Page last updated: 2024-09-02

r 56865 and piperidines

r 56865 has been researched along with piperidines in 70 studies

Compound Research Comparison

Studies (r 56865)	Trials (r 56865)	Recent Studies (post-2010) (r 56865)	Studies (piperidines)	Trials (piperidines)	Recent Studies (post-2010) (piperidines)
72	1	0	40,235	5,221	14,545

Research

Studies (70)

Timeframe	Studies, this research(%)	All Research%
pre-1990	4 (5.71)	18.7374
1990's	63 (90.00)	18.2507
2000's	3 (4.29)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Frankow, C; Peters, T; Tegtmeier, F; Thoné, F; Vandeplassche, L; Wilhelm, D	1
Haigney, MC; Lakatta, EG; Miyata, H; Silverman, HS; Stern, MD	1
Leidig, A; Nebel, U; Peters, T; Wermelskirchen, D; Wilffert, B; Wirth, A	1
Heers, C; Peters, T; Scheufler, E; Wermelskirchen, D; Wilffert, B; Wilhelm, D	1
Daniels, MC; ter Keurs, HE	1
Gwilt, M; Henderson, CG; Orme, J; Rourke, JD	1
Borgers, M; Geerts, H; Ver Donck, L; Verellen, G	1
Beile, A; Guttmann, I; Osikowska-Evers, B; Peters, T; Scheufler, E; Tegtmeier, F; Urenjak, J; Wilffert, B	1
Law, RO	1
Gleitz, J; Peters, T; Tegtmeier, F; Urenjak, J; Wermelskirchen, D; Wilffert, B	1
Bernier, M; Borgers, M; Hearse, DJ; Kusama, Y; Neckers, DC; Valdes-Aguilera, O; Ver Donck, L	1
Carmeliet, E; Tytgat, J	1
Borgers, M; Ver Donck, L	1
Bielen, FV; Ver Donck, L; Verdonck, F	1
Nebel, U; Peters, T; Wermelskirchen, D; Wilffert, B; Wirth, A	1
Himmel, H; Peters, T; Ravens, U; Wilhelm, D	1
Borgers, M; Thoné, F; Vandeplassche, G	1
Bernier, M; Garner, JA; Hearse, DJ	1
Himmel, HM; Ravens, U; Wilhelm, D	1
Peters, T; Scheufler, E; Wilhelm, D	1
Borgers, M; Hermans, C; Vandeplassche, G; Wouters, L	1
Damiano, BP; Stump, GL; Yagel, SK	1
Carmeliet, E; Leyssens, A	1
Nebel, U; Wermelskirchen, D; Wilffert, B; Wirth, A	1
Carmeliet, E; Luk, HN	1
Chapman, RA; Rodrigo, GC	1
Scheufler, E; Vogelgesang, R	1
Peters, T; Scheufler, E	1
Borgers, M; De Clerck, F; Vandewiele, R; Ver Donck, L; Verellen, G	1
Koch, P; Peters, T; Wilffert, B; Wilhelm, D	1
Bravo, G; Finet, M; Godfraind, T	1
Koch, P; Nebel, U; Peters, T; Wermelskirchen, D; Wilffert, B; Wilhelm, D	1
Janssen, PA; Meuter, C; Vollmer, B	1
Hoff, P; Tegtmeier, F; Xie, Y; Zacharias, E	1
Coraboeuf, E; John, GW; Le Grand, B; Talmant, JM; Vie, B	1
Park, SR; Ryu, GH; Suh, CK	1
David, GK; Koch, K; Koolen, JJ; Piek, JJ; Pijl, AJ; Swaan, A; Van Wezel, HB; Van Zwieten, PA; Visser, CA	1
De Clerck, F; Lu, HR	1
McGarry, SJ; Scheufler, E; Williams, AJ	1
De Courtois, F; John, GW; Le Grand, B; Pouget, G; Verscheure, Y	1
Klein, HH; Lindert-Heimberg, S; Maisch, B; Nebendahl, K; Pich, S	1
Hendriks, MG; Kam, KL; Paffendorf, M; Pijl, AJ; van Zwieten, PA	1
Bindels, RJ; Couwenberg, P; Jansen, JW; Rose, UM; Van Os, CH	1
Haigney, MC; Lakatta, EG; Silverman, HS; Stern, MD	1
Coetzee, WA; Hearse, DJ; Ichikawa, H	1
Borgers, M; Chen, CC; Flameng, W; Lin, W; Masuda, M; Morishige, N; Mubagwa, K; Thoné, F; Wieland, W	1
Gorgels, AP; Leunissen, JD; van Deursen, RT; Vos, MA; Wellens, HJ	1
Coronel, R; Janse, MJ; Mazón, P; Netea, AO; Opthof, T; Sleeswijk, ME; Tan, HL	1
Heers, C; Peters, T; Pierce, GN; Scheufler, E; Wilffert, B	1
Albillos, A; Artalejo, AR; de la Fuente, MT; Gandía, L; Garcez-Do-Carmo, L; García, AG; López, MG; Michelena, P	1
Krishtal, OA; Panchenko, VA; Tegtmeier, F	1
Borgers, M; Ver Donck, L; Verdonck, F	1
Chizhmakov, IV; Kiskin, NI; Krishtal, OA; Tegtmeier, F	1
De Clerck, F; Lu, HR; Remeysen, P	1
Guttmann, I; Mozes, A; Scheufler, E; Wilffert, B	1
Cambarrat, C; Iliou, JP; Robin, F; Thollon, C; Vilaine, JP	1
Kellerman, TS; Maartens, BP; Mülders, MS; Schultz, RA; Swan, GE; Van der Walt, JJ	1
Ishide, N	1
De la Fuente, MT; Esquerro, E; García, AG; Maroto, R; Sánchez-García, P	1
Adachi, Y; Akima, M; Fukazawa, M; Kato, T; Koga, T; Kuromaru, O; Suzuki, Y; Tamura, K	1
Coulombe, A; John, GW; Le Grand, B	1
Dai, DZ; De Clerck, F; Lu, HR; Remeysen, P; Saels, A; Yang, P	1
Adachi, Y; Fukazawa, M; Homma, N; Kuromaru, O; Nishie, I; Suzuki, Y; Tamura, K	1
Himmel, HM; Ravens, U	1
Lawrence, C; Rodrigo, GC	1
Barbieri, M; Nistri, A	1
Arita, M; Li, Y; Sato, T	1
Decking, UK; Hartmann, M	1
Le Grand, B; Létienne, R; Vié, B	1
Clanachan, AS; Lopaschuk, GD; Wang, L	1

