t 588 has been researched along with thiophenes in 30 studies
| Studies (t 588) | Trials (t 588) | Recent Studies (post-2010) (t 588) | Studies (thiophenes) | Trials (thiophenes) | Recent Studies (post-2010) (thiophenes) |
|---|---|---|---|---|---|
| 32 | 0 | 1 | 17,012 | 1,961 | 8,038 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (23.33) | 18.2507 |
| 2000's | 22 (73.33) | 29.6817 |
| 2010's | 1 (3.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ano, M; Hirata, K; Kitamura, K; Maekawa, M; Narita, H; Ono, S; Ukai, W; Yamafuji, T | 1 |
| Chaki, H; Kimura, T; Kitamura, K; Maekawa, M; Mozumi, K; Nakada, Y; Narita, H; Ono, S; Todo, Y; Yamafuji, T | 1 |
| Miyazaki, H; Murayama, T; Narita, H; Nomura, Y; Ono, S | 1 |
| Maekawa, M; Murayama, T; Narita, H; Nomura, Y; Ono, S | 2 |
| Maekawa, M; Miyazaki, H; Murayama, T; Narita, H; Nomura, Y; Ono, S | 1 |
| Kimura, T; Kurimoto, H; Ono, T; Tamura, R | 1 |
| Hirata, K; Llinás, R; Moreira, JE; Nakagawa, M; Rosato-Siri, MD; Sugimori, M; Uchitel, OD; Urbano, FJ | 1 |
| Ikeda, K; Iwasaki, Y; Kinoshita, M; Marubuchi, S; Ono, S | 1 |
| Maekawa, M; Murayama, T; Nomura, Y; Satoh, S | 1 |
| Baba, A; Fujita, T; Kimura, Y; Koyama, Y; Lee, E; Matsuda, T; Mori, K; Takuma, K; Tanabe, M; Yamamuro, A | 1 |
| Maekawa, M; Murayama, T; Nomura, Y | 1 |
| Eifuku, S; Kuriwaki, JI; Ono, T; Tamura, R; Yamaguchi, H | 1 |
| Takuma, K | 1 |
| Ichikawa, Y; Igarashi, O; Ikeda, K; Iwasaki, Y; Kinoshita, M; Marubuchi, S; Ono, S | 1 |
| Ago, Y; Baba, A; Maeda, S; Matsuda, T; Sakai, Y; Yamamuro, A | 1 |
| Baba, A; Hatayama, Y; Koyama, Y; Matsuda, T; Sakai, Y; Tsuji, S; Yokoyama, I | 1 |
| Ikeda, K; Iwasaki, Y; Kawazoe, Y; Kinoshita, M; Marubuchi, S; Nakagawa, M; Ono, S; Sakamoto, T; Terashima, N; Watabe, K | 1 |
| Ago, Y; Baba, A; Maeda, S; Matsuda, T; Sakai, Y; Takuma, K; Yamamuro, A | 1 |
| Aoyagi, J; Ichikawa, Y; Igarasi, O; Iguchi, H; Ikeda, K; Iwasaki, Y; Kawabe, S; Konno, S; Marubuchi, S; Ono, S | 1 |
| Hara, A; Maeda, K; Matsubara, M; Nakai, Y; Sawada, A; Yamamoto, T | 1 |
| Aoyagi, J; Fujioka, T; Ichikawa, Y; Igarashi, O; Iguchi, H; Ikeda, K; Iwasaki, Y; Kawabe, K; Konno, S; Marabuchi, S; Ono, S | 1 |
| Baba, A; Fukushima, T; Hatanaka, R; Matsuda, T; Phuagphong, P; Tanaka, K | 1 |
| Hirouchi, M | 1 |
| Kojo, M; Llinás, RR; Nakada, Y; Sugimori, M; Takagi, A; Welsh, JP; Yamaguchi, H; Zeng, XH | 1 |
| Kimura, T; Llinás, RR; Sugimori, M | 1 |
| Hayashi, Y; Kawazoe, Y; Watabe, K | 1 |
| Araki, K; Ikeda, K; Mori, Y; Nakagawa, M; Ogawa, K; Saito, K; Shiotani, A; Watabe, K | 1 |
| Delgado-García, JM; Eleore, L; López-Ramos, JC; Yi, PJ | 1 |
| Anzai, M; Nagao, S | 1 |
2 review(s) available for t 588 and thiophenes
| Article | Year |
|---|---|
[Delayed apoptosis and its regulation in astrocytes].
