uracil and thiophenes
uracil has been researched along with thiophenes in 47 studies
Research
Studies (47)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (8.51) | 18.7374 |
| 1990's | 7 (14.89) | 18.2507 |
| 2000's | 13 (27.66) | 29.6817 |
| 2010's | 20 (42.55) | 24.3611 |
| 2020's | 3 (6.38) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Duffy, EM; Jorgensen, WL | 1 |
| Tamiya, H | 1 |
| Harshman, RB; Yamazaki, H | 2 |
| Turnock, G; Wild, DG | 1 |
| Gallucci, JC; Mathur, N; Shechter, H | 1 |
| Drengler, R; Eckardt, J; Eckhardt, G; Villalona-Calero, M; Von Hoff, D | 1 |
| DeGoeij, K; Mester, J; Sluyser, M | 1 |
| Punt, CJ | 1 |
| Adjei, AA | 1 |
| Cao, S; Rustum, YM | 1 |
| Bekradda, M; Cvitkovic, E | 1 |
| Cunningham, D; James, RD | 1 |
| Reimer, P; Rückle-Lanz, H | 1 |
| Holen, KD; Saltz, LB | 1 |
| Fishman, AD; Wadler, S | 1 |
| Glimelius, B | 1 |
| Cats, A | 1 |
| Acevedo, O; Carter, L; Chen, C; Connors, PJ; Fisher, A; Gross, TD; Guo, Z; Moorjani, M; Rowbottom, MW; Saunders, J; Struthers, RS; Sullivan, SK; Tucci, FC; Xie, Q; Zhu, YF | 1 |
| Berger, SH; Connor, EE; Li, L; Wyatt, MD | 1 |
| Baron, O; Ila, H; Knochel, P; Wagner, AJ | 1 |
| Luo, Y; Walla, M; Wyatt, MD | 1 |
| Haraguchi, K; Matsui, H; Takami, S; Tanaka, H | 1 |
| Davies, AJ; Halestrap, AP; Murray, CM; Ovens, MJ; Wilson, MC | 1 |
| Halestrap, AP; Manoharan, C; Murray, CM; Ovens, MJ; Wilson, MC | 1 |
| Chiche, J; Critchlow, SE; Ilc, K; Ilk, K; Le Floch, R; Marchiq, I; Murray, CM; Naiken, T; Pouysségur, J; Roux, D; Simon, MP | 1 |
| Bouzin, C; Draoui, N; Feron, O; Riant, O; Schicke, O; Seront, E; Sonveaux, P | 1 |
| Harrison, H; Hulit, J; Lamb, R; Lisanti, MP; Smith, DL; Sotgia, F | 1 |
| Halestrap, AP; Nancolas, B; Sessions, RB | 1 |
| Morris, ME; Morse, BL; Vijay, N | 1 |
| Abe, M; Amachi, R; Hanson, DJ; Harada, T; Hiasa, M; Horikawa, K; Itoh, K; Matsumoto, T; Miki, H; Nakamura, S; Oda, A; Teramachi, J; Tsuji, D | 1 |
| Hirate, M; Kutoh, E; Murayama, T; Wada, A | 1 |
| Guo, Y; Jiang, L | 1 |
| Ahn, SM; Chang, WJ; Cho, JH; Jung, KS; Kang, WK; Kim, HS; Kim, KM; Kim, ST; Kim, SY; Lee, I; Lee, J; Lee, JY; Lee, S; Lim, HY; Lim, SH; Park, JO; Park, SH; Park, YS; Song, HN; Yoo, KH | 1 |
| Becker, HM; Deitmer, JW; Forero-Quintero, LS | 1 |
| MacGregor, GG; Pivovarova, AI | 1 |
| Aglietta, M; Bonzano, A; Cagnazzo, C; Depetris, I; Filippi, R; Leone, F; Marino, D | 1 |
| Bastien, E; Becker, HM; Chaltin, P; Corbet, C; Doix, B; Draoui, N; Feron, O; Jordan, BF; Marchand, A; Mignion, L; Riant, O; Schakman, O; Vanherck, JC | 1 |
| Guan, X; Morris, ME; Ruszaj, D | 1 |
| Eichner, R; Girardi, E; Hashimoto, M; Superti-Furga, G | 1 |
| Bou Zerdan, R; Castellano, RK; Fagnani, DE | 1 |
| Guan, X; Morris, ME; Rodriguez-Cruz, V | 1 |
| Adak, S; Begley, TP | 1 |
| Juvale, K; Puri, S | 1 |
| Eliopoulos, E; Papakonstantinou, E; Thireou, T; Vlachakis, D; Vlachoyiannopoulos, PG | 1 |
| Huang, G; Li, W; Liu, H; Luo, S; Lv, X; Wang, Y; Zhou, D | 1 |
Reviews
13 review(s) available for uracil and thiophenes
| Article | Year |
|---|---|
New anticancer agents in clinical development.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Deoxycytidine; Enzyme Inhibitors; Fluorouracil; Gemcitabine; Humans; Neoplasms; Polysaccharides, Bacterial; Prodrugs; Quinazolines; Tegafur; Thiophenes; Thymidylate Synthase; Uracil | 1995 |
New drugs in the treatment of colorectal carcinoma.