Reviews

3 review(s) available for r 56865 and piperidines

Article	Year
Inhibition of sodium and calcium overload pathology in the myocardium: a new cytoprotective principle. Cardiovascular research, 1993, Volume: 27, Issue:3 Topics: Benzothiazoles; Calcium; Calcium Channels; Heart; Heart Diseases; Humans; Myocardium; Piperidines; Potassium Channels; Sodium; Sodium Channels; Thiazoles	1993
Intracellular calcium modulators for cardiac muscle in pathological conditions. Japanese heart journal, 1996, Volume: 37, Issue:1 Topics: Animals; Anti-Arrhythmia Agents; Anticonvulsants; Arrhythmias, Cardiac; Benzothiazoles; Caffeine; Calcium; Calcium Channel Blockers; Dantrolene; Flunarizine; Homeostasis; Humans; Magnesium; Models, Cardiovascular; Muscle Relaxants, Central; Myocardial Contraction; Myocardium; Phenytoin; Piperidines; Ryanodine; Sarcoplasmic Reticulum; Thiazepines; Thiazoles	1996
Drugs preventing Na+ and Ca2+ overload. Pharmacological research, 1999, Volume: 39, Issue:3 Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzothiazoles; Calcium; Calcium Channel Blockers; Guanidines; Heart; Homeostasis; Humans; Piperidines; Sodium; Sodium Channel Blockers; Sodium Channels; Sodium-Hydrogen Exchangers; Sulfones; Thiazoles; Thiazolidines	1999

Trials

1 trial(s) available for r 56865 and piperidines

Article	Year
The negative inotropic and chronotropic effects of intravenous R 56865 during percutaneous transluminal coronary angioplasty. British journal of clinical pharmacology, 1995, Volume: 39, Issue:5 Topics: Angioplasty, Balloon, Coronary; Benzothiazoles; Blood Gas Analysis; Blood Pressure; Calcium Channel Blockers; Cardiac Output; Coronary Circulation; Coronary Disease; Female; Humans; Male; Myocardial Contraction; Piperidines; Thiazoles; Ventricular Function, Left	1995

Article

Year

The negative inotropic and chronotropic effects of intravenous R 56865 during percutaneous transluminal coronary angioplasty.

British journal of clinical pharmacology, 1995, Volume: 39, Issue:5

Topics: Angioplasty, Balloon, Coronary; Benzothiazoles; Blood Gas Analysis; Blood Pressure; Calcium Channel Blockers; Cardiac Output; Coronary Circulation; Coronary Disease; Female; Humans; Male; Myocardial Contraction; Piperidines; Thiazoles; Ventricular Function, Left

