ro 31-8220 has been researched along with pd 98059 in 44 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (18.18) | 18.2507 |
| 2000's | 35 (79.55) | 29.6817 |
| 2010's | 1 (2.27) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Caivano, M; Cohen, P; Davies, SP; Reddy, H | 1 |
| McGovern, SL; Shoichet, BK | 1 |
| Fraser, C; Morley, S | 1 |
| Engel, K; Gaestel, M; Schultz, H | 1 |
| Beale, G; Mallon, B; Morreale, A; Rumsby, M; Watson, J | 1 |
| Chen, BC; Lin, LL; Lin, WW | 1 |
| Abdel-Latif, AA; Husain, S | 1 |
| Choy, PC; Geiger, JD; Golfman, LS; Haughey, NJ; Jiang, JY; Lee, D; Wong, JT | 1 |
| Henrion, D; Lehoux, S; Lévy, BI; Loufrani, L; Tedgui, A | 1 |
| Ezumi, Y; Hirai, K; Nishida, E; Takayama, H; Uchiyama, T | 1 |
| Alam, T; Cho, CS; Hamawy, MM; Knechtle, SJ; Manthei, ER; Peters, D; Tsuchida, M | 1 |
| Akkerman, JW; Gorter, G; van Willigen, G | 1 |
| Dickenson, JM; Germack, R | 1 |
| Creuzet, C; Dupouy-Camet, J; Robert-Gangneux, F; Roisin, MP | 1 |
| Joe, E; Jou, I; Pyo, H; Ryu, J | 1 |
| Alessi, DR; Cuenda, A | 1 |
| Lin, WW; Wen, HC | 1 |
| Haskard, DO; Lidington, EA; Mason, JC | 1 |
| Chen, CC; Chen, JJ; Chou, CY | 1 |
| Huwiler, A; Johansen, B; Pfeilschifter, J; Skarstad, A | 1 |
| Beale, G; Cross, J; England, K; Rumsby, M; Warner, M; Watson, J | 1 |
| Corcos, L; Galisteo, M; Guillouzo, A; Joannard, F; Lagadic-Gossmann, D | 1 |
| Hirata , K; Inoue, N; Kawashima, S; Kojima, Y; Rikitake, Y; Shimokawa, Y; Takeuchi, S; Yokoyama, M | 1 |
| Antonini, JM; Joseph, P; Klishis, ML; Muchnok, TK; Ong , T; Roberts, JR; Whong, WZ | 1 |
| Chang, PY; Chen, CH; Henry, PD; Jiang, T; Lee, YT; Lu, SC; Luo, S | 1 |
| Haslinger, B; Mandl-Weber, S; Sellmayer, A; Sitter, T | 1 |
| Joseph, P; Muchnok, T; Ong, T | 1 |
| Barnes, PJ; Giembycz, MA; Lindsay, MA; Lynch, OT | 1 |
| Piper, HM; Rakow, A; Taimor, G | 1 |
| Chen, BC; Lin, WW | 1 |
| Benedict, CR; Katagiri, T; Pakala, R; Watanabe, T | 1 |
| Grijalva, R; Klos, K; Li, P; Nguyen, N; Xiong, S; Yao, J; Yu, D | 1 |
| Maher, P | 1 |
| Baek, SH; Chung, JH; Jeon, JY; Kim, YD; Lee, JC; Song, SY; Woo, HJ; Yoon, SK | 1 |
| Dai, J; Remick, DG; Wang, X; Zeng, X | 1 |
| DiMattina, AJ; Holland, JA; Johnson, DK; O'Donnell, RW; Stone, RI; Ziegler, LM | 1 |
| Acitores, A; González, N; Sancho, V; Valverde, I; Villanueva-Peñacarrillo, ML | 2 |
| Bae, YS; Kim, Y; Kita, H; Lee, YA; Ryu, SH; Shin, MH | 1 |
| Clugston, A; Dransfield, I; Haslett, C; Murray, J; Rossi, AG; Ward, C | 1 |
| Hemström, TH; Sandström, M; Zhivotovsky, B | 1 |
| Chang, YL; Guh, JH; Huang, DY; Pan, SL; Sun, HL; Tao, KY; Teng, CM | 1 |
| Brighente, IM; Cazarolli, LH; Folador, P; Moresco, HH; Pizzolatti, MG; Silva, FR | 1 |
| Hsu, CY; Hsu, MC; Hsu, PC; Hsu, YT; Hung, CC; Kuo, YM; Lee, YH; Lee, YJ; Lin, CH; Lin, HC; Lin, SY; Song, YP; Wang, CY | 1 |
1 review(s) available for ro 31-8220 and pd 98059
| Article | Year |
|---|---|
Use of kinase inhibitors to dissect signaling pathways.
