simvastatin and leptin
simvastatin has been researched along with leptin in 16 studies
Research
Studies (16)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (6.25) | 18.2507 |
| 2000's | 7 (43.75) | 29.6817 |
| 2010's | 6 (37.50) | 24.3611 |
| 2020's | 2 (12.50) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Bartek, J; Růzicka, V; Stejskal, D | 1 |
| Hu, TP; Li, YJ; Luo, JD; Xu, FP | 1 |
| Hellings, N; Hendriks, JJ; Stinissen, P; Vanderlocht, J; Venken, K | 1 |
| Bulcão, C; Ferreira, SR; Giuffrida, FM; Ribeiro-Filho, FF | 1 |
| Berthold, HK; Chamberland, JP; Gouni-Berthold, I; Krone, W; Mantzoros, CS | 1 |
| Han, SH; Kim, SJ; Koh, KK; Lee, Y; Park, JB; Quon, MJ; Shin, EK | 1 |
| Ji, G; Liang, X; Liu, J; Liu, T; Ma, Z; Wu, H; Xin, L; Zheng, P | 1 |
| Horiuchi, N; Maeda, T | 1 |
| Li, J; Luan, Y; Sun, YM; Wang, LF | 1 |
| Andreadi, K; Bellia, A; Cardillo, C; Donadel, G; Fabiano, R; Federici, M; Lauro, D; Lombardo, MF; Quon, MJ; Rizza, S; Sbraccia, P; Tesauro, M | 1 |
| Han, W; Li, J; Sun, L; Tang, H | 1 |
| Abd El Aal, HA; Ahmed, LA; Fawzy, HM; Hassan, WA; Moawad, H | 1 |
| Covassin, N; Friedman, PA; Sharma, P; Singh, P; Somers, VK; Soucek, F; Zhang, Y | 1 |
| Dandanell, S; Dela, F; Helge, JW; Larsen, S; Prats, C; Vigelsø, A | 1 |
| Du, J; Jiang, Q; Li, H; Lin, S; Mei, L; Wen, J; Yang, R | 1 |
| Abdelfattah, MS; Aldin, DE; Aleid, GM; Fareid, MA; Hameed, RA; Khaled, AM; Moneim, AEA; Othman, MS | 1 |
Trials
5 trial(s) available for simvastatin and leptin
| Article | Year |
|---|---|
[Serum leptin, early atherosclerosis and hypolipidemia (a new, previously undescribed effect of pravastatin, a hypolipemic agent)].
Topics: Adipose Tissue; Age of Onset; Arteriosclerosis; Body Mass Index; Female; Fenofibrate; Humans; Hypolipidemic Agents; Insulin; Leptin; Male; Middle Aged; Pravastatin; Proteins; Simvastatin | 1998 |
Are the beneficial cardiovascular effects of simvastatin and metformin also associated with a hormone-dependent mechanism improving insulin sensitivity?
Topics: Adiponectin; Adolescent; Adult; Aged; Anticholesteremic Agents; Body Mass Index; C-Reactive Protein; Cardiovascular Diseases; Female; Humans; Hypoglycemic Agents; Leptin; Male; Metabolic Syndrome; Metformin; Middle Aged; Simvastatin | 2007 |
Short-term treatment with ezetimibe, simvastatin or their combination does not alter circulating adiponectin, resistin or leptin levels in healthy men.
Topics: Adiponectin; Adolescent; Adult; Anticholesteremic Agents; Azetidines; Drug Therapy, Combination; Ezetimibe; Humans; Leptin; Male; Middle Aged; Resistin; Simvastatin; Time Factors | 2008 |
Differential metabolic effects of pravastatin and simvastatin in hypercholesterolemic patients.
Topics: Adiponectin; C-Reactive Protein; Double-Blind Method; Endothelium, Vascular; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Insulin; Insulin Resistance; Leptin; Lipoproteins; Male; Middle Aged; Pravastatin; Simvastatin; Treatment Outcome; Vasodilation | 2009 |
Deterioration of glucose homeostasis in type 2 diabetic patients one year after beginning of statins therapy.
Topics: Adiponectin; Biomarkers; Blood Glucose; Brachial Artery; C-Reactive Protein; Chi-Square Distribution; Cross-Over Studies; Diabetes Mellitus, Type 2; Endothelium, Vascular; Female; Fluorobenzenes; Glucose Clamp Technique; Glycated Hemoglobin; Homeostasis; Hospitals, University; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemic Agents; Insulin; Insulin Resistance; Insulin Secretion; Insulin-Secreting Cells; Leptin; Lipids; Male; Middle Aged; Pyrimidines; Rome; Rosuvastatin Calcium; Simvastatin; Single-Blind Method; Sulfonamides; Time Factors; Treatment Outcome; Tumor Necrosis Factor-alpha | 2012 |
Other Studies
11 other study(ies) available for simvastatin and leptin
| Article | Year |
|---|---|
Simvastatin inhibits leptin-induced hypertrophy in cultured neonatal rat cardiomyocytes.
