Page last updated: 2024-08-23

stepronin and glycine

stepronin has been researched along with glycine in 24 studies

*Glycine: A non-essential amino acid. It is found primarily in gelatin and silk fibroin and used therapeutically as a nutrient. It is also a fast inhibitory neurotransmitter. [MeSH]

*Glycine: A non-essential amino acid. It is found primarily in gelatin and silk fibroin and used therapeutically as a nutrient. It is also a fast inhibitory neurotransmitter. [MeSH]

Research

Studies (24)

TimeframeStudies, this research(%)All Research%
pre-199014 (58.33)18.7374
1990's9 (37.50)18.2507
2000's0 (0.00)29.6817
2010's1 (4.17)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Brimacombe, KR; Dulcey, AE; Goldsborough, AS; Gottesman, MM; Griffiths, G; Hall, MD; Handley, MD; Kannan, P; Pluchino, KM1
Arrigoni Martelli, E; Bruno, G; Chassard, D; Douin, MJ; Giubilei, C; Marzo, A; Mignot, A; Nava, D; Thebault, JJ1
Arrigoni Martelli, E; Bruno, G; Lefebvre, MA; Marzo, A; Mignot, A; Nava, D; Vidal, R1
Allocca, F; Antenora, G; Assunto, A; Bossone, V; De Rensis, L; Schianchi, L1
Barbieri, P; Gaiani, P; Guslandi, M; Nannini, D1
Allegra, L; Bossi, R; Braga, PC1
Ardizzi, A; Della Toffola, A; Galietti, F; Giorgis, GE; Miravalle, C; Oliaro, A; Scappaticci, E1
Barrett-Bee, K; Cox, A; Davis, SS; Marriott, C; Readman, AS1
Duranti, L; Galmuzzi, G; Lisciani, R; Oriani, G; Zeuli, L1
Bousquet, E; Fiumara, A; Guarcello, V; Matera, M; Morale, MC; Rizza, V1
Radice, G; Rugarli, G1
Andreoni, G; Bosio, G; Bramato, C; Magliocca, R; Salassa, B1
Acone, A; Ciani, A; Dotta, F; Nava, D1
Bruno, M; Fruttero, B; Linari, F; Marangella, M1
Gnemi, P; Mondino, A; Segre, G; Silvestri, S; Zanolo, G1
Di Blasio, P; Gasparini Cesari, M; Palmieri, B1
Casaretti, L; Magliocca, R1
Boraldi, F; Palmieri, B1
Arrigoni-Martelli, E; de Giorgi, L; Matossian-Rogers, A1
Sasaki, T; Satoh, M; Shimura, S; Shirato, K; Takishima, T; Yamada, K1
di Fonso, M; Pietrantonio, F; Pocobelli, D; Romano, A; Venuti, A1
Hanley, MR; Kim, HY; Thomas, D1
Di Fonso, M; Giuffreda, F; Mormile, F; Quaratino, D; Romano, A; Venuti, A1
Broadhurst, K; Carminati, P; de Giorgi, L; Habeshaw, JA; Oxford, JS1

Trials

5 trial(s) available for stepronin and glycine

ArticleYear
Pharmacokinetics of 2-(alpha-thenoylthio)-propionylglycine (TTPG) in healthy volunteers--an oral dose-proportionality investigation.
    Journal of pharmaceutical and biomedical analysis, 1992, Volume: 10, Issue:9

    Topics: Adult; Carboxylic Acids; Chromatography, High Pressure Liquid; Expectorants; Female; Glycine; Half-Life; Humans; Male; Spectrophotometry, Ultraviolet; Sulfides; Thiophenes; Tiopronin

1992
[A controlled clinical study on the efficacy and tolerability of stepronin in chronic alcoholic liver diseases].
    La Clinica terapeutica, 1990, Nov-15, Volume: 135, Issue:3

    Topics: Adult; Aged; Drug Tolerance; Female; Glycine; Humans; Liver Diseases, Alcoholic; Male; Middle Aged; Sulfides; Thiophenes; Time Factors

1990
Rheological modifications of mucus in chronic bronchitic patients after treatment with stepronine-lysine salt.
    Drugs under experimental and clinical research, 1987, Volume: 13, Issue:11

    Topics: Adult; Aged; Bronchitis; Chronic Disease; Double-Blind Method; Elasticity; Expectorants; Glycine; Humans; Middle Aged; Random Allocation; Rheology; Sputum; Sulfides; Thiophenes; Viscosity