Topics: Androstadienes; Animals; Chromones; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Indoles; Maleimides; Morpholines; Protein Kinase Inhibitors; Pyridines; Signal Transduction; Sirolimus; Wortmannin | 2000 |
43 other study(ies) available for ro 31-8220 and pd 98059
| Article | Year |
|---|---|
Specificity and mechanism of action of some commonly used protein kinase inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Alkaloids; Amides; Animals; Benzamides; Benzophenanthridines; Benzopyrans; Butadienes; Cell Line; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Indoles; Inhibitory Concentration 50; Isoquinolines; Lithium; Magnesium; Nitriles; Phenanthridines; Phosphorylation; Potassium Chloride; Protein Kinase Inhibitors; Protein Kinases; Pyridines; Sirolimus; Substrate Specificity; Sulfonamides | 2000 |
Kinase inhibitors: not just for kinases anymore.
Topics: beta-Lactamase Inhibitors; beta-Lactamases; Chymotrypsin; Enzyme Inhibitors; Kinetics; Light; Malate Dehydrogenase; Models, Biological; Phosphotransferases; Scattering, Radiation | 2003 |
Studies on the phosphorylation of eIF4E in Xenopus (XIK-2) kidney cells.
Topics: Animals; Cell Line; Enzyme Inhibitors; Eukaryotic Initiation Factor-4E; Flavonoids; Hot Temperature; Immunosuppressive Agents; Indoles; Kidney; Kinetics; Peptide Initiation Factors; Phosphorylation; Polyenes; Protein Kinase C; Sirolimus; Tetradecanoylphorbol Acetate; Xenopus | 1997 |
PMA-induced activation of the p42/44ERK- and p38RK-MAP kinase cascades in HL-60 cells is PKC dependent but not essential for differentiation to the macrophage-like phenotype.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; Enzyme Activation; Enzyme Inhibitors; Flavonoids; HL-60 Cells; Humans; Imidazoles; Indoles; Intracellular Signaling Peptides and Proteins; Macrophages; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Myelin Basic Protein; p38 Mitogen-Activated Protein Kinases; Protein Kinase C; Protein Serine-Threonine Kinases; Pyridines; Substrate Specificity; Tetradecanoylphorbol Acetate | 1997 |
Ro31-8220 inhibits protein kinase C to block the phorbol ester-stimulated release of choline- and ethanolamine-metabolites from C6 glioma cells: p70 S6 kinase and MAPKAP kinase-1beta do not function downstream of PKC in activating PLD.
Topics: Androstadienes; Animals; Choline; Enzyme Inhibitors; Ethanolamine; Flavonoids; Glioma; Indoles; Phosphoinositide-3 Kinase Inhibitors; Phospholipase D; Polyenes; Protein Kinase C; Protein Serine-Threonine Kinases; Rats; Ribosomal Protein S6 Kinases; Ribosomal Protein S6 Kinases, 90-kDa; Sirolimus; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Wortmannin | 1997 |
Protein kinase C epsilon-dependent pathway of extracellular signal-regulated protein kinase activation by P2Y1 and P2Y2 purinoceptors that activate cytosolic phospholipase A2 in endothelial cells.
Topics: Adenosine Triphosphate; Animals; Arachidonic Acid; Calcium; Cell Line; Cytosol; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Extracellular Space; Flavonoids; Indoles; Isoenzymes; Phospholipases A; Phospholipases A2; Phosphorylation; Protein Kinase C; Protein Kinase C-epsilon; Protein Kinase Inhibitors; Protein Kinases; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Receptors, Purinergic P2Y2; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Thapsigargin; Thionucleotides; Tritium; Uridine Triphosphate | 1999 |
Endothelin-1 activates p38 mitogen-activated protein kinase and cytosolic phospholipase A2 in cat iris sphincter smooth muscle cells.
