sb 202190 and pd 98059

Topics: Androstadienes; Animals; Chromones; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Indoles; Maleimides; Morpholines; Protein Kinase Inhibitors; Pyridines; Signal Transduction; Sirolimus; Wortmannin

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Alkaloids; Amides; Animals; Benzamides; Benzophenanthridines; Benzopyrans; Butadienes; Cell Line; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Indoles; Inhibitory Concentration 50; Isoquinolines; Lithium; Magnesium; Nitriles; Phenanthridines; Phosphorylation; Potassium Chloride; Protein Kinase Inhibitors; Protein Kinases; Pyridines; Sirolimus; Substrate Specificity; Sulfonamides

Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells

Topics: Amino Acid Sequence; Binding Sites; Clinical Trials as Topic; Drug Evaluation, Preclinical; Enzyme Stability; Humans; Molecular Sequence Data; Phylogeny; Protein Array Analysis; Protein Conformation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases

Topics: Animals; Antimalarials; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chromosome Mapping; Crosses, Genetic; Dihydroergotamine; Drug Design; Drug Resistance; Humans; Inhibitory Concentration 50; Mutation; Plasmodium falciparum; Quantitative Trait Loci; Transfection

Topics: Animals; Cells, Cultured; Coumarins; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flowers; Mammea; Mice; Molecular Structure; Nitric Oxide Synthase Type II; Stereoisomerism; Structure-Activity Relationship

Topics: Aurora Kinases; Cluster Analysis; Drug Design; Drug Discovery; Drug Evaluation, Preclinical; ErbB Receptors; Humans; Intracellular Signaling Peptides and Proteins; MAP Kinase Kinase 4; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Receptors, Vascular Endothelial Growth Factor; Recombinant Proteins; Reproducibility of Results; Signal Transduction; Small Molecule Libraries; Structure-Activity Relationship; Syk Kinase

Topics: Amino Acid Sequence; Animals; Base Sequence; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Cloning, Molecular; DNA, Complementary; Enzyme Activation; Enzyme Inhibitors; Flavonoids; HeLa Cells; Humans; Imidazoles; Intracellular Signaling Peptides and Proteins; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Molecular Sequence Data; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Pyridines; Recombinant Fusion Proteins; Sequence Homology, Amino Acid; Signal Transduction; Spodoptera; Substrate Specificity

Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Inhibitors; Farnesyl-Diphosphate Farnesyltransferase; Flavonoids; Gene Expression Regulation; Humans; Imidazoles; Interleukin-1; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Pyridines; Receptors, LDL; Signal Transduction; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha

Topics: Activating Transcription Factor 2; Adjuvants, Immunologic; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Chloroquine; CpG Islands; Cyclic AMP Response Element-Binding Protein; Cytokines; DNA; DNA Methylation; DNA-Binding Proteins; Enzyme Activation; Enzyme Induction; Enzyme Inhibitors; Flavonoids; Homeodomain Proteins; Imidazoles; JNK Mitogen-Activated Protein Kinases; Lymphoma, B-Cell; MAP Kinase Kinase 2; Mice; Minor Histocompatibility Antigens; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Oligonucleotides; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-bcl-2; Pyridines; Replication Protein C; Repressor Proteins; Saccharomyces cerevisiae Proteins; Signal Transduction; Transcription Factors; Tumor Cells, Cultured

Topics: 3T3 Cells; Adipocytes; Amino Acid Sequence; Animals; Binding Sites; Calcium-Calmodulin-Dependent Protein Kinases; CCAAT-Enhancer-Binding Proteins; Cell Differentiation; DNA-Binding Proteins; Enzyme Induction; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Imidazoles; Mice; Mitogen-Activated Protein Kinases; Nuclear Proteins; p38 Mitogen-Activated Protein Kinases; Pyridines; Sequence Alignment; Transcription Factors

Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Adult; Androstadienes; Anticarcinogenic Agents; Apoptosis; Bronchoalveolar Lavage Fluid; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; Cells, Cultured; Culture Media, Serum-Free; Enzyme Inhibitors; Epithelial Cells; Flavonoids; Humans; Imidazoles; Inositol; L-Lactate Dehydrogenase; Lung; MAP Kinase Kinase 1; Melitten; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Biosynthesis; Protein Kinase C; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Pyridines; Signal Transduction; Uteroglobin; Wortmannin

Topics: Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Dose-Response Relationship, Drug; Flavonoids; Humans; Imidazoles; Interferon-gamma; Lipopolysaccharides; Macrophages; Mitogen-Activated Protein Kinases; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Pyridines; Tumor Necrosis Factor-alpha

Topics: Antibodies, Monoclonal; Base Sequence; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; DNA Primers; Enzyme Inhibitors; Flavonoids; Imidazoles; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Precipitin Tests; Pyridines; Serine; Transcription, Genetic; Tumor Suppressor Protein p53; Ultraviolet Rays

Topics: Acetophenones; Animals; Apoptosis; Benzopyrans; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Cell Membrane; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Imidazoles; Indoles; Isoenzymes; Maleimides; Mice; Mutation; Protein Kinase C; Protein Kinase C-alpha; Protein Kinase C-delta; Protein Kinase C-epsilon; Pyridines; Signal Transduction; Sphingosine; Ultraviolet Rays

Topics: Calcium-Calmodulin-Dependent Protein Kinases; Cholesterol; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Humans; Imidazoles; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Promoter Regions, Genetic; Pyridines; Receptors, LDL; Signal Transduction; Tumor Cells, Cultured

Topics: Apoptosis; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Cell Survival; Cyclooxygenase Inhibitors; Cytokines; Cytosol; DNA Fragmentation; Enzyme Inhibitors; Eosinophils; Flavonoids; Humans; Imidazoles; In Vitro Techniques; Interleukin-5; Lipoxygenase Inhibitors; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Pyridines

Topics: Androstadienes; Blood Proteins; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Chondrocytes; Collagen; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Flavonoids; Humans; Imidazoles; Isoquinolines; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Mutation; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Promoter Regions, Genetic; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-raf; Pyridines; Signal Transduction; Sulfonamides; Transcriptional Activation; Transfection; Wortmannin

Topics: Antioxidants; Apoptosis; Calcium-Calmodulin-Dependent Protein Kinases; Caspase 3; Caspase Inhibitors; Caspases; DNA Fragmentation; Dopamine; Enzyme Activation; Flavonoids; Humans; Imidazoles; Mitogen-Activated Protein Kinases; Molsidomine; Neuroblastoma; Neurodegenerative Diseases; Neurons; Nitrates; Nitric Oxide; p38 Mitogen-Activated Protein Kinases; Pyridines; Signal Transduction; Superoxides; Tumor Cells, Cultured