1987
[Efficacy of the simultaneous aerosol administration of fenoterol and 2(alpha-thenoylthio)propionylglycine].
    Minerva medica, 1986, Oct-13, Volume: 77, Issue:39

    Topics: Aerosols; Aged; Clinical Trials as Topic; Double-Blind Method; Expectorants; Female; Fenoterol; Forced Expiratory Volume; Glycine; Humans; Lung Diseases, Obstructive; Male; Middle Aged; Sputum; Sulfides; Thiophenes; Time Factors; Viscosity

1986
[The therapeutic activity of stepronin in viral hepatitis].
    Minerva medica, 1982, Oct-27, Volume: 73, Issue:41

    Topics: Adolescent; Adult; Aged; Bilirubin; Child; Clinical Trials as Topic; Female; Glucose; Glycine; Hepatitis, Viral, Human; Humans; Male; Middle Aged; Sulfides; Thiophenes; Transaminases

1982

Other Studies

19 other study(ies) available for stepronin and glycine

ArticleYear
Collateral sensitivity of multidrug-resistant cells to the orphan drug tiopronin.
    Journal of medicinal chemistry, 2011, Jul-28, Volume: 54, Issue:14

    Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; HEK293 Cells; Humans; Multidrug Resistance-Associated Proteins; Orphan Drug Production; Paclitaxel; RNA Stability; RNA, Messenger; Structure-Activity Relationship; Tiopronin

2011
High-performance liquid chromatographic evaluation of 2-(alpha-thenoylthio)propionylglycine and its two metabolites in biological fluids.
    Journal of chromatography, 1991, Jan-04, Volume: 536, Issue:1-2

    Topics: Chromatography, High Pressure Liquid; Glycine; Humans; Reference Values; Spectrophotometry, Ultraviolet; Sulfides; Thiophenes

1991
Noninvolvement of gastric mucus in the mucolytic effect of stepronine lysine salt.
    International journal of clinical pharmacology research, 1988, Volume: 8, Issue:3

    Topics: Adolescent; Adult; Expectorants; Female; Gastric Mucosa; Glycine; Humans; Male; Middle Aged; Mucus; Sulfides; Thiophenes

1988
A new mucotropic agent--in vitro and in vivo evaluation of 2-alpha-thenoylthiopropionylglycine (bronchoplus).
    European journal of respiratory diseases, 1985, Volume: 67, Issue:2

    Topics: Acetylcysteine; Animals; Dithiothreitol; Expectorants; Glycine; Humans; Hydrogen-Ion Concentration; Hydrolysis; Models, Biological; Mucus; Rheology; Sulfides; Swine; Swine, Miniature; Thiophenes; Time Factors; Viscosity

1985
Gastrointestinal absorption of 2-(alpha-thenoylthio)propionylglycine (TTPG) in healthy volunteers: a comparative study between two different pharmaceutical forms.
    Il Farmaco; edizione pratica, 1985, Volume: 40, Issue:10

    Topics: Adult; Antiviral Agents; Female; Glycine; Humans; Intestinal Absorption; Male; Middle Aged; Solutions; Sulfides; Tablets; Thiophenes

1985
The effects of 2-(alpha-Tenoyl) thiopropionylglycine (TTPG) on human lung mucus.
    International journal of tissue reactions, 1983, Volume: 5, Issue:2

    Topics: Centrifugation, Density Gradient; Expectorants; Glycine; Humans; Lung; Microsomes; Mucus; Solubility; Sulfides; Thiolester Hydrolases; Thiophenes

1983
[Effect of stepronin on alcohol metabolism. An experimental study in the rabbit].
    Bollettino chimico farmaceutico, 1982, Volume: 121, Issue:2

    Topics: Alcohol Oxidoreductases; Animals; Carbon Tetrachloride Poisoning; Ethanol; Glycine; In Vitro Techniques; Liver; Rabbits; Sulfides; Thiophenes; Time Factors

1982
[Efficacy of mucotropic agents in the treatment of bronchial asthma. Preliminary study of 2-(alpha-thenoylthio)-propionylglycine].
    La Clinica terapeutica, 1983, May-31, Volume: 105, Issue:4

    Topics: Adult; Asthma; Drug Evaluation; Expectorants; Female; Glycine; Humans; Male; Middle Aged; Sulfides; Thiophenes

1983
[Cystinuria: clinical and therapeutic aspects].
    Bollettino chimico farmaceutico, 1982, Volume: 121, Issue:2

