spermine and msi 1436
spermine has been researched along with msi 1436 in 25 studies
Research
Studies (25)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (20.00) | 29.6817 |
| 2010's | 11 (44.00) | 24.3611 |
| 2020's | 9 (36.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Anderson, M; Chen, Q; Cheshire, K; Holroyd, K; Jones, S; Kinney, W; Maeder, T; McLane, M; Williams, JI; Zasloff, M | 1 |
| Jones, SR; Kinney, WA; Selinsky, BS; Shu, Y | 1 |
| Ahima, RS; Hileman, SM; Patel, HR; Qi, Y; Takahashi, N; Zasloff, MA | 1 |
| Brunel, JM; Letourneux, Y; Loncle, C; Salmi, C; Vidal, N | 1 |
| Brunel, JM; Laget, M; Letourneux, Y; Loncle, C; Salmi, C; Vidal, N | 1 |
| Hart, SG; Lantz, KA; McLane, MP; Planey, SL; Roitman, MF; Ruiz-White, IA; Wolfe, HR | 1 |
| Cone, JJ; McLane, MP; Roitman, MF; Wescott, S; Wolfe, HR | 1 |
| Brunel, JM; Djouhri-Bouktab, L; Rolain, JM; Vidal, N | 1 |
| Fan, G; Lin, G; Lucito, R; Tonks, NK | 1 |
| Anisman, H; Brunel, JM; Chen, HH; Gomez-Smith, M; Keyhanian, K; Pandey, NR; Qin, Z; Stewart, AF; Zaman, T; Zhou, X | 1 |
| Akshinthala, SD; Blackledge, M; Gauss, CM; Jensen, MR; Koveal, D; Kragelj, J; Krishnan, N; Miller, DH; Muthuswamy, SK; Page, R; Peti, W; Tonks, NK; Xue, B | 1 |
| Brunel, JM; Chen, HH; Hari, A; Huang, H; Pandey, NR; Qin, Z; Stewart, AF; Stewart, CA; Zhou, X | 1 |
| Delibegovic, M; Grant, L; Le Sommer, S; Lees, EK; Mody, N; Morrice, N; Thompson, D; Wilson, HM | 1 |
| Brunel, JM; Coquerel, D; Delile, E; Renet, S; Richard, V; Tamion, F; Thiebaut, PA | 1 |
| Aprile, FA; Barbut, D; Cascella, R; Cecchi, C; Challa, PK; Chen, SW; Chiti, F; Cohen, SIA; Cremades, N; Dobson, CM; Flagmeier, P; Galvagnion, C; Heller, GT; Kirkegaard, JB; Knowles, TPJ; Kumita, JR; Limbocker, R; Mannini, B; Meisl, G; Nollen, EAA; Perni, M; Vendruscolo, M; Zasloff, M | 1 |
| Ahn, M; Cascella, R; Casford, ST; Cecchi, C; Challa, PK; Chia, S; Chiti, F; Cohen, SIA; Dobson, CM; Fernando, N; Habchi, J; Heller, GT; Kloss, ND; Knowles, TPJ; Kumita, JR; Limbocker, R; Linse, S; Mannini, B; Meisl, G; Michaels, TCT; Perni, M; Ruggeri, FS; Vendruscolo, M; Xu, CK; Zasloff, M | 1 |
| Chen, HH; Cruz, SA; Farrokhi, K; Qin, Z; Ricke, KM; Sharmin, F; Stewart, AFR; Zasloff, MA; Zhang, L | 1 |
| Albright, JA; Bigi, A; Cascella, R; Cecchi, C; Chen, SW; Chia, S; Chiti, F; Cremades, N; Dobson, CM; Habchi, J; Kartanas, T; Knowles, TPJ; Kreiser, RP; Kumita, JR; Limbocker, R; Mannini, B; Perni, M; Ruggeri, FS; Vendruscolo, M; Wright, AK; Xu, CK; Zasloff, M | 1 |
| Barbut, D; Bugelli, C; Calamai, M; Caminati, G; Canale, C; Capitini, C; Chiti, F; Danani, A; Errico, S; Ferrando, R; Grasso, G; Lucchesi, G; Muscat, S; Odino, D; Relini, A; Vendruscolo, M; Zasloff, M | 1 |
| Chen, HH; Qin, Z; Stewart, AFR; Zasloff, MA; Zhang, L | 1 |
| Chen, HH; Lin, W; Qin, Z; Ricke, KM; Sharmin, F; Stewart, AFR; Zasloff, MA; Zhang, L | 1 |