1995

Other Studies

66 other study(ies) available for r 56865 and piperidines

Article	Year
Effects of R 56865 and phenytoin on mechanical, biochemical, and morphologic changes during ouabain intoxication in isolated perfused rabbit heart. Journal of cardiovascular pharmacology, 1992, Volume: 20, Issue:3 Topics: Adenosine Triphosphate; Animals; Benzothiazoles; Blood Pressure; Calcium Channel Blockers; Chromatography, High Pressure Liquid; Heart; In Vitro Techniques; Lactates; Male; Mitochondria, Heart; Myocardial Contraction; Myocardium; Ouabain; Oxygen Consumption; Phenytoin; Phosphorylation; Piperidines; Rabbits; Thiazoles; Ventricular Function, Left	1992
Dependence of hypoxic cellular calcium loading on Na(+)-Ca2+ exchange. Circulation research, 1992, Volume: 71, Issue:3 Topics: Animals; Benzofurans; Benzothiazoles; Calcium; Cell Hypoxia; Ethers, Cyclic; Hydrogen-Ion Concentration; Indoles; Ischemia; Myocardium; Piperidines; Rats; Sodium; Sodium Channels; Sodium-Potassium-Exchanging ATPase; Thiazoles	1992
Veratridine activates a silent sodium channel in rat isolated aorta. European journal of pharmacology, 1992, Aug-25, Volume: 219, Issue:2 Topics: Amiloride; Animals; Aorta; Benzothiazoles; Calcium; Guanidine; Guanidines; In Vitro Techniques; Piperidines; Pyrroles; Rats; Sodium Channels; Tetrodotoxin; Thiazoles; Vasodilator Agents; Veratridine	1992
Differential effect of R 56865 on ouabain binding to isolated sarcolemma and intact atrial tissue of guinea-pig. British journal of pharmacology, 1991, Volume: 102, Issue:3 Topics: Animals; Benzothiazoles; Guinea Pigs; In Vitro Techniques; Myocardial Contraction; Myocardium; Ouabain; Piperidines; Sarcolemma; Sodium; Sodium-Potassium-Exchanging ATPase; Thiazoles	1991
Suppressive effects of R 56865 on triggered propagated contractions and triggered arrhythmias in rat cardiac trabeculae. Journal of cardiovascular pharmacology, 1992, Volume: 20, Issue:2 Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Benzothiazoles; Calcium; Calcium Channel Blockers; Electric Stimulation; Female; Gallopamil; Heart Ventricles; In Vitro Techniques; Male; Myocardial Contraction; Piperidines; Rats; Rats, Inbred Strains; Sarcoplasmic Reticulum; Thiazoles	1992
Effects of drugs on ventricular fibrillation and ischaemic K+ loss in a model of ischaemia in perfused guinea-pig hearts in vitro. European journal of pharmacology, 1992, Sep-22, Volume: 220, Issue:2-3 Topics: 4-Aminopyridine; Animals; Anti-Arrhythmia Agents; Benzothiazoles; Calcium Channel Blockers; Disease Models, Animal; Glipizide; Glyburide; Guinea Pigs; In Vitro Techniques; Male; Myocardial Ischemia; Piperidines; Potassium; Potassium Channels; Pyrazines; Pyridines; Sympatholytics; Thiazoles; Ventricular Fibrillation	1992
Lysophosphatidylcholine-induced Ca(2+)-overload in isolated cardiomyocytes and effect of cytoprotective drugs. Journal of molecular and cellular cardiology, 1992, Volume: 24, Issue:9 Topics: Animals; Benzothiazoles; Calcium; Flunarizine; Heart; Histocytochemistry; In Vitro Techniques; Intracellular Fluid; Ion Transport; Lysophosphatidylcholines; Microscopy, Electron; Myocardial Contraction; Myocardial Reperfusion Injury; Myocardium; Piperidines; Rabbits; Thiazoles	1992
Ouabain-induced changes of calcium and potassium in slices of hippocampus of the rat: comparison to hypoxia and effect of R 56865. Neuropharmacology, 1992, Volume: 31, Issue:5 Topics: Animals; Benzothiazoles; Brain Ischemia; Calcium; Disease Models, Animal; Hippocampus; Hypoxia, Brain; In Vitro Techniques; Male; Ouabain; Piperidines; Potassium; Rats; Rats, Inbred Strains; Thiazoles	1992
Sodium-dependent potassium (86Rb+) efflux moderates volume regulation by cells in rat renal inner medullary slices exposed to strongly hyperosmotic media. Biochemical and biophysical research communications, 1992, May-29, Volume: 185, Issue:1 Topics: Animals; Benzothiazoles; Biological Transport; In Vitro Techniques; Kidney Medulla; Male; Piperidines; Potassium; Potassium Channels; Rats; Rubidium Radioisotopes; Thiazoles; Water-Electrolyte Balance	1992
Flunarizine and R 56865 suppress veratridine-induced increase in oxygen consumption and uptake of 45Ca2+ in rat cortical synaptosomes. Neuropharmacology, 1992, Volume: 31, Issue:3 Topics: Animals; Benzothiazoles; Calcium; Calcium Radioisotopes; Cerebral Cortex; Flunarizine; In Vitro Techniques; Oxygen Consumption; Piperidines; Polarography; Rats; Synaptosomes; Tetrodotoxin; Thiazoles; Veratridine	1992
Pharmacological studies of arrhythmias induced by rose bengal photoactivation. Free radical biology & medicine, 1991, Volume: 10, Issue:5 Topics: Animals; Antioxidants; Arrhythmias, Cardiac; Benzothiazoles; Coronary Circulation; Electrocardiography; Free Radicals; Heart Rate; Male; Oxygen; Photolysis; Piperidines; Rats; Rats, Inbred Strains; Rose Bengal; Superoxides; Thiazoles	1991
