Compounds > serine

serine and pd 98059

serine has been researched along with pd 98059 in 81 studies

Research

Studies (81)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's20 (24.69)18.2507
2000's53 (65.43)29.6817
2010's8 (9.88)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Mothe, I; Van Obberghen, E1
Kamino, K; Miki, T; Nishiwaki, Y; Ogihara, T; Sato, N; Satoh, T; Tateishi, K; Yoshiiwa, A1
Baker, KM; Bhat, GJ1
DaSilva, L; Erwin, RA; Farrar, WL; Hennighausen, L; Kirken, RA; Liu, X; Malabarba, MG; Rui, H; Xu, J1
Cohen, P; Haavik, J; Thomas, G1
Ceresa, BP; Horvath, CM; Pessin, JE1
Dong, LQ; Du, H; Fan, J; Kolakowski, LF; Lee, AV; Liu, F; Mandarino, J; Mandarino, LJ; Porter, SG; Yee, D1
Avruch, J; Caudwell, FB; Cohen, P; Dalby, KN; Morrice, N1
Badalian, T; Fisher, DE; Hemesath, TJ; Price, ER; Takemoto, C1
Burt, JM; Cottrell, GT; Lau, AF; Warn-Cramer, BJ1
Bassini, A; Bertolaso, L; Capitani, S; Gibellini, D; La Placa, M; Milani, D; Pierpaoli, S; Zauli, G1
Auer, KL; Birrer, M; Carter, S; Dent, P; Fisher, PB; Mikkelsen, R; Reardon, DB; Schmidt-Ullrich, R; Valerie, K1
Bassini, A; Capitani, S; Celeghini, C; Gibellini, D; Guidotti, L; Marchisio, M; Pierpaoli, S; Secchiero, P; Vitale, M; Zauli, G1
Dong, Z; Huang, C; Ma, WY; Maxiner, A; Sun, Y1
Abe, J; Aebersold, R; Berk, BC; Gallis, B; Krebs, EG; Spring, DJ; Takahashi, E1
Johansen, B; Moens, U; Seternes, OM1
Cao, X; Lim, CP1
Duronio, V; Scheid, MP; Schubert, KM1
Caput, D; Escoubet, L; Ferrara, P; Pipy, B; Quartulli, F; Rey, A; Sozzani, P1
Campbell, DH; Daly, RJ; Sutherland, RL1
Bradshaw, RA; Wu, YY1
Chen, N; Dong, Z; She, QB1
Dong, Z; Ma, WY; Zhong, SP1
Kleijn, M; Proud, CG1
Codogno, P; El Benna, J; Ogier-Denis, E; Pattingre, S1
Kar, S; Quirion, R; Zheng, WH1
Horwitz, SB; Yang, CP1
Beale, G; Cross, J; England, K; Rumsby, M; Warner, M; Watson, J1
Choi, SL; Choi, YK; Ha, J; Kang, I; Kim, J; Kim, SS; Kim, YS; Yoon, MY1
Dong, Z; Goto, H; Inagaki, M; Jansen, C; Zhang, Y; Zhong, S1
Arnold, FJ; Bading, H; Hardingham, GE1
Abe, K; Higashi, N; Hirai, M; Hirano, T; Miki, T; Mizuno, K; Nakajima, K; Sekimoto, T1
Castranova, V; Ding, M; Huang, C; Leonard, SS; Li, J; Shi, X; Vallyathan, V; Wang, L1
Greenberg, AS; Kraemer, FB; Muliro, K; Patel, S; Roth, RA; Shen, WJ; Souza, SC1
Geum, D; Kim, K; Son, GH1
Hashiba, Y; Hashimoto, K; Kohga, H; Monden, T; Mori, M; Ozawa, A; Sasaki, T; Satoh, T; Yamada, M1
Abello, J; Chayvialle, JA; Cordier-Bussat, M; Gevrey, JC; Némoz-Gaillard, E1
Ajima, R; K-Tsuzuku, J; Nakamura, T; Suzuki, T; Yamamoto, T; Yoshida, Y1
Deng, X; Gao, F; Jin, Z; Mai, H; May, WS1
Evert, BO; Klockgether, T; Schwarz, CS; Seyfried, J; Wüllner, U1
Bode, AM; Dong, Z; He, Z; Liu, G; Ma, WY; Zhang, Y1
De Wilde, G; Haegeman, G; Van Damme, P; Vanden Berghe, W; Vermeulen, L1
Abe, J; Akaike, M; Cameron, SJ; Lee, JD; Lerner-Marmarosh, N; Malik, S; Yan, C; Yang, J1
Coss, D; Kuo, CB; Lorenson, MY; Walker, AM; Wu, W; Xu, X1
Calderwood, SK; Grammatikakis, N; Siganou, A; Wang, X1
Katada, T; Kontani, K; Kurosu, H; Momose, H; Nishina, H; Tsujimoto, N; Tsujita, K1
Ito, F; Takeuchi, K1
Adeyinka, A; Cherlet, T; Murphy, L; Niu, Y; Snell, L; Watson, P1
Chen, C; Sytkowski, AJ1
Davis, FB; Davis, PJ; Lin, HY; Tang, HY; Zhang, S1
Garnovskaya, MN; Grewal, JS; Mukhin, YV; Raymond, JR; Tholanikunnel, BG; Ullian, ME; Vlasova, TM1
Cheng, AL; Chuang, SE; Song, YC; Yeh, KH; Yeh, PY1
An, W; Tian, ZJ1
Ben-Ze'ev, A; Kosakowski, M; Lee, P; Libertino, JA; Moinzadeh, A; Rieger-Christ, KM; Stoffel, J; Summerhayes, IC; Zagha, R1
Chang, NS; Heath, J; Hsu, LJ; Jambal, P; Pugazhenthi, S; Schultz, L; Su, M; Sze, CI1
Bode, AM; Cho, YY; Choi, BY; Choi, HS; Dong, Z; Zhu, F1
Akamastu, S; Ishisaki, A; Kanno, Y; Kato, K; Kitajima, Y; Kozawa, O; Matsuno, H; Nakajima, K; Shu, E; Suga, H; Takai, S1
Gibson, RM; Laszlo, GS; Nathanson, NM1
Harada, C; Harada, T; Kase, S; Nakayama, KI; Namekata, K; Ohgami, K; Ohno, S; Shiratori, K; Suzuki, Y; Yoshida, K1
Billestrup, N; Bonny, C; Darville, M; Eizirik, DL; Larsen, L; Mandrup-Poulsen, T; Størling, J1
Avila, J; Corominola, H; Domínguez, J; Gómez-Ramos, A; Gomis, R; Guinovart, JJ; Zafra, D1
Lee, CT; Lee, EH; Ma, YL; Tsai, MC; Tyan, SW; Yang, YC1
Beis, I; Gaitanaki, C; Kefaloyianni, E1
Chen, RJ; Cowart, LA; Jiang, JG; Wang, DW; Wang, JN; Wang, Y; Xia, Y; Xiao, B; Xiao, X; Yang, S1
Asano, T; Atsuzawa, K; Deguchi, T; Ito, H; Iwamoto, I; Katoh-Semba, R; Mizutani, K; Morishita, R; Nagata, K; Nozawa, Y; Sudo, K; Usuda, N1
Lee, YJ; Shukla, SD1
Albert, PR; Bulman, DE; Daigle, M; Grimes, DA; Jacobsen, KX; Lemonde, S; MacDonald, H1
Paakkunainen, M; Silvennoinen, O; Ungureanu, D; Vanhatupa, S1
Li, XJ; Li, YH; Lin, YH; Su, TH; Tie, L; Wu, HL; Yu, HM; Zhang, JZ; Zhang, YY1
Goda, T; Mochizuki, K; Takabe, S1
Graves, PR; Sankala, H; Zeng, Y; Zhang, X1
Ballim, RD; Mowla, S; Prince, S; Teng, H1
Bergeron, JJ; Cameron, PH; Chevet, E; Pluquet, O; Thomas, DY1
Bae, YS; Jung, HY; Kim, J; Oh, H1
Blandino, G; Marani, M; Muti, P; Santoro, R; Strano, S1
Albers, C; Bassermann, F; Duyster, J; Illert, AL; Kreutmair, S; Moll, C; Peschel, C; Zech, M1
Kim, S; Lee, CH; Lee, HJ; Park, MK; Park, Y; Shim, J1
Curcio, F; Ferro, F; Spelat, R1
Kasahara, S; Kato, K; Kozawa, O; Matsushima-Nishiwaki, R; Mizuno, T; Sakakibara, S; Tokuda, H1
Cen, G; Ding, HH; Liu, B; Wu, WD1
Liu, ZX; Luo, WW; Ma, D; Ma, SM; Su, Q; Sun, Y; Wang, CY; Wen, JK; Yang, YZ; Yang, Z; Zhang, XH; Zheng, B1