| Barbut, D; Calamai, M; Canale, C; Capitini, C; Chiti, F; Errico, S; Oropesa-Nuñez, R; Ramshini, H; Spaziano, M; Vendruscolo, M; Zasloff, M | 1 |
| Barbut, D; Chiti, F; Errico, S; Knowles, TPJ; Limbocker, R; Vendruscolo, M; Zasloff, M | 1 |
| Babkov, D; Giniyatullina, G; Kazakova, O; Wimmer, Z | 1 |
| Calamai, M; Capitini, C; Chiti, F; Fani, G; Franceschini, A; Genovese, M; Mazzamuto, G; Paoli, P; Pavone, FS; Pesce, L; Pieraccini, G; Zasloff, M | 1 |
Reviews
2 review(s) available for spermine and msi 1436
| Article | Year |
|---|---|
Squalamine and trodusquemine: two natural products for neurodegenerative diseases, from physical chemistry to the clinic.
Topics: Alzheimer Disease; Animals; Biological Products; Chemistry, Physical; Cholestanes; Cholestanols; Humans; Neurodegenerative Diseases; Spermine | 2022 |
From Marine Metabolites to the Drugs of the Future: Squalamine, Trodusquemine, Their Steroid and Triterpene Analogues.
Topics: Angiogenesis Inhibitors; Anti-Infective Agents; Antineoplastic Agents; Aquatic Organisms; Biological Products; Cholestanes; Cholestanols; Humans; Neuroprotective Agents; Spermine; Steroids; Triterpenes | 2022 |
Other Studies
23 other study(ies) available for spermine and msi 1436
| Article | Year |
|---|---|
A spermine-coupled cholesterol metabolite from the shark with potent appetite suppressant and antidiabetic properties.
Topics: Animals; Appetite Depressants; Cholestanes; Diabetes Mellitus; Disease Models, Animal; Dogfish; Drinking; Eating; Hypoglycemic Agents; Mice; Mice, Obese; Obesity; Rats; Rats, Sprague-Dawley; Spermine; Weight Loss | 2001 |
The synthesis of spermine analogs of the shark aminosterol squalamine.
Topics: Animals; Anti-Bacterial Agents; Anti-Infective Agents; Candida albicans; Cholestanes; Cholestanols; Dogfish; Escherichia coli; Hydroxylation; Magnetic Resonance Spectroscopy; Molecular Structure; Pseudomonas aeruginosa; Spermine; Staphylococcus aureus; Stereoisomerism; Stigmasterol; Structure-Activity Relationship | 2002 |
Appetite suppression and weight reduction by a centrally active aminosterol.
Topics: Animals; Anticarcinogenic Agents; Appetite Depressants; Brain; Cerebral Ventricles; Cholestanes; Cholestanols; Energy Intake; Energy Metabolism; Injections, Intraventricular; Mice; Mice, Inbred C57BL; Paraventricular Hypothalamic Nucleus; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Reference Values; Spermine; Weight Loss | 2002 |
New stereoselective titanium reductive amination synthesis of 3-amino and polyaminosterol derivatives possessing antimicrobial activities.
Topics: Amination; Anti-Infective Agents; Bacteria; Cholestanes; Cholestanols; Drug Design; Microbial Sensitivity Tests; Oxidation-Reduction; Polyamines; Sensitivity and Specificity; Spermine; Stereoisomerism; Sterols; Titanium | 2008 |
Antimicrobial activities of 3-amino- and polyaminosterol analogues of squalamine and trodusquemine.
