valproic acid and urea

valproic acid has been researched along with urea in 51 studies

Research

Studies (51)

Timeframe	Studies, this research(%)	All Research%
pre-1990	18 (35.29)	18.7374
1990's	7 (13.73)	18.2507
2000's	14 (27.45)	29.6817
2010's	10 (19.61)	24.3611
2020's	2 (3.92)	2.80

Authors

Authors	Studies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Richens, A	1
Egli, M	1
Araki, Y; Ueki, S; Watanabe, S	1
Borgå, O; Dahlqvist, R; Rane, A; Sjöqvist, F; Walsh, Z	1
Alonso, E; García-España, A; Girbés, J; Rubio, V	1
Hjelm, M; Kay, JD; Oberholzer, V; Seakins, J; Thomas, S	2
Kamoun, PP; Rabier, D	1
Alhayek, G; Alquier, P; Bourrier, P; Kamoun, P; Lorre, G; Rabier, D; Varache, N	1
de Silva, LV; Hjelm, M; Oberholzer, VG; Rolles, CJ; Seakins, JW	1
Chapman, AG	1
Cotariu, D; Zaidman, JL	1
Bartlett, K; Bone, AJ; Koundakjian, PP; Sherratt, HS; Turnbull, DM	1
Coude, FX; Grimber, G; Parvy, P; Petit, F; Rabier, D	1
Turner, AJ; Whittle, SR	1
Hackett, T; Kelton, JG; Powers, P	1
Cathelineau, L; Coudé, FX; Grimber, G; Kamoun, P; Parvy, P; Rabier, D	1
Brewster, D; Muir, NC	1
Treem, WR	1
Horiuchi, M; Imamura, Y; Maruyama, I; Nakamura, N; Saheki, T	1
Dasgupta, A; Jacques, M; Malhotra, D	1
Crossey, MJ; Dasgupta, A	1
Raby, WN	1
Jiménez, C; Lluch-Fernández, MD; Marchante-Serrano, C; Navarro-Quesada, FJ; Vaquero-Abellán, M	1
Chunngam, T; Patarapanich, C; Sooksawate, T; Tantisira, B; Tantisira, MH	1
Calvani, M; Guaitolini, C; Paolone, G; Parisi, G; Parisi, P	1
Doussard-Lefaucheux, S; Jung, P	1
Gadot, N; Korzets, Z; Pomeranz, A; Vainstein, G	1
Bialer, M; Sobol, E; Yagen, B	1
Decruyenaere, J; Dhondt, A; Eloot, S; Segers, H; Vandewoude, K; Vanholder, R; Verstraete, A	1
Aoki, Y; Bialer, M; Fujiwara, M; Okada, A; Onishi, Y; Sobol, E; Yagen, B	1
Bialer, M; Finnell, RH; Lamb, JG; Pappo, O; Sobol, E; Steve White, H; Wilcox, KS; Wlodarczyk, BJ; Yagen, B	1
Jünemann, A; Michelson, G; Stefan, H; Tilz, C; Wang-Tilz, Y	1
Bialer, M; Finnell, RH; Shimshoni, JA; Wlodarczyk, B; Yagen, B	1
Bialer, M; Finnell, RH; Pessah, N; Shimshoni, JA; Wlodarczyk, B; Yagen, B	1
Khongsombat, O; Patarapanich, C; Tantisira, B; Tantisira, MH; Watanabe, H	1
Bialer, M; Shimshoni, JA; Yagen, B	1
Bialer, M; Finnell, RH; Schurig, V; Shimshoni, JA; Wlodarczyk, B; Yagen, B	1
Bialer, M; Fujiwara, M; Noyori, H; Okada, A; Shimshoni, JA; Yagen, B	1
Bialer, M; Devor, M; Kaufmann, D; Shimshoni, JA; Yagen, B	1
Bourque, DL; LaBuzetta, JN; Yao, JZ; Zivin, J	1
Aires, CC; de Almeida, IT; Duran, M; Ijlst, L; Silva, MF; van Cruchten, A; Wanders, RJ	1
Berg, MJ; Braun, KP; Koudijs, SM; Malingré, MM; ter Heine, R; van der Westerlaken, MM; van Maarseveen, EM	1
Arora, S; Brar, R; Kaur, T; Singh, AP; Singh, JP	1
Walker, V	1
Bolkent, S; Ercin, M; Gezginci-Oktayoglu, S; Turkyilmaz, IB; Yanardag, R	1
Carvalho, AF; Dal-Pont, GC; de Souza, CT; Farias, HR; Jornada, LK; Machado, AG; Peterle, BR; Quevedo, J; Resende, WR; Valvassori, SS	1
Gad, AM	1
Beddoes, P; Nerone, G; Tai, C	1
Bora, S; Hasija, Y; Kukal, S; Kukreti, R; Kukreti, S; Mishra, MK; Muthusamy, K; Paul, PR; Saso, L; Singh, A	1

Reviews

8 review(s) available for valproic acid and urea

Article	Year
