; Huang, YJ; Li, YL; Sun, WZ; Wang, CC; Wen, YR; Yeh, GC | 1 |
| Heydari, F; Mehr, SE; Samini, M | 1 |
| Christoph, T; Jahnel, U; Schröder, W; Tzschentke, TM; Vry, JD | 1 |
| Hajhashemi, V; Minaiyan, M; Movahedian, A; Sadeghi, H; Talebi, A | 1 |
| Bhalla, S; Gulati, A; Rapolaviciute, V | 1 |
| Andoh, T; Gotoh, Y; Kuraishi, Y; Omori, Y | 1 |
| Du, JQ; Li, Q; Liu, XH; Sun, N; Tang, JS; Zhu, JX | 1 |
| Hagiwara, S; Iwasaka, H; Noguchi, T; Okuda, K; Takatani, J; Takeshima, N; Uchino, T | 1 |
| Andurkar, SV; Gulati, A | 1 |
| Micov, AM; Paranos, SLj; Stepanović-Petrović, RM; Tomić, MA | 1 |
| Bujalska-Zadrożny, M; Cegielska-Perun, K; Gąsińska, E; Makulska-Nowak, HE; Tatarkiewicz, J | 1 |
| Abrahão, RQ; Andrade, D; Dale, CS; Franciosi, AC; Giorgi, R; Juliano, L; Juliano, MA | 1 |
| Christoph, T; Cowan, A; Raffa, RB; Schröder, W; Tallarida, CS; Tallarida, RJ; Tzschentke, TM | 1 |
| Leri, F; Minhas, M | 1 |
| Caselli, G; Ferrari, F; Lanza, M; Menghetti, I; Tremolada, D | 1 |
| Li, G; Li, X; Ma, C; Wan, Q; Wu, S; Yu, D; Zhang, B; Zhou, R | 1 |
| Alexandre-Moreira, MS; Barbosa-Filho, JM; Cavalcante-Silva, LH; da Silva, TM; de Araújo-Júnior, JX; de Miranda, GE; Falcão, MA; Noël, F; Santos, BV; Sousa, JC; Viana, MD; Vieira, AC | 1 |
| Dickenson, AH; Friend, LV; Gonçalves, L | 1 |
| Du, JQ; Han, M; Liu, XH | 1 |
| Batisti, AP; Carlesso, MG; Donatello, N; dos Santos, AR; Emer, AA; Martins, DF; Mazzardo-Martins, L; Micke, GA; Piovezan, AP; Pizzolatti, MG; Venzke, D | 1 |
| Abd El-Aty, AM; Cho, SH; Cho, SM; Kim, JS; Kim, SK; Park, JA; Shim, JH; Shin, HC; Yi, H; Zhang, D | 1 |
| Farooq, U; İdris, M; Malik, H; Sajjad, S; Tobassum, S | 1 |
| Coutinho, HD; de Albuquerque, TR; de Lacerda Neto, LJ; de Menezes, IR; de Oliveira, LR; de Souza, SD; Dos Santos, AT; Kerntopf, MR; Quintans-Júnior, LJ; Ramos, AG; Santos Sales, V; Wanderley, AG | 1 |
| Aktumsek, A; Antoniolli, AR; Araújo, AAS; Araújo-Filho, HG; Brito, RG; Coutinho, HDM; Lucchesi, A; Menezes, IRA; Menezes, PP; Quintans, JSS; Quintans-Júnior, LJ; Santos, PL; Scotti, L; Scotti, MT; Siqueira-Lima, PS; Zengin, G | 1 |
| Micov, A; Pecikoza, U; Stepanović-Petrović, R; Tomić, M | 1 |
| Fricova, J; Nedvidek, J; Rokyta, R | 1 |
| Good, GM; Oraebosi, MI | 1 |
| Choi, GJ; Kang, H; Kwon, JW; Lee, OH | 1 |
Reviews
3 review(s) available for yohimbine and naloxone
| Article | Year |
|---|---|
Central nervous system mechanisms in blood pressure control.
Topics: Adrenergic beta-Antagonists; Animals; Antihypertensive Agents; Blood Pressure; Catecholamines; Clonidine; Disease Models, Animal; Ganglia, Sympathetic; Half-Life; Hypothalamus; Models, Neurological; Naloxone; Neurons; Nitroprusside; Norepinephrine; Phenylethanolamine N-Methyltransferase; Pressoreceptors; Propranolol; Rats; Rats, Inbred SHR; Receptors, Opioid; Reflex; Splanchnic Nerves; Thiophenes; Yohimbine | 1985 |
Sites and mechanisms of dependence in the myenteric plexus of guinea pig ileum.
Topics: Acetylcholine; Adenosine; Animals; Clonidine; Cyclic AMP; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Morphine; Morphine Dependence; Morphine Derivatives; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Naloxone; Pertussis Vaccine; Scopolamine; Substance P; Substance Withdrawal Syndrome; Substance-Related Disorders; Theophylline; Yohimbine | 1984 |
Pharmacologic effects of ketamine and its use in veterinary medicine.
Topics: Amphetamine; Anesthesia; Animals; Antipsychotic Agents; Brain; Cardiovascular System; Cats; Cattle; Cercopithecidae; Chick Embryo; Chickens; Diazepam; Dogs; Female; Goats; Horses; Humans; Ketamine; Liver; Naloxone; Neostigmine; Phenothiazines; Physostigmine; Pregnancy; Rats; Respiratory System; Sheep; Xylazine; Yohimbine | 1982 |
Trials
5 trial(s) available for yohimbine and naloxone
| Article | Year |
|---|---|
Alpha 2-adrenergic and opiate receptor blockade. Synergistic effects on anxiety in healthy subjects.
Topics: Adult; Anxiety Disorders; Drug Synergism; Erectile Dysfunction; Female; Humans; Hydrocortisone; Male; Methoxyhydroxyphenylglycol; Naloxone; Receptors, Adrenergic, alpha; Receptors, Opioid; Yohimbine | 1986 |
Contribution of monoaminergic modulation to the analgesic effect of tramadol.
Topics: Adrenergic alpha-Antagonists; Adult; Analgesics, Opioid; Drug Interactions; Humans; Male; Naloxone; Narcotic Antagonists; Pain Measurement; Tramadol; Yohimbine | 1996 |
Dose dependent effects of yohimbine on methadone maintained patients.
Topics: Administration, Oral; Adrenergic alpha-Antagonists; Adult; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; In Vitro Techniques; Male; Methadone; Middle Aged; Naloxone; Narcotic Antagonists; Narcotics; Substance Withdrawal Syndrome; Substance-Related Disorders; Yohimbine | 1997 |
Cerebrospinal fluid corticotropin-releasing hormone in healthy humans: effects of yohimbine and naloxone.
Topics: Adult; Analysis of Variance; Corticotropin-Releasing Hormone; Female; Humans; Hydrocortisone; Kinetics; Male; Naloxone; Neurons; Norepinephrine; Reference Values; Time Factors; Yohimbine | 2000 |
Clonidine and yohimbine in opioid-dependent humans responding under a naloxone novel-response discrimination procedure.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adult; Clonidine; Discrimination, Psychological; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Naloxone; Narcotic Antagonists; Opioid-Related Disorders; Surveys and Questionnaires; Yohimbine | 2003 |
Other Studies
213 other study(ies) available for yohimbine and naloxone
| Article | Year |
|---|---|
Fluorinated and iodinated dopamine agents: D2 imaging agents for PET and SPECT.
Topics: Animals; Benzamides; Dopamine Agents; Dopamine D2 Receptor Antagonists; Fluorine Radioisotopes; Iodine Radioisotopes; Macaca fascicularis; Male; Pyrrolidines; Radionuclide Imaging; Rats; Rats, Sprague-Dawley; Tissue Distribution; Tomography, Emission-Computed; Tomography, Emission-Computed, Single-Photon | 1993 |
Synthesis of (R,S)-2'-trans-7-hydroxy-2-[N-n-propyl-N-(3'-iodo-2'- propenyl)-amino]tetralin (trans-7-OH-PIPAT): a new D3 dopamine receptor ligand.
Topics: Binding Sites; Dopamine Agents; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Dopamine D3; Salicylamides; Stereoisomerism; Tetrahydronaphthalenes | 1993 |
2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine and analogues as A2A adenosine receptor antagonists. Design, synthesis, and pharmacological characterization.
Topics: Adenine; Adenosine A2 Receptor Antagonists; Animals; Cell Line; Cricetinae; Cricetulus; Drug Design; Humans; Imidazoles; Male; Models, Molecular; Motor Activity; Purines; Radioligand Assay; Rats; Rats, Inbred F344; Structure-Activity Relationship; Triazoles | 2005 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
Clonidine antinociceptive activity: effects of drugs influencing central monoaminergic and cholinergic mechanisms in the rat.
Topics: 5-Hydroxytryptophan; Analgesia; Animals; Atropine; Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide; Brain Chemistry; Chlorpromazine; Clonidine; Electroshock; Fenclonine; Lysergic Acid Diethylamide; Male; Methyltyrosines; Naloxone; Parasympathetic Nervous System; Phenoxybenzamine; Rats; Receptors, Adrenergic; Receptors, Cholinergic; Reserpine; Sympathetic Nervous System; Vocalization, Animal; Yohimbine | 1976 |
Evidence for involvement of central noradrenergic neurons in the cardiovascular depression induced by morphine in the rat.
Topics: Adrenergic Fibers; Animals; Blood Pressure; Brain; Cardiovascular System; Clonidine; Heart Rate; Male; Morphine; Naloxone; Norepinephrine; Protriptyline; Rats; Reflex; Yohimbine | 1976 |
Mechanisms of adrenaline-induced antinociception in mice.
Topics: Analgesics; Animals; Epinephrine; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Naloxone; Pain; Prazosin; Propranolol; Sensory Thresholds; Yohimbine | 1992 |
Effects of opioid and alpha 2-adrenoceptor agonists on the isolated ileum of morphine-dependent guinea-pigs during withdrawal and after clonidine treatment.
Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Drug Tolerance; Electric Stimulation; Guinea Pigs; Ileum; Male; Morphine; Morphine Dependence; Myenteric Plexus; Naloxone; Narcotics; Neuromuscular Junction; Substance Withdrawal Syndrome; Yohimbine | 1992 |
Further studies on the anti-nociceptive effect of vasopressin.
Topics: Analgesics; Animals; Arginine Vasopressin; Clonidine; Male; Mice; Naloxone; Yohimbine | 1992 |
Chronic clonidine treatment and its termination: effects on penile erection and ejaculation in the dog.
Topics: Adrenergic alpha-Antagonists; Animals; Clonidine; Dogs; Ejaculation; Imidazoles; Male; Naloxone; Penile Erection; Receptors, Adrenergic, alpha; Receptors, Opioid; Yohimbine | 1992 |
Naloxone or haloperidol but not yohimbine reverse apomorphine-induced respiratory depression.
Topics: Animals; Apomorphine; Dogs; Drug Interactions; Female; Haloperidol; Injections, Intravenous; Male; Naloxone; Respiratory Insufficiency; Vomiting; Yohimbine | 1992 |
Direct spinal effect of intrathecal acetaminophen on visceral noxious stimulation in rabbits.
Topics: Acetaminophen; Animals; Catheters, Indwelling; Colon; Dilatation; Dose-Response Relationship, Drug; Electric Stimulation; Female; Injections, Intravenous; Injections, Spinal; Naloxone; Pain Threshold; Placebos; Rabbits; Single-Blind Method; Time Factors; Yohimbine | 1992 |
Gastric reflex relaxation by colonic distension.
Topics: Anesthesia; Animals; Colon; Gastrointestinal Motility; Muscle Tonus; Naloxone; Potassium Chloride; Prazosin; Pressure; Propranolol; Rats; Rats, Inbred Strains; Reflex; Vagotomy; Yohimbine | 1992 |
Clonidine and yohimbine modulate the effects of naloxone on novelty-induced hypoalgesia.
