r 56865 has been researched along with piperidines in 70 studies
Studies (r 56865) | Trials (r 56865) | Recent Studies (post-2010) (r 56865) | Studies (piperidines) | Trials (piperidines) | Recent Studies (post-2010) (piperidines) |
---|---|---|---|---|---|
72 | 1 | 0 | 40,235 | 5,221 | 14,545 |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 4 (5.71) | 18.7374 |
1990's | 63 (90.00) | 18.2507 |
2000's | 3 (4.29) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Frankow, C; Peters, T; Tegtmeier, F; Thoné, F; Vandeplassche, L; Wilhelm, D | 1 |
Haigney, MC; Lakatta, EG; Miyata, H; Silverman, HS; Stern, MD | 1 |
Leidig, A; Nebel, U; Peters, T; Wermelskirchen, D; Wilffert, B; Wirth, A | 1 |
Heers, C; Peters, T; Scheufler, E; Wermelskirchen, D; Wilffert, B; Wilhelm, D | 1 |
Daniels, MC; ter Keurs, HE | 1 |
Gwilt, M; Henderson, CG; Orme, J; Rourke, JD | 1 |
Borgers, M; Geerts, H; Ver Donck, L; Verellen, G | 1 |
Beile, A; Guttmann, I; Osikowska-Evers, B; Peters, T; Scheufler, E; Tegtmeier, F; Urenjak, J; Wilffert, B | 1 |
Law, RO | 1 |
Gleitz, J; Peters, T; Tegtmeier, F; Urenjak, J; Wermelskirchen, D; Wilffert, B | 1 |
Bernier, M; Borgers, M; Hearse, DJ; Kusama, Y; Neckers, DC; Valdes-Aguilera, O; Ver Donck, L | 1 |
Carmeliet, E; Tytgat, J | 1 |
Borgers, M; Ver Donck, L | 1 |
Bielen, FV; Ver Donck, L; Verdonck, F | 1 |
Nebel, U; Peters, T; Wermelskirchen, D; Wilffert, B; Wirth, A | 1 |
Himmel, H; Peters, T; Ravens, U; Wilhelm, D | 1 |
Borgers, M; Thoné, F; Vandeplassche, G | 1 |
Bernier, M; Garner, JA; Hearse, DJ | 1 |
Himmel, HM; Ravens, U; Wilhelm, D | 1 |
Peters, T; Scheufler, E; Wilhelm, D | 1 |
Borgers, M; Hermans, C; Vandeplassche, G; Wouters, L | 1 |
Damiano, BP; Stump, GL; Yagel, SK | 1 |
Carmeliet, E; Leyssens, A | 1 |
Nebel, U; Wermelskirchen, D; Wilffert, B; Wirth, A | 1 |
Carmeliet, E; Luk, HN | 1 |
Chapman, RA; Rodrigo, GC | 1 |
Scheufler, E; Vogelgesang, R | 1 |
Peters, T; Scheufler, E | 1 |
Borgers, M; De Clerck, F; Vandewiele, R; Ver Donck, L; Verellen, G | 1 |
Koch, P; Peters, T; Wilffert, B; Wilhelm, D | 1 |
Bravo, G; Finet, M; Godfraind, T | 1 |
Koch, P; Nebel, U; Peters, T; Wermelskirchen, D; Wilffert, B; Wilhelm, D | 1 |
Janssen, PA; Meuter, C; Vollmer, B | 1 |
Hoff, P; Tegtmeier, F; Xie, Y; Zacharias, E | 1 |
Coraboeuf, E; John, GW; Le Grand, B; Talmant, JM; Vie, B | 1 |
Park, SR; Ryu, GH; Suh, CK | 1 |
David, GK; Koch, K; Koolen, JJ; Piek, JJ; Pijl, AJ; Swaan, A; Van Wezel, HB; Van Zwieten, PA; Visser, CA | 1 |
De Clerck, F; Lu, HR | 1 |
McGarry, SJ; Scheufler, E; Williams, AJ | 1 |
De Courtois, F; John, GW; Le Grand, B; Pouget, G; Verscheure, Y | 1 |
Klein, HH; Lindert-Heimberg, S; Maisch, B; Nebendahl, K; Pich, S | 1 |
Hendriks, MG; Kam, KL; Paffendorf, M; Pijl, AJ; van Zwieten, PA | 1 |
Bindels, RJ; Couwenberg, P; Jansen, JW; Rose, UM; Van Os, CH | 1 |
Haigney, MC; Lakatta, EG; Silverman, HS; Stern, MD | 1 |
Coetzee, WA; Hearse, DJ; Ichikawa, H | 1 |
Borgers, M; Chen, CC; Flameng, W; Lin, W; Masuda, M; Morishige, N; Mubagwa, K; Thoné, F; Wieland, W | 1 |
Gorgels, AP; Leunissen, JD; van Deursen, RT; Vos, MA; Wellens, HJ | 1 |
Coronel, R; Janse, MJ; Mazón, P; Netea, AO; Opthof, T; Sleeswijk, ME; Tan, HL | 1 |
Heers, C; Peters, T; Pierce, GN; Scheufler, E; Wilffert, B | 1 |
Albillos, A; Artalejo, AR; de la Fuente, MT; Gandía, L; Garcez-Do-Carmo, L; García, AG; López, MG; Michelena, P | 1 |