Agonistic and antagonistic effect of R56865 on the Na+ channel in cardiac cells. European journal of pharmacology, 1991, Apr-10, Volume: 196, Issue:1 Topics: Animals; Benzothiazoles; Guinea Pigs; Heart; Membrane Potentials; Myocardium; Papillary Muscles; Piperidines; Purkinje Cells; Rabbits; Sodium; Sodium Channels; Thiazoles	1991
Myocardial protection by R 56865: a new principle based on prevention of ion channel pathology. The American journal of physiology, 1991, Volume: 261, Issue:6 Pt 2 Topics: Animals; Benzothiazoles; Calcium; Cardiomyopathies; Heart; Lysophosphatidylcholines; Myocardial Contraction; Ouabain; Oxygen; Piperidines; Rabbits; Rats; Singlet Oxygen; Sodium; Sodium Channels; Tetrodotoxin; Thiazoles; Veratridine	1991
Preferential block of the veratridine-induced, non-inactivating Na+ current by R56865 in single cardiac Purkinje cells. European journal of pharmacology, 1991, Oct-22, Volume: 203, Issue:3 Topics: Animals; Benzothiazoles; Heart; In Vitro Techniques; Membrane Potentials; Myocardium; Piperidines; Purkinje Cells; Rabbits; Sodium Channels; Tetrodotoxin; Thiazoles; Veratridine	1991
Veratridine-induced intoxication in the isolated left atrium of the rat: effects of some anti-ischemic compounds. Naunyn-Schmiedeberg's archives of pharmacology, 1991, Volume: 344, Issue:1 Topics: Animals; Atrial Function, Left; Benzothiazoles; Calcium; Coronary Disease; Dose-Response Relationship, Drug; Heart; In Vitro Techniques; Male; Piperidines; Pyrroles; Rats; Sodium; Sodium Channels; Thiazoles; Veratridine	1991
Characterization of the interaction of R 56865 with cardiac Na- and L-type Ca channels. British journal of pharmacology, 1991, Volume: 104, Issue:2 Topics: Action Potentials; Animals; Benzothiazoles; Biomechanical Phenomena; Calcium Channels; Guinea Pigs; Heart; In Vitro Techniques; Myocardium; Papillary Muscles; Piperidines; Sodium; Sodium Channels; Thiazoles; Veratridine	1991
Protective effects of R 56 865 against ischemic damage in the isolated rabbit heart. European journal of pharmacology, 1991, Sep-17, Volume: 202, Issue:2 Topics: Animals; Benzothiazoles; Calcium; Calcium Channels; Cell Death; Coronary Disease; Female; Hemodynamics; In Vitro Techniques; Male; Mitochondria, Heart; Myocardial Reperfusion Injury; Myocardium; Perfusion; Piperidines; Rabbits; Subcellular Fractions; Thiazoles; Verapamil	1991
R56865, a potent new antiarrhythmic agent, effective during ischemia and reperfusion in the rat heart. Journal of cardiovascular pharmacology, 1990, Volume: 16, Issue:3 Topics: Analysis of Variance; Animals; Arrhythmias, Cardiac; Benzothiazoles; Calcium; Coronary Disease; Hemodynamics; In Vitro Techniques; Male; Myocardial Reperfusion; Piperidines; Potassium; Rats; Rats, Inbred Strains; Thiazoles	1990
Effects of R56865 on membrane currents in isolated ventricular cardiomyocytes of the guinea-pig. European journal of pharmacology, 1990, Oct-09, Volume: 187, Issue:2 Topics: Animals; Benzothiazoles; Cadmium; Cesium; Guinea Pigs; Heart; In Vitro Techniques; Ion Channels; Membranes; Myocardium; Piperidines; Potassium Channels; Sodium Channels; Thiazoles	1990
Differential influence of various calcium-modulating compounds on ouabain intoxication in isolated rat left atria. Pharmacology, 1990, Volume: 41, Issue:6 Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Atrial Function; Atrial Function, Left; Benzothiazoles; Calcium; Calcium Channel Blockers; Cardiotonic Agents; Heart; Heart Atria; Intracellular Fluid; Male; Myocardial Contraction; Myocardium; Ouabain; Piperidines; Potassium; Rats; Rats, Inbred Strains; Sodium; Thiazoles	1990
Effects of R 56,865, a preventer of cellular calcium overload, on left ventricular diastolic properties during pacing-induced ischemia in dogs. Journal of cardiovascular pharmacology, 1991, Volume: 17, Issue:4 Topics: Animals; Benzothiazoles; Blood Pressure; Cardiac Pacing, Artificial; Coronary Disease; Coronary Vessels; Diastole; Dogs; Female; Heart Rate; Hemodynamics; Male; Piperidines; Propranolol; Thiazoles; Ventricular Function, Left	1991
Investigation of electrophysiologic mechanisms for the antiarrhythmic actions of R 56865 in cardiac glycoside toxicity. Journal of cardiovascular pharmacology, 1991, Volume: 18, Issue:3 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Atrioventricular Node; Benzothiazoles; Blood Pressure; Cardiac Glycosides; Dogs; Electrophysiology; Female; Guinea Pigs; Heart Conduction System; In Vitro Techniques; Male; Membrane Potentials; Microelectrodes; Ouabain; Papillary Muscles; Piperidines; Purkinje Fibers; Refractory Period, Electrophysiological; Thiazoles	1991