Topics: Animals; Clonidine; Environment; Male; Naloxone; Pain; Rats; Rats, Inbred Strains; Reaction Time; Yohimbine | 1992 |
alpha N-acetyl human beta-endorphin-(1-31) alleviates the morphine withdrawal syndrome in rodents: a comparative study with clonidine.
Topics: Animals; beta-Endorphin; Clonidine; Disease Models, Animal; Male; Mice; Morphine; Naloxone; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome; Yohimbine | 1992 |
Effects of yohimbine on morphine analgesia and physical dependence in the rat.
Topics: Analgesia; Animals; Behavior, Animal; Delayed-Action Preparations; Male; Morphine; Morphine Dependence; Naloxone; Rats; Rats, Inbred Strains; Yohimbine | 1992 |
Tonic cholinergic inhibition of spinal mechanical transmission.
Topics: Animals; Biogenic Monoamines; Cholinergic Antagonists; Drug Interactions; Endorphins; Hot Temperature; Injections, Spinal; Male; Morphine; Naloxone; Pain Measurement; Parasympatholytics; Physical Stimulation; Prazosin; Rats; Rats, Inbred Strains; Reaction Time; Receptors, Adrenergic; Spinal Cord; Synaptic Transmission; Tail; Yohimbine | 1991 |
Effects of pertussis toxin, dibutyryl-cyclic-AMP, bromo-cyclic-AMP and forskolin on the behavioural and electrocortical power spectrum changes induced by microinfusion of interleukin-2 into the locus coeruleus.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenylate Cyclase Toxin; Animals; Antibodies, Monoclonal; Behavior, Animal; Bucladesine; Colforsin; Dose-Response Relationship, Drug; Electroencephalography; Humans; Interleukin-2; Locus Coeruleus; Male; Microinjections; Naloxone; Pertussis Toxin; Rats; Rats, Inbred Strains; Recombinant Proteins; Virulence Factors, Bordetella; Yohimbine | 1991 |
Participation of an alpha 2-mediated mechanism in the production of forced swimming-stress induced analgesia in mice.
Topics: Analgesia; Animals; Clonidine; Drug Tolerance; Male; Mice; Naloxone; Physical Exertion; Receptors, Adrenergic, alpha; Stress, Physiological; Swimming; Yohimbine | 1991 |
Antidiuretic effect of bremazocine and U-50,488 in rats after alpha 2-adrenoceptor blockade.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adrenergic alpha-Antagonists; Animals; Benzomorphans; Dioxanes; Diuresis; Dose-Response Relationship, Drug; Idazoxan; Male; Naloxone; Pyrrolidines; Rats; Rats, Inbred Strains; Yohimbine | 1991 |
Characterization of descending modulation of nociception from the A5 cell group.
Topics: Animals; Atropine; Blood Pressure; Brain Stem; Cardiovascular Physiological Phenomena; Electric Stimulation; Glutamates; Glutamic Acid; Heart Rate; Injections, Spinal; Male; Methysergide; Microinjections; Naloxone; Nociceptors; Phentolamine; Prazosin; Rats; Rats, Inbred Strains; Reaction Time; Yohimbine | 1991 |
XAMI and DCDM, agonists at cAMP-associated octopamine receptors in cockroach nerve cord, produce centrally mediated antinociception in mice.
Topics: Adenylyl Cyclase Inhibitors; Administration, Oral; Adrenergic alpha-Antagonists; Analgesics; Animals; Chlorphenamidine; Cyclic AMP; Dioxanes; Drug Interactions; Idazoxan; Imidazoles; In Vitro Techniques; Injections, Intraventricular; Injections, Spinal; Injections, Subcutaneous; Mice; Naloxone; Octopamine; Periplaneta; Phenylephrine; Rats; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Receptors, Biogenic Amine; Yohimbine | 1991 |
Some pharmacological characteristics of the guinea pig ileum opioid system activated by cholecystokinin.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Atropine; Cholecystokinin; Clonidine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphine; Muscle Contraction; Muscle, Smooth; Naloxone; Nifedipine; Receptors, Opioid; Yohimbine | 1990 |
Reproducible withdrawal contractions of isolated guinea-pig ileum after brief morphine exposure: effects of clonidine and nifedipine.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Acetylcholine; Animals; Clonidine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphine; Muscle Contraction; Muscle, Smooth; Naloxone; Nifedipine; Substance Withdrawal Syndrome; Yohimbine | 1990 |
Naloxone-induced cardiovascular depression in rats that had received chronic morphine-treatment.
Topics: Anesthesia; Animals; Arteries; Atropine; Blood Pressure; Cardiac Complexes, Premature; Clonidine; Heart; Hemodynamics; In Vitro Techniques; Male; Morphine; Muscle, Smooth, Vascular; Naloxone; Rats; Rats, Inbred Strains; Tail; Yohimbine | 1991 |
Transcranial electrical stimulation with Limoge's currents decreases halothane requirements in rats. Evidence for the involvement of endogenous opioids.
Topics: Anesthesia, Inhalation; Animals; Electric Stimulation; Enkephalins; Halothane; Male; Methysergide; Naloxone; Neprilysin; Rats; Rats, Inbred Strains; Ritanserin; Thiorphan; Yohimbine | 1992 |
Naloxone-induced hypoalgesia: effects of noradrenergic antagonists and agonist.
Topics: Animals; Clonidine; Hot Temperature; Male; Naloxone; Norepinephrine; Pain; Prazosin; Propranolol; Rats; Rats, Inbred Strains; Sensory Thresholds; Yohimbine | 1991 |
Yohimbine and naloxone: effects on male rat sexual behavior.
Topics: Animals; Copulation; Drug Interactions; Ejaculation; Male; Naloxone; Rats; Rats, Inbred Strains; Sexual Behavior, Animal; Yohimbine | 1991 |
Neuropeptide Y and catecholamine-mediated neuronal transmission in mechanisms of feeding-behaviour induction.
Topics: Animals; Feeding Behavior; Naloxone; Neuropeptide Y; Prazosin; Propranolol; Rats; Rats, Wistar; Yohimbine | 1991 |
Interaction between the inhibitory effects of morphine and clonidine on intestinal transit in mice.
Topics: Animals; Clonidine; Dose-Response Relationship, Drug; Drug Antagonism; Drug Interactions; Female; Gastrointestinal Transit; Intestines; Mice; Mice, Inbred ICR; Morphine; Naloxone; Time Factors; Yohimbine | 1991 |
The possible involvement of alpha-adrenoceptors in the intestinal effect of nalbuphine in mice.
Topics: Animals; Benzomorphans; Female; Gastrointestinal Transit; Mice; Mice, Inbred ICR; Nalbuphine; Naloxone; Narcotic Antagonists; Phentolamine; Receptors, Adrenergic, alpha; Yohimbine | 1990 |
Antagonism of stimulation-produced antinociception from ventrolateral pontine sites by intrathecal administration of alpha-adrenergic antagonists and naloxone.
Topics: Adrenergic alpha-Antagonists; Animals; Dioxanes; Dopamine beta-Hydroxylase; Electric Stimulation; Female; Injections, Spinal; Methysergide; Microinjections; Naloxone; Neurons; Pain; Phentolamine; Pons; Propranolol; Rats; Rats, Inbred Strains; Reaction Time; Yohimbine | 1990 |
Different mechanisms mediating tail-flick inhibition induced by beta-endorphin, DAMGO and morphine from ROb and GiA in anesthetized rats.
Topics: Analgesia; Animals; beta-Endorphin; Brain Stem; Diffusion; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Methysergide; Morphine; Naloxone; Raphe Nuclei; Rats; Rats, Inbred Strains; Yohimbine | 1991 |
Centrally-mediated antinociceptive action of RWJ-22757 (formerly McN-5195): involvement of spinal descending inhibitory pathways (an hypothesis).
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Drug Interactions; Indolizines; Injections, Intraventricular; Injections, Spinal; Male; Methysergide; Mice; Morphine; Naloxone; Phentolamine; Rats; Rats, Inbred Strains; Spinal Cord; Yohimbine | 1991 |
Yohimbine co-treatment during chronic morphine administration attenuates naloxone-precipitated withdrawal without diminishing tail-flick analgesia in rats.
Topics: Analgesics; Animals; Behavior, Animal; Drug Implants; Male; Morphine; Naloxone; Rats; Rats, Inbred Strains; Reaction Time; Substance Withdrawal Syndrome; Yohimbine | 1991 |
Analgesic and antitussive properties of EM 405.
Topics: Analgesia; Animals; Antitussive Agents; Brain; Cell Membrane; Cough; Cyclohexanes; Cyclohexenes; Guinea Pigs; Hypothalamus; Morphine; Naloxone; Norepinephrine; Rats; Synaptosomes; Yohimbine | 1991 |
Immobilization of gray wolves (Canis lupus) with sufentanil citrate.
Topics: Anesthetics; Animals; Arousal; Carnivora; Etorphine; Female; Fentanyl; Immobilization; Male; Naloxone; Sufentanil; Xylazine; Yohimbine | 1990 |
Different mechanisms mediate beta-endorphin- and morphine-induced inhibition of the tail-flick response in rats.
Topics: Analgesia; Animals; beta-Endorphin; Efferent Pathways; Male; Microinjections; Morphine; Naloxone; Periaqueductal Gray; Rats; Rats, Inbred Strains; Receptors, Opioid; Yohimbine | 1990 |
In vivo catechol activity in the locus coeruleus following nociception, naloxone, and yohimbine.
Topics: Animals; Arousal; Locus Coeruleus; Male; Naloxone; Nociceptors; Norepinephrine; Rats; Receptors, Adrenergic; Receptors, Opioid; Reflex; Spinal Cord; Yohimbine | 1990 |
Effect of selective sigma ligands on duodenal alkaline secretion in the rat.
Topics: Animals; Atropine; Bicarbonates; Dose-Response Relationship, Drug; Duodenum; Guanidines; Haloperidol; Injections, Intravenous; Intestinal Mucosa; Intestinal Secretions; Male; Naloxone; Phenazocine; Prazosin; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, sigma; Yohimbine | 1990 |
The effects of yohimbine and four other antagonists on amitraz-induced depression of shuttle avoidance responses in dogs.
Topics: Animals; Atropine; Avoidance Learning; Central Nervous System; Dogs; Injections, Intravenous; Insecticides; Male; Naloxone; Prazosin; Tolazoline; Toluidines; Yohimbine | 1990 |
Serotonergic mediation of spinal analgesia and its interaction with noradrenergic systems.
Topics: Anesthesia, Spinal; Animals; Cats; Female; Injections, Intravenous; Injections, Spinal; Male; Methysergide; Naloxone; Neurons; Pain; Serotonin; Serotonin Antagonists; Yohimbine | 1990 |
Substance P-induced long-term blockade of spinal adrenergic analgesia: reversal by morphine and naloxone.
Topics: Analgesia; Animals; Clonidine; Kinetics; Male; Morphine; Naloxone; Norepinephrine; Pain; Rats; Rats, Inbred Strains; Spinal Cord; Substance P; Time Factors; Yohimbine | 1987 |
Pilocarpine-induced reciprocal hindlimb scratching in mice.
Topics: Animals; Cerebral Ventricles; Injections, Intraventricular; Male; Methysergide; Mice; Naloxone; Neurokinin B; Neuropeptides; Peptide Fragments; Phentolamine; Pilocarpine; Stereotyped Behavior; Substance P; Yohimbine | 1987 |
Noradrenergic and opioidergic influences on the antinociceptive effect of clomipramine in the formalin test in rats.
Topics: Analgesics; Animals; Clomipramine; Endorphins; Female; Formaldehyde; Morphine; Naloxone; Norepinephrine; Pain Measurement; Phentolamine; Prazosin; Rats; Rats, Inbred Strains; Yohimbine | 1989 |
Differential mechanisms mediating beta-endorphin- and morphine-induced analgesia in mice.
