tabun and sarin
tabun has been researched along with sarin in 106 studies
Research
Studies (106)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 27 (25.47) | 18.7374 |
| 1990's | 19 (17.92) | 18.2507 |
| 2000's | 22 (20.75) | 29.6817 |
| 2010's | 31 (29.25) | 24.3611 |
| 2020's | 7 (6.60) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Dettbarn, WD; Gupta, RC | 1 |
| Boulet, CA; Clement, JG; Hansen, AS | 1 |
| Anderson, DR; Harris, LW; Koplovitz, I; Lennox, WJ; Stewart, JR | 1 |
| Maxwell, DM | 1 |
| Freeman, SE; Lau, WM; Szilagyi, M | 2 |
| Anderson, DR; Harris, LW; Lennox, WJ; Solana, RP; Talbot, BG | 1 |
| Bide, RW; Parker, D; Sawyer, TW; Thomas, N; Weiss, MT | 1 |
| Baraka, A | 1 |
| Eldefrawi, AT; Eldefrawi, ME; Silveira, CL | 1 |
| Dewey, WL; Tripathi, HL | 1 |
| Jokanović, M | 2 |
| Ho, IK; Hoskins, B; Liu, DD | 1 |
| Ho, IK; Hoskins, B; Liu, DD; Watanabe, HK | 1 |
| Boucher, LJ; Broomfield, CA; Fox-Talbot, MK; Lenz, DE; Little, JS; MacIver, B | 1 |
| Pantelić, D | 1 |
| Haraldsson, S; Lundberg, S; Marchner, H | 1 |
| Artursson, E; Bucht, G; Puu, G | 1 |
| Désiré, B; Saint-André, S | 2 |
| Sipponen, KB | 1 |
| Dawson, RM; Gray, PJ | 1 |
| Dulaney, MD; Fernando, JC; Ho, IK; Hoskins, B; Lim, DK; Liu, DD; Watanabe, HK | 1 |
| Beers, ET; Glenn, JF; Rickett, DL | 1 |
| Dulaney, MD; Ho, IK; Hoskins, B | 1 |
| Ho, IK; Hoskins, B; Sivam, SP | 1 |
| Beck, HC; Benschop, HP; Van den Berg, GR | 1 |
| Binenfeld, Z; Maksimović, M; Markov, V | 1 |
| Clement, JG; Filbert, M | 1 |
| Clement, JG | 1 |
| Blank, JA; Fricke, RF; Hobson, DW; Koplovitz, I; Olson, CT; Rockwood, GA; Scharf, BA | 1 |
| Koplovitz, I; Stewart, JR | 1 |
| Ashani, Y; Cohen, E; Grunwald, J; Marcus, D; Papier, Y; Raveh, L | 1 |
| Belkin, M; Solberg, Y | 1 |
| Holstege, CP; Kirk, M; Sidell, FR | 1 |
| Becker, G; Kawan, A; Szinicz, L | 1 |
| Munro, N | 1 |
| Cheng, TC; DeFrank, JJ; Rastogi, VK | 1 |
| Maxwell, DM; Sweeney, RE | 1 |
| Broomfield, CA; Platteborze, PL | 1 |
| McDonough, JH; Shih, TM | 1 |
| Hamazaki, T; Kataoka, M; Seto, Y; Takesako, H; Tsuge, K | 1 |
| Greenbaum, E; Rodriguez, M; Sanders, CA | 1 |
| Klein, R; Leikin, JB; Meislin, HW; Thomas, RG; Walter, FG | 1 |
| Amundson, DE; Devereaux, A; Lazarus, AA; Parrish, JS | 1 |
| Bueters, TJ; Danhof, M; Groen, B; IJzerman, AP; Van Helden, HP | 1 |
| KROP, S; KUNKEL, AM | 1 |
| BROWN, RV; KUNKEL, AM; SOMERS, LM; WILLS, JH | 1 |
| ADIE, PA | 1 |
| GRANT, GA; SCAIFE, JF; SHUSTER, J | 1 |
| HEILBRONN, E; TOLAGEN, B | 1 |
| Lobert, S; Martin, T | 1 |
| Kassa, J; Kuca, K | 1 |
| Niven, AS; Roop, SA | 1 |
| Newmark, J | 2 |
| Cabal, J; Kassa, J; Kuca, K | 1 |
| Kellar, KJ | 1 |
| Bajgar, J; Jun, D; Kuca, K | 1 |
| Dawson, RM; Kotsonis, SE; Pantelidis, S; Rose, HR | 1 |
| Hrobak, PK | 1 |
| Bahnson, BJ; Cerasoli, DM; Kirby, SD; Samanta, U; Srinivasan, P | 1 |
| Barakat, NH; Beck, JM; Cashman, JR; Gilley, CB; Hadad, CM; MacDonald, M; Okolotowicz, K; Vyas, S; Zhang, J; Zheng, X | 1 |
| Cashman, JR; Gilley, C; Lockridge, O; MacDonald, M; Nachon, F; Schopfer, LM; Zhang, J | 1 |
| Dale, TJ; Rebek, J | 1 |
| Estour, F; Lafont, O; Le Provost, R; Müller, S; Reiter, G; Tenberken, O; Thiermann, H; Wille, T; Worek, F | 1 |
| Aurbek, N; Herkert, NM; Koller, M; Thiermann, H; Worek, F | 1 |
| Noort, D; Trap, HC; van der Meer, JA; van der Schans, MJ | 1 |
| Patel, H | 1 |
| Hamilton, MG; Lundy, PM; Mikler, J; Sawyer, TW | 1 |
| Bird, M; Chad, JE; Green, AC; Price, M; Tattersall, JE; Timperley, CM; Turner, SR | 1 |
| Bumm, R; Friess, H; Gerhardus, J; Langer, P; Mihaljevic, AL; Niessen, KV; Seeger, T; Thiermann, H; Worek, F | 1 |
| Alamneh, Y; Biggemann, L; Costante, M; Doctor, BP; Garcia, G; Nambiar, MP; Nigam, S; Short, R; Soojhawon, I; Valiyaveettil, M | 1 |
| Kuca, K; Musilek, K; Thiermann, H; von der Wellen, J; Worek, F | 1 |
| Koller, M; Thiermann, H; Wille, T; Worek, F | 2 |
| Amitai, G; Barry Sharpless, K; Berend, S; Fokin, VV; Garcia, E; Kovarik, Z; Radić, Z; Sit, RK; Taylor, P; Zhang, L | 1 |
| Cerasoli, DM; Chilukuri, N; Harrison, J; Hodgins, SM; Kasten, SA; Oliver, ZP; Otto, TC; Reeves, TE; Rezk, P | 1 |
| Bahnson, BJ; Cerasoli, DM; Kirby, SD; Norris, JR; Richard Smith, J | 1 |
| Babu, UM; Condon, P; Mendez, A; Sambursky, R; VanDine, R | 1 |
| Graichen, AM; Vachet, RW | 1 |
| Thiermann, H; Wille, T; Worek, F | 1 |
| Li, D; Li, J; Liu, X; Marriott, PJ; Rose, G | 1 |