Block of the transient inward current by R56865 in guinea-pig ventricular myocytes. European journal of pharmacology, 1991, Apr-10, Volume: 196, Issue:1 Topics: Action Potentials; Animals; Benzothiazoles; Calcium; Cricetinae; Digitalis; Electrophysiology; Heart; Heart Ventricles; Membrane Potentials; Muscle, Smooth, Vascular; Myocardium; Piperidines; Plants, Medicinal; Plants, Toxic; Rabbits; Sodium; Thiazoles	1991
45Ca2+ movements induced by Ca2+ chloride in isolated rat aorta under K(+)-free conditions. European journal of pharmacology, 1991, Jan-17, Volume: 192, Issue:3 Topics: Amiloride; Animals; Aorta, Thoracic; Benzothiazoles; Calcium; Calcium Chloride; Calcium Radioisotopes; Flunarizine; In Vitro Techniques; Indomethacin; Lanthanum; Lidocaine; Nifedipine; omega-Conotoxins; Peptides, Cyclic; Piperidines; Potassium; Rats; Thiazoles; Vasoconstriction	1991
Na(+)-activated K+ current in cardiac cells: rectification, open probability, block and role in digitalis toxicity. Pflugers Archiv : European journal of physiology, 1990, Volume: 416, Issue:6 Topics: Animals; Benzothiazoles; Biological Transport; Carrier Proteins; Digitalis Glycosides; Electric Conductivity; Guinea Pigs; Heart; Myocardium; Piperidines; Potassium; Potassium Channels; Sodium; Sodium-Potassium-Chloride Symporters; Thiazoles	1990
A sodium-activated potassium current in intact ventricular myocytes isolated from the guinea-pig heart. Experimental physiology, 1990, Volume: 75, Issue:6 Topics: Action Potentials; Animals; Benzothiazoles; Calcium; Guinea Pigs; Heart; In Vitro Techniques; Magnesium; Piperidines; Potassium Channels; Sodium; Thiazoles	1990
R 56865 and flunarizine displace Ca2+ from phosphatidylserine monolayers in a stoichiometric manner. European journal of pharmacology, 1990, Jan-23, Volume: 188, Issue:1 Topics: Benzothiazoles; Binding, Competitive; Calcium; Calcium Radioisotopes; Flunarizine; Hydrogen-Ion Concentration; Membranes, Artificial; Phosphatidylserines; Piperidines; Thiazoles	1990
Phosphatidylserine monolayers as models for drug uptake into membranes and tissue. Cell biology international reports, 1990, Volume: 14, Issue:4 Topics: Animals; Aorta; Benzothiazoles; Cell Membrane; Diltiazem; Erythrocyte Membrane; Flunarizine; Heart Atria; Humans; Lidocaine; Membranes, Artificial; Models, Biological; Nitrendipine; Pharmaceutical Preparations; Pharmacokinetics; Phosphatidylserines; Piperidines; Rats; Thiazoles; Verapamil	1990
Class IV Ca2+ antagonists do not affect lipid peroxidation in singlet oxygen challenged cardiomyocytes. Cell biology international reports, 1990, Volume: 14, Issue:4 Topics: Animals; Benzothiazoles; Calcium Channel Blockers; Cell Separation; Cinnarizine; Diltiazem; Flunarizine; Lidoflazine; Lipid Peroxidation; Malondialdehyde; Myocardium; Nicardipine; Oxygen; Piperidines; Rats; Thiazoles; Verapamil	1990
R 56865 differentiates between contractile agents with respect to the nifedipine-sensitive component in the isolated rat aorta. Pharmacology, 1989, Volume: 39, Issue:1 Topics: Angiotensin II; Animals; Aorta, Thoracic; Arginine Vasopressin; Benzothiazoles; Calcium; Calcium Channels; Cytosol; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Piperidines; Rats; Rats, Inbred Strains; Serotonin; Thiazoles	1989
The protective action of R56865 against ouabain-induced intoxication in rat heart isolated atria and ventricles. European journal of pharmacology, 1989, May-30, Volume: 164, Issue:3 Topics: Animals; Benzothiazoles; Biological Transport, Active; Electric Stimulation; Erythrocytes; Heart; In Vitro Techniques; Male; Myocardial Contraction; Ouabain; Piperidines; Rats; Rats, Inbred Strains; Sodium; Thiazoles	1989
Different effects of R 56865 and calcium entry blockers on K+- and noradrenaline-induced contractions and 45Ca uptake in rat aorta. European journal of pharmacology, 1988, Dec-13, Volume: 158, Issue:3 Topics: Animals; Aorta; Benzothiazoles; Calcium; Calcium Channel Blockers; Diltiazem; Dose-Response Relationship, Drug; Flunarizine; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Norepinephrine; Piperidines; Potassium; Rats; Rats, Inbred Strains; Thiazoles; Verapamil	1988
R 56865 prevents electrical and mechanical signs of ouabain intoxication in guinea-pig papillary muscle. European journal of pharmacology, 1987, Oct-06, Volume: 142, Issue:1 Topics: Animals; Arrhythmias, Cardiac; Benzothiazoles; Calcium; Electrophysiology; Guinea Pigs; Heart; In Vitro Techniques; Ouabain; Papillary Muscles; Piperidines; Thiazoles	1987
Ion channel involvement in anoxic depolarization induced by cardiac arrest in rat brain. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1995, Volume: 15, Issue:4 Topics: Adenosine Triphosphate; Animals; Benzothiazoles; Calcium; Dizocilpine Maleate; Flunarizine; Glyburide; Heart Arrest; Hypoxia; Ion Channels; Male; Nimodipine; Piperidines; Potassium; Potassium Channels; Quinoxalines; Rats; Rats, Wistar; Sodium; Thiazoles	1995