Topics: Analgesia; Animals; beta-Endorphin; Injections, Intraventricular; Injections, Spinal; Male; Methysergide; Mice; Mice, Inbred ICR; Morphine; Naloxone; Reaction Time; Yohimbine | 1989 |
Inhibition of vagal transmission by cardiac sympathetic nerve stimulation in the dog: possible involvement of opioid receptor.
Topics: Blood Pressure; Electric Stimulation; Enkephalin, Leucine; Heart; Heart Rate; Methacholine Chloride; Methacholine Compounds; Naloxone; Naltrexone; Norepinephrine; Prazosin; Receptors, Opioid; Sympathetic Nervous System; Synaptic Transmission; Vagus Nerve; Yohimbine | 1989 |
Differential actions of the blockade of spinal opioid, adrenergic and serotonergic receptors on the tail-flick inhibition induced by morphine microinjected into dorsal raphe and central gray in rats.
Topics: Animals; Dose-Response Relationship, Drug; Injections, Spinal; Male; Mesencephalon; Methysergide; Morphine; Naloxone; Pain; Raphe Nuclei; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Receptors, Opioid; Receptors, Serotonin; Spinal Cord; Yohimbine | 1989 |
Intrathecal bradykinin acts presynaptically on spinal noradrenergic terminals to produce antinociception in the rat.
Topics: Adrenergic alpha-Antagonists; Analgesics; Animals; Biogenic Monoamines; Bradykinin; Catecholamines; Catheters, Indwelling; Dioxanes; Endorphins; Hydroxydopamines; Idazoxan; Injections, Spinal; Kallidin; Male; Naloxone; Oxidopamine; Phentolamine; Prazosin; Propranolol; Rats; Rats, Inbred Strains; Reaction Time; Spinal Cord; Yohimbine | 1989 |
Putative mechanisms involved in excitatory and inhibitory effects of somatostatin on intestinal motility.
Topics: Acetylcholine; Animals; Bicuculline; Electric Stimulation; Female; gamma-Aminobutyric Acid; Gastrointestinal Motility; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Naloxone; Somatostatin; Theophylline; Yohimbine | 1989 |
Influence of dopaminergic and noradrenergic systems on the release of opioid peptides in guinea-pig ileum.
Topics: Adrenergic alpha-Antagonists; Animals; Domperidone; Dopamine; Endorphins; Female; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle, Smooth; Myenteric Plexus; Naloxone; Norepinephrine; Piperidines; Prazosin; Receptors, Dopamine; Yohimbine | 1989 |
Effect of berberine on myoelectric activity and transit of the small intestine in rats.
Topics: Administration, Oral; Administration, Topical; Animals; Atropine; Berberine; Berberine Alkaloids; Electromyography; Gastrointestinal Transit; Injections, Intraperitoneal; Injections, Intravenous; Intestine, Small; Male; Muscle, Smooth; Naloxone; Rats; Rats, Inbred Strains; Yohimbine | 1989 |
Catecholaminergic and opioidergic mechanisms involved in the hypotensive response of pindolol.
Topics: Animals; Blood Pressure; Catecholamines; Endorphins; Female; Heart Rate; Male; Naloxone; Pindolol; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Yohimbine | 1989 |
Naloxone pretreatment blocks the hypotensive effects of atenolol in SHR and WKY rats.
Topics: Animals; Antihypertensive Agents; Atenolol; Blood Pressure; Heart Rate; Male; Naloxone; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Yohimbine | 1989 |
[Effects of clopheline on impulse activity of neurons in the midbrain and dorsal horn of the spinal cord].
Topics: Animals; Cats; Clonidine; Mesencephalon; Naloxone; Neurons; Nociceptors; Pain; Prazosin; Spinal Cord; Yohimbine | 1989 |
Effect of yohimbine on nociceptive threshold in normoglycemic and streptozotocin-treated hyperglycemic mice.
Topics: Animals; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Male; Mice; Naloxone; Pain; Reaction Time; Sensory Thresholds; Temperature; Yohimbine | 1989 |
Effect of intravenously-administered putative and potential antagonists of ethanol on sleep time in ethanol-narcotized mice.
Topics: 4-Aminopyridine; Alcoholic Intoxication; Aminophylline; Aminopyridines; Amphetamine; Animals; Azides; Benzodiazepines; Dextroamphetamine; Doxapram; Ethanol; Male; Mice; Naloxone; Physostigmine; Propranolol; Sleep; Thyrotropin-Releasing Hormone; Yohimbine | 1988 |
Differential effects of yohimbine and naloxone on copulatory behaviors of male rats.
Topics: Animals; Arousal; Association Learning; Brain; Chlorides; Conditioning, Classical; Copulation; Ejaculation; Lithium; Lithium Chloride; Male; Motivation; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid; Yohimbine | 1988 |
Opioid-noradrenergic interactions in the neurohypophysis. II. Does noradrenaline mediate the actions of endogenous opioids on oxytocin and vasopressin release?
Topics: Animals; Arginine Vasopressin; Clonidine; Electric Stimulation; Endorphins; In Vitro Techniques; Isoproterenol; Male; Naloxone; Norepinephrine; Oxytocin; Pituitary Gland, Posterior; Rats; Receptors, Opioid; Yohimbine | 1988 |
Apparent pA2 estimates for an antinociceptive receptor.
Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Dose-Response Relationship, Drug; Drug Interactions; Female; Male; Mice; Morphine; Naloxone; Nociceptors; Reaction Time; Receptors, Adrenergic, alpha; Yohimbine | 1985 |
Characterization of inhibition of the spinal nociceptive tail-flick reflex in the rat from the medullary lateral reticular nucleus.
Topics: Animals; Atropine; Blood Pressure; Electric Stimulation; Glutamates; Glutamic Acid; Haloperidol; Injections, Spinal; Male; Methysergide; Microinjections; Naloxone; Nociceptors; Phentolamine; Prazosin; Rats; Rats, Inbred Strains; Reflex; Reticular Formation; Spinal Cord; Yohimbine | 1986 |
Effects of morphine and clonidine on sulphobromophthalein disposition in mice.
Topics: Animals; Bile; Clonidine; Liver; Male; Mice; Morphine; Naloxone; Sulfobromophthalein; Yohimbine | 1986 |
Spinal monoaminergic receptors mediate the antinociception produced by glutamate in the medullary lateral reticular nucleus.
Topics: Animals; Electric Stimulation; Glutamates; Glutamic Acid; Hot Temperature; Male; Methysergide; Microinjections; Naloxone; Nociceptors; Pain; Phentolamine; Prazosin; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Serotonin; Reticular Formation; Yohimbine | 1987 |
Antagonistic effects of alpha-adrenoceptor blocking agents on reticuloruminal hypomotility induced by xylazine in cattle.
Topics: Adrenergic alpha-Antagonists; Animals; Cattle; Domperidone; Female; Gastrointestinal Motility; Naloxone; Prazosin; Reticulum; Rumen; Thiazines; Tolazoline; Xylazine; Yohimbine | 1988 |
Combined opiate/adrenergic receptor blockade enhances squirrel monkey vocalization.
Topics: Adrenergic alpha-Antagonists; Animals; Drug Synergism; Male; Motor Activity; Naloxone; Receptors, Opioid; Saimiri; Social Isolation; Vocalization, Animal; Yohimbine | 1988 |
Physiological response of gray wolves to butorphanol-xylazine immobilization and antagonism by naloxone and yohimbine.
Topics: Animals; Atropine; Blood Pressure; Butorphanol; Carnivora; Drug Combinations; Female; Heart Rate; Immobilization; Male; Morphinans; Naloxone; Respiration; Thiazines; Xylazine; Yohimbine | 1989 |
Effects of dapiprazole, clonidine and yohimbine on the development of dependence and withdrawal behaviour in mice.
Topics: Animals; Behavior, Animal; Brain; Clonidine; Dose-Response Relationship, Drug; Injections, Intraventricular; Male; Mice; Mice, Inbred Strains; Morphine Dependence; Naloxone; Piperazines; Substance Withdrawal Syndrome; Triazoles; Yohimbine | 1989 |
Hypoinsulinemic and hyperglycemic effects of beta-endorphin in rabbits.
Topics: Animals; Atropine; beta-Endorphin; Blood Glucose; Endorphins; Female; Glucagon; Hyperglycemia; Injections, Intravenous; Insulin; Naloxone; Phentolamine; Propranolol; Quaternary Ammonium Compounds; Rabbits; Yohimbine | 1986 |
Pharmacological manipulation of sexual behaviour in stallions.
Topics: Animals; Clomipramine; Diazepam; Ejaculation; Fenclonine; Horses; Imipramine; Male; Naloxone; Penile Erection; Pituitary Hormone-Releasing Hormones; Sexual Behavior, Animal; Yohimbine | 1987 |
The localization of adrenoceptors and opiate receptors in regions of the cat central nervous system involved in cardiovascular control.
Topics: Animals; Cardiovascular System; Cats; Dihydromorphine; Female; Male; Medulla Oblongata; Naloxone; Olfactory Bulb; Prazosin; Receptors, Adrenergic; Receptors, Opioid; Spinal Cord; Yohimbine | 1985 |
Potentiation by TRH of the effect of imipramine on the forced-swimming test.
Topics: Animals; Drug Synergism; Drug Tolerance; Imipramine; Male; Mice; Morphine; Naloxone; Phenoxybenzamine; Phentolamine; Prazosin; Receptors, Adrenergic, alpha; Receptors, Opioid; Swimming; Thyrotropin-Releasing Hormone; Yohimbine | 1985 |
Methylnalorphinium fails to reverse naloxone-sensitive stress-induced analgesia in mice.
Topics: Analgesia; Animals; Cold Temperature; Endorphins; Male; Mice; Nalorphine; Naloxone; Nervous System; Pain; Restraint, Physical; Stress, Physiological; Synaptic Transmission; Yohimbine | 1986 |
Prompt arousal from fentanyl-droperidol-pentobarbital anesthesia in dogs: a preliminary study.
Topics: 4-Aminopyridine; Aminopyridines; Anesthesia; Anesthetics; Animals; Arousal; Dogs; Doxapram; Droperidol; Drug Combinations; Fentanyl; Naloxone; Pentobarbital; Yohimbine | 1986 |
Mutual interaction between presynaptic alpha 2-adrenoceptors and opioid kappa-receptors at the noradrenergic axons of rabbit brain cortex.
Topics: Animals; Axons; Cerebral Cortex; Clonidine; Cyclazocine; Ethylketocyclazocine; Female; Male; Naloxone; Norepinephrine; Rabbits; Receptors, Adrenergic, alpha; Receptors, Opioid; Yohimbine | 1986 |
On the relationship between clonidine hypotension and brain beta-endorphin in the spontaneously hypertensive rat: studies with alpha adrenergic and opiate blockers.
Topics: Animals; beta-Endorphin; Blood Pressure; Brain; Clonidine; Endorphins; Heart Rate; Hypertension; Hypothalamus; Male; Naloxone; Prazosin; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Adrenergic, alpha; Receptors, Opioid; Yohimbine | 1987 |
Alpha 2-adrenoceptor modulation of nociception in rat spinal cord: location, effects and interactions with morphine.
Topics: Animals; Autoradiography; Clonidine; Dihydromorphine; Drug Interactions; Electrophysiology; In Vitro Techniques; Injections, Spinal; Male; Morphine; Naloxone; Neurons; Nociceptors; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Spinal Cord; Yohimbine | 1987 |
Peripheral analgesic action of clonidine: mediation by release of endogenous enkephalin-like substances.
Topics: Analgesics; Animals; Carrageenan; Clonidine; Dinoprostone; Drug Tolerance; Enkephalins; Male; Morphine; Naloxone; Peripheral Nerves; Prostaglandins E; Rats; Rats, Inbred Strains; Yohimbine | 1988 |
Intrathecal morphine and clonidine: antinociceptive tolerance and cross-tolerance and effects on blood pressure.