| Ringer, JM | 1 |
| Esposito, EX; Madura, JD; Stouch, TR; Wymore, T | 1 |
| Barba-Bon, A; Costero, AM; Gil, S; Martínez-Máñez, R; Sancenón, F | 1 |
| Cerasoli, DM; Dephillipo, T; Jones, JL; Kasten, SA; Zulli, S | 1 |
| Ikeda, T; Kondo, T; Kurimata, N; Nagashima, H; Nagoya, T; Seto, Y; Unoke, S | 1 |
| Kanamori-Kataoka, M; Seto, Y | 1 |
| Płusa, T; Sokołowski, R | 1 |
| Caetano, MS; da Cunha, EF; de Castro, AA; Mancini, DT; Ramalho, TC; Rocha, EP; Silva, TC | 1 |
| Cadieux, CL; Cerasoli, D; Koenig, JA; Koh, J; McDonough, J; Shih, TM; Wang, H; Zhang, Y | 1 |
| Biyikal, M; Climent, E; Costero, AM; Dropa, T; Gawlitza, K; Martínez-Máñez, R; Rurack, K; Urban, M | 1 |
| C C França, T; Cuya, T; da Silva, JAV; Gonçalves, ADS; Kuca, K; Ramalho, TC | 1 |
| Gupta, AK; Kumar, V; Rana, H; Rao, VK; Raviraju, G | 1 |
| Box, K; Ceckova, M; Dolezal, R; Gorecki, L; Hepnarova, V; Hrabinova, M; Jankockova, J; Jost, P; Jun, D; Kobrlova, T; Korabecny, J; Kuca, K; Malinak, D; Musilek, K; Nepovimova, E; Nguyen, TD; Outhwaite, B; Pavek, P; Pham, NL; Psotka, M; Sorf, A; Soukup, O | 1 |
| Bai, X; Du, M; Gong, A; Huo, B; Lai, Y; Li, M; Shen, A; Yang, Y | 1 |
| Kalisiak, J; Kovarik, Z; Maček Hrvat, N; Radić, Z; Sharpless, KB; Šinko, G; Taylor, P | 1 |
| Brazzolotto, X; Knežević, A; Kovarik, Z; Maraković, N; Rončević, I; Šinko, G | 1 |
| Bird, M; Green, AC; Kassa, J; Tattersall, JEH; Timperley, CM | 1 |
| Hughes, GT; Kelly, JT; Malloy, TA; Piatkowski, T; Qualley, A; Rubenstein, MH | 1 |
| Bernal, K; Brazzolotto, X; Bzdrenga, J; Chantegreil, F; Nachon, F; Trenet, E | 1 |
| Bajda, M; Jończyk, J; Jung, YS; Kukułowicz, J; Malawska, B; Musilek, K; Łątka, K | 1 |
| Leif, RN; Valdez, CA | 1 |
Reviews
13 review(s) available for tabun and sarin
| Article | Year |
|---|---|
Chemical warfare--the nerve gases.
Topics: Antidotes; Chemical Warfare Agents; Gas Poisoning; Humans; Organophosphate Poisoning; Organophosphates; Protective Clothing; Sarin; Soman | 1991 |
The role of excitotoxicity in organophosphorous nerve agents central poisoning.
Topics: Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Convulsants; Excitatory Amino Acid Antagonists; Humans; Neurons; Organophosphate Poisoning; Organophosphates; Organothiophosphorus Compounds; Receptors, N-Methyl-D-Aspartate; Sarin; Seizures; Soman; Synaptic Transmission | 1997 |
Chemical warfare. Nerve agent poisoning.
Topics: Animals; Chemical Warfare Agents; Cholinesterase Inhibitors; Decontamination; Disaster Planning; Emergency Medical Services; Humans; Nervous System Diseases; Organophosphate Poisoning; Organophosphates; Organothiophosphorus Compounds; Sarin; Soman | 1997 |
Toxicity of the organophosphate chemical warfare agents GA, GB, and VX: implications for public protection.
Topics: Animals; Chemical Warfare Agents; Cholinesterase Inhibitors; Environmental Pollutants; Humans; Lethal Dose 50; Organophosphates; Organothiophosphorus Compounds; Sarin | 1994 |
Alteromonas prolidase for organophosphorus G-agent decontamination.
Topics: Aryldialkylphosphatase; Chemical Warfare Agents; Decontamination; Dipeptidases; Esterases; Gram-Negative Aerobic Bacteria; Organophosphates; Organophosphorus Compounds; Sarin; Soman | 1999 |
A review of nerve agent exposure for the critical care physician.
Topics: Antidotes; Chemical Warfare Agents; Cholinesterase Inhibitors; Decontamination; Humans; Nervous System; Organophosphate Poisoning; Organophosphates; Organothiophosphorus Compounds; Sarin; Soman | 2002 |
Vesicants and nerve agents in chemical warfare. Decontamination and treatment strategies for a changed world.
Topics: Antidotes; Arsenicals; Chemical Warfare; Chemical Warfare Agents; Cholinesterase Inhibitors; Decontamination; Humans; Information Services; Internet; Irritants; Mustard Gas; Organophosphates; Organothiophosphorus Compounds; Primary Prevention; Protective Clothing; Sarin; Soman | 2002 |
Chemical warfare. Toxicity of nerve agents.
Topics: Antidotes; Chemical Warfare; Chemical Warfare Agents; Cholinesterase Inhibitors; Decontamination; Humans; Nervous System; Organophosphates; Organothiophosphorus Compounds; Sarin | 2003 |
Inhalational exposure to nerve agents.
Topics: Chemical Warfare Agents; Disaster Planning; Humans; Lung Diseases; Lung Injury; Organophosphates; Organothiophosphorus Compounds; Sarin; Soman; United States | 2004 |
Therapy for nerve agent poisoning.