Topics: Animals; Arachidonic Acid; Calcium-Calmodulin-Dependent Protein Kinases; Cats; Cells, Cultured; Cyclic AMP; Cytosol; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Endothelin-1; Enzyme Activation; Flavonoids; GTP-Binding Proteins; Imidazoles; Indoles; Intercellular Signaling Peptides and Proteins; Iris; Mitogen-Activated Protein Kinases; Muscle, Smooth; p38 Mitogen-Activated Protein Kinases; Peptides; Pertussis Toxin; Phospholipases A; Phospholipases A2; Phosphorylation; Pyridines; Receptors, Endothelin; Virulence Factors, Bordetella; Wasp Venoms | 1999 |
Lysophosphatidylcholine induces arachidonic acid release and calcium overload in cardiac myoblastic H9c2 cells.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcium; Cell Line; Enzyme Inhibitors; Flavonoids; Indoles; Isoquinolines; Kinetics; Lysophosphatidylcholines; Myocardium; Nimodipine; Phospholipases A; Protein Kinase C; Rats; Staurosporine; Structure-Activity Relationship; Sulfonamides | 1999 |
Stretch induces mitogen-activated protein kinase activation and myogenic tone through 2 distinct pathways.
Topics: Animals; Benzoquinones; Carbazoles; Enzyme Activation; Enzyme Inhibitors; Extracellular Matrix; Flavonoids; Genistein; Indoles; Lactams, Macrocyclic; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Muscle Tonus; Protein Kinase C; Quinones; Rabbits; Rifabutin; Temperature; Vasoconstriction; Veins | 1999 |
Comparative study of vanadate- and phorbol ester-induced cyclo-oxygenase-2 expression in human endothelial cells.
Topics: Cyclooxygenase 2; Endothelium, Vascular; Enzyme Activation; Enzyme Induction; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Indoles; Isoenzymes; MAP Kinase Signaling System; Membrane Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Prostaglandin-Endoperoxide Synthases; Protein Kinase C; Protein-Tyrosine Kinases; Pyridines; Tetradecanoylphorbol Acetate; Tyrphostins; Vanadates | 1999 |
Potentiation of CD3-induced expression of the linker for activation of T cells (LAT) by the calcineurin inhibitors cyclosporin A and FK506.
Topics: Adaptor Proteins, Signal Transducing; Calcimycin; Calcineurin Inhibitors; Carrier Proteins; CD28 Antigens; CD3 Complex; Cells, Cultured; Cyclosporine; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Humans; Indoles; Jurkat Cells; Lymphocyte Activation; Membrane Proteins; Phosphoproteins; Protein Kinase C; Receptor-CD3 Complex, Antigen, T-Cell; T-Lymphocytes; Tacrolimus; Transcription, Genetic | 2000 |
Thrombopoietin increases platelet sensitivity to alpha-thrombin via activation of the ERK2-cPLA2 pathway.
Topics: Animals; Blood Platelets; Carbazoles; Cattle; Cytoplasmic Granules; Drug Synergism; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Group IV Phospholipases A2; Humans; Imidazoles; Indoles; Indomethacin; Maleimides; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phospholipases A; Phospholipases A2; Phosphorylation; Platelet Aggregation; Protein Kinase C; Protein Processing, Post-Translational; Pyridines; Serotonin; Serum Albumin, Bovine; Thrombin; Thrombopoietin; Thromboxane A2 | 2000 |
Activation of protein kinase B by the A(1)-adenosine receptor in DDT(1)MF-2 cells.
Topics: Adenosine; Androstadienes; Animals; Calcium; Cell Line; Chromones; Cricetinae; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Genistein; Imidazoles; Indoles; Insulin; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Morpholines; Pertussis Toxin; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase C; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Pyridines; Receptors, Purinergic P1; Virulence Factors, Bordetella; Wortmannin; Xanthines | 2000 |
Involvement of the mitogen-activated protein (MAP) kinase signalling pathway in host cell invasion by Toxoplasma gondii.
Topics: Animals; Bombesin; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Genistein; Indoles; Mitogen-Activated Protein Kinases; Models, Biological; Signal Transduction; Tetradecanoylphorbol Acetate; Toxoplasma | 2000 |
Thrombin induces NO release from cultured rat microglia via protein kinase C, mitogen-activated protein kinase, and NF-kappa B.
Topics: Acetylcysteine; Animals; Carbazoles; Cells, Cultured; Cerebral Cortex; Enzyme Induction; Flavonoids; Imidazoles; Indoles; Maleimides; Microglia; Mitogen-Activated Protein Kinases; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Protein Kinase C; Proteins; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, PAR-1; Receptors, Thrombin; Signal Transduction; Thrombin | 2000 |
Basal cPLA(2) phosphorylation is sufficient for Ca(2+)-induced full activation of cPLA(2) in A549 epithelial cells.
