tak 044 has been researched along with bq 123 in 15 studies
| Studies (tak 044) | Trials (tak 044) | Recent Studies (post-2010) (tak 044) | Studies (bq 123) | Trials (bq 123) | Recent Studies (post-2010) (bq 123) |
|---|---|---|---|---|---|
| 105 | 8 | 2 | 1,391 | 63 | 152 |
| Protein | Taxonomy | tak 044 (IC50) | bq 123 (IC50) |
|---|---|---|---|
| Endothelin-1 receptor | Homo sapiens (human) | 0.017 | |
| Endothelin-1 receptor | Rattus norvegicus (Norway rat) | 0.014 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (46.67) | 18.2507 |
| 2000's | 7 (46.67) | 29.6817 |
| 2010's | 1 (6.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Berens, KL; Blok, N; Bourgoyne, AR; Brock, TA; Bui, H; Decker, ER; Dixon, RA; Holland, GW; Knowles, V; Wang, J; Wu, C; You, TJ | 1 |
| Chatani, F; Eguchi, S; Hirata, Y; Marumo, F; Tsujino, M; Watanabe, T | 1 |
| Awane, Y; Fujino, M; Ikeda, S; Kusumoto, K; Wakimasu, M; Watanabe, T | 1 |
| Fujino, M; Fujiwara, A; Ikeda, S; Kusumoto, K; Watanabe, T | 1 |
| Awane-Igata, Y; Ikeda, S; Watanabe, T | 1 |
| Love, MP; McMurray, JJ | 1 |
| Gray, GA; Mickley, EJ; Webb, DJ | 1 |
| Endoh, M; Yang, HT; Zhu, Y | 1 |
| Hirata, Y; Marumo, F; Shichiri, M; Yokokura, M | 1 |
| Hirata, Y; Ishimaru, S; Mineshita, S; Shichiri, M | 1 |
| Hirata, Y; Ishimaru, S | 1 |
| Goto, K | 2 |
| Hirata, Y; Sugiyama, T | 1 |
| Briyal, S; Gulati, A; Philip, T | 1 |
3 review(s) available for tak 044 and bq 123
| Article | Year |
|---|---|
[Discovery of endothelin and its significance].
Topics: Amino Acid Sequence; Animals; Azepines; Cardiovascular Diseases; Drug Design; Endothelin Receptor Antagonists; Endothelin-1; Endothelins; Humans; Indans; Indoles; Molecular Sequence Data; Peptides, Cyclic; Pyrimidines; Receptors, Endothelin; Sulfonamides; Vasoconstriction | 2004 |
[Endothelin-1 and arteriosclerosis].
Topics: Animals; Arteriosclerosis; Cell Division; Dansyl Compounds; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin-1; Humans; Muscle, Smooth, Vascular; Neovascularization, Pathologic; Peptides, Cyclic; Receptor, Endothelin A; Receptor, Endothelin B; Vasoconstriction | 2004 |
[Prospects for endothelin-related drugs].
Topics: Animals; Aspartic Acid Endopeptidases; Bosentan; Cardiovascular Diseases; Drug Design; Endothelin Receptor Antagonists; Endothelin-1; Endothelin-Converting Enzymes; Hemodynamics; Humans; Metalloendopeptidases; Organophosphonates; Peptides, Cyclic; Quinazolines; Receptors, Endothelin; Sulfonamides; Sulfonylurea Compounds; Tetracyclines; Tetrazoles | 2004 |
1 trial(s) available for tak 044 and bq 123
| Article | Year |
|---|---|
Discovery, modeling, and human pharmacokinetics of N-(2-acetyl-4,6-dimethylphenyl)-3-(3,4-dimethylisoxazol-5-ylsulfamoyl)thiophene-2-carboxamide (TBC3711), a second generation, ETA selective, and orally bioavailable endothelin antagonist.
Topics: Administration, Oral; Animals; Antihypertensive Agents; Biological Availability; Dose-Response Relationship, Drug; Double-Blind Method; Endothelin A Receptor Antagonists; Humans; Isoxazoles; Ligands; Male; Models, Molecular; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Structure-Activity Relationship; Sulfones | 2004 |
11 other study(ies) available for tak 044 and bq 123
| Article | Year |
|---|---|
Nonselective ETA/ETB receptor antagonist blocks proliferation of rat vascular smooth muscle cells after balloon angioplasty.
Topics: Angioplasty, Balloon; Animals; Binding, Competitive; Cell Division; Cells, Cultured; Endothelin Receptor Antagonists; Endothelins; Iodine Radioisotopes; Male; Muscle, Smooth, Vascular; Peptides, Cyclic; Rats; Rats, Wistar | 1995 |
A new endothelin receptor antagonist, TAK-044, shows long-lasting inhibition of both ETA- and ETB-mediated blood pressure responses in rats.