Alleviation of contractile dysfunction in ischemic hearts by slowly inactivating Na+ current blockers. The American journal of physiology, 1995, Volume: 269, Issue:2 Pt 2 Topics: Action Potentials; Animals; Benzothiazoles; Biomechanical Phenomena; Electric Conductivity; Guinea Pigs; Heart; In Vitro Techniques; Male; Myocardial Contraction; Myocardial Ischemia; Myocardial Reperfusion; Papillary Muscles; Piperidines; Reference Values; Sodium; Tetrodotoxin; Thiazoles	1995
Cardioprotective drugs decrease the Na+ background current. Yonsei medical journal, 1995, Volume: 36, Issue:3 Topics: Amiloride; Animals; Benzothiazoles; Guinea Pigs; Heart; Heart Arrest, Induced; Myocardium; Piperidines; Potassium; Sodium; Thiazoles; Verapamil	1995
R 56 865, a Na+/Ca(2+)-overload inhibitor, protects against aconitine-induced cardiac arrhythmias in vivo. Journal of cardiovascular pharmacology, 1993, Volume: 22, Issue:1 Topics: Aconitine; Animals; Anti-Arrhythmia Agents; Benzothiazoles; Calcium; Dose-Response Relationship, Drug; Hemodynamics; Lidocaine; Male; Piperidines; Random Allocation; Rats; Rats, Wistar; Sodium; Sodium Channels; Tetrodotoxin; Thiazoles; Verapamil	1993
Effect of R56865 on cardiac sarcoplasmic reticulum function and its role as an antagonist of digoxin at the sarcoplasmic reticulum calcium release channel. British journal of pharmacology, 1995, Volume: 114, Issue:1 Topics: Adenosine Triphosphate; Animals; Benzothiazoles; Calcium; Calcium Channel Blockers; Calcium Channels; Digoxin; Dose-Response Relationship, Drug; Heart; Patch-Clamp Techniques; Piperidines; Sarcoplasmic Reticulum; Sheep; Thiazoles	1995
Attenuation by R 56865, a novel cytoprotective drug, of regional myocardial ischemia- and reperfusion-induced electrocardiographic disturbances in anesthetized rabbits. Journal of cardiovascular pharmacology, 1995, Volume: 25, Issue:1 Topics: Analysis of Variance; Animals; Arrhythmias, Cardiac; Benzothiazoles; Calcium Channel Blockers; Disease Models, Animal; Dose-Response Relationship, Drug; Electrocardiography; Heart; Hemodynamics; Injections, Intravenous; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Piperidines; Rabbits; Random Allocation; Thiazoles	1995
Effects of R56865, an Na(+)- and Ca(2+)-overload inhibitor, on myocardial injury in ischemic, reperfused porcine hearts. Journal of cardiovascular pharmacology, 1995, Volume: 25, Issue:1 Topics: Animals; Benzothiazoles; Blood Pressure; Calcium; Calcium Channel Blockers; Coronary Circulation; Female; Heart Rate; Injections, Intravenous; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Oxygen Consumption; Piperidines; Sodium; Sodium Channel Blockers; Swine; Thiazoles; Ventricular Fibrillation	1995
Effects of R 56865 on postischemic ventricular function in isolated rat working heart preparations obtained from healthy, diabetic and hypertensive animals. Naunyn-Schmiedeberg's archives of pharmacology, 1994, Volume: 349, Issue:6 Topics: Animals; Benzothiazoles; Blood Glucose; Blood Pressure; Body Weight; Calcium Channel Blockers; Cardiac Output; Coronary Circulation; Diabetes Mellitus, Experimental; Heart; Heart Ventricles; Hypertension; In Vitro Techniques; Male; Myocardial Ischemia; Piperidines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Wistar; Thiazoles; Ventricular Function; Ventricular Pressure	1994
Effects of substrate-free anoxia and veratridine on intracellular calcium concentration in isolated rat ventricular cardiomyocytes. Pflugers Archiv : European journal of physiology, 1994, Volume: 428, Issue:2 Topics: Animals; Benzothiazoles; Calcium; Calcium Channel Blockers; Cell Hypoxia; Cell Separation; Cell Size; Male; Microscopy, Fluorescence; Myocardial Contraction; Myocardium; Piperidines; Rats; Rats, Wistar; Sodium; Thiazoles; Veratridine	1994
Sodium channel blockade reduces hypoxic sodium loading and sodium-dependent calcium loading. Circulation, 1994, Volume: 90, Issue:1 Topics: Amiloride; Animals; Benzofurans; Benzothiazoles; Calcium; Calcium Channel Blockers; Cell Separation; Ethers, Cyclic; Fluorescent Dyes; Hypoxia; Lidocaine; Myocardial Contraction; Myocardium; Piperidines; Rats; Sodium; Sodium Channel Blockers; Sodium-Hydrogen Exchangers; Tetrodotoxin; Thiazoles	1994
Effects of R-56865 on transient inward current, Na(+)-Ca2+ exchange, and Ca2+ release from SR in cardiac myocytes. The American journal of physiology, 1994, Volume: 266, Issue:2 Pt 2 Topics: Animals; Benzothiazoles; Calcium; Calcium Channel Blockers; Carrier Proteins; Cells, Cultured; Guinea Pigs; Heart; Kinetics; Membrane Potentials; Myocardium; Piperidines; Sarcoplasmic Reticulum; Sodium; Sodium-Calcium Exchanger; Thiazoles; Time Factors	1994