Topics: Androstadienes; Antibodies, Monoclonal; Benzoquinones; Cell Adhesion; Enzyme Activation; Enzyme Inhibitors; Fibronectins; Flavonoids; Gene Expression Regulation; Gene Expression Regulation, Neoplastic; Genes, ras; GTP-Binding Proteins; Humans; Imidazoles; Integrins; Jurkat Cells; Lactams, Macrocyclic; MAP Kinase Signaling System; Matrix Metalloproteinase 2; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Matrix Metalloproteinases, Membrane-Associated; Metalloendopeptidases; Neoplasm Proteins; Peptide Fragments; Pertussis Toxin; Phosphoinositide-3 Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins p21(ras); Pyridines; Quinones; Rifabutin; src-Family Kinases; T-Lymphocytes; Tissue Inhibitor of Metalloproteinase-1; Tissue Inhibitor of Metalloproteinase-2; Transfection; Tumor Cells, Cultured; Virulence Factors, Bordetella; Wortmannin

Topics: Astrocytoma; Cell Nucleus; DNA-Binding Proteins; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Humans; Imidazoles; Interferon Regulatory Factor-3; Interferon-alpha; Lipopolysaccharides; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Pyridines; Transcription Factors; Tumor Cells, Cultured

Topics: Cell Line; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Genes, fos; Humans; Imidazoles; Intracellular Signaling Peptides and Proteins; Keratinocytes; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Protein Biosynthesis; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-fos; Pyridines; Transcription, Genetic; Ultraviolet Rays

Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acids; Cells, Cultured; Cyclic GMP; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dipyridamole; Enzyme Inhibitors; Flavonoids; Guanylate Cyclase; Imidazoles; Indazoles; Isoenzymes; Lipopolysaccharides; MAP Kinase Kinase 1; MAP Kinase Kinase 2; MAP Kinase Signaling System; Mice; Microglia; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; p38 Mitogen-Activated Protein Kinases; Phospholipases A; Phospholipases A2; Phosphorylcholine; Prostaglandin-Endoperoxide Synthases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Pyridines; Signal Transduction; Tumor Necrosis Factor-alpha

Topics: Calcium-Calmodulin-Dependent Protein Kinases; Cell Degranulation; Chemokine CCL11; Chemokines, CC; Chemotactic Factors, Eosinophil; Chemotaxis; Cytokines; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Eosinophilia; Eosinophils; Flavonoids; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Kinetics; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Precipitin Tests; Pyridines; Signal Transduction; Time Factors

Topics: Animals; Cell Line; Enzyme Inhibitors; Flavonoids; Imidazoles; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Mutation; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Serine; Tumor Suppressor Protein p53; Ultraviolet Rays

Topics: Animals; Cell Line; Enzyme Inhibitors; Flavonoids; Histones; Imidazoles; Kinetics; MAP Kinase Kinase 1; Mice; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinase 9; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Phosphoserine; Protein Serine-Threonine Kinases; Pyridines; Serine; Ultraviolet Rays

Topics: Animals; Cell Differentiation; Chelating Agents; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; DNA-Binding Proteins; Dose-Response Relationship, Drug; Egtazic Acid; Enzyme Inhibitors; Epidermal Growth Factor; Flavonoids; Gene Expression; Genes, Reporter; GTP-Binding Proteins; Humans; Imidazoles; Indoles; Luciferases; Maleimides; Mitogen-Activated Protein Kinases; Nerve Growth Factors; Neurons; NF-kappa B; NFATC Transcription Factors; Norepinephrine; Nuclear Proteins; p38 Mitogen-Activated Protein Kinases; PC12 Cells; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Pyridines; Rats; Receptors, Adrenergic, alpha-1; Sympathomimetics; Transcription Factors; Transcriptional Activation; Transfection

Topics: Adenocarcinoma; Amitrole; Catalase; Cell Division; Chelating Agents; Chromates; Drug Interactions; Enzyme Activation; Enzyme Activators; Enzyme Inhibitors; Flavonoids; Fluoresceins; Fluorescent Dyes; Free Radical Scavengers; Humans; Hydrogen Peroxide; Imidazoles; JNK Mitogen-Activated Protein Kinases; Lung Neoplasms; Mannitol; MAP Kinase Kinase 4; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Potassium Compounds; Pyridines; Tumor Cells, Cultured

Topics: Adrenergic alpha-Agonists; Androstadienes; Cell Cycle; Chemotaxis; Chromones; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; Morpholines; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Pyridines; Receptors, Adrenergic, alpha-1; Recombinant Proteins; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Transfection; Tumor Cells, Cultured; Wortmannin

Topics: Apoptosis; Cell Hypoxia; Chromones; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Humans; Imidazoles; Kinetics; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Morpholines; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Proteins; Neutrophils; p38 Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins c-bcl-2; Pyridines

Topics: Cell Survival; Cells, Cultured; Cyclooxygenase 2; Endothelium, Vascular; Enzyme Inhibitors; Epoprostenol; Escherichia coli; Flavonoids; Humans; Imidazoles; Isoenzymes; Kinetics; Lipopolysaccharides; Membrane Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Prostaglandin-Endoperoxide Synthases; Pyridines; Saline Solution, Hypertonic; Umbilical Veins

Topics: Animals; Cell Degranulation; Cell Differentiation; Cell Survival; Chemokine CCL3; Chemokine CCL4; Enzyme Activation; Enzyme Inhibitors; Eosinophils; Flavonoids; Humans; Imidazoles; Interleukin-5; Macrophage Inflammatory Proteins; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines

Topics: Androstadienes; Animals; Caffeine; Cisplatin; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; DNA Damage; Dose-Response Relationship, Drug; Enzyme Activation; Flavonoids; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Half-Life; Humans; Imidazoles; Mice; Mitogen-Activated Protein Kinases; Nuclear Proteins; Phosphorylation; Phosphoserine; Precipitin Tests; Protein Binding; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-mdm2; Pyridines; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Wortmannin

Topics: Blotting, Northern; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Insulin-Like Growth Factor Binding Protein 1; Interleukin-1; Isoquinolines; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Radioimmunoassay; RNA, Messenger; Signal Transduction; Stimulation, Chemical; Sulfonamides; Tumor Cells, Cultured

Topics: Animals; Antioxidants; Aspirin; Cell Line; Chromates; Enzyme Activation; Enzyme Inhibitors; Fibroblasts; Flavonoids; I-kappa B Kinase; Imidazoles; Macrophages; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinases; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Protein Serine-Threonine Kinases; Pyridines; Reactive Oxygen Species; Transcription Factor AP-1; Transfection

Topics: Animals; Antimutagenic Agents; Antioxidants; Apoptosis; Arsenites; Biflavonoids; Catechin; Cells, Cultured; DNA; Drug Interactions; Flavonoids; Imidazoles; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phenols; Phosphorylation; Polymers; Pyridines; Skin; Tea; Teratogens; Transcription Factor AP-1

Topics: Analysis of Variance; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Aorta; Benzimidazoles; Biphenyl Compounds; Collagen; Decorin; Enzyme Activation; Enzyme Inhibitors; Extracellular Matrix Proteins; Flavonoids; Gene Expression Regulation, Enzymologic; Genes, fos; Genetic Markers; Humans; Imidazoles; Kidney; Luciferases; Male; Mice; Mice, Transgenic; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Proteoglycans; Proto-Oncogene Mas; Pyridines; Tetrazoles; Transcriptional Activation; Transforming Growth Factor beta