Krishtal, OA; Panchenko, VA; Tegtmeier, F | 1 |
Borgers, M; Ver Donck, L; Verdonck, F | 1 |
Chizhmakov, IV; Kiskin, NI; Krishtal, OA; Tegtmeier, F | 1 |
De Clerck, F; Lu, HR; Remeysen, P | 1 |
Guttmann, I; Mozes, A; Scheufler, E; Wilffert, B | 1 |
Cambarrat, C; Iliou, JP; Robin, F; Thollon, C; Vilaine, JP | 1 |
Kellerman, TS; Maartens, BP; Mülders, MS; Schultz, RA; Swan, GE; Van der Walt, JJ | 1 |
Ishide, N | 1 |
De la Fuente, MT; Esquerro, E; García, AG; Maroto, R; Sánchez-García, P | 1 |
Adachi, Y; Akima, M; Fukazawa, M; Kato, T; Koga, T; Kuromaru, O; Suzuki, Y; Tamura, K | 1 |
Coulombe, A; John, GW; Le Grand, B | 1 |
Dai, DZ; De Clerck, F; Lu, HR; Remeysen, P; Saels, A; Yang, P | 1 |
Adachi, Y; Fukazawa, M; Homma, N; Kuromaru, O; Nishie, I; Suzuki, Y; Tamura, K | 1 |
Himmel, HM; Ravens, U | 1 |
Lawrence, C; Rodrigo, GC | 1 |
Barbieri, M; Nistri, A | 1 |
Arita, M; Li, Y; Sato, T | 1 |
Decking, UK; Hartmann, M | 1 |
Le Grand, B; Létienne, R; Vié, B | 1 |
Clanachan, AS; Lopaschuk, GD; Wang, L | 1 |
3 review(s) available for r 56865 and piperidines
Article | Year |
---|---|
Inhibition of sodium and calcium overload pathology in the myocardium: a new cytoprotective principle.
Topics: Benzothiazoles; Calcium; Calcium Channels; Heart; Heart Diseases; Humans; Myocardium; Piperidines; Potassium Channels; Sodium; Sodium Channels; Thiazoles | 1993 |
Intracellular calcium modulators for cardiac muscle in pathological conditions.
Topics: Animals; Anti-Arrhythmia Agents; Anticonvulsants; Arrhythmias, Cardiac; Benzothiazoles; Caffeine; Calcium; Calcium Channel Blockers; Dantrolene; Flunarizine; Homeostasis; Humans; Magnesium; Models, Cardiovascular; Muscle Relaxants, Central; Myocardial Contraction; Myocardium; Phenytoin; Piperidines; Ryanodine; Sarcoplasmic Reticulum; Thiazepines; Thiazoles | 1996 |
Drugs preventing Na+ and Ca2+ overload.
Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzothiazoles; Calcium; Calcium Channel Blockers; Guanidines; Heart; Homeostasis; Humans; Piperidines; Sodium; Sodium Channel Blockers; Sodium Channels; Sodium-Hydrogen Exchangers; Sulfones; Thiazoles; Thiazolidines | 1999 |
1 trial(s) available for r 56865 and piperidines
Article | Year |
---|---|
The negative inotropic and chronotropic effects of intravenous R 56865 during percutaneous transluminal coronary angioplasty.
Topics: Angioplasty, Balloon, Coronary; Benzothiazoles; Blood Gas Analysis; Blood Pressure; Calcium Channel Blockers; Cardiac Output; Coronary Circulation; Coronary Disease; Female; Humans; Male; Myocardial Contraction; Piperidines; Thiazoles; Ventricular Function, Left | 1995 |
66 other study(ies) available for r 56865 and piperidines
Article | Year |
---|---|
Effects of R 56865 and phenytoin on mechanical, biochemical, and morphologic changes during ouabain intoxication in isolated perfused rabbit heart.
Topics: Adenosine Triphosphate; Animals; Benzothiazoles; Blood Pressure; Calcium Channel Blockers; Chromatography, High Pressure Liquid; Heart; In Vitro Techniques; Lactates; Male; Mitochondria, Heart; Myocardial Contraction; Myocardium; Ouabain; Oxygen Consumption; Phenytoin; Phosphorylation; Piperidines; Rabbits; Thiazoles; Ventricular Function, Left | 1992 |
Dependence of hypoxic cellular calcium loading on Na(+)-Ca2+ exchange.