Topics: Animals; Blood Pressure; Clonidine; Drug Administration Schedule; Drug Tolerance; Injections, Spinal; Male; Morphine; Naloxone; Pain; Rats; Rats, Inbred Strains; Reference Values; Spinal Cord; Yohimbine | 1988 |
Arylformamidines with antinociceptive properties.
Topics: Analgesia; Animals; Blood Pressure; Chemical Phenomena; Chemistry; Female; Male; Mice; Naloxone; Pain Measurement; Rats; Structure-Activity Relationship; Yohimbine | 1988 |
Potentiation of clonidine analgesia by amitriptyline.
Topics: Amitriptyline; Analgesia; Animals; Clonidine; Drug Synergism; Male; Mice; Naloxone; Yohimbine | 1986 |
Analgesic effect of metoclopramide and its mechanism.
Topics: Analgesics; Animals; Bromocriptine; Dose-Response Relationship, Drug; Male; Metoclopramide; Mice; Naloxone; Prolactin; Yohimbine | 1986 |
Biochemical correlates of morphine withdrawal. 2. Effects of clonidine.
Topics: Adrenal Glands; Animals; Clonidine; Denervation; Dose-Response Relationship, Drug; Epinephrine; Humans; Male; Morphine; Naloxone; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome; Yohimbine | 1985 |
Alphamethyldopa analgesia: its possible mechanism of action.
Topics: Analgesics; Animals; Male; Methyldopa; Mice; Naloxone; Pain; Physostigmine; Reaction Time; Time Factors; Yohimbine | 1985 |
Immobilization of free-ranging desert bighorn sheep, tule elk, and wild horses, using carfentanil and xylazine: reversal with naloxone, diprenorphine, and yohimbine.
Topics: Anesthesia, General; Animal Population Groups; Animals; Animals, Wild; Arousal; Deer; Desert Climate; Diprenorphine; Horses; Immobilization; Morphinans; Naloxone; Sheep; Thiazines; Xylazine; Yohimbine | 1985 |
The analgesic activity of a clonidine analog. The formamidine, U-47,476A.
Topics: Amidines; Analgesics; Animals; Antihypertensive Agents; Blood Pressure; Clonidine; Hypnotics and Sedatives; Mice; Motor Activity; Naloxone; Phentolamine; Rats; Rats, Inbred Strains; Reaction Time; Reserpine; Species Specificity; Time Factors; Yohimbine | 1985 |
A comparison of the cardiovascular and sedative actions of the alpha-adrenoceptor agonists, FLA-136 and clonidine, in the rat.
Topics: Adrenergic alpha-Agonists; Animals; Blood Pressure; Clonidine; Drug Interactions; Heart Rate; Hemodynamics; Hydroxydopamines; Hypnotics and Sedatives; Injections, Intraventricular; Male; Methohexital; Naloxone; Oxidopamine; Rats; Rats, Inbred Strains; Triazoles; Yohimbine | 1982 |
Reversal of the neuroleptanalgesic effect of droperidolfentanyl in the dog by 4-aminopyridine and naloxone.
Topics: 4-Aminopyridine; Aminopyridines; Animals; Blood Pressure; Cardiovascular Agents; Central Nervous System Stimulants; Dogs; Droperidol; Drug Combinations; Drug Therapy, Combination; Female; Fentanyl; Heart Rate; Male; Naloxone; Respiration; Yohimbine | 1982 |
Yohimbine antagonism of the inhibitory effects of pethidine and profadol in the mouse isolated vas deferens.
Topics: Animals; Drug Interactions; Male; Meperidine; Mice; Naloxone; Pyrrolidines; Vas Deferens; Yohimbine | 1983 |
Stress analgesia: effects of PCPA, yohimbine, and naloxone.
Topics: Analgesia; Animals; Electroshock; Fenclonine; Humans; Male; Naloxone; Neurotransmitter Agents; Rats; Rats, Inbred Strains; Reaction Time; Stress, Psychological; Yohimbine | 1984 |
Comparison of five preanesthetic medicaments in thiopental-anesthetized cats: antagonism by selected compounds.
Topics: 4-Aminopyridine; Acepromazine; Aminopyridines; Anesthesia, General; Animals; Arousal; Benzodiazepinones; Cats; Central Nervous System Stimulants; Convulsants; Diazepam; Drug Antagonism; Female; Flumazenil; Ketamine; Male; Meperidine; Naloxone; Pentobarbital; Preanesthetic Medication; Sodium Chloride; Xylazine; Yohimbine | 1984 |
Possible role of an endogenous opiate in the cardiovascular effects of central alpha adrenoceptor stimulation in spontaneously hypertensive rats.
Topics: Anesthesia; Animals; Blood Pressure; Clonidine; Dose-Response Relationship, Drug; Drug Interactions; Endorphins; Heart Rate; Hypertension; Male; Methyldopa; Morphine; Naloxone; Naltrexone; Rats; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Receptors, Opioid; Time Factors; Yohimbine | 1980 |
Antinociceptive actions of clonidine.
Topics: Animals; Brain; Clonidine; Dose-Response Relationship, Drug; Drug Tolerance; Male; Morphine; Muridae; Naloxone; Nociceptors; Phenoxybenzamine; Premedication; Receptors, Adrenergic; Receptors, Opioid; Spinal Cord; Yohimbine | 1981 |
[Central alpha-adrenergic receptors are involved in the physiological regulation of exocrine pancreatic secretion; opiate receptors may not be].
Topics: Animals; Brain; Guinea Pigs; Naloxone; Pancreas; Rats; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Receptors, Opioid; Yohimbine | 1982 |
Involvement of both opiate and catecholaminergic receptors in the behavioural excitation provoked by thyrotropin-releasing hormone: comparisons with amphetamine.
Topics: Amphetamine; Animals; Behavior, Animal; Haloperidol; Humans; Hyperkinesis; Male; Naloxone; Propranolol; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Receptors, Opioid; Receptors, Serotonin; Thyrotropin-Releasing Hormone; Yohimbine | 1983 |
Antinociceptive studies of the optical isomers of N-allylnormetazocine (SKF 10,047).
Topics: Analgesics; Animals; Male; Mice; Mice, Inbred ICR; Morphine; Naloxone; Phenazocine; Receptors, Adrenergic, alpha; Receptors, Opioid; Stereoisomerism; Yohimbine | 1983 |
Monoaminergic antagonists which block naloxone-induced release of luteinizing hormone bind selectively to hypothalamic opiate receptors.
Topics: Animals; Dose-Response Relationship, Drug; Female; Hypothalamus; Luteinizing Hormone; Naloxone; Phentolamine; Prazosin; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Receptors, Opioid; Sympatholytics; Yohimbine | 1983 |
Antinociceptive activity of N-(4-hydroxyphenacetyl)-4-aminoclonidine, a novel analog of clonidine: role of opioid receptors and alpha-adrenoceptors.
Topics: Analgesics; Animals; Aorta, Thoracic; Benzeneacetamides; Clonidine; Dose-Response Relationship, Drug; Drug Antagonism; Kinetics; Male; Mice; Morphine; Naloxone; Receptors, Adrenergic, alpha; Receptors, Opioid; Xylazine; Yohimbine | 1983 |
Chronic naltrexone increases opiate binding in brain and produces supersensitivity to morphine in the locus coeruleus of the rat.
Topics: Animals; Brain; Etorphine; Locus Coeruleus; Male; Morphine; Naloxone; Naltrexone; Narcotics; Neurons; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Synaptic Transmission; Yohimbine | 1983 |
Modification of receptor-mediated inhibition of adenylate cyclase in NG108-15 neuroblastoma X glioma cells by n-ethylmaleimide.
Topics: Adenylyl Cyclase Inhibitors; Animals; Cell Line; Epinephrine; Ethylmaleimide; Glioma; GTP-Binding Proteins; Morphine; Naloxone; Neuroblastoma; Oxotremorine; Quinuclidinyl Benzilate; Receptors, Adrenergic, alpha; Receptors, Cell Surface; Receptors, Cholinergic; Receptors, Muscarinic; Receptors, Neurotransmitter; Receptors, Opioid; Yohimbine | 1984 |
Both dopaminergic and adrenergic receptors in the brain are involved in the behavioural excitation induced by dibutyryl 3',5'-adenosine monophosphate and aminophylline in the rat.
Topics: Aminophylline; Animals; Behavior, Animal; Brain; Bucladesine; Haloperidol; Injections, Intraventricular; Male; Naloxone; Phentolamine; Propranolol; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Receptors, Dopamine; Yohimbine | 1984 |
Drinking: a final common pathway?
Topics: Angiotensin II; Animals; Clonidine; Drinking Behavior; Drug Combinations; Female; Isoproterenol; Male; Naloxone; Rats; Rats, Inbred Strains; Yohimbine | 1984 |
Changes in clonidine effect on longitudinal muscle-myenteric plexus strip preparation by morphine treatments.
Topics: Animals; Clonidine; Guinea Pigs; Morphine; Muscle, Smooth; Myenteric Plexus; Naloxone; Prazosin; Yohimbine | 1983 |
Comparison of five preanesthetic medicaments in pentobarbital-anesthetized dogs: antagonism by 4-aminopyridine, yohimbine, and naloxone.
Topics: 4-Aminopyridine; Aminopyridines; Anesthesia, General; Animals; Dogs; Drug Combinations; Female; Heart Rate; Male; Naloxone; Neuromuscular Depolarizing Agents; Pentobarbital; Preanesthetic Medication; Respiration; Yohimbine | 1983 |
Yohimbine exacerbates and clonidine attenuates acute morphine withdrawal in rats.
Topics: Animals; Behavior, Animal; Clonidine; Drug Interactions; Humans; Male; Morphine; Naloxone; Rats; Rats, Inbred Strains; Reinforcement Schedule; Substance Withdrawal Syndrome; Yohimbine | 1983 |
Effects of clonidine and xylazine on body temperature in the rat.
Topics: Animals; Body Temperature; Clonidine; Dose-Response Relationship, Drug; Drug Interactions; Male; Naloxone; Rats; Rats, Inbred Strains; Temperature; Thiazines; Time Factors; Xylazine; Yohimbine | 1984 |
Subplantar yeast injection induces a non-naloxone reversible antinociception in spontaneously hypertensive rats.
Topics: Animals; Endorphins; Hypertension; Male; Naloxone; Norepinephrine; Pain; Rats; Rats, Inbred Strains; Reaction Time; Yeast, Dried; Yohimbine | 1984 |
Effects of the training dose on generalization of morphine stimulus to clonidine.
Topics: Animals; Clonidine; Conditioning, Operant; Discrimination Learning; Generalization, Stimulus; Male; Morphine; Naloxone; Rats; Rats, Inbred Strains; Yohimbine | 1984 |
An analysis of the effects of systemically administered clonidine on the food and water intake of rats.
Topics: Animals; Clonidine; Drinking; Drug Interactions; Eating; Male; Morphine; Naloxone; Rats; Rats, Inbred Strains; Time Factors; Yohimbine | 1983 |
Effects of yohimbine and naltrexone in counteraction of the morphine Straub tail and the amphetamine-potentiated morphine Straub tail in mice.
Topics: Amphetamine; Animals; Male; Mice; Morphine; Naloxone; Naltrexone; Phentolamine; Tail; Yohimbine | 1982 |
Morphine-like effects of clonidine on the EEG, slow wave sleep and behavior in the dog.
Topics: Animals; Autonomic Nervous System; Behavior, Animal; Clonidine; Dogs; Electroencephalography; Injections, Intravenous; Injections, Intraventricular; Male; Morphine; Naloxone; Sleep; Yohimbine | 1982 |
Pain modulation by adrenergic agents and morphine as measured by three pain tests.