Topics: CD55 Antigens; Cells, Cultured; Complement Activation; Complement System Proteins; Endothelial Growth Factors; Endothelium, Vascular; Enzyme Inhibitors; Feedback; Flavonoids; Gene Expression Regulation; Humans; Imidazoles; Indoles; Inflammation; Lymphokines; Maleimides; MAP Kinase Kinase 1; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; NF-kappa B; Oligopeptides; p38 Mitogen-Activated Protein Kinases; Peptide Fragments; Protein Kinase C; Protein Serine-Threonine Kinases; Pyridines; Receptor, PAR-1; Receptors, Thrombin; Recombinant Proteins; RNA, Messenger; Thrombin; Thrombosis; Umbilical Veins; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors

Topics: Cell Line; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Enzymologic; Glutamate-Cysteine Ligase; Humans; Imidazoles; Mitogen-Activated Protein Kinases; NF-E2-Related Factor 2; p38 Mitogen-Activated Protein Kinases; Protein Binding; Pyridines; Pyrrolidines; Thiocarbamates; Trans-Activators; Transcription, Genetic; Transcriptional Activation

Topics: Caco-2 Cells; Cell Division; Cell Movement; Cytoskeletal Proteins; Enzyme Inhibitors; Extracellular Matrix; Flavonoids; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Gene Expression Regulation, Enzymologic; Humans; Imidazoles; Integrins; Intestines; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinase 9; Mitogen-Activated Protein Kinases; Naphthalenes; p38 Mitogen-Activated Protein Kinases; Paxillin; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Pyridines; Stress, Mechanical; Transfection

Topics: Animals; Blotting, Western; Carrier Proteins; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Humans; Imidazoles; Lectins; Macrophages; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Naphthalenes; p38 Mitogen-Activated Protein Kinases; Protein Kinase C; Pyridines; Rats; Receptors, Cell Surface; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; U937 Cells

Topics: Androstadienes; Animals; Base Sequence; Blotting, Western; Cells, Cultured; DNA Primers; DNA Replication; DNA-Binding Proteins; Early Growth Response Protein 1; Endothelium, Vascular; Fibroblast Growth Factor 2; Flavonoids; Glucose; Humans; Imidazoles; Immediate-Early Proteins; Insulin; Oligonucleotides, Antisense; Pyridines; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transcription Factors; Wortmannin

Topics: Cell Adhesion; Chemokine CX3CL1; Chemokines, CX3C; Chemokines, CXC; Cholera Toxin; Chromones; CX3C Chemokine Receptor 1; Enzyme Inhibitors; Enzyme Precursors; Fibronectins; Flavonoids; GTP-Binding Proteins; Humans; Imidazoles; Intracellular Signaling Peptides and Proteins; Membrane Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinases; Monocytes; Morpholines; p38 Mitogen-Activated Protein Kinases; Pertussis Toxin; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); Pyridines; Receptors, Cytokine; Receptors, HIV; Signal Transduction; Syk Kinase; Virulence Factors, Bordetella

Topics: Animals; Apoptosis; Cell Line, Transformed; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Mice; Mice, Knockout; Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Sphingomyelin Phosphodiesterase; Ultraviolet Rays

Topics: Arabidopsis Proteins; Base Sequence; Binding Sites; Cell Line; DNA-Binding Proteins; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Epstein-Barr Virus Nuclear Antigens; Erythroid-Specific DNA-Binding Factors; Flavonoids; Flow Cytometry; Gene Expression Regulation, Enzymologic; Genes, Reporter; Humans; Imidazoles; Interleukin-10; Lipopolysaccharide Receptors; Lipopolysaccharides; Luciferases; Macrophages; Mitogen-Activated Protein Kinases; Molecular Sequence Data; p38 Mitogen-Activated Protein Kinases; Plant Proteins; Plasmids; Polymerase Chain Reaction; Promoter Regions, Genetic; Pyridines; Signal Transduction; Sp1 Transcription Factor; Time Factors; Transcription Factors; Transcription, Genetic; Transfection; Viral Proteins; YY1 Transcription Factor

Topics: Animals; Animals, Newborn; Cells, Cultured; Enzyme Inhibitors; Flavonoids; Heart; Heart Ventricles; Hydrogen-Ion Concentration; Imidazoles; In Vitro Techniques; Kinetics; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Myocardial Ischemia; Myocardial Reperfusion; Myocardium; Protein Kinases; Pyridines; Rats; Rats, Sprague-Dawley; Recombinant Fusion Proteins; Ribosomal Protein S6 Kinases; Sodium-Hydrogen Exchangers

Topics: Androstadienes; Animals; Cell Line; Enzyme Activation; Enzyme Inhibitors; Fibroblasts; Flavonoids; Imidazoles; MAP Kinase Signaling System; Mice; Mice, Knockout; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinase 9; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Subunits; Pyridines; Ribosomal Protein S6 Kinases; Sirolimus; Transfection; Ultraviolet Rays; Wortmannin

Topics: Animals; Antigen-Antibody Complex; Apoptosis; Autoradiography; Cell Division; Cell Line; Cells, Cultured; DNA; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Enzyme Inhibitors; Epithelial Cells; Flavonoids; Flow Cytometry; Humans; Image Processing, Computer-Assisted; Imidazoles; JNK Mitogen-Activated Protein Kinases; Kinetics; Lung; Male; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Precipitin Tests; Pyridines; Rats; Rats, Inbred Strains; Sensitivity and Specificity; Sodium Fluoride; Species Specificity

Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Antibodies; Cell Line; Drug Synergism; Enzyme Inhibitors; Flavonoids; Genistein; Humans; Imidazoles; Interferon-gamma; Kinetics; Matrix Metalloproteinase 9; Monocytes; Peptide Fragments; Pyridines; RNA, Messenger; Tumor Necrosis Factor-alpha

Topics: Carcinoma; Colonic Neoplasms; Cyclooxygenase 2; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Isoenzymes; Lipopolysaccharides; Membrane Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Osmotic Pressure; p38 Mitogen-Activated Protein Kinases; Prostaglandin-Endoperoxide Synthases; Pyridines; Saline Solution, Hypertonic; Signal Transduction; Tumor Cells, Cultured

Topics: Angiotensin II; Animals; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Hypertension; Imidazoles; JNK Mitogen-Activated Protein Kinases; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; p38 Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins c-fos; Pyridines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Reference Values; RNA, Messenger; Vasoconstrictor Agents

Topics: Animals; Cattle; Cell Nucleus; Cells, Cultured; DNA-Binding Proteins; Endothelium, Vascular; Enzyme Inhibitors; Flavonoids; Imidazoles; Kinetics; Lysophosphatidylcholines; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase Kinases; Platelet-Derived Growth Factor; Promoter Regions, Genetic; Protein Serine-Threonine Kinases; Pyridines; RNA, Messenger; Transcription Factors; Transcriptional Activation

Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Chromones; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Imidazoles; Insulin; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinases; Morpholines; Mutation; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyridines; Ribosomal Protein S6 Kinases, 90-kDa; Ultraviolet Rays

Topics: Animals; Calcium; Enzyme Inhibitors; Flavonoids; Genes, Reporter; Humans; Imidazoles; Inositol Phosphates; Mitogen-Activated Protein Kinase Kinases; Norepinephrine; PC12 Cells; Protein Kinase C; Protein-Tyrosine Kinases; Pyridines; Rats; Receptors, Adrenergic, alpha-1; Signal Transduction; Time Factors; Transcription, Genetic; Transfection

