Page last updated: 2024-09-05

tak 779 and vicriviroc

tak 779 has been researched along with vicriviroc in 7 studies

Compound Research Comparison

Studies
(tak 779)
Trials
(tak 779)
Recent Studies (post-2010)
(tak 779)
Studies
(vicriviroc)
Trials
(vicriviroc)
Recent Studies (post-2010) (vicriviroc)
1181351012036

Protein Interaction Comparison

ProteinTaxonomytak 779 (IC50)vicriviroc (IC50)
C-C chemokine receptor type 5Homo sapiens (human)0.0016
C-C chemokine receptor type 5Mus musculus (house mouse)0.0009

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (28.57)29.6817
2010's5 (71.43)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Fukushima, D; Hisaichi, K; Jenkinson, S; Kazmierski, WM; Maeda, K; Matsunaga, N; Minamoto, C; Mitsuya, H; Nakai, H; Nishiyama, T; Nishizawa, R; Sagawa, K; Shibayama, S; Tada, H; Takaoka, Y1
Fukushima, D; Hisaichi, K; Maeda, K; Minamoto, C; Mitsuya, H; Murota, M; Nakai, H; Nishiyama, T; Nishizawa, R; Sagawa, K; Shibayama, S; Tada, H; Takaoka, Y1
Horuk, R; Pease, J1
Dioszegi, M; Ji, C; Kondru, R; Mirzadegan, T; Rotstein, D; Sankuratri, S; Zhang, J1
Arenzana-Seisdedos, F1
Henrich, TJ; Konstantinidis, I; Kuritzkes, DR; Leopold, KE; Lewine, NR; Sagar, M; Tsibris, AM1
Coakley, E; Greaves, W; Gulick, RM; Henrich, TJ; Hu, Z; Kuritzkes, DR; Lee, SH; Putcharoen, O; Tsibris, AM; Vanichanan, J1

Reviews

1 review(s) available for tak 779 and vicriviroc

ArticleYear
[Viral entry as therapeutic target. Current situation of entry inhibitors].
    Enfermedades infecciosas y microbiologia clinica, 2008, Volume: 26 Suppl 11

    Topics: Adult; Amides; Benzoates; CCR5 Receptor Antagonists; CD4 Antigens; Chemokines, CC; Chemokines, CXC; Clinical Trials as Topic; Cyclohexanes; Diketopiperazines; Drug Design; env Gene Products, Human Immunodeficiency Virus; HIV; HIV Fusion Inhibitors; HIV Infections; Humans; Maraviroc; Membrane Fusion; Models, Molecular; Piperazines; Pyrimidines; Quaternary Ammonium Compounds; Receptors, CCR5; Receptors, CXCR4; Spiro Compounds; Structure-Activity Relationship; Triazoles; Virus Attachment; Virus Internalization

2008

Trials

1 trial(s) available for tak 779 and vicriviroc

ArticleYear
HIV-1 clinical isolates resistant to CCR5 antagonists exhibit delayed entry kinetics that are corrected in the presence of drug.
    Journal of virology, 2012, Volume: 86, Issue:2

    Topics: Amides; Anti-HIV Agents; CCR5 Receptor Antagonists; Drug Resistance, Viral; HIV Envelope Protein gp120; HIV Infections; HIV-1; Humans; Kinetics; Molecular Sequence Data; Mutation; Piperazines; Pyrimidines; Quaternary Ammonium Compounds; Virus Internalization

2012

Other Studies

5 other study(ies) available for tak 779 and vicriviroc

ArticleYear
Spirodiketopiperazine-based CCR5 antagonist: discovery of an antiretroviral drug candidate.
    Bioorganic & medicinal chemistry letters, 2011, Feb-15, Volume: 21, Issue:4

    Topics: Administration, Oral; Animals; Anti-HIV Agents; CCR5 Receptor Antagonists; Cell Line, Tumor; Diketopiperazines; Drug Evaluation, Preclinical; HIV Core Protein p24; HIV-1; Humans; Microsomes, Liver; Rats; Receptors, CCR5; Spiro Compounds; Stereoisomerism

2011
Discovery of 4-[4-({(3R)-1-butyl-3-[(R)-cyclohexyl(hydroxy)methyl]-2,5-dioxo-1,4,9-triazaspiro[5.5]undec-9-yl}methyl)phenoxy]benzoic acid hydrochloride: a highly potent orally available CCR5 selective antagonist.
    Bioorganic & medicinal chemistry, 2011, Jul-01, Volume: 19, Issue:13

    Topics: Administration, Oral; Animals; Anti-HIV Agents; Benzoates; CCR5 Receptor Antagonists; Diketopiperazines; Dogs; Drug Evaluation, Preclinical; Guinea Pigs; Haplorhini; Humans; Rabbits; Rats; Receptors, CCR5; Structure-Activity Relationship

2011
Chemokine receptor antagonists.
    Journal of medicinal chemistry, 2012, Nov-26, Volume: 55, Issue:22

    Topics: Animals; Autoimmune Diseases; Humans; Receptors, Chemokine

2012
Molecular interactions of CCR5 with major classes of small-molecule anti-HIV CCR5 antagonists.
    Molecular pharmacology, 2008, Volume: 73, Issue:3

    Topics: Amides; Amino Acid Sequence; Animals; Anti-HIV Agents; Benzoates; Binding Sites; CCR5 Receptor Antagonists; CHO Cells; Cricetinae; Cricetulus; Cyclohexanes; Diketopiperazines; HIV Fusion Inhibitors; HIV-1; Humans; Hydrophobic and Hydrophilic Interactions; Inhibitory Concentration 50; Maraviroc; Membrane Fusion; Models, Molecular; Molecular Sequence Data; Molecular Structure; Mutagenesis, Site-Directed; Piperazines; Piperidines; Protein Structure, Secondary; Protein Structure, Tertiary; Pyrimidines; Quaternary Ammonium Compounds; Radioligand Assay; Receptors, CCR5; Sequence Homology, Amino Acid; Spiro Compounds; Static Electricity; Transfection; Triazoles

2008
Evolution of CCR5 antagonist resistance in an HIV-1 subtype C clinical isolate.
    Journal of acquired immune deficiency syndromes (1999), 2010, Volume: 55, Issue:4

    Topics: Amides; Amino Acid Sequence; Anti-HIV Agents; CCR5 Receptor Antagonists; Cyclohexanes; Drug Resistance, Viral; Evolution, Molecular; HIV Envelope Protein gp120; HIV Infections; HIV-1; Humans; Maraviroc; Microbial Sensitivity Tests; Molecular Sequence Data; Mutation; Peptide Fragments; Piperazines; Pyrimidines; Quaternary Ammonium Compounds; Receptors, CCR5; Triazoles

2010