Interactions with antiepileptic drugs. Drugs, 1977, Volume: 13, Issue:4 Topics: Acetaminophen; Acetazolamide; Anti-Anxiety Agents; Anticoagulants; Anticonvulsants; Carbamazepine; Diazepam; Drug Interactions; Furosemide; Gonadal Steroid Hormones; Griseofulvin; Humans; Phenobarbital; Phenytoin; Primidone; Thiazines; Urea; Valproic Acid; Vitamin D	1977
Valproate and myoclonus. Advances in neurology, 1986, Volume: 43 Topics: 5-Hydroxytryptophan; Amino Acids; Animals; Aspartic Acid; Clonazepam; DDT; Disease Models, Animal; Flurazepam; gamma-Aminobutyric Acid; Glycine; Isoxazoles; Light; Morphine; Muscimol; Myoclonus; Serotonin; Urea; Valproic Acid	1986
Valproic acid and the liver. Clinical chemistry, 1988, Volume: 34, Issue:5 Topics: Amino Acids; Carnitine; Chemical and Drug Induced Liver Injury; Drug Interactions; Fatty Acids; Humans; Liver Diseases; Urea; Valproic Acid	1988
Drug-induced platelet destruction. Seminars in thrombosis and hemostasis, 1982, Volume: 8, Issue:2 Topics: Binding Sites, Antibody; Blood Platelets; Cell Differentiation; Cell Migration Inhibition; Clot Retraction; Complement Fixation Tests; Gold; Heparin; Humans; Immunoglobulin G; Intradermal Tests; Platelet Aggregation; Platelet Factor 3; Prednisone; Quinidine; Ristocetin; Serotonin; Thrombocytopenia; Thromboembolism; Urea; Valproic Acid	1982
Inherited and acquired syndromes of hyperammonemia and encephalopathy in children. Seminars in liver disease, 1994, Volume: 14, Issue:3 Topics: Ammonia; Child; Hepatic Encephalopathy; Humans; Liver Diseases; Metabolism, Inborn Errors; Reye Syndrome; Urea; Valproic Acid	1994
Adult nonhepatic hyperammonemia: a case report and differential diagnosis. The American journal of medicine, 2010, Volume: 123, Issue:10 Topics: Ammonia; Diagnosis, Differential; Humans; Hyperammonemia; Liver Diseases; Male; Metabolism, Inborn Errors; Middle Aged; Urea; Valproic Acid	2010
Ammonia metabolism and hyperammonemic disorders. Advances in clinical chemistry, 2014, Volume: 67 Topics: Ammonia; Animals; Arginine; Biological Transport; Brain; Cell Membrane; Humans; Hyperammonemia; Hyperinsulinism; Liver; Liver Diseases; Pyruvate Carboxylase Deficiency Disease; Syndrome; Urea; Urologic Diseases; Valproic Acid	2014
Insights into Structural Modifications of Valproic Acid and Their Pharmacological Profile. Molecules (Basel, Switzerland), 2021, Dec-24, Volume: 27, Issue:1 Topics: Amides; Animals; Anticonvulsants; Drug Monitoring; Epilepsy; Humans; Molecular Structure; Structure-Activity Relationship; Teratogens; Urea; Valproic Acid	2021

Other Studies

43 other study(ies) available for valproic acid and urea

Article	Year
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
[Drug interactions in antiepileptic combination therapy]. Deutsche medizinische Wochenschrift (1946), 1979, Feb-16, Volume: 104, Issue:7 Topics: Anticonvulsants; Carbamazepine; Drug Interactions; Drug Therapy, Combination; Enzyme Induction; Humans; Phenobarbital; Phenylbutyrates; Phenytoin; Primidone; Thiazines; Time Factors; Urea; Valproic Acid	1979