Topics: Anilides; Blotting, Western; Cell Nucleus; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Fluorescent Antibody Technique, Indirect; Gammaretrovirus; Humans; Imidazoles; Interleukin-6; Male; Microscopy, Fluorescence; Mitogen-Activated Protein Kinases; Nitriles; Plasmids; Promoter Regions, Genetic; Prostate-Specific Antigen; Prostatic Neoplasms; Pyridines; Receptors, Androgen; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tosyl Compounds; Transcriptional Activation; Transfection; Tumor Cells, Cultured; Tyrphostins; Up-Regulation

Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Androstadienes; Angiogenesis Inhibitors; Animals; Aspartic Acid; Cyclooxygenase Inhibitors; Cytochalasins; Enzyme Inhibitors; Flavonoids; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Imidazoles; In Vitro Techniques; Mitogen-Activated Protein Kinases; Niflumic Acid; Nitrobenzoates; Osmolar Concentration; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Pyridines; Rats; Taurine; Tritium; Tyrphostins; Wortmannin

Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Bronchi; Butadienes; Cytokines; Drug Evaluation, Preclinical; Eosinophils; Female; Flavonoids; Humans; Imidazoles; Lung Diseases, Obstructive; Male; MAP Kinase Kinase Kinase 1; Middle Aged; Mitogen-Activated Protein Kinases; Muscle, Smooth; Nitriles; p38 Mitogen-Activated Protein Kinases; Protein Serine-Threonine Kinases; Pyridines; Up-Regulation

Topics: Alkaloids; Animals; Benzophenanthridines; Benzopyrans; Carbazoles; Cell Adhesion Molecules; Cell Line, Transformed; Cysteine Proteinase Inhibitors; Endothelium; Enzyme Inhibitors; Flavonoids; Fluorescent Antibody Technique; Gene Expression; Genistein; Imidazoles; Immunoglobulins; In Vitro Techniques; Indoles; Inflammatory Bowel Diseases; Intestinal Mucosa; Isoquinolines; Leupeptins; MAP Kinase Signaling System; Mice; Mucoproteins; NF-kappa B; Phenanthridines; Pyridines; RNA, Messenger; Tumor Necrosis Factor-alpha

Topics: A Kinase Anchor Proteins; Adaptor Proteins, Signal Transducing; Animals; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; COS Cells; Enzyme Inhibitors; Estrogen Receptor beta; Flavonoids; Genes, Reporter; Humans; Imidazoles; Immunoblotting; Ligands; MAP Kinase Kinase 6; MAP Kinase Signaling System; Minor Histocompatibility Antigens; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Models, Biological; Oncogene Proteins; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Plasmids; Protein Binding; Proto-Oncogene Proteins; Pyridines; Receptors, Estrogen; RNA, Messenger; Tissue Distribution; Transcriptional Activation; Transfection; Tumor Cells, Cultured

Topics: Active Transport, Cell Nucleus; Animals; Cell Nucleus; Cells, Cultured; DNA-Binding Proteins; Electric Stimulation; Enzyme Inhibitors; Flavonoids; Genes, Reporter; Humans; Image Processing, Computer-Assisted; Imidazoles; Immunohistochemistry; MEF2 Transcription Factors; Mice; Microscopy, Confocal; Muscle Fibers, Fast-Twitch; Muscle Fibers, Skeletal; Muscle, Skeletal; Myogenic Regulatory Factors; NFATC Transcription Factors; Nuclear Proteins; Pyridines; Recombinant Fusion Proteins; Ribonucleoproteins; Serine-Arginine Splicing Factors; Time Factors; Transcription Factors

Topics: Antioxidants; Apoptosis; Cell Cycle; Cell Division; Chromones; Enzyme Inhibitors; Flavonoids; Growth Inhibitors; HeLa Cells; Humans; Imidazoles; MAP Kinase Kinase Kinase 5; MAP Kinase Kinase Kinases; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Morpholines; p38 Mitogen-Activated Protein Kinases; Paclitaxel; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-bcl-2; Pyridines; Quercetin; Signal Transduction; Tumor Cells, Cultured

Topics: Animals; Apoptosis; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Heart Ventricles; Imidazoles; Indoles; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Nitric Oxide; Nitric Oxide Donors; Oligonucleotides; p38 Mitogen-Activated Protein Kinases; Penicillamine; Protein Binding; Pyridines; Rats; Transcription Factor AP-1

Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 2; Animals; Cells, Cultured; Colforsin; Corticosterone; Cyclic AMP-Dependent Protein Kinases; Down-Regulation; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Glucocorticoids; Glucose; Hydroxysteroid Dehydrogenases; Imidazoles; Indoles; Maleimides; Mitogen-Activated Protein Kinases; Pyridines; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha

Topics: Adenocarcinoma; Animals; Cells, Cultured; Dogs; Enzyme Inhibitors; Flavonoids; Gastrins; Gene Expression; Humans; Imidazoles; Interleukin-1; Mitogen-Activated Protein Kinases; Mutagenesis; p38 Mitogen-Activated Protein Kinases; Polymerase Chain Reaction; Promoter Regions, Genetic; Protein Kinase C; Pyridines; RNA, Messenger; Stomach Neoplasms; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha

Topics: Androstadienes; Carrier Proteins; Eukaryotic Initiation Factor-4E; Flavonoids; Imidazoles; Isoquinolines; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Peptide Initiation Factors; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Pyridines; Ribosomal Protein S6 Kinases; Ribosomal Protein S6 Kinases, 90-kDa; Sirolimus; Sulfonamides; Ultraviolet Rays; Wortmannin

Topics: Animals; Carrier Proteins; Cell Differentiation; Cell Line; Chromones; Coculture Techniques; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Macrophage Colony-Stimulating Factor; MAP Kinase Kinase 1; Membrane Glycoproteins; Mice; Mice, Inbred ICR; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Morpholines; Osteoblasts; Osteoclasts; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyridines; RANK Ligand; Receptor Activator of Nuclear Factor-kappa B; Signal Transduction; Stem Cells

Topics: Animals; Anticoagulants; Arachidonic Acid; Becaplermin; Cells, Cultured; Enzyme Inhibitors; Flavonoids; Glomerular Mesangium; Hydrogen Peroxide; Imidazoles; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Oxidants; p38 Mitogen-Activated Protein Kinases; Phospholipases A; Phosphorylation; Platelet-Derived Growth Factor; Proto-Oncogene Proteins c-sis; Pyridines; Rats; Rats, Sprague-Dawley; Tritium

Topics: bcl-Associated Death Protein; Calcium-Calmodulin-Dependent Protein Kinases; Carrier Proteins; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Kinetics; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinases; Mutagenesis; Phosphoserine; Proto-Oncogene Proteins c-bcl-2; Pyridines; Recombinant Proteins; Ribosomal Protein S6 Kinases; Ribosomal Protein S6 Kinases, 90-kDa; Ultraviolet Rays

Topics: Antigens, CD; Cadherins; Capillary Permeability; Cell Membrane; Cells, Cultured; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Pyridines; Signal Transduction; Tumor Necrosis Factor-alpha