Topics: Animals; Apoptosis; Astrocytes; Benzoquinones; Calcium; Cells, Cultured; Diethylamines; Humans; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Reperfusion Injury; Sodium-Calcium Exchanger; Thiophenes; Ubiquinone | 2001 |
[Current status and perspectives on the development of therapeutic agents for Alzheimer's disease].
Topics: Alzheimer Disease; Amyloid beta-Peptides; Cholinesterase Inhibitors; Diethylamines; Humans; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Thiophenes | 2004 |
28 other study(ies) available for t 588 and thiophenes
| Article | Year |
|---|---|
Protective effect of R(-)-1-(benzo[b]thiophen-5-yl)- 2-[2-(N,N-diethylamino)ethoxy]ethanol hydrochloride (T-588), a novel cerebral activator, against experimental cerebral anoxia.
Topics: Animals; Benzhydryl Compounds; Central Nervous System Stimulants; Diethylamines; Energy Metabolism; Glycolysis; Hypoxia, Brain; Imipramine; Male; Mice; Mice, Inbred Strains; Pentobarbital; Potassium Cyanide; Scopolamine; Sleep; Tacrine; Thiophenes | 1993 |
A new cognition-enhancing agent, (R)-(-)-1-(benzo[b]thiophen-5-yl)- 2-[2-(N,N-diethylamino)ethoxy]ethanol hydrochloride. Effects on memory impairment in rats generated by cerebral embolization and basal forebrain lesions.
Topics: Animals; Avoidance Learning; Diethylamines; Hypoxia; Intracranial Embolism and Thrombosis; Lethal Dose 50; Male; Mice; Neurotransmitter Agents; Nootropic Agents; Prosencephalon; Rats; Rats, Wistar; Stereoisomerism; Thiophenes | 1995 |
Effects of R(-)-1-(benzo[b]thiophen-5-yl)-2-[2-N,N-diethylamino)ethoxy]ethan ol hydrochloride (T-588), a novel cognitive enhancer, on noradrenaline release in rat cerebral cortical slices.
Topics: Animals; Calcium Chloride; Central Nervous System Stimulants; Cerebral Cortex; Diethylamines; Dose-Response Relationship, Drug; Ethylmaleimide; In Vitro Techniques; Male; Norepinephrine; Rats; Rats, Wistar; Thiophenes | 1997 |
The effects of T-588, a novel cognitive enhancer, on noradrenaline uptake and release in rat cerebral cortical slices.
Topics: Adrenergic Uptake Inhibitors; Animals; Calcium Chloride; Central Nervous System Stimulants; Cerebral Cortex; Desipramine; Diethylamines; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Norepinephrine; Potassium Chloride; Rats; Rats, Wistar; Reserpine; Thiophenes; Tyramine | 1998 |
Effects of T-588, a novel cognitive enhancer, on ADP-ribosylation of G(s alpha) by cholera toxin and cyclic AMP accumulation in rat cerebral cortex.
Topics: Adenosine Diphosphate Ribose; Adenylyl Cyclases; Animals; Binding Sites; Catalysis; Cerebral Cortex; Cholera Toxin; Cyclic AMP; Diethylamines; Guanosine 5'-O-(3-Thiotriphosphate); Isoproterenol; Nootropic Agents; Pertussis Toxin; Phosphorus Radioisotopes; Rats; Thiophenes; Virulence Factors, Bordetella | 1999 |
Effects of T-588, a newly synthesized cognitive enhancer, on hippocampal CA1 neurons in rat brain tissue slices.
Topics: 2-Amino-5-phosphonovalerate; Acetylcholine; Animals; Atropine; Diethylamines; Hippocampus; In Vitro Techniques; Linear Models; Male; Membrane Potentials; Muscarinic Antagonists; Neurons; Nootropic Agents; Patch-Clamp Techniques; Rats; Rats, Wistar; Tetrodotoxin; Thiophenes | 1999 |
Reduced facilitation and vesicular uptake in crustacean and mammalian neuromuscular junction by T-588, a neuroprotective compound.
Topics: Action Potentials; Animals; Astacoidea; Calcium; Diethylamines; Endocytosis; Glutamic Acid; Male; Mice; Neuromuscular Junction; Neuroprotective Agents; Potassium Channels; Sodium Channels; Synaptic Transmission; Synaptic Vesicles; Thiophenes | 1999 |
T-588, a novel neuroprotective agent, delays progression of neuromuscular dysfunction in wobbler mouse motoneuron disease.