Changes in sensitivity of mice to anticonvulsant drugs following bilateral olfactory bulb ablations. Japanese journal of pharmacology, 1977, Volume: 27, Issue:2 Topics: Acetazolamide; Animals; Anticonvulsants; Chlordiazepoxide; Diazepam; Dose-Response Relationship, Drug; Electroshock; Male; Mice; Nitrazepam; Olfactory Bulb; Phenobarbital; Phenylacetates; Phenytoin; Trimethadione; Urea; Valproic Acid	1977
Decreased plasma protein binding of phenytoin in patients on valproic acid. British journal of clinical pharmacology, 1979, Volume: 8, Issue:6 Topics: Adolescent; Adult; Blood Proteins; Child; Creatinine; Depression, Chemical; Epilepsy; Humans; Phenytoin; Protein Binding; Serum Albumin; Urea; Valproic Acid	1979
Changes in urea cycle-related metabolites in the mouse after combined administration of valproic acid and an amino acid load. Archives of biochemistry and biophysics, 1989, Aug-01, Volume: 272, Issue:2 Topics: Amino Acids; Ammonia; Animals; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Citrulline; Glutamates; Glutamine; Liver; Mice; Ornithine; Urea; Valproic Acid	1989
Valproate-induced inhibition of urea synthesis and hyperammonaemia in healthy subjects. Lancet (London, England), 1986, Oct-11, Volume: 2, Issue:8511 Topics: Adult; Ammonia; Female; Humans; Male; Middle Aged; Urea; Valproic Acid	1986
Valproate-induced inhibition of urea synthesis. Lancet (London, England), 1987, Jan-03, Volume: 1, Issue:8523 Topics: Acetyltransferases; Amino-Acid N-Acetyltransferase; Humans; Liver; Urea; Valproic Acid	1987
Valproate inhibition of urea synthesis. Lancet (London, England), 1987, Apr-18, Volume: 1, Issue:8538 Topics: Humans; Urea; Valproic Acid	1987
[Cerebral edema with hyperammonemia in valpromide poisoning. Manifestation in an adult, of a partial deficit in type I carbamylphosphate synthetase]. Presse medicale (Paris, France : 1983), 1988, Nov-05, Volume: 17, Issue:39 Topics: Adult; Amino Acid Metabolism, Inborn Errors; Ammonia; Anticonvulsants; Brain Edema; Carbamoyl-Phosphate Synthase (Ammonia); Humans; Male; Suicide, Attempted; Urea; Valproic Acid	1988
Evidence of inherited urea cycle defect in a case of fatal valproate toxicity. British medical journal (Clinical research ed.), 1986, Jan-04, Volume: 292, Issue:6512 Topics: Adult; Ammonia; Child; Child, Preschool; Female; Humans; Male; Metabolism, Inborn Errors; Middle Aged; Orotic Acid; Urea; Valproic Acid	1986
The effects of valproate on intermediary metabolism in isolated rat hepatocytes and intact rats. Biochemical pharmacology, 1983, Jun-15, Volume: 32, Issue:12 Topics: Animals; Gluconeogenesis; In Vitro Techniques; Liver; Male; Oxidation-Reduction; Palmitic Acid; Palmitic Acids; Pyruvates; Pyruvic Acid; Rats; Rats, Inbred Strains; Urea; Valproic Acid	1983
Inhibition of ureagenesis by valproate in rat hepatocytes. Role of N-acetylglutamate and acetyl-CoA. The Biochemical journal, 1983, Oct-15, Volume: 216, Issue:1 Topics: Acetyl Coenzyme A; Animals; Glutamates; In Vitro Techniques; Liver; Male; Rats; Rats, Inbred Strains; Urea; Valproic Acid	1983
Anti-convulsants and brain aldehyde metabolism: inhibitory characteristics of ox brain aldehyde reductase. Biochemical pharmacology, 1981, Jun-01, Volume: 30, Issue:11 Topics: Alcohol Oxidoreductases; Aldehyde Reductase; Aldehydes; Animals; Anticonvulsants; Benzeneacetamides; Brain; Carbamazepine; Cattle; In Vitro Techniques; Isoenzymes; Male; Phenylacetates; Urea; Valproic Acid	1981