Topics: Agaricales; Animals; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Cell Communication; Cells, Cultured; Connexin 43; Enzyme Inhibitors; Epithelial Cells; Flavonoids; Gap Junctions; Hydrogen Peroxide; Imidazoles; JNK Mitogen-Activated Protein Kinases; Liver; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Plant Extracts; Pyridines; Rats; Rats, Inbred F344

Topics: Animals; Antioxidants; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Electrophoresis, Agar Gel; Electrophoretic Mobility Shift Assay; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Granulocyte-Macrophage Colony-Stimulating Factor; Hydrocortisone; Imidazoles; Interleukin-1; Interleukin-6; Keratinocytes; Mice; Mice, Inbred BALB C; NF-kappa B; Pyridines; Pyrrolidines; RNA, Messenger; Thiocarbamates; Transcription Factor AP-1; Tumor Necrosis Factor-alpha

Topics: Bronchi; Cells, Cultured; Chemokine CCL11; Chemokines, CC; Cytokines; Enzyme Inhibitors; Epithelial Cells; Flavonoids; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Imidazoles; Interleukin-8; Kinetics; Mitogen-Activated Protein Kinases; Pertussis Toxin; Phosphorylation; Pyridines; Receptors, CCR3; Receptors, Chemokine; Virulence Factors, Bordetella

Topics: Animals; Enzyme Activation; Flavonoids; Hypothermia, Induced; Imidazoles; Male; Mitogen-Activated Protein Kinases; Myocardial Ischemia; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Rats; Rats, Sprague-Dawley; Ventricular Function, Left

Topics: Activin Receptors, Type I; Activin Receptors, Type II; Adenoviridae; Animals; Bone Morphogenetic Protein 7; Bone Morphogenetic Protein Receptors, Type I; Bone Morphogenetic Proteins; Cartilage, Articular; Cattle; Cell Differentiation; Cells, Cultured; Chondrocytes; DNA-Binding Proteins; Enzyme Inhibitors; Flavonoids; Imidazoles; Mice; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphoproteins; Protein Serine-Threonine Kinases; Proteins; Pyridines; Receptors, Growth Factor; Signal Transduction; Smad Proteins; Smad1 Protein; Smad5 Protein; Smad6 Protein; Trans-Activators; Transforming Growth Factor beta; Tretinoin

Topics: Adrenergic beta-Agonists; Albuterol; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bronchi; Calcineurin Inhibitors; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line, Transformed; Chemokine CXCL1; Chemokine CXCL6; Chemokines; Chemokines, CXC; Chemotactic Factors; Cyclosporine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epithelial Cells; Flavonoids; Humans; Hydrocortisone; Imidazoles; Intercellular Signaling Peptides and Proteins; Interleukin-17; Interleukin-8; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Pyridines; Receptors, Adrenergic, beta; Receptors, Glucocorticoid

Topics: Adenocarcinoma; Carbohydrate Sequence; Down-Regulation; Enzyme Inhibitors; Epidermal Growth Factor; Flavonoids; Humans; Imidazoles; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Molecular Sequence Data; Mucin-1; Mucins; N-Acetylglucosaminyltransferases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Pyridines; Respiratory Tract Neoplasms; RNA, Messenger; Tumor Cells, Cultured

Topics: Agrin; Animals; Cell Culture Techniques; Cyclic AMP Response Element-Binding Protein; Dose-Response Relationship, Drug; Drug Interactions; Embryo, Mammalian; Enzyme Inhibitors; Flavonoids; Hippocampus; Imidazoles; Immunoblotting; Immunohistochemistry; Mitogen-Activated Protein Kinases; Neurites; Neurons; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Rats; Recombinant Proteins; Signal Transduction

Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Apigenin; Blotting, Western; Calcimycin; Calcium; Casein Kinase II; Cell Line; Cloning, Molecular; Colforsin; Cyclic AMP; Cyclic AMP Response Element Modulator; Cyclic AMP-Dependent Protein Kinase Type II; Cyclic AMP-Dependent Protein Kinases; DNA; DNA-Binding Proteins; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Enzymologic; Genetic Vectors; Imidazoles; Indoles; Interferon-gamma; Macrophages; Maleimides; Mice; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Binding; Protein Kinase C; Protein Serine-Threonine Kinases; Pyridines; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Sulfonamides; Tetradecanoylphorbol Acetate; Thapsigargin; Time Factors; Transcription, Genetic; Transcriptional Activation; Tyrphostins

Topics: Bronchi; Bronchial Hyperreactivity; Butadienes; Cell Count; Cells, Cultured; Chromones; Enzyme Inhibitors; Epithelial Cells; ErbB Receptors; Flavonoids; Goblet Cells; Humans; Imidazoles; Interleukin-13; Interleukin-4; Ion Channels; MAP Kinase Signaling System; Morpholines; Nitriles; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Pyridines

Topics: Animals; Animals, Newborn; Cell Size; Enzyme Inhibitors; Flavonoids; Hydrogen Peroxide; Imidazoles; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Myocytes, Cardiac; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Rats, Sprague-Dawley; Ribosomal Protein S6 Kinases, 70-kDa; Transcription Factor AP-1

Topics: Aorta; Cells, Cultured; Chemokine CCL2; Chemokine CCL5; Chemokines; Chemotaxis; Chromones; Dose-Response Relationship, Drug; Drug Synergism; Endothelium, Vascular; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Interleukin-8; Lysophosphatidylcholines; Mitogen-Activated Protein Kinases; Morpholines; p38 Mitogen-Activated Protein Kinases; Pertussis Toxin; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pulmonary Artery; Pyridines; Signal Transduction; Time Factors; Tumor Necrosis Factor-alpha; Umbilical Veins

Topics: Angiotensin II; Aniline Compounds; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Eukaryotic Initiation Factor-4E; Flavonoids; Imidazoles; Immunoblotting; Male; Muscle, Smooth, Vascular; Mutation; Phosphorylation; Protein Biosynthesis; Protein Serine-Threonine Kinases; Purines; Pyridines; Rats; Rats, Sprague-Dawley; Signal Transduction

Topics: Animals; Annexin A5; Anthracenes; Apoptosis; Brain; Carbofuran; Cell Survival; Cells, Cultured; Endothelium, Vascular; Flavonoids; Flow Cytometry; Imidazoles; Mice; Microcirculation; Microscopy, Electron; Mitogen-Activated Protein Kinases; Pesticides; Pyridines; Signal Transduction; Time Factors

Topics: Animals; Bombesin; Calcium-Calmodulin-Dependent Protein Kinases; Carbachol; Cholecystokinin; Cyclic AMP; Dose-Response Relationship, Drug; Elongation Factor 2 Kinase; Enzyme Inhibitors; Flavonoids; Imidazoles; Marine Toxins; Oxazoles; Pancreas; Peptide Elongation Factor 2; Peptides; Phosphorylation; Protein Biosynthesis; Pyridines; Rats; Signal Transduction; Sirolimus; Time Factors

Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Carcinogens; Cells, Cultured; Chrysenes; Enzyme Inhibitors; Epidermal Cells; Epidermis; Flavonoids; I-kappa B Proteins; Imidazoles; JNK Mitogen-Activated Protein Kinases; Mice; Mitogen-Activated Protein Kinases; NF-kappa B; Phosphorylation; Polycyclic Aromatic Hydrocarbons; Pyridines; Signal Transduction; Transcription Factor AP-1; Transcriptional Activation

Topics: Apoptosis; Carcinoma, Medullary; Cell Division; Cell Line, Tumor; CSK Tyrosine-Protein Kinase; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Genistein; Humans; Imidazoles; Mitogen-Activated Protein Kinases; Phosphorylation; Phosphotransferases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyridines; Pyrimidines; src-Family Kinases; Thyroid Neoplasms

Topics: Animals; Blotting, Western; Cell Line; Cell Survival; Chemokine CXCL2; Enzyme Activation; Enzyme Inhibitors; Epithelial Cells; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Imidazoles; Interleukin-8; Lung; Monokines; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Signal Transduction; Silicon Dioxide; src-Family Kinases

Topics: Analysis of Variance; Animals; Apoptosis; Blotting, Western; Dicumarol; Drugs, Chinese Herbal; Flavonoids; Imidazoles; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinase 9; Mitogen-Activated Protein Kinases; Neuroprotective Agents; PC12 Cells; Phosphorylation; Pyridines; Rats; Signal Transduction; Tetrazolium Salts; Thiazoles

Topics: Animals; Axonal Transport; Cell Line; Enzyme Inhibitors; Flavonoids; Imidazoles; Kinetin; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neurites; Neurofilament Proteins; Oligonucleotides, Antisense; Purines; Pyridines; Recombinant Fusion Proteins

Topics: Cell Line; Enzyme Induction; Enzyme Inhibitors; Flavonoids; Humans; Hyperglycemia; Imidazoles; Interleukin-6; MAP Kinase Signaling System; Monocytes; p38 Mitogen-Activated Protein Kinases; Protein Kinase C; Protein Kinase C beta; Protein Kinase C-alpha; Pyridines

Topics: Amino Acid Sequence; Animals; Cell Line; Enzyme Inhibitors; Epidermal Growth Factor; Flavonoids; Genes, Reporter; Histones; Humans; Imidazoles; MAP Kinase Kinase Kinases; MAP Kinase Signaling System; Mice; Molecular Sequence Data; Phosphorylation; Pyridines; Serine; Two-Hybrid System Techniques; Ultraviolet Rays

Topics: Animals; Anthracenes; Apoptosis; bcl-2-Associated X Protein; Cell Differentiation; Cell Line, Transformed; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Imidazoles; JNK Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Rats, Sprague-Dawley; Signal Transduction; Stem Cells; Telencephalon; Tumor Suppressor Protein p53

Topics: Animals; Anisomycin; Bacterial Proteins; Bacterial Toxins; Blotting, Western; Butadienes; Cyclic AMP Response Element-Binding Protein; Cyclooxygenase 2; DNA Primers; Flavonoids; Gene Expression Regulation; Imidazoles; Intestinal Mucosa; Monomeric GTP-Binding Proteins; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Rats; RNA Interference; RNA, Messenger; RNA, Small Interfering; Signal Transduction; Sorbitol

Topics: Androstadienes; Butadienes; Cells, Cultured; Chromones; Flavonoids; HIV Envelope Protein gp120; Humans; Imidazoles; Macrophages; Mitogen-Activated Protein Kinases; Morpholines; Nitriles; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Pyridines; Receptors, CCR5; RNA, Messenger; Signal Transduction; Tumor Necrosis Factor-alpha; Wortmannin

Topics: Adenoviridae; Animals; Apoptosis; Blotting, Western; Carcinoma, Non-Small-Cell Lung; Caspase 3; Caspases; Cell Line; Cell Line, Tumor; Cell Proliferation; Chromones; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Flavonoids; Flow Cytometry; Humans; Imidazoles; In Situ Nick-End Labeling; JNK Mitogen-Activated Protein Kinases; Lung Neoplasms; Mice; Mice, Nude; Mitogen-Activated Protein Kinase Kinases; Morpholines; Mutation; Oncogene Protein v-akt; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; PTEN Phosphohydrolase; Pyridines; Signal Transduction; Xenograft Model Antitumor Assays

Topics: Chromones; Dose-Response Relationship, Drug; Endotoxemia; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Flavonoids; Gene Expression Regulation, Enzymologic; Humans; Imidazoles; Inflammation; Kinetics; Leukocytes; Lipopolysaccharides; Matrix Metalloproteinase 9; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Monocytes; Morpholines; Neutrophils; p38 Mitogen-Activated Protein Kinases; Peptidoglycan; Pyridines; Pyrimidines; src-Family Kinases; Staphylococcus aureus; Time Factors

Topics: Adult; Aged; Anti-Inflammatory Agents; Cells, Cultured; Conjunctiva; Cornea; Cytokines; Doxycycline; Enzyme Inhibitors; Epithelial Cells; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Imidazoles; Interleukin-1; Interleukin-8; JNK Mitogen-Activated Protein Kinases; Middle Aged; Osmolar Concentration; Pyridines; Signal Transduction; Tumor Necrosis Factor-alpha

Topics: Angiogenesis Inducing Agents; Antigens, Surface; CCAAT-Enhancer-Binding Protein-beta; Cell Differentiation; Cells, Cultured; Chemokines; Culture Media, Conditioned; Cytokines; Dose-Response Relationship, Drug; Fetal Blood; Flavonoids; Gene Expression; Growth Substances; Humans; Imidazoles; Interleukin-1; Interleukin-6; Leptin; Mesenchymal Stem Cells; PPAR gamma; Protease Inhibitors; Protein Array Analysis; Protein Kinase Inhibitors; Pyridines; Receptors, Growth Factor; Reverse Transcriptase Polymerase Chain Reaction

Topics: 6-Ketoprostaglandin F1 alpha; Benzamides; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dexamethasone; Dinoprostone; Dose-Response Relationship, Drug; Endothelial Cells; Flavonoids; Furans; Gene Expression Regulation; Humans; Imidazoles; MAP Kinase Signaling System; Membrane Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neurokinin-1 Receptor Antagonists; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Piperidines; Protein Kinase Inhibitors; Pyridines; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; RNA, Messenger; Substance P; Time Factors; Umbilical Veins

Topics: Animals; Base Sequence; Cell Line, Tumor; DNA; Enzyme Inhibitors; Female; Flavonoids; Gene Deletion; Gene Expression Regulation; Genistein; Imidazoles; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Molecular Sequence Data; Papio; Pregnancy Proteins; Progesterone; Promoter Regions, Genetic; Pyridines; Response Elements; Signal Transduction; Transfection; Tyrphostins

Topics: Animals; Cell Membrane; Cells, Cultured; Enzyme Inhibitors; Flavonoids; Hepatocytes; Imidazoles; Magnesium; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; p38 Mitogen-Activated Protein Kinases; Pyridines; Signal Transduction; Time Factors; Transport Vesicles