Topics: Administration, Oral; Animals; Cell Count; Cells, Cultured; Central Nervous System Stimulants; Choline O-Acetyltransferase; Cyclic AMP; Diethylamines; Disease Models, Animal; Disease Progression; Drug Evaluation, Preclinical; Forelimb; Hand Strength; L-Lactate Dehydrogenase; Mice; Mice, Inbred C57BL; Mice, Neurologic Mutants; Motor Neuron Disease; Muscle, Skeletal; Organ Size; Spinal Cord; Thiophenes | 2000 |
Involvement of Hg2+-sensitive sulfhydryl groups in regulating noradrenaline release induced by S-nitrosocysteine in rat brain slices.
Topics: Animals; Brain; Calcium Chloride; Central Nervous System Stimulants; Cerebral Cortex; Cysteine; Diethylamines; Ethylmaleimide; In Vitro Techniques; Male; Mercuric Chloride; Mercury; Nitroso Compounds; Norepinephrine; p-Chloromercuribenzoic Acid; Rats; Rats, Wistar; S-Nitrosothiols; Sulfhydryl Compounds; Thiophenes | 2000 |
Stimulation of noradrenaline release by T-588, a cognitive enhancer, in PC12 cells.
Topics: Animals; Biological Transport; Calcium; Central Nervous System Stimulants; Cognition; Diethylamines; Dose-Response Relationship, Drug; Membrane Proteins; Nerve Tissue Proteins; Norepinephrine; PC12 Cells; Rats; Synaptic Vesicles; Synaptophysin; Synaptosomal-Associated Protein 25; Thiophenes | 2000 |
T-588 inhibits astrocyte apoptosis via mitogen-activated protein kinase signal pathway.
Topics: Androstadienes; Animals; Apoptosis; Astrocytes; Central Nervous System Stimulants; Diethylamines; Hydrogen Peroxide; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Nerve Growth Factor; Phosphorylation; Rats; Rats, Sprague-Dawley; Rats, Wistar; Reperfusion Injury; Thiophenes; Wortmannin | 2000 |
Involvement of noradrenaline transporters in S-nitrosocysteine-stimulated noradrenaline release from rat brain slices: existence of functional Na(+)-independent transporter activity.
Topics: Adrenergic Uptake Inhibitors; Amiloride; Animals; Biological Transport; Brain; Carrier Proteins; Central Nervous System Stimulants; Cerebral Cortex; Cysteine; Desipramine; Diethylamines; Hippocampus; In Vitro Techniques; Male; Nitroso Compounds; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Ouabain; Potassium Chloride; Rats; Rats, Wistar; Reserpine; S-Nitrosothiols; Sodium; Symporters; Thiophenes; Tritium | 2001 |
Effects of T-588, a cognitive enhancer compound, on synaptic plasticity in the dentate gyrus of freely moving rats.
Topics: Animals; Central Nervous System Stimulants; Dentate Gyrus; Diethylamines; Long-Term Potentiation; Male; Neuronal Plasticity; Nootropic Agents; Rats; Rats, Inbred F344; Thiophenes | 2001 |
T-588 enhances neurite outgrowth and choline acetyltransferase in cultured rat spinal ventral horn neurons.
Topics: Animals; Anterior Horn Cells; Cells, Cultured; Choline O-Acetyltransferase; Diethylamines; Embryo, Mammalian; Neurites; Organ Culture Techniques; Rats; Rats, Sprague-Dawley; Spinal Cord; Thiophenes; Time Factors | 2002 |
Protective effect of T-588 on toxic damage by serum deprivation and amyloid-beta protein in cultured neurons.
Topics: Amyloid beta-Peptides; Animals; Cell Line, Tumor; Cells, Cultured; Cerebral Cortex; Culture Media, Serum-Free; Diethylamines; Humans; Mitogen-Activated Protein Kinases; Neurons; Neuroprotective Agents; Peptide Fragments; Rats; Thiophenes | 2003 |
T-588, a cognitive enhancer, stimulates in vivo phosphorylation of extracellular signal-regulated kinases in the hippocampus.
Topics: Animals; Diethylamines; Dose-Response Relationship, Drug; Hippocampus; Male; Mice; Mitogen-Activated Protein Kinases; Nootropic Agents; Phosphorylation; Rats; Rats, Wistar; Thiophenes | 2003 |
Oral administration of a neuroprotective compound T-588 prevents motoneuron degeneration after facial nerve avulsion in adult rats.