Topics: Antidotes; Atropine; Chemical Warfare Agents; Humans; Neurotoxicity Syndromes; Neurotoxins; Organophosphate Poisoning; Organophosphates; Organothiophosphorus Compounds; Pralidoxime Compounds; Pyridostigmine Bromide; Sarin; Soman | 2004 |
Comparative protective effects of HI-6 and MMB-4 against organophosphorous nerve agent poisoning.
Topics: Antidotes; Chemical Warfare Agents; Humans; Organophosphate Poisoning; Organophosphates; Organophosphorus Compounds; Oximes; Pyridinium Compounds; Sarin; Soman | 2011 |
[Today's threat of use of organophosphorus compounds].
Topics: Chemical Warfare Agents; Cholinesterase Inhibitors; Environmental Exposure; Humans; Organophosphate Poisoning; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Sarin; Seizures; Soman | 2015 |
Analysis of Organophosphorus-Based Nerve Agent Degradation Products by Gas Chromatography-Mass Spectrometry (GC-MS): Current Derivatization Reactions in the Analytical Chemist's Toolbox.
Topics: Alkylation; Fluorobenzenes; Gas Chromatography-Mass Spectrometry; Humans; Hydrolysis; Methylation; Nerve Agents; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Sarin; Soman | 2021 |
Other Studies
93 other study(ies) available for tabun and sarin
| Article | Year |
|---|---|
Potential of memantine, D-tubocurarine, and atropine in preventing acute toxic myopathy induced by organophosphate nerve agents: soman, sarin, tabun and VX.
Topics: Acetylcholinesterase; Acute Disease; Animals; Atropine; Cholinesterase Inhibitors; Male; Memantine; Muscular Diseases; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Rats; Rats, Sprague-Dawley; Sarin; Soman; Tubocurarine | 1992 |
Efficacy of HLö-7 and pyrimidoxime as antidotes of nerve agent poisoning in mice.
Topics: Animals; Antidotes; Cholinesterase Inhibitors; Cholinesterase Reactivators; Imidazoles; Lethal Dose 50; Male; Mice; Neuromuscular Blocking Agents; Organophosphate Poisoning; Organophosphates; Oximes; Pyridines; Pyridinium Compounds; Sarin; Soman | 1992 |
Reduction by pyridostigmine pretreatment of the efficacy of atropine and 2-PAM treatment of sarin and VX poisoning in rodents.
Topics: Acetylcholinesterase; Animals; Atropine; Cholinesterase Inhibitors; Cholinesterase Reactivators; Female; Guinea Pigs; Male; Mice; Mice, Inbred ICR; Organophosphate Poisoning; Organophosphates; Organothiophosphorus Compounds; Pralidoxime Compounds; Pyridostigmine Bromide; Sarin | 1992 |
The specificity of carboxylesterase protection against the toxicity of organophosphorus compounds.
Topics: Acetylcholinesterase; Animals; Brain; Carboxylic Ester Hydrolases; In Vitro Techniques; Kinetics; Lethal Dose 50; Male; Organophosphates; Organophosphorus Compounds; Paraoxon; Rats; Rats, Inbred Strains; Sarin; Soman; Substrate Specificity | 1992 |
Effects of some organophosphorus compounds on the binding of a radioligand (8-cyclopentyl 1, 3-[3H]dipropylxanthine) to adenosine receptors in ovine cardiac membranes.
Topics: Animals; Cholinesterase Inhibitors; In Vitro Techniques; Myocardium; Organophosphates; Potassium Channels; Receptors, Purinergic; Sarin; Sheep; Soman; Xanthines | 1991 |
Physostigmine (alone and together with adjunct) pretreatment against soman, sarin, tabun and VX intoxication.
Topics: Animals; Atropine; Benztropine; Cholinesterase Inhibitors; Female; Guinea Pigs; Lethal Dose 50; Male; Organophosphates; Organothiophosphorus Compounds; Physostigmine; Sarin; Soman; Trihexyphenidyl | 1991 |
Efficacy of an oximate-based skin decontaminant against organophosphate nerve agents determined in vivo and in vitro.
Topics: Acetylcholinesterase; Animals; Brain; Chick Embryo; Cholinesterase Inhibitors; Decontamination; Diacetyl; Female; Male; Neurons; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Rats; Rats, Inbred Strains; Sarin; Soman | 1991 |
Putative M2 muscarinic receptors of rat heart have high affinity for organophosphorus anticholinesterases.
Topics: Animals; Cholinesterase Inhibitors; Dioxolanes; Dose-Response Relationship, Drug; Echothiophate Iodide; Insecticides; Male; Myocardium; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Paraoxon; Parasympathomimetics; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Sarin; Soman; Tritium | 1990 |
Comparison of the effects of diisopropylfluorophosphate, sarin, soman, and tabun on toxicity and brain acetylcholinesterase activity in mice.
Topics: Acetylcholinesterase; Animals; Brain; Cholinesterase Inhibitors; Isoflurophate; Lethal Dose 50; Male; Mice; Mice, Inbred ICR; Organophosphates; Organophosphorus Compounds; Sarin; Soman | 1989 |
Role of carboxylesterase in soman, sarin and tabun poisoning in rats.
Topics: Animals; Carboxylic Ester Hydrolases; Cholinesterase Inhibitors; Hydrogen-Ion Concentration; Lethal Dose 50; Male; Organophosphates; Organophosphorus Compounds; Phenobarbital; Rats; Rats, Inbred Strains; Sarin; Soman; Tritolyl Phosphates | 1989 |
Acute effects of soman, sarin, and tabun on microsomal and cytosolic components of the calmodulin system in rat striatum.
Topics: Adenylyl Cyclases; Animals; Ca(2+) Mg(2+)-ATPase; Calcium-Transporting ATPases; Calmodulin; Corpus Striatum; Cytosol; Guanylate Cyclase; Microsomes; Organophosphates; Organophosphorus Compounds; Phosphoric Diester Hydrolases; Protein Kinases; Rats; Rats, Inbred Strains; Sarin; Soman | 1986 |
Acute effects of Soman, Sarin, and Tabun on cyclic nucleotide metabolism in rat striatum.
Topics: Adenylyl Cyclases; Animals; Corpus Striatum; Cyclic AMP; Cyclic GMP; Guanylate Cyclase; Male; Organophosphates; Organophosphorus Compounds; Rats; Rats, Inbred Strains; Sarin; Soman | 1986 |
Partial characterization of an enzyme that hydrolyzes sarin, soman, tabun, and diisopropyl phosphorofluoridate (DFP).
