tretinoin has been researched along with morin* in 1 studies
1 other study(ies) available for tretinoin and morin
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Retinoic acid grafted to hyaluronan for skin delivery: Synthesis, stability studies, and biological evaluation.
All-trans retinoic acid (ATRA) was grafted to hyaluronan (HA) via esterification. The reaction was mediated by mixed anhydrides. A perfect control of the degree of substitution (0.5-7.5%) was obtained by varying the molar ratio of retinoic acid in the feed. The degree of substitution plays a significant role in the long-term stability. The photodegradation of HA-ATRA upon UVA irradiation resulted in β-ionone, β-cyclocitral and 5,6-epoxy-(E)-retinoic acid. The photostability of the conjugate had increased with the combination with morin. The chemical structure of HA-ATRA and its degradation products was elucidated using NMR spectroscopy, SEC-MALLS, and gas chromatography-mass spectrometry (GC-MS). ATRA did not loss its biological activity after conjugation, as demonstrated by gene expression. The derivative was able to penetrate across the stratum corneum. Besides, HA-ATRA downregulated the expression of anti-inflammatory interleukins 6 and 8. HA-ATRA would be expected to be used for transdermal drug delivery or cosmetics. Topics: Administration, Cutaneous; Anhydrides; Animals; Antioxidants; Esterification; Flavonoids; Hyaluronic Acid; Mice; NIH 3T3 Cells; Norisoprenoids; Photolysis; Skin; Tretinoin; Ultraviolet Rays | 2020 |