Page last updated: 2024-09-05

tau 284 and piperidines

tau 284 has been researched along with piperidines in 45 studies

Compound Research Comparison

Studies (tau 284)	Trials (tau 284)	Recent Studies (post-2010) (tau 284)	Studies (piperidines)	Trials (piperidines)	Recent Studies (post-2010) (piperidines)
52	18	21	40,235	5,221	14,545

Research

Studies (45)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	6 (13.33)	18.2507
2000's	12 (26.67)	29.6817
2010's	22 (48.89)	24.3611
2020's	5 (11.11)	2.80

Authors

Authors	Studies
Kikuchi, M; Murata, T; Narita, H; Saito, N; Sakai, A; Tsuzurahara, K; Yato, N	1
Kikkawa, S; Kikuchi, M; Narita, H; Saito, N; Sakai, A; Yato, N	1
Matsumoto, Y; Murata, T; Naito, K; Suzuki, T; Takata, I; Tsuzurahara, K	1
Aga, Y; Endo, T; Kato, M; Kita, J; Kudo, Y; Narita, H; Nishida, A	1
Ikezawa, K; Kaminuma, O; Kikkawa, H; Kikuchi, M; Naito, K; Ogawa, K	1
Inagaki, N; Koda, A; Nagai, H; Ueno, M	1
Iizuka, H; Ishida-Yamamoto, A; Takahashi, H	1
Fukuda, H; Kamikozawa, Y; Ohashi, R; Sugiura, M; Tamai, I; Yabuuchi, H	1
Andoh, T; Kuraishi, Y	1
Lamb, BT; Ryman, D	1
Ikeda, T; Kureyama, N; Moriyasu, S; Okamura, K; Yamamoto, K; Yamatodani, A	1
Kambe, N; Matsuda, H; Miyachi, Y; Nakamura, Y; Tanaka, A; Tanizaki, H	1
Duan, X; Funaki, Y; Ishikawa, Y; Itoh, M; Iwata, R; Kato, M; Miyake, M; Tashiro, M; Watanuki, S; Yanai, K	1
Fukui, H; Izumi, N; Mizuguchi, H; Ogino, S; Umehara, H	1
Kabashima, K; Kobayashi, M; Nakamura, M; Tokura, Y	1
Fujita, T; Gotoh, M; Hashiguchi, K; Okubo, K; Suematsu, K; Tang, H	1
Ikezawa, Z; Inomata, N; Tatewaki, S	1
Abelson, MB; Gomes, PJ; Gow, JA; McNamara, TR; Torkildsen, GL; Williams, JI	2
Atsumi, I; Fujii, A; Iemura, M; Kida, T; Sakai, O; Sakaki, H; Wada, T	1
Abelson, MB; Bergmann, MT; Gomes, PJ; Gow, JA; Macejko, TT; McNamara, TR; Williams, JI	1
Lyseng-Williamson, KA	1
Gow, JA; Klier, SM; McCue, SL; McNamara, TR; Salapatek, AM; Williams, JI	1
Funaki, Y; Kato, M; Okamura, N; Shibuya, K; Tashiro, M; Yanai, K; Yoshikawa, T; Zhang, D	1
Abelson, MB; Gomes, PJ; Gow, JA; Kennedy, KS; McNamara, TR; Torkildsen, GL; Williams, JI	1
Doi, R; Haga, T; Kawakami, T; Kimura, S; Kyoya, M; Nakagawa, K; Soma, Y	1
Fukuoka, M; Ikoma, A; Kabashima, K; Miyachi, Y; Tanizaki, H	1
Cho, KH; Choi, HG	1
Choi, YK; Chung, YH; Jeong, JH; Kang, DY; Kim, H; Kim, HR; Lee, SE; Lee, YS; Nam, YS	1
Kim, KA; Park, JY	1
Bielory, L; Duttachoudhury, S; McMunn, A	1
Hu, X; Liu, J; Shentu, J; Wu, G; Wu, L; Zhai, Y; Zheng, Y; Zhou, H; Zhu, M	1
Hyeon, JH; Kim, HS; Kim, JY; Kim, YJ; Kwack, SJ; Kwak, HM; Lee, BM; Lee, JD; Lim, DS; Lim, SK; Um, YM; Youn, YS	1
Anusha, S; Babu Rajeev, CP; Bender, A; Chandramohanadas, R; Chu, TT; Fuchs, JE; Mathai, J; Preiser, PR; Rangappa, KS; Shivananju, N; Sinha, A; Ximei, H	1
Ichimura, M; Izaki, H; Koyama, T; Okubo, K; Susuta, Y	1
Kanamitsu, K; Kusuhara, H; Nagaya, Y; Nozaki, Y; Sugiyama, Y	1
Carrillo-Martin, I; Dimov, V; Gonzalez-Estrada, A	1
Babu, M; Dudeja, I; Dudeja, L; Janakiraman, A; Sane, K	1
Han, C; Sun, L; Yu, J; Zhang, C; Zou, Q	1
Fordjuor, G; Kim, SI; Lee, JE; Lee, JH; Lee, JS; Park, CY	1
Bharatam, PV; Chakraborti, AK; Giri, S; Sahu, A; Singh, DK; Singh, S; Wani, AA	1
Cho, SH; Hong, SN; Jeong, JH; Kim, CH; Kim, DW; Kim, DY; Kim, HY; Kim, ST; Kim, SW; Kim, TH; Lee, KH; Mo, JH; Rhee, CS	1
Ayyappanavar, S; Gangasagara, SB; Jayanthi, CR; Kumar, K; Mittal, P; Preethi, B; Rathod, BLS; Sridhar, S	1
Huang, J; Li, F; Shao, L; Shi, G; Wang, X; Wu, K; Yan, J; Yang, L; Yin, X	1

