Page last updated: 2024-09-03

ym 022 and yf 476

ym 022 has been researched along with yf 476 in 8 studies

Compound Research Comparison

Studies
(ym 022)
Trials
(ym 022)
Recent Studies (post-2010)
(ym 022)
Studies
(yf 476)
Trials
(yf 476)
Recent Studies (post-2010) (yf 476)
651843917

Protein Interaction Comparison

ProteinTaxonomyym 022 (IC50)yf 476 (IC50)
Cholecystokinin receptor type ARattus norvegicus (Norway rat)0.502
Gastrin/cholecystokinin type B receptorRattus norvegicus (Norway rat)0.0001

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (25.00)18.2507
2000's5 (62.50)29.6817
2010's0 (0.00)24.3611
2020's1 (12.50)2.80

Authors

AuthorsStudies
Akuzawa, S; Batt, AR; Kendrick, DA; Miyata, K; Nishida, A; Ohta, M; Rooker, DP; Ryder, H; Satoh, M; Semple, G; Szelke, M1
Håkanson, R; Lindström, E; Monstein, HJ; Nilsson, I; Svensson, S1
Ding, XQ; Håkanson, R; Lindström, E; Norlén, P1
Björkqvist, M; Chen, D; Ding, XQ; Håkanson, R; Kitano, M; Norlén, P; Zhao, CM1
Ding, XQ; Håkanson, R; Kitano, M; Nakamura, S; Norlén, P1
Björkqvist, M; Chen, D; de la Cour, CD; Gagnemo-Persson, C; Håkanson, R; Kitano, M; Norlén, P; Zhao, CM1
Chen, D; Håkanson, R; Zhao, CM1
Boyce, M; Burkitt, MD; Dodd, S; Duckworth, CA; Exarchou, K; Fang, Y; Hall, N; Howes, N; Lloyd, KA; Moore, AR; Oxvig, C; Papoutsopoulou, S; Parsons, BN; Pritchard, DM; Rainbow, L; Varro, A1

Reviews

2 review(s) available for ym 022 and yf 476

ArticleYear
CCK2 receptor antagonists: pharmacological tools to study the gastrin-ECL cell-parietal cell axis.
    Regulatory peptides, 1999, Mar-17, Volume: 80, Issue:1-2

    Topics: Animals; Benzodiazepines; Benzodiazepinones; Chromogranin A; Gastric Acid; Gastric Mucosa; Gastrins; Histamine; Histidine Decarboxylase; Hormone Antagonists; Humans; Indoles; Pancreatic Hormones; Parietal Cells, Gastric; Phenylurea Compounds; Receptor, Cholecystokinin B; Receptors, Cholecystokinin; Stomach

1999
Secretory organelles in ECL cells: effects of pharmacological blockade of the gastrin/CCK2 receptor versus its elimination by gene targeting.
    Inflammopharmacology, 2005, Volume: 13, Issue:1-3

    Topics: Animals; Benzodiazepines; Benzodiazepinones; Enterochromaffin-like Cells; Mice; Mice, Knockout; Microscopy, Electron; Organelles; Phenylurea Compounds; Receptor, Cholecystokinin B

2005

Trials

1 trial(s) available for ym 022 and yf 476

ArticleYear
Netazepide Inhibits Expression of Pappalysin 2 in Type 1 Gastric Neuroendocrine Tumors.
    Cellular and molecular gastroenterology and hepatology, 2020, Volume: 10, Issue:1

    Topics: Animals; Benzodiazepines; Benzodiazepinones; Cell Line, Tumor; Disease Models, Animal; Gastric Mucosa; Gastrins; Gene Knockdown Techniques; Humans; Mice; Mice, Transgenic; Neuroendocrine Tumors; Organoids; Phenylurea Compounds; Pregnancy-Associated Plasma Protein-A; Primary Cell Culture; Receptor, Cholecystokinin B; Stomach Neoplasms; Treatment Outcome

2020

Other Studies

5 other study(ies) available for ym 022 and yf 476

ArticleYear
(3R)-N-(1-(tert-butylcarbonylmethyl)-2,3-dihydro-2-oxo-5-(2-pyridyl)-1H-1,4-benzodiazepin-3-yl)-N'-(3-(methylamino)phenyl)urea (YF476): a potent and orally active gastrin/CCK-B antagonist.
    Journal of medicinal chemistry, 1997, Jan-31, Volume: 40, Issue:3

    Topics: Administration, Oral; Animals; Benzodiazepines; Benzodiazepinones; Binding, Competitive; Brain; Devazepide; Dogs; Gastric Acid; Hormone Antagonists; Molecular Structure; Pancreas; Pentagastrin; Phenylurea Compounds; Protein Binding; Rats; Rats, Sprague-Dawley; Receptor, Cholecystokinin B; Receptors, Cholecystokinin; Sincalide; Structure-Activity Relationship

1997
Pharmacological analysis of CCK(2) receptor ligands using COS-7 and SK-N-MC cells, expressing the human CCK(2) receptor.
    Regulatory peptides, 2002, Jan-15, Volume: 103, Issue:1

    Topics: Animals; Binding Sites; Binding, Competitive; Cell Line; Cell Membrane; COS Cells; Gene Expression; Guanosine Triphosphate; Humans; Kinetics; Ligands; Models, Theoretical; Neuroblastoma; Radioligand Assay; Receptor, Cholecystokinin B; Receptors, Cell Surface; Receptors, Cholecystokinin; Structure-Activity Relationship; Transfection; Tumor Cells, Cultured

2002
Effect of cholecystokinin-2 receptor blockade on rat stomach ECL cells. A histochemical, electron-microscopic and chemical study.
    Cell and tissue research, 2000, Volume: 299, Issue:1

    Topics: Animals; Benzodiazepines; Benzodiazepinones; Chromogranin A; Cytoplasmic Granules; Gastrins; Histamine; Histidine Decarboxylase; Hormone Antagonists; Immunohistochemistry; Male; Microscopy, Electron; Omeprazole; Pancreatic Hormones; Parietal Cells, Gastric; Phenylurea Compounds; Rats; Rats, Sprague-Dawley; Receptors, Cholecystokinin; Time Factors

2000
Long-lasting cholecystokinin(2) receptor blockade after a single subcutaneous injection of YF476 or YM022.
    British journal of pharmacology, 2000, Volume: 130, Issue:3

    Topics: Administration, Oral; Animals; Benzodiazepines; Benzodiazepinones; Dose-Response Relationship, Drug; Gastric Acid; Gastric Mucosa; Gastrins; Histidine Decarboxylase; Hormone Antagonists; Injections, Subcutaneous; Male; Phenylurea Compounds; Rats; Rats, Sprague-Dawley; Receptor, Cholecystokinin B; Receptors, Cholecystokinin; Weight Gain

2000
Effects of CCK2 receptor blockade on growth parameters in gastrointestinal tract and pancreas in rats.
    Pharmacology & toxicology, 2001, Volume: 89, Issue:4

    Topics: Animals; Benzodiazepines; Benzodiazepinones; Digestive System; Drug Interactions; Gastrins; Hormone Antagonists; Hyperplasia; Hypertrophy; Male; Omeprazole; Pancreas; Parietal Cells, Gastric; Phenylurea Compounds; Rats; Rats, Sprague-Dawley; Receptor, Cholecystokinin B; Receptors, Cholecystokinin

2001