Topics: Animals; Drug Interactions; Male; Methods; Morphine; Naloxone; Pain; Rats; Reaction Time; Sympathomimetics; Time Factors; Yohimbine | 1980 |
Behavioural profile of two potential antidepressant pyridazine derivatives including arylpiperazinyl moieties in their structure, in mice.
Topics: 5-Hydroxytryptophan; Analgesia; Animals; Antidepressive Agents; Apomorphine; Behavior, Animal; Blepharoptosis; Citalopram; Clomipramine; Drug Interactions; Fluoxetine; Hypothermia; Imipramine; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Mice; Models, Molecular; Motor Activity; Naloxone; Piperazines; Pyridazines; Reserpine; Structure-Activity Relationship; Swimming; Trazodone; Yohimbine | 1995 |
The role of alpha-adrenergic mechanisms within the area postrema in dopamine-induced emesis.
Topics: Adrenergic alpha-Antagonists; alpha-Methyltyrosine; Animals; Atropine; Cats; Cerebral Ventricles; Dioxanes; Disease Models, Animal; Dopamine; Dopamine Antagonists; Dose-Response Relationship, Drug; Female; Hemicholinium 3; Idazoxan; Injections, Intraventricular; Male; Mecamylamine; Methyltyrosines; Methysergide; Naloxone; Oxidopamine; Prazosin; Reserpine; Tolazoline; Tyrosine 3-Monooxygenase; Vomiting; Yohimbine | 1995 |
Effects induced by cysteamine on chemically-induced nociception in mice.
Topics: Amino Acid Sequence; Animals; Cysteamine; Drug Interactions; Locomotion; Male; Mice; Molecular Sequence Data; Naloxone; Organophosphorus Compounds; Pain; Somatostatin; Yohimbine | 1994 |
Clonidine has comparable effects on spontaneous sympathetic activity and afferent A delta and C-fiber-mediated somatosympathetic reflexes in dogs.
Topics: Animals; Blood Pressure; Clonidine; Dogs; Electric Stimulation; Heart Rate; Infusions, Intravenous; Injections, Intravenous; Injections, Spinal; Kidney; Naloxone; Nerve Fibers; Nerve Fibers, Myelinated; Neurons, Afferent; Reflex; Sympathetic Nervous System; Yohimbine | 1994 |
Atrial natriuretic peptide inhibits the purinergic and not the adrenergic component of electrically induced contractile responses in guinea pig vas deferens.
Topics: Adenosine Triphosphate; Adrenergic Antagonists; Animals; Atrial Natriuretic Factor; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Indomethacin; Male; Muscle Contraction; Naloxone; Neurotransmitter Agents; Nitrendipine; Phenylephrine; Prazosin; Receptors, Adrenergic; Receptors, Purinergic; Vas Deferens; Verapamil; Yohimbine | 1993 |
Involvement of alpha 2-receptors in the analgesia induced by transient forebrain ischemia in rats.
Topics: Adrenergic alpha-Antagonists; Analgesia; Animals; Brain; Carotid Artery, Common; Clonidine; Dioxanes; Endorphins; Idazoxan; Ischemic Attack, Transient; Male; Methysergide; Naloxone; Norepinephrine; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha; Serotonin; Synaptic Transmission; Yohimbine | 1993 |
Effects of the central analgesic tramadol and its main metabolite, O-desmethyltramadol, on rat locus coeruleus neurones.
Topics: Action Potentials; Animals; Extracellular Space; In Vitro Techniques; Locus Coeruleus; Male; Membrane Potentials; Naloxone; Neurons; Norepinephrine; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Receptors, Opioid, mu; Stereoisomerism; Tramadol; Yohimbine | 1993 |
Comparison of the effects of T-1815, yohimbine and naloxone on mouse colonic propulsion.
Topics: Administration, Oral; Animals; Clonidine; Colon; Dose-Response Relationship, Drug; Gastrointestinal Motility; Loperamide; Male; Mice; Naloxone; Propylamines; Thiophenes; Yohimbine | 1993 |
Analgesic effect of morphine, clonidine and serotonin microinjected into the PTN of rats.
Topics: Analgesics; Animals; Clonidine; Male; Methysergide; Microinjections; Morphine; Naloxone; Pain Measurement; Rats; Serotonin; Superior Colliculi; Yohimbine | 1993 |
Naloxone potentiation of novelty-induced hypoalgesia: characterization of the alpha-noradrenergic receptor subtype.
Topics: Animals; Clonidine; Drug Synergism; Habituation, Psychophysiologic; Male; Naloxone; Pain; Phentolamine; Prazosin; Rats; Rats, Wistar; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Yohimbine | 1993 |
Effects of the central analgesic tramadol on the uptake and release of noradrenaline and dopamine in vitro.
Topics: 5-Hydroxytryptophan; Animals; Caudate Nucleus; Chinchilla; Cocaine; Dopamine; Female; In Vitro Techniques; Male; Morphine; Naloxone; Norepinephrine; Rabbits; Rats; Rats, Sprague-Dawley; Stereoisomerism; Synaptosomes; Tramadol; Yohimbine | 1993 |
Participation of the central noradrenergic system in the reestablishment of copulatory behavior of sexually exhausted rats by yohimbine, naloxone, and 8-OH-DPAT.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Benzylamines; Central Nervous System; Copulation; Ejaculation; Male; Motivation; Motor Activity; Naloxone; Narcotic Antagonists; Neurotoxins; Norepinephrine; Rats; Rats, Wistar; Satiety Response; Serotonin Receptor Agonists; Sympathetic Nervous System; Sympatholytics; Yohimbine | 1995 |
Antinociceptive effect of smilaxin B administered intracerebroventricularly in the mouse.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Baclofen; Cerebral Ventricles; Dizocilpine Maleate; Glycosides; Injections, Intraventricular; Injections, Spinal; Male; Methysergide; Mice; Mice, Inbred ICR; Muscimol; Naloxone; Pain; Sincalide; Spinal Cord; Spirostans; Yohimbine | 1996 |
[Clinical investigations of an i.m. combination anesthesia with fentanylclimazolam/xylazine and postoperative i.v. antagonism with naloxone/sarmazenil/yohimbine in guinea pigs].
Topics: Anesthesia, General; Anesthetics, Intravenous; Animals; Anti-Anxiety Agents; Benzodiazepines; Drug Combinations; Female; Fentanyl; Guinea Pigs; Imidazoles; Injections, Intramuscular; Injections, Intravenous; Male; Midazolam; Naloxone; Narcotic Antagonists; Xylazine; Yohimbine | 1996 |
Spinal cholinergic and monoamine receptors mediate the antinociceptive effect of morphine microinjected in the periaqueductal gray on the rat tail, but not the feet.
Topics: Animals; Atropine; Biogenic Monoamines; Female; Foot; Injections, Spinal; Methysergide; Microinjections; Morphine; Naloxone; Nociceptors; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Receptors, Cholinergic; Spinal Cord; Tail; Yohimbine | 1996 |
Intrathecal Tyr-W-MIF-1 produces potent, naloxone-reversible analgesia modulated by alpha 2-adrenoceptors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Amino Acid Sequence; Animals; Desipramine; Dose-Response Relationship, Drug; Injections, Spinal; Male; Mice; Molecular Sequence Data; MSH Release-Inhibiting Hormone; Naloxone; Naltrexone; Narcotic Antagonists; Norepinephrine; Receptors, Adrenergic, alpha-2; Yohimbine | 1996 |
Antinociceptive response to nitrous oxide is mediated by supraspinal opiate and spinal alpha 2 adrenergic receptors in the rat.
Topics: Adrenergic alpha-Antagonists; Analgesics; Analgesics, Non-Narcotic; Animals; Imidazoles; Male; Naloxone; Narcotic Antagonists; Nitrous Oxide; Nociceptors; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, Opioid; Spinal Cord; Yohimbine | 1996 |
alpha-Adrenoceptor and opioid receptor modulation of clonidine-induced antinociception.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Behavior, Animal; Clonidine; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Injections, Intraventricular; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement; Prazosin; Receptors, Opioid; Yohimbine | 1996 |
Multiple receptors involved in peripheral alpha 2, mu, and A1 antinociception, tolerance, and withdrawal.
Topics: Adenosine; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analgesics; Analgesics, Opioid; Animals; Clonidine; Dinoprostone; Drug Interactions; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Hyperalgesia; Male; Models, Biological; Naloxone; Narcotic Antagonists; Oligonucleotides, Antisense; Purinergic P1 Receptor Agonists; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, Opioid, mu; Receptors, Purinergic P1; Second Messenger Systems; Substance Withdrawal Syndrome; Substance-Related Disorders; Xanthines; Yohimbine | 1997 |
Effects of phentolamine or yohimbine on naloxone's actions during endotoxin shock in rats.
Topics: Adrenergic alpha-Antagonists; Animals; Blood Flow Velocity; Blood Pressure; Cardiac Output; Endotoxins; Hemodynamics; Hypotension; Male; Naloxone; Narcotic Antagonists; Phentolamine; Rats; Rats, Sprague-Dawley; Shock, Septic; Vascular Resistance; Vasoconstriction; Yohimbine | 1997 |
Modulation of neurotransmitter release by opioid mu- and kappa-receptors from adrenergic terminals in the myenteric plexus of the guinea-pig colon: effect of alpha 2-autoreceptor blockade.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analgesics; Animals; Colon; Dose-Response Relationship, Drug; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guinea Pigs; Myenteric Plexus; Naloxone; Naltrexone; Narcotic Antagonists; Neurotransmitter Agents; Norepinephrine; Pyrrolidines; Receptors, Adrenergic, alpha-2; Receptors, Opioid, kappa; Receptors, Opioid, mu; Yohimbine | 1997 |
Differential effects of clonidine and dexmedetomidine on gastric emptying and gastrointestinal transit in the rat.
Topics: Adrenergic alpha-Agonists; Analgesics, Opioid; Animals; Clonidine; Dose-Response Relationship, Drug; Gastric Emptying; Gastrointestinal Transit; Imidazoles; Male; Medetomidine; Morphine; Naloxone; Rats; Rats, Wistar; Yohimbine | 1997 |
Clonidine inhibits gastric motility in the rat.
Topics: Adjuvants, Anesthesia; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Clonidine; Gastric Emptying; Male; Naloxone; Rats; Rats, Wistar; Yohimbine | 1997 |
Stimulatory effect of intracerebroventricular met- and leu-enkephalin on corticosterone secretion in rats.
Topics: Adrenergic alpha-Antagonists; Animals; Cerebral Ventricles; Corticosterone; Enkephalin, Leucine; Enkephalin, Methionine; Hypothalamus; Injections, Intraventricular; Male; Naloxone; Narcotic Antagonists; Pituitary-Adrenal System; Rats; Rats, Wistar; Receptors, Adrenergic; Yohimbine | 1996 |
A comparative study of the antinociceptive action of xenon and nitrous oxide in rats.
Topics: Analgesics, Non-Narcotic; Animals; Male; Naloxone; Nitrous Oxide; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Xenon; Yohimbine | 1997 |
Opiate receptors in the periaqueductal gray mediate analgesic effect of nitrous oxide in rats.
Topics: Adrenergic alpha-Antagonists; Analgesics, Non-Narcotic; Animals; Injections, Intraventricular; Male; Microinjections; Naloxone; Narcotic Antagonists; Nitrous Oxide; Pain Threshold; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Yohimbine | 1997 |
Evidence for a role for bulbospinal pathways in the spinal antinociceptive effect of systemically administered vapreotide in normal rats.
Topics: Adrenergic alpha-Antagonists; Analgesics; Animals; Hindlimb; Indoles; Injections, Spinal; Injections, Subcutaneous; Male; Naloxone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Serotonin Antagonists; Somatostatin; Spinal Cord; Tropisetron; Yohimbine | 1998 |
Effects of yohimbine on naloxone-induced antinociception in a rat model of inflammatory hyperalgesia.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Carrageenan; Hyperalgesia; Inflammation; Injections, Intraperitoneal; Male; Naloxone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Yohimbine | 1998 |
The antinociceptive effect of moclobemide in mice is mediated by noradrenergic pathways.