Other Studies

81 other study(ies) available for serine and pd 98059

ArticleYear
Phosphorylation of insulin receptor substrate-1 on multiple serine residues, 612, 632, 662, and 731, modulates insulin action.
    The Journal of biological chemistry, 1996, May-10, Volume: 271, Issue:19

    Topics: Amino Acid Sequence; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Cloning, Molecular; Enzyme Inhibitors; Ethers, Cyclic; Flavonoids; Humans; Insulin; Insulin Receptor Substrate Proteins; Molecular Sequence Data; Okadaic Acid; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Point Mutation; Rats; Recombinant Proteins; Serine; Threonine; Transfection

1996
Elevated amyloid beta protein(1-40) level induces CREB phosphorylation at serine-133 via p44/42 MAP kinase (Erk1/2)-dependent pathway in rat pheochromocytoma PC12 cells.
    Biochemical and biophysical research communications, 1997, Mar-27, Volume: 232, Issue:3

    Topics: Amyloid beta-Peptides; Animals; Binding Sites; Calcium-Calmodulin-Dependent Protein Kinases; Cyclic AMP Response Element-Binding Protein; Enzyme Inhibitors; Flavonoids; Kinetics; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; PC12 Cells; Peptide Fragments; Phosphorylation; Protein-Tyrosine Kinases; Rats; Serine

1997
Angiotensin II stimulates rapid serine phosphorylation of transcription factor Stat3.
    Molecular and cellular biochemistry, 1997, Volume: 170, Issue:1-2

    Topics: Angiotensin I; Angiotensin II; Animals; Animals, Newborn; CHO Cells; Cricetinae; DNA-Binding Proteins; Enzyme Inhibitors; Fibroblasts; Flavonoids; Kinetics; Mitogen-Activated Protein Kinase Kinases; Myocardium; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinase Inhibitors; Rats; Receptors, Angiotensin; Recombinant Proteins; Serine; STAT3 Transcription Factor; Trans-Activators; Transcription Factors; Transfection

1997
Two discrete regions of interleukin-2 (IL2) receptor beta independently mediate IL2 activation of a PD98059/rapamycin/wortmannin-insensitive Stat5a/b serine kinase.
    The Journal of biological chemistry, 1997, Jun-13, Volume: 272, Issue:24

    Topics: Androstadienes; Animals; Cells, Cultured; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Interleukin-2; Kinetics; Phosphorylation; Polyenes; Protein Serine-Threonine Kinases; Rats; Receptors, Interleukin-2; Serine; Sirolimus; Tumor Cells, Cultured; Tyrosine; Wortmannin

1997
Participation of a stress-activated protein kinase cascade in the activation of tyrosine hydroxylase in chromaffin cells.
    European journal of biochemistry, 1997, Aug-01, Volume: 247, Issue:3

    Topics: Adrenal Glands; Animals; Arsenites; Calcium-Calmodulin-Dependent Protein Kinases; Cattle; Chromaffin Cells; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Imidazoles; Intracellular Signaling Peptides and Proteins; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; PC12 Cells; Phosphorylation; Protein Serine-Threonine Kinases; Pyridines; Rats; Serine; Tyrosine 3-Monooxygenase

1997
Signal transducer and activator of transcription-3 serine phosphorylation by insulin is mediated by a Ras/Raf/MEK-dependent pathway.
    Endocrinology, 1997, Volume: 138, Issue:10

    Topics: Animals; Anisomycin; Anti-Bacterial Agents; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; CHO Cells; Cricetinae; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Insulin; Interleukin-6; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase Kinases; Mutation; Phosphorylation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; ras Proteins; Serine; STAT3 Transcription Factor; Trans-Activators; Transfection; Tyrosine

1997
Cloning, chromosome localization, expression, and characterization of an Src homology 2 and pleckstrin homology domain-containing insulin receptor binding protein hGrb10gamma.
    The Journal of biological chemistry, 1997, Nov-14, Volume: 272, Issue:46

    Topics: Amino Acid Sequence; Androstadienes; Chromosome Mapping; Chromosomes, Human, Pair 17; Chromosomes, Human, Pair 7; Cloning, Molecular; DNA, Complementary; Enzyme Inhibitors; Flavonoids; GRB10 Adaptor Protein; Humans; Insulin; Molecular Sequence Data; Phosphorylation; Protein Binding; Proteins; Receptor, Insulin; Sequence Homology, Amino Acid; Serine; Signal Transduction; src Homology Domains; Wortmannin

1997
Identification of regulatory phosphorylation sites in mitogen-activated protein kinase (MAPK)-activated protein kinase-1a/p90rsk that are inducible by MAPK.
    The Journal of biological chemistry, 1998, Jan-16, Volume: 273, Issue:3

    Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Calcium-Calmodulin-Dependent Protein Kinases; COS Cells; Enzyme Induction; Enzyme Inhibitors; Flavonoids; Humans; Molecular Sequence Data; Mutagenesis, Site-Directed; Peptide Mapping; Phosphorylation; Protein Serine-Threonine Kinases; Ribosomal Protein S6 Kinases; Ribosomal Protein S6 Kinases, 90-kDa; Serine; Tetradecanoylphorbol Acetate; Threonine

1998
MAP kinase links the transcription factor Microphthalmia to c-Kit signalling in melanocytes.
    Nature, 1998, Jan-15, Volume: 391, Issue:6664

    Topics: Calcium-Calmodulin-Dependent Protein Kinases; DNA-Binding Proteins; Enzyme Inhibitors; Flavonoids; Humans; MAP Kinase Kinase Kinase 1; Melanocytes; Microphthalmia-Associated Transcription Factor; Mutagenesis, Site-Directed; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-kit; Serine; Signal Transduction; Transcription Factors; Tumor Cells, Cultured

1998
Regulation of connexin-43 gap junctional intercellular communication by mitogen-activated protein kinase.
    The Journal of biological chemistry, 1998, Apr-10, Volume: 273, Issue:15

    Topics: Animals; Binding Sites; Calcium-Calmodulin-Dependent Protein Kinases; Cell Communication; Cell Line; Connexin 43; Enzyme Inhibitors; Epidermal Growth Factor; Flavonoids; Gap Junctions; HeLa Cells; Humans; Kinetics; Lysophospholipids; Mice; Mice, Knockout; Models, Biological; Phosphorylation; Rats; Recombinant Proteins; Serine; Signal Transduction; Transfection