Topics: Amino Acid Sequence; Base Sequence; Blotting, Northern; Breast Neoplasms; Cell Line, Tumor; Chromones; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; Insulin-Like Growth Factor Binding Proteins; Insulin-Like Growth Factor I; Mitogen-Activated Protein Kinases; Molecular Sequence Data; Morpholines; Neoplasm Proteins; Phosphoinositide-3 Kinase Inhibitors; Pyridines; Receptor, IGF Type 1; RNA, Messenger; Sequence Homology, Amino Acid; Transcription Factors; Transcription, Genetic

Topics: Apoptosis; Blotting, Western; Butadienes; Cell Line, Tumor; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Klebsiella pneumoniae; MAP Kinase Kinase 1; MAP Kinase Kinase 2; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Models, Biological; Nitriles; p38 Mitogen-Activated Protein Kinases; Pyridines; Toll-Like Receptor 2; Toll-Like Receptor 4; Virulence

Topics: Apoptosis; Autocrine Communication; Breast Neoplasms; Cell Line; Cell Line, Tumor; Cell Survival; Female; Flavonoids; Humans; Imidazoles; Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Receptors, Transforming Growth Factor beta; Signal Transduction; Transforming Growth Factor beta

Topics: Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Caspase 1; Caspase 3; Cell Culture Techniques; Cytochromes c; Enzyme Inhibitors; Epithelium, Corneal; Flavonoids; Fluorescent Antibody Technique, Indirect; Humans; Imidazoles; Infant; MAP Kinase Signaling System; Microscopy, Confocal; Mitogen-Activated Protein Kinases; Osmolar Concentration; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Saline Solution, Hypertonic

Topics: Alitretinoin; Calcium Signaling; Cell Line; Chemokines; Chemotaxis, Leukocyte; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gene Expression Regulation; Humans; Imidazoles; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Monocytes; p38 Mitogen-Activated Protein Kinases; Pyridines; Receptors, CCR1; Receptors, CCR2; Receptors, Chemokine; RNA, Messenger; Tretinoin

Topics: Animals; Carbazoles; Cell Death; Cell Survival; Cells, Cultured; Chick Embryo; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Inhibitors; Flavonoids; Imidazoles; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Myocytes, Cardiac; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Pyridines; Signal Transduction

Topics: Acetophenones; Adrenergic alpha-1 Receptor Antagonists; Anthracenes; Aorta; Apoptosis; Benzothiazoles; Cells, Cultured; Culture Media, Serum-Free; Dioxanes; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Mitochondria; Muscle, Smooth, Vascular; Phenylephrine; Piperazines; Prazosin; Pyridines; Reactive Oxygen Species; Receptors, Adrenergic, alpha-1; Time Factors; Toluene; Tumor Suppressor Protein p53

Topics: Animals; Anthracenes; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Imidazoles; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; MAP Kinase Signaling System; Nitric Oxide; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Rats; Schwann Cells

Topics: Animals; Bee Venoms; Behavior, Animal; Enzyme Inhibitors; Flavonoids; Hyperalgesia; Imidazoles; Inflammation; Injections, Subcutaneous; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Pain; Pain Measurement; Pain Threshold; Pyridines; Rats; Rats, Sprague-Dawley

Topics: Cells, Cultured; Enzyme Induction; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Flavonoids; Humans; Hydrogen Peroxide; Imidazoles; Matrix Metalloproteinase 1; Matrix Metalloproteinase 3; Matrix Metalloproteinase Inhibitors; Microscopy, Fluorescence; Oxidative Stress; Pyridines; Retinal Pigment Epithelium; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction

Topics: Androstadienes; Cell Line; Chromones; Dose-Response Relationship, Drug; Endothelial Cells; Estrenes; Fibroblast Growth Factor 2; Flavonoids; Genistein; Humans; Imidazoles; Intracellular Space; Magnesium; Microscopy, Fluorescence; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phospholipase C gamma; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyridines; Pyrrolidinones; Signal Transduction; Tyrphostins; Wortmannin

Topics: Animals; Cell Line; Cyclooxygenase 2; Dinoprostone; Enzyme Induction; Enzyme Inhibitors; Epoprostenol; Flavonoids; Imidazoles; Macrophages, Peritoneal; Mice; Mitogen-Activated Protein Kinase 3; p38 Mitogen-Activated Protein Kinases; Pyridines; Pyrroles; Quinazolines; Receptor, PAR-1; Signal Transduction; Thrombin; Thromboxane A2

Topics: Cell Line, Tumor; Chemokine CCL2; Cholesterol 7-alpha-Hydroxylase; Dextran Sulfate; Dinoprostone; Enzyme Inhibitors; Epithelial Cells; Flavonoids; Fucose; Gingiva; Humans; Imidazoles; Interleukin-1beta; Interleukin-8; Ketocholesterols; Lipoproteins, LDL; Mitogen-Activated Protein Kinases; Oxidation-Reduction; p38 Mitogen-Activated Protein Kinases; Periodontitis; Polysaccharides; Pyridines; Receptors, Scavenger; Sulfuric Acid Esters

Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Cell Shape; Cells, Cultured; Endothelin-1; Enzyme Activation; Flavonoids; Imidazoles; Mannosephosphates; Mice; Mice, Inbred C3H; Mice, Inbred DBA; Mice, Knockout; Mitogen-Activated Protein Kinases; Myocytes, Cardiac; Pioglitazone; PPAR gamma; Protein Kinase Inhibitors; Pyridines; Rats; Rats, Transgenic; Receptor, IGF Type 2; Receptors, Cytoplasmic and Nuclear; Recombinant Proteins; Renin; Thiazolidinediones; Time Factors

Topics: Androstadienes; Animals; Dose-Response Relationship, Drug; Enzyme Activation; Flavonoids; Granulocyte Colony-Stimulating Factor; Humans; Hyperalgesia; Imidazoles; Injections, Spinal; Injections, Subcutaneous; JNK Mitogen-Activated Protein Kinases; Male; MAP Kinase Signaling System; Mice; Morphine; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Pyridines; Recombinant Proteins; Spinal Cord; Wortmannin

Topics: Androstadienes; Caco-2 Cells; Dose-Response Relationship, Drug; Enterocytes; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Insulin; Mitogen-Activated Protein Kinases; Naphthalenes; Phosphatidylinositol 3-Kinases; Protein Kinase C; Pyridines; Signal Transduction; Sodium-Potassium-Exchanging ATPase; Wortmannin

Topics: Amides; Cell Movement; Cells, Cultured; Chemotaxis; Chromones; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Morpholines; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Organophosphonates; Protein Folding; Pyridines; Pyrimidines; Signal Transduction; Thrombospondin 1

Topics: Animals; Antioxidants; Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins; Cell Line; Cell Proliferation; DNA Damage; DNA-Binding Proteins; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Melatonin; Mice; Nuclear Proteins; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Promyelocytic Leukemia Protein; Protein Serine-Threonine Kinases; Pyridines; Serine; Transcription Factors; Tumor Suppressor Protein p53; Tumor Suppressor Proteins

Topics: Acetic Acid; Androstadienes; Animals; Anthracenes; Benzoquinones; Disease Models, Animal; Flavonoids; Imidazoles; Injections, Spinal; Male; MAP Kinase Signaling System; Mice; Microglia; Nociception; Nociceptive Pain; Pain; Pain Measurement; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Pyridines; Spinal Cord; Wortmannin

Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Bisbenzimidazole; Bungarotoxins; Cells, Cultured; Endothelial Cells; Enzyme Activation; Flavonoids; Heart; Imidazoles; Immunoblotting; Male; MAP Kinase Signaling System; Nicotine; p38 Mitogen-Activated Protein Kinases; Parathyroid Hormone-Related Protein; Pyridines; Rats; Rats, Wistar; Receptor, Parathyroid Hormone, Type 1; RNA, Messenger; Smoking

Topics: Androstadienes; Calcium-Calmodulin-Dependent Protein Kinases; Cell Culture Techniques; Cell Line; Dexamethasone; Dose-Response Relationship, Drug; Flavonoids; Gene Expression Regulation; Glucocorticoids; Humans; Imidazoles; Indoles; Lipopolysaccharides; Lipoxygenase Inhibitors; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Odontoblasts; p38 Mitogen-Activated Protein Kinases; Phosphoinositide-3 Kinase Inhibitors; Pyridines; RNA, Messenger; Signal Transduction; Stem Cell Factor; Time Factors; Wortmannin

Topics: Analysis of Variance; Androstadienes; Animals; Blotting, Western; Butadienes; Cell Movement; Cell Proliferation; Cells, Cultured; Chromones; Flavonoids; Glycation End Products, Advanced; Imidazoles; Intermediate-Conductance Calcium-Activated Potassium Channels; Morpholines; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nitriles; Patch-Clamp Techniques; Pyridines; Rats; RNA Interference; RNA, Small Interfering; Serum Albumin, Bovine; Signal Transduction; Wortmannin

Topics: Angiogenesis Inhibitors; Animals; Animals, Genetically Modified; Anthracenes; Cell Line, Tumor; Cell Movement; Chromones; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Glioma; High-Throughput Screening Assays; Humans; Imidazoles; Macrophages; MAP Kinase Kinase 4; Morpholines; Neovascularization, Pathologic; Phosphoinositide-3 Kinase Inhibitors; Pyridines; Signal Transduction; Transforming Growth Factor beta1; Xenograft Model Antitumor Assays; Zebrafish

Topics: Anthracenes; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Extracellular Signal-Regulated MAP Kinases; Female; Flavonoids; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; MCF-7 Cells; Myeloid Cell Leukemia Sequence 1 Protein; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; RNA Interference; RNA, Small Interfering; Superoxide Dismutase; Triple Negative Breast Neoplasms; Withanolides

Topics: Anthracenes; Cell Hypoxia; Cell Line, Tumor; Flavonoids; HMGB1 Protein; Humans; Imidazoles; MAP Kinase Signaling System; NF-kappa B; Protein Kinase Inhibitors; Pyridines; Pyrrolidines; RNA, Messenger; Thiocarbamates

Topics: Adult; Bite Force; Bone Morphogenetic Protein 2; Butadienes; Calcification, Physiologic; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprostone; Extracellular Signal-Regulated MAP Kinases; Female; Flavonoids; Humans; Imidazoles; Male; Mastication; Molar, Third; Nitriles; Nitrobenzenes; p38 Mitogen-Activated Protein Kinases; Periodontal Ligament; Protein Kinase Inhibitors; Pyridines; Signal Transduction; Stress, Physiological; Sulfonamides; Up-Regulation; Young Adult

Topics: Adiponectin; Astrocytes; Cell Line; Chemokine CCL2; Cytokines; Flavonoids; Humans; Imidazoles; Inflammation Mediators; Interleukin-1beta; Interleukin-6; Interleukin-8; MAP Kinase Signaling System; Neurodegenerative Diseases; NF-kappa B; Phenotype; Phosphatidylinositol 3-Kinases; Pyridines; Receptors, Adiponectin; RNA, Messenger

Topics: Aniline Compounds; Animals; Benzylidene Compounds; Cell Proliferation; Cells, Cultured; Ceramides; Enzyme Activation; Extracellular Matrix; Flavonoids; Imidazoles; Lysophospholipids; Matrix Metalloproteinases; Mice; Myocytes, Cardiac; p38 Mitogen-Activated Protein Kinases; Phosphotransferases (Alcohol Group Acceptor); Pyridines; Rats; Relaxin; RNA Interference; RNA, Small Interfering; Signal Transduction; Sphingolipids; Sphingosine

Topics: Alkaline Phosphatase; Animals; Anthracenes; Bone Density Conservation Agents; Cell Differentiation; Cell Proliferation; Collagen Type I; Drugs, Chinese Herbal; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gene Expression Regulation, Developmental; Imidazoles; JNK Mitogen-Activated Protein Kinases; Male; Mesenchymal Stem Cells; Osteoblasts; Osteocalcin; Osteogenesis; Osteopontin; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Primary Cell Culture; Protein Kinase Inhibitors; Pyridines; Rats; Rats, Sprague-Dawley; Signal Transduction

Topics: Animals; Bacterial Proteins; Binding Sites, Antibody; Carrier Proteins; Chemokine CXCL1; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Female; Flavonoids; Imidazoles; Immunoglobulin G; Inflammation; Interleukin-6; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Transgenic; Neutrophil Infiltration; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Pyridines; Quinazolines; Receptors, Tumor Necrosis Factor, Type I; Signal Transduction; Staphylococcal Infections; Staphylococcal Protein A; Staphylococcus aureus; Tyrphostins; Virulence Factors

Topics: Acetylcysteine; Animals; Antioxidants; Cats; Cell Survival; Cells, Cultured; Cyclooxygenase 2; Epithelial Cells; Esophageal Mucosa; Flavonoids; Fluoresceins; I-kappa B Kinase; Imidazoles; Interleukin-1beta; Mitogen-Activated Protein Kinases; NF-kappa B; Phosphorylation; Pyridines; Quercetin; Reactive Oxygen Species; Rumex; Signal Transduction

Topics: Alkaline Phosphatase; Animals; Anthracenes; Biomarkers; Cell Differentiation; Cell Line; Dexamethasone; Down-Regulation; Enzyme Inhibitors; Flavonoids; Imidazoles; Integrin-Binding Sialoprotein; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Odontoblasts; Osteogenesis; Osteopontin; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Signal Transduction; Up-Regulation

Topics: Alkaloids; Animals; Antioxidant Response Elements; Apoptosis; Catalase; Cell Cycle; Chromones; Flavonoids; Gene Expression Regulation; Glutathione Peroxidase; Imidazoles; Kelch-Like ECH-Associated Protein 1; Lipid Peroxides; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; NF-E2-Related Factor 2; NIH 3T3 Cells; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins c-akt; Pyridines; Radiation-Protective Agents; Reactive Oxygen Species; Sesquiterpenes; Signal Transduction; Superoxide Dismutase; X-Rays

Topics: Cells, Cultured; Flavonoids; Gene Expression Regulation; Humans; Imidazoles; Interleukin-1beta; Interleukin-6; Leukocytes, Mononuclear; Lymphocytes; MAP Kinase Signaling System; Nitriles; Protein Kinase Inhibitors; Pyridines; Sulfones; Trialkyltin Compounds