Topics: Analgesics; Animals; Benzamides; Clonidine; Dose-Response Relationship, Drug; Drug Administration Schedule; Injections, Intraperitoneal; Injections, Spinal; Injections, Subcutaneous; Male; Metergoline; Mice; Mice, Inbred ICR; Moclobemide; Monoamine Oxidase Inhibitors; Morphine; Naloxone; Neural Pathways; Norepinephrine; Receptors, Adrenergic, alpha-2; Serotonin; Yohimbine | 1998 |
Interaction of the alpha-2 adrenergic- and opioid receptor with the cGMP system in the mouse cerebellum.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analgesics, Opioid; Analysis of Variance; Animals; Cerebellum; Cyclic GMP; Fentanyl; Imidazoles; Male; Medetomidine; Mice; Naloxone; Narcotic Antagonists; Receptors, Adrenergic, alpha-2; Receptors, Opioid; Yohimbine | 1998 |
Spirobutenolides substituted by arylpiperazinyl-carbonyl moieties. Synthesis and antinociceptive properties.
Topics: 5-Hydroxytryptophan; Adrenergic alpha-Antagonists; Analgesics; Analgesics, Opioid; Animals; Benzoquinones; Drug Synergism; Furans; Male; Mice; Morphine; Motor Activity; Naloxone; Narcotic Antagonists; Pain Measurement; Reaction Time; Spiro Compounds; Yohimbine | 1998 |
Quinine-induced inhibition of gastrointestinal transit in mice: possible involvement of endogenous opioids.
Topics: Adenosine Triphosphate; Adrenergic alpha-Antagonists; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Gastrointestinal Transit; Glyburide; Male; Mice; Minoxidil; Morphine; Naloxone; Narcotic Antagonists; Opioid Peptides; Potassium Channels; Quinine; Yohimbine | 1999 |
Corticosterone response induced by intracerebroventricular administration of met-enkephalin and naloxone in rats under stress.
Topics: Animals; Corticosterone; Dose-Response Relationship, Drug; Enkephalin, Methionine; Immobilization; Injections, Intraventricular; Male; Naloxone; Prazosin; Propranolol; Rats; Rats, Wistar; Receptors, Adrenergic; Receptors, Opioid; Stress, Physiological; Yohimbine | 1997 |
Effects of tramadol on minimum alveolar concentration (MAC) of isoflurane in rats.
Topics: Adrenergic alpha-Antagonists; Analgesics, Opioid; Anesthetics, Inhalation; Animals; Drug Interactions; Isoflurane; Male; Morphine; Naloxone; Narcotic Antagonists; Pulmonary Alveoli; Rats; Rats, Wistar; Tramadol; Yohimbine | 1999 |
Changes in catecholaminergic pathways innervating paraventricular nucleus and pituitary-adrenal axis response during morphine dependence: implication of alpha(1)- and alpha(2)-adrenoceptors.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Autonomic Pathways; Catecholamines; Corticosterone; Dopamine; Male; Morphine Dependence; Naloxone; Narcotic Antagonists; Norepinephrine; Paraventricular Hypothalamic Nucleus; Pituitary-Adrenal System; Prazosin; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Yohimbine | 2000 |
Synthesis and analgesic effects of 5-[4-(arylpiperazin-1-yl)alkylamino]-4-benzyl-3-methyl-1,2-oxa zin-6-one s.
Topics: 5-Hydroxytryptophan; Adrenergic alpha-Antagonists; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Behavior, Animal; Benzoquinones; Binding, Competitive; Brain Chemistry; Drug Synergism; Male; Mice; Morphine; Motor Activity; Naloxone; Narcotic Antagonists; Oxazines; Pain Measurement; Piperazines; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Yohimbine | 2000 |
Norepinephrine modulates single hypothalamic arcuate neurons via alpha(1)and beta adrenergic receptors.
Topics: Action Potentials; Animals; Arcuate Nucleus of Hypothalamus; Calcium; Cromakalim; Female; Glyburide; In Vitro Techniques; Locus Coeruleus; Magnesium; Male; Morphine; Naloxone; Neural Inhibition; Neural Pathways; Neurons; Norepinephrine; Phentolamine; Prazosin; Propranolol; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, beta; Yohimbine | 2000 |
Antinociception induced by amitriptyline and imipramine is mediated by alpha2A-adrenoceptors.
Topics: Amitriptyline; Analgesics, Non-Narcotic; Animals; Antidepressive Agents, Tricyclic; Dose-Response Relationship, Drug; Imidazoles; Imipramine; Indoles; Isoindoles; Male; Mice; Naloxone; Organophosphorus Compounds; Receptors, Adrenergic, alpha-2; Yohimbine | 2000 |
Neural circuits regulating pulsatile luteinizing hormone release in the female guinea-pig: opioid, adrenergic and serotonergic interactions.
Topics: Animals; Clonidine; Drug Interactions; Female; Fentanyl; Gonadotropin-Releasing Hormone; Guinea Pigs; Luteinizing Hormone; Methysergide; Naloxone; Norepinephrine; Opioid Peptides; Ovariectomy; Periodicity; Quipazine; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Yohimbine | 2001 |
Hyperglycaemia: a morphine-like effect produced by naloxone.
Topics: Adrenergic alpha-Antagonists; Animals; Blood Glucose; Dioxanes; Hyperglycemia; Male; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Rabbits; Receptors, Adrenergic, alpha-2; Yohimbine | 2001 |
Antinociceptive and respiratory effects of intrathecal H-Tyr-D-Arg-Phe-Lys-NH2 (DALDA) and [Dmt1] DALDA.
Topics: Analgesics; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Injections, Spinal; Male; Morphine; Naloxone; Norepinephrine; Oligopeptides; Rats; Rats, Sprague-Dawley; Respiration; Serotonin; Yohimbine | 2001 |
Effect of vanilloid drugs on gastrointestinal transit in mice.
Topics: Alkaloids; Animals; Arachidonic Acids; Benzodioxoles; Capsaicin; Dose-Response Relationship, Drug; Endocannabinoids; Gastrointestinal Transit; Hexamethonium; Male; Mice; Mice, Inbred ICR; Naloxone; NG-Nitroarginine Methyl Ester; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Drug; Rimonabant; Yohimbine | 2001 |
Visceral antinociception produced by bee venom stimulation of the Zhongwan acupuncture point in mice: role of alpha(2) adrenoceptors.
Topics: Acetic Acid; Acupuncture Analgesia; Adrenergic alpha-Antagonists; Analgesics; Animals; Bee Venoms; Dose-Response Relationship, Drug; Immunohistochemistry; Injections, Intraperitoneal; Male; Mice; Mice, Inbred ICR; Naloxone; Narcotic Antagonists; Neurons; Nociceptors; Peritoneum; Proto-Oncogene Proteins c-fos; Receptors, Adrenergic, alpha-2; Receptors, Opioid; Solitary Nucleus; Spinal Cord; Visceral Afferents; Yohimbine | 2001 |
Clonidine attenuates naloxone-induced opioid-withdrawal syndrome in cholestatic mice.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Cholestasis; Clonidine; Disease Models, Animal; Male; Mice; Naloxone; Narcotic Antagonists; Opioid Peptides; Substance Withdrawal Syndrome; Yohimbine | 2001 |
Inhibitory effect of palmitoylethanolamide on gastrointestinal motility in mice.
Topics: Adrenergic alpha-Antagonists; Amides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Camphanes; Croton Oil; Dose-Response Relationship, Drug; Endocannabinoids; Enzyme Inhibitors; Ethanolamines; Gastrointestinal Motility; Gastrointestinal Transit; Hexamethonium; Inflammation; Intestine, Small; Male; Mice; Mice, Inbred ICR; Naloxone; NG-Nitroarginine Methyl Ester; Nicotinic Antagonists; Nitric Oxide Synthase; Palmitic Acids; Phenylmethylsulfonyl Fluoride; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Yohimbine | 2001 |
The role of leucine-enkephalin on insulin and glucagon secretion from pancreatic tissue fragments of normal and diabetic rats.
Topics: Animals; Atropine; Diabetes Mellitus, Experimental; Enkephalin, Leucine; Glucagon; Insulin; Insulin Secretion; Naloxone; Pancreas; Rats; Yohimbine | 2001 |
The effects of simultaneous administration of alpha(2) -adrenergic agents with L-NAME or L-arginine on the development and expression of morphine dependence in mice.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Arginine; Clonidine; Enzyme Inhibitors; Male; Mice; Morphine Dependence; Naloxone; Narcotic Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Substance Withdrawal Syndrome; Yohimbine | 2002 |
Lithium inhibits the development of physical dependence to clonidine in mice.
Topics: Administration, Oral; Adrenergic alpha-Antagonists; Animals; Clonidine; Injections, Intraperitoneal; Lithium; Male; Mice; Morphine; Morphine Dependence; Naloxone; Narcotic Antagonists; Substance Withdrawal Syndrome; Substance-Related Disorders; Yohimbine | 2002 |
Noradrenaline release in rat locus coeruleus is regulated by both opioid and alpha(2) -adrenoceptors.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Behavior, Animal; Clonidine; Injections, Intraventricular; Locus Coeruleus; Male; Microdialysis; Morphine; Morphine Dependence; Naloxone; Narcotic Antagonists; Narcotics; Norepinephrine; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, Opioid; Substance Withdrawal Syndrome; Yohimbine | 2002 |
Antinociceptive mechanisms of platycodin D administered intracerebroventricularly in the mouse.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Analgesics; Animals; Baclofen; Carbohydrate Sequence; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; GABA Agonists; GABA Antagonists; Injections, Intraventricular; Injections, Spinal; Male; Methysergide; Mice; Mice, Inbred ICR; Molecular Sequence Data; Muscimol; Naloxone; Narcotic Antagonists; Pain Measurement; Plant Extracts; Platycodon; Receptors, Cholecystokinin; Receptors, N-Methyl-D-Aspartate; Saponins; Serotonin Antagonists; Sincalide; Tail; Triterpenes; Yohimbine | 2002 |
The contribution of alpha2-adrenoceptor and opioid receptor mechanisms to antinociception differs in Lewis and Fischer 344 rats.
Topics: Adrenergic alpha-Agonists; Analgesics, Opioid; Animals; Clonidine; Dose-Response Relationship, Drug; Female; Morphine; Naloxone; Pain Threshold; Rats; Rats, Inbred F344; Rats, Inbred Lew; Receptors, Adrenergic, alpha-2; Receptors, Opioid; Species Specificity; Time Factors; Yohimbine | 2003 |
Antinociceptive mechanisms of orally administered decursinol in the mouse.
Topics: Administration, Oral; Adrenergic alpha-Antagonists; Analgesics; Animals; Benzopyrans; Butyrates; Cyproheptadine; Dose-Response Relationship, Drug; Glutamic Acid; Histamine H2 Antagonists; Interferon-gamma; Interleukin-1; Male; Methysergide; Mice; Mice, Inbred ICR; Models, Chemical; Naloxone; Narcotic Antagonists; Pain; Piperidines; Protein Kinase C; Ranitidine; Receptors, Adrenergic; Receptors, Histamine; Receptors, Purinergic P1; Receptors, Serotonin; Serotonin Antagonists; Substance P; Theobromine; Tumor Necrosis Factor-alpha; Xanthines; Yohimbine | 2003 |
Imipramine-induced antinociception in the formalin test. Receptor mechanisms involved and effect of swim stress.
Topics: Animals; Dose-Response Relationship, Drug; Imipramine; Injections, Intraventricular; Male; Mice; Mice, Inbred Strains; Naloxone; Nociceptors; Pain; Pain Measurement; Prazosin; Stress, Physiological; Swimming; Yohimbine | 2003 |
Influence of histamine, cimetidine and pyrilamine on naloxone-induced jumping in morphine-dependent mice.