Topics: Animals; Benzofurans; Benzothiazoles; Calcium; Cell Hypoxia; Ethers, Cyclic; Hydrogen-Ion Concentration; Indoles; Ischemia; Myocardium; Piperidines; Rats; Sodium; Sodium Channels; Sodium-Potassium-Exchanging ATPase; Thiazoles | 1992 |
Veratridine activates a silent sodium channel in rat isolated aorta.
Topics: Amiloride; Animals; Aorta; Benzothiazoles; Calcium; Guanidine; Guanidines; In Vitro Techniques; Piperidines; Pyrroles; Rats; Sodium Channels; Tetrodotoxin; Thiazoles; Vasodilator Agents; Veratridine | 1992 |
Differential effect of R 56865 on ouabain binding to isolated sarcolemma and intact atrial tissue of guinea-pig.
Topics: Animals; Benzothiazoles; Guinea Pigs; In Vitro Techniques; Myocardial Contraction; Myocardium; Ouabain; Piperidines; Sarcolemma; Sodium; Sodium-Potassium-Exchanging ATPase; Thiazoles | 1991 |
Suppressive effects of R 56865 on triggered propagated contractions and triggered arrhythmias in rat cardiac trabeculae.
Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Benzothiazoles; Calcium; Calcium Channel Blockers; Electric Stimulation; Female; Gallopamil; Heart Ventricles; In Vitro Techniques; Male; Myocardial Contraction; Piperidines; Rats; Rats, Inbred Strains; Sarcoplasmic Reticulum; Thiazoles | 1992 |
Effects of drugs on ventricular fibrillation and ischaemic K+ loss in a model of ischaemia in perfused guinea-pig hearts in vitro.
Topics: 4-Aminopyridine; Animals; Anti-Arrhythmia Agents; Benzothiazoles; Calcium Channel Blockers; Disease Models, Animal; Glipizide; Glyburide; Guinea Pigs; In Vitro Techniques; Male; Myocardial Ischemia; Piperidines; Potassium; Potassium Channels; Pyrazines; Pyridines; Sympatholytics; Thiazoles; Ventricular Fibrillation | 1992 |
Lysophosphatidylcholine-induced Ca(2+)-overload in isolated cardiomyocytes and effect of cytoprotective drugs.
Topics: Animals; Benzothiazoles; Calcium; Flunarizine; Heart; Histocytochemistry; In Vitro Techniques; Intracellular Fluid; Ion Transport; Lysophosphatidylcholines; Microscopy, Electron; Myocardial Contraction; Myocardial Reperfusion Injury; Myocardium; Piperidines; Rabbits; Thiazoles | 1992 |
Ouabain-induced changes of calcium and potassium in slices of hippocampus of the rat: comparison to hypoxia and effect of R 56865.
Topics: Animals; Benzothiazoles; Brain Ischemia; Calcium; Disease Models, Animal; Hippocampus; Hypoxia, Brain; In Vitro Techniques; Male; Ouabain; Piperidines; Potassium; Rats; Rats, Inbred Strains; Thiazoles | 1992 |
Sodium-dependent potassium (86Rb+) efflux moderates volume regulation by cells in rat renal inner medullary slices exposed to strongly hyperosmotic media.
Topics: Animals; Benzothiazoles; Biological Transport; In Vitro Techniques; Kidney Medulla; Male; Piperidines; Potassium; Potassium Channels; Rats; Rubidium Radioisotopes; Thiazoles; Water-Electrolyte Balance | 1992 |
Flunarizine and R 56865 suppress veratridine-induced increase in oxygen consumption and uptake of 45Ca2+ in rat cortical synaptosomes.
Topics: Animals; Benzothiazoles; Calcium; Calcium Radioisotopes; Cerebral Cortex; Flunarizine; In Vitro Techniques; Oxygen Consumption; Piperidines; Polarography; Rats; Synaptosomes; Tetrodotoxin; Thiazoles; Veratridine | 1992 |
Pharmacological studies of arrhythmias induced by rose bengal photoactivation.
Topics: Animals; Antioxidants; Arrhythmias, Cardiac; Benzothiazoles; Coronary Circulation; Electrocardiography; Free Radicals; Heart Rate; Male; Oxygen; Photolysis; Piperidines; Rats; Rats, Inbred Strains; Rose Bengal; Superoxides; Thiazoles | 1991 |
Agonistic and antagonistic effect of R56865 on the Na+ channel in cardiac cells.
Topics: Animals; Benzothiazoles; Guinea Pigs; Heart; Membrane Potentials; Myocardium; Papillary Muscles; Piperidines; Purkinje Cells; Rabbits; Sodium; Sodium Channels; Thiazoles | 1991 |
Myocardial protection by R 56865: a new principle based on prevention of ion channel pathology.