Topics: Animals; Animals, Newborn; Antioxidants; Butylated Hydroxyanisole; Catalase; Cell Size; Cells, Cultured; Leptin; Myocytes, Cardiac; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; RNA; Simvastatin | 2006 |
Effects of IFN-beta, leptin and simvastatin on LIF secretion by T lymphocytes of MS patients and healthy controls.
Topics: Adult; Aged; CD4-Positive T-Lymphocytes; Cells, Cultured; Cytokines; Cytoprotection; Down-Regulation; Female; Humans; Interferon-beta; Interleukin-6; Leptin; Leukemia Inhibitory Factor; Male; Middle Aged; Multiple Sclerosis; Neuroprotective Agents; Reference Values; Simvastatin; T-Lymphocytes; Up-Regulation | 2006 |
Therapeutic effect of puerarin on non-alcoholic rat fatty liver by improving leptin signal transduction through JAK2/STAT3 pathways.
Topics: Animals; Cholesterol; Dietary Fats; Disease Models, Animal; Dose-Response Relationship, Drug; Fatty Liver; Inflammation; Isoflavones; Janus Kinase 2; Leptin; Lipid Metabolism; Liver; Male; Phytotherapy; Plant Extracts; Pueraria; Rats; Rats, Wistar; Receptors, Leptin; RNA, Messenger; Signal Transduction; Simvastatin; STAT3 Transcription Factor; Triglycerides | 2009 |
Simvastatin suppresses leptin expression in 3T3-L1 adipocytes via activation of the cyclic AMP-PKA pathway induced by inhibition of protein prenylation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3T3-L1 Cells; Adipocytes; Androstadienes; Animals; Benzamides; Cell Differentiation; Chromones; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cycloheximide; Enzyme-Linked Immunosorbent Assay; Gene Expression; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Isoquinolines; Leptin; Methionine; Mevalonic Acid; Mice; Morpholines; Polyisoprenyl Phosphates; Protein Prenylation; Protein Synthesis Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Simvastatin; Sulfonamides; Wortmannin | 2009 |
Effect of statin therapy on leptin levels in patients with coronary heart disease.
Topics: Aged; Coronary Disease; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Leptin; Lipids; Male; Middle Aged; Nitric Oxide; Simvastatin | 2010 |
Treatment of obese asthma in a mouse model by simvastatin is associated with improving dyslipidemia and decreasing leptin level.
Topics: Animals; Asthma; Blood Glucose; Body Weight; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Dyslipidemias; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Leptin; Leukocyte Count; Lipids; Lung; Mice; Mice, Inbred C57BL; Obesity; Simvastatin | 2017 |
Combination of carvacrol with simvastatin improves the lipid-lowering efficacy and alleviates simvastatin side effects.
Topics: Adiponectin; Animals; Anticholesteremic Agents; Caspase 3; Catalase; Cholesterol; Cymenes; Drug Combinations; Drug Evaluation, Preclinical; Drug Synergism; Glutathione; Hypercholesterolemia; Leptin; Liver; Male; Monoterpenes; Muscle, Skeletal; Organ Size; Rats, Sprague-Dawley; Simvastatin; Triglycerides | 2017 |
Statins decrease leptin expression in human white adipocytes.
Topics: Adipocytes, White; Adiponectin; Atorvastatin; Cells, Cultured; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Leptin; Simvastatin | 2018 |
Simvastatin-Induced Insulin Resistance May Be Linked to Decreased Lipid Uptake and Lipid Synthesis in Human Skeletal Muscle: the LIFESTAT Study.
Topics: Adiponectin; Adult; Blood Glucose; Glucose Tolerance Test; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Insulin Resistance; Leptin; Lipid Metabolism; Male; Middle Aged; Muscle, Skeletal; Simvastatin | 2018 |
Effect of high fat diet and excessive compressive mechanical force on pathologic changes of temporomandibular joint.
Topics: Animals; Chondrocytes; Diet, High-Fat; Disease Models, Animal; Interleukin-1beta; Leptin; Male; Mandible; Matrix Metalloproteinase 3; Mice; Mice, Inbred C57BL; Obesity; Phenazines; Risk Factors; Simvastatin; Stress, Mechanical; Temporomandibular Joint | 2020 |
Evaluation of antiobesity and hepatorenal protective activities of Salvia officinalis extracts pre-treatment in high-fat diet-induced obese rats.
Topics: Animals; Antioxidants; Biomarkers; Body Weight; Creatinine; Diet, High-Fat; Flavonoids; Inflammation Mediators; Insulins; Interleukin-1beta; Leptin; Lipids; NF-E2-Related Factor 2; Nitric Oxide; Obesity; Oxidative Stress; Plant Extracts; PPAR gamma; Rats; Salvia officinalis; Simvastatin; Superoxide Dismutase; Tumor Necrosis Factor-alpha; Urea | 2022 |