A mechanism for valproate-induced hyperammonemia. Advances in experimental medicine and biology, 1982, Volume: 153 Topics: Ammonia; Animals; Citrulline; Glutamates; Male; Mitochondria, Liver; Oxidation-Reduction; Rats; Rats, Inbred Strains; Urea; Valproic Acid	1982
Valproate plasma protein binding in the uremic condition. Clinical pharmacology and therapeutics, 1980, Volume: 27, Issue:1 Topics: Blood Proteins; Charcoal; Creatinine; Dialysis; Female; Humans; Hydrogen-Ion Concentration; Male; Protein Binding; Urea; Uremia; Valproic Acid	1980
Carbamoylphosphate synthetase deficiency in an adult: deterioration due to administration of valproic acid. Journal of inherited metabolic disease, 1993, Volume: 16, Issue:1 Topics: Adult; Alanine; Ammonia; Blood Urea Nitrogen; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Electrophoresis, Polyacrylamide Gel; Female; Humans; Liver; Urea; Valproic Acid	1993
Diminished protein binding capacity of uremic sera for valproate following hemodialysis: role of free fatty acids and uremic compounds. American journal of nephrology, 1996, Volume: 16, Issue:4 Topics: Anticonvulsants; Charcoal; Creatinine; Fatty Acids, Nonesterified; Humans; In Vitro Techniques; Protein Binding; Renal Dialysis; Serum Albumin; Urea; Uremia; Valproic Acid	1996
Elevated free fatty acid concentrations in lipemic sera reduce protein binding of valproic acid significantly more than phenytoin. The American journal of the medical sciences, 1997, Volume: 313, Issue:2 Topics: Bilirubin; Blood Proteins; Charcoal; Creatinine; Fatty Acids, Nonesterified; Humans; Hyperlipidemias; Phenytoin; Protein Binding; Triglycerides; Urea; Valproic Acid	1997
Carnitine for valproic acid-induced hyperammonemia. The American journal of psychiatry, 1997, Volume: 154, Issue:8 Topics: Adult; Ammonia; Bipolar Disorder; Carbamoyl-Phosphate Synthase (Ammonia); Carnitine; Depressive Disorder; Drug Administration Schedule; Female; Humans; Urea; Valproic Acid	1997
[Evaluation of the effect of long term valproic acid treatment on plasma levels of carnitine, ammonia and amino acids related to the urea cycle in pediatric epileptic patients]. Revista de neurologia, 1997, Volume: 25, Issue:143 Topics: Adolescent; Amino Acids; Ammonia; Anticonvulsants; Carnitine; Child; Child, Preschool; Epilepsy; Glutamine; Glycine; Humans; Infant; Infant, Newborn; Ornithine; Prospective Studies; Retrospective Studies; Urea; Valproic Acid	1997
Preliminary evaluation of the anticonvulsant activity of a valproic acid analog: N-(2-propylpentanoyl) urea. Research communications in molecular pathology and pharmacology, 1997, Volume: 97, Issue:2 Topics: Animals; Anticonvulsants; Bicuculline; Central Nervous System; Convulsants; Dose-Response Relationship, Drug; Electroshock; Lethal Dose 50; Male; Mice; Motor Activity; Pentylenetetrazole; Seizures; Sleep; Strychnine; Time Factors; Urea; Valproic Acid	1997