Topics: Amines; Anti-Bacterial Agents; Cholestanes; Cholestanols; Microbial Viability; Molecular Structure; Spermine; Sterols; Structure-Activity Relationship | 2008 |
Inhibition of PTP1B by trodusquemine (MSI-1436) causes fat-specific weight loss in diet-induced obese mice.
Topics: Animals; Appetite; Body Composition; Cholestanes; Diet; Disease Models, Animal; Hep G2 Cells; Humans; Hypolipidemic Agents; Hypothalamus; Insulin; Leptin; Male; Mice; Mice, Inbred AKR; Mice, Obese; Obesity; Phosphorylation; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Receptor, Insulin; Spermine; STAT3 Transcription Factor; Weight Loss | 2010 |
MSI-1436 reduces acute food intake without affecting dopamine transporter activity.
Topics: Animals; Anti-Obesity Agents; Cholestanes; Dopamine Plasma Membrane Transport Proteins; Eating; Male; Rats; Rats, Sprague-Dawley; Spermine; Time Factors | 2010 |
Synthesis of new 3,20-bispolyaminosteroid squalamine analogues and evaluation of their antimicrobial activities.
Topics: Anti-Bacterial Agents; Cholestanes; Cholestanols; Drug Resistance, Bacterial; Gram-Negative Bacteria; Gram-Positive Bacteria; Microbial Sensitivity Tests; Spermine; Structure-Activity Relationship | 2011 |
Protein-tyrosine phosphatase 1B antagonized signaling by insulin-like growth factor-1 receptor and kinase BRK/PTK6 in ovarian cancer cells.
Topics: bcl-Associated Death Protein; Cell Line, Tumor; Cholestanes; Female; Gene Expression Regulation, Neoplastic; Humans; Neoplasm Proteins; Ovarian Neoplasms; Phosphorylation; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein-Tyrosine Kinases; Receptor, IGF Type 1; Signal Transduction; Spermine | 2013 |
The LIM domain only 4 protein is a metabolic responsive inhibitor of protein tyrosine phosphatase 1B that controls hypothalamic leptin signaling.
Topics: Adaptor Proteins, Signal Transducing; Adrenal Glands; Animals; Bacterial Proteins; Blood Pressure; Body Weight; Cell Line, Transformed; Cholestanes; Endoplasmic Reticulum; Glucose Tolerance Test; Homeostasis; Hypothalamus; In Vitro Techniques; Infusions, Intraventricular; Insulin Resistance; Leptin; LIM Domain Proteins; Luminescent Proteins; Mice; Mice, Knockout; Norepinephrine; Pancreas; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Rats; Signal Transduction; Spermine | 2013 |
Targeting the disordered C terminus of PTP1B with an allosteric inhibitor.
Topics: Allosteric Regulation; Allosteric Site; Animals; Antineoplastic Agents; Breast Neoplasms; Catalytic Domain; Cholestanes; Female; Gene Expression Regulation, Neoplastic; Humans; Kinetics; Mammary Neoplasms, Experimental; Mice; Models, Molecular; Molecular Targeted Therapy; Protein Binding; Protein Structure, Secondary; Protein Structure, Tertiary; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Receptor, ErbB-2; Signal Transduction; Spermine | 2014 |
Functional properties of Claramine: a novel PTP1B inhibitor and insulin-mimetic compound.