Reviews

5 review(s) available for tau 284 and piperidines

Article	Year
Genetic and environmental modifiers of Alzheimer's disease phenotypes in the mouse. Current Alzheimer research, 2006, Volume: 3, Issue:5 Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Disease Models, Animal; Environment; Humans; Mice; Mice, Transgenic; Phenotype; Phosphorylation; Piperidines; Pyridines; tau Proteins	2006
Bepotastine (bepreve)--an ophthalmic H1-antihistamine. The Medical letter on drugs and therapeutics, 2010, Feb-08, Volume: 52, Issue:1331 Topics: Administration, Topical; Animals; Eye Diseases; Histamine H1 Antagonists; Humans; Ophthalmic Solutions; Piperidines; Pyridines; Randomized Controlled Trials as Topic	2010
Oral bepotastine: in allergic disorders. Drugs, 2010, Aug-20, Volume: 70, Issue:12 Topics: Administration, Oral; Anti-Allergic Agents; Histamine H1 Antagonists; Humans; Hypersensitivity; Piperidines; Pruritus; Pyridines; Rhinitis, Allergic, Perennial; Urticaria	2010
Non-clinical pharmacology, pharmacokinetics, and safety findings for the antihistamine bepotastine besilate. Current medical research and opinion, 2010, Volume: 26, Issue:10 Topics: Animals; Anti-Allergic Agents; Conjunctivitis, Allergic; Disease Models, Animal; Drug Evaluation, Preclinical; Histamine Antagonists; Humans; Mice; Piperidines; Pruritus; Pyridines; Rats	2010
Bepotastine besilate for the treatment of pruritus. Expert opinion on pharmacotherapy, 2013, Volume: 14, Issue:18 Topics: Administration, Cutaneous; Administration, Oral; Animals; Clinical Trials as Topic; Conjunctivitis, Allergic; Histamine H1 Antagonists; Humans; Piperidines; Pruritus; Pyridines; Rhinitis, Allergic; Rhinitis, Allergic, Perennial; Urticaria	2013