1998
Extracellular HIV-1 Tat protein induces the rapid Ser133 phosphorylation and activation of CREB transcription factor in both Jurkat lymphoblastoid T cells and primary peripheral blood mononuclear cells.
    Journal of immunology (Baltimore, Md. : 1950), 1998, Apr-15, Volume: 160, Issue:8

    Topics: Base Sequence; Binding Sites; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Chloramphenicol O-Acetyltransferase; Cyclic AMP Response Element-Binding Protein; DNA; Enzyme Inhibitors; Flavonoids; Gene Products, tat; Genes, Reporter; HIV-1; Humans; Jurkat Cells; Leukocytes, Mononuclear; Phosphorylation; Serine; Signal Transduction; Staurosporine; tat Gene Products, Human Immunodeficiency Virus; Transfection

1998
Inhibition of the mitogen activated protein (MAP) kinase cascade potentiates cell killing by low dose ionizing radiation in A431 human squamous carcinoma cells.
    Oncogene, 1998, May-28, Volume: 16, Issue:21

    Topics: Amino Acid Sequence; Calcium-Calmodulin-Dependent Protein Kinases; Carcinoma, Squamous Cell; Cell Death; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; DNA Damage; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Molecular Sequence Data; Phosphorylation; Radiation Dosage; Radiation, Ionizing; Serine; Signal Transduction; Tumor Cells, Cultured

1998
The induction of megakaryocyte differentiation is accompanied by selective Ser133 phosphorylation of the transcription factor CREB in both HEL cell line and primary CD34+ cells.
    Blood, 1998, Jul-15, Volume: 92, Issue:2

    Topics: Antigens, CD34; Blotting, Western; Cell Differentiation; Cell Line; Cyclic AMP Response Element-Binding Protein; Enzyme Inhibitors; Flavonoids; Flow Cytometry; Hematopoietic Stem Cells; Humans; Megakaryocytes; Phosphorylation; Protein Kinase Inhibitors; Protein Kinases; Serine; Signal Transduction; Thrombopoietin

1998
p38 kinase mediates UV-induced phosphorylation of p53 protein at serine 389.
    The Journal of biological chemistry, 1999, Apr-30, Volume: 274, Issue:18

    Topics: Antibodies, Monoclonal; Base Sequence; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; DNA Primers; Enzyme Inhibitors; Flavonoids; Imidazoles; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Precipitin Tests; Pyridines; Serine; Transcription, Genetic; Tumor Suppressor Protein p53; Ultraviolet Rays

1999
p90(RSK) is a serum-stimulated Na+/H+ exchanger isoform-1 kinase. Regulatory phosphorylation of serine 703 of Na+/H+ exchanger isoform-1.
    The Journal of biological chemistry, 1999, Jul-16, Volume: 274, Issue:29

    Topics: Amino Acid Sequence; Animals; Base Sequence; Blood; Cells, Cultured; DNA Primers; DNA, Complementary; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Male; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase Kinases; Mutagenesis, Site-Directed; Peptide Mapping; Phosphorylation; Precipitin Tests; Protein Isoforms; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Ribosomal Protein S6 Kinases; Serine; Sodium-Hydrogen Exchangers; Thrombin; Transfection

1999
A dominant role for the Raf-MEK pathway in forskolin, 12-O-tetradecanoyl-phorbol acetate, and platelet-derived growth factor-induced CREB (cAMP-responsive element-binding protein) activation, uncoupled from serine 133 phosphorylation in NIH 3T3 cells.
    Molecular endocrinology (Baltimore, Md.), 1999, Volume: 13, Issue:7

    Topics: 3T3 Cells; Amino Acid Sequence; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Cycle Proteins; Colforsin; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; DNA-Binding Proteins; Dual Specificity Phosphatase 1; Dual Specificity Phosphatase 6; Enzyme Activation; Enzyme Inhibitors; ets-Domain Protein Elk-1; Flavonoids; Immediate-Early Proteins; MAP Kinase Kinase Kinase 1; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Molecular Sequence Data; Phosphoprotein Phosphatases; Phosphorylation; Platelet-Derived Growth Factor; Protein Kinase C; Protein Phosphatase 1; Protein Serine-Threonine Kinases; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Serine; Tetradecanoylphorbol Acetate; Transcription Factors; Transcriptional Activation

1999
Serine phosphorylation and negative regulation of Stat3 by JNK.
    The Journal of biological chemistry, 1999, Oct-22, Volume: 274, Issue:43

    Topics: Amino Acid Substitution; Animals; COS Cells; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Flavonoids; Gene Expression Regulation; Imidazoles; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; Mutagenesis, Site-Directed; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Phosphoserine; Point Mutation; Pyridines; Recombinant Fusion Proteins; Serine; Signal Transduction; STAT3 Transcription Factor; Trans-Activators; Transfection; Ultraviolet Rays

1999
Regulation of bad phosphorylation and association with Bcl-x(L) by the MAPK/Erk kinase.
    The Journal of biological chemistry, 1999, Oct-22, Volume: 274, Issue:43

    Topics: Apoptosis; bcl-Associated Death Protein; bcl-X Protein; Carrier Proteins; Cell Death; Cell Line; Enzyme Inhibitors; Flavonoids; Homeostasis; Humans; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Peptide Mapping; Phosphopeptides; Phosphorylation; Phosphoserine; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Serine; Substrate Specificity

1999
IL-13 induces serine phosphorylation of cPLA2 in mouse peritoneal macrophages leading to arachidonic acid and PGE2 production and blocks the zymosan-induced serine phosphorylation of cPLA2 and eicosanoid production.
    Biochimica et biophysica acta, 1999, Sep-22, Volume: 1440, Issue:2-3

    Topics: Animals; Arachidonic Acid; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cytosol; Dinoprostone; Female; Flavonoids; Interleukin-13; Lipoxygenase; Macrophages, Peritoneal; Mice; Phospholipases A; Phosphorylation; Precipitin Tests; Prostaglandin-Endoperoxide Synthases; Serine; Signal Transduction; Zymosan

1999
Signaling pathways and structural domains required for phosphorylation of EMS1/cortactin.
    Cancer research, 1999, Oct-15, Volume: 59, Issue:20

    Topics: Cell Adhesion; Cells, Cultured; Cortactin; Epidermal Growth Factor; Flavonoids; Humans; MAP Kinase Kinase Kinase 1; MAP Kinase Kinase Kinases; Microfilament Proteins; Neoplasm Proteins; Phosphorylation; Protein Serine-Threonine Kinases; Serine; src Homology Domains; Structure-Activity Relationship; Threonine

1999
Activation of the Stat3 signaling pathway is required for differentiation by interleukin-6 in PC12-E2 cells.
    The Journal of biological chemistry, 2000, Jan-21, Volume: 275, Issue:3

    Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; Cell Differentiation; Cell Line; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Genes, Dominant; Humans; Interferon-gamma; Interleukin-6; Mutagenesis, Site-Directed; Nerve Growth Factors; Neurites; PC12 Cells; Phosphorylation; Proteins; Proto-Oncogene Proteins p21(ras); Rats; Serine; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; STAT1 Transcription Factor; STAT3 Transcription Factor; Time Factors; Trans-Activators; Tyrosine

2000
ERKs and p38 kinase phosphorylate p53 protein at serine 15 in response to UV radiation.
    The Journal of biological chemistry, 2000, Jul-07, Volume: 275, Issue:27

    Topics: Animals; Cell Line; Enzyme Inhibitors; Flavonoids; Imidazoles; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Mutation; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Serine; Tumor Suppressor Protein p53; Ultraviolet Rays

