pyrroles has been researched along with urmc-099 in 16 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 13 (81.25) | 24.3611 |
| 2020's | 3 (18.75) | 2.80 |
| Authors | Studies |
|---|---|
| Barbieri, J; Dewhurst, S; Gantz Marker, MA; Gelbard, HA; Goodfellow, VS; Loweth, CJ; Lu, SM; Marker, DF; Muly, EC; Puccini, JM; Tremblay, MÈ | 1 |
| Dewhurst, S; Gelbard, HA; Goodfellow, VS; Loweth, CJ; Marker, DF; Nguyen, T; Polesskaya, O; Pollack, S; Ravula, SB; Sheppard, D; Todd, DE; Wiemann, T; Xu, Y | 1 |
| Chamberlain, JM; Daiss, JL; Dewhurst, S; Gelbard, HA; Goodfellow, V; Kim, M; Lebron, L; Polesskaya, O; Wong, C | 1 |
| Dewhurst, S; Feng, C; Gelbard, HA; Granger, M; Polesskaya, O; Rhoo, KH; Sur, J | 1 |
| Araínga, M; Ciborowski, P; Dash, PK; Gelbard, HA; Gendelman, HE; Goodfellow, VS; Gorantla, S; Guo, D; Haverland, NA; Knibbe-Hollinger, J; Liu, XM; Martinez-Skinner, A; McMillan, JM; Poluektova, LY; Wiederin, JL; Wysocki, BJ; Wysocki, TA; Zhang, G | 1 |
| Dong, W; Dyavarshetty, B; Embury, CM; Gelbard, HA; Gendelman, HE; Kiyota, T; Lu, Y; Whitmire, SM | 1 |
| Alnouti, Y; Bade, AN; Dash, PK; Edagwa, B; Gautam, N; Gelbard, HA; Gendelman, HE; Gnanadhas, DP; Gorantla, S; Lin, Z; McMillan, J; Mosley, RL; Palandri, DL; Sillman, B | 1 |
| Dyavarshetty, B; Gelbard, HA; Gendelman, HE; Kiyota, T; Lu, Y; Machhi, J; Mosley, RL; Nemati, M; Zhang, G | 1 |
| Dash, PK; Edagwa, B; Gelbard, H; Gendelman, HE; Gnanadhas, DP; Gorantla, S; Lin, Z; Machhi, J; McMillan, J; Thomas, MB | 1 |
| Aronovitz, MJ; Baumgartner, RA; Baur, WE; Blanton, RM; Calamaras, TD; Cooper, CW; Davis, RJ; Kapur, NK; Karas, RH; Li, N; McLaughlin, AL; Qiao, X; Richards, DA; Tam, K; Wang, GR | 1 |
| Gelbard, HA; Gendelman, HE; Gorantla, S; Kevadiya, BD; Marker, DF; Saminathan, P | 1 |
| Baht, GS; Gelbard, HA; Kong, C; Miller-Rhodes, P; Rodriguiz, RM; Saminathan, P; Terrando, N; Wetsel, WC | 1 |
| Bos, PH; Costa, J; Garcia-Diaz, A; Lowry, ER; Stockwell, BR; Thams, S; Wichterle, H; Zask, A | 1 |
| Danciu, O; Emmadi, R; Hoskins, K; Kumar, S; Nair, RS; Rana, A; Rana, B; Sethupathi, P; Singh, SK; Sinha, SC; Sondarva, G; Thatcher, GRJ; Viswakarma, N | 1 |
| Aguirre, JI; Aronovitz, MJ; Baca, P; Baumgartner, RA; Blanton, RM; Calamaras, TD; Davis, RJ; Jaffe, IZ; Karas, RH; Kim, SK; Lin, W; Liu, P; Martin, GL; McCarthy, JC; McLaughlin, AL; Pande, S; Richards, DA; Tam, K; Wang, GR | 1 |
| Chiang, W; Gelbard, HA; Li, H; Miller-Rhodes, P; Terrando, N; Velagapudi, R | 1 |
1 review(s) available for pyrroles and urmc-099
| Article | Year |
|---|---|
Broad Spectrum Mixed Lineage Kinase Type 3 Inhibition and HIV-1 Persistence in Macrophages.