Topics: Acetophenones; Arachidonic Acid; Benzopyrans; Calcium; Cell Line; Cytosol; Enzyme Activation; Enzyme Inhibitors; Epithelial Cells; Flavonoids; Humans; Indoles; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase Kinases; Mitogen-Activated Protein Kinases; Phospholipases A; Phosphorylation; Protein Kinase C; Tetradecanoylphorbol Acetate; Thapsigargin | 2000 |
Induction of decay-accelerating factor by thrombin through a protease-activated receptor 1 and protein kinase C-dependent pathway protects vascular endothelial cells from complement-mediated injury.
Topics: CD55 Antigens; Cells, Cultured; Complement Activation; Complement System Proteins; Endothelial Growth Factors; Endothelium, Vascular; Enzyme Inhibitors; Feedback; Flavonoids; Gene Expression Regulation; Humans; Imidazoles; Indoles; Inflammation; Lymphokines; Maleimides; MAP Kinase Kinase 1; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; NF-kappa B; Oligopeptides; p38 Mitogen-Activated Protein Kinases; Peptide Fragments; Protein Kinase C; Protein Serine-Threonine Kinases; Pyridines; Receptor, PAR-1; Receptors, Thrombin; Recombinant Proteins; RNA, Messenger; Thrombin; Thrombosis; Umbilical Veins; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2000 |
Protein kinase calpha but not p44/42 mitogen-activated protein kinase, p38, or c-Jun NH(2)-terminal kinase is required for intercellular adhesion molecule-1 expression mediated by interleukin-1beta: involvement of sequential activation of tyrosine kinase,
Topics: Bridged-Ring Compounds; Cells, Cultured; Enzyme Inhibitors; Flavonoids; Fluorescent Antibody Technique; Gene Expression; Humans; I-kappa B Kinase; Imidazoles; Indoles; Intercellular Adhesion Molecule-1; Interleukin-1; Isoenzymes; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Mutation; Naphthalenes; NF-kappaB-Inducing Kinase; Norbornanes; p38 Mitogen-Activated Protein Kinases; Protein Kinase C; Protein Kinase C-alpha; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Pyridines; Staurosporine; Thiocarbamates; Thiones; Tyrphostins | 2000 |
Ceramide binds to the CaLB domain of cytosolic phospholipase A2 and facilitates its membrane docking and arachidonic acid release.
Topics: Animals; Arachidonic Acid; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Catalytic Domain; Cell Line; Cell Membrane; Ceramides; Cytosol; Flavonoids; Glomerular Mesangium; Indoles; Liposomes; MAP Kinase Signaling System; Models, Biological; Mutation; Phospholipases A; Phospholipases A2; Protein Binding; Protein Kinase C; Protein Structure, Tertiary; Sphingomyelin Phosphodiesterase | 2001 |
Signalling pathways regulating the dephosphorylation of Ser729 in the hydrophobic domain of protein kinase Cepsilon upon cell passage.
Topics: 3T3 Cells; Alkaloids; Animals; Anti-Bacterial Agents; Benzophenanthridines; Blotting, Western; Calcineurin; Cell Adhesion; Cell Line; Culture Media; Cyclosporine; Down-Regulation; Enzyme Inhibitors; Flavonoids; Indoles; Isoenzymes; MAP Kinase Signaling System; Marine Toxins; Methionine; Mice; Models, Biological; Okadaic Acid; Oxazoles; Phenanthridines; Phosphoprotein Phosphatases; Phosphorylation; Plasmids; Precipitin Tests; Protein Binding; Protein Kinase C; Protein Kinase C-epsilon; Protein Structure, Tertiary; Serine; Signal Transduction; Sirolimus; Tacrolimus; Transfection | 2001 |
Regulation of phenobarbital-induction of CYP2B and CYP3A genes in rat cultured hepatocytes: involvement of several serine/threonine protein kinases and phosphatases.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aryl Hydrocarbon Hydroxylases; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Chromones; Cyclic AMP; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Enzyme Induction; Enzyme Inhibitors; Flavonoids; Genistein; Hepatocytes; Hydroquinones; Indoles; Intracellular Fluid; Morpholines; Okadaic Acid; Oxidoreductases, N-Demethylating; Phenobarbital; Phosphoric Monoester Hydrolases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Rats; RNA, Messenger; Signal Transduction | 2000 |
Signaling mechanism underlying COX-2 induction by lysophosphatidylcholine.