Trials

15 trial(s) available for tau 284 and piperidines

Article	Year
Effects of bepotastine, cetirizine, fexofenadine, and olopatadine on histamine-induced wheal-and flare-response, sedation, and psychomotor performance. Clinical and experimental dermatology, 2004, Volume: 29, Issue:5 Topics: Adult; Cetirizine; Cross-Over Studies; Dermatitis, Atopic; Dibenzoxepins; Double-Blind Method; Female; Histamine; Histamine H1 Antagonists; Humans; Iontophoresis; Male; Olopatadine Hydrochloride; Piperidines; Psychomotor Performance; Pyridines; Sleep Stages; Terfenadine	2004
Brain histamine H1 receptor occupancy of orally administered antihistamines, bepotastine and diphenhydramine, measured by PET with 11C-doxepin. British journal of clinical pharmacology, 2008, Volume: 65, Issue:6 Topics: Administration, Oral; Adult; Brain; Carbon Radioisotopes; Diphenhydramine; Doxepin; Histamine H1 Antagonists; Histamine H1 Antagonists, Non-Sedating; Humans; Male; Piperidines; Positron-Emission Tomography; Pyridines; Receptors, Histamine H1; Sleep Stages	2008
Bepotastine besilate OD tablets suppress nasal symptoms caused by Japanese cedar pollen exposure in an artificial exposure chamber (OHIO Chamber). Expert opinion on pharmacotherapy, 2009, Volume: 10, Issue:4 Topics: Administration, Oral; Air Pollutants; Allergens; Anti-Allergic Agents; Atmosphere Exposure Chambers; Cognition; Female; Humans; Male; Nasal Lavage Fluid; Nasal Mucosa; Piperidines; Pollen; Pyridines; Rhinitis, Allergic, Seasonal; Single-Blind Method; Tablets	2009
Time to onset and duration of action of the antihistamine bepotastine besilate ophthalmic solutions 1.0% and 1.5% in allergic conjunctivitis: a phase III, single-center, prospective, randomized, double-masked, placebo-controlled, conjunctival allergen cha Clinical therapeutics, 2009, Volume: 31, Issue:9 Topics: Administration, Topical; Adolescent; Adult; Aged; Allergens; Anti-Allergic Agents; Child; Conjunctivitis, Allergic; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Male; Middle Aged; Ophthalmic Solutions; Piperidines; Prospective Studies; Pruritus; Pyridines; Severity of Illness Index; Time Factors; Treatment Outcome; Young Adult	2009
Multicenter clinical evaluation of bepotastine besilate ophthalmic solutions 1.0% and 1.5% to treat allergic conjunctivitis. American journal of ophthalmology, 2010, Volume: 150, Issue:1 Topics: Adolescent; Adult; Anti-Allergic Agents; Child; Conjunctiva; Conjunctivitis, Allergic; Double-Blind Method; Female; Humans; Hyperemia; Male; Middle Aged; Ophthalmic Solutions; Piperidines; Prospective Studies; Pyridines; Treatment Outcome; Visual Acuity	2010
Bepotastine besilate ophthalmic solution for the relief of nonocular symptoms provoked by conjunctival allergen challenge. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2010, Volume: 105, Issue:1 Topics: Adult; Allergens; Conjunctivitis, Allergic; Double-Blind Method; Female; Histamine Antagonists; Humans; Immunization; Male; Middle Aged; Nasal Obstruction; Ophthalmic Solutions; Piperidines; Pyridines	2010
Next-day residual sedative effect after nighttime administration of an over-the-counter antihistamine sleep aid, diphenhydramine, measured by positron emission tomography. Journal of clinical psychopharmacology, 2010, Volume: 30, Issue:6 Topics: Administration, Oral; Brain; Cross-Over Studies; Diphenhydramine; Double-Blind Method; Histamine H1 Antagonists; Humans; Hypnotics and Sedatives; Male; Nonprescription Drugs; Piperidines; Positron-Emission Tomography; Pyridines; Receptors, Histamine H1; Sleep Initiation and Maintenance Disorders; Young Adult	2010