Topics: Animals; Hydrolases; Hydrolysis; Isoflurophate; Kinetics; Liver; Magnesium; Male; Organophosphates; Organophosphorus Compounds; Rats; Rats, Inbred Strains; Sarin; Soman; Stereoisomerism | 1989 |
Binding of some organophosphorus compounds at adenosine receptors in guinea pig brain membranes.
Topics: Animals; Binding, Competitive; Brain; Cell Membrane; Cholinesterase Inhibitors; Guinea Pigs; Kinetics; Organophosphates; Organophosphorus Compounds; Receptors, Purinergic; Sarin; Soman | 1988 |
[Comparative reactivation efficacy of the oximes HI-6 and HGG-12 in the central nervous system and blood of rats poisoned with nerve gases used in warfare].
Topics: Acetylcholinesterase; Animals; Central Nervous System; Chemical Warfare; Cholinesterase Inhibitors; Cholinesterase Reactivators; Gas Poisoning; Organophosphate Poisoning; Organophosphates; Oximes; Pyridinium Compounds; Rats; Sarin; Soman | 1986 |
[The effect of inhibition and activation of ali-esterase on the acute toxicity of organophosphates in rats].
Topics: Acute Disease; Animals; Carboxylesterase; Carboxylic Ester Hydrolases; Enzyme Activation; Organophosphates; Organophosphorus Compounds; Rats; Sarin; Soman; Tritolyl Phosphates | 1986 |
Organophosphorus anticholinesterases do not mediate analgesia through inhibition of enkephalin degradation.
Topics: Acetylcholinesterase; Aminopeptidases; Analgesia; Animals; Brain; Cholinesterase Inhibitors; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Endopeptidases; Enkephalin, Leucine; Enkephalins; Isoflurophate; Male; Neprilysin; Organophosphates; Organophosphorus Compounds; Rats; Rats, Inbred Strains; Sarin; Soman; Synaptosomes | 1986 |
Reactivation of nerve agent inhibited human acetylcholinesterases by HI-6 and obidoxime.
Topics: Acetylcholinesterase; Caudate Nucleus; Cholinesterase Reactivators; Edrophonium; Humans; Muscles; Obidoxime Chloride; Organophosphates; Organothiophosphorus Compounds; Oximes; Pyridinium Compounds; Sarin; Soman; Stereoisomerism | 1986 |
Inactivation of sarin and soman by cyclodextrins in vitro.
Topics: alpha-Cyclodextrins; beta-Cyclodextrins; Cyclodextrins; Dextrins; gamma-Cyclodextrins; Kinetics; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Sarin; Soman; Starch | 1987 |
Detector for organophosphorus compounds in liquid chromatography based on the cholinesterase inhibition reaction.
Topics: Acetylcholinesterase; Air; Animals; Cholinesterase Inhibitors; Cholinesterases; Chromatography, High Pressure Liquid; Electrophorus; Organophosphates; Organophosphorus Compounds; Sarin; Soman; Spectrophotometry, Ultraviolet | 1987 |
Kinetic constants for the inhibition of eel and rabbit brain acetylcholinesterase by some organophosphates and carbamates of military significance.
Topics: Animals; Brain; Carbamates; Chemical Warfare Agents; Cholinesterase Inhibitors; Eels; Kinetics; Neostigmine; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Physostigmine; Rabbits; Sarin; Soman | 1987 |
Relationship between the neurotoxicities of Soman, Sarin and Tabun, and acetylcholinesterase inhibition.
Topics: Animals; Cholinesterase Inhibitors; Corpus Striatum; Injections, Subcutaneous; Male; Mastication; Organophosphates; Organophosphorus Compounds; Rats; Rats, Inbred Strains; Sarin; Seizures; Soman; Tremor | 1986 |
Central respiratory effects versus neuromuscular actions of nerve agents.
Topics: Animals; Cats; Cholinesterase Inhibitors; Diaphragm; Female; Male; Neuromuscular Junction; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Respiratory Center; Respiratory Insufficiency; Sarin; Soman | 1986 |
Interaction of soman with beta-cyclodextrin.
Topics: Acetylcholinesterase; Animals; beta-Cyclodextrins; Binding Sites; Cholinesterase Inhibitors; Cyclodextrins; Dextrins; Drug Interactions; Electrophorus; Humans; Kinetics; Organophosphates; Organophosphorus Compounds; Sarin; Soman; Starch | 1986 |
Studies on low dose sub-acute administration of soman, sarin and tabun in the rat.
Topics: Acetylcholinesterase; Animals; Body Weight; Brain; Cholinesterase Inhibitors; Growth; Insecticides; Male; Organophosphates; Rats; Rats, Inbred Strains; Sarin; Soman; Time Factors | 1985 |
An assessment of comparative acute toxicity of diisopropyl-fluorophosphate, tabun, sarin, and soman in relation to cholinergic and GABAergic enzyme activities in rats.
Topics: 4-Aminobutyrate Transaminase; Animals; Choline O-Acetyltransferase; Cholinesterase Inhibitors; Corpus Striatum; Erythrocytes; gamma-Aminobutyric Acid; In Vitro Techniques; Isoflurophate; Lethal Dose 50; Male; Organophosphates; Organophosphorus Compounds; Parasympathetic Nervous System; Rats; Rats, Inbred Strains; Sarin; Soman | 1984 |
Stereochemical analysis of the nerve agents soman, sarin, tabun, and VX by proton NMR-spectroscopy with optically active shift reagents.
Topics: Cholinesterase Inhibitors; Indicators and Reagents; Magnetic Resonance Spectroscopy; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Sarin; Soman; Stereoisomerism | 1984 |
[Direct reactions of pyridinium oximes with organophosphorus compounds].
Topics: Chemical Phenomena; Chemical Warfare Agents; Chemistry; Drug Interactions; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Sarin; Soman | 1984 |
Antidote effect of sodium fluoride against organophosphate poisoning in mice.
Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Carboxylesterase; Carboxylic Ester Hydrolases; Drug Interactions; Fluorides; Lethal Dose 50; Male; Mice; Organophosphate Poisoning; Organophosphates; Organophosphorus Compounds; Sarin; Sodium Fluoride; Soman | 1983 |
HI-6: reactivation of central and peripheral acetylcholinesterase following inhibition by soman, sarin and tabun in vivo in the rat.