2000
ERKs and p38 kinases mediate ultraviolet B-induced phosphorylation of histone H3 at serine 10.
    The Journal of biological chemistry, 2000, Jul-14, Volume: 275, Issue:28

    Topics: Animals; Cell Line; Enzyme Inhibitors; Flavonoids; Histones; Imidazoles; Kinetics; MAP Kinase Kinase 1; Mice; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinase 9; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Phosphoserine; Protein Serine-Threonine Kinases; Pyridines; Serine; Ultraviolet Rays

2000
The activation of eukaryotic initiation factor (eIF)2B by growth factors in PC12 cells requires MEK/ERK signalling.
    FEBS letters, 2000, Jul-07, Volume: 476, Issue:3

    Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Inhibitors; Epidermal Growth Factor; Eukaryotic Initiation Factor-2B; Flavonoids; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; Kinetics; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Nerve Growth Factor; PC12 Cells; Phosphorylation; Rats; Serine; Signal Transduction

2000
Erk1/2-dependent phosphorylation of Galpha-interacting protein stimulates its GTPase accelerating activity and autophagy in human colon cancer cells.
    The Journal of biological chemistry, 2000, Dec-15, Volume: 275, Issue:50

    Topics: Alanine; Casein Kinase II; Colonic Neoplasms; Enzyme Inhibitors; Flavonoids; GTP Phosphohydrolases; Humans; Immunoblotting; Indoles; Kinetics; Maleimides; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Mutagenesis, Site-Directed; Phosphoproteins; Phosphorylation; Precipitin Tests; Protein Kinase C; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; RGS Proteins; Serine; Signal Transduction; Transfection; Tumor Cells, Cultured

2000
Insulin-like growth factor-1-induced phosphorylation of the forkhead family transcription factor FKHRL1 is mediated by Akt kinase in PC12 cells.
    The Journal of biological chemistry, 2000, Dec-15, Volume: 275, Issue:50

    Topics: 3T3 Cells; Androstadienes; Animals; Apoptosis; Blotting, Western; Cell Line; Cells, Cultured; Cerebellum; Cerebral Cortex; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Forkhead Box Protein O1; Forkhead Box Protein O3; Forkhead Transcription Factors; Humans; Insulin-Like Growth Factor I; Mice; Mutagenesis; Myristic Acid; Nerve Tissue Proteins; Neurons; PC12 Cells; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Precipitin Tests; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Ribosomal Protein S6 Kinases; Serine; Sirolimus; Threonine; Transcription Factors; Transfection; Vanadates; Wortmannin

2000
Taxol mediates serine phosphorylation of the 66-kDa Shc isoform.
    Cancer research, 2000, Sep-15, Volume: 60, Issue:18

    Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Antineoplastic Agents, Phytogenic; Carcinoma; Cyanogen Bromide; Cycloheximide; Drug Interactions; Drug Resistance, Neoplasm; Electrophoresis, Gel, Two-Dimensional; Enzyme Inhibitors; Flavonoids; Humans; Lung Neoplasms; MAP Kinase Kinase Kinases; Microtubules; Paclitaxel; Peptide Fragments; Phosphorylation; Protein Isoforms; Protein Structure, Tertiary; Protein Synthesis Inhibitors; Proteins; Proto-Oncogene Proteins c-raf; Serine; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; Tumor Cells, Cultured; Tyrosine

2000
Signalling pathways regulating the dephosphorylation of Ser729 in the hydrophobic domain of protein kinase Cepsilon upon cell passage.
    The Journal of biological chemistry, 2001, Mar-30, Volume: 276, Issue:13

    Topics: 3T3 Cells; Alkaloids; Animals; Anti-Bacterial Agents; Benzophenanthridines; Blotting, Western; Calcineurin; Cell Adhesion; Cell Line; Culture Media; Cyclosporine; Down-Regulation; Enzyme Inhibitors; Flavonoids; Indoles; Isoenzymes; MAP Kinase Signaling System; Marine Toxins; Methionine; Mice; Models, Biological; Okadaic Acid; Oxazoles; Phenanthridines; Phosphoprotein Phosphatases; Phosphorylation; Plasmids; Precipitin Tests; Protein Binding; Protein Kinase C; Protein Kinase C-epsilon; Protein Structure, Tertiary; Serine; Signal Transduction; Sirolimus; Tacrolimus; Transfection

2001
Effects of stimulation of AMP-activated protein kinase on insulin-like growth factor 1- and epidermal growth factor-dependent extracellular signal-regulated kinase pathway.
    The Journal of biological chemistry, 2001, Jun-01, Volume: 276, Issue:22

    Topics: 3T3 Cells; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Catalysis; Cell Line; Colforsin; COS Cells; DNA; DNA, Complementary; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Flavonoids; Insulin-Like Growth Factor I; Mice; Mitogen-Activated Protein Kinases; Multienzyme Complexes; Phosphorylation; Protein Binding; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-raf; Ribonucleotides; RNA; RNA, Antisense; Serine; Signal Transduction; Time Factors; Transfection

2001
MAP kinases mediate UVB-induced phosphorylation of histone H3 at serine 28.
    The Journal of biological chemistry, 2001, Apr-20, Volume: 276, Issue:16

    Topics: Animals; Cell Line; Chromatin; Enzyme Inhibitors; Flavonoids; Histones; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinase 9; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Serine

2001
A calcium microdomain near NMDA receptors: on switch for ERK-dependent synapse-to-nucleus communication.
    Nature neuroscience, 2001, Volume: 4, Issue:6

    Topics: Action Potentials; Animals; Bicuculline; Binding Sites; Calcium; Calcium Signaling; Cell Nucleus; Cells, Cultured; Cyclic AMP Response Element-Binding Protein; Egtazic Acid; Electric Stimulation; Enzyme Inhibitors; Flavonoids; Hippocampus; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neurons; Phosphorylation; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Serine; Signal Transduction; Synapses

2001
The YXXQ motif in gp 130 is crucial for STAT3 phosphorylation at Ser727 through an H7-sensitive kinase pathway.
    Oncogene, 2001, Jun-14, Volume: 20, Issue:27

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3T3 Cells; Alanine; Amino Acid Sequence; Amino Acid Substitution; Animals; Antigens, CD; Binding Sites; Carcinoma, Hepatocellular; Cell Line; Cytokine Receptor gp130; DNA Primers; DNA-Binding Proteins; Enzyme Inhibitors; Flavonoids; Granulocyte Colony-Stimulating Factor; Humans; Interferon-gamma; Interleukin-6; Liver Neoplasms; Membrane Glycoproteins; Mice; Mitogen-Activated Protein Kinases; Molecular Sequence Data; Mutagenesis, Site-Directed; Phosphorylation; Protein Kinases; Recombinant Fusion Proteins; Recombinant Proteins; Serine; Signal Transduction; STAT3 Transcription Factor; Tetradecanoylphorbol Acetate; Trans-Activators; Transfection; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha

2001
UV Induces phosphorylation of protein kinase B (Akt) at Ser-473 and Thr-308 in mouse epidermal Cl 41 cells through hydrogen peroxide.
    The Journal of biological chemistry, 2001, Oct-26, Volume: 276, Issue:43

    Topics: Animals; Epidermal Cells; Epidermis; Flavonoids; Free Radical Scavengers; Hydrogen Peroxide; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Serine; Threonine; Ultraviolet Rays

2001
Stimulation of lipolysis and hormone-sensitive lipase via the extracellular signal-regulated kinase pathway.
    The Journal of biological chemistry, 2001, Nov-30, Volume: 276, Issue:48

    Topics: 3T3 Cells; Animals; Binding Sites; Cell Differentiation; CHO Cells; Cricetinae; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Immunoblotting; Isoproterenol; Lipolysis; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinases; Mutagenesis, Site-Directed; Phosphorylation; Plasmids; Serine; Signal Transduction; Sterol Esterase; Tamoxifen; Time Factors; Transfection