Prolonged effectiveness of bepotastine besilate ophthalmic solution for the treatment of ocular symptoms of allergic conjunctivitis. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2011, Volume: 27, Issue:4 Topics: Adolescent; Adult; Aged; Anti-Allergic Agents; Child; Conjunctiva; Conjunctivitis, Allergic; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Hyperemia; Male; Middle Aged; Ophthalmic Solutions; Piperidines; Prospective Studies; Pruritus; Pyridines; Time Factors; Young Adult	2011
UPLC-MS/MS method for determination of bepotastine in human plasma. Journal of chromatographic science, 2014, Volume: 52, Issue:8 Topics: Administration, Oral; Chromatography, Liquid; Drug Stability; Humans; Male; Piperidines; Pyridines; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry	2014
Pharmacokinetic comparisons of bepotastine besilate and bepotastine salicylate in healthy subjects. Clinical drug investigation, 2013, Volume: 33, Issue:12 Topics: Adult; Area Under Curve; Cross-Over Studies; Healthy Volunteers; Humans; Male; Middle Aged; Piperidines; Pyridines; Salicylates; Single-Blind Method; Young Adult	2013
Comparative fasting bioavailability of 2 bepotastine formulations in healthy male Chinese volunteers: an open-label, randomized, single-dose, 2-way crossover study. Clinical therapeutics, 2014, Apr-01, Volume: 36, Issue:4 Topics: Adult; Area Under Curve; Asian People; Biological Availability; Chemistry, Pharmaceutical; China; Cross-Over Studies; Drugs, Generic; Fasting; Healthy Volunteers; Humans; Male; Piperidines; Pyridines; Tablets; Tandem Mass Spectrometry; Therapeutic Equivalency; United States; Young Adult	2014
Double-blind placebo-controlled study of bepotastine besilate in pediatric patients with perennial allergic rhinitis. Expert opinion on pharmacotherapy, 2015, Volume: 16, Issue:16 Topics: Adolescent; Child; Double-Blind Method; Histamine Antagonists; Humans; Piperidines; Pyridines; Rhinitis, Allergic, Perennial	2015
Observer-masked trial comparing efficacy of topical olopatadine (0.1%), bepotastine (1.5%), and alcaftadine (0.25%) in mild to moderate allergic conjunctivitis. Indian journal of ophthalmology, 2019, Volume: 67, Issue:9 Topics: Adolescent; Adult; Anti-Allergic Agents; Benzazepines; Child; Conjunctiva; Conjunctivitis, Allergic; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Histamine H1 Antagonists; Humans; Imidazoles; Male; Olopatadine Hydrochloride; Ophthalmic Solutions; Piperidines; Prospective Studies; Pyridines; Single-Blind Method; Treatment Outcome; Young Adult	2019
Double-Blind Placebo-Controlled Trial of Bepotastine Salicylate in Patients With Allergic Rhinitis. The Laryngoscope, 2021, Volume: 131, Issue:3 Topics: Administration, Oral; Adult; Aged; Delayed-Action Preparations; Double-Blind Method; Drug Administration Schedule; Drug Combinations; Female; Humans; Male; Middle Aged; Piperidines; Pyridines; Rhinitis, Allergic; Salicylates; Sino-Nasal Outcome Test; Treatment Outcome; Young Adult	2021
Comparative analysis of safety and efficacy of Alcaftadine 0.25%, Olopatadine hydrochloride 0.2% and Bepotastine besilate 1.5% in allergic conjunctivitis. Indian journal of ophthalmology, 2021, Volume: 69, Issue:2 Topics: Anti-Allergic Agents; Benzazepines; Conjunctivitis, Allergic; Double-Blind Method; Humans; Imidazoles; Olopatadine Hydrochloride; Ophthalmic Solutions; Piperidines; Prospective Studies; Pyridines; Treatment Outcome	2021