Topics: AIDS Dementia Complex; Animals; HIV-1; Humans; Macrophages; MAP Kinase Kinase Kinases; Mitogen-Activated Protein Kinase Kinase Kinase 11; Protein Kinase Inhibitors; Pyridines; Pyrroles; Virus Latency | 2019 |
15 other study(ies) available for pyrroles and urmc-099
| Article | Year |
|---|---|
The new small-molecule mixed-lineage kinase 3 inhibitor URMC-099 is neuroprotective and anti-inflammatory in models of human immunodeficiency virus-associated neurocognitive disorders.
Topics: Animals; Bone Marrow Transplantation; Cell Line, Transformed; Cells, Cultured; CX3C Chemokine Receptor 1; Cytokines; Disease Models, Animal; Embryo, Mammalian; Gene Products, tat; Green Fluorescent Proteins; Hippocampus; HIV Infections; HIV-1; Humans; Inflammation; MAP Kinase Kinase Kinases; Mice; Mice, Transgenic; Microscopy, Immunoelectron; Mitogen-Activated Protein Kinase Kinase Kinase 11; Neuroprotective Agents; Phagocytosis; Phosphorylation; Pyridines; Pyrroles; Rats; Receptors, Chemokine; Signal Transduction; Statistics, Nonparametric; tat Gene Products, Human Immunodeficiency Virus; Time Factors; Transfection | 2013 |
Discovery, synthesis, and characterization of an orally bioavailable, brain penetrant inhibitor of mixed lineage kinase 3.
Topics: Administration, Oral; Animals; Area Under Curve; Biological Availability; Blood-Brain Barrier; Brain; Carbazoles; Cells, Cultured; Cognition Disorders; Drug Discovery; HIV Infections; Humans; JNK Mitogen-Activated Protein Kinases; Male; MAP Kinase Kinase Kinases; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase Kinase Kinase 11; Models, Chemical; Molecular Structure; Monocytes; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Pyrroles; tat Gene Products, Human Immunodeficiency Virus; Tumor Necrosis Factor-alpha | 2013 |
MLK3 regulates fMLP-stimulated neutrophil motility.
Topics: Animals; Cell Migration Inhibition; Cell Survival; Cells, Cultured; Chemotactic Factors; Immune System Diseases; Leukocyte Disorders; Male; MAP Kinase Kinase Kinases; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitogen-Activated Protein Kinase Kinase Kinase 11; N-Formylmethionine Leucyl-Phenylalanine; Neutrophil Activation; Protein Kinase Inhibitors; Pyridines; Pyrroles | 2014 |
Pharmacologic inhibition of MLK3 kinase activity blocks the in vitro migratory capacity of breast cancer cells but has no effect on breast cancer brain metastasis in a mouse xenograft model.
Topics: Animals; Brain Neoplasms; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Disease Models, Animal; Female; MAP Kinase Kinase Kinases; Mice; Mice, Nude; Mitogen-Activated Protein Kinase Kinase Kinase 11; Neoplasm Transplantation; Protein Kinase Inhibitors; Pyridines; Pyrroles; Transplantation, Heterologous | 2014 |
The mixed lineage kinase-3 inhibitor URMC-099 improves therapeutic outcomes for long-acting antiretroviral therapy.
Topics: Animals; Anti-Retroviral Agents; Antiretroviral Therapy, Highly Active; Atazanavir Sulfate; Drug Therapy, Combination; HIV Infections; HIV-1; Humans; MAP Kinase Kinase Kinases; Mice; Mice, SCID; Mitogen-Activated Protein Kinase Kinase Kinase 11; Nanocapsules; Protein Kinase Inhibitors; Pyridines; Pyrroles; Treatment Outcome | 2016 |
The mixed-lineage kinase 3 inhibitor URMC-099 facilitates microglial amyloid-β degradation.
Topics: Amyloid beta-Peptides; Animals; Animals, Newborn; Brain; Cells, Cultured; Cytokines; Enzyme-Linked Immunosorbent Assay; Lysosomal-Associated Membrane Protein 1; Mice; Microglia; Microscopy, Confocal; Mitogen-Activated Protein Kinase Kinases; Peptide Fragments; Protein Kinase Inhibitors; Pyridines; Pyrroles; rab GTP-Binding Proteins; rab7 GTP-Binding Proteins; Receptors, Scavenger; Signal Transduction; Statistics, Nonparametric | 2016 |
Autophagy facilitates macrophage depots of sustained-release nanoformulated antiretroviral drugs.