Topics: Animals; Blood Pressure; Endothelin Receptor Antagonists; Endothelins; Kidney; Male; Peptides, Cyclic; Rats; Rats, Sprague-Dawley; Vasodilation | 1994 |
Pharmacological characterization of cardiovascular responses induced by endothelin-1 in the perfused rat heart.
Topics: Analysis of Variance; Animals; Blood Pressure; Cardiovascular System; Endothelin Receptor Antagonists; Endothelins; Heart; Male; Myocardial Contraction; Papillary Muscles; Peptides, Cyclic; Rats; Rats, Wistar; Receptor, Endothelin A; Vasoconstriction; Vasodilation | 1996 |
Inhibitory effects of TAK-044 on endothelin induced vasoconstriction in various canine arteries and porcine coronary arteries: a comparison with selective ETA and ETB receptor antagonists.
Topics: Animals; Arteries; Coronary Vessels; Dogs; Endothelin Receptor Antagonists; Endothelin-1; Endothelin-3; In Vitro Techniques; Male; Peptides, Cyclic; Receptors, Endothelin; Swine; Vasoconstriction; Vasoconstrictor Agents; Viper Venoms | 1997 |
Endothelin in heart failure: a promising therapeutic target?
Topics: Aspartic Acid Endopeptidases; Endothelin Receptor Antagonists; Endothelin-1; Endothelin-Converting Enzymes; Glycopeptides; Heart Failure; Humans; Metalloendopeptidases; Peptides, Cyclic; Protease Inhibitors | 1997 |
Activation of endothelin ETA receptors masks the constrictor role of endothelin ETB receptors in rat isolated small mesenteric arteries.
Topics: Animals; Endothelin-1; In Vitro Techniques; Male; Mesenteric Arteries; Oligopeptides; Peptides, Cyclic; Piperidines; Rats; Rats, Wistar; Receptor, Endothelin A; Receptor, Endothelin B; Receptors, Endothelin; Vasoconstriction; Viper Venoms | 1997 |
Negative chronotropic and inotropic effects of endothelin isopeptides in mammalian cardiac muscle.
Topics: Animals; Cyclic AMP; Dogs; Endothelin Receptor Antagonists; Endothelin-1; Endothelin-3; Heart Atria; Heart Rate; Heart Ventricles; In Vitro Techniques; Isoproterenol; Male; Mammals; Myocardial Contraction; Myocardium; Peptides, Cyclic; Pertussis Toxin; Prazosin; Rabbits; Receptor, Endothelin A; Receptor, Endothelin B; Virulence Factors, Bordetella | 1997 |
Endothelin-1 inhibits apoptosis of vascular smooth muscle cells induced by nitric oxide and serum deprivation via MAP kinase pathway.
Topics: Animals; Aorta; Apoptosis; Caspase 3; Caspases; Culture Media, Serum-Free; DNA Fragmentation; Endothelin Receptor Antagonists; Endothelin-1; Enzyme Activation; In Situ Nick-End Labeling; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Nitric Oxide; Oligopeptides; Peptides, Cyclic; Piperidines; Rats | 2000 |
Role of endothelin-1/endothelin receptor system in endotoxic shock rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Endothelin-1; Endothelins; Gene Expression; Heart Rate; Lipopolysaccharides; Male; Peptides, Cyclic; Protein Precursors; Rats; Rats, Wistar; Receptor, Endothelin A; Receptor, Endothelin B; Receptors, Endothelin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Shock, Septic; Survival Rate | 2001 |
Effects of endothelin receptor antagonists on endothelin-1 and inducible nitric oxide synthase genes in a rat endotoxic shock model.
Topics: Animals; Endothelin Receptor Antagonists; Endothelin-1; Gene Expression; Liver; Male; Models, Animal; Myocardium; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peptides, Cyclic; Rats; Rats, Wistar; Receptor, Endothelin A; Receptor, Endothelin B; Receptors, Endothelin; RNA, Messenger; Shock, Septic | 2002 |
Endothelin-A receptor antagonists prevent amyloid-β-induced increase in ETA receptor expression, oxidative stress, and cognitive impairment.
Topics: Amyloid beta-Peptides; Animals; Cognition Disorders; Dansyl Compounds; Endothelin A Receptor Antagonists; Gene Expression Regulation; Male; Oxidative Stress; Peptide Fragments; Peptides, Cyclic; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A | 2011 |