Topics: Animals; Benzothiazoles; Calcium; Cardiomyopathies; Heart; Lysophosphatidylcholines; Myocardial Contraction; Ouabain; Oxygen; Piperidines; Rabbits; Rats; Singlet Oxygen; Sodium; Sodium Channels; Tetrodotoxin; Thiazoles; Veratridine | 1991 |
Preferential block of the veratridine-induced, non-inactivating Na+ current by R56865 in single cardiac Purkinje cells.
Topics: Animals; Benzothiazoles; Heart; In Vitro Techniques; Membrane Potentials; Myocardium; Piperidines; Purkinje Cells; Rabbits; Sodium Channels; Tetrodotoxin; Thiazoles; Veratridine | 1991 |
Veratridine-induced intoxication in the isolated left atrium of the rat: effects of some anti-ischemic compounds.
Topics: Animals; Atrial Function, Left; Benzothiazoles; Calcium; Coronary Disease; Dose-Response Relationship, Drug; Heart; In Vitro Techniques; Male; Piperidines; Pyrroles; Rats; Sodium; Sodium Channels; Thiazoles; Veratridine | 1991 |
Characterization of the interaction of R 56865 with cardiac Na- and L-type Ca channels.
Topics: Action Potentials; Animals; Benzothiazoles; Biomechanical Phenomena; Calcium Channels; Guinea Pigs; Heart; In Vitro Techniques; Myocardium; Papillary Muscles; Piperidines; Sodium; Sodium Channels; Thiazoles; Veratridine | 1991 |
Protective effects of R 56 865 against ischemic damage in the isolated rabbit heart.
Topics: Animals; Benzothiazoles; Calcium; Calcium Channels; Cell Death; Coronary Disease; Female; Hemodynamics; In Vitro Techniques; Male; Mitochondria, Heart; Myocardial Reperfusion Injury; Myocardium; Perfusion; Piperidines; Rabbits; Subcellular Fractions; Thiazoles; Verapamil | 1991 |
R56865, a potent new antiarrhythmic agent, effective during ischemia and reperfusion in the rat heart.
Topics: Analysis of Variance; Animals; Arrhythmias, Cardiac; Benzothiazoles; Calcium; Coronary Disease; Hemodynamics; In Vitro Techniques; Male; Myocardial Reperfusion; Piperidines; Potassium; Rats; Rats, Inbred Strains; Thiazoles | 1990 |
Effects of R56865 on membrane currents in isolated ventricular cardiomyocytes of the guinea-pig.
Topics: Animals; Benzothiazoles; Cadmium; Cesium; Guinea Pigs; Heart; In Vitro Techniques; Ion Channels; Membranes; Myocardium; Piperidines; Potassium Channels; Sodium Channels; Thiazoles | 1990 |
Differential influence of various calcium-modulating compounds on ouabain intoxication in isolated rat left atria.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Atrial Function; Atrial Function, Left; Benzothiazoles; Calcium; Calcium Channel Blockers; Cardiotonic Agents; Heart; Heart Atria; Intracellular Fluid; Male; Myocardial Contraction; Myocardium; Ouabain; Piperidines; Potassium; Rats; Rats, Inbred Strains; Sodium; Thiazoles | 1990 |
Effects of R 56,865, a preventer of cellular calcium overload, on left ventricular diastolic properties during pacing-induced ischemia in dogs.
Topics: Animals; Benzothiazoles; Blood Pressure; Cardiac Pacing, Artificial; Coronary Disease; Coronary Vessels; Diastole; Dogs; Female; Heart Rate; Hemodynamics; Male; Piperidines; Propranolol; Thiazoles; Ventricular Function, Left | 1991 |
Investigation of electrophysiologic mechanisms for the antiarrhythmic actions of R 56865 in cardiac glycoside toxicity.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Atrioventricular Node; Benzothiazoles; Blood Pressure; Cardiac Glycosides; Dogs; Electrophysiology; Female; Guinea Pigs; Heart Conduction System; In Vitro Techniques; Male; Membrane Potentials; Microelectrodes; Ouabain; Papillary Muscles; Piperidines; Purkinje Fibers; Refractory Period, Electrophysiological; Thiazoles | 1991 |
Block of the transient inward current by R56865 in guinea-pig ventricular myocytes.
Topics: Action Potentials; Animals; Benzothiazoles; Calcium; Cricetinae; Digitalis; Electrophysiology; Heart; Heart Ventricles; Membrane Potentials; Muscle, Smooth, Vascular; Myocardium; Piperidines; Plants, Medicinal; Plants, Toxic; Rabbits; Sodium; Thiazoles | 1991 |
45Ca2+ movements induced by Ca2+ chloride in isolated rat aorta under K(+)-free conditions.