    Topics: Adolescent; Adult; Aged; Child; Cystinuria; Drug Evaluation; Glycine; Humans; Kinetics; Middle Aged; Penicillamine; Sulfides; Thiophenes; Tiopronin

1982
[Serum kinetics and biotransformation of prostenoglycine in the rat, dog and monkey].
    Bollettino chimico farmaceutico, 1981, Volume: 120, Issue:1

    Topics: Animals; Biotransformation; Dogs; Glycine; Macaca fascicularis; Rats; Species Specificity; Sulfides; Thiophenes

1981
[Protective action of prostenoglycine in in-vitro experimental erythrocyte poisoning].
    La Clinica terapeutica, 1981, Dec-31, Volume: 99, Issue:6

    Topics: Erythrocytes; Glycine; In Vitro Techniques; Phenylhydrazines; Sulfhydryl Compounds; Sulfides; Thiophenes

1981
[Mechanism of hepatocyte-protective action of prostenoglycine].
    La Clinica terapeutica, 1981, Dec-31, Volume: 99, Issue:6

    Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Glycine; Liver; Rats; Rats, Inbred Strains; Sulfhydryl Compounds; Sulfides; Thiophenes

1981
[Changes in the hepatocyte concentration of glutathione after administration of stepronin. Histochemical study].
    Bollettino chimico farmaceutico, 1981, Volume: 120, Issue:12

    Topics: Adult; Female; Glutathione; Glycine; Histocytochemistry; Humans; Liver; Male; Middle Aged; Sulfides; Thiophenes

1981
Immunosuppressive effect of stepronin (TS-5010680) in mice.
    Transplantation proceedings, 1994, Volume: 26, Issue:6

    Topics: Animals; Cells, Cultured; Concanavalin A; Glycine; Graft vs Host Disease; Immunosuppressive Agents; Lymph Nodes; Lymphocyte Activation; Lymphocyte Culture Test, Mixed; Lymphocyte Transfusion; Lymphocytes; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred CBA; Skin Transplantation; Spleen; Sulfides; Thiophenes; Transplantation, Homologous

1994
An expectorant, stepronin, reduces airway secretion in vitro.
    Respiration; international review of thoracic diseases, 1994, Volume: 61, Issue:1

    Topics: Amiloride; Animals; Cats; Culture Techniques; Dogs; Dose-Response Relationship, Drug; Epithelium; Expectorants; Female; Glycine; Indomethacin; Isoproterenol; Male; Membrane Potentials; Mucus; Structure-Activity Relationship; Sulfides; Thiophenes; Trachea

1994
Delayed hypersensitivity to stepronin: a case report.
    Contact dermatitis, 1993, Volume: 29, Issue:3

    Topics: Aerosols; Aged; Bronchial Provocation Tests; Drug Eruptions; Expectorants; Facial Dermatoses; Female; Glycine; Humans; Hypersensitivity, Delayed; Intradermal Tests; Lung Diseases, Obstructive; Sulfides; Thiophenes

1993
Stimulation of Ca(2+)-dependent membrane currents in Xenopus oocytes by microinjection of pyrimidine nucleotide-glucose conjugates.
    Molecular pharmacology, 1996, Volume: 49, Issue:2

    Topics: Adenosine Diphosphate Glucose; Animals; Calcium; Cell Membrane; Chelating Agents; Egtazic Acid; Female; Glucose; Glycine; Guanosine Diphosphate Sugars; Inositol 1,4,5-Trisphosphate; Kinetics; Membrane Potentials; Microinjections; Nucleoside Diphosphate Sugars; Oocytes; Sulfides; Thiophenes; Uridine Diphosphate Glucose; Xenopus

1996
Accelerated cell-mediated broncho-obstructive reaction to inhaled stepronin: a case report.
    Allergy, 1996, Volume: 51, Issue:4

    Topics: Administration, Inhalation; Adult; Bronchial Spasm; Drug Eruptions; Expectorants; Glycine; Humans; Hypersensitivity, Delayed; Immunity, Cellular; Male; Respiratory Hypersensitivity; Sulfides; Thiophenes

1996
Anti-human immunodeficiency virus activity of a new immunosuppressant drug called stepronin.
    Transplantation proceedings, 1999, Volume: 31, Issue:8

    Topics: Anti-HIV Agents; Cell Survival; Cells, Cultured; Glycine; HIV-1; Humans; Immunosuppressive Agents; Lymphocytes; Sulfides; Thiophenes; U937 Cells; Virus Replication

1999