Page last updated: 2024-08-24

sch 37370 and loratadine

sch 37370 has been researched along with loratadine in 11 studies

Research

Studies (11)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	9 (81.82)	18.2507
2000's	1 (9.09)	29.6817
2010's	1 (9.09)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Billah, MM; Ganguly, AK; Green, MJ; Kreutner, W; Piwinski, JJ; West, RE; Wong, JK	1
Almansa, C; Balsa, D; Bartrolí, J; Carceller, E; Forn, J; García-Rafanell, J; Giral, M; Merlos, M	1
Albanese, MM; Anthes, JC; Billah, MM; Colizzo, F; Ganguly, AK; Green, MJ; Kaminski, JJ; Piwinski, JJ; West, RE; Wong, JK	1
Morphy, R; Rankovic, Z	1
Buschauer, A; Cuboni, S; Devigny, C; Eder, M; Hauger, B; Hausch, F; Höfner, G; Holsboer, F; Hoogeland, B; Pomplun, S; Strasser, A; Wanner, KT	1
Affrime, MB; Billah, MM; Brannan, MD; Christopher, JD; Eckel, SP; Gilchrest, HG; Granzow, CA; Lawton, PJ; Radwanski, E; Richards, W	1
Billah, MM; Chapman, RW; Egan, RW; Kreutner, W; Siegel, MI; Watnick, AS	1
Billah, MM; Egan, RW; Ganguly, AK; Green, MJ; Kreutner, W; Piwinski, JJ; Siegel, MI; Villani, FJ; Wong, JK	1
Billah, MM; Chapman, RW; Egan, RW; Gilchrest, H; Kreutner, W; Piwinski, JJ; Sherwood, J; Siegel, MI; West, RE	1
Centemeri, C; Ciceri, P; Colli, S; Nicosia, S; Tosarello, D	1
Billah, MM; Carruthers, NI; Chan, TM; Kaminski, JJ; McPhail, AT; Tozzi, S; Wong, SC	1

Reviews

1 review(s) available for sch 37370 and loratadine

Article	Year
Designed multiple ligands. An emerging drug discovery paradigm. Journal of medicinal chemistry, 2005, Oct-20, Volume: 48, Issue:21 Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Anti-Allergic Agents; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents; Antihypertensive Agents; Antipsychotic Agents; Chemistry, Pharmaceutical; Dopamine D2 Receptor Antagonists; Drug Design; Humans; Ligands; Metabolic Diseases; Peroxisome Proliferator-Activated Receptors; Receptors, Histamine H1; Selective Serotonin Reuptake Inhibitors	2005

Article

Year

Designed multiple ligands. An emerging drug discovery paradigm.

Journal of medicinal chemistry, 2005, Oct-20, Volume: 48, Issue:21

Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Anti-Allergic Agents; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents; Antihypertensive Agents; Antipsychotic Agents; Chemistry, Pharmaceutical; Dopamine D2 Receptor Antagonists; Drug Design; Humans; Ligands; Metabolic Diseases; Peroxisome Proliferator-Activated Receptors; Receptors, Histamine H1; Selective Serotonin Reuptake Inhibitors

2005

Trials

1 trial(s) available for sch 37370 and loratadine

Article	Year
Differential plasma duration of antiplatelet-activating factor and antihistamine activities of oral Sch 37370 in humans. Clinical pharmacology and therapeutics, 1992, Volume: 52, Issue:2 Topics: Administration, Oral; Adult; Double-Blind Method; Electrocardiography; Histamine Antagonists; Humans; Loratadine; Male; Piperidines; Platelet Activating Factor	1992