Topics: Animals; Atropine; Cimetidine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Combinations; Drug Interactions; Histamine; Histamine H2 Antagonists; Injections, Intraperitoneal; Injections, Intraventricular; Injections, Subcutaneous; Mice; Morphine; Morphine Dependence; Motor Activity; Naloxone; Prazosin; Propranolol; Pyrilamine; Receptors, Histamine H2; Yohimbine | 2003 |
Joint manipulation reduces hyperalgesia by activation of monoamine receptors but not opioid or GABA receptors in the spinal cord.
Topics: Adrenergic alpha-Antagonists; Animals; Bicuculline; GABA Antagonists; Hyperalgesia; Joints; Male; Methysergide; Naloxone; Narcotic Antagonists; Pain; Pain Management; Physical Stimulation; Physical Therapy Modalities; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic; Receptors, GABA; Receptors, Opioid; Receptors, Serotonin; Serotonin Antagonists; Spinal Cord; Yohimbine | 2003 |
Agmatine inhibits naloxone-induced contractions in morphine-dependent Guinea pig ileum.
Topics: Adrenergic alpha-Antagonists; Agmatine; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Guinea Pigs; Idazoxan; Ileum; Male; Morphine; Morphine Dependence; Muscle Contraction; Naloxone; Narcotic Antagonists; Substance Withdrawal Syndrome; Yohimbine | 2003 |
Inhibitory effect of harmane on morphine-dependent Guinea pig ileum.
Topics: Adrenergic alpha-Antagonists; Analgesics, Opioid; Animals; Guinea Pigs; Harmine; Idazoxan; Ileum; In Vitro Techniques; Male; Morphine; Morphine Dependence; Muscle Contraction; Naloxone; Narcotic Antagonists; Substance Withdrawal Syndrome; Yohimbine | 2003 |
Changes in c-fos expression in the rat heart during morphine withdrawal. Involvement of alpha2-adrenoceptors.
Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Blotting, Western; Body Weight; Drug Administration Schedule; Drug Therapy, Combination; Gene Expression; Genes, fos; Heart Ventricles; Immunohistochemistry; Injections, Subcutaneous; Male; Morphine; Myocytes, Cardiac; Naloxone; Normetanephrine; Prazosin; Propranolol; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Substance Withdrawal Syndrome; Time Factors; Yohimbine | 2004 |
Alpha2-adrenergic inhibition prevents the accompanied anticonvulsant effect of swim stress on behavioral convulsions induced by lithium and pilocarpine.
Topics: Adrenergic alpha-Antagonists; Animals; Anticonvulsants; Lithium; Male; Mifepristone; Naloxone; Pilocarpine; Rats; Rats, Wistar; Seizures; Stress, Physiological; Swimming; Yohimbine | 2004 |
Evidence that (-)-7-hydroxy-4'-dimethylheptyl-cannabidiol activates a non-CB(1), non-CB(2), non-TRPV1 target in the mouse vas deferens.
Topics: Adenosine Triphosphate; Adrenergic alpha-2 Receptor Antagonists; Animals; Benzoxazines; Cannabidiol; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Capsaicin; In Vitro Techniques; Isometric Contraction; Male; Mice; Morpholines; Naloxone; Naphthalenes; Phenylephrine; Piperidines; Pyrazoles; Rimonabant; Ruthenium Red; TRPV Cation Channels; Vas Deferens; Yohimbine | 2005 |
Characterisation of alpha2-adrenoceptor subtypes involved in gastric emptying, gastric motility and gastric mucosal defence.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Clonidine; Disease Models, Animal; Dose-Response Relationship, Drug; Ethanol; Gastric Emptying; Gastric Mucosa; Gastrointestinal Motility; Male; Muscle Contraction; Muscle, Smooth; Naloxone; Narcotic Antagonists; Oxymetazoline; Prazosin; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Stomach Ulcer; Yohimbine | 2005 |
Antinociceptive effect and the mechanism of bee venom acupuncture (Apipuncture) on inflammatory pain in the rat model of collagen-induced arthritis: Mediation by alpha2-Adrenoceptors.
Topics: Acupuncture Points; Adrenergic alpha-Antagonists; Animals; Arthritis, Experimental; Bee Venoms; Behavior, Animal; Collagen; Disease Models, Animal; Drug Administration Routes; Drug Interactions; Male; Naloxone; Narcotic Antagonists; Pain; Pain Management; Pain Measurement; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Adrenergic, alpha-2; Statistics, Nonparametric; Yohimbine | 2006 |
Oleanolic acid, a pentacyclic triterpene attenuates capsaicin-induced nociception in mice: possible mechanisms.
Topics: Adrenergic alpha-Antagonists; Analgesics, Opioid; Animals; Capsaicin; Coloring Agents; Enzyme Inhibitors; Glyburide; Hypoglycemic Agents; KATP Channels; Lamiaceae; Male; Mice; Morphine; Motor Activity; Naloxone; Narcotic Antagonists; NG-Nitroarginine Methyl Ester; Oleanolic Acid; Pain; Pain Measurement; Postural Balance; Potassium Channels, Inwardly Rectifying; Ruthenium Red; Yohimbine | 2006 |
Involvement of I2-imidazoline binding sites in positive and negative morphine analgesia modulatory effects.
Topics: Adrenergic alpha-Antagonists; Analgesics, Opioid; Animals; Benzofurans; CHO Cells; Cricetinae; Idazoxan; Imidazoles; Imidazoline Receptors; Male; Mice; Models, Molecular; Morphine; Naloxone; Narcotic Antagonists; Pain Measurement; Radioligand Assay; Reaction Time; Receptors, Adrenergic, alpha-2; Receptors, Drug; Receptors, Opioid, mu; Yohimbine | 2006 |
Altered antinociceptive efficacy of tramadol over time in rats with painful peripheral neuropathy.
Topics: Adrenergic alpha-Antagonists; Analgesics, Opioid; Animals; Constriction, Pathologic; Dose-Response Relationship, Drug; Hyperalgesia; Male; Naloxone; Narcotic Antagonists; Pain; Pain Measurement; Peripheral Nervous System Diseases; Rats; Rats, Sprague-Dawley; Time Factors; Tramadol; Yohimbine | 2007 |
The synthetic TRH analogue taltirelin exerts modality-specific antinociceptive effects via distinct descending monoaminergic systems.
Topics: Adrenergic alpha-Antagonists; Analgesics; Animals; Biogenic Monoamines; Dose-Response Relationship, Drug; Fenclonine; Hot Temperature; Injections, Intraventricular; Injections, Spinal; Injections, Subcutaneous; Ketanserin; Male; Mice; Mice, Inbred ICR; Naloxone; Narcotic Antagonists; Neural Pathways; Norepinephrine; Oxidopamine; Pain Measurement; Physical Stimulation; Reaction Time; Serotonin; Serotonin Agents; Sympatholytics; Thyrotropin; Thyrotropin-Releasing Hormone; Yohimbine | 2007 |
Analysis of the mechanism of antinociceptive action of niga-ichigoside F1 obtained from Rubus imperialis (Rosaceae).
Topics: Analgesics; Animals; Apomorphine; Atropine; Capsaicin; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Glutamic Acid; Haloperidol; Injections, Intraperitoneal; Male; Mice; Molecular Structure; Morphine; Naloxone; Nitroarginine; Pain; Pain Measurement; Plant Extracts; Rosaceae; Saponins; Yohimbine | 2006 |
Antinociceptive effects of the novel spirocyclopiperazinium salt compound LXM-10 in mice.
Topics: Analgesics; Animals; Atropine; Atropine Derivatives; Body Temperature; Drug Evaluation, Preclinical; Female; Hexamethonium; Male; Mecamylamine; Mice; Mice, Inbred ICR; Motor Activity; Naloxone; Pain; Pain Measurement; Piperazines; Psychomotor Performance; Receptors, Adrenergic, alpha-2; Receptors, Muscarinic; Receptors, Nicotinic; Receptors, Opioid; Yohimbine | 2007 |
Probable involvement of alpha(2C)-adrenoceptor subtype and endogenous opioid peptides in the peripheral antinociceptive effect induced by xylazine.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Analgesics; Animals; Dinoprostone; Dose-Response Relationship, Drug; Hyperalgesia; Idazoxan; Imidazoles; Leucine; Male; Naloxone; Opioid Peptides; Pain; Pain Measurement; Rats; Rats, Wistar; Xylazine; Yohimbine | 2009 |
Identification of an additional supraspinal component to the analgesic mechanism of action of buprenorphine.
Topics: Acetylcholine; Adrenergic alpha-Antagonists; Aminoquinolines; Analgesics, Opioid; Anesthetics, Local; Animals; Benzamides; Brain; Buprenorphine; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fentanyl; GTP-Binding Proteins; Injections, Intraventricular; Injections, Spinal; Male; Mice; Morphine; Naloxone; Narcotic Antagonists; Nociceptin; Nociceptin Receptor; Okadaic Acid; Oligonucleotides, Antisense; Opioid Peptides; Pain; Pain Measurement; Pain Threshold; Pertussis Toxin; Phosphoprotein Phosphatases; Piperazines; Pyridines; Receptor, Serotonin, 5-HT1A; Receptors, Opioid; Serotonin 5-HT1 Receptor Antagonists; Serotonin Antagonists; Signal Transduction; Yohimbine | 2009 |
The antinociceptive effects of intravenous dexmedetomidine in colorectal distension-induced visceral pain in rats: the role of opioid receptors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analgesics, Non-Narcotic; Animals; Catheterization; Clonidine; Colon; Data Interpretation, Statistical; Dexmedetomidine; Dose-Response Relationship, Drug; Injections, Intravenous; Male; Naloxone; Narcotic Antagonists; Pain; Pain Measurement; Physical Stimulation; Quinolizines; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Rectum; Yohimbine | 2009 |
Characterization of two models of drug-induced constipation in mice and evaluation of mustard oil in these models.
Topics: Animals; Atropine; Clonidine; Constipation; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Gastrointestinal Transit; Indoles; Loperamide; Male; Mice; Mice, Inbred Strains; Mustard Plant; Naloxone; Plant Oils; Transient Receptor Potential Channels; TRPA1 Cation Channel; Yohimbine | 2009 |
The synergistic interaction between morphine and maprotiline after intrathecal injection in rats.
Topics: Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Amitriptyline; Analgesics, Opioid; Animals; Antidepressive Agents, Second-Generation; Behavior, Animal; Citalopram; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Injections, Spinal; Male; Maprotiline; Morphine; Naloxone; Narcotic Antagonists; Pain; Pain Measurement; Pain Threshold; Rats; Rats, Wistar; Reaction Time; Selective Serotonin Reuptake Inhibitors; Time Factors; Yohimbine | 2009 |
DNIC-mediated analgesia produced by a supramaximal electrical or a high-dose formalin conditioning stimulus: roles of opioid and alpha2-adrenergic receptors.
Topics: Adrenergic alpha-Antagonists; Afferent Pathways; Analgesia; Analysis of Variance; Animals; Area Under Curve; Conditioning, Psychological; Electric Stimulation; Formaldehyde; Immunohistochemistry; Male; Naloxone; Narcotic Antagonists; Neural Inhibition; Pain; Rats; Rats, Sprague-Dawley; Yohimbine | 2010 |
alpha(1)- and alpha(2)-Adrenoceptor hyporesponsiveness in isolated bisected vas deferens of bile duct-ligated rats.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-2 Receptor Agonists; Animals; Bile Ducts, Extrahepatic; Cholestasis, Extrahepatic; Clonidine; Electric Stimulation; In Vitro Techniques; Ligation; Male; Morphine; Muscle Contraction; Muscle, Smooth; Naloxone; Phenylephrine; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Vas Deferens; Yohimbine | 2010 |
Differential contribution of opioid and noradrenergic mechanisms of tapentadol in rat models of nociceptive and neuropathic pain.