Latent coeliac disease in a child with epilepsy, cerebral calcifications, drug-induced systemic lupus erythematosus and intestinal folic acid malabsorption associated with impairment of folic acid transport across the blood-brain barrier. European journal of pediatrics, 2001, Volume: 160, Issue:5 Topics: Adolescent; Anticonvulsants; Biological Transport; Blood-Brain Barrier; Brain; Brain Diseases; Calcinosis; Celiac Disease; Epilepsy; Ethosuximide; Folic Acid; Humans; Lupus Erythematosus, Systemic; Male; Urea; Valproic Acid	2001
[Visual field defect in a patient given sodium valporate then carbamazepine: possible effect of aminotransferase inhibition]. Revue neurologique, 2002, Volume: 158, Issue:4 Topics: Adult; Amino Acid Metabolism, Inborn Errors; Anticonvulsants; Carbamazepine; Drug Therapy, Combination; Epilepsy; Evoked Potentials, Visual; Female; Humans; Transaminases; Urea; Valproic Acid; Vision Disorders; Visual Fields	2002
Deepening coma in an epileptic patient: the missing link to the urea cycle. Hyperammonaemic metabolic encephalopathy. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2002, Volume: 17, Issue:7 Topics: Anticonvulsants; Atrophy; Cerebellum; Coma; Epilepsy; Female; Humans; Hyperammonemia; Middle Aged; Treatment Outcome; Urea; Valproic Acid	2002
Tetramethylcyclopropyl analogue of a leading antiepileptic drug, valproic acid. Synthesis and evaluation of anticonvulsant activity of its amide derivatives. Journal of medicinal chemistry, 2004, Aug-12, Volume: 47, Issue:17 Topics: Animals; Anticonvulsants; Convulsants; Cyclopropanes; Electroshock; Mice; Pentylenetetrazole; Polyunsaturated Alkamides; Rats; Seizures; Species Specificity; Structure-Activity Relationship; Urea; Valproic Acid	2004
Efficiency of the Genius batch hemodialysis system with low serum solute concentrations: the case of lithium intoxication therapy. American journal of kidney diseases : the official journal of the National Kidney Foundation, 2005, Volume: 46, Issue:5 Topics: Adult; Antimanic Agents; Bipolar Disorder; Diffusion; Equipment Design; Equipment Failure; Female; Hemodialysis Solutions; Humans; Lithium Carbonate; Molecular Weight; Poisoning; Renal Dialysis; Specific Gravity; Urea; Valproic Acid	2005
Teratology study of derivatives of tetramethylcyclopropyl amide analogues of valproic acid in mice. Birth defects research. Part B, Developmental and reproductive toxicology, 2006, Volume: 77, Issue:3 Topics: Abnormalities, Drug-Induced; Amides; Animals; Body Weight; Cesarean Section; Cyclopropanes; Female; Fetus; Mice; Pregnancy; Skeleton; Teratology; Urea; Valproic Acid	2006
Preclinical evaluation of 2,2,3,3-tetramethylcyclopropanecarbonyl-urea, a novel, second generation to valproic acid, antiepileptic drug. Neuropharmacology, 2006, Volume: 51, Issue:4 Topics: Analysis of Variance; Animals; Anticonvulsants; Behavior, Animal; Body Weight; Cells, Cultured; Cerebral Cortex; Cyclopropanes; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Interactions; Humans; Kindling, Neurologic; Male; Membrane Potentials; Mice; Models, Animal; Motor Activity; Neurons; Organ Size; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Rotarod Performance Test; Seizures; Urea; Valproic Acid	2006
Visual field defect during therapy with valproic-acid. European journal of neurology, 2007, Volume: 14, Issue:8 Topics: Adult; Epilepsy; Female; GABA Agents; gamma-Aminobutyric Acid; Humans; Retina; Retinal Degeneration; Time; Transaminases; Urea; Valproic Acid; Vision Disorders; Visual Fields	2007