Topics: Antibodies, Monoclonal; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Clinical Trials as Topic; Colorectal Neoplasms; Deoxycytidine; Fluorouracil; Humans; Irinotecan; Organoplatinum Compounds; Oxaliplatin; Quinazolines; Tegafur; Thiophenes; Topotecan; Trimetrexate; Uracil | 1998 |
A review of the pharmacology and clinical activity of new chemotherapy agents for the treatment of colorectal cancer.
Topics: Antineoplastic Agents; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Fluorouracil; Glutamates; Guanine; Humans; Pemetrexed; Platinum Compounds; Pyridines; Quinazolines; Tegafur; Thiophenes; Uracil | 1999 |
New drugs in therapy of colorectal cancer: preclinical studies.
Topics: Animals; Antimetabolites, Antineoplastic; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Dihydrouracil Dehydrogenase (NADP); Drug Combinations; Drug Evaluation, Preclinical; Enzyme Inhibitors; Fluorouracil; Folic Acid Antagonists; Humans; Oxidoreductases; Prodrugs; Quinazolines; Tegafur; Thiophenes; Thymidine Phosphorylase; Thymidylate Synthase; Uracil | 1999 |
Oxaliplatin: a new therapeutic option in colorectal cancer.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Clinical Trials as Topic; Colorectal Neoplasms; Deoxycytidine; Drug Combinations; Drug Synergism; Fluorouracil; Humans; Irinotecan; Organoplatinum Compounds; Oxaliplatin; Quinazolines; Tegafur; Thiophenes; Uracil | 1999 |
Integrating the oral fluoropyrimidines into the management of advanced colorectal cancer.
Topics: Administration, Oral; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Fluorouracil; Humans; Irinotecan; Leucovorin; Pyrimidines; Quinazolines; Tegafur; Thiophenes; Uracil | 2001 |
[New therapeutic options in chemotherapy of advanced colorectal cancer].
Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Carcinoma; Clinical Trials as Topic; Colorectal Neoplasms; Deoxycytidine; Disease-Free Survival; Fluorouracil; Humans; Irinotecan; Leucovorin; Neoplasm Staging; Organoplatinum Compounds; Oxaliplatin; Quinazolines; Tegafur; Thiophenes; Uracil | 2001 |
New therapies, new directions: advances in the systemic treatment of metastatic colorectal cancer.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colorectal Neoplasms; Fluorouracil; Forecasting; Humans; Irinotecan; Neoplasm Metastasis; Organoplatinum Compounds; Oxaliplatin; Quinazolines; Tegafur; Thiophenes; Trimetrexate; Uracil | 2001 |
Advances in the treatment of metastatic colorectal cancer.
Topics: Administration, Oral; Antibodies, Monoclonal; Antineoplastic Agents; Camptothecin; Cancer Vaccines; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Drug Administration Schedule; Fluorouracil; Humans; Irinotecan; Liver Neoplasms; Neoplasm Metastasis; Organoplatinum Compounds; Oxaliplatin; Prodrugs; Quinazolines; Randomized Controlled Trials as Topic; Thiophenes; Uracil | 2001 |
Palliative treatment of patients with colorectal cancer.
Topics: Antimetabolites, Antineoplastic; Camptothecin; Colorectal Neoplasms; Disease Progression; Enzyme Inhibitors; Fluorouracil; Humans; Irinotecan; Leucovorin; Liver Neoplasms; Palliative Care; Quinazolines; Survival Analysis; Tegafur; Thiophenes; Thymidylate Synthase; Topoisomerase I Inhibitors; Treatment Outcome; Uracil | 2003 |
New developments in systemic chemotherapy in advanced colorectal cancer.