Other Studies

25 other study(ies) available for tau 284 and piperidines

Article	Year
[Anti-allergic activity of betotastine besilate (TAU-284), a new anti-allergic drug]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1997, Volume: 110, Issue:1 Topics: Administration, Oral; Animals; Anti-Allergic Agents; Arachidonic Acids; Capillary Permeability; Cells, Cultured; Depression, Chemical; Dose-Response Relationship, Drug; Histamine Antagonists; Histamine Release; Male; Mast Cells; Passive Cutaneous Anaphylaxis; Piperidines; Pyridines; Rats; Rats, Sprague-Dawley	1997
Inhibitory effect of betotastine besilate on antigen-induced airway eosinophil infiltration and peripheral blood eosinophilia in mice. Arzneimittel-Forschung, 1997, Volume: 47, Issue:8 Topics: Animals; Anti-Allergic Agents; Blood Cell Count; Bronchoalveolar Lavage Fluid; Eosinophilia; Eosinophils; Leukocyte Count; Lung; Male; Mice; Ovalbumin; Piperidines; Pyridines; Respiratory Hypersensitivity	1997
[Effect of betotastine besilate (TAU-284), a novel anti-allergic agent, on experimental allergic rhinitis]. Arerugi = [Allergy], 1997, Volume: 46, Issue:7 Topics: Airway Resistance; Animals; Anti-Allergic Agents; Capillary Permeability; Disease Models, Animal; Guinea Pigs; Humans; Infant; Male; Piperidines; Pyridines; Rats; Rats, Sprague-Dawley; Rhinitis, Allergic, Perennial	1997
Pharmacokinetic and pharmacodynamic evaluation of central effect of the novel antiallergic agent betotastine besilate. Arzneimittel-Forschung, 1997, Volume: 47, Issue:10 Topics: Animals; Anti-Allergic Agents; Arousal; Cats; Central Nervous System; CHO Cells; Chromatography, High Pressure Liquid; Cricetinae; Female; Guinea Pigs; In Vitro Techniques; Male; Mice; Motor Activity; Piperidines; Pyridines; Rats; Rats, Wistar; Receptors, Drug; Sleep	1997
A novel anti-allergic drug, betotastine besilate, suppresses interleukin-5 production by human peripheral blood mononuclear cells. Biological & pharmaceutical bulletin, 1998, Volume: 21, Issue:4 Topics: Adult; Anti-Allergic Agents; Cell Division; Cells, Cultured; Humans; Indicators and Reagents; Interleukin-5; Ketotifen; Male; Middle Aged; Monocytes; Piperidines; Pyridines	1998
Antiallergic action of betotastine besilate (TAU-284) in animal models: A comparison with ketotifen. Pharmacology, 1998, Volume: 57, Issue:4 Topics: Animals; Anti-Allergic Agents; Asthma; Bronchoconstriction; Disease Models, Animal; Eosinophilia; Eosinophils; Female; Guinea Pigs; Histamine H1 Antagonists; Hypersensitivity; Ketotifen; Male; Passive Cutaneous Anaphylaxis; Piperidines; Platelet Activating Factor; Pyridines; Rats; Rats, Wistar	1998
Effect of P-glycoprotein on intestinal absorption and brain penetration of antiallergic agent bepotastine besilate. Drug metabolism and disposition: the biological fate of chemicals, 2006, Volume: 34, Issue:5 Topics: Adenosine Triphosphatases; Animals; Anti-Allergic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Autoradiography; Biological Transport, Active; Brain; Chromatography, Liquid; Intestinal Absorption; Kinetics; LLC-PK1 Cells; Male; Mass Spectrometry; Mice; Mice, Knockout; Piperidines; Pyridines; Rats; Rats, Sprague-Dawley; Stimulation, Chemical; Swine; Terfenadine; Verapamil	2006
Suppression by bepotastine besilate of substance P-induced itch-associated responses through the inhibition of the leukotriene B4 action in mice. European journal of pharmacology, 2006, Oct-10, Volume: 547, Issue:1-3 Topics: Administration, Oral; Animals; Behavior, Animal; Calcium; Dose-Response Relationship, Drug; Ganglia, Spinal; Histamine H1 Antagonists; Leukotriene B4; Male; Mice; Mice, Inbred ICR; Neurons; Neutrophils; Piperidines; Pruritus; Pyridines; Skin; Substance P	2006