Topics: Acquired Immunodeficiency Syndrome; Animals; Anti-Retroviral Agents; Atazanavir Sulfate; Autophagy; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Female; Heterocyclic Compounds, 3-Ring; HIV-1; Humans; Macrophages; Male; Mice; Nanoparticles; Oxazines; Piperazines; Pyridines; Pyridones; Pyrroles | 2017 |
URMC-099 facilitates amyloid-β clearance in a murine model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Cells, Cultured; Disease Models, Animal; Hippocampus; Humans; Mice; Mice, Transgenic; Presenilin-1; Protein Kinase Inhibitors; Pyridines; Pyrroles | 2018 |
Modulating cellular autophagy for controlled antiretroviral drug release.
Topics: Anti-HIV Agents; Atazanavir Sulfate; Autophagy; beta-Cyclodextrins; Cell Survival; Clomipramine; Clonidine; Drug Carriers; Drug Interactions; Drug Liberation; HIV-1; Humans; Macrophages; Metformin; Nanoparticles; Particle Size; Pyridines; Pyrroles; Sirolimus; Tissue Distribution | 2018 |
Mixed lineage kinase-3 prevents cardiac dysfunction and structural remodeling with pressure overload.
Topics: Animals; Cardiac Output; Cardiomegaly; Cells, Cultured; Humans; Male; MAP Kinase Kinase 4; MAP Kinase Kinase Kinases; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase Kinase Kinase 11; Myocytes, Cardiac; Protein Kinase Inhibitors; Pyridines; Pyrroles; Rats; Rats, Sprague-Dawley; Ventricular Remodeling | 2019 |
The broad spectrum mixed-lineage kinase 3 inhibitor URMC-099 prevents acute microgliosis and cognitive decline in a mouse model of perioperative neurocognitive disorders.
Topics: Animals; Cognitive Dysfunction; Disease Models, Animal; Female; Male; MAP Kinase Kinase Kinases; Mice; Mice, Inbred C57BL; Microglia; Mitogen-Activated Protein Kinase Kinase Kinase 11; Neurocognitive Disorders; Perioperative Care; Pyridines; Pyrroles | 2019 |
Development of MAP4 Kinase Inhibitors as Motor Neuron-Protecting Agents.
Topics: Animals; Apoptosis; Binding Sites; Brain; Cell Differentiation; Cell Line; Endoplasmic Reticulum Stress; Half-Life; Humans; Induced Pluripotent Stem Cells; Intracellular Signaling Peptides and Proteins; JNK Mitogen-Activated Protein Kinases; Mice; Molecular Docking Simulation; Motor Neurons; Neuroprotective Agents; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyridines; Pyrroles; Signal Transduction | 2019 |
Mixed lineage kinase 3 inhibition induces T cell activation and cytotoxicity.
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Cyclophilin A; Female; Humans; Lymphocyte Activation; Lymphocytes, Tumor-Infiltrating; Mammary Neoplasms, Experimental; MAP Kinase Kinase Kinases; Mice; Mitogen-Activated Protein Kinase Kinase Kinase 11; NFATC Transcription Factors; Phosphorylation; Primary Cell Culture; Protein Kinase Inhibitors; Pyridines; Pyrroles; T-Lymphocytes, Cytotoxic; Tumor Escape | 2020 |
MLK3 mediates impact of PKG1α on cardiac function and controls blood pressure through separate mechanisms.
Topics: Animals; Aorta; Blood Pressure; Cyclic GMP-Dependent Protein Kinase Type I; Heart Failure; HEK293 Cells; Humans; Hypertension; Male; MAP Kinase Kinase Kinases; Mice; Mice, Knockout; Mitogen-Activated Protein Kinase Kinase Kinase 11; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phosphorylation; Protein Kinase Inhibitors; Pyrazoles; Pyridines; Pyrroles; Sildenafil Citrate; Vascular Stiffness; Vasodilator Agents; Ventricular Dysfunction, Left | 2021 |
URMC-099 prophylaxis prevents hippocampal vascular vulnerability and synaptic damage in an orthopedic model of delirium superimposed on dementia.
Topics: Animals; Delirium; Dementia; Hippocampus; Mice; Pyridines; Pyrroles | 2022 |