Topics: Administration, Oral; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Capecitabine; Cetuximab; Colorectal Neoplasms; Deoxycytidine; Fluorouracil; Humans; Infusions, Intravenous; Irinotecan; Neoplasm Metastasis; Neoplasm Staging; Organoplatinum Compounds; Oxaliplatin; Quinazolines; Tegafur; Thiophenes; Uracil | 2003 |
Fluoropyrimidine-induced cardiotoxicity.
Topics: Acetates; Capecitabine; Cardiotoxicity; Cardiovascular Diseases; Drug Combinations; Fluorouracil; Humans; Neoplasms; Pyrimidines; Pyrrolidines; Quinazolines; Thiophenes; Thymine; Trifluridine; Uracil; Uridine | 2018 |
Monocarboxylate transporter 1 and 4 inhibitors as potential therapeutics for treating solid tumours: A review with structure-activity relationship insights.
Topics: Antineoplastic Agents; Drug Resistance, Neoplasm; Humans; Monocarboxylic Acid Transporters; Muscle Proteins; Neoplasms; Pyrimidinones; Structure-Activity Relationship; Symporters; Thiophenes; Uracil | 2020 |
Trials
1 trial(s) available for uracil and thiophenes
| Article | Year |
|---|---|
Ipragliflozin as an Initial Therapy in Drug Naïve Subjects with Type 2 Diabetes.
Topics: Blood Glucose; Body Mass Index; Diabetes Mellitus, Type 2; Female; Glucosides; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Male; Middle Aged; Piperidines; Prospective Studies; Thiophenes; Uracil | 2016 |
Other Studies
33 other study(ies) available for uracil and thiophenes
| Article | Year |
|---|---|
Prediction of drug solubility from Monte Carlo simulations.
Topics: Monte Carlo Method; Pharmaceutical Preparations; Solubility | 2000 |
Cell differentiation in Chlorella.
Topics: Alanine; Antimetabolites; Azaguanine; Barbiturates; Caffeine; Cell Differentiation; Cell Division; Chloramphenicol; Dihydrostreptomycin Sulfate; Eukaryota; In Vitro Techniques; Microscopy, Electron; Protein Biosynthesis; Sulfates; Thiophenes; Triazines; Uracil | 1963 |
MSI accumulation induced by sodium chloride.
Topics: Alanine; Arginine; Bacterial Proteins; Carbon Isotopes; Chloramphenicol; Chromatography, Thin Layer; Culture Media; Drug Stability; Escherichia coli; Genetics, Microbial; Guanine Nucleotides; Hydroxides; Hypertonic Solutions; Kinetics; Mutation; Phosphoric Acids; Phosphorus Isotopes; Potassium; Rifampin; RNA, Bacterial; Sodium Chloride; Thiophenes; Uracil | 1972 |
Formation of ppGpp in a relaxed and stringent strain of Escherichia coli during diauxie lag.
Topics: Alanine; Autoradiography; Bacterial Proteins; Carbon Isotopes; Chromatography, Thin Layer; Escherichia coli; Genetics, Microbial; Glucose; Guanine Nucleotides; Mutation; Phosphates; Phosphorus Isotopes; RNA, Bacterial; Succinates; Thiophenes; Uracil | 1971 |
Synthesis of ribonucleic acid and protein during inhibition of Escherichia coli by analogues of amino acids.
Topics: Amino Acids; Bacterial Proteins; Escherichia coli; Methionine; Mutation; Phenylalanine; Propionates; RNA, Bacterial; Thiophenes; Tryptophan; Uracil | 1966 |
(Z)-5-(2-thienylmethylene)-2,4-imidazolidinedione.
Topics: Crystallography, X-Ray; Hot Temperature; Hydrogen Bonding; Imidazoles; Imidazolidines; Models, Molecular; Molecular Conformation; Molecular Structure; Thiophenes; Uracil | 1995 |
Modulation of [5-125I]iododeoxyuridine incorporation into tumour and normal tissue DNA by methotrexate and thymidylate synthase inhibitors.
Topics: Animals; Antimetabolites, Antineoplastic; Dihydrouracil Dehydrogenase (NAD+); DNA, Neoplasm; Female; Fluorouracil; Idoxuridine; Intestine, Small; Iodine Radioisotopes; Liver; Mammary Neoplasms, Experimental; Methotrexate; Mice; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Quinazolines; Thiophenes; Thymidylate Synthase; Uracil | 1996 |
Synthesis and structure-activity relationships of uracil derived human GnRH receptor antagonists: (R)-3-[2-(2-amino)phenethyl]-1-(2,6-difluorobenzyl)-6-methyluracils containing a substituted thiophene or thiazole at C-5.
