Page last updated: 2024-08-18

pyrroles and vx-787

pyrroles has been researched along with vx-787 in 13 studies

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's6 (46.15)24.3611
2020's7 (53.85)2.80

Authors

AuthorsStudies
Bandarage, UK; Bennani, Y; Bennett, H; Boyd, MJ; Byrn, RR; Charifson, PS; Clark, MP; Davies, I; Gu, W; Jacobs, M; Ledeboer, MW; Ledford, B; Leeman, JR; Perola, E; Wang, T1
Barnard, DL; Jones, SM; Smee, DF1
Cusack, S; Gaudon, S; Lethier, M; Pflug, A; Reich, S; Resa-Infante, P; Schulze, WM1
Deleu, S; Hillewaert, V; Hoetelmans, RMW; Kakuda, TN; Leopold, L; Lwin, A; Spittaels, K; Vercauteren, JJ1
Anderson, D; Finberg, RW; Fleischhackl, R; Kauffman, RS; Kosoglou, T; Lanno, R; Leopold, L; van Duijnhoven, W; Vingerhoets, J1
Amblard, F; Amichai, S; Cox, B; Schinazi, R; Zandi, K; Zhang, H; Zhou, L1
Martin-Loeches, I; O'Sullivan, S; Rodriguez, A; Torres, A1
Takashita, E1
Anderson, D; Deleu, S; Hallouin-Bernard, MC; Ison, MG; Kosoglou, T; Leopold, L; Nilsson, AC; O'Neil, B; Rossenu, S; Torres, A; Van Dromme, I; van Duijnhoven, W; Vingerhoets, J; Wilburn, JM1
Chesnokov, A; Davis, TC; De La Cruz, JA; Gubareva, LV; Jones, J; Mishin, VP; Nguyen, HT; Patel, MC; Wentworth, DE; Zanders, N1
Brynda, J; Fanfrlík, J; Gregor, J; Konvalinka, J; Kožíšek, M; Radilová, K1
Bloom, JD; Eguia, RT; Malone, KD; Soh, YQS1
Cao, R; Che, J; Li, X; Xu, L; Zhang, Q; Zhao, L1

Reviews

2 review(s) available for pyrroles and vx-787

ArticleYear
Influenza management with new therapies.
    Current opinion in pulmonary medicine, 2020, Volume: 26, Issue:3

    Topics: Adrenal Cortex Hormones; Amides; Antiviral Agents; Critical Care; Critical Illness; Dibenzothiepins; Enzyme Inhibitors; Humans; Influenza, Human; Morpholines; Neuraminidase; Oseltamivir; Pyrazines; Pyridines; Pyridones; Pyrimidines; Pyrroles; Respiration, Artificial; Triazines; Zanamivir

2020
Influenza Polymerase Inhibitors: Mechanisms of Action and Resistance.
    Cold Spring Harbor perspectives in medicine, 2021, 05-03, Volume: 11, Issue:5

    Topics: Amides; Antiviral Agents; Dibenzothiepins; Drug Resistance, Viral; Humans; Influenza, Human; Morpholines; Orthomyxoviridae; Pyrazines; Pyridines; Pyridones; Pyrimidines; Pyrroles; RNA-Dependent RNA Polymerase; Triazines; Virus Replication

2021

Trials

3 trial(s) available for pyrroles and vx-787

ArticleYear
Single- and multiple-dose pharmacokinetics and safety of pimodivir, a novel, non-nucleoside polymerase basic protein 2 subunit inhibitor of the influenza A virus polymerase complex, and interaction with oseltamivir: a Phase 1 open-label study in healthy v
    British journal of clinical pharmacology, 2018, Volume: 84, Issue:11

    Topics: Adolescent; Adult; Antiviral Agents; Area Under Curve; Cross-Over Studies; Diarrhea; Double-Blind Method; Drug Interactions; Female; Humans; Male; Middle Aged; Oseltamivir; Pyridines; Pyrimidines; Pyrroles; Time Factors; Young Adult

2018
Phase 2b Study of Pimodivir (JNJ-63623872) as Monotherapy or in Combination With Oseltamivir for Treatment of Acute Uncomplicated Seasonal Influenza A: TOPAZ Trial.
    The Journal of infectious diseases, 2019, 03-15, Volume: 219, Issue:7

    Topics: Acute Disease; Adult; Antiviral Agents; Diarrhea; Double-Blind Method; Drug Resistance, Viral; Drug Therapy, Combination; Early Termination of Clinical Trials; Female; Humans; Influenza A virus; Influenza, Human; Male; Middle Aged; Oseltamivir; Pyridines; Pyrimidines; Pyrroles; Time Factors; Viral Load; Viral Proteins; Virus Shedding