Topics: Animals; Cells, Cultured; Cholestanes; Diabetes Mellitus, Experimental; Eating; Enzyme Inhibitors; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Insulin; Male; Mice; Mice, Mutant Strains; Neurons; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatase, Non-Receptor Type 2; Proto-Oncogene Proteins c-akt; Receptor, Insulin; Spermine; Weight Loss | 2015 |
Pharmacological inhibition of protein tyrosine phosphatase 1B protects against atherosclerotic plaque formation in the LDLR
Topics: AMP-Activated Protein Kinases; Animals; Aorta; Aortic Diseases; Atherosclerosis; Biomarkers; Blood Glucose; Chemokine CCL2; Cholestanes; Cholesterol; Diet, High-Fat; Disease Models, Animal; Drug Administration Schedule; Enzyme Inhibitors; Genetic Predisposition to Disease; Homeostasis; Male; Mice, Knockout; Phenotype; Phosphorylation; Plaque, Atherosclerotic; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Proto-Oncogene Proteins c-akt; Receptors, LDL; Signal Transduction; Spermine; Time Factors; Triglycerides; Weight Loss | 2017 |
Protein tyrosine phosphatase 1B regulates endothelial endoplasmic reticulum stress; role in endothelial dysfunction.
Topics: Activating Transcription Factor 6; Animals; Cholestanes; eIF-2 Kinase; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Endoribonucleases; Endothelium, Vascular; Enzyme Inhibitors; Heat-Shock Proteins; Male; Mice, Inbred BALB C; Mice, Knockout; Nitric Oxide; Protein Serine-Threonine Kinases; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Signal Transduction; Spermine; Tunicamycin; Vasodilation | 2018 |
Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine.
Topics: alpha-Synuclein; Animals; Caenorhabditis elegans; Cell Line; Cholestanes; Disease Models, Animal; Humans; Neurons; Parkinson Disease; Protein Aggregates; Protein Aggregation, Pathological; Spermine | 2018 |
Trodusquemine enhances Aβ
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Caenorhabditis elegans; Cell Line, Tumor; Cholestanes; Drug Evaluation, Preclinical; Peptide Fragments; Spermine | 2019 |
Neuronal Protein Tyrosine Phosphatase 1B Hastens Amyloid β-Associated Alzheimer's Disease in Mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cholestanes; Disease Models, Animal; Female; Glycogen Synthase Kinase 3 beta; Hippocampus; Humans; Inflammation; Insulin Resistance; Male; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Nerve Tissue Proteins; Peptide Fragments; Plaque, Amyloid; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Recombinant Proteins; Spatial Memory; Spermine | 2020 |
Trodusquemine displaces protein misfolded oligomers from cell membranes and abrogates their cytotoxicity through a generic mechanism.
Topics: alpha-Synuclein; Amyloid beta-Peptides; Biophysical Phenomena; Carboxyl and Carbamoyl Transferases; Cell Death; Cell Line, Tumor; Cell Membrane; Cholestanes; Escherichia coli Proteins; Humans; Protein Folding; Protein Multimerization; Spermine | 2020 |
Making biological membrane resistant to the toxicity of misfolded protein oligomers: a lesson from trodusquemine.
Topics: Cell Membrane; Cholestanes; Lipid Bilayers; Spermine; Unilamellar Liposomes | 2020 |
Ketamine's schizophrenia-like effects are prevented by targeting PTP1B.
Topics: Adaptor Proteins, Signal Transducing; Anesthetics, Dissociative; Animals; Cholestanes; Dose-Response Relationship, Drug; Ketamine; LIM Domain Proteins; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Schizophrenia; Spermine | 2021 |
Tyrosine phosphatase PTP1B impairs presynaptic NMDA receptor-mediated plasticity in a mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Cholestanes; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neuronal Plasticity; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Receptors, N-Methyl-D-Aspartate; Receptors, Presynaptic; Spermine | 2021 |
Quantitative Measurement of the Affinity of Toxic and Nontoxic Misfolded Protein Oligomers for Lipid Bilayers and of its Modulation by Lipid Composition and Trodusquemine.
Topics: Amyloid beta-Peptides; Cholestanes; G(M1) Ganglioside; Lipid Bilayers; Spermine | 2021 |
Studying the trafficking of labeled trodusquemine and its application as nerve marker for light-sheet and expansion microscopy.
Topics: Animals; Cholestanes; Cholesterol; Mice; Microscopy, Fluorescence; Spermine | 2022 |