R56865, a Na(+)- and Ca(2+)-overload inhibitor, reduces myocardial ischemia-reperfusion injury in blood-perfused rabbit hearts. Journal of molecular and cellular cardiology, 1993, Volume: 25, Issue:12 Topics: Animals; Benzothiazoles; Blood; Calcium; Energy Metabolism; Heart; Myocardial Reperfusion Injury; Myocardium; Perfusion; Piperidines; Rabbits; Sodium; Thiazoles; Ventricular Function, Left	1993
R56865, an antiarrhythmic drug with class III effects that terminates ouabain induced ventricular tachycardia in an inverse rate dependent manner. Cardiovascular research, 1993, Volume: 27, Issue:8 Topics: Animals; Anti-Arrhythmia Agents; Benzothiazoles; Dogs; Dose-Response Relationship, Drug; Female; Heart Rate; Hemodynamics; Male; Ouabain; Piperidines; Tachycardia; Thiazoles	1993
R 56865 delays cellular electrical uncoupling in ischemic rabbit papillary muscle. Journal of molecular and cellular cardiology, 1993, Volume: 25, Issue:9 Topics: Action Potentials; Animals; Benzothiazoles; Calcium; Heart Conduction System; In Vitro Techniques; Myocardial Contraction; Myocardial Ischemia; Piperidines; Rabbits; Thiazoles	1993
Interference of N-(1-[4-(4-fluorophenoxy)butyl]-piperidinyl)-N-methyl- 2-benzothiazolamine with Na+/H+ exchange and Na+/Ca2+ exchange in purified cardiac sarcolemmal membranes. Arzneimittel-Forschung, 1993, Volume: 43, Issue:11 Topics: Amiloride; Animals; Benzothiazoles; Calcium; Cattle; Heart; Hydrogen; In Vitro Techniques; Ion Exchange; Membranes; Myocardial Reperfusion; Myocardium; Ouabain; Piperidines; Sarcolemma; Sodium; Thiazoles	1993
R56865 inhibits catecholamine release from bovine chromaffin cells by blocking calcium channels. British journal of pharmacology, 1993, Volume: 110, Issue:3 Topics: Animals; Benzothiazoles; Calcium; Calcium Channel Blockers; Calcium Channels; Catecholamines; Cattle; Chromaffin System; Cytosol; Electroporation; Homeostasis; Piperidines; Potassium; Thiazoles	1993
R56865 as Ca(2+)-channel blocker in Purkinje neurons of rat: comparison with flunarizine and nimodipine. Neuroscience, 1993, Volume: 54, Issue:3 Topics: Animals; Benzothiazoles; Calcium Channel Blockers; Electrophysiology; Evoked Potentials; Flunarizine; In Vitro Techniques; Nimodipine; Piperidines; Purkinje Cells; Rats; Rats, Wistar; Thiazoles	1993
R56865 and flunarizine as Na(+)-channel blockers in isolated Purkinje neurons of rat cerebellum. Neuroscience, 1993, Volume: 54, Issue:3 Topics: Animals; Benzothiazoles; Calcium Channel Blockers; Cerebellum; Electric Stimulation; Electrophysiology; Flunarizine; In Vitro Techniques; Piperidines; Purkinje Cells; Rats; Rats, Wistar; Sodium Channels; Tetrodotoxin; Thiazoles	1993
Inhibition of Na+/Ca2+ overload with R 56,865 protects against cardiac arrhythmias elicited by ouabain in vivo in guinea-pigs. European journal of pharmacology, 1993, Apr-22, Volume: 235, Issue:1 Topics: Animals; Arrhythmias, Cardiac; Benzothiazoles; Blood Pressure; Calcium; Electrocardiography; Guinea Pigs; Heart Rate; Lidocaine; Male; Ouabain; Piperidines; Sodium; Tetrodotoxin; Thiazoles; Verapamil	1993
R56865 is antifibrillatory in reperfused ischemic guinea-pig hearts, even when given only during reperfusion. Cardiovascular drugs and therapy, 1995, Volume: 9, Issue:4 Topics: Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Benzothiazoles; Calcium; Calcium Channel Blockers; Extracellular Space; Guinea Pigs; Heart; In Vitro Techniques; Lidocaine; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Piperidines; Potassium; Sodium; Thiazoles; Verapamil	1995
Nature of the cardiomyocyte injury induced by lipid hydroperoxides. Cardiovascular research, 1995, Volume: 30, Issue:5 Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Action Potentials; Amlodipine; Animals; Benzothiazoles; Calcium; Calcium Channel Blockers; Cells, Cultured; Dose-Response Relationship, Drug; Free Radical Scavengers; Free Radicals; Guinea Pigs; L-Lactate Dehydrogenase; Leukotrienes; Lipid Peroxides; Membrane Potentials; Myocardium; Necrosis; Piperidines; Rats; Rats, Wistar; Respiratory Burst; Ryanodine; Thiazoles; Vasoconstrictor Agents	1995
In vivo effects of a novel calcium antagonist (R56865) against induced epoxyscillirosidin and tulp poisoning in sheep. The Onderstepoort journal of veterinary research, 1995, Volume: 62, Issue:3 Topics: Animals; Benzothiazoles; Bufanolides; Calcium Channel Blockers; Cholenes; In Vitro Techniques; Piperidines; Plant Extracts; Plant Poisoning; Sheep; Sheep Diseases; Thiazoles; Toxins, Biological	1995
The actions of ouabain and lithium chloride on cytosolic Ca2+ in single chromaffin cells. European journal of pharmacology, 1996, Jun-13, Volume: 306, Issue:1-3 Topics: Adrenal Glands; Animals; Antimanic Agents; Benzothiazoles; Calcium; Calcium Channel Blockers; Calcium Channels; Cattle; Cell Membrane; Cells, Cultured; Chromaffin System; Enzyme Inhibitors; Lithium Chloride; omega-Conotoxins; Ouabain; Peptides; Piperidines; Sodium; Sodium-Potassium-Exchanging ATPase; Thiazoles; Veratridine	1996
