pyrroles and vx-787
pyrroles has been researched along with vx-787 in 13 studies
Research
Studies (13)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 6 (46.15) | 24.3611 |
| 2020's | 7 (53.85) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Bandarage, UK; Bennani, Y; Bennett, H; Boyd, MJ; Byrn, RR; Charifson, PS; Clark, MP; Davies, I; Gu, W; Jacobs, M; Ledeboer, MW; Ledford, B; Leeman, JR; Perola, E; Wang, T | 1 |
| Barnard, DL; Jones, SM; Smee, DF | 1 |
| Cusack, S; Gaudon, S; Lethier, M; Pflug, A; Reich, S; Resa-Infante, P; Schulze, WM | 1 |
| Deleu, S; Hillewaert, V; Hoetelmans, RMW; Kakuda, TN; Leopold, L; Lwin, A; Spittaels, K; Vercauteren, JJ | 1 |
| Anderson, D; Finberg, RW; Fleischhackl, R; Kauffman, RS; Kosoglou, T; Lanno, R; Leopold, L; van Duijnhoven, W; Vingerhoets, J | 1 |
| Amblard, F; Amichai, S; Cox, B; Schinazi, R; Zandi, K; Zhang, H; Zhou, L | 1 |
| Martin-Loeches, I; O'Sullivan, S; Rodriguez, A; Torres, A | 1 |
| Takashita, E | 1 |
| Anderson, D; Deleu, S; Hallouin-Bernard, MC; Ison, MG; Kosoglou, T; Leopold, L; Nilsson, AC; O'Neil, B; Rossenu, S; Torres, A; Van Dromme, I; van Duijnhoven, W; Vingerhoets, J; Wilburn, JM | 1 |
| Chesnokov, A; Davis, TC; De La Cruz, JA; Gubareva, LV; Jones, J; Mishin, VP; Nguyen, HT; Patel, MC; Wentworth, DE; Zanders, N | 1 |
| Brynda, J; Fanfrlík, J; Gregor, J; Konvalinka, J; Kožíšek, M; Radilová, K | 1 |
| Bloom, JD; Eguia, RT; Malone, KD; Soh, YQS | 1 |
| Cao, R; Che, J; Li, X; Xu, L; Zhang, Q; Zhao, L | 1 |
Reviews
2 review(s) available for pyrroles and vx-787
| Article | Year |
|---|---|
Influenza management with new therapies.
Topics: Adrenal Cortex Hormones; Amides; Antiviral Agents; Critical Care; Critical Illness; Dibenzothiepins; Enzyme Inhibitors; Humans; Influenza, Human; Morpholines; Neuraminidase; Oseltamivir; Pyrazines; Pyridines; Pyridones; Pyrimidines; Pyrroles; Respiration, Artificial; Triazines; Zanamivir | 2020 |
Influenza Polymerase Inhibitors: Mechanisms of Action and Resistance.
Topics: Amides; Antiviral Agents; Dibenzothiepins; Drug Resistance, Viral; Humans; Influenza, Human; Morpholines; Orthomyxoviridae; Pyrazines; Pyridines; Pyridones; Pyrimidines; Pyrroles; RNA-Dependent RNA Polymerase; Triazines; Virus Replication | 2021 |
Trials
3 trial(s) available for pyrroles and vx-787
| Article | Year |
|---|---|
Single- and multiple-dose pharmacokinetics and safety of pimodivir, a novel, non-nucleoside polymerase basic protein 2 subunit inhibitor of the influenza A virus polymerase complex, and interaction with oseltamivir: a Phase 1 open-label study in healthy v
Topics: Adolescent; Adult; Antiviral Agents; Area Under Curve; Cross-Over Studies; Diarrhea; Double-Blind Method; Drug Interactions; Female; Humans; Male; Middle Aged; Oseltamivir; Pyridines; Pyrimidines; Pyrroles; Time Factors; Young Adult | 2018 |
Phase 2b Study of Pimodivir (JNJ-63623872) as Monotherapy or in Combination With Oseltamivir for Treatment of Acute Uncomplicated Seasonal Influenza A: TOPAZ Trial.
