ym 022 and yf 476
ym 022 has been researched along with yf 476 in 8 studies
Compound Research Comparison
| Studies (ym 022) | Trials (ym 022) | Recent Studies (post-2010) (ym 022) | Studies (yf 476) | Trials (yf 476) | Recent Studies (post-2010) (yf 476) |
|---|---|---|---|---|---|
| 65 | 1 | 8 | 43 | 9 | 17 |
Protein Interaction Comparison
| Protein | Taxonomy | ym 022 (IC50) | yf 476 (IC50) |
|---|---|---|---|
| Cholecystokinin receptor type A | Rattus norvegicus (Norway rat) | 0.502 | |
| Gastrin/cholecystokinin type B receptor | Rattus norvegicus (Norway rat) | 0.0001 |
Research
Studies (8)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (25.00) | 18.2507 |
| 2000's | 5 (62.50) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Akuzawa, S; Batt, AR; Kendrick, DA; Miyata, K; Nishida, A; Ohta, M; Rooker, DP; Ryder, H; Satoh, M; Semple, G; Szelke, M | 1 |
| Håkanson, R; Lindström, E; Monstein, HJ; Nilsson, I; Svensson, S | 1 |
| Ding, XQ; Håkanson, R; Lindström, E; Norlén, P | 1 |
| Björkqvist, M; Chen, D; Ding, XQ; Håkanson, R; Kitano, M; Norlén, P; Zhao, CM | 1 |
| Ding, XQ; Håkanson, R; Kitano, M; Nakamura, S; Norlén, P | 1 |
| Björkqvist, M; Chen, D; de la Cour, CD; Gagnemo-Persson, C; Håkanson, R; Kitano, M; Norlén, P; Zhao, CM | 1 |
| Chen, D; Håkanson, R; Zhao, CM | 1 |
| Boyce, M; Burkitt, MD; Dodd, S; Duckworth, CA; Exarchou, K; Fang, Y; Hall, N; Howes, N; Lloyd, KA; Moore, AR; Oxvig, C; Papoutsopoulou, S; Parsons, BN; Pritchard, DM; Rainbow, L; Varro, A | 1 |
Reviews
2 review(s) available for ym 022 and yf 476
| Article | Year |
|---|---|
CCK2 receptor antagonists: pharmacological tools to study the gastrin-ECL cell-parietal cell axis.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Chromogranin A; Gastric Acid; Gastric Mucosa; Gastrins; Histamine; Histidine Decarboxylase; Hormone Antagonists; Humans; Indoles; Pancreatic Hormones; Parietal Cells, Gastric; Phenylurea Compounds; Receptor, Cholecystokinin B; Receptors, Cholecystokinin; Stomach | 1999 |
Secretory organelles in ECL cells: effects of pharmacological blockade of the gastrin/CCK2 receptor versus its elimination by gene targeting.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Enterochromaffin-like Cells; Mice; Mice, Knockout; Microscopy, Electron; Organelles; Phenylurea Compounds; Receptor, Cholecystokinin B | 2005 |
Trials
1 trial(s) available for ym 022 and yf 476
| Article | Year |
|---|---|
Netazepide Inhibits Expression of Pappalysin 2 in Type 1 Gastric Neuroendocrine Tumors.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Cell Line, Tumor; Disease Models, Animal; Gastric Mucosa; Gastrins; Gene Knockdown Techniques; Humans; Mice; Mice, Transgenic; Neuroendocrine Tumors; Organoids; Phenylurea Compounds; Pregnancy-Associated Plasma Protein-A; Primary Cell Culture; Receptor, Cholecystokinin B; Stomach Neoplasms; Treatment Outcome | 2020 |
Other Studies
5 other study(ies) available for ym 022 and yf 476
| Article | Year |
|---|---|
(3R)-N-(1-(tert-butylcarbonylmethyl)-2,3-dihydro-2-oxo-5-(2-pyridyl)-1H-1,4-benzodiazepin-3-yl)-N'-(3-(methylamino)phenyl)urea (YF476): a potent and orally active gastrin/CCK-B antagonist.
Topics: Administration, Oral; Animals; Benzodiazepines; Benzodiazepinones; Binding, Competitive; Brain; Devazepide; Dogs; Gastric Acid; Hormone Antagonists; Molecular Structure; Pancreas; Pentagastrin; Phenylurea Compounds; Protein Binding; Rats; Rats, Sprague-Dawley; Receptor, Cholecystokinin B; Receptors, Cholecystokinin; Sincalide; Structure-Activity Relationship | 1997 |
Pharmacological analysis of CCK(2) receptor ligands using COS-7 and SK-N-MC cells, expressing the human CCK(2) receptor.
Topics: Animals; Binding Sites; Binding, Competitive; Cell Line; Cell Membrane; COS Cells; Gene Expression; Guanosine Triphosphate; Humans; Kinetics; Ligands; Models, Theoretical; Neuroblastoma; Radioligand Assay; Receptor, Cholecystokinin B; Receptors, Cell Surface; Receptors, Cholecystokinin; Structure-Activity Relationship; Transfection; Tumor Cells, Cultured | 2002 |
Effect of cholecystokinin-2 receptor blockade on rat stomach ECL cells. A histochemical, electron-microscopic and chemical study.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Chromogranin A; Cytoplasmic Granules; Gastrins; Histamine; Histidine Decarboxylase; Hormone Antagonists; Immunohistochemistry; Male; Microscopy, Electron; Omeprazole; Pancreatic Hormones; Parietal Cells, Gastric; Phenylurea Compounds; Rats; Rats, Sprague-Dawley; Receptors, Cholecystokinin; Time Factors | 2000 |
Long-lasting cholecystokinin(2) receptor blockade after a single subcutaneous injection of YF476 or YM022.
Topics: Administration, Oral; Animals; Benzodiazepines; Benzodiazepinones; Dose-Response Relationship, Drug; Gastric Acid; Gastric Mucosa; Gastrins; Histidine Decarboxylase; Hormone Antagonists; Injections, Subcutaneous; Male; Phenylurea Compounds; Rats; Rats, Sprague-Dawley; Receptor, Cholecystokinin B; Receptors, Cholecystokinin; Weight Gain | 2000 |
Effects of CCK2 receptor blockade on growth parameters in gastrointestinal tract and pancreas in rats.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Digestive System; Drug Interactions; Gastrins; Hormone Antagonists; Hyperplasia; Hypertrophy; Male; Omeprazole; Pancreas; Parietal Cells, Gastric; Phenylurea Compounds; Rats; Rats, Sprague-Dawley; Receptor, Cholecystokinin B; Receptors, Cholecystokinin | 2001 |