2019
A Phase 2 Study of Pimodivir (JNJ-63623872) in Combination With Oseltamivir in Elderly and Nonelderly Adults Hospitalized With Influenza A Infection: OPAL Study.
    The Journal of infectious diseases, 2022, 08-12, Volume: 226, Issue:1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antiviral Agents; Humans; Influenza, Human; Middle Aged; Oseltamivir; Pyridines; Pyrroles; Treatment Outcome; Young Adult

2022

Other Studies

8 other study(ies) available for pyrroles and vx-787

ArticleYear
Isosteric replacements of the carboxylic acid of drug candidate VX-787: Effect of charge on antiviral potency and kinase activity of azaindole-based influenza PB2 inhibitors.
    Bioorganic & medicinal chemistry letters, 2015, May-01, Volume: 25, Issue:9

    Topics: Antiviral Agents; Aza Compounds; Carboxylic Acids; Dose-Response Relationship, Drug; Indoles; Influenza A virus; Microbial Sensitivity Tests; Molecular Structure; Protein Kinase Inhibitors; Pyridines; Pyrimidines; Pyrroles; Structure-Activity Relationship; Viral Proteins

2015
Activities of JNJ63623872 and oseltamivir against influenza A H1N1pdm and H3N2 virus infections in mice.
    Antiviral research, 2016, Volume: 136

    Topics: Animals; Antiviral Agents; Drug Discovery; Drug Therapy, Combination; Indoles; Influenza A Virus, H1N1 Subtype; Influenza A Virus, H3N2 Subtype; Lung; Mice; Orthomyxoviridae Infections; Oseltamivir; Pyridines; Pyrimidines; Pyrroles; Viral Load; Virus Replication

2016
Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors.
    Nucleic acids research, 2018, 01-25, Volume: 46, Issue:2

    Topics: Binding Sites; Crystallography, X-Ray; HEK293 Cells; Humans; Indoles; Influenza A virus; Protein Binding; Pyridines; Pyrimidines; Pyrroles; RNA; RNA Cap Analogs; RNA Caps; RNA Polymerase II; RNA, Messenger; Transcription, Genetic; Viral Proteins

2018
Novel influenza polymerase PB2 inhibitors for the treatment of influenza A infection.
    Bioorganic & medicinal chemistry letters, 2019, 10-15, Volume: 29, Issue:20

    Topics: A549 Cells; Amino Acid Sequence; Animals; Antiviral Agents; Drug Discovery; Humans; Influenza A virus; Influenza, Human; Models, Molecular; Molecular Structure; Protein Binding; Pyridines; Pyrimidines; Pyrroles; RNA-Dependent RNA Polymerase; Structure-Activity Relationship; Viral Proteins; Virus Replication

2019
Susceptibility of widely diverse influenza a viruses to PB2 polymerase inhibitor pimodivir.
    Antiviral research, 2021, Volume: 188

    Topics: Animals; Antiviral Agents; Drug Resistance, Viral; Enzyme Inhibitors; Humans; Influenza A virus; Influenza A Virus, H1N1 Subtype; Influenza A Virus, H3N2 Subtype; Influenza A Virus, H7N9 Subtype; Influenza, Human; Microbial Sensitivity Tests; Orthomyxoviridae Infections; Pyridines; Pyrimidines; Pyrroles; RNA-Dependent RNA Polymerase; Viral Proteins; Virus Replication

2021
Structural and Thermodynamic Analysis of the Resistance Development to Pimodivir (VX-787), the Clinical Inhibitor of Cap Binding to PB2 Subunit of Influenza A Polymerase.
    Molecules (Basel, Switzerland), 2021, Feb-14, Volume: 26, Issue:4

    Topics: Crystallography, X-Ray; Drug Resistance, Viral; Influenza A virus; Models, Molecular; Mutant Proteins; Mutation; Protein Domains; Protein Subunits; Pyridines; Pyrimidines; Pyrroles; Quantum Theory; RNA-Dependent RNA Polymerase; Thermodynamics; Viral Proteins

2021
Comprehensive Profiling of Mutations to Influenza Virus PB2 That Confer Resistance to the Cap-Binding Inhibitor Pimodivir.
    Viruses, 2021, 06-22, Volume: 13, Issue:7

    Topics: A549 Cells; Animals; Antiviral Agents; Birds; Drug Resistance, Viral; Genetic Variation; Humans; Influenza A virus; Influenza in Birds; Mutation; Pyridines; Pyrimidines; Pyrroles; RNA Cap-Binding Proteins; Viral Proteins

2021
Identification of novel influenza polymerase PB2 inhibitors using virtual screening approach and molecular dynamics simulation analysis of active compounds.
    Bioorganic & medicinal chemistry, 2021, 12-15, Volume: 52

    Topics: Antiviral Agents; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Influenza A Virus, H1N1 Subtype; Influenza A Virus, H3N2 Subtype; Microbial Sensitivity Tests; Molecular Dynamics Simulation; Molecular Structure; Pyridines; Pyrimidines; Pyrroles; Structure-Activity Relationship; Viral Proteins

2021