2001
Phosphorylation-dependent cellular localization and thermoprotective role of heat shock protein 25 in hippocampal progenitor cells.
    The Journal of biological chemistry, 2002, May-31, Volume: 277, Issue:22

    Topics: Active Transport, Cell Nucleus; Alanine; Animals; Apoptosis; Aspartic Acid; Blotting, Northern; Blotting, Western; Cell Line; Cell Nucleus; Cytochalasin D; Cytoplasm; DNA Fragmentation; Enzyme Inhibitors; Flavonoids; Flow Cytometry; Heat-Shock Proteins; Hippocampus; Hot Temperature; HSP27 Heat-Shock Proteins; Imidazoles; Immunohistochemistry; Mitogen-Activated Protein Kinases; Models, Genetic; Mutation; Neoplasm Proteins; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Precipitin Tests; Propidium; Pyridines; Rats; Serine; Signal Transduction; Stem Cells; Temperature; Time Factors; Transfection

2002
Transcriptional regulation of the human PRL-releasing peptide (PrRP) receptor gene by a dopamine 2 Receptor agonist: cloning and characterization of the human PrRP receptor gene and its promoter region.
    Molecular endocrinology (Baltimore, Md.), 2002, Volume: 16, Issue:4

    Topics: Amino Acid Sequence; Base Sequence; Blotting, Northern; Bromocriptine; Cell Line; Cloning, Molecular; Colforsin; Cyclic AMP Response Element-Binding Protein; Dopamine Agonists; Flavonoids; Humans; Molecular Sequence Data; Nimodipine; Promoter Regions, Genetic; Receptors, Dopamine D2; Receptors, Neuropeptide; Serine; Transcription, Genetic

2002
Co-requirement of cyclic AMP- and calcium-dependent protein kinases for transcriptional activation of cholecystokinin gene by protein hydrolysates.
    The Journal of biological chemistry, 2002, Jun-21, Volume: 277, Issue:25

    Topics: Amino Acid Motifs; Benzylamines; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Cell Nucleus; Cholecystokinin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Flavonoids; Genes, Dominant; Humans; Luciferases; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Peptones; Phosphorylation; Plasmids; Promoter Regions, Genetic; Protein Binding; Protein Structure, Tertiary; Serine; Signal Transduction; Sulfonamides; Time Factors; Transcription, Genetic; Transcriptional Activation; Transfection

2002
Phosphorylation of three regulatory serines of Tob by Erk1 and Erk2 is required for Ras-mediated cell proliferation and transformation.
    Genes & development, 2002, Jun-01, Volume: 16, Issue:11

    Topics: 3T3 Cells; Alanine; Animals; Carrier Proteins; Cell Cycle; Cell Division; Cell Transformation, Neoplastic; Cyclin D1; Enzyme Inhibitors; Flavonoids; G1 Phase; Glutamic Acid; Glutamine; Glutathione Transferase; Intracellular Signaling Peptides and Proteins; Mice; Microscopy, Fluorescence; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Peptide Mapping; Phosphorylation; Phosphoserine; Plasmids; Protein Structure, Tertiary; ras Proteins; Resting Phase, Cell Cycle; S Phase; Serine; Time Factors; Transfection

2002
A functional role for nicotine in Bcl2 phosphorylation and suppression of apoptosis.
    The Journal of biological chemistry, 2003, Jan-17, Volume: 278, Issue:3

    Topics: Antineoplastic Agents; Apoptosis; Cell Survival; Drug Resistance, Neoplasm; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Mitogen-Activated Protein Kinases; Nicotine; Phosphorylation; Proto-Oncogene Proteins c-bcl-2; Serine; Staurosporine; Tumor Cells, Cultured; Type C Phospholipases

2003
Bcl-2 up-regulates ha-ras mRNA expression and induces c-Jun phosphorylation at Ser73 via an ERK-dependent pathway in PC 12 cells.
    Neuroreport, 2002, Dec-20, Volume: 13, Issue:18

    Topics: Animals; Apoptosis; Enzyme Inhibitors; Flavonoids; Gene Dosage; Gene Expression; Genes, ras; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; PC12 Cells; Phosphorylation; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-jun; Rats; RNA, Messenger; Serine; Up-Regulation

2002
Arsenite-induced phosphorylation of histone H3 at serine 10 is mediated by Akt1, extracellular signal-regulated kinase 2, and p90 ribosomal S6 kinase 2 but not mitogen- and stress-activated protein kinase 1.
    The Journal of biological chemistry, 2003, Mar-21, Volume: 278, Issue:12

    Topics: Animals; Arsenites; Cell Line; Dose-Response Relationship, Drug; Flavonoids; Histones; Mice; Mitogen-Activated Protein Kinase 1; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Ribosomal Protein S6 Kinases, 90-kDa; Serine

2003
Transcriptional activation of the NF-kappaB p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1).
    The EMBO journal, 2003, Mar-17, Volume: 22, Issue:6

    Topics: Animals; Butadienes; Cell Line; Cell Nucleus; Enzyme Inhibitors; Escherichia coli; Flavonoids; Gene Expression Regulation; Humans; Imidazoles; Isoquinolines; L Cells; Mice; Mice, Mutant Strains; Mitogen-Activated Protein Kinases; Models, Biological; Mutation; NF-kappa B; Nitriles; Phosphorylation; Protein Subunits; Pyridines; Recombinant Proteins; Ribosomal Protein S6 Kinases, 90-kDa; Serine; Sulfonamides; Transcriptional Activation; Tumor Necrosis Factor-alpha

2003
Regulation of epidermal growth factor-induced connexin 43 gap junction communication by big mitogen-activated protein kinase1/ERK5 but not ERK1/2 kinase activation.
    The Journal of biological chemistry, 2003, May-16, Volume: 278, Issue:20

    Topics: Blotting, Western; Cell Line; Connexin 43; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Flavonoids; Gap Junctions; Genes, Dominant; Humans; Immunoblotting; MAP Kinase Kinase 1; MAP Kinase Signaling System; Microscopy, Fluorescence; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase 7; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Phosphorylation; Precipitin Tests; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Serine; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Transfection

2003
Different biological effects of unmodified prolactin and a molecular mimic of phosphorylated prolactin involve different signaling pathways.
    Biochemistry, 2003, Jun-24, Volume: 42, Issue:24

    Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; DNA-Binding Proteins; Enzyme Activation; Flavonoids; Janus Kinase 2; Mammary Glands, Animal; MAP Kinase Signaling System; Mice; Milk Proteins; Mitogen-Activated Protein Kinases; Molecular Mimicry; Phosphorylation; Prolactin; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptors, Prolactin; Serine; Signal Transduction; STAT5 Transcription Factor; Trans-Activators; Tyrosine

2003
Regulation of molecular chaperone gene transcription involves the serine phosphorylation, 14-3-3 epsilon binding, and cytoplasmic sequestration of heat shock factor 1.
    Molecular and cellular biology, 2003, Volume: 23, Issue:17

    Topics: 14-3-3 Proteins; Amino Acid Sequence; Cytoplasm; DNA-Binding Proteins; Enzyme Inhibitors; Exportin 1 Protein; Fatty Acids, Unsaturated; Flavonoids; Gene Expression Regulation; Heat Shock Transcription Factors; HeLa Cells; Humans; Karyopherins; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Molecular Chaperones; Molecular Sequence Data; Phosphorylation; Protein Binding; Protein Serine-Threonine Kinases; Receptors, Cytoplasmic and Nuclear; Recombinant Proteins; Serine; Transcription Factors; Transcription, Genetic; Tyrosine 3-Monooxygenase

