Compounds > ramelteon
Page last updated: 2024-09-05

ramelteon and s20098

ramelteon has been researched along with s20098 in 20 studies

Compound Research Comparison

Studies
(ramelteon)		Trials
(ramelteon)		Recent Studies (post-2010)
(ramelteon)		Studies
(s20098)		Trials
(s20098)		Recent Studies (post-2010) (s20098)
3175920462487422

Protein Interaction Comparison

ProteinTaxonomyramelteon (IC50)s20098 (IC50)
Melatonin receptor type 1AHomo sapiens (human)0.0001
Melatonin receptor type 1BHomo sapiens (human)0.0001

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's7 (35.00)29.6817
2010's11 (55.00)24.3611
2020's2 (10.00)2.80

Authors

AuthorsStudies
Chandrasena, G; Doller, D; Jiang, Y; Keim, H; Li, G; Poda, SB; Ren, Y; Topiol, SW; Zhou, H1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Gillette, MU; Turek, FW1
Steinhilber, D1
Cardinali, DP; Hardeland, R; Pandi-Perumal, SR; Poeggeler, B; Srinivasan, V; Trakht, I1
Cardinali, DP; Hardeland, R; Pandi-Perumal, SR; Poeggeler, B; Spence, DW; Srinivasan, V; Trakht, I1
Arendt, J; Rajaratnam, SM1
Cardinali, DP; Hardeland, R; Pandi-Perumal, SR; Poeggeler, B; Spence, DW; Srinivasan, V; Trahkt, I1
Cespuglio, R; Delagrange, P; Descamps, A; Millan, M; Millan, MJ; Rousset, C; Spedding, M1
Dawson, D; Ferguson, SA; Rajaratnam, SM1
Brown, GM; Cardinali, DP; Pandi-Perumal, SR; Singh, J; Spence, DW; Srinivasan, V1
Brown, GM; Brzezinski, A; Cardinali, DP; Pandi-Perumal, SR; Spence, DW; Srinivasan, V1
Brown, GM; Brzezinski, A; Cardinali, DP; Srinivasan, V1
Bellantuono, C; Catena-Dell'Osso, M; Marazziti, D; Rotella, F1
Hardeland, R; Poeggeler, B1
Zlotos, DP1
Frydman-Marom, A; Laudon, M1
Batyuk, A; Brehm, W; Cherezov, V; Gati, C; Grandner, JM; Grant, TD; Han, GW; Huang, XP; Ishchenko, A; Johansson, LC; Katritch, V; Liu, W; Madsen, C; McCorvy, JD; Michaelian, N; Olsen, RHJ; Patel, N; Roth, BL; Shiriaeva, A; Slocum, ST; Stauch, B; Stevens, RC; Tribo, AR; Weierstall, U; White, TA; Yous, S; Zhu, L1
Aydın, A; Gürbüz, MA; Halıcı, Z; Karaman, A; Köse, A; Köse, D; Toktay, E; Ugan, RA1
Bomsel, M; Cecon, E; Dam, J; Ghigna, MR; Izabelle, C; Jockers, R; Klonjkowski, B; Poder, SL; Real, F; Tu, L; Zhu, A1

Reviews

13 review(s) available for ramelteon and s20098

ArticleYear
Melatonin, sleep, and circadian rhythms: rationale for development of specific melatonin agonists.
    Sleep medicine, 2004, Volume: 5, Issue:6

    Topics: Acetamides; Antioxidants; Humans; Hypothalamus; Indenes; Indoles; Melatonin; Receptors, Melatonin; Sleep Disorders, Circadian Rhythm

2004
[Melatonin, melatonin receptor agonists and tryptophan as sleep aids].
    Pharmazie in unserer Zeit, 2007, Volume: 36, Issue:3

    Topics: Acetamides; Animals; Antioxidants; Humans; Hypnotics and Sedatives; Indenes; Melatonin; Receptors, Melatonin; Sleep Wake Disorders; Tryptophan

2007
Melatonergic drugs in clinical practice.
    Arzneimittel-Forschung, 2008, Volume: 58, Issue:1

    Topics: Acetamides; Animals; Antidepressive Agents; Biological Clocks; Humans; Hypnotics and Sedatives; Indenes; Melatonin; Receptors, Melatonin; Sleep Initiation and Maintenance Disorders

2008
The effect of melatonergic and non-melatonergic antidepressants on sleep: weighing the alternatives.
    The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry, 2009, Volume: 10, Issue:4 Pt 2

    Topics: Acetamides; Affect; Antidepressive Agents; Brain; Depressive Disorder, Major; Humans; Indenes; Melatonin; Receptor, Melatonin, MT1; Receptor, Melatonin, MT2; Selective Serotonin Reuptake Inhibitors; Serotonin 5-HT2 Receptor Antagonists; Serotonin Antagonists; Sleep; Sleep Initiation and Maintenance Disorders

2009
Melatonin and melatonergic drugs on sleep: possible mechanisms of action.
    The International journal of neuroscience, 2009, Volume: 119, Issue:6

    Topics: Acetamides; Aging; Animals; Antidepressive Agents; Circadian Rhythm; Depressive Disorder; Humans; Hypnotics and Sedatives; Indenes; Melatonin; Receptors, Melatonin; Signal Transduction; Sleep; Sleep Initiation and Maintenance Disorders; Suprachiasmatic Nucleus

2009
Melatonin agonists and insomnia.
    Expert review of neurotherapeutics, 2010, Volume: 10, Issue:2

    Topics: Acetamides; Animals; Benzofurans; Circadian Rhythm; Cyclopropanes; Humans; Hypnotics and Sedatives; Indenes; Melatonin; Sleep Initiation and Maintenance Disorders