Involvement of histamine released from mast cells in acute radiation dermatitis in mice. Journal of pharmacological sciences, 2007, Volume: 104, Issue:2 Topics: Acute Disease; Animals; Chlorpheniramine; Dose-Response Relationship, Drug; Edema; Erythema; Hair Removal; Histamine; Histamine H1 Antagonists; Histamine Release; Male; Mast Cells; Mice; Mice, Inbred C57BL; Piperidines; Pyridines; Radiodermatitis; Receptors, Histamine H1	2007
Oral administration of bepotastine besilate suppressed scratching behavior of atopic dermatitis model NC/Nga mice. International archives of allergy and immunology, 2008, Volume: 145, Issue:4 Topics: Administration, Oral; Animals; Antipruritics; Behavior, Animal; Dermatitis, Atopic; Disease Models, Animal; Male; Mice; Mice, Inbred BALB C; Mice, Inbred Strains; p-Methoxy-N-methylphenethylamine; Piperidines; Pruritus; Pyridines	2008
Analysis of disease-dependent sedative profiles of H(1)-antihistamines by large-scale surveillance using the visual analog scale. Methods and findings in experimental and clinical pharmacology, 2008, Volume: 30, Issue:3 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Asthma; Butyrophenones; Cetirizine; Child; Chlorpheniramine; Dermatitis, Atopic; Dibenzazepines; Dibenzoxepins; Female; Histamine H1 Antagonists; Histamine H1 Antagonists, Non-Sedating; Humans; Imidazoles; Japan; Male; Middle Aged; Olopatadine Hydrochloride; Pain Measurement; Piperidines; Population Surveillance; Psychomotor Performance; Pyridines; Quality of Life; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal; Sleep Stages; Surveys and Questionnaires; Terfenadine; Urticaria	2008
Downmodulatory effects of the antihistaminic drug bepotastine on cytokine/chemokine production and CD54 expression in human keratinocytes. Skin pharmacology and physiology, 2009, Volume: 22, Issue:1 Topics: Cells, Cultured; Chemokine CCL17; Chemokine CXCL10; Chemokines; Cytokines; Dose-Response Relationship, Drug; Down-Regulation; Histamine H1 Antagonists, Non-Sedating; Humans; Intercellular Adhesion Molecule-1; Interleukin-1alpha; Keratinocytes; Piperidines; Pyridines	2009
Multiple H1-antihistamine-induced urticaria. The Journal of dermatology, 2009, Volume: 36, Issue:4 Topics: Administration, Oral; Adult; Drug Eruptions; Female; Histamine; Histamine H1 Antagonists; Humans; Immunologic Tests; Leukotriene B4; Loratadine; Piperidines; Pyridines; Skin Tests; Terfenadine; Urticaria	2009
Bepotastine besilate, a highly selective histamine H(1) receptor antagonist, suppresses vascular hyperpermeability and eosinophil recruitment in in vitro and in vivo experimental allergic conjunctivitis models. Experimental eye research, 2010, Volume: 91, Issue:1 Topics: Animals; Capillary Permeability; Cells, Cultured; Chemotaxis, Leukocyte; Conjunctiva; Conjunctivitis, Allergic; Disease Models, Animal; Dose-Response Relationship, Drug; Eosinophils; Guinea Pigs; Histamine; Histamine H1 Antagonists; Histamine Release; Leukotriene B4; Male; Mast Cells; Ovalbumin; Peritoneal Cavity; Piperidines; Platelet Activating Factor; Pyridines; Rats; Rats, Wistar	2010
Health-related quality of life assessed by the effect of bepotastine besilate in patients with pruritus: importance of emotions score in atopic dermatitis. The Journal of dermatology, 2012, Volume: 39, Issue:6 Topics: Adolescent; Adult; Aged; Dermatitis, Atopic; Emotions; Female; Histamine H1 Antagonists; Humans; Male; Middle Aged; Piperidines; Pruritus; Pyridines; Quality of Life; Surveys and Questionnaires; Young Adult	2012