2003
Dual phosphorylation of phosphoinositide 3-kinase adaptor Grb2-associated binder 2 is responsible for superoxide formation synergistically stimulated by Fc gamma and formyl-methionyl-leucyl-phenylalanine receptors in differentiated THP-1 cells.
    Journal of immunology (Baltimore, Md. : 1950), 2003, Oct-15, Volume: 171, Issue:8

    Topics: Adaptor Proteins, Signal Transducing; Carrier Proteins; Cell Differentiation; Cell Line; Cross-Linking Reagents; Drug Synergism; Flavonoids; GTP-Binding Protein alpha Subunits, Gi-Go; Humans; Mitogen-Activated Protein Kinases; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphatidylinositol 3-Kinases; Phosphatidylinositol Phosphates; Phosphorylation; Protein-Tyrosine Kinases; Receptors, Formyl Peptide; Receptors, IgG; Serine; Superoxides; Threonine

2003
Suppression of adriamycin-induced apoptosis by sustained activation of the phosphatidylinositol-3'-OH kinase-Akt pathway.
    The Journal of biological chemistry, 2004, Jan-09, Volume: 279, Issue:2

    Topics: Antibiotics, Antineoplastic; Apoptosis; Biotin; Caspase 9; Caspases; Cell Line; Cell Line, Tumor; Cell Membrane; Chromones; DNA Fragmentation; Down-Regulation; Doxorubicin; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Flavonoids; Hepatocyte Growth Factor; Humans; Immunoblotting; Inositol; Morpholines; Phosphatidylinositol 3-Kinases; Phosphorylation; Precipitin Tests; Protein Binding; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-met; Recombinant Proteins; Serine; Signal Transduction; Threonine; Time Factors

2004
Phospho-serine-118 estrogen receptor-alpha detection in human breast tumors in vivo.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2004, Feb-15, Volume: 10, Issue:4

    Topics: Biomarkers, Tumor; Biopsy; Blotting, Western; Breast Neoplasms; Cell Differentiation; Cell Line, Tumor; Enzyme Inhibitors; Estrogen Receptor alpha; Flavonoids; Humans; Immunohistochemistry; Ligands; Lymphatic Metastasis; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phenotype; Phosphorylation; Phosphoserine; Prognosis; Receptors, Estrogen; Serine

2004
Erythropoietin regulation of Raf-1 and MEK: evidence for a Ras-independent mechanism.
    Blood, 2004, Jul-01, Volume: 104, Issue:1

    Topics: Animals; Cell Line; Chromones; Cytoplasm; Drug Synergism; Enzyme Inhibitors; Erythropoietin; Flavonoids; Humans; Mice; Mitogen-Activated Protein Kinase Kinases; Morpholines; Phosphorylation; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; ras Proteins; Receptors, Erythropoietin; Recombinant Proteins; Serine

2004
Thyroid hormone causes mitogen-activated protein kinase-dependent phosphorylation of the nuclear estrogen receptor.
    Endocrinology, 2004, Volume: 145, Issue:7

    Topics: Breast Neoplasms; Cell Division; Cell Line, Tumor; Cell Nucleus; Enzyme Inhibitors; Estradiol; Estrogen Receptor alpha; Flavonoids; Humans; MAP Kinase Signaling System; Phosphorylation; Receptors, Estrogen; Serine; Thyroxine

2004
Mitogen-induced rapid phosphorylation of serine 795 of the retinoblastoma gene product in vascular smooth muscle cells involves ERK activation.
    The Journal of biological chemistry, 2004, Jun-04, Volume: 279, Issue:23

    Topics: Androstadienes; Angiotensin II; Animals; Aorta; Blotting, Western; Cell Membrane; Cyclin D1; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinases; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Immunoblotting; Mitogen-Activated Protein Kinases; Mitogens; Models, Biological; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phosphorylation; Precipitin Tests; Proto-Oncogene Proteins; Rats; Retinoblastoma Protein; Serine; Serotonin; Time Factors; Wortmannin

2004
Suppression of MEK/ERK signaling pathway enhances cisplatin-induced NF-kappaB activation by protein phosphatase 4-mediated NF-kappaB p65 Thr dephosphorylation.
    The Journal of biological chemistry, 2004, Jun-18, Volume: 279, Issue:25

    Topics: Antineoplastic Agents; Cell Line; Cell Line, Tumor; Cell Nucleus; Cisplatin; Enzyme Activation; Enzyme Inhibitors; Escherichia coli; Flavonoids; Humans; Immunoblotting; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Mutagenesis, Site-Directed; NF-kappa B; Phosphoprotein Phosphatases; Phosphorylation; Plasmids; Precipitin Tests; Protein Binding; Serine; Signal Transduction; Threonine; Transcription Factor RelA; Transfection

2004
ERK1/2 contributes negative regulation to STAT3 activity in HSS-transfected HepG2 cells.
    Cell research, 2004, Volume: 14, Issue:2

    Topics: Amino Acid Substitution; Cell Division; Cell Line, Tumor; DNA-Binding Proteins; Enzyme Activation; ErbB Receptors; Flavonoids; Gene Expression Regulation; Growth Substances; Humans; Intercellular Signaling Peptides and Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogens; Peptides; Phosphorylation; Recombinant Proteins; Serine; Signal Transduction; STAT3 Transcription Factor; Trans-Activators; Transfection

2004
Novel expression of N-cadherin elicits in vitro bladder cell invasion via the Akt signaling pathway.
    Oncogene, 2004, Jun-10, Volume: 23, Issue:27

    Topics: Blotting, Western; Cadherins; Carcinoma; Cell Line, Tumor; Chromones; Clone Cells; Collagen; Drug Combinations; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Immunohistochemistry; Laminin; Morpholines; Neoplasm Invasiveness; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Proteoglycans; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-myc; Pyridines; Serine; Signal Transduction; Transfection; Urinary Bladder Neoplasms

2004
Down-regulation of WW domain-containing oxidoreductase induces Tau phosphorylation in vitro. A potential role in Alzheimer's disease.
    The Journal of biological chemistry, 2004, Jul-16, Volume: 279, Issue:29

    Topics: Alzheimer Disease; Animals; Anisomycin; Anthracenes; Brain; Cell Line; Cell Line, Tumor; COS Cells; Down-Regulation; Enzyme Inhibitors; Estradiol; Flavonoids; Genetic Vectors; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Hippocampus; Humans; Immunohistochemistry; In Vitro Techniques; Mice; Microscopy, Fluorescence; Mitogen-Activated Protein Kinases; Neurons; Oxidoreductases; Phosphorylation; Precipitin Tests; Protein Binding; Protein Structure, Tertiary; Retroviridae; RNA, Small Interfering; Serine; tau Proteins; Temperature; Threonine; Time Factors; Tumor Suppressor Proteins; Two-Hybrid System Techniques; Tyrosine; WW Domain-Containing Oxidoreductase

2004
Phosphorylation of Ser28 in histone H3 mediated by mixed lineage kinase-like mitogen-activated protein triple kinase alpha.
    The Journal of biological chemistry, 2005, Apr-08, Volume: 280, Issue:14

    Topics: Amino Acid Sequence; Animals; Cell Line; Enzyme Inhibitors; Epidermal Growth Factor; Flavonoids; Genes, Reporter; Histones; Humans; Imidazoles; MAP Kinase Kinase Kinases; MAP Kinase Signaling System; Mice; Molecular Sequence Data; Phosphorylation; Pyridines; Serine; Two-Hybrid System Techniques; Ultraviolet Rays