Topics: Amiloride; Animals; Aorta, Thoracic; Benzothiazoles; Calcium; Calcium Chloride; Calcium Radioisotopes; Flunarizine; In Vitro Techniques; Indomethacin; Lanthanum; Lidocaine; Nifedipine; omega-Conotoxins; Peptides, Cyclic; Piperidines; Potassium; Rats; Thiazoles; Vasoconstriction | 1991 |
Na(+)-activated K+ current in cardiac cells: rectification, open probability, block and role in digitalis toxicity.
Topics: Animals; Benzothiazoles; Biological Transport; Carrier Proteins; Digitalis Glycosides; Electric Conductivity; Guinea Pigs; Heart; Myocardium; Piperidines; Potassium; Potassium Channels; Sodium; Sodium-Potassium-Chloride Symporters; Thiazoles | 1990 |
A sodium-activated potassium current in intact ventricular myocytes isolated from the guinea-pig heart.
Topics: Action Potentials; Animals; Benzothiazoles; Calcium; Guinea Pigs; Heart; In Vitro Techniques; Magnesium; Piperidines; Potassium Channels; Sodium; Thiazoles | 1990 |
R 56865 and flunarizine displace Ca2+ from phosphatidylserine monolayers in a stoichiometric manner.
Topics: Benzothiazoles; Binding, Competitive; Calcium; Calcium Radioisotopes; Flunarizine; Hydrogen-Ion Concentration; Membranes, Artificial; Phosphatidylserines; Piperidines; Thiazoles | 1990 |
Phosphatidylserine monolayers as models for drug uptake into membranes and tissue.
Topics: Animals; Aorta; Benzothiazoles; Cell Membrane; Diltiazem; Erythrocyte Membrane; Flunarizine; Heart Atria; Humans; Lidocaine; Membranes, Artificial; Models, Biological; Nitrendipine; Pharmaceutical Preparations; Pharmacokinetics; Phosphatidylserines; Piperidines; Rats; Thiazoles; Verapamil | 1990 |
Class IV Ca2+ antagonists do not affect lipid peroxidation in singlet oxygen challenged cardiomyocytes.
Topics: Animals; Benzothiazoles; Calcium Channel Blockers; Cell Separation; Cinnarizine; Diltiazem; Flunarizine; Lidoflazine; Lipid Peroxidation; Malondialdehyde; Myocardium; Nicardipine; Oxygen; Piperidines; Rats; Thiazoles; Verapamil | 1990 |
R 56865 differentiates between contractile agents with respect to the nifedipine-sensitive component in the isolated rat aorta.
Topics: Angiotensin II; Animals; Aorta, Thoracic; Arginine Vasopressin; Benzothiazoles; Calcium; Calcium Channels; Cytosol; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Piperidines; Rats; Rats, Inbred Strains; Serotonin; Thiazoles | 1989 |
The protective action of R56865 against ouabain-induced intoxication in rat heart isolated atria and ventricles.
Topics: Animals; Benzothiazoles; Biological Transport, Active; Electric Stimulation; Erythrocytes; Heart; In Vitro Techniques; Male; Myocardial Contraction; Ouabain; Piperidines; Rats; Rats, Inbred Strains; Sodium; Thiazoles | 1989 |
Different effects of R 56865 and calcium entry blockers on K+- and noradrenaline-induced contractions and 45Ca uptake in rat aorta.
Topics: Animals; Aorta; Benzothiazoles; Calcium; Calcium Channel Blockers; Diltiazem; Dose-Response Relationship, Drug; Flunarizine; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Norepinephrine; Piperidines; Potassium; Rats; Rats, Inbred Strains; Thiazoles; Verapamil | 1988 |
R 56865 prevents electrical and mechanical signs of ouabain intoxication in guinea-pig papillary muscle.
Topics: Animals; Arrhythmias, Cardiac; Benzothiazoles; Calcium; Electrophysiology; Guinea Pigs; Heart; In Vitro Techniques; Ouabain; Papillary Muscles; Piperidines; Thiazoles | 1987 |
Ion channel involvement in anoxic depolarization induced by cardiac arrest in rat brain.
Topics: Adenosine Triphosphate; Animals; Benzothiazoles; Calcium; Dizocilpine Maleate; Flunarizine; Glyburide; Heart Arrest; Hypoxia; Ion Channels; Male; Nimodipine; Piperidines; Potassium; Potassium Channels; Quinoxalines; Rats; Rats, Wistar; Sodium; Thiazoles | 1995 |
Alleviation of contractile dysfunction in ischemic hearts by slowly inactivating Na+ current blockers.
Topics: Action Potentials; Animals; Benzothiazoles; Biomechanical Phenomena; Electric Conductivity; Guinea Pigs; Heart; In Vitro Techniques; Male; Myocardial Contraction; Myocardial Ischemia; Myocardial Reperfusion; Papillary Muscles; Piperidines; Reference Values; Sodium; Tetrodotoxin; Thiazoles | 1995 |
Cardioprotective drugs decrease the Na+ background current.