Other Studies

9 other study(ies) available for sch 37370 and loratadine

Article	Year
Dual antagonists of platelet activating factor and histamine. Identification of structural requirements for dual activity of N-Acyl-4-(5,6-dihydro-11H-benzo [5,6]cyclohepta-[1,2-b]pyridin-11-ylidene)piperidines. Journal of medicinal chemistry, 1991, Volume: 34, Issue:1 Topics: Animals; Guinea Pigs; Histamine H1 Antagonists; Indicators and Reagents; Lung; Molecular Structure; Piperidines; Platelet Activating Factor; Receptors, Histamine H1; Structure-Activity Relationship	1991
[(3-Pyridylalkyl)piperidylidene]benzocycloheptapyridine derivatives as dual antagonists of PAF and histamine. Journal of medicinal chemistry, 1994, Aug-19, Volume: 37, Issue:17 Topics: Anaphylaxis; Animals; Benzocycloheptenes; Blood Pressure; Guinea Pigs; Histamine; Histamine H1 Antagonists; Ileum; In Vitro Techniques; Indicators and Reagents; Magnetic Resonance Spectroscopy; Male; Mice; Molecular Structure; Muscle Contraction; Muscle, Smooth; Piperidines; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rabbits; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship	1994
Dual antagonists of platelet activating factor and histamine. 3. Synthesis, biological activity and conformational implications of substituted N-acyl-bis-arylcycloheptapiperazines. Bioorganic & medicinal chemistry letters, 1998, Dec-15, Volume: 8, Issue:24 Topics: Histamine Antagonists; Molecular Conformation; Piperazines; Platelet Activating Factor; Stereoisomerism	1998
Loratadine and analogues: discovery and preliminary structure-activity relationship of inhibitors of the amino acid transporter B(0)AT2. Journal of medicinal chemistry, 2014, Nov-26, Volume: 57, Issue:22 Topics: Amino Acid Transport Systems, Neutral; Binding, Competitive; Brain; Cell Membrane; Chemistry, Pharmaceutical; Electrophysiology; Green Fluorescent Proteins; HEK293 Cells; Histamine H1 Antagonists, Non-Sedating; Humans; Inhibitory Concentration 50; Kinetics; Loratadine; Nerve Tissue Proteins; Patch-Clamp Techniques; Receptors, Histamine H1; Structure-Activity Relationship	2014
Sch 37370: a new drug combining antagonism of platelet-activating factor (PAF) with antagonism of histamine. Agents and actions. Supplements, 1991, Volume: 34 Topics: Animals; Antigens; Bronchial Spasm; Guinea Pigs; Histamine Antagonists; Humans; Hyperventilation; Loratadine; Male; Piperidines; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Rats, Inbred Lew	1991
Discovery and preliminary pharmacology of Sch 37370, a dual antagonist of PAF and histamine. Lipids, 1991, Volume: 26, Issue:12 Topics: Histamine Antagonists; Humans; Kinetics; Loratadine; Male; Piperidines; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Structure-Activity Relationship	1991
Sch 37370: a potent, orally active, dual antagonist of platelet-activating factor and histamine. The Journal of pharmacology and experimental therapeutics, 1990, Volume: 252, Issue:3 Topics: Administration, Oral; Animals; Binding, Competitive; Brain; Bronchial Spasm; Female; Guinea Pigs; Histamine; Histamine Antagonists; Humans; Loratadine; Lung; Macaca fascicularis; Male; Mice; Piperidines; Platelet Activating Factor; Platelet Aggregation; Pyrilamine; Rats	1990
Heterogeneous platelet-activating factor (PAF) receptors and calcium increase in platelets and macrophages. Biochemical pharmacology, 1999, Feb-01, Volume: 57, Issue:3 Topics: Animals; Azepines; Blood Platelets; Calcium; Cytosol; Humans; Loratadine; Macrophages; Male; Piperidines; Platelet Membrane Glycoproteins; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles	1999
Conformational considerations in the design of dual antagonists of platelet-activating factor (PAF) and histamine. Bioorganic & medicinal chemistry, 1999, Volume: 7, Issue:7 Topics: Animals; Anti-Allergic Agents; Crystallography, X-Ray; Drug Design; Drug Evaluation, Preclinical; Guinea Pigs; Histamine Antagonists; Humans; Inhibitory Concentration 50; Isoquinolines; Loratadine; Mice; Models, Molecular; Molecular Conformation; Molecular Mimicry; Piperazines; Piperidines; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Pyridines; Rats; Receptors, Histamine H1; Stereoisomerism; Structure-Activity Relationship	1999