Topics: Humans; Receptors, LHRH; Structure-Activity Relationship; Thiazoles; Thiophenes; Uracil | 2004 |
Determination of apoptosis, uracil incorporation, DNA strand breaks, and sister chromatid exchanges under conditions of thymidylate deprivation in a model of BER deficiency.
Topics: Animals; Apoptosis; Cell Line; Cells, Cultured; DNA Damage; DNA Polymerase beta; DNA Repair; Dose-Response Relationship, Drug; Embryo, Mammalian; Fibroblasts; Humans; Mice; Poly Adenosine Diphosphate Ribose; Quinazolines; Sister Chromatid Exchange; Thiophenes; Thymidylate Synthase; Time Factors; Uracil; Uracil-DNA Glycosidase | 2005 |
Chemotherapy of metastatic colorectal cancer: fluorouracil plus folinic acid and irinotecan or oxaliplatin.
Topics: Antibodies, Monoclonal; Antineoplastic Agents; Camptothecin; Chemotherapy, Adjuvant; Clinical Trials as Topic; Colorectal Neoplasms; Deoxycytidine; Drug Therapy, Combination; Fluorouracil; Humans; Leucovorin; Neoplasm Metastasis; Organoplatinum Compounds; Quinazolines; Tegafur; Thiophenes; Treatment Outcome; Uracil | 2005 |
Functionalized magnesium organometallics as versatile intermediates for the synthesis of polyfunctional heterocycles.
Topics: Antipyrine; Combinatorial Chemistry Techniques; Esters; Furans; Heterocyclic Compounds; Imidazoles; Imines; Iodides; Magnesium; Models, Chemical; Nitriles; Organometallic Compounds; Pyridines; Pyrroles; Quinolines; Thiazoles; Thiophenes; Uracil | 2006 |
Uracil incorporation into genomic DNA does not predict toxicity caused by chemotherapeutic inhibition of thymidylate synthase.
Topics: Blotting, Western; Capecitabine; Cell Cycle; Cell Line; Deoxycytidine; DNA; DNA Primers; DNA Repair; Fluorouracil; Green Fluorescent Proteins; Humans; Mass Spectrometry; Quinazolines; Thiophenes; Thymidylate Synthase; Uracil; Uracil-DNA Glycosidase | 2008 |
Additive Pummerer reaction of 3,5-O-(di-tert-butyl)silylene-4-thiofuranoid glycal: a high-yield and beta-selective entry to 4'-thioribonucleosides.
Topics: 2-Aminopurine; Cytosine; Purines; Ribonucleosides; Siloxanes; Thionucleosides; Thiophenes; Thymine; Uracil | 2009 |
AR-C155858 is a potent inhibitor of monocarboxylate transporters MCT1 and MCT2 that binds to an intracellular site involving transmembrane helices 7-10.
Topics: Animals; Binding Sites; Catalytic Domain; Chickens; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Erythrocytes; Monocarboxylic Acid Transporters; Phenylalanine; Protein Binding; Protein Structure, Secondary; Protein Structure, Tertiary; Rats; Symporters; Thiophenes; Uracil; Xenopus laevis | 2010 |
The inhibition of monocarboxylate transporter 2 (MCT2) by AR-C155858 is modulated by the associated ancillary protein.
Topics: Animals; Basigin; Erythrocytes; Glycoproteins; Kinetics; Lactic Acid; Membrane Proteins; Monocarboxylic Acid Transporters; Mutant Proteins; Oocytes; Rabbits; Rats; Recombinant Proteins; Symporters; Thiophenes; Uracil; Xenopus laevis; Xenopus Proteins | 2010 |
CD147 subunit of lactate/H+ symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors.
Topics: Basigin; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; DNA Primers; Flow Cytometry; Fluorescent Antibody Technique; Gene Knockout Techniques; Gene Silencing; Glycolysis; Humans; Immunohistochemistry; Lactic Acid; Monocarboxylic Acid Transporters; Muscle Proteins; Oxygen Consumption; Protein Subunits; Symporters; Thiophenes; Uracil | 2011 |
Antitumor activity of 7-aminocarboxycoumarin derivatives, a new class of potent inhibitors of lactate influx but not efflux.