Topics: Amiloride; Animals; Benzothiazoles; Guinea Pigs; Heart; Heart Arrest, Induced; Myocardium; Piperidines; Potassium; Sodium; Thiazoles; Verapamil | 1995 |
R 56 865, a Na+/Ca(2+)-overload inhibitor, protects against aconitine-induced cardiac arrhythmias in vivo.
Topics: Aconitine; Animals; Anti-Arrhythmia Agents; Benzothiazoles; Calcium; Dose-Response Relationship, Drug; Hemodynamics; Lidocaine; Male; Piperidines; Random Allocation; Rats; Rats, Wistar; Sodium; Sodium Channels; Tetrodotoxin; Thiazoles; Verapamil | 1993 |
Effect of R56865 on cardiac sarcoplasmic reticulum function and its role as an antagonist of digoxin at the sarcoplasmic reticulum calcium release channel.
Topics: Adenosine Triphosphate; Animals; Benzothiazoles; Calcium; Calcium Channel Blockers; Calcium Channels; Digoxin; Dose-Response Relationship, Drug; Heart; Patch-Clamp Techniques; Piperidines; Sarcoplasmic Reticulum; Sheep; Thiazoles | 1995 |
Attenuation by R 56865, a novel cytoprotective drug, of regional myocardial ischemia- and reperfusion-induced electrocardiographic disturbances in anesthetized rabbits.
Topics: Analysis of Variance; Animals; Arrhythmias, Cardiac; Benzothiazoles; Calcium Channel Blockers; Disease Models, Animal; Dose-Response Relationship, Drug; Electrocardiography; Heart; Hemodynamics; Injections, Intravenous; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Piperidines; Rabbits; Random Allocation; Thiazoles | 1995 |
Effects of R56865, an Na(+)- and Ca(2+)-overload inhibitor, on myocardial injury in ischemic, reperfused porcine hearts.
Topics: Animals; Benzothiazoles; Blood Pressure; Calcium; Calcium Channel Blockers; Coronary Circulation; Female; Heart Rate; Injections, Intravenous; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Oxygen Consumption; Piperidines; Sodium; Sodium Channel Blockers; Swine; Thiazoles; Ventricular Fibrillation | 1995 |
Effects of R 56865 on postischemic ventricular function in isolated rat working heart preparations obtained from healthy, diabetic and hypertensive animals.
Topics: Animals; Benzothiazoles; Blood Glucose; Blood Pressure; Body Weight; Calcium Channel Blockers; Cardiac Output; Coronary Circulation; Diabetes Mellitus, Experimental; Heart; Heart Ventricles; Hypertension; In Vitro Techniques; Male; Myocardial Ischemia; Piperidines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Wistar; Thiazoles; Ventricular Function; Ventricular Pressure | 1994 |
Effects of substrate-free anoxia and veratridine on intracellular calcium concentration in isolated rat ventricular cardiomyocytes.
Topics: Animals; Benzothiazoles; Calcium; Calcium Channel Blockers; Cell Hypoxia; Cell Separation; Cell Size; Male; Microscopy, Fluorescence; Myocardial Contraction; Myocardium; Piperidines; Rats; Rats, Wistar; Sodium; Thiazoles; Veratridine | 1994 |
Sodium channel blockade reduces hypoxic sodium loading and sodium-dependent calcium loading.
Topics: Amiloride; Animals; Benzofurans; Benzothiazoles; Calcium; Calcium Channel Blockers; Cell Separation; Ethers, Cyclic; Fluorescent Dyes; Hypoxia; Lidocaine; Myocardial Contraction; Myocardium; Piperidines; Rats; Sodium; Sodium Channel Blockers; Sodium-Hydrogen Exchangers; Tetrodotoxin; Thiazoles | 1994 |
Effects of R-56865 on transient inward current, Na(+)-Ca2+ exchange, and Ca2+ release from SR in cardiac myocytes.
Topics: Animals; Benzothiazoles; Calcium; Calcium Channel Blockers; Carrier Proteins; Cells, Cultured; Guinea Pigs; Heart; Kinetics; Membrane Potentials; Myocardium; Piperidines; Sarcoplasmic Reticulum; Sodium; Sodium-Calcium Exchanger; Thiazoles; Time Factors | 1994 |
R56865, a Na(+)- and Ca(2+)-overload inhibitor, reduces myocardial ischemia-reperfusion injury in blood-perfused rabbit hearts.
Topics: Animals; Benzothiazoles; Blood; Calcium; Energy Metabolism; Heart; Myocardial Reperfusion Injury; Myocardium; Perfusion; Piperidines; Rabbits; Sodium; Thiazoles; Ventricular Function, Left | 1993 |
R56865, an antiarrhythmic drug with class III effects that terminates ouabain induced ventricular tachycardia in an inverse rate dependent manner.