2005
alphaB-crystallin is phosphorylated during myocardial infarction: involvement of platelet-derived growth factor-BB.
    Archives of biochemistry and biophysics, 2005, Jun-15, Volume: 438, Issue:2

    Topics: alpha-Crystallin B Chain; Animals; Becaplermin; Blotting, Western; Disease Models, Animal; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Heart Ventricles; Imidazoles; Immunohistochemistry; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Myocardial Infarction; Myocardium; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Platelet-Derived Growth Factor; Proto-Oncogene Proteins c-sis; Pyridines; Serine; Time Factors

2005
Calmodulin-dependent protein kinases phosphorylate gp130 at the serine-based dileucine internalization motif.
    Biochimica et biophysica acta, 2005, Aug-01, Volume: 1714, Issue:1

    Topics: 3T3 Cells; Amino Acid Motifs; Amino Acid Sequence; Animals; Antibodies; Antigens, CD; Butadienes; Calcium-Calmodulin-Dependent Protein Kinase Type 1; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinase Type 4; Calcium-Calmodulin-Dependent Protein Kinases; Cytokine Receptor gp130; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Interleukin-6; Leucine; Leukemia Inhibitory Factor; MAP Kinase Signaling System; Membrane Glycoproteins; Mice; Mitogen-Activated Protein Kinase Kinases; Nitriles; Peptides; Phosphorylation; Serine

2005
Phosphorylation of extracellular signal-regulated kinase and p27(KIP1) after retinal detachment.
    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2006, Volume: 244, Issue:3

    Topics: Animals; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Cell Culture Techniques; Cell Proliferation; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p27; Disease Models, Animal; Flavonoids; Fluorescent Antibody Technique, Indirect; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neuroglia; Phosphorylation; Proliferating Cell Nuclear Antigen; Retinal Detachment; Serine

2006
Extracellular signal-regulated kinase is essential for interleukin-1-induced and nuclear factor kappaB-mediated gene expression in insulin-producing INS-1E cells.
    Diabetologia, 2005, Volume: 48, Issue:12

    Topics: Animals; Apoptosis; Blotting, Western; Cell Line, Tumor; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gene Expression; Humans; Imidazoles; Insulin; Insulin Secretion; Insulin-Secreting Cells; Interleukin-1; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase Kinases; NF-kappa B; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Rats; Serine; Synaptotagmin I

2005
Sodium tungstate decreases the phosphorylation of tau through GSK3 inactivation.
    Journal of neuroscience research, 2006, Feb-01, Volume: 83, Issue:2

    Topics: Animals; Blotting, Western; Brain; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Activation; Enzyme Inhibitors; Enzyme Reactivators; Flavonoids; Glycogen Synthase Kinase 3; Humans; Insulin; Lithium; Male; Mitogen-Activated Protein Kinase 3; Models, Molecular; Neuroblastoma; Phosphorylation; Rats; Serine; tau Proteins; Time Factors; Tungsten Compounds

2006
Serum- and glucocorticoid-inducible kinase (SGK) is a target of the MAPK/ERK signaling pathway that mediates memory formation in rats.
    The European journal of neuroscience, 2006, Volume: 23, Issue:5

    Topics: Animals; Cyclic AMP Response Element-Binding Protein; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Immediate-Early Proteins; Male; MAP Kinase Signaling System; Maze Learning; Memory; Phosphorylation; Protein Serine-Threonine Kinases; Rats; Rats, Sprague-Dawley; Recombinant Fusion Proteins; Serine

2006
ERK1/2 and p38-MAPK signalling pathways, through MSK1, are involved in NF-kappaB transactivation during oxidative stress in skeletal myoblasts.
    Cellular signalling, 2006, Volume: 18, Issue:12

    Topics: Animals; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Enzyme Activation; Flavonoids; Hydrogen Peroxide; I-kappa B Proteins; Imidazoles; Immunoblotting; Isoquinolines; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Models, Biological; Myoblasts, Skeletal; NF-kappa B; NF-KappaB Inhibitor alpha; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Ribosomal Protein S6 Kinases, 90-kDa; Serine; src-Family Kinases; Sulfonamides

2006
Regulation of endothelial nitric-oxide synthase activity through phosphorylation in response to epoxyeicosatrienoic acids.
    Prostaglandins & other lipid mediators, 2007, Volume: 82, Issue:1-4

    Topics: 8,11,14-Eicosatrienoic Acid; Amino Acid Sequence; Animals; Aorta, Thoracic; Apigenin; Cattle; Cells, Cultured; Chromones; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Epoxy Compounds; Flavonoids; Inositol; Male; MAP Kinase Signaling System; Morpholines; Nitric Oxide Synthase Type III; Oxygenases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Phosphothreonine; Proto-Oncogene Proteins c-akt; Rats; Serine

2007
Phosphorylation by extracellular signal-regulated kinase of a multidomain adaptor protein, vinexin, at synapses.
    Journal of neurochemistry, 2007, Volume: 100, Issue:2

    Topics: Actins; Adaptor Proteins, Signal Transducing; Animals; Antibodies, Monoclonal; Brain; Cells, Cultured; Chlorocebus aethiops; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Female; Flavonoids; Male; Microscopy, Immunoelectron; Mutagenesis; Neurons; Phosphorylation; Protein Structure, Tertiary; Rats; Rats, Sprague-Dawley; Serine; Synapses; Synaptophysin; Transfection

2007
Histone H3 phosphorylation at serine 10 and serine 28 is mediated by p38 MAPK in rat hepatocytes exposed to ethanol and acetaldehyde.
    European journal of pharmacology, 2007, Nov-14, Volume: 573, Issue:1-3

    Topics: Acetaldehyde; Animals; Anthracenes; Blotting, Western; Caspase 3; Cell Nucleus; Cells, Cultured; Ethanol; Flavonoids; Hepatocytes; Histones; Imidazoles; Male; Mitogen-Activated Protein Kinase Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Rats; Rats, Sprague-Dawley; Serine

2007
A Nurr1 point mutant, implicated in Parkinson's disease, uncouples ERK1/2-dependent regulation of tyrosine hydroxylase transcription.
    Neurobiology of disease, 2008, Volume: 29, Issue:1

    Topics: Cell Line, Transformed; Cysteine; DNA-Binding Proteins; Dopamine Agonists; Drug Interactions; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Humans; Mitogen-Activated Protein Kinase 3; Mutation; Neuroblastoma; Nuclear Receptor Subfamily 4, Group A, Member 2; Quinpirole; Serine; Transcription Factors; Transfection; Tyrosine 3-Monooxygenase

2008
MAPK-induced Ser727 phosphorylation promotes SUMOylation of STAT1.
    The Biochemical journal, 2008, Jan-01, Volume: 409, Issue:1

    Topics: Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Lysine; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Binding; Serine; STAT1 Transcription Factor; SUMO-1 Protein

2008
Epinephrine increases phosphorylation of MAP-2c in rat pheochromocytoma cells (PC12 Cells) via a protein kinase C- and mitogen activated protein kinase-dependent mechanism.
    Journal of proteome research, 2008, Volume: 7, Issue:4

    Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Benzophenanthridines; Clonidine; Dose-Response Relationship, Drug; Epinephrine; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Immunoblotting; Microtubule-Associated Proteins; Microtubules; Models, Biological; Neurites; Nocodazole; PC12 Cells; Phosphorylation; Protein Kinase C; Protein Kinase Inhibitors; Rats; Receptors, Adrenergic, alpha-2; Serine; Yohimbine

2008
De-phosphorylation of GR at Ser203 in nuclei associates with GR nuclear translocation and GLUT5 gene expression in Caco-2 cells.
    Archives of biochemistry and biophysics, 2008, Jul-01, Volume: 475, Issue:1