Potent anticonvulsant urea derivatives of constitutional isomers of valproic acid. Journal of medicinal chemistry, 2007, Dec-13, Volume: 50, Issue:25 Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Epilepsy, Complex Partial; Mice; Rats; Stereoisomerism; Structure-Activity Relationship; Urea; Valproic Acid	2007
Anticonvulsant profile and teratogenicity of 3,3-dimethylbutanoylurea: a potential for a second generation drug to valproic acid. Epilepsia, 2008, Volume: 49, Issue:7 Topics: Animals; Anticonvulsants; Behavior, Animal; Electrodes, Implanted; Half-Life; Hippocampus; Kindling, Neurologic; Male; Mice; Neural Tube Defects; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Teratogens; Urea; Valproic Acid	2008
Acute effects of N-(2-propylpentanoyl)urea on hippocampal amino acid neurotransmitters in pilocarpine-induced seizure in rats. Epilepsy research, 2008, Volume: 79, Issue:2-3 Topics: Amino Acids; Animals; Anticonvulsants; Hippocampus; Male; Microdialysis; Muscarinic Agonists; Neurotransmitter Agents; Pilocarpine; Rats; Rats, Wistar; Seizures; Urea; Valproic Acid	2008
Synthesis and anticonvulsant activity of aromatic tetramethylcyclopropanecarboxamide derivatives. Bioorganic & medicinal chemistry, 2008, Jun-01, Volume: 16, Issue:11 Topics: Administration, Oral; Amides; Animals; Anticonvulsants; Cyclopropanes; Electroshock; Isoxazoles; Mice; Motor Activity; Rats; Seizures; Sulfonamides; Urea; Valproic Acid; Zonisamide	2008
Evaluation of stereoselective anticonvulsant, teratogenic, and pharmacokinetic profile of valnoctylurea (capuride): a chiral stereoisomer of valproic acid urea derivative. Epilepsia, 2010, Volume: 51, Issue:3 Topics: Animals; Anticonvulsants; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Female; Half-Life; Male; Mice; Neural Tube Defects; Pentanoic Acids; Pentylenetetrazole; Pregnancy; Rats; Rats, Sprague-Dawley; Seizures; Stereoisomerism; Structure-Activity Relationship; Teratogens; Urea; Valproic Acid	2010
Anticonvulsant profile and teratogenic evaluation of potent new analogues of a valproic acid urea derivative in NMRI mice. Birth defects research. Part B, Developmental and reproductive toxicology, 2009, Volume: 86, Issue:5 Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Bone and Bones; Deep Sedation; Differential Threshold; Electric Stimulation; Electroshock; Female; Fetal Death; Mice; Mice, Inbred Strains; Motor Activity; Neural Tube Defects; Pentylenetetrazole; Pregnancy; Rats; Rats, Sprague-Dawley; Seizures; Structure-Activity Relationship; Teratogens; Urea; Valproic Acid	2009
Synthesis and evaluation of antiallodynic and anticonvulsant activity of novel amide and urea derivatives of valproic acid analogues. Journal of medicinal chemistry, 2009, Nov-26, Volume: 52, Issue:22 Topics: Amides; Animals; Anticonvulsants; Electroshock; Isomerism; Male; Mice; Pain; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Seizures; Spinal Nerves; Urea; Valproic Acid	2009