Topics: Acetylcholinesterase; Animals; Brain; Cholinesterase Inhibitors; Cholinesterase Reactivators; Male; Organophosphates; Organophosphorus Compounds; Oximes; Peripheral Nerves; Pyridinium Compounds; Rats; Rats, Inbred Strains; Sarin; Soman | 1982 |
Treatment of nerve gas poisoning.
Topics: Anticonvulsants; Antidotes; Atropine; Chemical Warfare Agents; Cholinesterase Inhibitors; Gases; Humans; Organophosphate Poisoning; Organophosphates; Organothiophosphorus Compounds; Pralidoxime Compounds; Pyridostigmine Bromide; Respiratory Protective Devices; Sarin; Soman | 1995 |
Efficacy of tacrine as a nerve agent pretreatment.
Topics: Acetylcholinesterase; Animals; Behavior, Animal; Chemical Warfare Agents; Dose-Response Relationship, Drug; Female; Guinea Pigs; Male; Mice; Organophosphates; Sarin; Soman; Tacrine | 1994 |
A comparison of the efficacy of HI6 and 2-PAM against soman, tabun, sarin, and VX in the rabbit.
Topics: Animals; Antidotes; Atropine; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Diazepam; Lethal Dose 50; Male; Organophosphate Poisoning; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Poisoning; Pralidoxime Compounds; Pyridinium Compounds; Pyridostigmine Bromide; Rabbits; Sarin; Soman; Specific Pathogen-Free Organisms | 1994 |
Human butyrylcholinesterase as a general prophylactic antidote for nerve agent toxicity. In vitro and in vivo quantitative characterization.
Topics: Animals; Antidotes; Butyrylcholinesterase; Cholinesterase Inhibitors; Half-Life; Humans; Male; Mice; Mice, Inbred ICR; Neutralization Tests; Organophosphates; Organothiophosphorus Compounds; Rats; Rats, Sprague-Dawley; Sarin; Soman | 1993 |
Direct reaction of oximes with sarin, soman, or tabun in vitro.
Topics: Antidotes; Cholinesterase Inhibitors; Half-Life; Organophosphates; Oximes; Sarin; Soman; Spectrophotometry, Ultraviolet | 1997 |
A theoretical model of the competition between hydrolase and carboxylesterase in protection against organophosphorus poisoning.
Topics: Acetylcholinesterase; Animals; Aryldialkylphosphatase; Carboxylic Ester Hydrolases; Cholinesterase Inhibitors; Dichlorvos; Esterases; Isoflurophate; Lethal Dose 50; Models, Biological; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Rats; Sarin; Soman | 1999 |
Expression of biologically active human butyrylcholinesterase in the cabbage looper (Trichoplusia ni).
Topics: Animals; Baculoviridae; Butyrylcholinesterase; Cells, Cultured; Cholinesterase Inhibitors; COS Cells; Glycosylation; Humans; Hydrolysis; Larva; Lepidoptera; Organophosphates; Organophosphorus Compounds; Paraoxon; Protein Engineering; Recombinant Proteins; Sarin; Soman | 2000 |
Efficacy of biperiden and atropine as anticonvulsant treatment for organophosphorus nerve agent intoxication.
Topics: Animals; Anticonvulsants; Atropine; Biperiden; Cholinesterase Inhibitors; Cholinesterase Reactivators; Disease Models, Animal; Drug Therapy, Combination; Electroencephalography; Guinea Pigs; Lethal Dose 50; Male; Organophosphates; Organophosphorus Compounds; Pralidoxime Compounds; Pyridostigmine Bromide; Sarin; Seizures; Soman | 2000 |
Effect of pedological characteristics on aqueous soil extraction recovery and tert-butyldimethylsilylation yield for gas chromatography-mass spectrometry of nerve gas hydrolysis products from soils.
Topics: Chemical Warfare Agents; Gas Chromatography-Mass Spectrometry; Hydrolysis; Organophosphates; Organophosphorus Compounds; Organosilicon Compounds; Sarin; Silanes; Soil Pollutants; Soman; Water | 2001 |
Stand-off tissue-based biosensors for the detection of chemical warfare agents using photosynthetic fluorescence induction.
Topics: Biosensing Techniques; Butylamines; Chemical Warfare Agents; Chlorella; Cyanobacteria; Fluorescence; Mustard Gas; Organophosphates; Photochemistry; Photosynthesis; Sarin; Sulfides | 2001 |
Therapeutic efficacy of the adenosine A1 receptor agonist N6-cyclopentyladenosine (CPA) against organophosphate intoxication.
Topics: Acetylcholine; Adenosine; Animals; Cholinesterase Inhibitors; Cholinesterases; Corpus Striatum; Male; Microdialysis; Organophosphate Poisoning; Organophosphates; Organothiophosphorus Compounds; Parathion; Purinergic P1 Receptor Agonists; Rats; Rats, Wistar; Sarin | 2002 |
Observations on pharmacology of the anticholinesterases sarin and tabun.
Topics: Cholinesterase Inhibitors; Humans; Organophosphates; Phosphates; Sarin | 1954 |
Pyridine-2-aldoxime methiodide in the treatment of sarin and tabun poisoning, with notes on its pharmacology.
Topics: Cholinesterase Inhibitors; Organophosphate Poisoning; Organophosphates; Phosphates; Picolines; Pralidoxime Compounds; Sarin | 1957 |
Studies on the enzymatic hydrolysis of sarin and tabun.
Topics: Humans; Hydrolysis; Organophosphates; Phosphoric Monoester Hydrolases; Sarin | 1958 |
Inhibition of the esteratic activity of thrombin by sarin and tabun.
Topics: Cholinesterase Inhibitors; Esterases; Humans; Organophosphates; Phosphates; Sarin; Thrombin | 1959 |
TOXOGONIN IN SARIN, SOMAN AND TABUN POISONING.
Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Cholinesterase Inhibitors; Cholinesterases; Erythrocytes; Mice; Obidoxime Chloride; Organophosphates; Oximes; Pharmacology; Phosphates; Research; Sarin; Soman; Toxicology | 1965 |
In vitro reactivation of acetylcholinesterase using the oxime K027.
Topics: Acetylcholinesterase; Animals; Cholinesterase Inhibitors; Cholinesterase Reactivators; Dose-Response Relationship, Drug; Obidoxime Chloride; Organophosphates; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Sarin; Structure-Activity Relationship | 2004 |
The birth of nerve agent warfare: lessons from Syed Abbas Foroutan.