Topics: Administration, Oral; Age Factors; Animals; Body Weight; Cell Survival; Choline O-Acetyltransferase; Diethylamines; Facial Nerve Injuries; Glial Fibrillary Acidic Protein; Immunohistochemistry; Lectins; Male; Motor Neuron Disease; Motor Neurons; Neuroprotective Agents; Rats; Rats, Inbred F344; Thiophenes | 2003 |
Possible involvement of astrocytes in neuroprotection by the cognitive enhancer T-588.
Topics: Animals; Astrocytes; Cells, Cultured; Culture Media, Conditioned; Diethylamines; Phosphorylation; Rats; Thiophenes | 2003 |
T-588 protects motor neuron death against glutamate-induced neurotoxicity.
Topics: Animals; Cell Death; Choline O-Acetyltransferase; Diethylamines; Glutamic Acid; Motor Neurons; Organ Culture Techniques; Rats; Rats, Sprague-Dawley; Thiophenes | 2003 |
A novel neuroprotectant against retinal ganglion cell damage in a glaucoma model and an optic nerve crush model in the rat.
Topics: Animals; Cell Count; Cell Death; Cell Survival; Diethylamines; Disease Models, Animal; Intraocular Pressure; Male; Nerve Crush; Neuroprotective Agents; Ocular Hypertension; Optic Nerve; Optic Nerve Diseases; Rats; Rats, Wistar; Retinal Ganglion Cells; Thiophenes | 2004 |
T-588 protects motor neuron death following axotomy.
Topics: Animals; Animals, Newborn; Axotomy; Cell Survival; Denervation; Diethylamines; In Vitro Techniques; Injections, Intraperitoneal; Lumbar Vertebrae; Motor Neurons; Nerve Growth Factors; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Spinal Cord; Thiophenes | 2004 |
T-588, a cognitive enhancer, protects against sodium nitroprusside-induced toxicity in cultured astrocytes.
Topics: Animals; Astrocytes; Cells, Cultured; Diethylamines; Neuroprotective Agents; Nitroprusside; Nootropic Agents; Rats; Rats, Wistar; Thiophenes | 2004 |
Normal motor learning during pharmacological prevention of Purkinje cell long-term depression.
Topics: Animals; Blinking; Diethylamines; Learning; Motor Activity; Neural Inhibition; Purkinje Cells; Rats; Rats, Sprague-Dawley; Thiophenes | 2005 |
Purkinje cell long-term depression is prevented by T-588, a neuroprotective compound that reduces cytosolic calcium release from intracellular stores.
Topics: Animals; Caffeine; Calcium; Central Nervous System Stimulants; Cytosol; Diethylamines; Male; Mice; Mice, Inbred ICR; Neural Inhibition; Neuroprotective Agents; Purkinje Cells; Thiophenes | 2005 |
Peripheral nerve avulsion injuries as experimental models for adult motoneuron degeneration.
Topics: Adenoviridae; Animals; Brain-Derived Neurotrophic Factor; Diethylamines; Disease Models, Animal; Facial Nerve Injuries; Gene Transfer Techniques; Genetic Vectors; Glial Cell Line-Derived Neurotrophic Factor; Male; Metallothionein 3; Motor Neuron Disease; Motor Neurons; Nerve Degeneration; Nerve Tissue Proteins; Neuroprotective Agents; Peripheral Nerve Injuries; Peripheral Nerves; Rats; Thiophenes; Transforming Growth Factor beta | 2005 |
A novel drug therapy for recurrent laryngeal nerve injury using T-588.
Topics: Animals; Diethylamines; Electromyography; Laryngeal Muscles; Male; Motor Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Thiophenes; Treatment Outcome; Vocal Cord Paralysis | 2007 |
The cognitive enhancer T-588 partially compensates the motor associative learning impairments induced by scopolamine injection in mice.
Topics: Acoustic Stimulation; Analysis of Variance; Animals; Association Learning; Avoidance Learning; Behavior, Animal; Conditioning, Eyelid; Diethylamines; Drug Interactions; Electromyography; Inhibition, Psychological; Learning Disabilities; Male; Mice; Motor Activity; Psychomotor Performance; Reaction Time; Recognition, Psychology; Scopolamine; Thiophenes; Time Factors | 2007 |
Motor learning in common marmosets: vestibulo-ocular reflex adaptation and its sensitivity to inhibitors of Purkinje cell long-term depression.
Topics: Adaptation, Physiological; Animals; Callithrix; Diethylamines; Eye Movement Measurements; Eye Movements; Female; Learning; Long-Term Synaptic Depression; Male; Purkinje Cells; Reflex, Vestibulo-Ocular; Sulfonamides; Thiophenes | 2014 |