Topics: Activating Transcription Factor 1; Animals; Cattle; Cells, Cultured; Cyclic AMP Response Element-Binding Protein; Cyclooxygenase 2; DNA-Binding Proteins; Endothelium, Vascular; Enzyme Induction; Enzyme Inhibitors; Flavonoids; Imidazoles; Indoles; Isoenzymes; Isoquinolines; Lysophosphatidylcholines; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Prostaglandin-Endoperoxide Synthases; Pyridines; RNA, Messenger; Sulfonamides; Transcription Factors; Up-Regulation | 2001 |
Cadmium-induced cell transformation and tumorigenesis are associated with transcriptional activation of c-fos, c-jun, and c-myc proto-oncogenes: role of cellular calcium and reactive oxygen species.
Topics: 3T3 Cells; Analysis of Variance; Animals; Blotting, Northern; Cadmium; Calcium; Cell Transformation, Neoplastic; Dactinomycin; Egtazic Acid; Flavonoids; Free Radical Scavengers; Gene Expression Regulation, Neoplastic; Genes, fos; Genes, jun; Genes, myc; Indoles; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinase Kinases; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; RNA; Tumor Cells, Cultured | 2001 |
Oxidized low-density lipoprotein downregulates endothelial basic fibroblast growth factor through a pertussis toxin-sensitive G-protein pathway: mediator role of platelet-activating factor-like phospholipids.
Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Animals; Azepines; Blotting, Northern; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Cattle; Cells, Cultured; Chelating Agents; Cyclic AMP-Dependent Protein Kinases; Down-Regulation; Egtazic Acid; Endothelium, Vascular; Enzyme Inhibitors; Fibroblast Growth Factor 2; Flavonoids; GTP-Binding Proteins; Indoles; Isoquinolines; Lipoproteins, LDL; Pertussis Toxin; Phospholipases A; Platelet Activating Factor; Protein Kinase C; Recombinant Proteins; RNA, Messenger; Signal Transduction; Sulfonamides; Triazoles; Virulence Factors, Bordetella | 2001 |
Hyaluronan fragments induce the synthesis of MCP-1 and IL-8 in cultured human peritoneal mesothelial cells.
Topics: Adjuvants, Immunologic; Cells, Cultured; Chemokine CCL2; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epithelium; Flavonoids; Gene Expression; Humans; Hyaluronan Receptors; Hyaluronic Acid; Indoles; Interleukin-8; MAP Kinase Signaling System; Molecular Weight; NF-kappa B; Peptide Fragments; Peritoneal Dialysis; Peritoneum; Protein Kinase C; RNA, Messenger; Transcription Factor AP-1 | 2001 |
Gene expression profile in BALB/c-3T3 cells transformed with beryllium sulfate.
Topics: 3T3 Cells; Animals; Beryllium; Calcium-Calmodulin-Dependent Protein Kinases; Catalase; Cell Transformation, Neoplastic; Dactinomycin; DNA, Neoplasm; Enzyme Inhibitors; Flavonoids; Gene Expression; Gene Expression Profiling; Indoles; Mice; Mice, Inbred BALB C; Mice, Nude; Oligonucleotide Array Sequence Analysis; Protein Kinase C; Proto-Oncogene Proteins; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; RNA; Superoxide Dismutase | 2001 |
Pharmacological comparison of LTB(4)-induced NADPH oxidase activation in adherent and non-adherent guinea-pig eosinophils.
Topics: Androstadienes; Animals; Antibodies; Carbazoles; CD18 Antigens; Cell Adhesion; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Enzyme Precursors; Eosinophils; Flavonoids; Guinea Pigs; Imidazoles; Indoles; Integrin beta1; Intracellular Signaling Peptides and Proteins; Leukotriene B4; Macrophage-1 Antigen; Male; Maleimides; Mitogen-Activated Protein Kinases; NADPH Oxidases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Protein-Tyrosine Kinases; Pyrazoles; Pyridines; Pyrimidines; Rats; src-Family Kinases; Stilbenes; Syk Kinase; Time Factors; Wortmannin | 2001 |
Transcription activator protein 1 (AP-1) mediates NO-induced apoptosis of adult cardiomyocytes.
