tifluadom has been researched along with u 69593 in 7 studies
| Studies (tifluadom) | Trials (tifluadom) | Recent Studies (post-2010) (tifluadom) | Studies (u 69593) | Trials (u 69593) | Recent Studies (post-2010) (u 69593) |
|---|---|---|---|---|---|
| 78 | 0 | 0 | 524 | 0 | 75 |
| Protein | Taxonomy | tifluadom (IC50) | u 69593 (IC50) |
|---|---|---|---|
| Kappa-type opioid receptor | Rattus norvegicus (Norway rat) | 0.0006 | |
| Mu-type opioid receptor | Homo sapiens (human) | 0.194 | |
| Delta-type opioid receptor | Homo sapiens (human) | 3.6437 | |
| Kappa-type opioid receptor | Cavia porcellus (domestic guinea pig) | 0.0021 | |
| Kappa-type opioid receptor | Homo sapiens (human) | 0.058 | |
| Mu-type opioid receptor | Cavia porcellus (domestic guinea pig) | 0.588 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (28.57) | 18.7374 |
| 1990's | 4 (57.14) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Anzini, M; Cappelli, A; Clarke, GD; De Benedetti, PG; Mennuni, L; Menziani, MC; Sbacchi, M; Vomero, S | 1 |
| Fujii, H; Hirono, S; Nagase, H; Yamaotsu, N | 1 |
| Caliezi, A; Drack, E; Halter, F; Scheurer, U; Varga, L; Wenger, F | 1 |
| Bykov, V; De Costa, BR; France, CP; Jacobson, AE; Rice, KC; Rothman, RB; Woods, JH | 1 |
| Frey, HH | 1 |
| de Costa, BR; Haaseth, RC; Horan, PJ; Hruby, VJ; Porreca, F; Rice, K | 1 |
| Heyliger, SO; Jackson, C; Rice, KC; Rothman, RB | 1 |
7 other study(ies) available for tifluadom and u 69593
| Article | Year |
|---|---|
Synthesis, biological evaluation, and quantitative receptor docking simulations of 2-[(acylamino)ethyl]-1,4-benzodiazepines as novel tifluadom-like ligands with high affinity and selectivity for kappa-opioid receptors.
Topics: Amino Acid Sequence; Analgesics; Animals; Benzodiazepines; Binding, Competitive; Brain; Cerebral Cortex; Computer Graphics; Conserved Sequence; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Humans; Ligands; Mice; Models, Molecular; Molecular Sequence Data; Molecular Structure; Pancreas; Protein Conformation; Radioligand Assay; Rats; Receptors, Cholecystokinin; Receptors, Opioid, kappa; Sequence Homology, Amino Acid; Sincalide; Structure-Activity Relationship | 1996 |
Identification of the three-dimensional pharmacophore of kappa-opioid receptor agonists.
Topics: Models, Chemical; Models, Molecular; Receptors, Opioid, kappa | 2010 |
Different motor actions of dynorphins and nonpeptide kappa opioid receptor agonists in the isolated rat colon.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Antihypertensive Agents; Benzeneacetamides; Benzodiazepines; Benzomorphans; Colon; Diuretics; Dynorphins; Gastrointestinal Motility; In Vitro Techniques; Male; Muscle, Smooth; Naloxone; Narcotic Antagonists; Pressure; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa | 1990 |
Pharmacological activities of optically pure enantiomers of the kappa opioid agonist, U50,488, and its cis diastereomer: evidence for three kappa receptor subtypes.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Behavior, Animal; Benzeneacetamides; Benzodiazepines; Benzomorphans; Binding, Competitive; Brain Chemistry; Cyclazocine; Discrimination, Psychological; Ethylketocyclazocine; Female; Guinea Pigs; Macaca mulatta; Male; Membranes; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Stereoisomerism | 1989 |
Effect of mu- and kappa-opioid agonists on the electroconvulsive seizure threshold in mice and antagonism by naloxone and MR 2266.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzeneacetamides; Benzodiazepines; Benzomorphans; Electroshock; Fentanyl; Male; Mice; Morphinans; Morphine; Nalbuphine; Naloxone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Seizures | 1988 |
Differential antagonism of bremazocine- and U69,593-induced antinociception by quadazocine: further functional evidence of opioid kappa receptor multiplicity in the mouse.
Topics: Analgesics; Animals; Azocines; Benzeneacetamides; Benzodiazepines; Benzomorphans; Cyclohexanes; Dose-Response Relationship, Drug; Ethylketocyclazocine; Male; Mice; Mice, Inbred ICR; Narcotic Antagonists; Pyrroles; Pyrrolidines; Receptors, Opioid, kappa; Structure-Activity Relationship; Thiophenes | 1993 |
Opioid peptide receptor studies. 10. Nor-BNI differentially inhibits kappa receptor agonist-induced G-protein activation in the guinea pig caudate: further evidence of kappa receptor heterogeneity.
Topics: Animals; Benzeneacetamides; Benzodiazepines; Brain; Caudate Nucleus; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; In Vitro Techniques; Inhibitory Concentration 50; Naltrexone; Oligopeptides; Peptide Fragments; Peptides; Pyrrolidines; Rats; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Somatostatin | 1999 |