Topics: Animals; Breast Neoplasms; Colorectal Neoplasms; Coumarins; Female; HCT116 Cells; Humans; Lactic Acid; MCF-7 Cells; Mice; Neoplasm Recurrence, Local; Prognosis; Thiophenes; Uracil | 2014 |
Mitochondria as new therapeutic targets for eradicating cancer stem cells: Quantitative proteomics and functional validation via MCT1/2 inhibition.
Topics: Breast Neoplasms; Cell Line, Tumor; Female; Humans; MCF-7 Cells; Mitochondria; Mitochondrial Proteins; Molecular Targeted Therapy; Monocarboxylic Acid Transporters; Neoplastic Stem Cells; Proteomics; Symporters; Thiophenes; Uracil | 2014 |
Identification of key binding site residues of MCT1 for AR-C155858 reveals the molecular basis of its isoform selectivity.
Topics: Amino Acid Substitution; Amino Acids; Animals; Binding Sites; Biological Transport; Female; Gene Expression; Humans; Lactic Acid; Mice; Molecular Docking Simulation; Monocarboxylic Acid Transporters; Muscle Proteins; Mutagenesis, Site-Directed; Oocytes; Protein Binding; Rats; Recombinant Proteins; Symporters; Thiophenes; Uracil; Xenopus laevis | 2015 |
A Novel Monocarboxylate Transporter Inhibitor as a Potential Treatment Strategy for γ-Hydroxybutyric Acid Overdose.
Topics: Administration, Intravenous; Administration, Oral; Animals; Antidotes; Brain; Cell Line; Drug Overdose; Kidney; Male; Metabolic Clearance Rate; Monocarboxylic Acid Transporters; Rats, Sprague-Dawley; Renal Reabsorption; Respiratory Insufficiency; Respiratory Rate; Sodium Oxybate; Thiophenes; Tissue Distribution; Uracil | 2015 |
Effective impairment of myeloma cells and their progenitors by blockade of monocarboxylate transportation.
Topics: Cell Death; Cell Line, Tumor; Coumaric Acids; Gene Knockdown Techniques; Humans; Hydrogen-Ion Concentration; Metformin; Molecular Targeted Therapy; Monocarboxylic Acid Transporters; Multiple Myeloma; Muscle Proteins; Neoplastic Stem Cells; Symporters; Thiophenes; Uracil | 2015 |
Organic anion transporting polypeptide 2 transports valproic acid in rat brain microvascular endothelial cells.
Topics: Acetonitriles; Animals; Animals, Newborn; Anticonvulsants; Brain; Cells, Cultured; Dose-Response Relationship, Drug; Endothelial Cells; Enzyme Inhibitors; Gene Expression Regulation; Microvessels; Organic Anion Transporters; Pregnenolone; Rats; Rats, Wistar; RNA, Messenger; RNA, Small Interfering; Thiophenes; Time Factors; Uracil; Valproic Acid | 2016 |
MCT4 as a potential therapeutic target for metastatic gastric cancer with peritoneal carcinomatosis.
Topics: Adult; Aged; Aged, 80 and over; Animals; Antineoplastic Agents; Cell Proliferation; Cell Survival; Female; Humans; Lactic Acid; Male; Mice, Inbred BALB C; Mice, Nude; Middle Aged; Monocarboxylic Acid Transporters; Muscle Proteins; Peritoneal Neoplasms; RNA Interference; RNA, Small Interfering; Stomach Neoplasms; Symporters; Thiophenes; Up-Regulation; Uracil; Xenograft Model Antitumor Assays | 2016 |
Reduction of epileptiform activity in ketogenic mice: The role of monocarboxylate transporters.
Topics: 3-Hydroxybutyric Acid; Animals; Astrocytes; Brain; Diet, Ketogenic; Disease Models, Animal; Epilepsy; Gene Expression Regulation; Glycolysis; Ketone Bodies; Lactic Acid; Mice; Mice, Inbred C57BL; Microtomy; Monocarboxylic Acid Transporters; Neurons; Primary Cell Culture; Seizures; Signal Transduction; Symporters; Thiophenes; Tissue Culture Techniques; Uracil | 2017 |
Glucose-dependent growth arrest of leukemia cells by MCT1 inhibition: Feeding Warburg's sweet tooth and blocking acid export as an anticancer strategy.
