tafenoquine and atovaquone
tafenoquine has been researched along with atovaquone in 10 studies
Compound Research Comparison
| Studies (tafenoquine) | Trials (tafenoquine) | Recent Studies (post-2010) (tafenoquine) | Studies (atovaquone) | Trials (atovaquone) | Recent Studies (post-2010) (atovaquone) |
|---|---|---|---|---|---|
| 186 | 37 | 113 | 997 | 100 | 420 |
Protein Interaction Comparison
| Protein | Taxonomy | tafenoquine (IC50) | atovaquone (IC50) |
|---|---|---|---|
| Dihydroorotate dehydrogenase | Schistosoma mansoni | 0.431 | |
| Cytochrome b | Homo sapiens (human) | 2.835 | |
| Dihydroorotate dehydrogenase (quinone), mitochondrial | Homo sapiens (human) | 2.65 | |
| Dihydroorotate dehydrogenase (quinone), mitochondrial | Rattus norvegicus (Norway rat) | 0.7 | |
| Broad substrate specificity ATP-binding cassette transporter ABCG2 | Homo sapiens (human) | 0.23 |
Research
Studies (10)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (10.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (20.00) | 29.6817 |
| 2010's | 6 (60.00) | 24.3611 |
| 2020's | 1 (10.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
| Fidock, DA; Flannery, EL; Winzeler, EA | 1 |
| Iyer, PS; Kannan, M; Khan, FR; Raichurkar, AV | 1 |
| Gutteridge, WE | 1 |
| Jomaa, H; Ortmann, R; Schlitzer, M; Wiesner, J | 1 |
| Chambers, JA | 1 |
| Berman, J; DiTusa, C; Gettayacamin, M; Im-erbsin, R; Kozar, MP; Ohrt, C; Pybus, B; Sousa, J; Tungtaeng, A | 1 |
| Meltzer, E; Schwartz, E | 1 |
| Cilley, B; Krause, PJ; Nagami, EH; Norris, AM; Rogers, R; Ting, MH; Vannier, E | 1 |
Reviews
5 review(s) available for tafenoquine and atovaquone
| Article | Year |
|---|---|
Using genetic methods to define the targets of compounds with antimalarial activity.
Topics: Animals; Anopheles; Antimalarials; Drug Resistance; Genetic Association Studies; Genome, Protozoan; Humans; Malaria, Falciparum; Molecular Targeted Therapy; Plasmodium falciparum | 2013 |
Antimalarial drugs currently in development.
Topics: Aminoquinolines; Antimalarials; Artemisinins; Atovaquone; Chemical Phenomena; Chemistry; Drug Design; Drug Evaluation, Preclinical; Drug Resistance; Humans; Malaria; Naphthoquinones; Research; Sesquiterpenes | 1989 |
New antimalarial drugs.
Topics: Aminoquinolines; Animals; Antimalarials; Artemisinins; Artesunate; Atovaquone; Clinical Trials as Topic; Dapsone; Drug Combinations; Drug Design; Drug Resistance; Ethanolamines; Flavonoids; Fluorenes; Fosfomycin; Global Health; Humans; Lumefantrine; Malaria; Naphthoquinones; Naphthyridines; Plasmodium falciparum; Proguanil; Sesquiterpenes | 2003 |
Military aviators, special operations forces, and causal malaria prophylaxis.
Topics: Aminoquinolines; Antimalarials; Atovaquone; Aviation; Chloroquine; Doxycycline; Drug Combinations; Humans; Malaria; Mefloquine; Military Personnel; Naphthoquinones; Primaquine; Proguanil; United States | 2003 |
Expanded table: drugs for prophylaxis of malaria.
Topics: Aminoquinolines; Antimalarials; Atovaquone; Drug Combinations; Humans; Malaria; Pre-Exposure Prophylaxis; Statistics as Topic; Travel | 2019 |
Other Studies
5 other study(ies) available for tafenoquine and atovaquone
| Article | Year |
|---|---|
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
Synthesis and in vitro evaluation of novel 8-aminoquinoline-pyrazolopyrimidine hybrids as potent antimalarial agents.
Topics: Aminoquinolines; Antimalarials; Humans; Malaria, Falciparum; Molecular Docking Simulation; Parasitic Sensitivity Tests; Plasmodium falciparum; Pyrazoles; Pyrimidines; Structure-Activity Relationship | 2015 |
Causal prophylactic efficacy of primaquine, tafenoquine, and atovaquone-proguanil against Plasmodium cynomolgi in a rhesus monkey model.
Topics: Aminoquinolines; Animals; Antimalarials; Atovaquone; Disease Models, Animal; Drug Combinations; Macaca mulatta; Malaria; Parasitemia; Plasmodium cynomolgi; Primaquine; Proguanil | 2014 |
Atovaquone-proguanil chemoprophylaxis in the era of Tafenoquine.
Topics: Aminoquinolines; Antimalarials; Atovaquone; Chemoprevention; Drug Combinations; Drug Therapy, Combination; Humans; Malaria; Proguanil; Travel | 2019 |
Broad Antimicrobial Resistance in a Case of Relapsing Babesiosis Successfully Treated With Tafenoquine.
Topics: Aminoquinolines; Atovaquone; Babesiosis; Drug Resistance; Humans; Recurrence; RNA, Ribosomal, 23S | 2023 |