Compounds > ro 48-8071

ro 48-8071 and squalene

ro 48-8071 has been researched along with squalene in 7 studies

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (14.29)18.2507
2000's5 (71.43)29.6817
2010's1 (14.29)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Aebi, JD; Dehmlow, H; Gains, N; Himber, J; Ji, YH; Lengsfeld, H; Morand, OH1
Dang, T; Prestwich, GD1
D'Arcy, B; Handschin, C; Kusznir, E; Morand, OH; Müller, F; Ruf, A; Stihle, M; Thoma, R1
Abdolalipour, M; Kocarek, TA; Mercer-Haines, NA; Runge-Morris, M; Shenoy, SD; Spencer, TA; Wurster, WL1
Balliano, G; Cravotto, G; Palmisano, G; Penoni, A; Tagliapietra, S1
Aebi, J; Benz, J; D'Arcy, B; Dehmlow, H; Hennig, M; Ruf, A; Schulz-Gasch, T; Stihle, M; Thoma, R1
Bach, TJ; Gas-Pascual, E; Schaller, H; Simonovik, B1

Other Studies

7 other study(ies) available for ro 48-8071 and squalene

ArticleYear
Ro 48-8.071, a new 2,3-oxidosqualene:lanosterol cyclase inhibitor lowering plasma cholesterol in hamsters, squirrel monkeys, and minipigs: comparison to simvastatin.
    Journal of lipid research, 1997, Volume: 38, Issue:2

    Topics: Acetates; Animals; Apolipoproteins; Benzophenones; Cholesterol; Cricetinae; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Hydroxymethylglutaryl CoA Reductases; Intramolecular Transferases; Lanosterol; Lipoproteins; Liver; Lovastatin; Myocardium; Osmolar Concentration; Saimiri; Simvastatin; Squalene; Swine; Swine, Miniature; Triglycerides; Tumor Cells, Cultured; Ubiquinone

1997
Site-directed mutagenesis of squalene-hopene cyclase: altered substrate specificity and product distribution.
    Chemistry & biology, 2000, Volume: 7, Issue:8

    Topics: Amino Acid Motifs; Amino Acid Sequence; Bacillus; Benzophenones; Binding Sites; Cyclization; Enzyme Inhibitors; Intramolecular Transferases; Kinetics; Molecular Structure; Mutagenesis, Site-Directed; Photoaffinity Labels; Squalene; Stereoisomerism; Substrate Specificity; Temperature; Triterpenes

2000
The monotopic membrane protein human oxidosqualene cyclase is active as monomer.
    Biochemical and biophysical research communications, 2004, Mar-05, Volume: 315, Issue:2

    Topics: Benzophenones; Catalysis; Cell Membrane; Cholesterol; Detergents; DNA; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Humans; Inhibitory Concentration 50; Intramolecular Transferases; Lanosterol; Ligands; Microsomes, Liver; Pichia; Recombinant Proteins; Squalene; Ultracentrifugation

2004
Induction of CYP3A by 2,3-oxidosqualene:lanosterol cyclase inhibitors is mediated by an endogenous squalene metabolite in primary cultured rat hepatocytes.
    Molecular pharmacology, 2004, Volume: 65, Issue:5

    Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzophenones; Cells, Cultured; Cytochrome P-450 CYP3A; Enzyme Induction; Hepatocytes; Intramolecular Transferases; Male; Mice; Oxidoreductases, N-Demethylating; Rats; Rats, Sprague-Dawley; RNA, Messenger; Squalene; Transfection

2004
Umbelliferone aminoalkyl derivatives, a new class of squalene-hopene cyclase inhibitors.
    European journal of medicinal chemistry, 2004, Volume: 39, Issue:11

    Topics: Animals; Anticholesteremic Agents; Bacillaceae; Benzophenones; Drug Design; Enzyme Inhibitors; Intramolecular Transferases; Liver; Squalene; Swine; Umbelliferones

2004
Insight into steroid scaffold formation from the structure of human oxidosqualene cyclase.
    Nature, 2004, Nov-04, Volume: 432, Issue:7013

    Topics: Anticholesteremic Agents; Benzophenones; Catalysis; Crystallography, X-Ray; Cyclization; Drug Design; Humans; Intramolecular Transferases; Lanosterol; Models, Molecular; Squalene; Structure-Activity Relationship

2004
Inhibition of Cycloartenol Synthase (CAS) Function in Tobacco BY-2 Cells.
    Lipids, 2015, Volume: 50, Issue:8

    Topics: Arabidopsis; Benzophenones; Biosynthetic Pathways; Cell Line; Gene Silencing; Intramolecular Transferases; Nicotiana; Plant Proteins; Squalene; Sterols

2015