The protective effects of CP-060S on ischaemia- and reperfusion- induced arrhythmias in anaesthetized rats. British journal of pharmacology, 1998, Volume: 123, Issue:7 Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzothiazoles; Calcium Channel Blockers; Diltiazem; Hemodynamics; Male; Myocardial Ischemia; Myocardial Reperfusion; Piperidines; Rats; Rats, Sprague-Dawley; Thiazoles; Thiazolidines	1998
Late sodium current inhibition in human isolated cardiomyocytes by R 56865. Journal of cardiovascular pharmacology, 1998, Volume: 31, Issue:5 Topics: Benzothiazoles; Calcium Channel Blockers; Dose-Response Relationship, Drug; Heart Atria; Humans; Patch-Clamp Techniques; Piperidines; Sodium Channel Blockers; Sodium Channels; Thiazoles	1998
Ischemia/reperfusion-induced arrhythmias in anaesthetized rats: a role of Na+ and Ca2+ influx. European journal of pharmacology, 1999, Jan-22, Volume: 365, Issue:2-3 Topics: Amiloride; Anesthesia; Animals; Arrhythmias, Cardiac; Benzothiazoles; Blood Pressure; Calcium; Calcium Channel Blockers; Calcium Channels; Heart Rate; Lidocaine; Male; Myocardial Reperfusion Injury; Piperidines; Rats; Rats, Wistar; Sodium; Sodium Channel Blockers; Sodium Channels; Thiazoles; Verapamil	1999
The anti-ischemic effects of CP-060S during pacing-induced ischemia in anesthetized dogs. European journal of pharmacology, 1999, Feb-19, Volume: 367, Issue:2-3 Topics: Anesthesia; Animals; Benzothiazoles; Calcium Channel Blockers; Coronary Vessels; Diltiazem; Dogs; Drug Synergism; Electrocardiography; Ischemia; Male; Piperidines; Thiazoles; Thiazolidines	1999
A Na+-activated K+ current (IK,Na) is present in guinea-pig but not rat ventricular myocytes. Pflugers Archiv : European journal of physiology, 1999, Volume: 437, Issue:6 Topics: Animals; Benzothiazoles; Calcium; Calcium Channel Blockers; Diltiazem; Electric Conductivity; Glyburide; Guinea Pigs; Heart; Magnesium; Male; Membrane Potentials; Patch-Clamp Techniques; Piperidines; Potassium; Potassium Channels; Rats; Rats, Sprague-Dawley; Sodium; Sodium-Potassium-Exchanging ATPase; Thiazoles; Ventricular Function	1999
Electrophysiological actions of N-[1-[4-(4-fluorophenoxy)butyl]-4-piperidinyl]-N-methyl-2-benzothiazola mine (R56865) on CA1 neurons of the rat hippocampal slice during hypoxia. Neuroscience letters, 1999, Aug-06, Volume: 270, Issue:3 Topics: Animals; Benzothiazoles; Calcium Channel Blockers; Electric Stimulation; Electrophysiology; Hippocampus; Hypoxia; In Vitro Techniques; Neurons; Piperidines; Rats; Reference Values; Synaptic Transmission; Thiazoles	1999
Bepridil blunts the shortening of action potential duration caused by metabolic inhibition via blockade of ATP-sensitive K(+) channels and Na(+)-activated K(+) channels. The Journal of pharmacology and experimental therapeutics, 1999, Volume: 291, Issue:2 Topics: Action Potentials; Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Benzothiazoles; Bepridil; Calcium Channel Blockers; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Dose-Response Relationship, Drug; Glyburide; Guinea Pigs; Heart Ventricles; In Vitro Techniques; Patch-Clamp Techniques; Perfusion; Piperidines; Potassium Channels; Sodium; Thiazoles; Time Factors; Uncoupling Agents	1999
R 56865 exerts cardioprotective properties independent of the intracellular Na(+)-overload in the guinea pig heart. Naunyn-Schmiedeberg's archives of pharmacology, 2003, Volume: 368, Issue:3 Topics: Animals; Benzothiazoles; Cardiotonic Agents; Energy Metabolism; Guinea Pigs; Hydrogen-Ion Concentration; In Vitro Techniques; Intracellular Space; Magnetic Resonance Spectroscopy; Myocardial Contraction; Myocardium; Myocytes, Cardiac; Piperidines; Sodium; Thiazoles; Time Factors	2003
Pharmacological characterisation of sodium channels in sinoatrial node pacemaking in the rat heart. European journal of pharmacology, 2006, Jan-20, Volume: 530, Issue:3 Topics: Animals; Benzothiazoles; Bradycardia; Heart Atria; Heart Rate; Lidocaine; Male; Piperidines; Rats; Rats, Sprague-Dawley; Sinoatrial Node; Sodium Channel Blockers; Sodium Channels; Tetrodotoxin; Thiadiazoles; Thiazoles	2006
H(2)O(2)-induced left ventricular dysfunction in isolated working rat hearts is independent of calcium accumulation. Journal of molecular and cellular cardiology, 2008, Volume: 45, Issue:6 Topics: Animals; Anti-Arrhythmia Agents; Benzothiazoles; Calcium; Calcium Channel Blockers; Cardiotonic Agents; Cnidarian Venoms; Hydrogen Peroxide; Ion Transport; Lidocaine; Male; Myocardial Reperfusion Injury; Myocardium; Organ Culture Techniques; Ouabain; Oxidants; Piperidines; Rats; Rats, Sprague-Dawley; Ventricular Dysfunction, Left	2008

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