Topics: Antidotes; Chemical Warfare; Chemical Warfare Agents; Clinical Protocols; Diagnosis, Differential; Emergency Medical Services; History, 20th Century; Humans; Iran; Iraq; Male; Military Medicine; Military Personnel; Organophosphate Poisoning; Organophosphates; Poisoning; Sarin; Triage; United Nations; Warfare | 2004 |
A comparison of the efficacy of a bispyridinium oxime--1,4-bis-(2-hydroxyiminomethylpyridinium) butane dibromide and currently used oximes to reactivate sarin, tabun or cyclosarin-inhibited acetylcholinesterase by in vitro methods.
Topics: Acetylcholinesterase; Animals; Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Male; Obidoxime Chloride; Organophosphates; Organophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Rats, Wistar; Sarin | 2004 |
Overcoming inhibitions.
Topics: Acetylcholine; Acetylcholinesterase; Animals; Atropine; Benzodiazepines; Blood-Brain Barrier; Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Drug Therapy, Combination; Galantamine; Guinea Pigs; Insecticides; Neurons; Neurotransmitter Agents; Organophosphate Poisoning; Organophosphates; Organophosphorus Compounds; Paraoxon; Pralidoxime Compounds; Pyridostigmine Bromide; Receptors, Cholinergic; Receptors, Muscarinic; Sarin; Seizures; Soman; Time Factors | 2006 |
Currently used cholinesterase reactivators against nerve agent intoxication: comparison of their effectivity in vitro.
Topics: Animals; Brain; Chemical Warfare Agents; Chlorpyrifos; Cholinesterase Inhibitors; Cholinesterase Reactivators; Dose-Response Relationship, Drug; Obidoxime Chloride; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Rats, Wistar; Sarin; Soman; Tissue Extracts; Trimedoxime | 2007 |
Degradation of nerve agents by an organophosphate-degrading agent (OpdA).
Topics: Acetylcholinesterase; Chemical Warfare Agents; Cholinesterase Inhibitors; Hydrolysis; Kinetics; Organophosphates; Organophosphorus Compounds; Phosphoric Triester Hydrolases; Sarin; Soman | 2008 |
Nerve agents: implications for anesthesia providers.
Topics: Antidotes; Atropine; Chemical Terrorism; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Decontamination; Humans; Muscarinic Antagonists; Nurse Anesthetists; Nurse's Role; Organophosphate Poisoning; Organophosphates; Organothiophosphorus Compounds; Pralidoxime Compounds; Sarin; Soman; Time Factors | 2008 |
Crystal structures of human group-VIIA phospholipase A2 inhibited by organophosphorus nerve agents exhibit non-aged complexes.
Topics: Binding Sites; Chemical Warfare Agents; Cholinesterase Inhibitors; Crystallization; Crystallography, X-Ray; Esters; Humans; Hydrolysis; Models, Molecular; Molecular Structure; Organophosphates; Organophosphorus Compounds; Phospholipase A2 Inhibitors; Phospholipases A2; Sarin; Synapses | 2009 |
Chemical synthesis of two series of nerve agent model compounds and their stereoselective interaction with human acetylcholinesterase and human butyrylcholinesterase.
Topics: Acetylcholinesterase; Binding Sites; Butyrylcholinesterase; Chemical Warfare Agents; Cholinesterase Inhibitors; Computer Simulation; Humans; Kinetics; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Protein Binding; Sarin; Soman; Stereoisomerism | 2009 |
Nerve agent analogues that produce authentic soman, sarin, tabun, and cyclohexyl methylphosphonate-modified human butyrylcholinesterase.
Topics: Amino Acid Sequence; Butyrylcholinesterase; Catalytic Domain; Chemical Warfare Agents; Chromatography, High Pressure Liquid; Humans; Molecular Sequence Data; Organophosphates; Organophosphorus Compounds; Peptides; Sarin; Soman; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Thiocholine; Trypsin | 2009 |
Hydroxy oximes as organophosphorus nerve agent sensors.
Topics: Chemical Warfare Agents; Cholinesterase Inhibitors; Organophosphates; Organophosphorus Compounds; Oximes; Sarin; Soman | 2009 |
Detoxification of nerve agents by a substituted beta-cyclodextrin: application of a modified biological assay.
Topics: Acetylcholinesterase; beta-Cyclodextrins; Biological Assay; Buffers; Chemical Warfare Agents; Cholinesterase Inhibitors; Erythrocyte Membrane; Humans; Hydrogen-Ion Concentration; Molecular Structure; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Reference Standards; Reproducibility of Results; Sarin; Time Factors | 2009 |
Kinetic analysis of interactions of different sarin and tabun analogues with human acetylcholinesterase and oximes: is there a structure-activity relationship?
Topics: Acetylcholinesterase; Cholinesterase Inhibitors; Cholinesterase Reactivators; Enzyme Activation; Humans; Kinetics; Obidoxime Chloride; Organophosphates; Oximes; Protein Binding; Pyridinium Compounds; Sarin; Structure-Activity Relationship | 2010 |
Comprehensive gas chromatography with Time of Flight MS and large volume introduction for the detection of fluoride-induced regenerated nerve agent in biological samples.
Topics: Chemical Warfare Agents; Cholinesterase Inhibitors; Fluorides; Gas Chromatography-Mass Spectrometry; Humans; Linear Models; Organophosphates; Organophosphorus Compounds; Reproducibility of Results; Sarin; Sensitivity and Specificity | 2010 |
Neurognostics answer.
Topics: Animals; Chemical Industry; Chemical Warfare Agents; Germany; History, 20th Century; Humans; Insecticides; National Socialism; Organophosphates; Sarin | 2010 |
Protection against nerve agent poisoning by a noncompetitive nicotinic antagonist.
Topics: Animals; Cell Line, Tumor; Chemical Warfare Agents; Diaphragm; Dose-Response Relationship, Drug; Guinea Pigs; Humans; Ion Channel Gating; Male; Muscle Contraction; Nicotinic Antagonists; Organophosphate Poisoning; Organophosphates; Poisoning; Pyridinium Compounds; Sarin; Soman | 2011 |
Restoration of nerve agent inhibited muscle force production in human intercostal muscle strips with HI 6.
Topics: Acetylcholinesterase; Aged; Chemical Warfare Agents; Cholinesterase Reactivators; Electric Stimulation; Humans; In Vitro Techniques; Intercostal Muscles; Muscle Strength; Neuromuscular Junction; Organophosphates; Oximes; Pyridinium Compounds; Sarin; Soman | 2011 |
Hydrolysis potential of recombinant human skin and kidney prolidase against diisopropylfluorophosphate and sarin by in vitro analysis.