Topics: Animals; Anti-Arrhythmia Agents; Benzothiazoles; Dogs; Dose-Response Relationship, Drug; Female; Heart Rate; Hemodynamics; Male; Ouabain; Piperidines; Tachycardia; Thiazoles | 1993 |
R 56865 delays cellular electrical uncoupling in ischemic rabbit papillary muscle.
Topics: Action Potentials; Animals; Benzothiazoles; Calcium; Heart Conduction System; In Vitro Techniques; Myocardial Contraction; Myocardial Ischemia; Piperidines; Rabbits; Thiazoles | 1993 |
Interference of N-(1-[4-(4-fluorophenoxy)butyl]-piperidinyl)-N-methyl- 2-benzothiazolamine with Na+/H+ exchange and Na+/Ca2+ exchange in purified cardiac sarcolemmal membranes.
Topics: Amiloride; Animals; Benzothiazoles; Calcium; Cattle; Heart; Hydrogen; In Vitro Techniques; Ion Exchange; Membranes; Myocardial Reperfusion; Myocardium; Ouabain; Piperidines; Sarcolemma; Sodium; Thiazoles | 1993 |
R56865 inhibits catecholamine release from bovine chromaffin cells by blocking calcium channels.
Topics: Animals; Benzothiazoles; Calcium; Calcium Channel Blockers; Calcium Channels; Catecholamines; Cattle; Chromaffin System; Cytosol; Electroporation; Homeostasis; Piperidines; Potassium; Thiazoles | 1993 |
R56865 as Ca(2+)-channel blocker in Purkinje neurons of rat: comparison with flunarizine and nimodipine.
Topics: Animals; Benzothiazoles; Calcium Channel Blockers; Electrophysiology; Evoked Potentials; Flunarizine; In Vitro Techniques; Nimodipine; Piperidines; Purkinje Cells; Rats; Rats, Wistar; Thiazoles | 1993 |
R56865 and flunarizine as Na(+)-channel blockers in isolated Purkinje neurons of rat cerebellum.
Topics: Animals; Benzothiazoles; Calcium Channel Blockers; Cerebellum; Electric Stimulation; Electrophysiology; Flunarizine; In Vitro Techniques; Piperidines; Purkinje Cells; Rats; Rats, Wistar; Sodium Channels; Tetrodotoxin; Thiazoles | 1993 |
Inhibition of Na+/Ca2+ overload with R 56,865 protects against cardiac arrhythmias elicited by ouabain in vivo in guinea-pigs.
Topics: Animals; Arrhythmias, Cardiac; Benzothiazoles; Blood Pressure; Calcium; Electrocardiography; Guinea Pigs; Heart Rate; Lidocaine; Male; Ouabain; Piperidines; Sodium; Tetrodotoxin; Thiazoles; Verapamil | 1993 |
R56865 is antifibrillatory in reperfused ischemic guinea-pig hearts, even when given only during reperfusion.
Topics: Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Benzothiazoles; Calcium; Calcium Channel Blockers; Extracellular Space; Guinea Pigs; Heart; In Vitro Techniques; Lidocaine; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Piperidines; Potassium; Sodium; Thiazoles; Verapamil | 1995 |
Nature of the cardiomyocyte injury induced by lipid hydroperoxides.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Action Potentials; Amlodipine; Animals; Benzothiazoles; Calcium; Calcium Channel Blockers; Cells, Cultured; Dose-Response Relationship, Drug; Free Radical Scavengers; Free Radicals; Guinea Pigs; L-Lactate Dehydrogenase; Leukotrienes; Lipid Peroxides; Membrane Potentials; Myocardium; Necrosis; Piperidines; Rats; Rats, Wistar; Respiratory Burst; Ryanodine; Thiazoles; Vasoconstrictor Agents | 1995 |
In vivo effects of a novel calcium antagonist (R56865) against induced epoxyscillirosidin and tulp poisoning in sheep.
Topics: Animals; Benzothiazoles; Bufanolides; Calcium Channel Blockers; Cholenes; In Vitro Techniques; Piperidines; Plant Extracts; Plant Poisoning; Sheep; Sheep Diseases; Thiazoles; Toxins, Biological | 1995 |
The actions of ouabain and lithium chloride on cytosolic Ca2+ in single chromaffin cells.