Topics: Acute Disease; Adult; Antiviral Agents; Diarrhea; Double-Blind Method; Drug Resistance, Viral; Drug Therapy, Combination; Early Termination of Clinical Trials; Female; Humans; Influenza A virus; Influenza, Human; Male; Middle Aged; Oseltamivir; Pyridines; Pyrimidines; Pyrroles; Time Factors; Viral Load; Viral Proteins; Virus Shedding | 2019 |
A Phase 2 Study of Pimodivir (JNJ-63623872) in Combination With Oseltamivir in Elderly and Nonelderly Adults Hospitalized With Influenza A Infection: OPAL Study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antiviral Agents; Humans; Influenza, Human; Middle Aged; Oseltamivir; Pyridines; Pyrroles; Treatment Outcome; Young Adult | 2022 |
Other Studies
8 other study(ies) available for pyrroles and vx-787
| Article | Year |
|---|---|
Isosteric replacements of the carboxylic acid of drug candidate VX-787: Effect of charge on antiviral potency and kinase activity of azaindole-based influenza PB2 inhibitors.
Topics: Antiviral Agents; Aza Compounds; Carboxylic Acids; Dose-Response Relationship, Drug; Indoles; Influenza A virus; Microbial Sensitivity Tests; Molecular Structure; Protein Kinase Inhibitors; Pyridines; Pyrimidines; Pyrroles; Structure-Activity Relationship; Viral Proteins | 2015 |
Activities of JNJ63623872 and oseltamivir against influenza A H1N1pdm and H3N2 virus infections in mice.
Topics: Animals; Antiviral Agents; Drug Discovery; Drug Therapy, Combination; Indoles; Influenza A Virus, H1N1 Subtype; Influenza A Virus, H3N2 Subtype; Lung; Mice; Orthomyxoviridae Infections; Oseltamivir; Pyridines; Pyrimidines; Pyrroles; Viral Load; Virus Replication | 2016 |
Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors.
Topics: Binding Sites; Crystallography, X-Ray; HEK293 Cells; Humans; Indoles; Influenza A virus; Protein Binding; Pyridines; Pyrimidines; Pyrroles; RNA; RNA Cap Analogs; RNA Caps; RNA Polymerase II; RNA, Messenger; Transcription, Genetic; Viral Proteins | 2018 |
Novel influenza polymerase PB2 inhibitors for the treatment of influenza A infection.
Topics: A549 Cells; Amino Acid Sequence; Animals; Antiviral Agents; Drug Discovery; Humans; Influenza A virus; Influenza, Human; Models, Molecular; Molecular Structure; Protein Binding; Pyridines; Pyrimidines; Pyrroles; RNA-Dependent RNA Polymerase; Structure-Activity Relationship; Viral Proteins; Virus Replication | 2019 |
Susceptibility of widely diverse influenza a viruses to PB2 polymerase inhibitor pimodivir.
Topics: Animals; Antiviral Agents; Drug Resistance, Viral; Enzyme Inhibitors; Humans; Influenza A virus; Influenza A Virus, H1N1 Subtype; Influenza A Virus, H3N2 Subtype; Influenza A Virus, H7N9 Subtype; Influenza, Human; Microbial Sensitivity Tests; Orthomyxoviridae Infections; Pyridines; Pyrimidines; Pyrroles; RNA-Dependent RNA Polymerase; Viral Proteins; Virus Replication | 2021 |
Structural and Thermodynamic Analysis of the Resistance Development to Pimodivir (VX-787), the Clinical Inhibitor of Cap Binding to PB2 Subunit of Influenza A Polymerase.
Topics: Crystallography, X-Ray; Drug Resistance, Viral; Influenza A virus; Models, Molecular; Mutant Proteins; Mutation; Protein Domains; Protein Subunits; Pyridines; Pyrimidines; Pyrroles; Quantum Theory; RNA-Dependent RNA Polymerase; Thermodynamics; Viral Proteins | 2021 |
Comprehensive Profiling of Mutations to Influenza Virus PB2 That Confer Resistance to the Cap-Binding Inhibitor Pimodivir.
Topics: A549 Cells; Animals; Antiviral Agents; Birds; Drug Resistance, Viral; Genetic Variation; Humans; Influenza A virus; Influenza in Birds; Mutation; Pyridines; Pyrimidines; Pyrroles; RNA Cap-Binding Proteins; Viral Proteins | 2021 |
Identification of novel influenza polymerase PB2 inhibitors using virtual screening approach and molecular dynamics simulation analysis of active compounds.
Topics: Antiviral Agents; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Influenza A Virus, H1N1 Subtype; Influenza A Virus, H3N2 Subtype; Microbial Sensitivity Tests; Molecular Dynamics Simulation; Molecular Structure; Pyridines; Pyrimidines; Pyrroles; Structure-Activity Relationship; Viral Proteins | 2021 |