Effects of bepotastine and fexofenadine on histamine-induced flare, wheal and itch. International archives of allergy and immunology, 2012, Volume: 158, Issue:2 Topics: Adult; Female; Histamine; Histamine H1 Antagonists, Non-Sedating; Humans; Male; Piperidines; Pruritus; Pyridines; Skin; Terfenadine; Urticaria	2012
Development of novel bepotastine salicylate salt bioequivalent to the commercial bepotastine besilate in beagle dogs. Drug development and industrial pharmacy, 2013, Volume: 39, Issue:6 Topics: Animals; Cross-Over Studies; Dogs; Drug Discovery; Male; Piperidines; Pyridines; Salicylic Acid; Therapeutic Equivalency	2013
Comparative efficacy and bioequivalence of novel h1-antihistamine bepotastine salts (nicotinate and salicylate). Journal of toxicology and environmental health. Part A, 2014, Volume: 77, Issue:22-24 Topics: Animals; Chemical Phenomena; Chromatography, Liquid; Dogs; Female; Guinea Pigs; Histamine Antagonists; Hydrogen-Ion Concentration; Male; Niacin; Piperidines; Pyridines; Rats; Rats, Sprague-Dawley; Salicylates; Tablets; Tandem Mass Spectrometry; Therapeutic Equivalency	2014
Synthesis, characterization and in vitro evaluation of novel enantiomerically-pure sulphonamide antimalarials. Organic & biomolecular chemistry, 2015, Nov-21, Volume: 13, Issue:43 Topics: Acyltransferases; Antimalarials; Humans; Malaria, Falciparum; Models, Molecular; Piperidines; Plasmodium falciparum; Pyridines; Sulfonamides	2015
Quantitative prediction of histamine H1 receptor occupancy by the sedative and non-sedative antagonists in the human central nervous system based on systemic exposure and preclinical data. Drug metabolism and pharmacokinetics, 2017, Volume: 32, Issue:2 Topics: Animals; Brain; Central Nervous System; Diphenhydramine; Histamine H1 Antagonists; Humans; Ketotifen; Macaca fascicularis; Male; Mice; Mice, Inbred Strains; Olopatadine Hydrochloride; Piperidines; Positron-Emission Tomography; Pyridines; Receptors, Histamine H1; Time Factors	2017
Bepotastine besilate for the treatment of perennial allergic rhinitis. Expert opinion on pharmacotherapy, 2018, Volume: 19, Issue:15 Topics: Humans; Piperidines; Pyridines; Rhinitis, Allergic, Perennial	2018
Identification, Characterization and HPLC Quantification of Process-Related Impurities in Bepotastine Besilate Bulk Drug. Drug research, 2020, Volume: 70, Issue:1 Topics: Anti-Allergic Agents; Chromatography, High Pressure Liquid; Drug Compounding; Drug Contamination; Limit of Detection; Magnetic Resonance Spectroscopy; Piperidines; Pyridines; Tandem Mass Spectrometry	2020
Comparison of cytotoxicities and anti-allergic effects of topical ocular dual-action anti-allergic agents. BMC ophthalmology, 2019, Nov-08, Volume: 19, Issue:1 Topics: Anti-Allergic Agents; Benzazepines; Cell Survival; Cells, Cultured; Conjunctiva; Cornea; Epithelial Cells; Humans; Imidazoles; Olopatadine Hydrochloride; Piperidines; Pyridines	2019
Characterization of Photodegradation Products of Bepotastine Besilate and In Silico Evaluation of Their Physicochemical, Absorption, Distribution, Metabolism, Excretion and Toxicity Properties. Journal of pharmaceutical sciences, 2020, Volume: 109, Issue:6 Topics: Computer Simulation; Conjunctivitis, Allergic; Gas Chromatography-Mass Spectrometry; Humans; Photolysis; Piperidines; Pyridines	2020
Efficient synthesis of bepotastine and cloperastine intermediates using engineered alcohol dehydrogenase with a hydrophobic pocket. Applied microbiology and biotechnology, 2021, Volume: 105, Issue:14-15 Topics: Alcohol Dehydrogenase; Biocatalysis; Hydrophobic and Hydrophilic Interactions; Kinetics; Piperidines; Pyridines; Stereoisomerism	2021

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