ro 48-8071 and squalene
ro 48-8071 has been researched along with squalene in 7 studies
Research
Studies (7)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 5 (71.43) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Aebi, JD; Dehmlow, H; Gains, N; Himber, J; Ji, YH; Lengsfeld, H; Morand, OH | 1 |
| Dang, T; Prestwich, GD | 1 |
| D'Arcy, B; Handschin, C; Kusznir, E; Morand, OH; Müller, F; Ruf, A; Stihle, M; Thoma, R | 1 |
| Abdolalipour, M; Kocarek, TA; Mercer-Haines, NA; Runge-Morris, M; Shenoy, SD; Spencer, TA; Wurster, WL | 1 |
| Balliano, G; Cravotto, G; Palmisano, G; Penoni, A; Tagliapietra, S | 1 |
| Aebi, J; Benz, J; D'Arcy, B; Dehmlow, H; Hennig, M; Ruf, A; Schulz-Gasch, T; Stihle, M; Thoma, R | 1 |
| Bach, TJ; Gas-Pascual, E; Schaller, H; Simonovik, B | 1 |
Other Studies
7 other study(ies) available for ro 48-8071 and squalene
| Article | Year |
|---|---|
Ro 48-8.071, a new 2,3-oxidosqualene:lanosterol cyclase inhibitor lowering plasma cholesterol in hamsters, squirrel monkeys, and minipigs: comparison to simvastatin.
Topics: Acetates; Animals; Apolipoproteins; Benzophenones; Cholesterol; Cricetinae; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Hydroxymethylglutaryl CoA Reductases; Intramolecular Transferases; Lanosterol; Lipoproteins; Liver; Lovastatin; Myocardium; Osmolar Concentration; Saimiri; Simvastatin; Squalene; Swine; Swine, Miniature; Triglycerides; Tumor Cells, Cultured; Ubiquinone | 1997 |
Site-directed mutagenesis of squalene-hopene cyclase: altered substrate specificity and product distribution.
Topics: Amino Acid Motifs; Amino Acid Sequence; Bacillus; Benzophenones; Binding Sites; Cyclization; Enzyme Inhibitors; Intramolecular Transferases; Kinetics; Molecular Structure; Mutagenesis, Site-Directed; Photoaffinity Labels; Squalene; Stereoisomerism; Substrate Specificity; Temperature; Triterpenes | 2000 |
The monotopic membrane protein human oxidosqualene cyclase is active as monomer.
Topics: Benzophenones; Catalysis; Cell Membrane; Cholesterol; Detergents; DNA; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Humans; Inhibitory Concentration 50; Intramolecular Transferases; Lanosterol; Ligands; Microsomes, Liver; Pichia; Recombinant Proteins; Squalene; Ultracentrifugation | 2004 |
Induction of CYP3A by 2,3-oxidosqualene:lanosterol cyclase inhibitors is mediated by an endogenous squalene metabolite in primary cultured rat hepatocytes.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzophenones; Cells, Cultured; Cytochrome P-450 CYP3A; Enzyme Induction; Hepatocytes; Intramolecular Transferases; Male; Mice; Oxidoreductases, N-Demethylating; Rats; Rats, Sprague-Dawley; RNA, Messenger; Squalene; Transfection | 2004 |
Umbelliferone aminoalkyl derivatives, a new class of squalene-hopene cyclase inhibitors.
Topics: Animals; Anticholesteremic Agents; Bacillaceae; Benzophenones; Drug Design; Enzyme Inhibitors; Intramolecular Transferases; Liver; Squalene; Swine; Umbelliferones | 2004 |
Insight into steroid scaffold formation from the structure of human oxidosqualene cyclase.
Topics: Anticholesteremic Agents; Benzophenones; Catalysis; Crystallography, X-Ray; Cyclization; Drug Design; Humans; Intramolecular Transferases; Lanosterol; Models, Molecular; Squalene; Structure-Activity Relationship | 2004 |
Inhibition of Cycloartenol Synthase (CAS) Function in Tobacco BY-2 Cells.
Topics: Arabidopsis; Benzophenones; Biosynthetic Pathways; Cell Line; Gene Silencing; Intramolecular Transferases; Nicotiana; Plant Proteins; Squalene; Sterols | 2015 |