2010
Jet lag, circadian rhythm sleep disturbances, and depression: the role of melatonin and its analogs.
    Advances in therapy, 2010, Volume: 27, Issue:11

    Topics: Acetamides; Benzofurans; Central Nervous System Depressants; Cyclopropanes; Depressive Disorder; Humans; Indenes; Jet Lag Syndrome; Melatonin; Sleep Disorders, Circadian Rhythm

2010
Melatonin agonists in primary insomnia and depression-associated insomnia: are they superior to sedative-hypnotics?
    Progress in neuro-psychopharmacology & biological psychiatry, 2011, Jun-01, Volume: 35, Issue:4

    Topics: Acetamides; Animals; Benzodiazepines; Benzofurans; Clinical Trials as Topic; Cyclopropanes; Depressive Disorder; Humans; Hypnotics and Sedatives; Indenes; Indoles; Melatonin; Sleep Initiation and Maintenance Disorders

2011
Melatonin and its analogs in insomnia and depression.
    Journal of pineal research, 2012, Volume: 52, Issue:4

    Topics: Acetamides; Animals; Depression; Humans; Hypnotics and Sedatives; Indenes; Melatonin; Mice; Sleep Initiation and Maintenance Disorders

2012
Emerging targets for the pharmacological treatment of depression: focus on melatonergic system.
    Current medicinal chemistry, 2012, Volume: 19, Issue:3

    Topics: Acetamides; Antidepressive Agents; Circadian Clocks; Depression; Humans; Indenes; Melatonin; Receptors, Melatonin

2012
Melatonin and synthetic melatonergic agonists: actions and metabolism in the central nervous system.
    Central nervous system agents in medicinal chemistry, 2012, Volume: 12, Issue:3

    Topics: Acetamides; Animals; Antidepressive Agents; Central Nervous System; Humans; Indenes; Melatonin; Receptors, Melatonin; Sleep

2012
Recent progress in the development of agonists and antagonists for melatonin receptors.
    Current medicinal chemistry, 2012, Volume: 19, Issue:21

    Topics: Acetamides; Animals; Benzofurans; Cyclopropanes; Humans; Indenes; Molecular Structure; Receptors, Melatonin; Structure-Activity Relationship

2012
Therapeutic effects of melatonin receptor agonists on sleep and comorbid disorders.
    International journal of molecular sciences, 2014, Sep-09, Volume: 15, Issue:9

    Topics: Acetamides; Animals; Benzofurans; Clinical Trials as Topic; Cyclopropanes; Humans; Hypnotics and Sedatives; Indenes; Melatonin; Neurodegenerative Diseases; Receptors, Melatonin; Sleep Wake Disorders

2014

Other Studies

7 other study(ies) available for ramelteon and s20098

ArticleYear
Design and synthesis of 4-arylpiperidinyl amide and N-arylpiperdin-3-yl-cyclopropane carboxamide derivatives as novel melatonin receptor ligands.
    Bioorganic & medicinal chemistry letters, 2011, Feb-15, Volume: 21, Issue:4

    Topics: Amides; Animals; Cyclopropanes; Drug Design; Humans; Ligands; Microsomes; Piperidines; Rats; Receptor, Melatonin, MT1; Receptor, Melatonin, MT2; Structure-Activity Relationship

2011
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Melatonin and its agonists: an update.
    The British journal of psychiatry : the journal of mental science, 2008, Volume: 193, Issue:4

    Topics: Acetamides; Benzofurans; Cyclopropanes; Drug Administration Schedule; Humans; Indenes; Melatonin; Receptors, Melatonin

2008
Influence of the novel antidepressant and melatonin agonist/serotonin2C receptor antagonist, agomelatine, on the rat sleep-wake cycle architecture.
    Psychopharmacology, 2009, Volume: 205, Issue:1

    Topics: Acetamides; Analysis of Variance; Animals; Behavior, Animal; Central Nervous System Depressants; Circadian Rhythm; Hypnotics and Sedatives; Indenes; Indoles; Melatonin; Pyridines; Rats; Rats, Wistar; Serotonin Antagonists; Sleep; Wakefulness

2009
Structural basis of ligand recognition at the human MT
    Nature, 2019, Volume: 569, Issue:7755

    Topics: Acetamides; Amino Acid Sequence; Antidepressive Agents; Crystallization; Electrons; Humans; Indenes; Lasers; Ligands; Melatonin; Models, Molecular; Molecular Docking Simulation; Mutation; Receptor, Melatonin, MT1; Receptor, Serotonin, 5-HT2C; Structure-Activity Relationship; Substrate Specificity

2019
Do peripheral melatonin agonists improve bone fracture healing? The effects of agomelatine and ramelteon on experimental bone fracture.
    European journal of pharmacology, 2020, Nov-15, Volume: 887

    Topics: Acetamides; Animals; Femoral Fractures; Fracture Healing; Fractures, Bone; Indenes; Male; Melatonin; Osteogenesis; Polymerase Chain Reaction; Rats; Rats, Wistar; RNA, Messenger; X-Rays

2020
Therapeutic potential of melatonin and melatonergic drugs on K18-hACE2 mice infected with SARS-CoV-2.
    Journal of pineal research, 2022, Volume: 72, Issue:1

    Topics: Acetamides; Animals; COVID-19; COVID-19 Drug Treatment; Indenes; Lung; Melatonin; Mice; Mice, Inbred C57BL; Mice, Transgenic; SARS-CoV-2; Viral Load

2022
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