Topics: Animals; Apoptosis; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Heart Ventricles; Imidazoles; Indoles; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Nitric Oxide; Nitric Oxide Donors; Oligonucleotides; p38 Mitogen-Activated Protein Kinases; Penicillamine; Protein Binding; Pyridines; Rats; Transcription Factor AP-1 | 2001 |
PKC- and ERK-dependent activation of I kappa B kinase by lipopolysaccharide in macrophages: enhancement by P2Y receptor-mediated CaMK activation.
Topics: Animals; Benzylamines; Bridged-Ring Compounds; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Enzyme Activation; Enzyme Inhibitors; Flavonoids; I-kappa B Kinase; I-kappa B Proteins; Imidazoles; Indoles; Lipopolysaccharides; Macrophages; Macrophages, Peritoneal; Mitogen-Activated Protein Kinases; NF-kappa B; Norbornanes; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase C; Protein Serine-Threonine Kinases; Pyridines; Receptors, Purinergic P2; Sulfonamides; Thapsigargin; Thiocarbamates; Thiones; Time Factors; Transcription Factor RelA; Uridine Triphosphate | 2001 |
Synergistic effect of urotensin II with serotonin on vascular smooth muscle cell proliferation.
Topics: Animals; Cell Count; Cell Division; Cells, Cultured; DNA; Drug Synergism; Enzyme Inhibitors; Flavonoids; Guanosine Diphosphate; Indoles; Male; Mitogens; Muscle, Smooth, Vascular; Rabbits; Serotonin; Thionucleotides; Urotensins | 2001 |
Multiple signaling pathways involved in activation of matrix metalloproteinase-9 (MMP-9) by heregulin-beta1 in human breast cancer cells.
Topics: Breast Neoplasms; Enzyme Activation; Enzyme Inhibitors; Female; Flavonoids; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; Indoles; Matrix Metalloproteinase 9; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Models, Biological; Neoplasm Invasiveness; Neuregulin-1; p38 Mitogen-Activated Protein Kinases; Protein Kinase C; Pyridines; RNA, Neoplasm; Signal Transduction; Transcriptional Activation; Tumor Cells, Cultured | 2001 |
Phorbol esters inhibit fibroblast growth factor-2-stimulated fibroblast proliferation by a p38 MAP kinase dependent pathway.
Topics: 3T3 Cells; Animals; Cell Division; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fibroblast Growth Factor 2; Fibroblasts; Flavonoids; Imidazoles; Indoles; Isoenzymes; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Protein Kinase C; Pyridines; Tetradecanoylphorbol Acetate; Time Factors | 2002 |
Interleukin-1beta induces MUC2 gene expression and mucin secretion via activation of PKC-MEK/ERK, and PI3K in human airway epithelial cells.
Topics: Cell Line; Chromones; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Epithelium; Flavonoids; Humans; Imidazoles; Immunoassay; Immunoblotting; Indoles; Interleukin-1; Lung; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Morpholines; Mucin-2; Mucins; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Kinase C; Protein Structure, Tertiary; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Time Factors | 2002 |
Homocysteine mediated expression and secretion of monocyte chemoattractant protein-1 and interleukin-8 in human monocytes.
Topics: Antioxidants; Cells, Cultured; Chemokine CCL2; Chromans; Dimethyl Sulfoxide; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Genistein; Homocysteine; Humans; Imidazoles; Indoles; Interleukin-8; Monocytes; Naphthalenes; Onium Compounds; Pyridines; Pyrrolidines; Reactive Oxygen Species; RNA, Messenger; Sulfonamides; Thiazoles; Thiazolidinediones; Thiocarbamates; Time Factors; Troglitazone; Tyrphostins | 2003 |
Endothelial NADPH oxidase: mechanism of activation by low-density lipoprotein.
Topics: Arachidonic Acids; Cells, Cultured; Chromones; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Estrenes; Flavonoids; Humans; Imidazoles; Indoles; Lipoproteins, LDL; Maleimides; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Morpholines; NADPH Oxidases; p38 Mitogen-Activated Protein Kinases; Pertussis Toxin; Phosphatidylinositol 3-Kinases; Phospholipase C gamma; Phospholipases A; Protein Kinase C; Pyridines; Pyrrolidinones; Reactive Oxygen Species; Signal Transduction; src-Family Kinases; Type C Phospholipases; Umbilical Veins | 2003 |
Cell signalling of glucagon-like peptide-1 action in rat skeletal muscle.