Topics: Adrenergic alpha-2 Receptor Antagonists; Analgesics, Opioid; Analysis of Variance; Animals; Dose-Response Relationship, Drug; Linear Models; Male; Naloxone; Narcotic Antagonists; Neuralgia; Norepinephrine; Pain Measurement; Phenols; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Tapentadol; Yohimbine | 2010 |
Central and peripheral anti-inflammatory effects of maprotiline on carrageenan-induced paw edema in rats.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic beta-Antagonists; Animals; Anti-Inflammatory Agents; Antidepressive Agents, Second-Generation; Carrageenan; Edema; Hormone Antagonists; Indomethacin; Injections, Spinal; Male; Maprotiline; Mifepristone; Naloxone; Narcotic Antagonists; Prazosin; Propranolol; Rats; Rats, Wistar; Yohimbine | 2010 |
Determination of α(2)-adrenoceptor and imidazoline receptor involvement in augmentation of morphine and oxycodone analgesia by agmatine and BMS182874.
Topics: Agmatine; Analgesics; Animals; Dansyl Compounds; Drug Synergism; Idazoxan; Imidazoline Receptors; Male; Mice; Morphine; Naloxone; Oxycodone; Receptors, Adrenergic, alpha-2; Receptors, Endothelin; Yohimbine | 2011 |
Tonic inhibition of allergic itch signaling by the descending noradrenergic system in mice.
Topics: Animals; Bites and Stings; Clonidine; Culicidae; Histamine Antagonists; Hypersensitivity; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Naloxone; Norepinephrine; Pruritus; Receptors, Adrenergic, alpha; Receptors, Adrenergic, alpha-2; Spinal Cord; Yohimbine | 2011 |
Rostroventral medulla-mediated biphasic modulation of the rat cardiosomatic motor reflex.
Topics: Adrenergic alpha-2 Receptor Antagonists; Anesthetics, Local; Animals; Capsaicin; Dose-Response Relationship, Drug; Electric Stimulation; Electromyography; Evoked Potentials, Motor; Functional Laterality; Lidocaine; Male; Medulla Oblongata; Naloxone; Narcotic Antagonists; Neural Pathways; Rats; Rats, Sprague-Dawley; Reflex; Sensory System Agents; Spinal Cord Injuries; Yohimbine | 2011 |
The antinociceptive effects of estradiol on adjuvant-induced hyperalgesia in rats involve activation of adrenergic and serotonergic systems.
Topics: Adrenergic alpha-2 Receptor Antagonists; Analgesics; Animals; Estradiol; Freund's Adjuvant; Hyperalgesia; Injections, Spinal; Male; Methysergide; Naloxone; Narcotic Antagonists; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Serotonin; Serotonin Antagonists; Sympathetic Nervous System; Yohimbine | 2011 |
Assessment of the analgesic effect of centhaquin in mouse tail flick and hot-plate tests.
Topics: Adrenergic alpha-2 Receptor Antagonists; Analgesics; Analgesics, Opioid; Animals; Antihypertensive Agents; Body Temperature; Drug Interactions; Endothelin A Receptor Antagonists; Hot Temperature; Idazoxan; Imidazoline Receptors; Male; Mice; Morphine; Naloxone; Narcotic Antagonists; Pain; Piperazines; Receptor, Endothelin A; Receptors, Adrenergic, alpha-2; Receptors, Opioid; Yohimbine | 2011 |
The mechanisms of antihyperalgesic effect of topiramate in a rat model of inflammatory hyperalgesia.
Topics: Analgesics; Animals; Bicuculline; Carrageenan; Disease Models, Animal; Dose-Response Relationship, Drug; Fructose; Hyperalgesia; Inflammation; Male; Naloxone; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Receptors, GABA-A; Receptors, Opioid; Topiramate; Yohimbine | 2013 |
Venlafaxine and neuropathic pain.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic Uptake Inhibitors; Animals; Cyclohexanols; Diabetes Mellitus, Experimental; Hyperalgesia; Male; Naloxone; Narcotic Antagonists; Neuralgia; p-Chloroamphetamine; Pain Threshold; Rats; Rats, Wistar; Selective Serotonin Reuptake Inhibitors; Serotonin Agents; Venlafaxine Hydrochloride; Yohimbine | 2013 |
Oligopeptidases B from Trypanossoma cruzi and Trypanossoma brucei inhibit inflammatory pain in mice by targeting serotoninergic receptors.
Topics: Adrenergic alpha-2 Receptor Antagonists; Analgesics; Animals; Male; Methysergide; Mice; Naloxone; Narcotic Antagonists; Pain; Pain Measurement; Receptors, Serotonin; Serine Endopeptidases; Serotonin Antagonists; Trypanosoma brucei brucei; Trypanosoma cruzi; Yohimbine | 2013 |
Lack of synergistic interaction between the two mechanisms of action of tapentadol in gastrointestinal transit.
Topics: Adrenergic alpha-2 Receptor Antagonists; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Drug Synergism; Gastrointestinal Transit; Male; Naloxone; Narcotic Antagonists; Phenols; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Tapentadol; Yohimbine | 2014 |
The effect of heroin dependence on resumption of heroin self-administration in rats.
Topics: Animals; Dose-Response Relationship, Drug; Extinction, Psychological; Heroin; Heroin Dependence; Male; Naloxone; Rats; Reinforcement Schedule; Self Administration; Substance Withdrawal Syndrome; Yohimbine | 2014 |
Modulation of imidazoline I2 binding sites by CR4056 relieves postoperative hyperalgesia in male and female rats.
Topics: Adrenergic alpha-2 Receptor Antagonists; Analgesics; Analgesics, Opioid; Animals; Benzofurans; Binding Sites; Drug Synergism; Female; Hyperalgesia; Idazoxan; Imidazoles; Imidazoline Receptors; Male; Morphine; Naloxone; Narcotic Antagonists; Pain, Postoperative; Quinazolines; Rats, Sprague-Dawley; Yohimbine | 2014 |
Antinociceptive effect of intrathecal microencapsulated human pheochromocytoma cell in a rat model of bone cancer pain.
Topics: Adrenal Gland Neoplasms; Alginates; Animals; Biocompatible Materials; Bone Neoplasms; Cell Transplantation; Enkephalins; Female; Humans; Naloxone; Nociceptive Pain; Norepinephrine; Pheochromocytoma; Polylysine; Rats; Rats, Sprague-Dawley; Spinal Cord; Yohimbine | 2014 |
Assessment of mechanisms involved in antinociception produced by the alkaloid caulerpine.
Topics: Alkaloids; Analgesics; Animals; Humans; Indoles; Mice; Naloxone; Nitric Oxide; Nociceptive Pain; Pain Measurement; Receptors, Adrenergic, alpha-2; Receptors, Serotonin, 5-HT3; Tropisetron; Yohimbine | 2014 |
The influence of μ-opioid and noradrenaline reuptake inhibition in the modulation of pain responsive neurones in the central amygdala by tapentadol in rats with neuropathy.
Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Central Amygdaloid Nucleus; Male; Naloxone; Narcotic Antagonists; Neuralgia; Neurons; Norepinephrine; Phenols; Rats, Sprague-Dawley; Receptors, Opioid, mu; Spinal Nerves; Tapentadol; Yohimbine | 2015 |
[The effect of electrical stimulation of nucleus tractus solitarius on cardiac nociception and its spinal cord mechanism in rat].
Topics: Animals; Capsaicin; Electric Stimulation; Heart; Injections, Spinal; Naloxone; Nociception; Rats; Rats, Sprague-Dawley; Reflex; Solitary Nucleus; Spinal Cord; Yohimbine | 2015 |
Inhalation of Cedrus atlantica essential oil alleviates pain behavior through activation of descending pain modulation pathways in a mouse model of postoperative pain.
Topics: Administration, Inhalation; Adrenergic alpha-2 Receptor Antagonists; alpha-Methyltyrosine; Analgesics; Animals; Behavior, Animal; Cedrus; Disease Models, Animal; Dopamine Antagonists; Fenclonine; Foot; Haloperidol; Hyperalgesia; Male; Mice; Motor Activity; Naloxone; Narcotic Antagonists; Oils, Volatile; Pain, Postoperative; Phytotherapy; Serotonin Antagonists; Yohimbine | 2015 |
Determination of residual levels of naloxone, yohimbine, thiophanate, and altrenogest in porcine muscle using QuEChERS with liquid chromatography and triple quadrupole mass spectrometry.
Topics: Animals; Chromatography, High Pressure Liquid; Drug Residues; Food Contamination; Limit of Detection; Meat; Muscles; Naloxone; Solid Phase Extraction; Swine; Tandem Mass Spectrometry; Thiophanate; Trenbolone Acetate; Veterinary Drugs; Yohimbine | 2016 |
Effects of naloxone and yohimbine in polycystic ovary syndrome: a rabbit model study.
Topics: Animals; Body Mass Index; Female; Follicle Stimulating Hormone; Insulin; Insulin Resistance; Luteinizing Hormone; Naloxone; Polycystic Ovary Syndrome; Rabbits; Testosterone; Yohimbine | 2016 |
Gastroprotective and ulcer healing effects of hydroethanolic extract of leaves of Caryocar coriaceum: Mechanisms involved in the gastroprotective activity.
Topics: Animals; Antioxidants; Capsaicin; Chromatography, High Pressure Liquid; Chronic Disease; Disease Models, Animal; Ericales; Ethanol; Female; Flavonoids; Gastrointestinal Motility; Glyburide; Histamine; Indomethacin; Male; Mice; Mucus; Naloxone; NG-Nitroarginine Methyl Ester; Phenols; Phytotherapy; Plant Extracts; Plant Leaves; Protective Agents; Stomach Ulcer; Water; Yohimbine | 2017 |
Anti-hyperalgesic effect of Lippia grata leaf essential oil complexed with β-cyclodextrin in a chronic musculoskeletal pain animal model: Complemented with a molecular docking and antioxidant screening.
Topics: Analgesics; Animals; Antioxidants; beta-Cyclodextrins; Chronic Pain; Disease Models, Animal; Hyperalgesia; Lippia; Male; Methysergide; Mice; Molecular Docking Simulation; Musculoskeletal Pain; Naloxone; Oils, Volatile; Plant Leaves; Proto-Oncogene Proteins c-fos; Spinal Cord Dorsal Horn; Yohimbine | 2017 |
Eslicarbazepine acetate reduces trigeminal nociception: Possible role of adrenergic, cholinergic and opioid receptors.
Topics: Adrenergic Antagonists; Analgesics; Animals; Atropine; Cholinergic Antagonists; Dibenzazepines; Formaldehyde; Male; Mice; Naloxone; Narcotic Antagonists; Pain; Receptors, Adrenergic; Receptors, Cholinergic; Receptors, Opioid; Trigeminal Neuralgia; Yohimbine | 2018 |
Tapentadol in an Experimental Animal Model of Acute Orofacial Pain.
Topics: Acute Pain; Analgesics, Opioid; Animals; Central Amygdaloid Nucleus; Dose-Response Relationship, Drug; Facial Pain; Naloxone; Pain Measurement; Pilot Projects; Rats; Tapentadol; Yohimbine | 2019 |
Bombax costatum enhances piroxicam's efficacy: Possible involvement of alpha-2 adrenergic receptor, opioidergic and arachidonic pathways.
Topics: Analgesics; Animals; Bombax; Humans; Mice; Naloxone; Piroxicam; Rats; Receptors, Adrenergic, alpha-2; Yohimbine | 2022 |
Effect of Immature
Topics: Analgesics; Animals; Dexmedetomidine; Hyperalgesia; Interleukin-6; Male; Naloxone; Pain, Postoperative; Plant Extracts; Rats; Rats, Sprague-Dawley; Rubus; Yohimbine | 2023 |