Topics: Adrenal Glands; Animals; Antimanic Agents; Benzothiazoles; Calcium; Calcium Channel Blockers; Calcium Channels; Cattle; Cell Membrane; Cells, Cultured; Chromaffin System; Enzyme Inhibitors; Lithium Chloride; omega-Conotoxins; Ouabain; Peptides; Piperidines; Sodium; Sodium-Potassium-Exchanging ATPase; Thiazoles; Veratridine | 1996 |
The protective effects of CP-060S on ischaemia- and reperfusion- induced arrhythmias in anaesthetized rats.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzothiazoles; Calcium Channel Blockers; Diltiazem; Hemodynamics; Male; Myocardial Ischemia; Myocardial Reperfusion; Piperidines; Rats; Rats, Sprague-Dawley; Thiazoles; Thiazolidines | 1998 |
Late sodium current inhibition in human isolated cardiomyocytes by R 56865.
Topics: Benzothiazoles; Calcium Channel Blockers; Dose-Response Relationship, Drug; Heart Atria; Humans; Patch-Clamp Techniques; Piperidines; Sodium Channel Blockers; Sodium Channels; Thiazoles | 1998 |
Ischemia/reperfusion-induced arrhythmias in anaesthetized rats: a role of Na+ and Ca2+ influx.
Topics: Amiloride; Anesthesia; Animals; Arrhythmias, Cardiac; Benzothiazoles; Blood Pressure; Calcium; Calcium Channel Blockers; Calcium Channels; Heart Rate; Lidocaine; Male; Myocardial Reperfusion Injury; Piperidines; Rats; Rats, Wistar; Sodium; Sodium Channel Blockers; Sodium Channels; Thiazoles; Verapamil | 1999 |
The anti-ischemic effects of CP-060S during pacing-induced ischemia in anesthetized dogs.
Topics: Anesthesia; Animals; Benzothiazoles; Calcium Channel Blockers; Coronary Vessels; Diltiazem; Dogs; Drug Synergism; Electrocardiography; Ischemia; Male; Piperidines; Thiazoles; Thiazolidines | 1999 |
A Na+-activated K+ current (IK,Na) is present in guinea-pig but not rat ventricular myocytes.
Topics: Animals; Benzothiazoles; Calcium; Calcium Channel Blockers; Diltiazem; Electric Conductivity; Glyburide; Guinea Pigs; Heart; Magnesium; Male; Membrane Potentials; Patch-Clamp Techniques; Piperidines; Potassium; Potassium Channels; Rats; Rats, Sprague-Dawley; Sodium; Sodium-Potassium-Exchanging ATPase; Thiazoles; Ventricular Function | 1999 |
Electrophysiological actions of N-[1-[4-(4-fluorophenoxy)butyl]-4-piperidinyl]-N-methyl-2-benzothiazola mine (R56865) on CA1 neurons of the rat hippocampal slice during hypoxia.
Topics: Animals; Benzothiazoles; Calcium Channel Blockers; Electric Stimulation; Electrophysiology; Hippocampus; Hypoxia; In Vitro Techniques; Neurons; Piperidines; Rats; Reference Values; Synaptic Transmission; Thiazoles | 1999 |
Bepridil blunts the shortening of action potential duration caused by metabolic inhibition via blockade of ATP-sensitive K(+) channels and Na(+)-activated K(+) channels.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Benzothiazoles; Bepridil; Calcium Channel Blockers; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Dose-Response Relationship, Drug; Glyburide; Guinea Pigs; Heart Ventricles; In Vitro Techniques; Patch-Clamp Techniques; Perfusion; Piperidines; Potassium Channels; Sodium; Thiazoles; Time Factors; Uncoupling Agents | 1999 |
R 56865 exerts cardioprotective properties independent of the intracellular Na(+)-overload in the guinea pig heart.
Topics: Animals; Benzothiazoles; Cardiotonic Agents; Energy Metabolism; Guinea Pigs; Hydrogen-Ion Concentration; In Vitro Techniques; Intracellular Space; Magnetic Resonance Spectroscopy; Myocardial Contraction; Myocardium; Myocytes, Cardiac; Piperidines; Sodium; Thiazoles; Time Factors | 2003 |
Pharmacological characterisation of sodium channels in sinoatrial node pacemaking in the rat heart.
Topics: Animals; Benzothiazoles; Bradycardia; Heart Atria; Heart Rate; Lidocaine; Male; Piperidines; Rats; Rats, Sprague-Dawley; Sinoatrial Node; Sodium Channel Blockers; Sodium Channels; Tetrodotoxin; Thiadiazoles; Thiazoles | 2006 |
H(2)O(2)-induced left ventricular dysfunction in isolated working rat hearts is independent of calcium accumulation.
Topics: Animals; Anti-Arrhythmia Agents; Benzothiazoles; Calcium; Calcium Channel Blockers; Cardiotonic Agents; Cnidarian Venoms; Hydrogen Peroxide; Ion Transport; Lidocaine; Male; Myocardial Reperfusion Injury; Myocardium; Organ Culture Techniques; Ouabain; Oxidants; Piperidines; Rats; Rats, Sprague-Dawley; Ventricular Dysfunction, Left | 2008 |