    Topics: Caco-2 Cells; Cell Nucleus; Dexamethasone; Dose-Response Relationship, Drug; Flavonoids; Gene Expression Regulation; Glucose Transporter Type 5; Humans; Phosphorylation; Receptors, Glucocorticoid; Serine

2008
Phosphorylation of Argonaute 2 at serine-387 facilitates its localization to processing bodies.
    The Biochemical journal, 2008, Aug-01, Volume: 413, Issue:3

    Topics: Amino Acid Sequence; Anthracenes; Argonaute Proteins; Arsenites; Blotting, Western; Cell Line; Eukaryotic Initiation Factor-2; Flavonoids; Glutathione Transferase; Humans; Imidazoles; Immunoprecipitation; Intracellular Signaling Peptides and Proteins; JNK Mitogen-Activated Protein Kinases; Mass Spectrometry; Microscopy, Confocal; Mitogen-Activated Protein Kinase Kinases; Molecular Sequence Data; Mutation; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Pyridines; Recombinant Proteins; Sequence Homology, Amino Acid; Serine; Sodium Compounds

2008
Phosphorylation of histone H3 by protein kinase C signaling plays a critical role in the regulation of the developmentally important TBX2 gene.
    The Journal of biological chemistry, 2009, Sep-25, Volume: 284, Issue:39

    Topics: Binding Sites; Blotting, Western; Cell Line; Chromatin Immunoprecipitation; Enzyme Inhibitors; Fibroblasts; Flavonoids; Gene Expression; Histones; Humans; Imidazoles; Indoles; Maleimides; Mitogen-Activated Protein Kinases; Phosphorylation; Promoter Regions, Genetic; Protein Binding; Protein Kinase C; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; Ribosomal Protein S6 Kinases, 90-kDa; RNA Interference; Serine; Signal Transduction; Sp1 Transcription Factor; T-Box Domain Proteins; Tetradecanoylphorbol Acetate

2009
Calnexin phosphorylation attenuates the release of partially misfolded alpha1-antitrypsin to the secretory pathway.
    The Journal of biological chemistry, 2009, Dec-11, Volume: 284, Issue:50

    Topics: Alkaloids; alpha 1-Antitrypsin; Animals; Calnexin; Cell Line, Tumor; Enzyme Inhibitors; Flavonoids; Humans; Mitogen-Activated Protein Kinase 3; Phosphorylation; Protein Folding; Secretory Pathway; Serine

2009
Phosphorylation of serine282 in NADPH oxidase activator 1 by Erk desensitizes EGF-induced ROS generation.
    Biochemical and biophysical research communications, 2010, Apr-09, Volume: 394, Issue:3

    Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Amino Acid Sequence; Cell Line; Epidermal Growth Factor; Extracellular Signal-Regulated MAP Kinases; Feedback, Physiological; Flavonoids; Humans; Molecular Sequence Data; Phosphorylation; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Serine

2010
Melatonin triggers p53Ser phosphorylation and prevents DNA damage accumulation.
    Oncogene, 2012, Jun-14, Volume: 31, Issue:24

    Topics: Animals; Antioxidants; Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins; Cell Line; Cell Proliferation; DNA Damage; DNA-Binding Proteins; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Melatonin; Mice; Nuclear Proteins; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Promyelocytic Leukemia Protein; Protein Serine-Threonine Kinases; Pyridines; Serine; Transcription Factors; Tumor Suppressor Protein p53; Tumor Suppressor Proteins

2012
Extracellular signal-regulated kinase 2 (ERK2) mediates phosphorylation and inactivation of nuclear interaction partner of anaplastic lymphoma kinase (NIPA) at G2/M.
    The Journal of biological chemistry, 2012, Nov-02, Volume: 287, Issue:45

    Topics: Adaptor Proteins, Signal Transducing; Animals; Butadienes; Cell Cycle Proteins; Cell Division; Cells, Cultured; Enzyme Inhibitors; Flavonoids; G2 Phase; HEK293 Cells; Humans; Immunoblotting; Mice; Mice, Knockout; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mutation; NIH 3T3 Cells; Nitriles; Nuclear Proteins; Phosphorylation; Protein Binding; RNA Interference; Serine

2012
Novel involvement of leukotriene B₄ receptor 2 through ERK activation by PP2A down-regulation in leukotriene B₄-induced keratin phosphorylation and reorganization of pancreatic cancer cells.
    Biochimica et biophysica acta, 2012, Volume: 1823, Issue:12

    Topics: Anesthetics, Inhalation; Blotting, Western; Cell Adhesion; Cell Movement; Cell Proliferation; Down-Regulation; Enzyme Activation; Ethers; Flavonoids; Flow Cytometry; Fluorescent Antibody Technique; Humans; Hydrocarbons, Fluorinated; Immunoprecipitation; Keratin-8; Leukotriene B4; Mitogen-Activated Protein Kinase 3; Pancreatic Neoplasms; Phosphorylation; Protein Phosphatase 2; Receptors, Leukotriene B4; RNA, Messenger; RNA, Small Interfering; Serine; Signal Transduction; Tumor Cells, Cultured

2012
Serine 111 phosphorylation regulates OCT4A protein subcellular distribution and degradation.
    The Journal of biological chemistry, 2012, Nov-02, Volume: 287, Issue:45

    Topics: Cell Line, Tumor; Fibroblast Growth Factor 2; Flavonoids; Gene Expression; Homeodomain Proteins; Humans; Immunoblotting; Immunoprecipitation; Kruppel-Like Transcription Factors; Leupeptins; MAP Kinase Kinase 1; Microscopy, Fluorescence; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nanog Homeobox Protein; Octamer Transcription Factor-3; Phosphorylation; Protein Binding; Protein Isoforms; Proteolysis; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Serine; SOXB1 Transcription Factors; Ubiquitination

2012
Significant correlation between the acceleration of platelet aggregation and phosphorylation of HSP27 at Ser-78 in diabetic patients.
    International journal of molecular medicine, 2012, Volume: 30, Issue:6

    Topics: Adenosine Diphosphate; Aged; Blood Platelets; Case-Control Studies; CD40 Ligand; Diabetes Mellitus, Type 2; Female; Flavonoids; Heat-Shock Proteins; HSP27 Heat-Shock Proteins; Humans; Imidazoles; Male; Middle Aged; Mitogen-Activated Protein Kinase Kinases; Molecular Chaperones; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Platelet Aggregation; Protein Processing, Post-Translational; Pyridines; Serine

2012
FBXL5 targets cortactin for ubiquitination-mediated destruction to regulate gastric cancer cell migration.
    Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2014, Volume: 35, Issue:9

    Topics: Binding Sites; Blotting, Western; Cell Line, Tumor; Cell Movement; Cortactin; Extracellular Signal-Regulated MAP Kinases; F-Box Proteins; Flavonoids; Humans; Mutation; Phosphorylation; Proteasome Endopeptidase Complex; Protein Binding; Protein Kinase Inhibitors; Proteolysis; RNA Interference; Serine; Stomach Neoplasms; Ubiquitin-Protein Ligase Complexes; Ubiquitin-Protein Ligases; Ubiquitination

2014
Oxidative Stress Induces Neuronal Apoptosis Through Suppressing Transcription Factor EB Phosphorylation at Ser467.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2018, Volume: 46, Issue:4

    Topics: Androstadienes; Animals; Apoptosis; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Cell Line, Tumor; Flavonoids; HEK293 Cells; Humans; Hydrogen Peroxide; Male; Mice, Inbred C57BL; Neurons; Oxidative Stress; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Serine; Signal Transduction; Wortmannin

2018