Topics: Androstadienes; Animals; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Glucagon; Glucagon-Like Peptide 1; Glycogen Synthase; In Vitro Techniques; Indoles; Insulin; Mitogen-Activated Protein Kinases; Muscle, Skeletal; Okadaic Acid; Peptide Fragments; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoprotein Phosphatases; Protein Phosphatase 1; Protein Precursors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Sirolimus; Tumor Necrosis Factor-alpha; Wortmannin | 2004 |
Effect of GLP-1 on glucose transport and its cell signalling in human myocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aged; Aged, 80 and over; Androstadienes; Biological Transport; Cells, Cultured; Enzyme Activation; Exenatide; Female; Flavonoids; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; Indoles; Insulin; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Muscle Cells; Peptide Fragments; Peptides; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Protein Precursors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Sirolimus; Venoms; Wortmannin | 2005 |
The synthetic chemoattractant peptide WKYMVm induces superoxide production by human eosinophils via the phosphoinositide 3-kinase-mediated activation of ERK1/2.
Topics: Blotting, Western; Chromones; Enzyme Activation; Enzyme Inhibitors; Eosinophil Granule Proteins; Eosinophils; Flavonoids; Humans; Indoles; Mitogen-Activated Protein Kinase 3; Morpholines; Oligopeptides; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Signal Transduction; Stereoisomerism; Superoxides | 2005 |
Interleukin-10 inhibits lipopolysaccharide-induced survival and extracellular signal-regulated kinase activation in human neutrophils.
Topics: Apoptosis; Blotting, Western; Chromones; Drug Interactions; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Flow Cytometry; Humans; Imidazoles; Indoles; Interleukin-10; Lipopolysaccharides; Morpholines; Neutrophils; NF-kappa B; Phosphatidylinositol 3-Kinases; Protein Kinase C; Protein Kinase Inhibitors; Pyridines | 2005 |
Inhibitors of the PI3-kinase/Akt pathway induce mitotic catastrophe in non-small cell lung cancer cells.
Topics: Androstadienes; Antineoplastic Agents; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Cycle; Cell Survival; Chromones; Enzyme Inhibitors; Etoposide; Flavonoids; Flow Cytometry; Humans; Indoles; Lung Neoplasms; MAP Kinase Kinase Kinases; Mitosis; Morpholines; Nocodazole; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Signal Transduction; Staurosporine; Wortmannin | 2006 |
The p38 mitogen-activated protein kinase pathway plays a critical role in PAR2-induced endothelial IL-8 production and leukocyte adhesion.
Topics: Activating Transcription Factors; Blotting, Western; Cell Adhesion; Cells, Cultured; DNA, Complementary; Flavonoids; Flow Cytometry; Humans; Imidazoles; Indoles; Integrin alpha4beta1; Intercellular Adhesion Molecule-1; Interleukin-8; Leukocytes; Lymphocyte Function-Associated Antigen-1; Macrophage-1 Antigen; p38 Mitogen-Activated Protein Kinases; Pyridines; Receptor, PAR-2; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Trypsin; Vascular Cell Adhesion Molecule-1 | 2008 |
Mechanism of action of the stimulatory effect of apigenin-6-C-(2''-O-alpha-l-rhamnopyranosyl)-beta-L-fucopyranoside on 14C-glucose uptake.
Topics: Alloxan; Androstadienes; Animals; Biological Transport; Blood Glucose; Carbon Radioisotopes; Colchicine; Cycloheximide; Diabetes Mellitus, Experimental; Disaccharides; Disease Models, Animal; Dose-Response Relationship, Drug; Flavones; Flavonoids; Glucose; Hyperglycemia; Indoles; Insulin; Insulin Secretion; Magnoliopsida; Male; Muscle, Skeletal; Plant Leaves; Rats; Rats, Wistar; Tissue Distribution; Wortmannin | 2009 |
Protein kinase C-dependent growth-associated protein 43 phosphorylation regulates gephyrin aggregation at developing GABAergic synapses.
Topics: Animals; Carrier Proteins; Cells, Cultured; Female; Flavonoids; GABAergic Neurons; GAP-43 Protein; HEK293 Cells; Humans; Indoles; Membrane Proteins; Phosphorylation; Pregnancy; Protein Folding; Protein Kinase C; Rats; Rats, Sprague-Dawley | 2015 |