Topics: Acetylcholinesterase; Chemical Warfare Agents; Cholinesterase Inhibitors; Dipeptidases; Humans; Hydrolysis; Isoflurophate; Kidney; Liver; Organophosphates; Organothiophosphorus Compounds; Recombinant Proteins; Sarin; Skin | 2012 |
Reactivation kinetics of a homologous series of bispyridinium bis-oximes with nerve agent-inhibited human acetylcholinesterase.
Topics: Acetylcholinesterase; Alkenes; Cholinesterase Inhibitors; Cholinesterase Reactivators; Erythrocyte Membrane; GPI-Linked Proteins; Humans; Kinetics; Molecular Structure; Organophosphates; Organophosphorus Compounds; Oximes; Pyridinium Compounds; Sarin; Structure-Activity Relationship | 2012 |
Structural requirements for effective oximes--evaluation of kinetic in vitro data with phosphylated human AChE and structurally different oximes.
Topics: Acetylcholinesterase; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Drug Evaluation, Preclinical; GPI-Linked Proteins; Humans; Kinetics; Organophosphates; Organophosphorus Compounds; Oximes; Phosphorylation; Sarin; Structure-Activity Relationship | 2013 |
Mechanism of interaction of novel uncharged, centrally active reactivators with OP-hAChE conjugates.
Topics: Acetamides; Acetylcholinesterase; Cholinesterase Inhibitors; Cholinesterase Reactivators; Drug Evaluation, Preclinical; GPI-Linked Proteins; Humans; Kinetics; Models, Molecular; Organophosphates; Organophosphorus Compounds; Oximes; Paraoxon; Sarin | 2013 |
Assessing protection against OP pesticides and nerve agents provided by wild-type HuPON1 purified from Trichoplusia ni larvae or induced via adenoviral infection.
Topics: Animals; Antidotes; Aryldialkylphosphatase; Chemical Warfare Agents; Chlorpyrifos; Guinea Pigs; Humans; Male; Mice; Moths; Organophosphates; Organophosphorus Compounds; Pesticides; Recombinant Proteins; Sarin; Soman | 2013 |
Human paraoxonase double mutants hydrolyze V and G class organophosphorus nerve agents.
Topics: Amino Acid Substitution; Antidotes; Aryldialkylphosphatase; Catalytic Domain; Chemical Warfare Agents; Humans; Hydrolysis; Kinetics; Models, Molecular; Mutagenesis, Site-Directed; Mutant Proteins; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Paraoxon; Protein Engineering; Recombinant Proteins; Sarin; Soman; Substrate Specificity | 2013 |
A 10-minute point-of-care assay for detection of blood protein adducts resulting from low level exposure to organophosphate nerve agents.
Topics: Adult; Blood Chemical Analysis; Blood Proteins; Chemical Warfare Agents; Cholinesterase Inhibitors; Cross Reactions; Humans; Organophosphate Poisoning; Organophosphates; Organothiophosphorus Compounds; Point-of-Care Systems; Sarin; Soman | 2013 |
Using metal complex ion-molecule reactions in a miniature rectilinear ion trap mass spectrometer to detect chemical warfare agents.
Topics: Chemical Warfare Agents; Coordination Complexes; Limit of Detection; Mass Spectrometry; Membranes, Artificial; Mustard Gas; Nickel; Organophosphates; Sarin | 2013 |
In vitro kinetics of nerve agent degradation by fresh frozen plasma (FFP).
Topics: Aryldialkylphosphatase; Aurintricarboxylic Acid; Butyrylcholinesterase; Calcium; Chemical Warfare Agents; Cholinesterase Inhibitors; Edetic Acid; Freezing; Half-Life; Humans; Inactivation, Metabolic; Organophosphates; Organophosphorus Compounds; Plasma; Sarin; Soman | 2014 |
Organophosphorus pesticide and ester analysis by using comprehensive two-dimensional gas chromatography with flame photometric detection.
Topics: Calibration; Chemical Warfare; Chromatography, Gas; Gasoline; Hydrocarbons; Kerosene; Limit of Detection; Organophosphates; Organophosphorus Compounds; Pesticides; Phosphorus; Photometry; Sarin; Soil; Soil Pollutants; Soman; Temperature | 2013 |
Detection of nerve agents using proton transfer reaction mass spectrometry with ammonia as reagent gas.
Topics: Ammonia; Chemical Warfare Agents; Mass Spectrometry; Models, Chemical; Organophosphates; Organophosphonates; Organophosphorus Compounds; Protons; Sarin; Soman; Water | 2013 |
Exploring the physicochemical properties of oxime-reactivation therapeutics for cyclosarin, sarin, tabun, and VX inactivated acetylcholinesterase.
Topics: Acetylcholinesterase; Animals; Chemistry, Physical; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Humans; Mice; Models, Molecular; Molecular Structure; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Rats; Reproducibility of Results; Sarin; Structure-Activity Relationship | 2014 |
Selective chromo-fluorogenic detection of DFP (a Sarin and Soman mimic) and DCNP (a Tabun mimic) with a unique probe based on a boron dipyrromethene (BODIPY) dye.
Topics: Acetonitriles; Boron Compounds; Chemical Warfare Agents; Color; Colorimetry; Humans; Limit of Detection; Membranes, Artificial; Molecular Mimicry; Molecular Probes; Organophosphates; Phosphorylation; Reagent Strips; Sarin; Silica Gel; Solvents; Soman; Substrate Specificity | 2014 |
Chiral separation of G-type chemical warfare nerve agents via analytical supercritical fluid chromatography.
Topics: Chemical Warfare Agents; Chromatography, Supercritical Fluid; Mass Spectrometry; Organophosphates; Organophosphorus Compounds; Sarin; Soman; Spectrometry, Mass, Electrospray Ionization; Stereoisomerism | 2014 |
Identification of chemical warfare agents from vapor samples using a field-portable capillary gas chromatography/membrane-interfaced electron ionization quadrupole mass spectrometry instrument with Tri-Bed concentrator.
Topics: Chemical Warfare Agents; Chemistry Techniques, Analytical; Gas Chromatography-Mass Spectrometry; Gases; Mechlorethamine; Mustard Gas; Organophosphates; Sarin; Soman | 2015 |
Measurement of breakthrough volumes of volatile chemical warfare agents on a poly(2,6-diphenylphenylene oxide)-based adsorbent and application to thermal desorption-gas chromatography/mass spectrometric analysis.