New insights on the mechanisms of valproate-induced hyperammonemia: inhibition of hepatic N-acetylglutamate synthase activity by valproyl-CoA. Journal of hepatology, 2011, Volume: 55, Issue:2 Topics: Acyl Coenzyme A; Amino-Acid N-Acetyltransferase; Ammonia; Animals; Anticonvulsants; Citrulline; Disease Models, Animal; Glutamates; Glutamine; Humans; Hyperammonemia; In Vitro Techniques; Liver; Male; Mice; Mice, Inbred C57BL; Models, Biological; Rats; Rats, Wistar; Urea; Valproic Acid	2011
The quantitative effect of serum albumin, serum urea, and valproic acid on unbound phenytoin concentrations in children. Journal of child neurology, 2014, Volume: 29, Issue:6 Topics: Adolescent; Anticonvulsants; Bilirubin; Carbamazepine; Child; Child, Preschool; Databases, Factual; Female; Humans; Infant; Infant, Newborn; Male; Netherlands; Nonlinear Dynamics; Phenytoin; Protein Binding; Retrospective Studies; Serum Albumin; Urea; Valproic Acid	2014
Role of GABAergic activity of sodium valproate against ischemia-reperfusion-induced acute kidney injury in rats. Naunyn-Schmiedeberg's archives of pharmacology, 2014, Volume: 387, Issue:2 Topics: Acute Kidney Injury; Animals; Catalase; Creatinine; GABA Agents; Glutathione; Kidney; L-Lactate Dehydrogenase; Male; Peroxidase; Picrotoxin; Potassium; Protective Agents; Proteinuria; Rats; Rats, Wistar; Receptors, GABA-A; Reperfusion Injury; Sodium; Superoxides; Thiobarbituric Acid Reactive Substances; Urea; Uric Acid; Valproic Acid	2014
Vitamin U has a protective effect on valproic acid-induced renal damage due to its anti-oxidant, anti-inflammatory, and anti-fibrotic properties. Protoplasma, 2016, Volume: 253, Issue:1 Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Blotting, Western; Catalase; Collagen Type I; Creatinine; Female; Fibrosis; Glutathione; Glutathione Transferase; Immunoblotting; Inflammation; Kidney; Lipid Peroxidation; Oxidative Stress; Rats, Sprague-Dawley; Superoxide Dismutase; Transforming Growth Factor beta1; Urea; Valproic Acid; Vitamin U	2016
Lithium and valproate act on the GSK-3β signaling pathway to reverse manic-like behavior in an animal model of mania induced by ouabain. Neuropharmacology, 2017, 05-01, Volume: 117 Topics: Animals; Antimanic Agents; Bipolar Disorder; Disease Models, Animal; Frontal Lobe; Glycogen Synthase Kinase 3 beta; Hippocampus; Lithium Compounds; Locomotion; Male; Ouabain; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Rats, Wistar; Signal Transduction; Thiazoles; Urea; Valproic Acid	2017
Study on the influence of caffeic acid against sodium valproate-induced nephrotoxicity in rats. Journal of biochemical and molecular toxicology, 2018, Volume: 32, Issue:8 Topics: Animals; Anticonvulsants; Biomarkers; Caffeic Acids; Caspase 3; Creatinine; Inflammation; Interferon-gamma; Kidney; Male; Malondialdehyde; NF-kappa B; Nitric Oxide Synthase Type II; Rats, Sprague-Dawley; Receptors, Notch; Signal Transduction; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha; Urea; Valproic Acid	2018
Status epilepticus secondary to hyperammonaemia: a late presentation of an undiagnosed urea cycle defect. BMJ case reports, 2021, May-31, Volume: 14, Issue:5 Topics: Adult; Child; Humans; Hyperammonemia; Ornithine Carbamoyltransferase Deficiency Disease; Status Epilepticus; Urea; Valproic Acid	2021