Topics: Antineoplastic Agents; Cell Cycle Checkpoints; Glucose; Growth Inhibitors; Humans; K562 Cells; Leukemia; MCF-7 Cells; Monocarboxylic Acid Transporters; Symporters; Thiophenes; Uracil | 2018 |
Interruption of lactate uptake by inhibiting mitochondrial pyruvate transport unravels direct antitumor and radiosensitizing effects.
Topics: Animals; Antineoplastic Agents; Biological Transport; Cell Line, Tumor; Female; Gene Silencing; Glucose; Glycolysis; Humans; Ion Transport; Lactic Acid; Male; MCF-7 Cells; Mice; Mice, Inbred C57BL; Mitochondria; Monocarboxylic Acid Transporters; Muscle Proteins; Neoplasm Transplantation; Oxygen; Pyruvic Acid; Radiation-Sensitizing Agents; Rats; RNA, Small Interfering; Symporters; Thiophenes; Uracil; Xenopus laevis | 2018 |
Development and validation of a liquid chromatography tandem mass spectrometry assay for AZD3965 in mouse plasma and tumor tissue: Application to pharmacokinetic and breast tumor xenograft studies.
Topics: Acetonitriles; Animals; Atmospheric Pressure; Breast Neoplasms; Cell Line, Tumor; Chromatography, Liquid; Female; Heterografts; Mice; Plasma; Pyrimidines; Pyrimidinones; Reproducibility of Results; Tandem Mass Spectrometry; Thiophenes; Uracil | 2018 |
Detection of Chemical Engagement of Solute Carrier Proteins by a Cellular Thermal Shift Assay.
Topics: Biological Assay; Excitatory Amino Acid Transporter 2; Formates; Glutamate Plasma Membrane Transport Proteins; Heating; HEK293 Cells; Humans; Lactic Acid; Ligands; Monocarboxylic Acid Transporters; Protein Binding; Protein Stability; Pyrimidinones; Thiophenes; Uracil | 2018 |
Synthesis, Optoelectronic Properties, Self-Association, and Base Pairing of Nucleobase-Functionalized Oligothiophenes.
Topics: Adenine; Base Pairing; Chloroform; Cytosine; Dimerization; Dimethylformamide; Electrochemical Techniques; Guanine; Hydrogen Bonding; Molecular Structure; Semiconductors; Solvents; Thermodynamics; Thiophenes; Uracil | 2018 |
Cellular Uptake of MCT1 Inhibitors AR-C155858 and AZD3965 and Their Effects on MCT-Mediated Transport of L-Lactate in Murine 4T1 Breast Tumor Cancer Cells.
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Coumaric Acids; Drug Screening Assays, Antitumor; Female; Humans; Hydrogen-Ion Concentration; Lactic Acid; Mice; Monocarboxylic Acid Transporters; Pyrimidinones; Symporters; Thiophenes; Uracil | 2019 |
Flavin-N5-oxide intermediates in dibenzothiophene, uracil, and hexachlorobenzene catabolism.
Topics: Bacterial Proteins; Biocatalysis; Enzyme Assays; Escherichia coli; Flavins; Hexachlorobenzene; Oxygenases; Rhodococcus; Thiophenes; Uracil | 2019 |
A Holistic Evolutionary and 3D Pharmacophore Modelling Study Provides Insights into the Metabolism, Function, and Substrate Selectivity of the Human Monocarboxylate Transporter 4 (hMCT4).
Topics: Animals; Antineoplastic Agents; Binding Sites; Biological Transport; Drug Design; Glycolysis; Humans; Lactic Acid; Molecular Docking Simulation; Monocarboxylic Acid Transporters; Muscle Proteins; Phloretin; Phylogeny; Protein Binding; Protein Conformation, alpha-Helical; Protein Interaction Domains and Motifs; Protein Isoforms; Pyrimidinones; Quercetin; Reserpine; Structural Homology, Protein; Substrate Specificity; Thiophenes; Uracil | 2021 |
Folic acid alleviates age-related cognitive decline and inhibits apoptosis of neurocytes in senescence-accelerated mouse prone 8: deoxythymidine triphosphate biosynthesis as a potential mechanism.
Topics: Aging; Animals; Apoptosis; Brain; Cognitive Dysfunction; Dietary Supplements; Folic Acid; Male; Memory; Mice; Morris Water Maze Test; Neurons; Quinazolines; Telomere Shortening; Thiophenes; Thymidylate Synthase; Thymine Nucleotides; Uracil | 2021 |