Topics: Adsorption; Chemical Warfare Agents; Gas Chromatography-Mass Spectrometry; Mustard Gas; Organophosphates; Organothiophosphorus Compounds; Phenols; Polymers; Sarin; Soman; Volatilization | 2015 |
Molecular Docking, Metal Substitution and Hydrolysis Reaction of Chiral Substrates of Phosphotriesterase.
Topics: Aluminum; Catalytic Domain; Cholinesterase Inhibitors; Hydrolysis; Kinetics; Metals; Molecular Docking Simulation; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Phosphoric Triester Hydrolases; Sarin; Soman; Stereoisomerism | 2016 |
Probing the activity of a non-oxime reactivator for acetylcholinesterase inhibited by organophosphorus nerve agents.
Topics: Acetylcholinesterase; Animals; Cholinesterase Reactivators; Erythrocytes; Guinea Pigs; Half-Life; Humans; Kinetics; Male; Nerve Agents; Organophosphate Poisoning; Organophosphates; Oximes; Phenols; Pralidoxime Compounds; Recombinant Proteins; Sarin; Soman; Structure-Activity Relationship | 2016 |
A Rapid and Sensitive Strip-Based Quick Test for Nerve Agents Tabun, Sarin, and Soman Using BODIPY-Modified Silica Materials.
Topics: Boron Compounds; Chemical Warfare Agents; Nerve Agents; Organophosphates; Prothrombin Time; Sarin; Silicon Dioxide; Soman | 2016 |
Reactivation of nerve agent-inhibited human acetylcholinesterase by obidoxime, HI-6 and obidoxime+HI-6: Kinetic in vitro study with simulated nerve agent toxicokinetics and oxime pharmacokinetics.
Topics: Acetylcholinesterase; Cholinesterase Reactivators; Drug Therapy, Combination; Humans; Inhalation Exposure; Injections, Intramuscular; Models, Biological; Nerve Agents; Obidoxime Chloride; Organophosphates; Organophosphorus Compounds; Oximes; Pyridinium Compounds; Sarin; Toxicokinetics | 2016 |
The role of the oximes HI-6 and HS-6 inside human acetylcholinesterase inhibited with nerve agents: a computational study.
Topics: Acetylcholinesterase; Chemical Warfare Agents; Cholinesterase Inhibitors; Humans; Molecular Docking Simulation; Molecular Dynamics Simulation; Nerve Agents; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Sarin | 2018 |
Highly selective and sensitive chromogenic detection of nerve agents (sarin, tabun and VX): a multianalyte detection approach.
Topics: Ferrous Compounds; Fluorescent Dyes; Molecular Structure; Nerve Agents; Organophosphates; Organothiophosphorus Compounds; Sarin | 2017 |
In vitro and in silico Evaluation of Non-Quaternary Reactivators of AChE as Antidotes of Organophosphorus Poisoning - a New Hope or a Blind Alley?
Topics: Animals; Antidotes; Blood-Brain Barrier; Butyrylcholinesterase; Cholinesterase Inhibitors; Cholinesterase Reactivators; Computer Simulation; Mice; Organophosphate Poisoning; Organophosphates; Oximes; Paraoxon; Rats; Sarin | 2018 |
"Covalent-Assembly"-Based Fluorescent Probe for Detection of a Nerve-Agent Mimic (DCP) via Lossen Rearrangement.
Topics: Aniline Compounds; Biphenyl Compounds; Chemical Warfare Agents; Fluorescent Dyes; Humans; Isocyanates; Kinetics; Limit of Detection; Molecular Mimicry; Organophosphates; Organophosphorus Compounds; Phenanthridines; Sarin; Soman; Spectrometry, Fluorescence | 2019 |
Evaluation of high-affinity phenyltetrahydroisoquinoline aldoximes, linked through anti-triazoles, as reactivators of phosphylated cholinesterases.
Topics: Acetylcholinesterase; Butyrylcholinesterase; Cholinesterase Inhibitors; Cholinesterase Reactivators; Enzyme Activation; GPI-Linked Proteins; Humans; Kinetics; Nerve Agents; Organophosphate Poisoning; Organophosphates; Organophosphorus Compounds; Organothiophosphorus Compounds; Oximes; Protein Conformation; Sarin; Structure-Activity Relationship | 2020 |
Enantioseparation, in vitro testing, and structural characterization of triple-binding reactivators of organophosphate-inhibited cholinesterases.
Topics: Acetylcholinesterase; Butyrylcholinesterase; Catalytic Domain; Cholinesterase Inhibitors; Crystallography, X-Ray; Enzyme Activation; Humans; In Vitro Techniques; Kinetics; Organophosphates; Organophosphorus Compounds; Oximes; Sarin; Stereoisomerism | 2020 |
Influence of experimental end point on the therapeutic efficacy of the antinicotinic compounds MB408, MB442 and MB444 in treating nerve agent poisoned mice - a comparison with oxime-based treatment.
Topics: Animals; Antidotes; Chemical Warfare Agents; Cholinesterase Reactivators; Lethal Dose 50; Male; Mice; Nicotinic Antagonists; Organophosphate Poisoning; Organophosphates; Organophosphorus Compounds; Oximes; Pyridinium Compounds; Sarin; Soman; Time Factors | 2020 |
Improving Quantification of tabun, sarin, soman, cyclosarin, and sulfur mustard by focusing agents: A field portable gas chromatography-mass spectrometry study.
Topics: Chemical Warfare Agents; Gas Chromatography-Mass Spectrometry; Mustard Gas; Organophosphates; Organophosphorus Compounds; Reference Standards; Sarin; Soman | 2021 |
A Thermophilic Bacterial Esterase for Scavenging Nerve Agents: A Kinetic, Biophysical and Structural Study.
Topics: Amino Acids; Crystallography, X-Ray; Esterases; Kinetics; Nerve Agents; Organophosphates; Organophosphorus Compounds; Paraoxon; Planctomycetales; Planctomycetes; Sarin | 2021 |
Molecular Modeling Studies on the Multistep Reactivation Process of Organophosphate-Inhibited Acetylcholinesterase and Butyrylcholinesterase.
Topics: Acetylcholinesterase; Animals; Butyrylcholinesterase; Catalytic Domain; Cholinesterase Inhibitors; Cholinesterase Reactivators; Cluster Analysis; Enzyme Activation; Humans; Ligands; Mice; Models, Molecular; Molecular Docking Simulation; Organophosphates; Oximes; Phosphorus; Protein Binding; Protein Biosynthesis; Protein Conformation; Quantum Theory; Sarin | 2021 |